NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4757956|ref|NP_004053|]
View 

cadherin-16 isoform 1 precursor [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10638917)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 342-445 1.71e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.71e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956  342 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 420
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*
gi 4757956  421 DlaGAEGGFSSTCEVEVAVTDINDH 445
Cdd:cd11304  76 D--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 264-332 2.35e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.35e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4757956  264 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 332
Cdd:cd11304  28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 47-124 2.64e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 2.64e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4757956      47 PREGAEGQIVLSGDSGkATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVP 124
Cdd:smart00112   5 ADSGENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 568-655 8.97e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 8.97e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956  568 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQDTDE 643
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                        90
                ....*....|..
gi 4757956  644 PRLSASAPLVIH 655
Cdd:cd11304  80 PPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 130-234 5.82e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 5.82e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956  130 IYRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQL 209
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                        90       100
                ....*....|....*....|....*
gi 4757956  210 LVQVKDMGDQAsgHQATATVEVSII 234
Cdd:cd11304  71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 457-558 6.64e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 6.64e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956  457 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 536
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                        90       100
                ....*....|....*....|....*..
gi 4757956  537 kLV-----GPGPGPGATATVTVLVERV 558
Cdd:cd11304  70 -LTvtatdGGGPPLSSTATVTITVLDV 95
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 342-445 1.71e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.71e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956  342 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 420
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*
gi 4757956  421 DlaGAEGGFSSTCEVEVAVTDINDH 445
Cdd:cd11304  76 D--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 264-332 2.35e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.35e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4757956  264 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 332
Cdd:cd11304  28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 264-334 1.95e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 1.95e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4757956     264 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVP 334
Cdd:smart00112   9 ENGKVTYSILSgNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 47-124 2.64e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 2.64e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4757956      47 PREGAEGQIVLSGDSGkATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVP 124
Cdd:smart00112   5 ADSGENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 568-655 8.97e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 8.97e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956  568 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQDTDE 643
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                        90
                ....*....|..
gi 4757956  644 PRLSASAPLVIH 655
Cdd:cd11304  80 PPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 359-447 1.54e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.60  E-value: 1.54e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956     359 SAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTLgVLPL--RAGQNILLLVLAMDlaGAEGGFSSTCEVE 436
Cdd:smart00112   1 SATDADSG--ENGKVTYSILS-----GNDDGLFSIDPETGEITT-TKPLdrEEQPEYTLTVEATD--GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 4757956     437 VAVTDINDHAP 447
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-121 3.06e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 3.06e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4757956   49 EGAEGQIV--LSGDSGkatEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEND 121
Cdd:cd11304  26 SGENGEVTysIVSGNE---DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 130-234 5.82e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 5.82e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956  130 IYRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQL 209
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                        90       100
                ....*....|....*....|....*
gi 4757956  210 LVQVKDMGDQAsgHQATATVEVSII 234
Cdd:cd11304  71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 457-558 6.64e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 6.64e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956  457 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 536
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                        90       100
                ....*....|....*....|....*..
gi 4757956  537 kLV-----GPGPGPGATATVTVLVERV 558
Cdd:cd11304  70 -LTvtatdGGGPPLSSTATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
341-440 1.55e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956    341 PTVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSPEPedgveGRAFQVDPTSGSVTLGVlPLR--AGQNILLLVL 418
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP-----GGNFRIDPDTGDISTTK-PLDreSIGEYELTVE 72

                          90       100
                  ....*....|....*....|..
gi 4757956    419 AMDLAGaeGGFSSTCEVEVAVT 440
Cdd:pfam00028  73 ATDSGG--PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
456-556 1.98e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 1.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956    456 PISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEVvvvvqSV 535
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRID--PDTGDISTT--KPLDRESIGEYEL-----TV 71

                          90       100
                  ....*....|....*....|.
gi 4757956    536 AKLVGPGPGPGATATVTVLVE 556
Cdd:pfam00028  72 EATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 150-234 1.34e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.66  E-value: 1.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956     150 ASDRDEPgtANSDLRFHILSQAPaqpsPDMFQLEPRLGALALSpkgsTSLDHALERTYQLLVQVKDMGDQAsgHQATATV 229
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGND----DGLFSIDPETGEITTT----KPLDREEQPEYTLTVEATDGGGPP--LSSTATV 69


                   ....*
gi 4757956     230 EVSII 234
Cdd:smart00112  70 TITVL 74
Cadherin pfam00028
Cadherin domain;
26-116 1.66e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.61  E-value: 1.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956     26 SVEVPENY-GGNFPLYLTKLPlPREGAEGQIV---LSGDSGkateGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQ 101
Cdd:pfam00028   2 SASVPENApVGTEVLTVTATD-PDLGPNGRIFysiLGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 4757956    102 DGHVLWGPQPVLVHV 116
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
272-326 9.06e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 9.06e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4757956    272 LESHPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLV 326
Cdd:pfam00028  36 LGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
131-234 2.93e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.44  E-value: 2.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956    131 YRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQLL 210
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDISTT----KPLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|....
gi 4757956    211 VQVKDMGDQASghQATATVEVSII 234
Cdd:pfam00028  71 VEATDSGGPPL--SSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 342-445 1.71e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.68  E-value: 1.71e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956  342 TVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTL-GVLPLRAGQNILLLVLAM 420
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVS-----GNEDGLFSIDPSTGEITTaKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*
gi 4757956  421 DlaGAEGGFSSTCEVEVAVTDINDH 445
Cdd:cd11304  76 D--GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 264-332 2.35e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.35e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4757956  264 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 332
Cdd:cd11304  28 ENGEVTYSIVSgNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 264-334 1.95e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 1.95e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4757956     264 SGGDVHYHLES-HPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDNVP 334
Cdd:smart00112   9 ENGKVTYSILSgNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 47-124 2.64e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 2.64e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4757956      47 PREGAEGQIVLSGDSGkATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVP 124
Cdd:smart00112   5 ADSGENGKVTYSILSG-NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 568-655 8.97e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 8.97e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956  568 SYEASVPISAPAGSFLLTIQPSDP---ISRTLRFSLVNDSE-GWLCIEKFSGEVHTAQSLQGAQPgDTYTVLVEAQDTDE 643
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREEQ-SSYTLTVTATDGGG 79

