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Conserved domains on  [gi|29171736|ref|NP_003702|]
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phospholipid phosphatase 1 isoform 1 [Homo sapiens]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0042577|GO:0046839|GO:0008610
PubMed:  9122162|12447906|9260289
SCOP:  3001110|4001226

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 98-243 1.48e-73

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 222.12  E-value: 1.48e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736  98 IYKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCS---DGYIEYYICRGNAERVKEGRLSFYSGHSSF 174
Cdd:cd03384   2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSldhQYIADCTCCTGDPDLIREARLSFPSGHASL 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29171736 175 SMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVA 243
Cdd:cd03384  82 SMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 98-243 1.48e-73

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 222.12  E-value: 1.48e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736  98 IYKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCS---DGYIEYYICRGNAERVKEGRLSFYSGHSSF 174
Cdd:cd03384   2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSldhQYIADCTCCTGDPDLIREARLSFPSGHASL 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29171736 175 SMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVA 243
Cdd:cd03384  82 SMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
acidPPc smart00014
Acid phosphatase homologues;
106-242 6.37e-30

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 108.97  E-value: 6.37e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736    106 LFGAAASQSLTDIAKYSIGRLRPHFLDVCDpdwskincsdgyieyYICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALY 185
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGD---------------ACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 29171736    186 LqarmkgdWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILV 242
Cdd:smart00014  66 L-------PARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVL 115
PLN02715 PLN02715
lipid phosphate phosphatase
 45-239 1.45e-21

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 92.42  E-value: 1.45e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736   45 IKYPYKEDTIPYAllggiiipfsiiviilgeTLSVYCNLLHSNSFI----RNNYIATIYKAIGTFLFGAAASQSLTDIAK 120
Cdd:PLN02715  82 LKYPFKDNTVPIW------------------SVPVYAVLLPIILFVcfylKRRCVYDLHHSILGLLFAVLITGVITDSIK 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736  121 YSIGRLRPHFLDVCDPDWSKINCSDGYIeyyICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALYLQARMK-----GDWA 195
Cdd:PLN02715 144 VATGRPRPNFYWRCFPDGKELYDALGGV---ICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKafngeGHVA 220

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 29171736  196 RLLrpTLQFGLVAVSIyVGLSRVSDYKHHWSDVLTGLIQGALVA 239
Cdd:PLN02715 221 KLC--LVIFPLLAACL-VGISRVDDYWHHWQDVFAGALIGILVA 261
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 105-246 7.60e-21

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 85.55  E-value: 7.60e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736   105 FLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSkincsdgyieyyicrgNAERVKEGRLSFYSGHSSFSMYCMLFVAL 184
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVP----------------APSTLPGLGYSFPSGHSATAFALALLLAL 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29171736   185 YLqarmkGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYV 246
Cdd:pfam01569  66 LL-----RRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 101-246 1.26e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 50.81  E-value: 1.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736 101 AIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDwskINCSDGYieyyicrgnaervkegrlSFYSGHSSFSMYCML 180
Cdd:COG0671  74 LLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELL---LGTAGGY------------------SFPSGHAAAAFALAL 132

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 29171736 181 FVALYLQARmkgdWARLLrptlqfgLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYV 246
Cdd:COG0671 133 VLALLLPRR----WLAAL-------LLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 98-243 1.48e-73

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 222.12  E-value: 1.48e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736  98 IYKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKINCS---DGYIEYYICRGNAERVKEGRLSFYSGHSSF 174
Cdd:cd03384   2 LYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSldhQYIADCTCCTGDPDLIREARLSFPSGHASL 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29171736 175 SMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVA 243
Cdd:cd03384  82 SMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 44-242 7.29e-33

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 119.25  E-value: 7.29e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736  44 SIKYPYKED-TIPYALLGgiiipfsiiVIILGETLSVYCNLlhsnSFIRNNYIATIYKAIGTFLFGAAASQSLTDIAKYS 122
Cdd:cd03390   2 SISYPFAESeTVPTWLLV---------IISVGIPLLVIILI----SLFFRRSLWDLHTSLLGLLLSVSLNGVITNVLKNY 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736 123 IGRLRPHFLDVCDPDwsKINCSDGYIEYYICR-GNAERVKEGRLSFYSGHSSFSMYCMLFVALYLQARMK-----GDWAR 196
Cdd:cd03390  69 AGRPRPDFLARCFPD--GGTPSDTLVGIDICCtGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHifdprGSSWR 146

