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Conserved domains on  [gi|17981694|ref|NP_004927|]
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cyclin-dependent kinase 4 inhibitor B isoform 1 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
18-138 2.15e-17

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 76.15  E-value: 2.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694  18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQV-MMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 96
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLaAANGNLEIVKLLLEAGADVNARDNDGET-PLHLAAENGHLEIV 202

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 17981694  97 VVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD 138
Cdd:COG0666 203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
18-138 2.15e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 76.15  E-value: 2.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694  18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQV-MMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 96
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLaAANGNLEIVKLLLEAGADVNARDNDGET-PLHLAAENGHLEIV 202

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 17981694  97 VVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD 138
Cdd:COG0666 203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244
Ank_2 pfam12796
Ankyrin repeats (3 copies);
21-110 1.72e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.88  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694    21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQV-MMMGSARVAELLLLHGAEPNCADPATltrPVHDAAREGFLDTLVVL 99
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLaAKNGHLEIVKLLLEHADVNLKDNGRT---ALHYAARSGHLEIVKLL 80

                          90
                  ....*....|.
gi 17981694   100 HRAGARLDVRD 110
Cdd:pfam12796  81 LEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 52-132 1.43e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694   52 QVMMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGY 131
Cdd:PTZ00322  88 QLAASGDAVGARILLTGGADPNCRDYDGRT-PLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                 .
gi 17981694  132 L 132
Cdd:PTZ00322 167 L 167
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
18-138 2.15e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 76.15  E-value: 2.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694  18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQV-MMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 96
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLaAANGNLEIVKLLLEAGADVNARDNDGET-PLHLAAENGHLEIV 202

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 17981694  97 VVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD 138
Cdd:COG0666 203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
18-132 1.17e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.57  E-value: 1.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694  18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRA-IQVMMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 96
Cdd:COG0666  58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLlHAAARNGDLEIVKLLLEAGADVNARDKDGET-PLHLAAYNGNLEIV 136

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 17981694  97 VVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
Cdd:COG0666 137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
21-110 1.72e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.88  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694    21 AAARGLVEKVRQLLEAGADPNGVNRFGRRAIQV-MMMGSARVAELLLLHGAEPNCADPATltrPVHDAAREGFLDTLVVL 99
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQDKNGRTALHLaAKNGHLEIVKLLLEHADVNLKDNGRT---ALHYAARSGHLEIVKLL 80

                          90
                  ....*....|.
gi 17981694   100 HRAGARLDVRD 110
Cdd:pfam12796  81 LEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
18-132 7.24e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.87  E-value: 7.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694  18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLV 97
Cdd:COG0666  25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104

                        90       100       110
                ....*....|....*....|....*....|....*
gi 17981694  98 VLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
Cdd:COG0666 105 LLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLL 139
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 52-132 1.43e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694   52 QVMMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGY 131
Cdd:PTZ00322  88 QLAASGDAVGARILLTGGADPNCRDYDGRT-PLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                 .
gi 17981694  132 L 132
Cdd:PTZ00322 167 L 167
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 28-120 2.11e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 45.64  E-value: 2.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694   28 EKVRQLLEAGADPNGVNR-FGRRAIQVMMMG-SARVAELLLLHGAEPNCADpATLTRPVHDAAREGFLDTLVVLHRAGAR 105
Cdd:PHA02878 148 EITKLLLSYGADINMKDRhKGNTALHYATENkDQRLTELLLSYGANVNIPD-KTNNSPLHHAVKHYNKPIVHILLENGAS 226

                         90
                 ....*....|....*
gi 17981694  106 LDVRDAWGRLPVDLA 120
Cdd:PHA02878 227 TDARDKCGNTPLHIS 241
PHA03095 PHA03095
ankyrin-like protein; Provisional
 28-134 6.74e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 44.25  E-value: 6.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694   28 EKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAEL---LLLHGAEPNCADpATLTRPVHDAAreGFLDTLVVLH--RA 102
Cdd:PHA03095 203 RIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLvlpLLIAGISINARN-RYGQTPLHYAA--VFNNPRACRRliAL 279

