Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) ...
95-641
0e+00
Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) proteins 1 and 2, which includes the transmembrane and cytosolic regions. These are vertebrate-specific proteins involved in neuronal migration during neurodevelopment. ASTN1 is a neuronal receptor required for neuroblasts migration along glial fibers, especially in the cerebellum. ASTN2 is an endosome membrane protein that binds ASTN1 and mediates its recycling by promoting ASTN1 internalization and transport during its endocytosis.
The actual alignment was detected with superfamily member pfam19441:
Pssm-ID: 437273 Cd Length: 555 Bit Score: 1144.80 E-value: 0e+00
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane ...
917-1134
1.85e-66
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane proteins with a large C-terminal domain, extracellular for ASTN1 and endosome luminal for ASTN-2. They play critical roles in neurodevelopment, and ASTN-2 is also involved in the planar cell polarity pathway in hair cells. This is a domain found in the middle of the C-terminal of ASTN-1 and 2, which comprises a EGF- like domain (EGF4) and a fibronectin type III (Fn(III)) domain. These subdomains are located between the MACPF and annexin- like domains. The structure of Fn(III) from ASTN2 revealed an unexpected feature which has two additional beta strands folded across the core. The junction between EGF-4 and Fn(III) domains in ASTN2 (but not in ASTN1) is thought to be an inositol triphosphate binding site.
The actual alignment was detected with superfamily member pfam19743:
Pssm-ID: 437575 Cd Length: 216 Bit Score: 223.65 E-value: 1.85e-66
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an ...
1145-1237
1.08e-54
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an integral membrane perforin-like protein linked to the planar cell polarity pathway in hair cells. The annexin-like domain is closest in fold to repeat three of human annexin V and similarly binds calcium, yet shares no sequence homology with it. Notably, this ASTN-2 annexin-like domain is closer in structure to human annexin repeat 3 than human annexin repeat 3 is to repeat 1. Annexin-like domains are known for their capacity to remodel membranes, triggered by calcium binding, and have also been suggested to be involved in the formation of pores in membranes both are possible biological roles of the ASTN-2 annexin-like domain.
:
Pssm-ID: 465756 Cd Length: 93 Bit Score: 185.07 E-value: 1.08e-54
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
652-699
3.12e-05
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
:
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 42.23 E-value: 3.12e-05
Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) ...
95-641
0e+00
Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) proteins 1 and 2, which includes the transmembrane and cytosolic regions. These are vertebrate-specific proteins involved in neuronal migration during neurodevelopment. ASTN1 is a neuronal receptor required for neuroblasts migration along glial fibers, especially in the cerebellum. ASTN2 is an endosome membrane protein that binds ASTN1 and mediates its recycling by promoting ASTN1 internalization and transport during its endocytosis.
Pssm-ID: 437273 Cd Length: 555 Bit Score: 1144.80 E-value: 0e+00
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane ...
917-1134
1.85e-66
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane proteins with a large C-terminal domain, extracellular for ASTN1 and endosome luminal for ASTN-2. They play critical roles in neurodevelopment, and ASTN-2 is also involved in the planar cell polarity pathway in hair cells. This is a domain found in the middle of the C-terminal of ASTN-1 and 2, which comprises a EGF- like domain (EGF4) and a fibronectin type III (Fn(III)) domain. These subdomains are located between the MACPF and annexin- like domains. The structure of Fn(III) from ASTN2 revealed an unexpected feature which has two additional beta strands folded across the core. The junction between EGF-4 and Fn(III) domains in ASTN2 (but not in ASTN1) is thought to be an inositol triphosphate binding site.
Pssm-ID: 437575 Cd Length: 216 Bit Score: 223.65 E-value: 1.85e-66
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an ...
