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Conserved domains on  [gi|4759238|ref|NP_004607|]
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tetraspanin-8 [Homo sapiens]

Protein Classification

tetraspanin-8( domain architecture ID 13626496)

tetraspanin-8 is a transmembrane (TM) protein with four TM segments that acts as a molecular facilitator in diverse processes such as tissue differentiation, tumor-cell metastasis, and cell motility and cell fusion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TM4SF3_like_LEL cd03154
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. ...
 106-206 8.24e-44

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 3 (TM4SF3) or D6.1a and related proteins. D6.1a associates with alpha6beta4 integrin and supports cell motility, it has been ascribed a role in tumor progression and metastasis.


:

Pssm-ID: 239407 [Multi-domain]  Cd Length: 100  Bit Score: 142.95  E-value: 8.24e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759238  106 GAVFKSKSDRIVNETLYENTKLLSATGESEKQFQEAIIVFQEEFKCCGLVNGAADWGNNfqhYPELCACLDKQRPCQ--S 183
Cdd:cd03154   1 GIVGAVYKPKIENELKEKNTKLLSLLGQNAKSVKKSLEKFQKELKCCGLVNGADDWGND---IPASCNCTTTQSDCVvaY 77

                        90       100
                ....*....|....*....|...
gi 4759238  184 YNGKQVYKETCISFIKDFLAKNL 206
Cdd:cd03154  78 YGGSNVYKEPCISKIKDFLKKNL 100
Tetraspanin pfam00335
Tetraspanin family;
8-232 1.30e-27

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 103.94  E-value: 1.30e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759238      8 IKYSMFTFNFLFWLCGILILALAIWVRVSNDSQAIFGSEDVGSSSYvavdILIAVGAIIMILGFLGCCGAIKESRCMLLL 87
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPI----LLIVLGAVIFLVGFLGCCGALKENRCLLLT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759238     88 FFIGLLLILLLQVATGILGAVFKSKSDRIVNETLYEN-TKLLSATGESEKQFQEAIIVFQEEFKCCGlvngaadwgnnfq 166
Cdd:pfam00335  77 YFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSlEDGYRDWLDLYSCLNSALDSLQSEFGCCG------------- 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4759238    167 hypelcacldkqrpcqsyngkqvykeTCISFIKDFLAKNLIIVIGISFGLAVIEILGLVFSMVLYC 232
Cdd:pfam00335 144 --------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
TM4SF3_like_LEL cd03154
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. ...
 106-206 8.24e-44

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 3 (TM4SF3) or D6.1a and related proteins. D6.1a associates with alpha6beta4 integrin and supports cell motility, it has been ascribed a role in tumor progression and metastasis.


Pssm-ID: 239407 [Multi-domain]  Cd Length: 100  Bit Score: 142.95  E-value: 8.24e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759238  106 GAVFKSKSDRIVNETLYENTKLLSATGESEKQFQEAIIVFQEEFKCCGLVNGAADWGNNfqhYPELCACLDKQRPCQ--S 183
Cdd:cd03154   1 GIVGAVYKPKIENELKEKNTKLLSLLGQNAKSVKKSLEKFQKELKCCGLVNGADDWGND---IPASCNCTTTQSDCVvaY 77

                        90       100
                ....*....|....*....|...
gi 4759238  184 YNGKQVYKETCISFIKDFLAKNL 206
Cdd:cd03154  78 YGGSNVYKEPCISKIKDFLKKNL 100
Tetraspanin pfam00335
Tetraspanin family;
8-232 1.30e-27

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 103.94  E-value: 1.30e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759238      8 IKYSMFTFNFLFWLCGILILALAIWVRVSNDSQAIFGSEDVGSSSYvavdILIAVGAIIMILGFLGCCGAIKESRCMLLL 87
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPI----LLIVLGAVIFLVGFLGCCGALKENRCLLLT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759238     88 FFIGLLLILLLQVATGILGAVFKSKSDRIVNETLYEN-TKLLSATGESEKQFQEAIIVFQEEFKCCGlvngaadwgnnfq 166
Cdd:pfam00335  77 YFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSlEDGYRDWLDLYSCLNSALDSLQSEFGCCG------------- 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4759238    167 hypelcacldkqrpcqsyngkqvykeTCISFIKDFLAKNLIIVIGISFGLAVIEILGLVFSMVLYC 232
Cdd:pfam00335 144 --------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
 
Name Accession Description Interval E-value
TM4SF3_like_LEL cd03154
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. ...
 106-206 8.24e-44

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF3_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 3 (TM4SF3) or D6.1a and related proteins. D6.1a associates with alpha6beta4 integrin and supports cell motility, it has been ascribed a role in tumor progression and metastasis.


