|
Name |
Accession |
Description |
Interval |
E-value |
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
80-277 |
6.79e-142 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 418.23 E-value: 6.79e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 80 TLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFE 159
Cdd:cd17941 1 TLKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEDGLGALIISPTRELAMQIFE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 160 VLRKVGKNHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAV 239
Cdd:cd17941 81 VLRKVGKYHSFSAGLIIGGKDVKEEKERINRMNILVCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDMGFKETLDAI 160
|
170 180 190
....*....|....*....|....*....|....*...
gi 13514831 240 IENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVH 277
Cdd:cd17941 161 VENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISVH 198
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
68-470 |
3.50e-115 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 357.53 E-value: 3.50e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 68 ITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEalyRLQWTSTDGLGVLII 147
Cdd:COG0513 1 MMSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQ---RLDPSRPRAPQALIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 148 SPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMD-ETVSFHatDLQMLVLDEAD 225
Cdd:COG0513 78 APTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALkRGVDIVVATPGRLLDLIErGALDLS--GVETLVLDEAD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 226 RILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAkySTPATLEQNYIVCELQQKISVLY 305
Cdd:COG0513 156 RMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPEN--ATAETIEQRYYLVDKRDKLELLR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 306 SFLRSHLKKKSIVFFSSCKEVQYLYRVFCRLrpGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVN 385
Cdd:COG0513 234 RLLRDEDPERAIVFCNTKRGADRLAEKLQKR--GISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVS 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 386 WVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEKAMV---QQLLQKKVPVKEIK----INPEKLIDVQKKLESIL 458
Cdd:COG0513 312 HVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLraiEKLIGQKIEEEELPgfepVEEKRLERLKPKIKEKL 391
|
410
....*....|..
gi 13514831 459 AQDQDLKERAQR 470
Cdd:COG0513 392 KGKKAGRGGRPG 403
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
80-274 |
7.40e-81 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 258.83 E-value: 7.40e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 80 TLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFE 159
Cdd:cd17942 1 TLKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPRNGTGVIIISPTRELALQIYG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 160 VLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNA 238
Cdd:cd17942 81 VAKELLKYHSQTFGIVIGGANRKAEAEKLgKGVNILVATPGRLLDHLQNTKGFLYKNLQCLIIDEADRILEIGFEEEMRQ 160
|
170 180 190
....*....|....*....|....*....|....*..
gi 13514831 239 VIENLPKKRQTLLFSATQTKSVKDLARLSLKN-PEYV 274
Cdd:cd17942 161 IIKLLPKRRQTMLFSATQTRKVEDLARISLKKkPLYV 197
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
80-274 |
6.56e-79 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 253.52 E-value: 6.56e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 80 TLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRELAYQTFE 159
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKKKGRGPQALVLAPTRELAMQIAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 160 VLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMDETvSFHATDLQMLVLDEADRILDMGFADTMNA 238
Cdd:cd00268 81 VARKLGKGTGLKVAAIYGGAPIKKQIEALkKGPDIVVGTPGRLLDLIERG-KLDLSNVKYLVLDEADRMLDMGFEEDVEK 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 13514831 239 VIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 274
Cdd:cd00268 160 ILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
69-447 |
5.51e-75 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 252.41 E-value: 5.51e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 69 TRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEAL----YRLQwtstdglgV 144
Cdd:PRK11776 4 TAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLdvkrFRVQ--------A 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 145 LIISPTRELAYQTFEVLRKVGKnhdFSAGLII----GGK-------DLKHEAerinniNILVCTPGRLLQHMD-ETVSFh 212
Cdd:PRK11776 76 LVLCPTRELADQVAKEIRRLAR---FIPNIKVltlcGGVpmgpqidSLEHGA------HIIVGTPGRILDHLRkGTLDL- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 213 aTDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWV---HEKakystpATLE 289
Cdd:PRK11776 146 -DALNTLVLDEADRMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVestHDL------PAIE 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 290 QNYIVCELQQKISVLYSFLRSHLKKKSIVFFSSCKEVQYLYRVFCRLrpGVSILALHGRQQQMRRMEVYNEFVRKRAAVL 369
Cdd:PRK11776 219 QRFYEVSPDERLPALQRLLLHHQPESCVVFCNTKKECQEVADALNAQ--GFSALALHGDLEQRDRDQVLVRFANRSCSVL 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13514831 370 FATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEKAMVQQLLQkkvpVKEIKINPEKL 447
Cdd:PRK11776 297 VATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIED----YLGRKLNWEPL 370
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
81-271 |
7.72e-70 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 229.06 E-value: 7.72e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 81 LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEalyRLQWTSTDGLG--VLIISPTRELAYQTF 158
Cdd:cd17947 2 LRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILE---RLLYRPKKKAAtrVLVLVPTRELAMQCF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 159 EVLRKVGKNHDFSAGLIIGGKDLK-HEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMN 237
Cdd:cd17947 79 SVLQQLAQFTDITFALAVGGLSLKaQEAALRARPDIVIATPGRLIDHLRNSPSFDLDSIEILVLDEADRMLEEGFADELK 158
|
170 180 190
....*....|....*....|....*....|....
gi 13514831 238 AVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 271
Cdd:cd17947 159 EILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKP 192
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
69-408 |
1.99e-68 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 234.07 E-value: 1.99e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 69 TRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIIS 148
Cdd:PRK11192 1 TTFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRRKSGPPRILILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 149 PTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERIN-NINILVCTPGRLLQHMDETvSFHATDLQMLVLDEADRI 227
Cdd:PRK11192 81 PTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSeNQDIVVATPGRLLQYIKEE-NFDCRAVETLILDEADRM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 228 LDMGFADTMNAVIENLPKKRQTLLFSAT-QTKSVKDLARLSLKNPEYVWV----HEKAKystpatLEQNYIVCE-LQQKI 301
Cdd:PRK11192 160 LDMGFAQDIETIAAETRWRKQTLLFSATlEGDAVQDFAERLLNDPVEVEAepsrRERKK------IHQWYYRADdLEHKT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 302 SVLYSFLRSHLKKKSIVFFSSCKEVQYLyRVFCRLRpGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDF 381
Cdd:PRK11192 234 ALLCHLLKQPEVTRSIVFVRTRERVHEL-AGWLRKA-GINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDI 311
|
330 340
....*....|....*....|....*..
gi 13514831 382 PAVNWVLQFDCPEDANTYIHRAGRTAR 408
Cdd:PRK11192 312 DDVSHVINFDMPRSADTYLHRIGRTGR 338
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
93-274 |
7.94e-63 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 210.91 E-value: 7.94e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 93 TEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQ--WTSTDGLGVLIISPTRELAYQTFEVLRKVGKN-HD 169
Cdd:cd17949 15 TAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEprVDRSDGTLALVLVPTRELALQIYEVLEKLLKPfHW 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 170 FSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIE------- 241
Cdd:cd17949 95 IVPGYLIGGEKRKSEKARLrKGVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLDMGFEKDITKILEllddkrs 174
|
170 180 190
....*....|....*....|....*....|....*....
gi 13514831 242 ------NLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 274
Cdd:cd17949 175 kaggekSKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
80-274 |
9.87e-63 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 210.12 E-value: 9.87e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 80 TLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYR--LQWTSTDgLGVLIISPTRELAYQT 157
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKrkANLKKGQ-VGALIISPTRELATQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 158 FEVLRKVGKNHD--FSAGLIIGGKDLKHEAERI--NNINILVCTPGRL---LQHMDETVSFhaTDLQMLVLDEADRILDM 230
Cdd:cd17960 80 YEVLQSFLEHHLpkLKCQLLIGGTNVEEDVKKFkrNGPNILVGTPGRLeelLSRKADKVKV--KSLEVLVLDEADRLLDL 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 13514831 231 GFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 274
Cdd:cd17960 158 GFEADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRV 201
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
93-263 |
2.19e-61 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 205.17 E-value: 2.19e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 93 TEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQwtstDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSA 172
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLD----NGPQALVLAPTRELAEQIYEELKKLGKGLGLKV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 173 GLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHatDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLF 252
Cdd:pfam00270 77 ASLLGGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLK--NLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLL 154
|
170
....*....|.