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 29171736 197 LLrptLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILV 242
Cdd:cd03390 147 LL---LALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLS 189
acidPPc smart00014
Acid phosphatase homologues;
106-242 6.37e-30

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 108.97  E-value: 6.37e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736    106 LFGAAASQSLTDIAKYSIGRLRPHFLDVCDpdwskincsdgyieyYICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALY 185
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGD---------------ACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 29171736    186 LqarmkgdWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILV 242
Cdd:smart00014  66 L-------PARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVL 115
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 99-242 4.06e-25

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 96.76  E-value: 4.06e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736  99 YKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDwskincsdgyieyyicrGNAERVKEGRLSFYSGHSSFSMYC 178
Cdd:cd01610   2 RLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPD-----------------GDPLLLTEGGYSFPSGHAAFAFAL 64

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29171736 179 MLFVALYLqarmkgdWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILV 242
Cdd:cd01610  65 ALFLALLL-------PRRLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLV 121
PLN02715 PLN02715
lipid phosphate phosphatase
 45-239 1.45e-21

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 92.42  E-value: 1.45e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736   45 IKYPYKEDTIPYAllggiiipfsiiviilgeTLSVYCNLLHSNSFI----RNNYIATIYKAIGTFLFGAAASQSLTDIAK 120
Cdd:PLN02715  82 LKYPFKDNTVPIW------------------SVPVYAVLLPIILFVcfylKRRCVYDLHHSILGLLFAVLITGVITDSIK 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736  121 YSIGRLRPHFLDVCDPDWSKINCSDGYIeyyICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALYLQARMK-----GDWA 195
Cdd:PLN02715 144 VATGRPRPNFYWRCFPDGKELYDALGGV---ICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKafngeGHVA 220

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 29171736  196 RLLrpTLQFGLVAVSIyVGLSRVSDYKHHWSDVLTGLIQGALVA 239
Cdd:PLN02715 221 KLC--LVIFPLLAACL-VGISRVDDYWHHWQDVFAGALIGILVA 261
PLN02250 PLN02250
lipid phosphate phosphatase
 89-239 3.29e-21

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 91.14  E-value: 3.29e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736   89 FIRNNyIATIYKAIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSKIncSDGYIEYYICRGNAERVKEGRLSFY 168
Cdd:PLN02250  88 FIRRD-VYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGV--FHPVTTDVLCTGAKSVIKEGHKSFP 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 29171736  169 SGHSSFSMYCMLFVALYLQARM-----KGDWARLlrpTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVA 239
Cdd:PLN02250 165 SGHTSWSFAGLGFLSLYLSGKIrvfdrRGHVAKL---CIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVA 237
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 105-246 7.60e-21

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 85.55  E-value: 7.60e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736   105 FLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDWSkincsdgyieyyicrgNAERVKEGRLSFYSGHSSFSMYCMLFVAL 184
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVP----------------APSTLPGLGYSFPSGHSATAFALALLLAL 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29171736   185 YLqarmkGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYV 246
Cdd:pfam01569  66 LL-----RRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 45-235 4.83e-18

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 82.38  E-value: 4.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736   45 IKYPYKEDTIPYAllggiiipfsiiviilgeTLSVYCNLLHSNSFI----RNNYIATIYKAIGTFLFGAAASQSLTDIAK 120
Cdd:PLN02731  76 LSYPLKSNTVPIW------------------SVPVYAMLLPLVIFIfiyfRRRDVYDLHHAVLGLLYSVLVTAVLTDAIK 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736  121 YSIGRLRPHFLDVCDPDWSKINCSDGYIeyyICRGNAERVKEGRLSFYSGHSSFSMYCMLFVALYLQARM-----KGDWA 195
Cdd:PLN02731 138 NAVGRPRPDFFWRCFPDGKALYDSLGDV---ICHGDKSVIREGHKSFPSGHTSWSFSGLGFLSLYLSGKIqafdgKGHVA 214

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 29171736  196 RLLRPTLQFGLVAVsiyVGLSRVSDYKHHWSDVLTGLIQG 235
Cdd:PLN02731 215 KLCIVILPLLFAAL---VGISRVDDYWHHWQDVFAGGLLG 251
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 89-245 2.83e-11

