insulin-induced gene 1 protein isoform 1 [Homo sapiens]
INSIG family protein( domain architecture ID 10538083)
INSIG (insulin-induced gene) family protein similar to insulin-induced gene 1 protein and 1nsulin-induced gene 2 protein, which are oxysterol-binding proteins that mediate feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
INSIG | pfam07281 | Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced ... |
87-267 | 6.84e-61 | ||||
Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations. : Pssm-ID: 462131 Cd Length: 189 Bit Score: 190.91 E-value: 6.84e-61
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Name | Accession | Description | Interval | E-value | ||||
INSIG | pfam07281 | Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced ... |
87-267 | 6.84e-61 | ||||
Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations. Pssm-ID: 462131 Cd Length: 189 Bit Score: 190.91 E-value: 6.84e-61
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Name | Accession | Description | Interval | E-value | ||||
INSIG | pfam07281 | Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced ... |
87-267 | 6.84e-61 | ||||
Insulin-induced protein (INSIG); This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations. Pssm-ID: 462131 Cd Length: 189 Bit Score: 190.91 E-value: 6.84e-61
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Blast search parameters | ||||
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