gi 13514831 253 SATQTKSVKDL 263
Cdd:pfam00270 155 SATLPRNLEDL 165
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
71-440 |
2.28e-59 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 212.89 E-value: 2.28e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 71 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYR---LQWTSTDGLGVLII 147
Cdd:PRK04537 11 FSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSrpaLADRKPEDPRALIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 148 SPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLL----QHmdETVSFHATDLqmLVLD 222
Cdd:PRK04537 91 APTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQgVDVIIATPGRLIdyvkQH--KVVSLHACEI--CVLD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 223 EADRILDMGFADTMNAVIENLPKK--RQTLLFSATQTKSVKDLARLSLKNPEYVWVheKAKYSTPATLEQNYIVCELQQK 300
Cdd:PRK04537 167 EADRMFDLGFIKDIRFLLRRMPERgtRQTLLFSATLSHRVLELAYEHMNEPEKLVV--ETETITAARVRQRIYFPADEEK 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 301 ISVLYSFLRSHLKKKSIVFFSSCKEVQYLYRVFcrLRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLD 380
Cdd:PRK04537 245 QTLLLGLLSRSEGARTMVFVNTKAFVERVARTL--ERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLH 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13514831 381 FPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEAL-------LILLPSEKAMVQQllqkKVPVKEI 440
Cdd:PRK04537 323 IDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAIsfaceryAMSLPDIEAYIEQ----KIPVEPV 385
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
71-274 |
4.15e-59 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 200.22 E-value: 4.15e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 71 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEalyRLQWTSTD-GLGVLIISP 149
Cdd:cd17959 3 FQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIE---KLKAHSPTvGARALILSP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 150 TRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMDEtVSFHATDLQMLVLDEADRIL 228
Cdd:cd17959 80 TRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALaSNPDIIIATPGRLLHLLVE-MNLKLSSVEYVVFDEADRLF 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 13514831 229 DMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 274
Cdd:cd17959 159 EMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
71-271 |
5.50e-57 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 194.46 E-value: 5.50e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 71 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALyrlqWTSTDGLGVLIISPT 150
Cdd:cd17954 2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQAL----LENPQRFFALVLAPT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 151 RELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILD 229
Cdd:cd17954 78 RELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALaKKPHVIVATPGRLVDHLENTKGFSLKSLKFLVMDEADRLLN 157
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 13514831 230 MGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 271
Cdd:cd17954 158 MDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNP 199
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
69-440 |
2.64e-56 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 201.68 E-value: 2.64e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 69 TRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLG---VL 145
Cdd:PRK01297 87 TRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQLLQTPPPKERYMGeprAL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 146 IISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERI--NNINILVCTPGRLLQhMDETVSFHATDLQMLVLDE 223
Cdd:PRK01297 167 IIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLeaRFCDILVATPGRLLD-FNQRGEVHLDMVEVMVLDE 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 224 ADRILDMGFADTMNAVIENLPKK--RQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAKYStpATLEQNYIVCELQQKI 301
Cdd:PRK01297 246 ADRMLDMGFIPQVRQIIRQTPRKeeRQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVAS--DTVEQHVYAVAGSDKY 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 302 SVLYSFLRSHLKKKSIVFFSSCKEVQylyRVFCRL-RPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLD 380
Cdd:PRK01297 324 KLLYNLVTQNPWERVMVFANRKDEVR---RIEERLvKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIH 400
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13514831 381 FPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLIL-------LPSEKAMVQQLLQKKVPVKEI 440
Cdd:PRK01297 401 IDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAgeddafqLPEIEELLGRKISCEMPPAEL 467
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
76-274 |
1.53e-55 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 190.49 E-value: 1.53e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 76 LSKKTLKGLQEAQYRLVTEIQKQTIGLALQ-GKDVLGAAKTGSGKTLAFLVPVLEALYR-LQWTSTDGLGVLIISPTREL 153
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNtKPAGRRSGVSALIISPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 154 AYQTFEVLRKV-GKNHDFSAGLIIGGKDLKHEAERI--NNINILVCTPGRLLQHMDETVSFHA-TDLQMLVLDEADRILD 229
Cdd:cd17964 81 ALQIAAEAKKLlQGLRKLRVQSAVGGTSRRAELNRLrrGRPDILVATPGRLIDHLENPGVAKAfTDLDYLVLDEADRLLD 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 13514831 230 MGFADTMNAVIENLPKK----RQTLLFSATQTKSVKDLARLSL-KNPEYV 274
Cdd:cd17964 161 MGFRPDLEQILRHLPEKnadpRQTLLFSATVPDEVQQIARLTLkKDYKFI 210
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
67-445 |
6.40e-54 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 196.53 E-value: 6.40e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 67 EITRFSDFplskkTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPV---LEALYRLQWTstDGLG 143
Cdd:PTZ00110 133 EYTSFPDY-----ILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAivhINAQPLLRYG--DGPI 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 144 VLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGG--KDLKHEAERiNNINILVCTPGRLLQHMDETVsfhaTDLQ---M 218
Cdd:PTZ00110 206 VLVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGvpKRGQIYALR-RGVEILIACPGRLIDFLESNV----TNLRrvtY 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 219 LVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARlSLKNPEYVWVHEKA-KYSTPATLEQNYIVCEL 297
Cdd:PTZ00110 281 LVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLAR-DLCKEEPVHVNVGSlDLTACHNIKQEVFVVEE 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 298 QQKISVLYSFLRSHLKK--KSIVFFSSCKEVQYLYRVFcRLRpGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIA 375
Cdd:PTZ00110 360 HEKRGKLKMLLQRIMRDgdKILIFVETKKGADFLTKEL-RLD-GWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVA 437
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13514831 376 ARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEKAMVQQLLQ------KKVPVKEIKINPE 445
Cdd:PTZ00110 438 SRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTPDKYRLARDLVKvlreakQPVPPELEKLSNE 513
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
71-276 |
3.39e-53 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 183.96 E-value: 3.39e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 71 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALyrlqwtSTDGLGV--LIIS 148
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL------SEDPYGIfaLVLT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 149 PTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNI-NILVCTPGRLLQHM----DETVSFHatDLQMLVLDE 223
Cdd:cd17955 75 PTRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRpHIVVATPGRLADHLrssdDTTKVLS--RVKFLVLDE 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 13514831 224 ADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPeYVWV 276
Cdd:cd17955 153 ADRLLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKP-FFWE 204
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
69-449 |
7.94e-53 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 190.18 E-value: 7.94e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 69 TRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALyrLQWTSTDGLGV---- 144
Cdd:PRK04837 8 QKFSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYL--LSHPAPEDRKVnqpr 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 145 -LIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQHMDETVsFHATDLQMLVLD 222
Cdd:PRK04837 86 aLIMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESgVDILIGTTGRLIDYAKQNH-INLGAIQVVVLD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 223 EADRILDMGFADTMNAVIENLP--KKRQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAKYSTPATLEQNYIVCElqQK 300
Cdd:PRK04837 165 EADRMFDLGFIKDIRWLFRRMPpaNQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELFYPSNE--EK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 301 ISVLYSFLRSHLKKKSIVFFS---SCKEV-QYL----YRVfcrlrpGVsilaLHGRQQQMRRMEVYNEFVRKRAAVLFAT 372
Cdd:PRK04837 243 MRLLQTLIEEEWPDRAIIFANtkhRCEEIwGHLaadgHRV------GL----LTGDVAQKKRLRILEEFTRGDLDILVAT 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 373 DIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDG-------EALLILLPSekamVQQLLQKKVPVKeiKINPE 445
Cdd:PRK04837 313 DVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGhsislacEEYALNLPA----IETYIGHSIPVS--KYDSD 386
|
....