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 61.09  E-value: 2.83e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736  89 FIRNNYIATIYkAIGTFLFGAAASQSLtdiaKYSIGRLRPHFLDVCDPdwskincsDGYieyyicrgnaervkegrlSFY 168
Cdd:cd03392  56 LLKRRRRAALF-LLLALLGGGALNTLL----KLLVQRPRPPLHLLVPE--------GGY------------------SFP 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736 169 SGHSSFSMYCMLFVALYLQARMKGDWARLLrptLQFGLVAVSIYVGLSRVsdYKH-HW-SDVLTGLIQG-ALVAILVAVY 245
Cdd:cd03392 105 SGHAMGATVLYGFLAYLLARRLPRRRVRIL---LLILAAILILLVGLSRL--YLGvHYpSDVLAGWLLGlAWLALLILLY 179
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 105-246 8.64e-11

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 57.73  E-value: 8.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736 105 FLFGAAASQSLTDIAKYSIGRLRPhfldvcdpdwskincsDGYIEYYicrgnaervkegrLSFYSGHSS--FSmycmlfV 182
Cdd:cd03394   8 LAEAAALTAAVTEGLKFAVGRARP----------------DGSNNGY-------------RSFPSGHTAsaFA------A 52

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29171736 183 ALYLQARMKGDWArllrptlQFGLVAVSIYVGLSRVSDYKHHWSDVLTgliqGALVAILVAVYV 246
Cdd:cd03394  53 ATFLQYRYGWRWY-------GIPAYALASLVGASRVVANRHWLSDVLA----GAAIGILVGYLV 105
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 101-246 1.26e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 50.81  E-value: 1.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736 101 AIGTFLFGAAASQSLTDIAKYSIGRLRPHFLDVCDPDwskINCSDGYieyyicrgnaervkegrlSFYSGHSSFSMYCML 180
Cdd:COG0671  74 LLLLAALLLLLLLLLLLLLKYLFGRPRPFVVPDLELL---LGTAGGY------------------SFPSGHAAAAFALAL 132

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 29171736 181 FVALYLQARmkgdWARLLrptlqfgLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYV 246
Cdd:COG0671 133 VLALLLPRR----WLAAL-------LLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 102-246 3.01e-06

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 46.55  E-value: 3.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736 102 IGTFLFGA-AASQSLTDIAKYSIGRLRPHFldvcdpdwskincsdgYIEYYICRGNAERVKEGRLSFYSGHSS--FSMyc 178
Cdd:cd03389  70 AGLFLFATvALSGILVNLLKFIIGRARPKL----------------LFDDGLYGFDPFHADYAFTSFPSGHSAtaGAA-- 131

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 29171736 179 mlFVALYLqarmkgdwarlLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILVAVYV 246
Cdd:cd03389 132 --AAALAL-----------LFPRYRWAFILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALALYQRF 186
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 169-241 1.38e-05

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 44.19  E-value: 1.38e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29171736 169 SGHSSFSMYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAIL 241
Cdd:cd03382  85 SSHSQFMGFFAVYLLLFIYLRLGRLNSLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGIL 157
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 91-242 7.67e-05

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 42.25  E-value: 7.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29171736  91 RNNYIATIYKAIGTFLFGAAAsQSLTDIAKYSIGRLRPHF-LDVCDpDWSKINCSDGYieyyicrgnaervkegrlSFYS 169
Cdd:cd03395  49 RKGPIGLLILLLVLLAVGFAD-QLASGFLKPLVARLRPCNaLDGVR-LVVLGDQGGSY------------------SFAS 108

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29171736 170 GHSSFSMYCMLFVALYLqarmkgdWARLLRPTLqfglVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAILV 242
Cdd:cd03395 109 SHAANSFALALFIWLFF-------RRGLFSPVL----LLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLLF 170
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 166-242 2.60e-03

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 37.68  E-value: 2.60e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29171736 166 SFYSGHSSFSMYCMLFVALYLqarmkgDWARLLRPTLQfgLVAVSiyVGLSRVSDYKHHWSDVLTGLIQGALVAILV 242
Cdd:cd03391  92 SFPSGHASRAAFVARFLLNHL------VLAVPLRVLLV--LWATV--VGISRVLLGRHHVLDVLAGAFLGYLEALLV 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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