Pssm-ID: 239407 [Multi-domain]  Cd Length: 100  Bit Score: 142.95  E-value: 8.24e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759238  106 GAVFKSKSDRIVNETLYENTKLLSATGESEKQFQEAIIVFQEEFKCCGLVNGAADWGNNfqhYPELCACLDKQRPCQ--S 183
Cdd:cd03154   1 GIVGAVYKPKIENELKEKNTKLLSLLGQNAKSVKKSLEKFQKELKCCGLVNGADDWGND---IPASCNCTTTQSDCVvaY 77

                        90       100
                ....*....|....*....|...
gi 4759238  184 YNGKQVYKETCISFIKDFLAKNL 206
Cdd:cd03154  78 YGGSNVYKEPCISKIKDFLKKNL 100
Tetraspanin pfam00335
Tetraspanin family;
8-232 1.30e-27

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 103.94  E-value: 1.30e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759238      8 IKYSMFTFNFLFWLCGILILALAIWVRVSNDSQAIFGSEDVGSSSYvavdILIAVGAIIMILGFLGCCGAIKESRCMLLL 87
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPI----LLIVLGAVIFLVGFLGCCGALKENRCLLLT 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759238     88 FFIGLLLILLLQVATGILGAVFKSKSDRIVNETLYEN-TKLLSATGESEKQFQEAIIVFQEEFKCCGlvngaadwgnnfq 166
Cdd:pfam00335  77 YFVLLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSlEDGYRDWLDLYSCLNSALDSLQSEFGCCG------------- 143

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4759238    167 hypelcacldkqrpcqsyngkqvykeTCISFIKDFLAKNLIIVIGISFGLAVIEILGLVFSMVLYC 232
Cdd:pfam00335 144 --------------------------GCKEKLLEWLRKNLKIIGAGVIALGVIQLLGIILACCLCC 183
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 107-206 3.11e-14

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 65.99  E-value: 3.11e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759238  107 AVFKSKSDRIVNETLYENTKLLSATgeseKQFQEAIIVFQEEFKCCGlVNGAADWGNNFQHYPELCACLDKQRPCQSyng 186
Cdd:cd03127   1 FVYRDQLESLVSDTLNDAWDEYYVD----DDFQEAMDALQSTFECCG-VNGPTDYLDLRLLVPSSCCKGTDGNCGLN--- 72

                        90       100
                ....*....|....*....|
gi 4759238  187 kqVYKETCISFIKDFLAKNL 206
Cdd:cd03127  73 --LYTEGCLEKLVDFLRSNL 90
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 146-206 9.50e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 45.82  E-value: 9.50e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4759238  146 QEEFKCCGlVNGAADWgNNFQHY---PELCaCLDKQRPCQSYNGKQVYKETCISFIKDFLAKNL 206
Cdd:cd03165  38 QTEFRCCG-VTNYTDW-YEVLGEnrvPDSC-CQEDSQDCGRNPTELWWKTGCYEKVQQWLVDNL 98
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 145-206 1.95e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 42.33  E-value: 1.95e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4759238  145 FQEEFKCCGlVNGAADW---------GNNFQHYPELCaCLDKQRPCQSYNG--KQVYKET--CISFIKDFLAKNL 206
Cdd:cd03155  38 LQQEFKCCG-SNNYTDWqdsewinsnEANGRLVPDSC-CKTVVDRCGCLRDhpSNIYKVEggCIPKLEDFLYDHL 110
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 136-206 4.51e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 41.31  E-value: 4.51e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4759238  136 KQFQEAIIVFQEEFKCCGlVNGAADW----GNNFQHYPELCaCLDKQRPC-QSYNGKQVYKETCISFIKDFLAKNL 206
Cdd:cd03166  26 NDFRKILDRMQKDLKCCG-ANNYTDWenipSLDTDSVPDSC-CINVTKGCgINFDEKVIHLEGCVTKIEGWLKKNI 99
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 105-205 1.96e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 39.82  E-value: 1.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759238  105 LGAVFKSKSDRIVNETLYENTKLLSATGEsekQFQEAIIVFQEEFKCCGlVNGAADWGNN---FQH-------YPELC-- 172
Cdd:cd03156   1 LALFFKKDLEDSFKNLLKNNYGNYNSTGD---AITSTWNRVMIELKCCG-VNGPTDFVDStsfFRQknepnspYPESCck 76

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 4759238  173 ----ACLDKQRPCQSYNGKQVYKETCISFIKDFLAKN 205
Cdd:cd03156  77 rnsnSQIVDLDCPKLGSPNSYNKKGCYEKLSNPIERY 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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