gi 13514831 446 KLID 449
Cdd:PRK04837 387 ALLT 390
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
71-436 |
6.51e-52 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 188.48 E-value: 6.51e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 71 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGV--LIIS 148
Cdd:PRK10590 3 FDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRRPVraLILT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 149 PTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLL--QHMDetvsfhATDL---QMLVLD 222
Cdd:PRK10590 83 PTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLrGGVDVLVATPGRLLdlEHQN------AVKLdqvEILVLD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 223 EADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVwvhEKAKYSTPA-TLEQNYIVCELQQKI 301
Cdd:PRK10590 157 EADRMLDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEI---EVARRNTASeQVTQHVHFVDKKRKR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 302 SVLYSFLRSHLKKKSIVFFSSCKEVQYLYRVFCrlRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDF 381
Cdd:PRK10590 234 ELLSQMIGKGNWQQVLVFTRTKHGANHLAEQLN--KDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDI 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 13514831 382 PAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEKAM---VQQLLQKKVP 436
Cdd:PRK10590 312 EELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDEHKLlrdIEKLLKKEIP 369
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
68-432 |
2.13e-49 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 183.07 E-value: 2.13e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 68 ITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLE--ALYRLQWTSTD-GLGV 144
Cdd:PLN00206 120 ILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISrcCTIRSGHPSEQrNPLA 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 145 LIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLqhmdETVSFHATDLQ---MLV 220
Cdd:PLN00206 200 MVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQgVELIVGTPGRLI----DLLSKHDIELDnvsVLV 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 221 LDEADRILDMGFADTMNAVIENLPKKrQTLLFSATQTKSVKDLARLSLKNPEYVWVHEKAKYStpATLEQNYIVCELQQK 300
Cdd:PLN00206 276 LDEVDCMLERGFRDQVMQIFQALSQP-QVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPN--KAVKQLAIWVETKQK 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 301 ISVLYSFLRS--HLKKKSIVFFSSCKEVQYLYRVFcRLRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARG 378
Cdd:PLN00206 353 KQKLFDILKSkqHFKPPAVVFVSSRLGADLLANAI-TVVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRG 431
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 13514831 379 LDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEKAMVQQLLQ 432
Cdd:PLN00206 432 VDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNLFPELVA 485
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
69-462 |
2.69e-48 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 181.97 E-value: 2.69e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 69 TRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYrlqwTSTDGLGVLIIS 148
Cdd:PRK11634 6 TTFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLD----PELKAPQILVLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 149 PTRELAYQTFEVLRKVGKN-HDFSAGLIIGGK--DLKHEAERiNNINILVCTPGRLLQHMDETvSFHATDLQMLVLDEAD 225
Cdd:PRK11634 82 PTRELAVQVAEAMTDFSKHmRGVNVVALYGGQryDVQLRALR-QGPQIVVGTPGRLLDHLKRG-TLDLSKLSGLVLDEAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 226 RILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVheKAKYSTPATLEQNYIVCELQQKISVLY 305
Cdd:PRK11634 160 EMLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRI--QSSVTTRPDISQSYWTVWGMRKNEALV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 306 SFLRSHLKKKSIVFF---SSCKEVQYLYRvfcrlRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFP 382
Cdd:PRK11634 238 RFLEAEDFDAAIIFVrtkNATLEVAEALE-----RNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVE 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 383 AVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEKAMVQQLLQK-KVPVKEIKINPEKLIDvQKKLESILAQD 461
Cdd:PRK11634 313 RISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERRLLRNIERTmKLTIPEVELPNAELLG-KRRLEKFAAKV 391
|
.
gi 13514831 462 Q 462
Cdd:PRK11634 392 Q 392
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
71-276 |
7.11e-48 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 169.59 E-value: 7.11e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 71 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLG------V 144
Cdd:cd17967 2 FEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSVGRGRrkaypsA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 145 LIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMD-ETVSFhaTDLQMLVLD 222
Cdd:cd17967 82 LILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLlRGCDILVATPGRLVDFIErGRISL--SSIKFLVLD 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 13514831 223 EADRILDMGFADTMNAVIE--NLPKK--RQTLLFSATQTKSVKDLARLSLKNpeYVWV 276
Cdd:cd17967 160 EADRMLDMGFEPQIRKIVEhpDMPPKgeRQTLMFSATFPREIQRLAADFLKN--YIFL 215
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
71-271 |
1.90e-47 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 167.47 E-value: 1.90e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 71 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYrlqwTSTDGLGVLIISPT 150
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKID----PKKDVIQALILVPT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 151 RELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQHMDETVSfHATDLQMLVLDEADRILD 229
Cdd:cd17940 77 RELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQtVHVLVGTPGRILDLAKKGVA-DLSHCKTLVLDEADKLLS 155
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 13514831 230 MGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 271
Cdd:cd17940 156 QDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNP 197
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
81-271 |
1.23e-46 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 165.07 E-value: 1.23e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 81 LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQwtSTDGLGVLIISPTRELAYQTFEV 160
Cdd:cd17957 2 LNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPR--KKKGLRALILAPTRELASQIYRE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 161 LRKVGKNHDFSAGLIIGG--KDLKHEAERINNINILVCTPGRLLQHMDETvsfhATDL---QMLVLDEADRILDMGFADT 235
Cdd:cd17957 80 LLKLSKGTGLRIVLLSKSleAKAKDGPKSITKYDILVSTPLRLVFLLKQG----PIDLssvEYLVLDEADKLFEPGFREQ 155
|
170 180 190
....*....|....*....|....*....|....*..
gi 13514831 236 MNAVIENLP-KKRQTLLFSATQTKSVKDLARLSLKNP 271
Cdd:cd17957 156 TDEILAACTnPNLQRSLFSATIPSEVEELARSVMKDP 192
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
288-419 |
2.68e-46 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 161.52 E-value: 2.68e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 288 LEQNYIVCELQQKISVLY-SFLRSHLKKKSIVFFSSCKEVQYLYRVFCRLrpGVSILALHGRQQQMRRMEVYNEFVRKRA 366
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLlLLLEKLKPGKAIIFVNTKKRVDRLAELLEEL--GIKVAALHGDLSQEERERALKKFRSGKV 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 13514831 367 AVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLIL 419
Cdd:cd18787 79 RVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
81-274 |
3.62e-45 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 161.72 E-value: 3.62e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 81 LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRL----QWTSTDGLGVLIISPTRELAYQ 156
Cdd:cd17945 2 LRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLppldEETKDDGPYALILAPTRELAQQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 157 TFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQHMDEtvsfHATDL---QMLVLDEADRILDMGF 232
Cdd:cd17945 82 IEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNgCEILIATPGRLLDCLER----RLLVLnqcTYVVLDEADRMIDMGF 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13514831 233 ADTMNAVIENLP--------------------KKRQTLLFSATQTKSVKDLARLSLKNPEYV 274
Cdd:cd17945 158 EPQVTKILDAMPvsnkkpdteeaeklaasgkhRYRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
93-274 |
3.06e-44 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 158.42 E-value: 3.06e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 93 TEIQKQTIGLALQG-KDVLGAAKTGSGKTLAFLVPVLEALYRlqwtsTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFS 171
Cdd:smart00487 10 RPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALKR-----GKGGRVLVLVPTRELAEQWAEELKKLGPSLGLK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 172 AGLIIGGKDLKHEAERINN--INILVCTPGRLLQHMDETvSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQT 249
Cdd:smart00487 85 VVGLYGGDSKREQLRKLESgkTDILVTTPGRLLDLLEND-KLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPKNVQL 163
|
170 180
....*....|....*....|....*
gi 13514831 250 LLFSATQTKSVKDLARLSLKNPEYV 274
Cdd:smart00487 164 LLLSATPPEEIENLLELFLNDPVFI 188
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
44-276 |
2.01e-42 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 155.51 E-value: 2.01e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 44 PEwqvERESISRLMQ------NYEKINVN--------EITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDV 109
Cdd:cd18052 7 PE---DEDEIFATIQtginfdKYDEIPVEvtgrnpppAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 110 LGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGV-----LIISPTRELAYQTFEVLRKvgknhdFSAGLII------GG 178
Cdd:cd18052 84 MACAQTGSGKTAAFLLPVLTGMMKEGLTASSFSEVqepqaLIVAPTRELANQIFLEARK------FSYGTCIrpvvvyGG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 179 KDLKHEAERI-NNINILVCTPGRLLQHMD-ETVSFhaTDLQMLVLDEADRILDMGFADTMNAVIE--NLPKK--RQTLLF 252
Cdd:cd18052 158 VSVGHQIRQIeKGCHILVATPGRLLDFIGrGKISL--SKLKYLILDEADRMLDMGFGPEIRKLVSepGMPSKedRQTLMF 235
|
250 260
....*....|....*....|....
