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Conserved domains on  [gi|4507993|ref|NP_003432|]
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zinc finger protein 141 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.80e-33

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.39  E-value: 1.80e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507993       4 LTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSLGVAISNPDLVTCLEQRKEPYN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-414 4.16e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  118 KSLNECKLQKGGYNEFNECLSTT-QSKILQCKASVKVVSKFSNSNKRKTRHTGEKHFKEC--GKSFQKFSHLTQHKVIHA 194
Cdd:COG5048 143 ISNLRNNPLPGNNSSSVNTPQSNsLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENspLSSSYSIPSSSSDQNLEN 222

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  195 GEKPYTCEECGKAFKWSLIFNEHKRIHTGEKPFTCEECGSIFTTSSHFAKHKIIHTGE-------KPYKCEECGKAFNRF 267
Cdd:COG5048 223 SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRS 302

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  268 TTLTKHKR--IHAGEKPITCEE----CRKIFTSSSNFAKHKRIHTGEKPYKCEEC-------GKAFNRSTTLTKHKRIHT 334
Cdd:COG5048 303 SPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLK 382

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  335 GEKPYTCE--ECGKAFRQSSKLNEHKKVHTGERP--YKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFRRSTDR 410
Cdd:COG5048 383 NDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLS 462


                ....
gi 4507993  411 SQHK 414
Cdd:COG5048 463 NHGK 466
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 391-471 3.22e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  391 GEKPYKCE--ECGKAFRRSTDRSQHKKI-HSADKPYKCKECDKafkqfsllsqHKKIHTVDKPYKCKDCDKAFKRFSHLN 467
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                ....
gi 4507993  468 KHKK 471
Cdd:COG5189 416 YHRK 419
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.80e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.39  E-value: 1.80e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507993       4 LTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSLGVAISNPDLVTCLEQRKEPYN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 3.50e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 94.46  E-value: 3.50e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 4507993      3 LLTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 5.34e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.60  E-value: 5.34e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 4507993    4 LTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSL 43
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-414 4.16e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  118 KSLNECKLQKGGYNEFNECLSTT-QSKILQCKASVKVVSKFSNSNKRKTRHTGEKHFKEC--GKSFQKFSHLTQHKVIHA 194
Cdd:COG5048 143 ISNLRNNPLPGNNSSSVNTPQSNsLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENspLSSSYSIPSSSSDQNLEN 222

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  195 GEKPYTCEECGKAFKWSLIFNEHKRIHTGEKPFTCEECGSIFTTSSHFAKHKIIHTGE-------KPYKCEECGKAFNRF 267
Cdd:COG5048 223 SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRS 302

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  268 TTLTKHKR--IHAGEKPITCEE----CRKIFTSSSNFAKHKRIHTGEKPYKCEEC-------GKAFNRSTTLTKHKRIHT 334
Cdd:COG5048 303 SPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLK 382

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  335 GEKPYTCE--ECGKAFRQSSKLNEHKKVHTGERP--YKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFRRSTDR 410
Cdd:COG5048 383 NDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLS 462


                ....
gi 4507993  411 SQHK 414
Cdd:COG5048 463 NHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-322 2.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 4507993    297 NFAKHKRIHTGEKPYKCEECGKAFNR 322
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 391-471 3.22e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  391 GEKPYKCE--ECGKAFRRSTDRSQHKKI-HSADKPYKCKECDKafkqfsllsqHKKIHTVDKPYKCKDCDKAFKRFSHLN 467
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                ....
gi 4507993  468 KHKK 471
Cdd:COG5189 416 YHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
438-462 8.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.58e-04
                          10        20
                  ....*....|....*....|....*
gi 4507993    438 LSQHKKIHTVDKPYKCKDCDKAFKR 462
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 1.80e-33

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 120.39  E-value: 1.80e-33
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507993       4 LTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSLGVAISNPDLVTCLEQRKEPYN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 3.50e-24

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 94.46  E-value: 3.50e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 4507993      3 LLTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 5.34e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.60  E-value: 5.34e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 4507993    4 LTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSL 43
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-414 4.16e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 4.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  118 KSLNECKLQKGGYNEFNECLSTT-QSKILQCKASVKVVSKFSNSNKRKTRHTGEKHFKEC--GKSFQKFSHLTQHKVIHA 194
Cdd:COG5048 143 ISNLRNNPLPGNNSSSVNTPQSNsLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENspLSSSYSIPSSSSDQNLEN 222

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  195 GEKPYTCEECGKAFKWSLIFNEHKRIHTGEKPFTCEECGSIFTTSSHFAKHKIIHTGE-------KPYKCEECGKAFNRF 267
Cdd:COG5048 223 SSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRS 302

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  268 TTLTKHKR--IHAGEKPITCEE----CRKIFTSSSNFAKHKRIHTGEKPYKCEEC-------GKAFNRSTTLTKHKRIHT 334
Cdd:COG5048 303 SPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLK 382

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  335 GEKPYTCE--ECGKAFRQSSKLNEHKKVHTGERP--YKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFRRSTDR 410
Cdd:COG5048 383 NDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLS 462


