NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|194239733|ref|NP_004165|]
View 

sodium/hydrogen exchanger 3 isoform 1 precursor [Homo sapiens]

Protein Classification

sodium/hydrogen exchanger( domain architecture ID 11489762)

sodium/hydrogen exchanger is a solute carrier family 9 member involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
48-646 0e+00

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


:

Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 787.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733   48 EWAHVQDPYVIALWILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLLPPIVLDA 127
Cdd:TIGR00840   1 DYEHVQSPYEFILWILLASLAKIGFHLTHKVIRAVPESVLLIVYGLLVGGIIKASPHIDPPTLDSSYFFLYLLPPIVLDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  128 GYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNE 207
Cdd:TIGR00840  81 GYFMPQRNFFENLGSILIFAVVGTLINAFVIGLSLYGICLIGGFGSIDIGLLDNLLFGSLISAVDPVAVLAVFEEYHVNE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  208 VLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEP 287
Cdd:TIGR00840 161 KLYIIIFGESLLNDAVTVVLYNTFIKFHKTADEPVTIVDVFEGCASFFVVTCGGLLVGVVFGFLVAFITRFTHHIRQIEP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  288 GFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVNPF-IWTW 366
Cdd:TIGR00840 241 LFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLSSLSETLIFIFLGVSLVTENhEWNW 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  367 ntAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVF 446
Cdd:TIGR00840 321 --AFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPYKFLFVTTTLVVVF 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  447 FTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQK 526
Cdd:TIGR00840 399 FTVIFQGGTIKPLVEVLKVKKGCISKTKINEELHDREFDHLLPGIEDICGQIGHDRAIDKLNGFDIKYLLKPLIRRNSPK 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  527 SRDrILNVFHELNLKDAISYVAEgerrGSLAFIRSPstdnvvnvdftPRSSTVEASvsyllrenvsavcLDMQSLEQrRR 606
Cdd:TIGR00840 479 SSD-IVAVYHKLNLKQAISLVEG----GSLSFVGTN-----------PEPSNSEPI-------------IPALSSED-KE 528
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 194239733  607 SIRDaedmvthhTLQQYLYKPRQEYKHlYSRHELTPTEDE 646
Cdd:TIGR00840 529 EIRD--------ILGTNLYKPRQRFQS-YSRHVLKPVPLE 559
 
Name Accession Description Interval E-value
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
48-646 0e+00

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 787.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733   48 EWAHVQDPYVIALWILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLLPPIVLDA 127
Cdd:TIGR00840   1 DYEHVQSPYEFILWILLASLAKIGFHLTHKVIRAVPESVLLIVYGLLVGGIIKASPHIDPPTLDSSYFFLYLLPPIVLDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  128 GYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNE 207
Cdd:TIGR00840  81 GYFMPQRNFFENLGSILIFAVVGTLINAFVIGLSLYGICLIGGFGSIDIGLLDNLLFGSLISAVDPVAVLAVFEEYHVNE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  208 VLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEP 287
Cdd:TIGR00840 161 KLYIIIFGESLLNDAVTVVLYNTFIKFHKTADEPVTIVDVFEGCASFFVVTCGGLLVGVVFGFLVAFITRFTHHIRQIEP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  288 GFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVNPF-IWTW 366
Cdd:TIGR00840 241 LFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLSSLSETLIFIFLGVSLVTENhEWNW 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  367 ntAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVF 446
Cdd:TIGR00840 321 --AFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPYKFLFVTTTLVVVF 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  447 FTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQK 526
Cdd:TIGR00840 399 FTVIFQGGTIKPLVEVLKVKKGCISKTKINEELHDREFDHLLPGIEDICGQIGHDRAIDKLNGFDIKYLLKPLIRRNSPK 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  527 SRDrILNVFHELNLKDAISYVAEgerrGSLAFIRSPstdnvvnvdftPRSSTVEASvsyllrenvsavcLDMQSLEQrRR 606
Cdd:TIGR00840 479 SSD-IVAVYHKLNLKQAISLVEG----GSLSFVGTN-----------PEPSNSEPI-------------IPALSSED-KE 528
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 194239733  607 SIRDaedmvthhTLQQYLYKPRQEYKHlYSRHELTPTEDE 646
Cdd:TIGR00840 529 EIRD--------ILGTNLYKPRQRFQS-YSRHVLKPVPLE 559
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
105-462 7.50e-83