gi 13514831 253 SATQTKSVKDLARlSLKNPEYVWV 276
Cdd:cd18052 236 SATFPEEIQRLAA-EFLKEDYLFL 258
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
68-271 |
9.98e-41 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 149.45 E-value: 9.98e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 68 ITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALyRLQWTSTDGLG--VL 145
Cdd:cd17953 11 IQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHI-KDQRPVKPGEGpiGL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 146 IISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHE-AERINNINILVCTPGRLLQhMDETVSFHATDLQ---MLVL 221
Cdd:cd17953 90 IMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQiAELKRGAEIVVCTPGRMID-ILTANNGRVTNLRrvtYVVL 168
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 13514831 222 DEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 271
Cdd:cd17953 169 DEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKP 218
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
81-271 |
5.55e-40 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 146.72 E-value: 5.55e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 81 LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPV----LEALYRLQWTSTDGLGVLIISPTRELAYQ 156
Cdd:cd17951 2 LKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLimfaLEQEKKLPFIKGEGPYGLIVCPSRELARQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 157 TFEVLRKVGKNhdFSAG--------LIIGGKDLKHEAERINN-INILVCTPGRLlQHMDETVSFHATDLQMLVLDEADRI 227
Cdd:cd17951 82 THEVIEYYCKA--LQEGgypqlrclLCIGGMSVKEQLEVIRKgVHIVVATPGRL-MDMLNKKKINLDICRYLCLDEADRM 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 13514831 228 LDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 271
Cdd:cd17951 159 IDMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKP 202
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
76-271 |
6.23e-40 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 146.57 E-value: 6.23e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 76 LSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTS--TDGLGVLIISPTREL 153
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESgeEQGTRALILVPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 154 AYQTFEVLRKVGK---NHDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDM 230
Cdd:cd17961 81 AQQVSKVLEQLTAycrKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLVLSY 160
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 13514831 231 GFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 271
Cdd:cd17961 161 GYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNP 201
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
81-271 |
5.88e-39 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 143.28 E-value: 5.88e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 81 LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVL---EALYRLQwtSTDGLGVLIISPTRELAYQT 157
Cdd:cd17966 2 MDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIvhiNAQPPLE--RGDGPIVLVLAPTRELAQQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 158 FEVLRKVGKNHDFSAGLIIGG-------KDLKHEAErinninILVCTPGRLLQHMDETvsfhATDLQ---MLVLDEADRI 227
Cdd:cd17966 80 QQEANKFGGSSRLRNTCVYGGapkgpqiRDLRRGVE------ICIATPGRLIDFLDQG----KTNLRrvtYLVLDEADRM 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 13514831 228 LDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 271
Cdd:cd17966 150 LDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDY 193
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
81-271 |
2.61e-38 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 141.40 E-value: 2.61e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 81 LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVL-EALYRLQWTSTDGLGVLIISPTRELAYQTFE 159
Cdd:cd17952 2 LNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLvHIMDQRELEKGEGPIAVIVAPTRELAQQIYL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 160 VLRKVGKNHDFSAGLIIGG-------KDLKHEAErinninILVCTPGRLLQHmdetVSFHATDLQ---MLVLDEADRILD 229
Cdd:cd17952 82 EAKKFGKAYNLRVVAVYGGgskweqaKALQEGAE------IVVATPGRLIDM----VKKKATNLQrvtYLVLDEADRMFD 151
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 13514831 230 MGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 271
Cdd:cd17952 152 MGFEYQVRSIVGHVRPDRQTLLFSATFKKKIEQLARDILSDP 193
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
80-274 |
3.54e-38 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 140.86 E-value: 3.54e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 80 TLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRlqwtSTDGLGVLIISPTRELAYQTFE 159
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDL----ERRHPQVLILAPTREIAVQIHD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 160 VLRKVGKN-HDFSAGLIIGGKDLKHEAERINNINILVCTPGRLLqHMDETVSFHATDLQMLVLDEADRILDMGFADTMNA 238
Cdd:cd17943 77 VFKKIGKKlEGLKCEVFIGGTPVKEDKKKLKGCHIAVGTPGRIK-QLIELGALNVSHVRLFVLDEADKLMEGSFQKDVNW 155
|
170 180 190
....*....|....*....|....*....|....*.
gi 13514831 239 VIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 274
Cdd:cd17943 156 IFSSLPKNKQVIAFSATYPKNLDNLLARYMRKPVLV 191
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
59-430 |
2.49e-37 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 144.97 E-value: 2.49e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 59 NYEKInvneITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFlvpVLEALYRLQWtS 138
Cdd:PTZ00424 22 NYDEI----VDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATF---VIAALQLIDY-D 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 139 TDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQHMDETvSFHATDLQ 217
Cdd:PTZ00424 94 LNACQALILAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAgVHMVVGTPGRVYDMIDKR-HLRVDDLK 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 218 MLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYVWVheKAKYSTPATLEQNYIVCEL 297
Cdd:PTZ00424 173 LFILDEADEMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILV--KKDELTLEGIRQFYVAVEK 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 298 QQ-KISVLYSFLRSHLKKKSIVFFSSCKEVQYLYRVFCRLRPGVSilALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAA 376
Cdd:PTZ00424 251 EEwKFDTLCDLYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVS--CMHGDMDQKDRDLIMREFRSGSTRVLITTDLLA 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 13514831 377 RGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILLPSEKAMVQQL 430
Cdd:PTZ00424 329 RGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEI 382
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
71-276 |
4.02e-37 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 138.22 E-value: 4.02e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 71 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYrlqwtstdglgVLIISPT 150
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVV-----------ALILEPS 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 151 RELAYQTFEVLRKVGK---NHDFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQhMDETVSFHATDLQMLVLDEADR 226
Cdd:cd17938 70 RELAEQTYNCIENFKKyldNPKLRVALLIGGVKAREQLKRLeSGVDIVVGTPGRLED-LIKTGKLDLSSVRFFVLDEADR 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 13514831 227 ILDMGFADTMNAVIENLPK-----KR-QTLLFSAT-QTKSVKDLARLSLKNPeyVWV 276
Cdd:cd17938 149 LLSQGNLETINRIYNRIPKitsdgKRlQVIVCSATlHSFEVKKLADKIMHFP--TWV 203
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
81-289 |
4.31e-37 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 139.30 E-value: 4.31e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 81 LKGLQEAQYRLVTEIQKQTIGLAL-QGKDVLGAAKTGSGKTLAFLVPVLEALYRLQ-----WTSTDGLGVLIISPTRELA 154
Cdd:cd17946 2 LRALADLGFSEPTPIQALALPAAIrDGKDVIGAAETGSGKTLAFGIPILERLLSQKssngvGGKQKPLRALILTPTRELA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 155 YQTFEVLRKVGKNHDFSAGLIIGG-------KDLKHEAErinninILVCTPGRLLQHMDETVSFHAT--DLQMLVLDEAD 225
Cdd:cd17946 82 VQVKDHLKAIAKYTNIKIASIVGGlavqkqeRLLKKRPE------IVVATPGRLWELIQEGNEHLANlkSLRFLVLDEAD 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13514831 226 RILDMG-FA------DTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNpeyvwvhEKAKYSTPATLE 289
Cdd:cd17946 156 RMLEKGhFAelekilELLNKDRAGKKRKRQTFVFSATLTLDHQLPLKLNSKK-------KKKKKEKKQKLE 219
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
59-270 |
4.58e-36 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 136.71 E-value: 4.58e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 59 NYEKINVN--------EITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEA 130
Cdd:cd18051 3 KYEDIPVEatgencppHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 131 LY-----RLQWTSTDGLG-------VLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLK---HEAERinNINILV 195
Cdd:cd18051 83 IYeqgpgESLPSESGYYGrrkqyplALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGqqmRDLER--GCHLLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 196 CTPGRLLQHMD------ETVSFhatdlqmLVLDEADRILDMGFADTMNAVIE--NLPKK--RQTLLFSATQTKSVKDLAR 265
Cdd:cd18051 161 ATPGRLVDMLErgkiglDYCKY-------LVLDEADRMLDMGFEPQIRRIVEqdTMPPTgeRQTLMFSATFPKEIQMLAR 233
|
....*
gi 13514831 266 LSLKN 270
Cdd:cd18051 234 DFLDN 238
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
60-274 |
4.71e-35 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 133.53 E-value: 4.71e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 60 YEKINVNEITRFsdFPLSKKTLKGLQEAQyrlvteiqkqTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSt 139
Cdd:cd17956 2 LKNLQNNGITSA--FPVQAAVIPWLLPSS----------KSTPPYRPGDLCVSAPTGSGKTLAYVLPIVQALSKRVVPR- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 140 dgLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERI---------NNINILVCTPGRLLQHMDETVS 210
Cdd:cd17956 69 --LRALIVVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLlvdtsgrylSRVDILVATPGRLVDHLNSTPG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 211 FHATDLQMLVLDEADRILDMGFADTMNAVIENL--------------------PKKRQTLLFSATQTKSVKDLARLSLKN 270
Cdd:cd17956 147 FTLKHLRFLVIDEADRLLNQSFQDWLETVMKALgrptapdlgsfgdanllersVRPLQKLLFSATLTRDPEKLSSLKLHR 226
|
....
gi 13514831 271 PEYV 274
Cdd:cd17956 227 PRLF 230
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
84-271 |
5.11e-33 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 126.12 E-value: 5.11e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 84 LQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVL-EALyrlqwTSTDGLGVLIISPTRELAYQTFEVLR 162
Cdd:cd17962 5 LKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIiRCL-----TEHRNPSALILTPTRELAVQIEDQAK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 163 KVGKNH-DFSAGLIIGGKDLKHEAERI-NNINILVCTPGRLLQHMDE-TVSFHatDLQMLVLDEADRILDMGFADTMNAV 239
Cdd:cd17962 80 ELMKGLpPMKTALLVGGLPLPPQLYRLqQGVKVIIATPGRLLDILKQsSVELD--NIKIVVVDEADTMLKMGFQQQVLDI 157
|
170 180 190
....*....|....*....|....*....|..
