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Conserved domains on  [gi|13027378|ref|NP_005462|]
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glucosamine-6-phosphate isomerase 1 [Homo sapiens]

Protein Classification

sugar phosphate isomerase family( domain architecture ID 368)

sugar phosphate isomerase family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SugarP_isomerase super family cl00339
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 1-253 1.61e-153

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


The actual alignment was detected with superfamily member PTZ00285:

Pssm-ID: 469729  Cd Length: 253  Bit Score: 428.79  E-value: 1.61e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378    1 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRD 80
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378   81 HPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVK 160
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  161 TLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCD 240
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|...
gi 13027378  241 EDATLELKVKTVK 253
Cdd:PTZ00285 241 EDATLELKVKTTK 253
 
Name Accession Description Interval E-value
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-253 1.61e-153

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 428.79  E-value: 1.61e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378    1 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRD 80
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378   81 HPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVK 160
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  161 TLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCD 240
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|...
gi 13027378  241 EDATLELKVKTVK 253
Cdd:PTZ00285 241 EDATLELKVKTTK 253
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-258 2.05e-143

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 403.42  E-value: 2.05e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378     1 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRD 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378    81 HPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378   161 TLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*...
gi 13027378   241 EDATLELKVKTVKYFKGL 258
Cdd:TIGR00502 241 ENATQELKVKTVEYFNEL 258
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 11-247 7.56e-140

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 393.39  E-value: 7.56e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  11 QASEWAAKYIRNRIIQFnpgpeKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMW 90
Cdd:cd01399   2 EMSEAAAELIAELIREK-----PPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  91 NNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILAN 170
Cdd:cd01399  77 ENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQAN 156

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13027378 171 ARFFDGElTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLEL 247
Cdd:cd01399 157 ARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-248 1.59e-115

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 332.51  E-value: 1.59e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378   1 MKLIILEHYSQ----ASEWAAKYIRNRIIQfnpgpEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVG 76
Cdd:COG0363   2 MRVIIFPDAEElaaaAAERAAERIAEAIAE-----KGRAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  77 LPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSR 156
Cdd:COG0363  77 LPPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSE 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378 157 T-RVKTLAMDTILANARFFDGeLTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRT 235
Cdd:COG0363 157 TdRVVTLDESTRQANARFFGS-IPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNV 235

                       250
                ....*....|...
gi 13027378 236 VFVCDEDATLELK 248
Cdd:COG0363 236 TWFLDEAAASLLT 248
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
16-223 1.65e-19

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 84.60  E-value: 1.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378    16 AAKYIRNRIIQF--NPGPekyFTLGLPTGSTPLGCYKKLIEYYknGDLSFKYVKTFNMDE-YVglPRDHPESYHSFMWNN 92
Cdd:pfam01182  10 LAERLAEALEAAlaERGR---FTLALSGGSTPKPLYELLAAAP--ARLDWSRVHVFWGDErCV--PPDDPDSNYGMAREA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378    93 FFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAA-GGIELFVG-----GIGPDGHIA--FnePGSSLVSRTRVKTLAM 164
Cdd:pfam01182  83 LLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELlPDLELPVFdlvllGMGPDGHTAslF--PGSPALEETDRLVVAV 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13027378   165 dtilanarfFDGELTKVPTMALTVGVgtVMDAREVMILITGAHKAFALYKAIEEGVNHM 223
Cdd:pfam01182 161 ---------TDSPKPPPERITLTLPV--LNAARRVWFLVTGAGKADALRRALAGDPDPL 208
 
Name Accession Description Interval E-value
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-253 1.61e-153

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 428.79  E-value: 1.61e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378    1 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRD 80
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378   81 HPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVK 160
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  161 TLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCD 240
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|...
gi 13027378  241 EDATLELKVKTVK 253
Cdd:PTZ00285 241 EDATLELKVKTTK 253
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-258 1.09e-152

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 426.94  E-value: 1.09e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378    1 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRD 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378   81 HPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  161 TLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250
                 ....*....|....*...
gi 13027378  241 EDATLELKVKTVKYFKGL 258
Cdd:PRK00443 241 EAAASELKVKTVKYFTEL 258
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-258 2.05e-143

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 403.42  E-value: 2.05e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378     1 MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRD 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378    81 HPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378   161 TLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*...
gi 13027378   241 EDATLELKVKTVKYFKGL 258
Cdd:TIGR00502 241 ENATQELKVKTVEYFNEL 258
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 11-247 7.56e-140