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 270.28  E-value: 7.50e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  105 IASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLsglmgdlQIGLLDFLLF 184
Cdd:pfam00999  41 ISEVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILLLALLGVLIPFVLIGLLLYLLGL-------GIPLLEALLF 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  185 GSLMAAVDPVAVLAVF-EEVHVNEVLFIIVFGESLLNDAVTVVLYNVFesfVALGGDNVTGVDCVKGIVSFFVVSLGGTL 263
Cdd:pfam00999 114 GAILSATSPVVVLAILkELGRVPERLGTLLLGESVLNDGVAVVLLAVL---LALAQGVGGGSDLGWLLLIFLVVAVGGLL 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  264 VGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKAN-ISEQSattvRYTMKML 342
Cdd:pfam00999 191 LGLLIGWLLRLITRFTDDDRELEVLLVLLLALLAALLAEALGVSGILGAFLAGLVLSEYPFANkLSEKL----EPFGYGL 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  343 assAETIIFMFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLnryrmvQLEPIDQVVLSYGGL-RGAVAFA 421
Cdd:pfam00999 267 ---FNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRLL------GLSLREALIIGFGGLqRGAVSLA 337
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 194239733  422 LVVLLDGDKVKEKNLFvSTTIIVVFFTVIFQGLTIKPLVQW 462
Cdd:pfam00999 338 LAAIGPLLGIIARELY-PLLIVVVLFTVLVQGITLKPLLFK 377
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
114-553 5.41e-56

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 200.96  E-value: 5.41e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 114 VFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFlsglmgdlQIGLLDFLLFGSLMAAVDP 193
Cdd:COG0025   56 PLLELFLPPLLFEAALNLDLRELRRNGRPILRLAVVGVLLTTLAVALAAHWLL--------GLPLAAALLLGAILAPTDP 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 194 VAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVdcvkgIVSFFVVSLGGTLVGVVFAFLLS 273
Cdd:COG0025  128 VAVSPILRRLGVPKRLRTILEGESLLNDATALVLFVLALAAALGGGFSLGEA-----LLDFLLAILGGILVGLLLGWLLG 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 274 LVTRFTKHVRiIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMF 353
Cdd:COG0025  203 RLLRRLPDPL-LEILLTLALPFLAYLLAEALHGSGVLAVVVAGLVLGNAGRRSLSPETRLQLLEFWETLEFLLNSLLFVL 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 354 LGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRyrmvQLEPIDQVVLSYGGLRGAVAFALVVLL---DGDK 430
Cdd:COG0025  282 LGAQLPLILLGALGLGGILLVLLALLVVRPLWVFLSLALRGS----RLSWRERLFLSWGGPRGIVSLALALSLplhGGAG 357
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 431 VKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAfdHILSAIEDISGQIGHNYLRDKWSHF 510
Cdd:COG0025  358 FPGRDLILALAFGVILLTLVLQGLTLPPLARRLGLREDEPEGEELEAALARAA--LLELLAAELLADDEEVVLRAARRAR 435
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 194239733 511 DRKFLSRVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERR 553
Cdd:COG0025  436 RRREAAELLSEEAEEELDEDLLRLLLALLRLRLLNALAAARLE 478
PRK05326 PRK05326
potassium/proton antiporter;
143-465 7.88e-13

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 71.77  E-value: 7.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 143 ILLYAVVGTVWN----AATTGLSL--YGVFLS-GLMGDLQIGLLDF-----LLFGSLMAAVDPVAVLAVFEEVHVN---- 206
Cdd:PRK05326  70 ILFDGGLRTRWSsfrpALGPALSLatLGVLITaGLTGLFAHWLLGLdwlegLLLGAIVGSTDAAAVFSLLRGKGLNlker 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 207 -----EVlfiivfgESLLNDAVTVVLYNVFESFVAlGGDNVTGVDCVKGIVSFFVVslgGTLVGVVFAFLLSLVTRftkH 281
Cdd:PRK05326 150 vastlEI-------ESGSNDPMAVFLTITLIELIT-GGETGLSWGFLLLFLQQFGL---GALIGLLGGWLLVQLLN---R 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 282 VRIIEPGF--VFIIS--YLSYLTSEMLSLSAILAITFCGIccqkyVKANISEQSATTVRYTMKMLASSAETIIFMFLGIs 357
Cdd:PRK05326 216 IALPAEGLypILVLAgaLLIFALTAALGGSGFLAVYLAGL-----VLGNRPIRHRHSILRFFDGLAWLAQIGMFLVLGL- 289
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 358 AVNP--FIWTWNTAFVL-LTLVFISvyRAIGVVLqtwLLNRYRMVQLEpidQVVLSYGGLRGAVA--FALVVLLDGdkVK 432
Cdd:PRK05326 290 LVTPsrLLDIALPALLLaLFLILVA--RPLAVFL---SLLPFRFNLRE---KLFISWVGLRGAVPivLATFPMMAG--LP 359
                        330       340       350
                 ....*....|....*....|....*....|...
gi 194239733 433 EKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKV 465
Cdd:PRK05326 360 NAQLIFNVVFFVVLVSLLLQGTTLPWAARKLGV 392
 