gi 13514831 240 IENLPKKRQTLLFSATQTKSVKDLARLSLKNP 271
Cdd:cd17962 158 LENISHDHQTILVSATIPRGIEQLAGQLLQNP 189
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
76-271 |
4.29e-32 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 123.45 E-value: 4.29e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 76 LSKKTLKGLQEAQYRLVTEIQKQTIGLALQG--KDVLGAAKTGSGKTLAFLVPVLEAL-YRLQWTStdglgVLIISPTRE 152
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVdPTLKSPQ-----ALCLAPTRE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 153 LAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEaERINNiNILVCTPGRLLQHMDeTVSFHATDLQMLVLDEADRILDM-G 231
Cdd:cd17963 76 LARQIGEVVEKMGKFTGVKVALAVPGNDVPRG-KKITA-QIVIGTPGTVLDWLK-KRQLDLKKIKILVLDEADVMLDTqG 152
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 13514831 232 FADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 271
Cdd:cd17963 153 HGDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNA 192
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
73-271 |
1.03e-31 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 122.82 E-value: 1.03e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 73 DFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYrlqwTSTDGLGVLIISPTRE 152
Cdd:cd17939 1 DMGLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRID----TTVRETQALVLAPTRE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 153 LAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERIN-NINILVCTPGRLLqHMDETVSFHATDLQMLVLDEADRILDMG 231
Cdd:cd17939 77 LAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQyGPHIVVGTPGRVF-DMLQRRSLRTDKIKMFVLDEADEMLSRG 155
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 13514831 232 FADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 271
Cdd:cd17939 156 FKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDP 195
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
81-274 |
7.48e-30 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 117.18 E-value: 7.48e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 81 LKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPvleALYRLQWTST-----DGLGVLIISPTRELAY 155
Cdd:cd17958 2 MKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLP---GFIHLDLQPIpreqrNGPGVLVLTPTRELAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 156 QTFEVLRKVGKNhDFSAGLIIGGKDLKHEAERINN-INILVCTPGRL--LQhMDETVSFhaTDLQMLVLDEADRILDMGF 232
Cdd:cd17958 79 QIEAECSKYSYK-GLKSVCVYGGGNRNEQIEDLSKgVDIIIATPGRLndLQ-MNNVINL--KSITYLVLDEADRMLDMGF 154
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 13514831 233 ADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 274
Cdd:cd17958 155 EPQIRKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
68-277 |
3.99e-29 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 116.26 E-value: 3.99e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 68 ITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTST-DGLGVLI 146
Cdd:cd18049 23 VLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERgDGPICLV 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 147 ISPTRELAYQTFEVLRKVGKNHDFSAGLIIGG-------KDLKHEAErinninILVCTPGRLLQHMdETVSFHATDLQML 219
Cdd:cd18049 103 LAPTRELAQQVQQVAAEYGRACRLKSTCIYGGapkgpqiRDLERGVE------ICIATPGRLIDFL-EAGKTNLRRCTYL 175
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 13514831 220 VLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKnpEYVWVH 277
Cdd:cd18049 176 VLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLK--DYIHIN 231
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
68-270 |
2.13e-28 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 115.49 E-value: 2.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 68 ITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTST-DGLGVLI 146
Cdd:cd18050 61 VFAFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERgDGPICLV 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 147 ISPTRELAYQTFEVLRKVGKNHDFSAGLIIGG-------KDLKHEAErinninILVCTPGRLLQHMdETVSFHATDLQML 219
Cdd:cd18050 141 LAPTRELAQQVQQVADDYGKSSRLKSTCIYGGapkgpqiRDLERGVE------ICIATPGRLIDFL-EAGKTNLRRCTYL 213
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 13514831 220 VLDEADRILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKN 270
Cdd:cd18050 214 VLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRD 264
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
80-269 |
6.38e-28 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 111.86 E-value: 6.38e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 80 TLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLG--VLIISPTRELAYQT 157
Cdd:cd17944 1 TIKLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRGRApkVLVLAPTRELANQV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 158 FEVLRKVGKNhdFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQHMdETVSFHATDLQMLVLDEADRILDMGFADTM 236
Cdd:cd17944 81 TKDFKDITRK--LSVACFYGGTPYQQQIFAIRNgIDILVGTPGRIKDHL-QNGRLDLTKLKHVVLDEVDQMLDMGFAEQV 157
|
170 180 190
....*....|....*....|....*....|....*...
gi 13514831 237 NAVIENLPKKR-----QTLLFSATQTKSVKDLARLSLK 269
Cdd:cd17944 158 EEILSVSYKKDsednpQTLLFSATCPDWVYNVAKKYMK 195
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
299-410 |
3.92e-26 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 103.44 E-value: 3.92e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 299 QKISVLYSFLRSHLKKKSIVFFSSCKEVQYlyrVFCRLRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARG 378
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTLEA---ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERG 77
|
90 100 110
....*....|....*....|....*....|..
gi 13514831 379 LDFPAVNWVLQFDCPEDANTYIHRAGRTARYK 410
Cdd:pfam00271 78 LDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
71-271 |
7.16e-26 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 106.01 E-value: 7.16e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 71 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALyRLQWTSTDglgVLIISPT 150
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCL-DIQVRETQ---ALILSPT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 151 RELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQhMDETVSFHATDLQMLVLDEADRILD 229
Cdd:cd18045 77 RELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYgQHIVSGTPGRVFD-MIRRRSLRTRHIKMLVLDEADEMLN 155
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 13514831 230 MGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 271
Cdd:cd18045 156 KGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDP 197
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
69-276 |
7.78e-26 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 105.89 E-value: 7.78e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 69 TRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYrlqwTSTDGLGVLIIS 148
Cdd:cd17950 2 SGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLE----PVDGQVSVLVIC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 149 PTRELAYQ-TFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINNI--NILVCTPGRLLQHMDETvSFHATDLQMLVLDEAD 225
Cdd:cd17950 78 HTRELAFQiSNEYERFSKYMPNVKTAVFFGGVPIKKDIEVLKNKcpHIVVGTPGRILALVREK-KLKLSHVKHFVLDECD 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 13514831 226 RILDmgfADTMNAVIENL----PKKRQTLLFSATQTKSVKDLARLSLKNPEYVWV 276
Cdd:cd17950 157 KMLE---QLDMRRDVQEIfratPHDKQVMMFSATLSKEIRPVCKKFMQDPLEIFV 208
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
71-271 |
4.03e-25 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 103.68 E-value: 4.03e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 71 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYrlqwTSTDGLGVLIISPT 150
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQID----TSLKATQALVLAPT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 151 RELAYQTFEVLRKVGKNHDFSAGLIIGGKDLKHEAERINN-INILVCTPGRLLQHMDETVsFHATDLQMLVLDEADRILD 229