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 393.39  E-value: 7.56e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  11 QASEWAAKYIRNRIIQFnpgpeKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMW 90
Cdd:cd01399   2 EMSEAAAELIAELIREK-----PPAVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  91 NNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILAN 170
Cdd:cd01399  77 ENLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQAN 156

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13027378 171 ARFFDGElTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLEL 247
Cdd:cd01399 157 ARFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-248 1.59e-115

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 332.51  E-value: 1.59e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378   1 MKLIILEHYSQ----ASEWAAKYIRNRIIQfnpgpEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVG 76
Cdd:COG0363   2 MRVIIFPDAEElaaaAAERAAERIAEAIAE-----KGRAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  77 LPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSR 156
Cdd:COG0363  77 LPPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSE 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378 157 T-RVKTLAMDTILANARFFDGeLTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRT 235
Cdd:COG0363 157 TdRVVTLDESTRQANARFFGS-IPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNV 235

                       250
                ....*....|...
gi 13027378 236 VFVCDEDATLELK 248
Cdd:COG0363 236 TWFLDEAAASLLT 248
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 13-247 6.02e-72

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 233.38  E-value: 6.02e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378   13 SEWAAKYIRNRI---IQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFM 89
Cdd:PRK02122  36 SEEASRAVAQEIatlIRERQAEGKPCVLGLATGSSPIGVYAELIRMHREEGLSFKNVITFNLDEYYPMQPDSLQSYHRFM 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378   90 WNNFFKHIDIHPENTHILDG--NAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTI 167
Cdd:PRK02122 116 KENLFDHVDIPPENIHIPDGtiPKEEIDEYCRDYEEKIEAAGGIDFQLLGIGRTGHIGFNEPGSGRNSRTRLVTLDHITR 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  168 LANARFFDGElTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLEL 247
Cdd:PRK02122 196 RDAASDFFGE-ENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATFVLDLAAASEL 274
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 14-239 8.72e-38

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 131.32  E-value: 8.72e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  14 EWAAKYIRNRIIQFNPGPEKYFtLGLPTGSTPLGCYKKLIEYYKNGdlSFKYVKTFNMDEYVGLPrDHPESYHSFMWNNF 93
Cdd:cd00458   2 KEALKFIEDK*EKLLEEKDDMV-IGLGTGSTPAYFYKLLGEKLKRG--EISDIVGFPTDERYVPL-DSDQSNFRQAKLLA 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  94 FKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGpdghiafnepgsslvsrtrvktlamdtilanarf 173
Cdd:cd00458  78 FEHDIIPASNVHYVDTSLPIEKACEKYEREILDQVDAIDLAVDGAG---------------------------------- 123

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13027378 174 fdgeltkvptmaltvgvgtvMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVC 239
Cdd:cd00458 124 --------------------YRAGTVIVLVDGRKKVDYLCQNTEPGVIENGIFADIRGKEKDIVIV 169
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 1-236 6.33e-30

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 113.00  E-value: 6.33e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378    1 MKLIILEHYSQASEWAAKYIRNRIiqfnpGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRD 80
Cdd:PRK09762   1 QTLQQVENYTALSERASEYLLAVI-----RSKPDAVICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVKLDEWVDLPLT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378   81 HPESYHSFMWNNFFKHIDIHPENTHILDGNAVDlQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVK 160
Cdd:PRK09762  76 MPGTCETFLQQHIVQPLGLREDQLISFRSEEIN-ETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLQPACHIS 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13027378  161 TLAMDTILANARFFDGeltKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTV 236
Cdd:PRK09762 155 QLDARTQQHEMLKTAG---RPVTRGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHSNFI 227
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-247 1.03e-29

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 112.54  E-value: 1.03e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378    1 MKLIILEHYSQASEWAAKYIRNRIIQfnpgpEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLsFKYVKTFNMDEyvgLPRD 80
Cdd:PRK12358   1 MKIIITKDYEEMSRVAAHHLLGYMSK-----TKRVNLAITAGSTPKGMYEYLITLVKGKAW-YDNVHYYNFDE---IPFR 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378   81 HPESYH---SFMWNNFFKHIDIHPENTHILDgnaVDLQAEcdaFEEKIKAAGGIELFVGGIGPDGHIAFNEPG-SSLVSR 156
Cdd:PRK12358  72 GKEGEGvtiTNLRNLFFTPAGIKEENIHKLT---IDNYRE---HDQKLARDGGLDLVVLGLGADGHFCGNLPGtTHFHDE 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  157 TRVKTLA--MDTILANARFfDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPR 234
Cdd:PRK12358 146 TVEVPIQgeMVDIVAHGEL-GGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPN 224

                        250
                 ....*....|...
gi 13027378  235 TVFVCDEDATLEL 247
Cdd:PRK12358 225 LTVILDEAAAAEL 237
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
16-223 1.65e-19

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 84.60  E-value: 1.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378    16 AAKYIRNRIIQF--NPGPekyFTLGLPTGSTPLGCYKKLIEYYknGDLSFKYVKTFNMDE-YVglPRDHPESYHSFMWNN 92
Cdd:pfam01182  10 LAERLAEALEAAlaERGR---FTLALSGGSTPKPLYELLAAAP--ARLDWSRVHVFWGDErCV--PPDDPDSNYGMAREA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378    93 FFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAA-GGIELFVG-----GIGPDGHIA--FnePGSSLVSRTRVKTLAM 164
Cdd:pfam01182  83 LLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELlPDLELPVFdlvllGMGPDGHTAslF--PGSPALEETDRLVVAV 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13027378   165 dtilanarfFDGELTKVPTMALTVGVgtVMDAREVMILITGAHKAFALYKAIEEGVNHM 223
Cdd:pfam01182 161 ---------TDSPKPPPERITLTLPV--LNAARRVWFLVTGAGKADALRRALAGDPDPL 208
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 14-239 9.90e-18

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 79.91  E-value: 9.90e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  14 EWAAKYIRNRiiqfnpgpeKYFTLGLPTGSTPLGCYKKLIEYYKngdLSFKYVKTFNMDE-YVglPRDHPES-YHSFMwN 91
Cdd:cd01400  13 EALAAAIAKR---------GRFSLALSGGSTPKPLYELLAAAPA---LDWSKVHVFLGDErCV--PPDDPDSnYRLAR-E 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  92 NFFKHIDIHPENTHILDGNAvDLQAECDAFEEKIKAAGG----IELFVGGIGPDGHIA--FnePGSSLVSRTRVKtLAMD 165
Cdd:cd01400  78 ALLSHVAIPAANIHPIPTEL-GPEDAAAAYEKELRALFGgvppFDLVLLGMGPDGHTAslF--PGHPALLEETDR-LVVA 153

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13027378 166 TilanarfFDGELTKVPTMALTVGVgtVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVC 239
Cdd:cd01400 154 V-------TDSPKPPPERITLTLPV--LNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEVLWF 218
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 35-247 3.49e-14

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 70.10  E-value: 3.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378    35 FTLGLPTGSTPLGCYKKLIEyyknGDLSFKYVKTFNMDE-YVglPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVD 113
Cdd:TIGR01198  30 FSLALSGGRSPIALLEALAA----QPLDWSRIHLFLGDErYV--PLDHADSNTGLAREALLDRVAIPASNIHPMPTELSD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378   114 LQAECDAFEEKIKAA------GGIELFVGGIGPDGHIAFNEPGSSLV-SRTRVKTLAMDTIlanarffdgeltKVPTMAL 186
Cdd:TIGR01198 104 IEEAAELYEQELAAAfqpivfPVFDLLLLGMGPDGHTASLFPHTPALqETERLVTVLTKSP------------KPPHERI 171

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13027378   187 TVGVGTVMDAREVMILITGAHKAFALYKAIE-EGVNHMWTVSAFQQHPRTVFVCDEDATLEL 247
Cdd:TIGR01198 172 TLTLPAINAARKVFLLIAGEEKRNALAEALAvEAEPYPLPAAGVLHSGKTLWLLDYAAARKL 233
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 34-219 9.01e-04

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 40.23  E-value: 9.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378   34 YFTLGLPTGSTpLGCYKKLIE--YYKNGDLSFKYVktFNMDEYVgLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNA 111
Cdd:PLN02360  43 VFAIALSGGSL-ISFMGKLCEapYNKTVDWAKWYI--FWADERV-VAKNHADSNYKLAKDGLLSKVPVVPSHVYSINDTV 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027378  112 VDLQAECDaFE------EKIKAAG--------GIELFVGGIGPDGHIAFNEPG-SSLVSRTRVKTLAMDTilanarffdg 176
Cdd:PLN02360 119 TAEEAATD-YEfairqlVKTRTIGvsdisdcpKFDLILLGMGSDGHVASLFPNhPALEEKDDWVTFITDS---------- 187

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 13027378  177 elTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEG 219
Cdd:PLN02360 188 --PKPPPERITFTLPVINSASNVAVVATGESKANAVHLAIDDV 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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