melanoma-associated antigen 1 [Homo sapiens]
MAGE family protein( domain architecture ID 10575433)
MAGE family protein is a tumor-rejection antigen expressed on HLA-A1 of tumor cells and recognized by cytotoxic T-lymphocytes, similar to human Melanoma-associated antigen 3 (MAGE-A3) which may enhance ubiquitin(Ub) ligase activity of RING-type zinc finger-containing E3 Ub-protein ligases and TRIM28, and stimulate p53/TP53 ubiquitination by TRIM28
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
MAGE | pfam01454 | MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ... |
109-273 | 3.07e-19 | ||||
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis. : Pssm-ID: 426270 Cd Length: 205 Bit Score: 83.86 E-value: 3.07e-19
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MAGE_N | pfam12440 | Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and ... |
5-89 | 6.42e-17 | ||||
Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with pfam01454. This family is the N terminal of various melanoma associated antigens. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognized by cytotoxic T lymphocytes (CTLs). : Pssm-ID: 463582 [Multi-domain] Cd Length: 92 Bit Score: 74.26 E-value: 6.42e-17
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Name | Accession | Description | Interval | E-value | ||||
MAGE | pfam01454 | MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ... |
109-273 | 3.07e-19 | ||||
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis. Pssm-ID: 426270 Cd Length: 205 Bit Score: 83.86 E-value: 3.07e-19
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MAGE_N | pfam12440 | Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and ... |
5-89 | 6.42e-17 | ||||
Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with pfam01454. This family is the N terminal of various melanoma associated antigens. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognized by cytotoxic T lymphocytes (CTLs). Pssm-ID: 463582 [Multi-domain] Cd Length: 92 Bit Score: 74.26 E-value: 6.42e-17
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Name | Accession | Description | Interval | E-value | ||||
MAGE | pfam01454 | MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ... |
109-273 | 3.07e-19 | ||||
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis. Pssm-ID: 426270 Cd Length: 205 Bit Score: 83.86 E-value: 3.07e-19
|
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MAGE_N | pfam12440 | Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and ... |
5-89 | 6.42e-17 | ||||
Melanoma associated antigen family N terminal; This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with pfam01454. This family is the N terminal of various melanoma associated antigens. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognized by cytotoxic T lymphocytes (CTLs). Pssm-ID: 463582 [Multi-domain] Cd Length: 92 Bit Score: 74.26 E-value: 6.42e-17
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Blast search parameters | ||||
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