Cdd:cd18046 77 RELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAgPHIVVGTPGRVFDMINRRY-LRTDYIKMFVLDEADEMLS 155
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 13514831 230 MGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNP 271
Cdd:cd18046 156 RGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDP 197
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
84-263 |
2.16e-24 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 102.44 E-value: 2.16e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 84 LQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALyrLQWTSTDGLG-----VLIISPTRELAYQTF 158
Cdd:cd17948 5 LQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRL--LRYKLLAEGPfnaprGLVITPSRELAEQIG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 159 EVLRKVGKNHDFSAGLIIGGKDLKheaeRINN-----INILVCTPGRLLQHMdeTVSFHATD-LQMLVLDEADRILDMGF 232
Cdd:cd17948 83 SVAQSLTEGLGLKVKVITGGRTKR----QIRNphfeeVDILVATPGALSKLL--TSRIYSLEqLRHLVLDEADTLLDDSF 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 13514831 233 ADTM-------------NAVIENLPKKRQTLLFSATQTKSVKDL 263
Cdd:cd17948 157 NEKLshflrrfplasrrSENTDGLDPGTQLVLVSATMPSGVGEV 200
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
106-255 |
4.38e-22 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 93.24 E-value: 4.38e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 106 GKDVLGAAKTGSGKTLAFLVPVLEALyrlqwtSTDGLGVLIISPTRELAYQTFEVLRKVGKnHDFSAGLIIGGKDLKH-E 184
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAALLLL------LKKGKKVLVLVPTKALALQTAERLRELFG-PGIRVAVLVGGSSAEErE 73
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13514831 185 AERINNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRIL-DMGFADTMNAVIENLPKKR-QTLLFSAT 255
Cdd:cd00046 74 KNKLGDADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALLiDSRGALILDLAVRKAGLKNaQVILLSAT 146
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
106-534 |
2.91e-21 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 98.94 E-value: 2.91e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 106 GKDVLGAAKTGSGKTLAFLvpvlEALYRLQWTSTdglgVLIISPTRELAYQTFEVLRKVGKNHDFSAGliiggkdlKHEA 185
Cdd:COG1061 100 GGRGLVVAPTGTGKTVLAL----ALAAELLRGKR----VLVLVPRRELLEQWAEELRRFLGDPLAGGG--------KKDS 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 186 ERinniNILVCTPGRLLQHMDETVSFHATDLqmLVLDEADRIldmgFADTMNAVIENLPKKRqTLLFSAT---------- 255
Cdd:COG1061 164 DA----PITVATYQSLARRAHLDELGDRFGL--VIIDEAHHA----GAPSYRRILEAFPAAY-RLGLTATpfrsdgreil 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 256 --------QTKSVKDLARLS-LKNPEYV-----WVHEKAKYSTPATLEQNYIVCELQQKISVLYSFLRSHLK-KKSIVFF 320
Cdd:COG1061 233 lflfdgivYEYSLKEAIEDGyLAPPEYYgirvdLTDERAEYDALSERLREALAADAERKDKILRELLREHPDdRKTLVFC 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 321 SSCKEVQYLYRVFCRLrpGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYI 400
Cdd:COG1061 313 SSVDHAEALAELLNEA--GIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFI 390
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 401 HRAGRTARYKEDGEALLILL--PSEKAMVQQLLQKKVPVKEIKINPEKLIDVQKKLESILAQDQDLKERAQRCFVSYVRS 478
Cdd:COG1061 391 QRLGRGLRPAPGKEDALVYDfvGNDVPVLEELAKDLRDLAGYRVEFLDEEESEELALLIAVKPALEVKGELEEELLEELE 470
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 13514831 479 VYLMKDKEVFDVSKLPIPEYALSLGLAVAPRVRFLQKMQKQPTKELVRSQADKVIE 534
Cdd:COG1061 471 LLEDALLLVLAELLLLELLALALELLELAKAEGKAEEEEEEKELLLLLALAKLLKL 526
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
327-410 |
1.17e-19 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 84.19 E-value: 1.17e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 327 QYLYRVFCRLrpGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRT 406
Cdd:smart00490 1 EELAELLKEL--GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 13514831 407 ARYK 410
Cdd:smart00490 79 GRAG 82
|
|
| DUF4217 |
pfam13959 |
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many ... |
451-509 |
6.26e-17 |
|
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many helicase proteins.
Pssm-ID: 464056 [Multi-domain] Cd Length: 59 Bit Score: 75.51 E-value: 6.26e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13514831 451 QKKLESILAQDQDLKERAQRCFVSYVR--SVYLMKDkeVFDVSKLPIPEYALSLGLAVAPR 509
Cdd:pfam13959 1 QLQLEKLVLKDRELKELAQKAFVSYVRaySKHLAKS--IFNVKKLDLGHLAKSFGLLRAPK 59
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
112-259 |
1.61e-16 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 80.11 E-value: 1.61e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 112 AAKTGSGKTLAFLVPVLEALYR--LQWTSTDGLG-----------VLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGG 178
Cdd:cd17965 67 AAETGSGKTLAYLAPLLDYLKRqeQEPFEEAEEEyesakdtgrprSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSG 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 179 KDLKHE--AERINN-INILVCTPGrLLQHMDETVSFHATDLQMLVLDEADRILDMGFADTMNAVIENLPKKRQTLLFSAT 255
Cdd:cd17965 147 FGPSYQrlQLAFKGrIDILVTTPG-KLASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSAT 225
|
....
gi 13514831 256 QTKS 259
Cdd:cd17965 226 IPKE 229
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
68-274 |
1.17e-14 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 74.29 E-value: 1.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 68 ITRFSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQG--KDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTdglgVL 145
Cdd:cd18048 17 VKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLYPQ----CL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 146 IISPTRELAYQTFEVLRKVGKnhdFSAGLII--------GGKDLKHEAErinninILVCTPGRLLQHMDETVSFHATDLQ 217
Cdd:cd18048 93 CLSPTFELALQTGKVVEEMGK---FCVGIQViyairgnrPGKGTDIEAQ------IVIGTPGTVLDWCFKLRLIDVTNIS 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 13514831 218 MLVLDEADRILDM-GFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 274
Cdd:cd18048 164 VFVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNII 221
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
71-274 |
4.62e-14 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 72.06 E-value: 4.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 71 FSDFPLSKKTLKGLQEAQYRLVTEIQKQTIGLALQG--KDVLGAAKTGSGKTLAFLVPVLEAL-YRLQWTStdglgVLII 147
Cdd:cd18047 3 FEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVePANKYPQ-----CLCL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 148 SPTRELAYQTFEVLRKVGKnhdFSAGLIIGGKDLKHEAERINNI--NILVCTPGRLLQHMDETVSFHATDLQMLVLDEAD 225
Cdd:cd18047 78 SPTYELALQTGKVIEQMGK---FYPELKLAYAVRGNKLERGQKIseQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEAD 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 13514831 226 -RILDMGFADTMNAVIENLPKKRQTLLFSATQTKSVKDLARLSLKNPEYV 274
Cdd:cd18047 155 vMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVI 204
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
113-421 |
2.06e-13 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 72.46 E-value: 2.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 113 AKTGSGKTLAFLvpvLEALYRLQWTSTDGlgVLIISPTRELAYQTFEVLRKVGKnHDFSAGLIIGGKDLKH-----EAER 187
Cdd:cd09639 6 APTGYGKTEAAL---LWALHSLKSQKADR--VIIALPTRATINAMYRRAKEAFG-ETGLYHSSILSSRIKEmgdseEFEH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 188 INNIN-----------ILVCTPGRLLQHMDETVSFHATDL-----QMLVLDEADRILD--MGFadtMNAVIENLPKKRQT 249
Cdd:cd09639 80 LFPLYihsndtlfldpITVCTIDQVLKSVFGEFGHYEFTLasianSLLIFDEVHFYDEytLAL---ILAVLEVLKDNDVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 250 -LLFSATQTKSVKDLARlslkNPEYVWVHEKAKYSTPATLEQNYIVCELQQKISVLYSFLRSHLKKKSI-VFFSSCKEVQ 327
Cdd:cd09639 157 iLLMSATLPKFLKEYAE----KIGYVEENEPLDLKPNERAPFIKIESDKVGEISSLERLLEFIKKGGSVaIIVNTVDRAQ 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 328 YLYRVFCRLRPGVSILALHGRQQQMRRM----EVYNEFVRKRAAVLFATDIAARGLDFpAVNWVLQFDCPEDAntYIHRA 403
Cdd:cd09639 233 EFYQQLKEKGPEEEIMLIHSRFTEKDRAkkeaELLLEFKKSEKFVIVATQVIEASLDI-SVDVMITELAPIDS--LIQRL 309
|
330
....*....|....*....
gi 13514831 404 GRTARY-KEDGEALLILLP 421
Cdd:cd09639 310 GRLHRYgEKNGEEVYIITD 328
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
96-447 |
7.33e-11 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 65.89 E-value: 7.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 96 QKQTIGLALQGKDVLGAAKTGSGKTLAFLVPvleALYRlqwtstDGLgVLIISPTRELAYQTFEVLRKVGknhdFSAGLI 175
Cdd:PRK11057 30 QQEIIDAVLSGRDCLVVMPTGGGKSLCYQIP---ALVL------DGL-TLVVSPLISLMKDQVDQLLANG----VAAACL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 176 IGGKDLKHEAERIN-----NINILVCTPGRLLqhMDETV-SFHATDLQMLVLDEADRILDMG--FADTMNAV------IE 241
Cdd:PRK11057 96 NSTQTREQQLEVMAgcrtgQIKLLYIAPERLM--MDNFLeHLAHWNPALLAVDEAHCISQWGhdFRPEYAALgqlrqrFP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 242 NLPkkrqTLLFSATQTKSV-KDLAR-LSLKNP-EYVwvhekAKYSTPATleqNYIVCELQQKISVLYSFLRSHLKKKSIV 318
Cdd:PRK11057 174 TLP----FMALTATADDTTrQDIVRlLGLNDPlIQI-----SSFDRPNI---RYTLVEKFKPLDQLMRYVQEQRGKSGII 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 319 FFSSCKEVQYLYRVFCRlrPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANT 398
Cdd:PRK11057 242 YCNSRAKVEDTAARLQS--RGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIES 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 13514831 399 YIHRAGRTARykeDG---EALLILLPSEKAMVQQLLQKKVPVKEIKINPEKL 447
Cdd:PRK11057 320 YYQETGRAGR---DGlpaEAMLFYDPADMAWLRRCLEEKPAGQQQDIERHKL 368
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
96-459 |
8.64e-11 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 65.16 E-value: 8.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 96 QKQTIGLALQGKDVLGAAKTGSGKTLAFLVPvleALYRlqwtstDGLGVlIISPtreL---------AyqtfevLRKVGk 166
Cdd:COG0514 22 QEEIIEAVLAGRDALVVMPTGGGKSLCYQLP---ALLL------PGLTL-VVSP---LialmkdqvdA------LRAAG- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 167 nhdFSAGLIIGGKDLKHEAERINNIN-----ILVCTPGRLLQhmDETVSF-HATDLQMLVLDEA--------D------R 226
Cdd:COG0514 82 ---IRAAFLNSSLSAEERREVLRALRagelkLLYVAPERLLN--PRFLELlRRLKISLFAIDEAhcisqwghDfrpdyrR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 227 IldmgfadtmNAVIENLPkKRQTLLFSATQTKSVKD--LARLSLKNPEyVWVH----EKAKYSTpatleqnyIVCELQQK 300
Cdd:COG0514 157 L---------GELRERLP-NVPVLALTATATPRVRAdiAEQLGLEDPR-VFVGsfdrPNLRLEV--------VPKPPDDK 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 301 ISVLYSFLRSHLKKKSIVFFSSCKEVQYLYRvfcRLRP-GVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATdIA-ARG 378
Cdd:COG0514 218 LAQLLDFLKEHPGGSGIVYCLSRKKVEELAE---WLREaGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT-IAfGMG 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 379 LDFPAVNWVLQFDCPEDANTY---IHRAGRtarykeDGE-ALLILLPSEK--AMVQQLLQKKVPVKEIKINpeklidVQK 452
Cdd:COG0514 294 IDKPDVRFVIHYDLPKSIEAYyqeIGRAGR------DGLpAEALLLYGPEdvAIQRFFIEQSPPDEERKRV------ERA 361
|
....*..
gi 13514831 453 KLESILA 459
Cdd:COG0514 362 KLDAMLA 368
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
96-224 |
1.66e-10 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 61.06 E-value: 1.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 96 QKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRlQWTSTdglgVLIISPTRELAYQTFEVLRKVgkNHDFSAGLI 175
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLR-DPGSR----ALYLYPTKALAQDQLRSLREL--LEQLGLGIR 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 13514831 176 IG---GkDLKHEAER---INNINILVCTPGRL----LQHMDETVSFhATDLQMLVLDEA 224
Cdd:cd17923 78 VAtydG-DTPREERRaiiRNPPRILLTNPDMLhyalLPHHDRWARF-LRNLRYVVLDEA 134
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
91-265 |
1.84e-09 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 58.04 E-value: 1.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 91 LVTEIQKQTI-GLALQGKDVLGAAKTGSGKTLAflvpVLEALYRLqWTSTDGLgVLIISPTRELAYQTFEVLRKVGKNHD 169
Cdd:cd17921 1 LLNPIQREALrALYLSGDSVLVSAPTSSGKTLI----AELAILRA-LATSGGK-AVYIAPTRALVNQKEADLRERFGPLG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 170 FSAGLIIGgkDLKHEAERINNINILVCTP----GRLLQHMDETVSfhatDLQMLVLDEADRILDMGFADTMNAVIENLP- 244
Cdd:cd17921 75 KNVGLLTG--DPSVNKLLLAEADILVATPekldLLLRNGGERLIQ----DVRLVVVDEAHLIGDGERGVVLELLLSRLLr 148
|
170 180
....*....|....*....|...
gi 13514831 245 --KKRQTLLFSATqTKSVKDLAR 265
Cdd:cd17921 149 inKNARFVGLSAT-LPNAEDLAE 170
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
86-155 |
6.58e-09 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 59.73 E-value: 6.58e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13514831 86 EAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLA-FLvPVLEALYRLQWTST--DGLGVLIISPTRELAY 155
Cdd:COG1201 19 AARFGAPTPPQREAWPAIAAGESTLLIAPTGSGKTLAaFL-PALDELARRPRPGElpDGLRVLYISPLKALAN 90
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
96-224 |
1.39e-08 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 58.69 E-value: 1.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 96 QKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRlQWTSTdglgVLIISPTRELAYQTFEVLRKVGKNH--DFSAG 173
Cdd:COG1205 61 QAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEALLE-DPGAT----ALYLYPTKALARDQLRRLRELAEALglGVRVA 135
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 13514831 174 LIIGGKDlKHEAERI-NNINILVCTP-----GrLLQHMDETVSFHATdLQMLVLDEA 224
Cdd:COG1205 136 TYDGDTP-PEERRWIrEHPDIVLTNPdmlhyG-LLPHHTRWARFFRN-LRYVVIDEA 189
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
362-421 |
1.68e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 52.32 E-value: 1.68e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 362 VRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDgEALLILLP 421
Cdd:cd18785 19 IASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKD-EGEVILFV 77
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
115-255 |
5.62e-08 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 52.69 E-value: 5.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 115 TGSGKTLaFLVPVLEALYRLqwtstdglGVLIISPTRELAYQTFEVLRKVGKNHDFSaglIIGGKDLKHeaerINNINIL 194
Cdd:cd17926 27 TGSGKTL-TALALIAYLKEL--------RTLIVVPTDALLDQWKERFEDFLGDSSIG---LIGGGKKKD----FDDANVV 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13514831 195 VCTPGRLLQHMDETVSFHATDLQMLVlDEADRILdmgfADTMNAVIENLPKKRQtLLFSAT 255
Cdd:cd17926 91 VATYQSLSNLAEEEKDLFDQFGLLIV-DEAHHLP----AKTFSEILKELNAKYR-LGLTAT 145
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
115-255 |
9.13e-08 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 52.67 E-value: 9.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 115 TGSGKTLAFLvpvleALYRLQWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDLkheaERINNINIL 194
Cdd:pfam04851 32 TGSGKTLTAA-----KLIARLFKKGPIKKVLFLVPRKDLLEQALEEFKKFLPNYVEIGEIISGDKKD----ESVDDNKIV 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13514831 195 VCTPGRLLQHMDETVSFHATDLQMLVL-DEADRildmGFADTMNAVIENLPKKRQtLLFSAT 255
Cdd:pfam04851 103 VTTIQSLYKALELASLELLPDFFDVIIiDEAHR----SGASSYRNILEYFKPAFL-LGLTAT 159
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
106-163 |
9.51e-08 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 52.59 E-value: 9.51e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 13514831 106 GKDVLGAAKTGSGKTLAFLVPVLEALYRLQWtstDGLGVLIISPTRELAYQTFEVLRK 163
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPE---KGVQVLYISPLKALINDQERRLEE 55
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
96-265 |
2.89e-07 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 54.13 E-value: 2.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 96 QKQTI--GLaLQGKDVLGAAKTGSGKTL-AFLvPVLEALyrlqwtsTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSA 172
Cdd:COG1204 27 QAEALeaGL-LEGKNLVVSAPTASGKTLiAEL-AILKAL-------LNGGKALYIVPLRALASEKYREFKRDFEELGIKV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 173 GLIIGGKDLkhEAERINNINILVCTPGRLLQHMDETVSFhATDLQMLVLDEADRILDMGFADTMNAVIENL---PKKRQT 249
Cdd:COG1204 98 GVSTGDYDS--DDEWLGRYDILVATPEKLDSLLRNGPSW-LRDVDLVVVDEAHLIDDESRGPTLEVLLARLrrlNPEAQI 174
|
170
....*....|....*.
gi 13514831 250 LLFSATqTKSVKDLAR 265
Cdd:COG1204 175 VALSAT-IGNAEEIAE 189
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
96-278 |
3.98e-06 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 48.30 E-value: 3.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 96 QKQTIGLALQGKDVLGAAKTGSGKTLAFLVPvleALYRlqwtstDGLgVLIISPTreLAYQTFEVLRKvgKNHDFSAGLI 175
Cdd:cd17920 17 QLEAINAVLAGRDVLVVMPTGGGKSLCYQLP---ALLL------DGV-TLVVSPL--ISLMQDQVDRL--QQLGIRAAAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 176 IGGKDLKHEAERINNI-----NILVCTPGRLLQ-HMDETVS--FHATDLQMLVLDEADRIL--------DMGFadtMNAV 239
Cdd:cd17920 83 NSTLSPEEKREVLLRIkngqyKLLYVTPERLLSpDFLELLQrlPERKRLALIVVDEAHCVSqwghdfrpDYLR---LGRL 159
|
170 180 190
....*....|....*....|....*....|....*....