                ....
gi 4507993  411 SQHK 414
Cdd:COG5048 463 NHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
294-474 1.90e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 1.90e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  294 SSSNFAKHKRIHTgekPYKCEECGKAFNRSTTLTKHKR--IHTGE--KPYTCEE--CGKAFRQSSKLNEHKKVHTGERPY 367
Cdd:COG5048 276 NESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  368 KCdecgkafgrsrVLNEHKKIHTGEKPYKceecgkafrrSTDRSQHKKIHSADKPYKC--KECDKAFKQFSLLSQHKKIH 445
Cdd:COG5048 353 KE-----------KLLNSSSKFSPLLNNE----------PPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                       170       180       190
                ....*....|....*....|....*....|.
gi 4507993  446 TVDKP--YKCKDCDKAFKRFSHLNKHKKIHT 474
Cdd:COG5048 412 LSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-474 1.21e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.21e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  225 KPFTCEECGSIFTTSSHFAKHKIIHTGEKPYKC--EECGKAFNRFTTLTKHKRIHAGEKPITCEECRKIFTSSSNFAKHK 302
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  303 RIHTGE-KPYKCEECGKAFNRSTTLTKHKRIHTGEKPYTCEECGKAFRQSSKLNE----------------------HKK 359
Cdd:COG5048 112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanslskdpssnlslliSSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  360 VHTGERPYKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFRRSTDRSQHKKIHSADKPYKCKECDKAFKQFSLLS 439
Cdd:COG5048 192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 4507993  440 QHKKIHT-------VDKPYKCKDCDKAFKRFSHLNKHK--KIHT 474
Cdd:COG5048 272 SSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLrsVNHS 315
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
174-360 1.56e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  174 KECGKSFQKFSHLTQHKVIHAGE-------KPYTCEECGKAFKWSLIFNEHKR--IHTGE--KPFTCEE--CGSIFTTSS 240
Cdd:COG5048 258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRND 337

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  241 HFAKHKIIHTGEKPYKC--EECGKAFN------RFTTLTKHKRIHAGEKPITCE-ECRKIFTSSSNFAKHKRIHTGEKP- 310
Cdd:COG5048 338 ALKRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPy 417

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 4507993  311 -YKCEECGKAFNRSTTLTKHKRIHTGEKPYTCEECGKaFRQSSKLNEHKKV 360
Cdd:COG5048 418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
175-474 6.42e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 6.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  175 ECGKSFQKFSHLTQHKVIHAGEKPYTC--EECGKAFKWSLIFNEHKRIHTGEKPFTCE-ECGSIFTTSSHFAKHKIIHTG 251
Cdd:COG5048  38 NCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSSSSNS 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  252 EKPYKCEECGKAFNRFTTLTK--HKRIHAGEKPitceeCRKIFTSSSNFAKHKRIHtGEKPYKCEECGKAFNRSTTLtkH 329
Cdd:COG5048 118 NDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNP-----LPGNNSSSVNTPQSNSLH-PPLPANSLSKDPSSNLSLLI--S 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  330 KRIHTGEKPYTCEECGKAFRQSSKLNEHKKVHTGERPYKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFR--RS 407
Cdd:COG5048 190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptAS 269

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4507993  408 TDRSQHKKIHSAD-----KPYKCKECDKAFKQFSLLSQHK--KIHT--VDKPYKC--KDCDKAFKRFSHLNKHKKIHT 474
Cdd:COG5048 270 SQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCpySLCGKLFSRNDALKRHILLHT 347
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 363-443 2.19e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  363 GERPYKCD--ECGKAFGRSRVLNEHKKiHTgekpykceECGKAFRRSTDRSQHKKIHSADKPYKCKECDKAFKQFSLLSQ 440
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ...
gi 4507993  441 HKK 443
Cdd:COG5189 417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-322 2.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 4507993    297 NFAKHKRIHTGEKPYKCEECGKAFNR 322
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 251-330 3.11e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  251 GEKPYKCE--ECGKAFNRFTTLtKHKRIHAGEKPITCEECRKIftsssnfaKHKRIHTGEKPYKCEECGKAFNRSTTLTK 328
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ..
gi 4507993  329 HK 330
Cdd:COG5189 417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 391-471 3.22e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  391 GEKPYKCE--ECGKAFRRSTDRSQHKKI-HSADKPYKCKECDKafkqfsllsqHKKIHTVDKPYKCKDCDKAFKRFSHLN 467
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                ....
gi 4507993  468 KHKK 471
Cdd:COG5189 416 YHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
382-406 4.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.49e-04
                          10        20
                  ....*....|....*....|....*
gi 4507993    382 LNEHKKIHTGEKPYKCEECGKAFRR 406
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
438-462 8.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.58e-04
                          10        20
                  ....*....|....*....|....*
gi 4507993    438 LSQHKKIHTVDKPYKCKDCDKAFKR 462
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-350 9.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.74e-04
                          10        20
                  ....*....|....*....|....*
gi 4507993    326 LTKHKRIHTGEKPYTCEECGKAFRQ 350
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 195-274 1.20e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507993  195 GEKPYTCE--ECGKAFKWSLIFNEHkRIHTGEKPFTCEECGSIfttsshfaKHKIIHTGEKPYKCEECGKAFNRFTTLTK 272
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ..
gi 4507993  273 HK 274
Cdd:COG5189 417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-266 1.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.59e-03
                          10        20
                  ....*....|....*....|....*.
gi 4507993    241 HFAKHKIIHTGEKPYKCEECGKAFNR 266
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
354-376 2.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.29e-03
                          10        20
                  ....*....|....*....|...
gi 4507993    354 LNEHKKVHTGERPYKCDECGKAF 376
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 307-359 4.30e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 4.30e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4507993  307 GEKPYKCE--ECGKAFNRSTTLTKHKR-------------------IHTGEKPYTCEECGKAFRQSSKLNEHKK 359
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
412-434 7.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 7.30e-03
                          10        20
                  ....*....|....*....|...
gi 4507993    412 QHKKIHSADKPYKCKECDKAFKQ 434
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 451-473 7.48e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.48e-03
                          10        20
                  ....*....|....*....|...
gi 4507993    451 YKCKDCDKAFKRFSHLNKHKKIH 473
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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