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Conserved domains on  [gi|4504079|ref|NP_003792|]
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glycosylphosphatidylinositol anchor attachment 1 protein [Homo sapiens]

Protein Classification

glycosylphosphatidylinositol anchor attachment 1 protein( domain architecture ID 10513790)

glycosylphosphatidylinositol anchor attachment 1 protein (GPI anchor attachment protein 1 or GAA1 protein homolog) is essential for GPI-anchoring of precursor proteins but not for GPI synthesis; it acts before or during formation of the carbonyl intermediate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Gaa1 pfam04114
Gaa1-like, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase is a ...
125-615 0e+00

Gaa1-like, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex. Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase that adds glycosylphosphatidylinositols (GPIs) to newly synthesized proteins.


:

Pssm-ID: 461181  Cd Length: 496  Bit Score: 532.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    125 SGTNVYGILRAPRAASTESLVLTVPC-GSDST-NSQAVGLLLALAAHFRGQIYWAKDIVFLVTEHDLLGTEAWLEAYHDV 202
Cdd:pfam04114   1 KGENVYGILRAPRGDSTEAIVLVAPWrTSDGElNLGGVALALALARYFKRQSYWAKDIIFLVTEDEQLGMQAWLEAYHDT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    203 NVTGMQSSPLQGRAGAIQAAVALEL--SSDVVTSLDVAVEGLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPEDwtSL 280
Cdd:pfam04114  81 HTTGLDAGSLPGRAGAIQAALVLEYpsSSDNFDSLDIKYEGLNGQLPNLDLFNTAVSIAQKEGIKCTLQGMLDHQD--SP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    281 DGPLQGLQTLLLMVLRQASGRPHGSHGLFLRYRVEALTLRGINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQSFFLY 360
Cdd:pfam04114 159 NSYESRLQTLLRGMLTQALGVPTGNHGLFHRYHIDAITLRGKGRGRSGWYDETQLGRIIEGIFRSLNNLLERFHQSFFFY 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    361 LLPGLSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEAGMGLEEpgGAPGPSVPLPPSQGVGLASLVAPLLISQAMGLA 440
Cdd:pfam04114 239 LLPSTNRFVSIGTYMPSAGLLAGSFTIKALALWLELSGSQASSES--GKSLEEEGEPGSLERGLLLVLTVVLVSHLLGYL 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    441 LYVLPVLGQHVAtQHFPVAEAEAVVLTLLAIYAAGLALPHNTHRVVSTQAPDRGWMALKLVALIYLALQLGCIALTNFSL 520
Cdd:pfam04114 317 LYLLPTKLTQLA-GHFPLSTQDSLSLGLIAISVLGLILPLFLSPFLKRPSTPQQWELLKSFSLLYLGLFLSCLALLNFSL 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    521 GFLLATTMVPTAALAKP------HGPRTLYAALLVLTSPAATLLG-SLFLWRELQEAPLsLAEGWQLFLAALAQGVLEHH 593
Cdd:pfam04114 396 AFLVALLAVPLTFIARPtaessrRLLRILRSLLLLLLSPLVVLYLvLLYLFPELEELPL-LYRSWQAALQALTQAAFDWV 474
                         490       500
                  ....*....|....*....|..
gi 4504079    594 TYGALLFPLLSLGLYPCWLLFW 615
Cdd:pfam04114 475 IYGSWTFFVVWLVWWPAWLLGW 496
 
Name Accession Description Interval E-value
Gaa1 pfam04114
Gaa1-like, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase is a ...
125-615 0e+00

Gaa1-like, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex. Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase that adds glycosylphosphatidylinositols (GPIs) to newly synthesized proteins.