gi 13514831 240 IENLPKKrQTLLFSATQTKSVKDLARLSLKNPEYVWVHE 278
Cdd:cd17920 160 RRALPGV-PILALTATATPEVREDILKRLGLRNPVIFRA 197
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
96-260 |
4.69e-06 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 48.41 E-value: 4.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 96 QKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLeaLYRLQwtsTDGLGvLIISPTREL-AYQTFEVLRKVgknhdfSAGL 174
Cdd:cd18018 17 QEEAIARLLSGRSTLVVLPTGAGKSLCYQLPAL--LLRRR---GPGLT-LVVSPLIALmKDQVDALPRAI------KAAA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 175 IIGG---KDLKHEAERINN--INILVCTPGRLLQHMDETVSFHATDLQMLVLDEADRILDMGFA---DTM--NAVIENLP 244
Cdd:cd18018 85 LNSSltrEERRRILEKLRAgeVKILYVSPERLVNESFRELLRQTPPISLLVVDEAHCISEWSHNfrpDYLrlCRVLRELL 164
|
170
....*....|....*.
gi 13514831 245 KKRQTLLFSATQTKSV 260
Cdd:cd18018 165 GAPPVLALTATATKRV 180
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
103-226 |
4.73e-06 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 48.20 E-value: 4.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 103 ALQGKDVLGAAKTGSGKTlafLVPVLEALYRLQWTSTDGLG-VLIISPTRELAYQTFEVLRKVGKNHDFSAGLIIGGKDL 181
Cdd:cd17927 14 ALKGKNTIICLPTGSGKT---FVAVLICEHHLKKFPAGRKGkVVFLANKVPLVEQQKEVFRKHFERPGYKVTGLSGDTSE 90
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 13514831 182 KHEAER-INNINILVCTPGRLLQHMDETVSFHATDLQMLVLDEADR 226
Cdd:cd17927 91 NVSVEQiVESSDVIIVTPQILVNDLKSGTIVSLSDFSLLVFDECHN 136
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
348-408 |
1.54e-05 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 45.66 E-value: 1.54e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13514831 348 RQQQmrrmEVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRtAR 408
Cdd:cd18802 77 RKQK----ETLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-AR 132
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
108-255 |
1.89e-05 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 46.26 E-value: 1.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 108 DVLGAAKTGSGKTLAFLVPVLEALYRlqwtstdGLGVLIISPTRELAYQTFEVLRKVGKnhDFSAGLIIGGKDLKHEAEr 187
Cdd:cd17918 38 DRLLSGDVGSGKTLVALGAALLAYKN-------GKQVAILVPTEILAHQHYEEARKFLP--FINVELVTGGTKAQILSG- 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13514831 188 innINILVCTPGrLLQhmdETVSFHATDLqmLVLDEADRildmgFADTMNAVIENLpKKRQTLLFSAT 255
Cdd:cd17918 108 ---ISLLVGTHA-LLH---LDVKFKNLDL--VIVDEQHR-----FGVAQREALYNL-GATHFLEATAT 160
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
115-224 |
5.57e-05 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 44.95 E-value: 5.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 115 TGSGKTL-AFLvpVLEALYRLQ-WTSTDGLGVLIISPTRELAYQTFEVLR-----KVGKnhdFSAGLIIGGKDLKHEAER 187
Cdd:cd18034 25 TGSGKTLiAVM--LIKEMGELNrKEKNPKKRAVFLVPTVPLVAQQAEAIRshtdlKVGE---YSGEMGVDKWTKERWKEE 99
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 13514831 188 INNINILVCTPGRL---LQHMDETVSfhatDLQMLVLDEA 224
Cdd:cd18034 100 LEKYDVLVMTAQILldaLRHGFLSLS----DINLLIFDEC 135
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
88-154 |
6.07e-05 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 46.80 E-value: 6.07e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13514831 88 QYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRL--QWTSTDGLGVLIISPTRELA 154
Cdd:PRK13767 29 KFGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIIDELFRLgrEGELEDKVYCLYVSPLRALN 97
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
93-228 |
9.66e-05 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 44.24 E-value: 9.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 93 TEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLealyrlqWTSTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSA 172
Cdd:cd17924 19 WGAQRTWAKRLLRGKSFAIIAPTGVGKTTFGLATSL-------YLASKGKRSYLIFPTKSLVKQAYERLSKYAEKAGVEV 91
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13514831 173 GLIIGGKDLKHEA-----ERINN--INILVCTPGRLLQHMDETVSFhatDLQMLVLDEADRIL 228
Cdd:cd17924 92 KILVYHSRLKKKEkeellEKIEKgdFDILVTTNQFLSKNFDLLSNK---KFDFVFVDDVDAVL 151
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
95-226 |
1.07e-04 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 44.04 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 95 IQKQTIGLALQGKDVLGAAKTGSGKTLaflVPVLEALYRLQwtsTDGLGVLIISPTRELAYQTFEVLRKVGKNHDFSAGL 174
Cdd:cd18035 5 LYQVLIAAVALNGNTLIVLPTGLGKTI---IAILVAADRLT---KKGGKVLILAPSRPLVEQHAENLKRVLNIPDKITSL 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 13514831 175 iIGGKDLKHEAERINNINILVCTPgrllQHMDETV---SFHATDLQMLVLDEADR 226
Cdd:cd18035 79 -TGEVKPEERAERWDASKIIVATP----QVIENDLlagRITLDDVSLLIFDEAHH 128
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
308-433 |
4.17e-04 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 41.56 E-value: 4.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 308 LRSHLKKKSIVFF--SSCKEVQYLYRVFCRLRPGVSILALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVN 385
Cdd:cd18810 18 IERELLRGGQVFYvhNRIESIEKLATQLRQLVPEARIAIAHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNAN 97
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 13514831 386 WVLQfdcpEDANTY----IHR-AGRTARYKEDGEALLiLLPSEKAMVQQLLQK 433
Cdd:cd18810 98 TIII----ERADKFglaqLYQlRGRVGRSKERAYAYF-LYPDQKKLTEDALKR 145
|
|
| VirD4 |
COG3505 |
Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase [Intracellular trafficking, ... |
109-166 |
5.84e-04 |
|
Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442728 [Multi-domain] Cd Length: 402 Bit Score: 43.05 E-value: 5.84e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 13514831 109 VLGAAKTGSGKTLAFLVPVLEALYRlqwtstdGLGVLIISPTRELAYQTFEVLRKVGK 166
Cdd:COG3505 2 VLVIGPTGSGKTVGLVIPNLTQLAR-------GESVVVTDPKGDLAELTAGFRRRAGY 52
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
278-420 |
7.18e-04 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 41.08 E-value: 7.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 278 EKAKYST-PATLEQNYIVCELQQKISVLYSFLRSHLKK-KSIVFfssCKEVQYLYRVFCRLRpgvsILALHGRQQQMRRM 355
Cdd:cd18789 12 FYREYLGlGAHRKRRLLAAMNPNKLRALEELLKRHEQGdKIIVF---TDNVEALYRYAKRLL----KPFITGETPQSERE 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13514831 356 EVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQFdcpedANTY------IHRAGRTARYKEDGEALLILL 420
Cdd:cd18789 85 EILQNFREGEYNTLVVSKVGDEGIDLPEANVAIQI-----SGHGgsrrqeAQRLGRILRPKKGGGKNAFFY 150
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
104-255 |
1.28e-03 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 40.78 E-value: 1.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 104 LQGKDVLGAAKTGSGKTLAFLVPVLEALYRlqwtstdGLGVLIISPTRELA---YQTFEVLRKVGKNHDFSAGliiggkD 180
Cdd:cd18028 15 LKGENLLISIPTASGKTLIAEMAMVNTLLE-------GGKALYLVPLRALAsekYEEFKKLEEIGLKVGISTG------D 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13514831 181 LKHEAERINNINILVCTPGRLlqhmDETVSFHAT---DLQMLVLDEADRILDMGFADTMNAVI---ENLPKKRQTLLFSA 254
Cdd:cd18028 82 YDEDDEWLGDYDIIVATYEKF----DSLLRHSPSwlrDVGVVVVDEIHLISDEERGPTLESIVarlRRLNPNTQIIGLSA 157
|
.
gi 13514831 255 T 255
Cdd:cd18028 158 T 158
|
|
| |