                         90       100       110
                 ....*....|....*....|....*....|...
gi 17981694  103 GARLDVRDAWGRLPVDLAEERGHRD-VAGYLRT 134
Cdd:PHA03095 280 GADINAVSSDGNTPLSLMVRNNNGRaVRAALAK 312
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
18-111 1.26e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.40  E-value: 1.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694  18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQV-MMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 96
Cdd:COG0666 190 LHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLaAENGNLEIVKLLLEAGADLNAKDKDGLT-ALLLAAAAGAALIV 268

                        90
                ....*....|....*
gi 17981694  97 VVLHRAGARLDVRDA 111
Cdd:COG0666 269 KLLLLALLLLAAALL 283
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 18-101 1.82e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694   18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVM-MMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 96
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIAcANGHVQVVRVLLEFGADPTLLDKDGKT-PLELAEENGFREVV 164


                 ....*
gi 17981694   97 VVLHR 101
Cdd:PTZ00322 165 QLLSR 169
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 20-123 5.51e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.59  E-value: 5.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694   20 SAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAEL--LLLHGAEPNCADPATLTrPVHDAAR-EGFLDTL 96
Cdd:PHA02876 280 ASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTENIrtLIMLGADVNAADRLYIT-PLHQASTlDRNKDIV 358

                         90       100
                 ....*....|....*....|....*..
gi 17981694   97 VVLHRAGARLDVRDAWGRLPVDLAEER 123
Cdd:PHA02876 359 ITLLELGANVNARDYCDKTPIHYAAVR 385
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 28-136 8.71e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.72  E-value: 8.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694   28 EKVRQLLEAGADPNGVNR----FGRRAIQvmmMGSARVAELLLLHGAEPNCADPATlTRPVHDAAREGFLDTLVVLHRAG 103
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAelktFLHYAIK---KGDLESIKMLFEYGADVNIEDDNG-CYPIHIAIKHNFFDIIKLLLEKG 180

                         90       100       110
                 ....*....|....*....|....*....|...
gi 17981694  104 ARLDVRDAWGRLPVDLAEERGHRDVAGYLRTAT 136
Cdd:PHA02874 181 AYANVKDNNGESPLHNAAEYGDYACIKLLIDHG 213
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 9-76 1.40e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 40.24  E-value: 1.40e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17981694    9 PSGGGsdEGLASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMM-GSARVAELLLLHGAEPNCAD 76
Cdd:PLN03192 619 PHAAG--DLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAeDHVDMVRLLIMNGADVDKAN 685
PHA03095 PHA03095
ankyrin-like protein; Provisional
 27-118 2.25e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 39.62  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694   27 VEKVRQLLEAGADPNGVNRFGRRAIQVMMMGS--ARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVV--LHRA 102
Cdd:PHA03095  63 KDIVRLLLEAGADVNAPERCGFTPLHLYLYNAttLDVIKLLIKAGADVNAKDKVGRT-PLHVYLSGFNINPKVIrlLLRK 141

                         90
                 ....*....|....*.
gi 17981694  103 GARLDVRDAWGRLPVD 118
Cdd:PHA03095 142 GADVNALDLYGMTPLA 157
PHA03095 PHA03095
ankyrin-like protein; Provisional
 27-132 5.47e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.47  E-value: 5.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17981694   27 VEKVRQLLEAGADPNGVNRFGRRAIQVMMMGS----ARVAELLLLHGAEPNCADPATLTrPVH----DAAREGFLDTLVv 98
Cdd:PHA03095  27 VEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSsekvKDIVRLLLEAGADVNAPERCGFT-PLHlylyNATTLDVIKLLI- 104

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 17981694   99 lhRAGARLDVRDAWGRLP--VDLAEERGHRDVAGYL 132
Cdd:PHA03095 105 --KAGADVNAKDKVGRTPlhVYLSGFNINPKVIRLL 138
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 51-113 7.86e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 38.31  E-value: 7.86e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17981694   51 IQVMMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLVVLHRAGARLDVRDAWG 113
Cdd:PLN03192 530 LTVASTGNAALLEELLKAKLDPDIGDSKGRT-PLHIAASKGYEDCVLVLLKHACNVHIRDANG 591
Ank_4 pfam13637
Ankyrin repeats (many copies);
18-66 2.34e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.17  E-value: 2.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 17981694    18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQ-VMMMGSARVAELLL 66
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDGNGETALHfAASNGNVEVLKLLL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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