Pssm-ID: 461181  Cd Length: 496  Bit Score: 532.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    125 SGTNVYGILRAPRAASTESLVLTVPC-GSDST-NSQAVGLLLALAAHFRGQIYWAKDIVFLVTEHDLLGTEAWLEAYHDV 202
Cdd:pfam04114   1 KGENVYGILRAPRGDSTEAIVLVAPWrTSDGElNLGGVALALALARYFKRQSYWAKDIIFLVTEDEQLGMQAWLEAYHDT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    203 NVTGMQSSPLQGRAGAIQAAVALEL--SSDVVTSLDVAVEGLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPEDwtSL 280
Cdd:pfam04114  81 HTTGLDAGSLPGRAGAIQAALVLEYpsSSDNFDSLDIKYEGLNGQLPNLDLFNTAVSIAQKEGIKCTLQGMLDHQD--SP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    281 DGPLQGLQTLLLMVLRQASGRPHGSHGLFLRYRVEALTLRGINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQSFFLY 360
Cdd:pfam04114 159 NSYESRLQTLLRGMLTQALGVPTGNHGLFHRYHIDAITLRGKGRGRSGWYDETQLGRIIEGIFRSLNNLLERFHQSFFFY 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    361 LLPGLSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEAGMGLEEpgGAPGPSVPLPPSQGVGLASLVAPLLISQAMGLA 440
Cdd:pfam04114 239 LLPSTNRFVSIGTYMPSAGLLAGSFTIKALALWLELSGSQASSES--GKSLEEEGEPGSLERGLLLVLTVVLVSHLLGYL 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    441 LYVLPVLGQHVAtQHFPVAEAEAVVLTLLAIYAAGLALPHNTHRVVSTQAPDRGWMALKLVALIYLALQLGCIALTNFSL 520
Cdd:pfam04114 317 LYLLPTKLTQLA-GHFPLSTQDSLSLGLIAISVLGLILPLFLSPFLKRPSTPQQWELLKSFSLLYLGLFLSCLALLNFSL 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    521 GFLLATTMVPTAALAKP------HGPRTLYAALLVLTSPAATLLG-SLFLWRELQEAPLsLAEGWQLFLAALAQGVLEHH 593
Cdd:pfam04114 396 AFLVALLAVPLTFIARPtaessrRLLRILRSLLLLLLSPLVVLYLvLLYLFPELEELPL-LYRSWQAALQALTQAAFDWV 474
                         490       500
                  ....*....|....*....|..
gi 4504079    594 TYGALLFPLLSLGLYPCWLLFW 615
Cdd:pfam04114 475 IYGSWTFFVVWLVWWPAWLLGW 496
 
Name Accession Description Interval E-value
Gaa1 pfam04114
Gaa1-like, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase is a ...
125-615 0e+00

Gaa1-like, GPI transamidase component; GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex. Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase that adds glycosylphosphatidylinositols (GPIs) to newly synthesized proteins.


Pssm-ID: 461181  Cd Length: 496  Bit Score: 532.23  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    125 SGTNVYGILRAPRAASTESLVLTVPC-GSDST-NSQAVGLLLALAAHFRGQIYWAKDIVFLVTEHDLLGTEAWLEAYHDV 202
Cdd:pfam04114   1 KGENVYGILRAPRGDSTEAIVLVAPWrTSDGElNLGGVALALALARYFKRQSYWAKDIIFLVTEDEQLGMQAWLEAYHDT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    203 NVTGMQSSPLQGRAGAIQAAVALEL--SSDVVTSLDVAVEGLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPEDwtSL 280
Cdd:pfam04114  81 HTTGLDAGSLPGRAGAIQAALVLEYpsSSDNFDSLDIKYEGLNGQLPNLDLFNTAVSIAQKEGIKCTLQGMLDHQD--SP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    281 DGPLQGLQTLLLMVLRQASGRPHGSHGLFLRYRVEALTLRGINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQSFFLY 360
Cdd:pfam04114 159 NSYESRLQTLLRGMLTQALGVPTGNHGLFHRYHIDAITLRGKGRGRSGWYDETQLGRIIEGIFRSLNNLLERFHQSFFFY 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    361 LLPGLSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEAGMGLEEpgGAPGPSVPLPPSQGVGLASLVAPLLISQAMGLA 440
Cdd:pfam04114 239 LLPSTNRFVSIGTYMPSAGLLAGSFTIKALALWLELSGSQASSES--GKSLEEEGEPGSLERGLLLVLTVVLVSHLLGYL 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    441 LYVLPVLGQHVAtQHFPVAEAEAVVLTLLAIYAAGLALPHNTHRVVSTQAPDRGWMALKLVALIYLALQLGCIALTNFSL 520
Cdd:pfam04114 317 LYLLPTKLTQLA-GHFPLSTQDSLSLGLIAISVLGLILPLFLSPFLKRPSTPQQWELLKSFSLLYLGLFLSCLALLNFSL 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504079    521 GFLLATTMVPTAALAKP------HGPRTLYAALLVLTSPAATLLG-SLFLWRELQEAPLsLAEGWQLFLAALAQGVLEHH 593
Cdd:pfam04114 396 AFLVALLAVPLTFIARPtaessrRLLRILRSLLLLLLSPLVVLYLvLLYLFPELEELPL-LYRSWQAALQALTQAAFDWV 474
                         490       500
                  ....*....|....*....|..
gi 4504079    594 TYGALLFPLLSLGLYPCWLLFW 615
Cdd:pfam04114 475 IYGSWTFFVVWLVWWPAWLLGW 496
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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