                        90
                ....*....|..
gi 4757956  644 PRLSASAPLVIH 655
Cdd:cd11304  80 PPLSSTATVTIT 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 359-447 1.54e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.60  E-value: 1.54e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956     359 SAEDADAPgsPNSHVVYQLLSpepedGVEGRAFQVDPTSGSVTLgVLPL--RAGQNILLLVLAMDlaGAEGGFSSTCEVE 436
Cdd:smart00112   1 SATDADSG--ENGKVTYSILS-----GNDDGLFSIDPETGEITT-TKPLdrEEQPEYTLTVEATD--GGGPPLSSTATVT 70

                           90
                   ....*....|.
gi 4757956     437 VAVTDINDHAP 447
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 49-121 3.06e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 66.18  E-value: 3.06e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4757956   49 EGAEGQIV--LSGDSGkatEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDEND 121
Cdd:cd11304  26 SGENGEVTysIVSGNE---DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 130-234 5.82e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 5.82e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956  130 IYRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQL 209
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVSG----NEDGLFSIDPSTGEITTA----KPLDREEQSSYTL 70

                        90       100
                ....*....|....*....|....*
gi 4757956  210 LVQVKDMGDQAsgHQATATVEVSII 234
Cdd:cd11304  71 TVTATDGGGPP--LSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 457-558 6.64e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 62.33  E-value: 6.64e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956  457 ISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEvvvvvqsva 536
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVT-YSIVSGNEDGLFSID--PSTGEITTA--KPLDREEQSSYT--------- 69

                        90       100
                ....*....|....*....|....*..
gi 4757956  537 kLV-----GPGPGPGATATVTVLVERV 558
Cdd:cd11304  70 -LTvtatdGGGPPLSSTATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
341-440 1.55e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 1.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956    341 PTVSIPELSPPGTEVTRLSAEDADAPgsPNSHVVYQLLSPEPedgveGRAFQVDPTSGSVTLGVlPLR--AGQNILLLVL 418
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGP-----GGNFRIDPDTGDISTTK-PLDreSIGEYELTVE 72

                          90       100
                  ....*....|....*....|..
gi 4757956    419 AMDLAGaeGGFSSTCEVEVAVT 440
Cdd:pfam00028  73 ATDSGG--PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
456-556 1.98e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 1.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956    456 PISLPEDVEPGTLVAMLTAIDADLEPAFRLMdFAIERGDTEGTFGLDwePDSGHVRLRlcKNLSYEAAPSHEVvvvvqSV 535
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRID--PDTGDISTT--KPLDRESIGEYEL-----TV 71

                          90       100
                  ....*....|....*....|.
gi 4757956    536 AKLVGPGPGPGATATVTVLVE 556
Cdd:pfam00028  72 EATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 150-234 1.34e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.66  E-value: 1.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956     150 ASDRDEPgtANSDLRFHILSQAPaqpsPDMFQLEPRLGALALSpkgsTSLDHALERTYQLLVQVKDMGDQAsgHQATATV 229
Cdd:smart00112   2 ATDADSG--ENGKVTYSILSGND----DGLFSIDPETGEITTT----KPLDREEQPEYTLTVEATDGGGPP--LSSTATV 69


                   ....*
gi 4757956     230 EVSII 234
Cdd:smart00112  70 TITVL 74
Cadherin pfam00028
Cadherin domain;
26-116 1.66e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.61  E-value: 1.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956     26 SVEVPENY-GGNFPLYLTKLPlPREGAEGQIV---LSGDSGkateGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQ 101
Cdd:pfam00028   2 SASVPENApVGTEVLTVTATD-PDLGPNGRIFysiLGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 4757956    102 DGHVLWGPQPVLVHV 116
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
272-326 9.06e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 9.06e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4757956    272 LESHPPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLV 326
Cdd:pfam00028  36 LGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 29-121 2.30e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.87  E-value: 2.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956   29 VPENYGGnfPLYLTKLPLPREGAEGQIV-LSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLW 107
Cdd:cd00031   6 AVEGRSR--GSFRVSIPTDLIASSGEIIkISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQ 83

                        90
                ....*....|....
gi 4757956  108 GPQPVLVHVKDEND 121
Cdd:cd00031  84 TSSVFSIEVYDEND 97
Cadherin pfam00028
Cadherin domain;
131-234 2.93e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.44  E-value: 2.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757956    131 YRARLSRGTRPGIPFLFLEASDRDEPgtANSDLRFHILSQapaqPSPDMFQLEPRLGALALSpkgsTSLDHALERTYQLL 210
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGDISTT----KPLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|....
gi 4757956    211 VQVKDMGDQASghQATATVEVSII 234
Cdd:pfam00028  71 VEATDSGGPPL--SSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 276-332 8.66e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 42.33  E-value: 8.66e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4757956  276 PPGPFEVNAE-GNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPLELHVLVMDENDN 332
Cdd:cd00031  41 LPSWLHWEPHsGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH