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Conserved domains on  [gi|612407851|ref|NP_003629|]
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integrin alpha-8 isoform 1 preproprotein [Homo sapiens]

Protein Classification

integrin alpha( domain architecture ID 12192641)

integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 484-934 0e+00

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 562.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   484 RPVVTVDAQLLLHPMIINLENKTCQVPDSMTSaaCFSLRVCASVTGQSIAN-TIVLMAEVQLDSLKQKGAIKRTLFLDNH 562
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGTPVS--CFTVRACFSYTGKPIPNpSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   563 QAHRVFPLVIKRQKSHQCQDFIVYLRDEteFRDKLSPINISLNYSL--DESTFKEGLEVKPILNYYRENIVSEQAHILVD 640
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   641 CGEDNLCVPDLKLSARPD----KHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIeRNNKGFRPLSCEYK 716
Cdd:pfam08441  157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   717 MENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPP 796
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   797 QIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEF-LLYIFHIQTLGPLQCQPNPNINP 875
Cdd:pfam08441  316 QVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKwLLYLLDVQGQGKGECSPQNEINP 395

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   876 QDIkpaaspEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKILNCTNI-ECLQISC 934
Cdd:pfam08441  396 LNL------TQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASVLLSCDSGaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 383-437 2.20e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.47  E-value: 2.20e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 612407851    383 FGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQR-GKVLIYNGNKDGLNTKPSQVL 437
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 317-365 1.48e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.69  E-value: 1.48e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 612407851    317 MASYFGYTVV-VSDVNSDGLDDVLVGAPlfmereFESNPREVGQIYLYLQ 365
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAP------RANDAGETGAVYVYFG 44
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 54-112 2.94e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.14  E-value: 2.94e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612407851     54 GSYFGYAVDFHI---PDaRTASVLVGAPKANTSQpdivEGGAVYYCPWPAEGSaQCRQIPFD 112
Cdd:smart00191    2 GSYFGYSVAGVGdvnGD-GYPDLLVGAPRANDAG----ETGAVYVYFGSSGGG-NSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 448-492 3.33e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 42.36  E-value: 3.33e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 612407851    448 SGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQ 492
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 1035-1049 9.06e-04

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


:

Pssm-ID: 459778  Cd Length: 15  Bit Score: 37.48  E-value: 9.06e-04
                           10
                   ....*....|....*
gi 612407851  1035 KCGFFDRARPPQEDM 1049
Cdd:pfam00357    1 KCGFFKRNYPPQEEE 15
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 263-311 3.57e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 3.57e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 612407851    263 DDSYLGYSVA-AGEFTGDSQQELVAGIPRG--AQNFGYVSIIN----STDMTFIQN 311
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRAndAGETGAVYVYFgssgGGNSIPLQN 56
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 484-934 0e+00

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 562.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   484 RPVVTVDAQLLLHPMIINLENKTCQVPDSMTSaaCFSLRVCASVTGQSIAN-TIVLMAEVQLDSLKQKGAIKRTLFLDNH 562
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGTPVS--CFTVRACFSYTGKPIPNpSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   563 QAHRVFPLVIKRQKSHQCQDFIVYLRDEteFRDKLSPINISLNYSL--DESTFKEGLEVKPILNYYRENIVSEQAHILVD 640
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   641 CGEDNLCVPDLKLSARPD----KHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIeRNNKGFRPLSCEYK 716
Cdd:pfam08441  157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   717 MENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPP 796
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   797 QIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEF-LLYIFHIQTLGPLQCQPNPNINP 875
Cdd:pfam08441  316 QVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKwLLYLLDVQGQGKGECSPQNEINP 395

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   876 QDIkpaaspEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKILNCTNI-ECLQISC 934
Cdd:pfam08441  396 LNL------TQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASVLLSCDSGaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 383-437 2.20e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.47  E-value: 2.20e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 612407851    383 FGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQR-GKVLIYNGNKDGLNTKPSQVL 437
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 317-365 1.48e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.69  E-value: 1.48e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 612407851    317 MASYFGYTVV-VSDVNSDGLDDVLVGAPlfmereFESNPREVGQIYLYLQ 365
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAP------RANDAGETGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 386-422 1.89e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 48.28  E-value: 1.89e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 612407851   386 FGSAMAhLGDLNQDGYNDIAIGVPFAGKDQRGKVLIY 422
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 54-112 2.94e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.14  E-value: 2.94e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612407851     54 GSYFGYAVDFHI---PDaRTASVLVGAPKANTSQpdivEGGAVYYCPWPAEGSaQCRQIPFD 112
Cdd:smart00191    2 GSYFGYSVAGVGdvnGD-GYPDLLVGAPRANDAG----ETGAVYVYFGSSGGG-NSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 321-363 7.25e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 46.35  E-value: 7.25e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 612407851   321 FGYTVVVSDVNSDGLDDVLVGAPLFmerefesNPREVGQIYLY 363
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGE-------GGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 448-492 3.33e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 42.36  E-value: 3.33e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 612407851    448 SGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQ 492
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 1035-1049 9.06e-04

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


Pssm-ID: 459778  Cd Length: 15  Bit Score: 37.48  E-value: 9.06e-04
                           10
                   ....*....|....*
gi 612407851  1035 KCGFFDRARPPQEDM 1049
Cdd:pfam00357    1 KCGFFKRNYPPQEEE 15
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 263-311 3.57e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 3.57e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 612407851    263 DDSYLGYSVA-AGEFTGDSQQELVAGIPRG--AQNFGYVSIIN----STDMTFIQN 311
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRAndAGETGAVYVYFgssgGGNSIPLQN 56
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 268-301 7.42e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 35.18  E-value: 7.42e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 612407851   268 GYSVAAGEFTGDSQQELVAGIPRGA-QNFGYVSII 301
Cdd:pfam01839    2 GYSVAVGDLNGDGYADLAVGAPGEGgAGAGAVYVL 36
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 484-934 0e+00

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 562.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   484 RPVVTVDAQLLLHPMIINLENKTCQVPDSMTSaaCFSLRVCASVTGQSIAN-TIVLMAEVQLDSLKQKGAIKRTLFLDNH 562
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGTPVS--CFTVRACFSYTGKPIPNpSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   563 QAHRVFPLVIKRQKSHQCQDFIVYLRDEteFRDKLSPINISLNYSL--DESTFKEGLEVKPILNYYRENIVSEQAHILVD 640
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   641 CGEDNLCVPDLKLSARPD----KHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIeRNNKGFRPLSCEYK 716
Cdd:pfam08441  157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   717 MENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPP 796
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   797 QIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEF-LLYIFHIQTLGPLQCQPNPNINP 875
Cdd:pfam08441  316 QVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKwLLYLLDVQGQGKGECSPQNEINP 395

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407851   876 QDIkpaaspEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKILNCTNI-ECLQISC 934
Cdd:pfam08441  396 LNL------TQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASVLLSCDSGaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 383-437 2.20e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.47  E-value: 2.20e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 612407851    383 FGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQR-GKVLIYNGNKDGLNTKPSQVL 437
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 317-365 1.48e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.69  E-value: 1.48e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 612407851    317 MASYFGYTVV-VSDVNSDGLDDVLVGAPlfmereFESNPREVGQIYLYLQ 365
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAP------RANDAGETGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 386-422 1.89e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 48.28  E-value: 1.89e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 612407851   386 FGSAMAhLGDLNQDGYNDIAIGVPFAGKDQRGKVLIY 422
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 54-112 2.94e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.14  E-value: 2.94e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612407851     54 GSYFGYAVDFHI---PDaRTASVLVGAPKANTSQpdivEGGAVYYCPWPAEGSaQCRQIPFD 112
Cdd:smart00191    2 GSYFGYSVAGVGdvnGD-GYPDLLVGAPRANDAG----ETGAVYVYFGSSGGG-NSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 321-363 7.25e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 46.35  E-value: 7.25e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 612407851   321 FGYTVVVSDVNSDGLDDVLVGAPLFmerefesNPREVGQIYLY 363
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGE-------GGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 448-492 3.33e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 42.36  E-value: 3.33e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 612407851    448 SGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQ 492
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 329-406 5.61e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 41.83  E-value: 5.61e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612407851   329 DVNSDGLDDVLVGAPlfmerefesnprevGQIYLYLQVSSLLFRDPQILTGTETFGRFGsamAHLGDLNQDGYNDIAI 406
Cdd:pfam13517    1 DLDGDGKLDLVVAND--------------GGLRLYLNNGDGTFTFITSVSLGGGGGGLS---VAVGDLDGDGRLDLLV 61
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 1035-1049 9.06e-04

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


Pssm-ID: 459778  Cd Length: 15  Bit Score: 37.48  E-value: 9.06e-04
                           10
                   ....*....|....*
gi 612407851  1035 KCGFFDRARPPQEDM 1049
Cdd:pfam00357    1 KCGFFKRNYPPQEEE 15
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 395-470 1.41e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 37.98  E-value: 1.41e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 612407851   395 DLNQDGYNDIaigvpFAGKDQRGKVLIYNGNKDGLNTKPSQVLQGVWASHAVpsgFGftlrgdsDIDKNDYPDLIV 470
Cdd:pfam13517    1 DLDGDGKLDL-----VVANDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSVA---VG-------DLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 263-311 3.57e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 3.57e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 612407851    263 DDSYLGYSVA-AGEFTGDSQQELVAGIPRG--AQNFGYVSIIN----STDMTFIQN 311
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRAndAGETGAVYVYFgssgGGNSIPLQN 56
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 268-301 7.42e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 35.18  E-value: 7.42e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 612407851   268 GYSVAAGEFTGDSQQELVAGIPRGA-QNFGYVSII 301
Cdd:pfam01839    2 GYSVAVGDLNGDGYADLAVGAPGEGgAGAGAVYVL 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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