1145-1237
1.08e-54
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an integral membrane perforin-like protein linked to the planar cell polarity pathway in hair cells. The annexin-like domain is closest in fold to repeat three of human annexin V and similarly binds calcium, yet shares no sequence homology with it. Notably, this ASTN-2 annexin-like domain is closer in structure to human annexin repeat 3 than human annexin repeat 3 is to repeat 1. Annexin-like domains are known for their capacity to remodel membranes, triggered by calcium binding, and have also been suggested to be involved in the formation of pores in membranes both are possible biological roles of the ASTN-2 annexin-like domain.
Pssm-ID: 465756 Cd Length: 93 Bit Score: 185.07 E-value: 1.08e-54
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
652-699
3.12e-05
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 42.23 E-value: 3.12e-05
Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) ...
95-641
0e+00
Astrotactin 1/2 N-terminal; This entry represents the N-terminal domain of Astrotactin (ASTN) proteins 1 and 2, which includes the transmembrane and cytosolic regions. These are vertebrate-specific proteins involved in neuronal migration during neurodevelopment. ASTN1 is a neuronal receptor required for neuroblasts migration along glial fibers, especially in the cerebellum. ASTN2 is an endosome membrane protein that binds ASTN1 and mediates its recycling by promoting ASTN1 internalization and transport during its endocytosis.
Pssm-ID: 437273 Cd Length: 555 Bit Score: 1144.80 E-value: 0e+00
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane ...
917-1134
1.85e-66
ASTN1/2 EGF-like and Fn(III) domains; Astrotactin-1 and 2 (ASTN1/2) are integral membrane proteins with a large C-terminal domain, extracellular for ASTN1 and endosome luminal for ASTN-2. They play critical roles in neurodevelopment, and ASTN-2 is also involved in the planar cell polarity pathway in hair cells. This is a domain found in the middle of the C-terminal of ASTN-1 and 2, which comprises a EGF- like domain (EGF4) and a fibronectin type III (Fn(III)) domain. These subdomains are located between the MACPF and annexin- like domains. The structure of Fn(III) from ASTN2 revealed an unexpected feature which has two additional beta strands folded across the core. The junction between EGF-4 and Fn(III) domains in ASTN2 (but not in ASTN1) is thought to be an inositol triphosphate binding site.
Pssm-ID: 437575 Cd Length: 216 Bit Score: 223.65 E-value: 1.85e-66
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an ...
1145-1237
1.08e-54
Annexin-like domain; This annexin-like domain can be found in astrotactin 2 (Astn-2), an integral membrane perforin-like protein linked to the planar cell polarity pathway in hair cells. The annexin-like domain is closest in fold to repeat three of human annexin V and similarly binds calcium, yet shares no sequence homology with it. Notably, this ASTN-2 annexin-like domain is closer in structure to human annexin repeat 3 than human annexin repeat 3 is to repeat 1. Annexin-like domains are known for their capacity to remodel membranes, triggered by calcium binding, and have also been suggested to be involved in the formation of pores in membranes both are possible biological roles of the ASTN-2 annexin-like domain.
Pssm-ID: 465756 Cd Length: 93 Bit Score: 185.07 E-value: 1.08e-54
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
652-699
3.12e-05
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.
Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 42.23 E-value: 3.12e-05
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
Click on the triangle to view details about the feature, including a multiple sequence alignment
of your query sequence and the protein sequences used to curate the domain model,
where hash marks (#) above the aligned sequences show the location of the conserved feature residues.
The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
Click on the triangle for interactive 3D structure viewing options.
Functional characterization of the conserved domain architecture found on the query.
Click here to see more details.
This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
(labeled illustration) or all hits
(labeled illustration).
Domains are color coded according to superfamilies
to which they have been assigned. Hits with scores that pass a domain-specific threshold
(specific hits) are drawn in bright colors.
Others (non-specific hits) and
superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features),
they are mapped to the query sequence and indicated through sets of triangles
with the same color and shade of the domain or superfamily that provides the annotation. Mouse over the colored bars or triangles to see descriptions of the domains and features.
click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
mapped to the query sequence.
Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the
advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
(CDART).
Modify your query to search against a different database and/or use advanced search options
