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Conserved domains on  [gi|4759336|ref|NP_004620|]
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Fanconi anemia group G protein [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 207-295 4.86e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 4.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759336  207 LLTAFA---YRQGLQELITGNPDKALSSLHEAASGlcpRPVLVQVYTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPL 283
Cdd:COG2956   3 LPVAAAlgwYFKGLNYLLNGQPDKAIDLLEEALEL---DPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEAL 79

                        90
                ....*....|..
gi 4759336  284 LEASRLYQQLGD 295
Cdd:COG2956  80 LELAQDYLKAGL 91
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 207-295 4.86e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 4.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759336  207 LLTAFA---YRQGLQELITGNPDKALSSLHEAASGlcpRPVLVQVYTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPL 283
Cdd:COG2956   3 LPVAAAlgwYFKGLNYLLNGQPDKAIDLLEEALEL---DPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEAL 79

                        90
                ....*....|..
gi 4759336  284 LEASRLYQQLGD 295
Cdd:COG2956  80 LELAQDYLKAGL 91
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 207-295 4.86e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 4.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759336  207 LLTAFA---YRQGLQELITGNPDKALSSLHEAASGlcpRPVLVQVYTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPL 283
Cdd:COG2956   3 LPVAAAlgwYFKGLNYLLNGQPDKAIDLLEEALEL---DPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEAL 79

                        90
                ....*....|..
gi 4759336  284 LEASRLYQQLGD 295
Cdd:COG2956  80 LELAQDYLKAGL 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 222-296 5.98e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.48  E-value: 5.98e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4759336  222 TGNPDKALSSLHEAASGlcpRPVLVQVYTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPLLEASRLYQQLGDT 296
Cdd:COG4783  51 LGDLDEAIVLLHEALEL---DPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRP 122
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 211-296 7.66e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.56  E-value: 7.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759336  211 FAYRQGLQELITGNPDKALSSLHEAASGlcpRPVLVQVYTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPLLEASRLY 290
Cdd:COG2956 146 AYCELAELYLEQGDYDEAIEALEKALKL---DPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELY 222


                ....*.
gi 4759336  291 QQLGDT 296
Cdd:COG2956 223 EKLGDP 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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