Name Accession Description Interval E-value
b_cpa1 TIGR00840
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ...
48-646 0e+00

sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273294 [Multi-domain]  Cd Length: 559  Bit Score: 787.43  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733   48 EWAHVQDPYVIALWILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLLPPIVLDA 127
Cdd:TIGR00840   1 DYEHVQSPYEFILWILLASLAKIGFHLTHKVIRAVPESVLLIVYGLLVGGIIKASPHIDPPTLDSSYFFLYLLPPIVLDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  128 GYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNE 207
Cdd:TIGR00840  81 GYFMPQRNFFENLGSILIFAVVGTLINAFVIGLSLYGICLIGGFGSIDIGLLDNLLFGSLISAVDPVAVLAVFEEYHVNE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  208 VLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEP 287
Cdd:TIGR00840 161 KLYIIIFGESLLNDAVTVVLYNTFIKFHKTADEPVTIVDVFEGCASFFVVTCGGLLVGVVFGFLVAFITRFTHHIRQIEP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  288 GFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVNPF-IWTW 366
Cdd:TIGR00840 241 LFVFLISYLSYLFAETLHLSGILALIFCGITMKKYVEANMSRRSQTTIKYFMKMLSSLSETLIFIFLGVSLVTENhEWNW 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  367 ntAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVF 446
Cdd:TIGR00840 321 --AFVVATLSFCVIYRVLGVRTLSWITNEFRPVEIPYKDQLVIFYAGLRGAVAFALALLLDEKIFPYKFLFVTTTLVVVF 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  447 FTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQK 526
Cdd:TIGR00840 399 FTVIFQGGTIKPLVEVLKVKKGCISKTKINEELHDREFDHLLPGIEDICGQIGHDRAIDKLNGFDIKYLLKPLIRRNSPK 478
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  527 SRDrILNVFHELNLKDAISYVAEgerrGSLAFIRSPstdnvvnvdftPRSSTVEASvsyllrenvsavcLDMQSLEQrRR 606
Cdd:TIGR00840 479 SSD-IVAVYHKLNLKQAISLVEG----GSLSFVGTN-----------PEPSNSEPI-------------IPALSSED-KE 528
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 194239733  607 SIRDaedmvthhTLQQYLYKPRQEYKHlYSRHELTPTEDE 646
Cdd:TIGR00840 529 EIRD--------ILGTNLYKPRQRFQS-YSRHVLKPVPLE 559
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
105-462 7.50e-83

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 270.28  E-value: 7.50e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  105 IASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLsglmgdlQIGLLDFLLF 184
Cdd:pfam00999  41 ISEVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILLLALLGVLIPFVLIGLLLYLLGL-------GIPLLEALLF 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  185 GSLMAAVDPVAVLAVF-EEVHVNEVLFIIVFGESLLNDAVTVVLYNVFesfVALGGDNVTGVDCVKGIVSFFVVSLGGTL 263
Cdd:pfam00999 114 GAILSATSPVVVLAILkELGRVPERLGTLLLGESVLNDGVAVVLLAVL---LALAQGVGGGSDLGWLLLIFLVVAVGGLL 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  264 VGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKAN-ISEQSattvRYTMKML 342
Cdd:pfam00999 191 LGLLIGWLLRLITRFTDDDRELEVLLVLLLALLAALLAEALGVSGILGAFLAGLVLSEYPFANkLSEKL----EPFGYGL 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  343 assAETIIFMFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLnryrmvQLEPIDQVVLSYGGL-RGAVAFA 421
Cdd:pfam00999 267 ---FNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRLL------GLSLREALIIGFGGLqRGAVSLA 337
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 194239733  422 LVVLLDGDKVKEKNLFvSTTIIVVFFTVIFQGLTIKPLVQW 462
Cdd:pfam00999 338 LAAIGPLLGIIARELY-PLLIVVVLFTVLVQGITLKPLLFK 377
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
114-553 5.41e-56

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 200.96  E-value: 5.41e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 114 VFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFlsglmgdlQIGLLDFLLFGSLMAAVDP 193
Cdd:COG0025   56 PLLELFLPPLLFEAALNLDLRELRRNGRPILRLAVVGVLLTTLAVALAAHWLL--------GLPLAAALLLGAILAPTDP 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 194 VAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVdcvkgIVSFFVVSLGGTLVGVVFAFLLS 273
Cdd:COG0025  128 VAVSPILRRLGVPKRLRTILEGESLLNDATALVLFVLALAAALGGGFSLGEA-----LLDFLLAILGGILVGLLLGWLLG 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 274 LVTRFTKHVRiIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMF 353
Cdd:COG0025  203 RLLRRLPDPL-LEILLTLALPFLAYLLAEALHGSGVLAVVVAGLVLGNAGRRSLSPETRLQLLEFWETLEFLLNSLLFVL 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 354 LGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRyrmvQLEPIDQVVLSYGGLRGAVAFALVVLL---DGDK 430
Cdd:COG0025  282 LGAQLPLILLGALGLGGILLVLLALLVVRPLWVFLSLALRGS----RLSWRERLFLSWGGPRGIVSLALALSLplhGGAG 357
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 431 VKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAfdHILSAIEDISGQIGHNYLRDKWSHF 510
Cdd:COG0025  358 FPGRDLILALAFGVILLTLVLQGLTLPPLARRLGLREDEPEGEELEAALARAA--LLELLAAELLADDEEVVLRAARRAR 435
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 194239733 511 DRKFLSRVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERR 553
Cdd:COG0025  436 RRREAAELLSEEAEEELDEDLLRLLLALLRLRLLNALAAARLE 478
a_cpa1 TIGR00831
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ...
110-552 9.80e-32

Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129911 [Multi-domain]  Cd Length: 525  Bit Score: 130.78  E-value: 9.80e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  110 LTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVflsglmgdLQIGLLDFLLFGSLMA 189
Cdd:TIGR00831  46 LDREIVLFLFLPPLLFEAAMNTDLRELRENFRPIALIAFLLVVVTTVVVGFSLNWI--------LGIPLALALILGAVLS 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  190 AVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYnVFESFVALGgdnVTGVDCVKGIVSFFVVSLGGTLVGVVFA 269
Cdd:TIGR00831 118 PTDAVAVLGTFKSIRAPKKLSILLEGESLLNDGAALVVF-AIAVAVALG---KGVFDPLNAALDFAVVCVGGIAAGLAVG 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  270 FLLSLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKY-VKANISEQSATTVRYTMKMLASSAET 348
Cdd:TIGR00831 194 YLAYRLLRAKIDDPLVEIALTILAPFAGFLLAERFHFSGVIAVVAAGLILTNYgRDFSMSPTTRLIALDFWSVIVFLVNG 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  349 IIFMFLGISAVNPFIWTWNTAFVL-------LTLVFISVYRAIGVVLQTWLLNRY--RMVQLEPID-----QVVLSYGGL 414
Cdd:TIGR00831 274 IIFILIGVQTPGTIFSAWKEILVApaavilaLFTNAFVIYPVMTYVRFLWTMKPFsnRFLKKKPMEfgtrwKHVVSWAGL 353
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  415 RGAVAFALVV-----LLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVkrSEHREpRLNEKLHGR------A 483
Cdd:TIGR00831 354 RGAIPLALALsfpnqLLSGMAFPARYELVFLAAGVILFSLLVQGISLPIFVKRKFV--SEHSE-RELEEIIARyiaarsA 430
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  484 FDHILSAIEDisGQIGHNYLRdkwsHFDRKFLSRVLMRRSaqKSRDRILNVFHELNL-KDAISYVAEGER 552
Cdd:TIGR00831 431 KFALMKAVEQ--LRIVEPVAR----ELLPELDARIEELRA--DGEEKIRSGMGEKNLrRRARLYVLDAKR 492
NhaP2 COG3263
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ...
135-474 8.28e-16

NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 442494 [Multi-domain]  Cd Length: 502  Bit Score: 81.31  E-value: 8.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 135 LFFGNLGT------------ILLyAVVGTVWNAATTGLSLYGVflsglmgdLQIGLLDFLLFGSLMAAVDPVAVLAVF-- 200
Cdd:COG3263   71 LFDGGLRTrwssfrpvlapaLSL-ATLGVLLTAGLTGVFAHWL--------LGLSWLEGLLLGAIVSSTDAAAVFSILrs 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 201 EEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGvdcvkgIVSFFVVSLG-GTLVGVVFAFLLSLVTRft 279
Cdd:COG3263  142 KGLNLKERLASTLELESGSNDPMAVFLTIALIELITGGGASGWS------LLLLFVLQMGlGALVGLAGGWLGVWLLN-- 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 280 kHVRIIEPGF--VFIISY--LSYLTSEMLSLSAILAITFCGIccqkyVKANISEQSATTVRYTMKMLASSAETIIFMFLG 355
Cdd:COG3263  214 -RIRLPAEGLypVLVLALalLAFGATALLGGSGFLAVYLAGL-----VLGNRRLPHKKSILRFHDGLAWLAQIGMFLMLG 287
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 356 ISaVNP--FIWTWNTAFVL-LTLVFISvyRAIGVVLQTWLLnRYRMVQlepidQVVLSYGGLRGAVA--FALVVLLDGdk 430
Cdd:COG3263  288 LL-VFPsrLLPVALPALLIaLFLIFVA--RPLAVFLSLLPF-RFSWRE-----KLFISWVGLRGAVPivLATFPLLAG-- 356
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 194239733 431 VKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPR 474
Cdd:COG3263  357 LPGAQLIFNVVFFVVLVSLLVQGTTLPPVARKLGLEVPPEPKPL 400
PRK05326 PRK05326
potassium/proton antiporter;
143-465 7.88e-13

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 71.77  E-value: 7.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 143 ILLYAVVGTVWN----AATTGLSL--YGVFLS-GLMGDLQIGLLDF-----LLFGSLMAAVDPVAVLAVFEEVHVN---- 206
Cdd:PRK05326  70 ILFDGGLRTRWSsfrpALGPALSLatLGVLITaGLTGLFAHWLLGLdwlegLLLGAIVGSTDAAAVFSLLRGKGLNlker 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 207 -----EVlfiivfgESLLNDAVTVVLYNVFESFVAlGGDNVTGVDCVKGIVSFFVVslgGTLVGVVFAFLLSLVTRftkH 281
Cdd:PRK05326 150 vastlEI-------ESGSNDPMAVFLTITLIELIT-GGETGLSWGFLLLFLQQFGL---GALIGLLGGWLLVQLLN---R 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 282 VRIIEPGF--VFIIS--YLSYLTSEMLSLSAILAITFCGIccqkyVKANISEQSATTVRYTMKMLASSAETIIFMFLGIs 357
Cdd:PRK05326 216 IALPAEGLypILVLAgaLLIFALTAALGGSGFLAVYLAGL-----VLGNRPIRHRHSILRFFDGLAWLAQIGMFLVLGL- 289
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733 358 AVNP--FIWTWNTAFVL-LTLVFISvyRAIGVVLqtwLLNRYRMVQLEpidQVVLSYGGLRGAVA--FALVVLLDGdkVK 432
Cdd:PRK05326 290 LVTPsrLLDIALPALLLaLFLILVA--RPLAVFL---SLLPFRFNLRE---KLFISWVGLRGAVPivLATFPMMAG--LP 359
                        330       340       350
                 ....*....|....*....|....*....|...
gi 194239733 433 EKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKV 465
Cdd:PRK05326 360 NAQLIFNVVFFVVLVSLLLQGTTLPWAARKLGV 392
NEXCaM_BD pfam16644
Regulatory region of Na+/H+ exchanger NHE binds to calmodulin; NEXCaM_BD is a coiled-coil ...
604-668 2.02e-03

Regulatory region of Na+/H+ exchanger NHE binds to calmodulin; NEXCaM_BD is a coiled-coil domain found as part of the regulatory, C-terminal region of the 12-14 TM sodium/proton exchangers (NHEs)2 of the solute carrier 9 (SLC9) family in all animal kingdoms. The C- lobe of CaM binds the first alpha-helix of the NHE, or NEXCaM_BD region, and the N-lobe of CaM binds the second helix of NEXCaM_BD.


Pssm-ID: 465214  Cd Length: 109  Bit Score: 38.54  E-value: 2.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194239733  604 RRRSIRDAEDMvtHHTLQQYLYKPRQEYKHlYSRHELTPTEDEKQDREIF---HRTMR--KRLESFKSTK 668
Cdd:pfam16644  17 KRLSPADVEEM--RDILSKNLYQIRQRTLS-YNRHNLVADTSEKQAKEILirrQHSLResLRKGSSLPGR 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH