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Conserved domains on  [gi|4507809|ref|NP_003348|]
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uteroglobin precursor [Homo sapiens]

Protein Classification

Secretoglobin domain-containing protein( domain architecture ID 11254102)

Secretoglobin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UTG smart00096
Uteroglobin;
22-90 2.76e-35

Uteroglobin;


:

Pssm-ID: 128407  Cd Length: 69  Bit Score: 114.54  E-value: 2.76e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4507809     22 EICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKLMEKIAQSSLC 90
Cdd:smart00096  1 EICPGFKRVIELLLLGTPSSYEASLKQFKPDPDMLEAGRQLKKLVDTLPQETRENILKLTEKIYTSPLC 69
 
Name Accession Description Interval E-value
UTG smart00096
Uteroglobin;
22-90 2.76e-35

Uteroglobin;


Pssm-ID: 128407  Cd Length: 69  Bit Score: 114.54  E-value: 2.76e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4507809     22 EICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKLMEKIAQSSLC 90
Cdd:smart00096  1 EICPGFKRVIELLLLGTPSSYEASLKQFKPDPDMLEAGRQLKKLVDTLPQETRENILKLTEKIYTSPLC 69
Uteroglobin pfam01099
Uteroglobin family; Uteroglobin is a homodimer of two identical 70 amino acid polypeptides ...
 1-90 1.66e-33

Uteroglobin family; Uteroglobin is a homodimer of two identical 70 amino acid polypeptides linked by two disulphide bridges. The precise role of uteroglobin has still to be elucidated.


Pssm-ID: 460063  Cd Length: 90  Bit Score: 110.76  E-value: 1.66e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507809     1 MKLAVTLTLVTLALCCSSASAEICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKL 80
Cdd:pfam01099  1 MKLSVALLLVTLALCCYAGSADGCPALEEVVEKFLFGSEEEYKESLEKYNPPPEAVEAKLELKQCFDKLSNETRLNIAKL 80

                         90
                 ....*....|
gi 4507809    81 MEKIAQSSLC 90
Cdd:pfam01099 81 LEKILLSPLC 90
Secretoglobin cd00633
Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with ...
 24-90 4.79e-20

Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity. Their family subunits may be grouped into five subfamilies, A-E. Uteroglobin (subfamily A), which is identical to Clara cell protein (CC10), forms a globular shaped homodimer with a large hydrophobic pocket located between the two dimers. The uteroglobin monomer structure is composed of four alpha helices that do not form a canonical four helix-bundle motif but rather a boomerang-shaped structure in which helices H1, H3, and H4 are able to bind a homodimeric partner. The hydrophobic pocket binds steroids, particularly progesterone, with high specificity. However, the true biological function of uteroglobin is poorly understood. In mammals, uteroglobin has immunosuppressive and anti-inflammatory properties through the inhibition of phospholipase A2. The other four main subfamilies of secretoglobins are found in heterodimeric combinations, with B and C subfamilies disulphide-bridged to the E and D subfamilies, respectively. [See review by Laukaitis C.M. _ Karn R.C. (2005). Biological Journal of the Linnean Society 84, 493]. These include rat prostatic steroid-binding protein (PBP or prostatein), human mammaglobin (or heteroglobin), lipophilins, major cat allergen Fel dI, the hamster Harderian gland proteins and mouse salivary androgen-binding protein (ABP). Example of such a heterodimer: ABPalpha-like sequences are closely related to cat Fel dI chain 1, whereas ABPbeta-gamma-like sequences are closely related to Fel dI chain 2. Thus, the heterodimeric structure of ABPalpha-beta and ABPalpha-gamma is recapitulated by the sequence-similar Fel dI chains 1 and 2. This conservation of primary and quaternary structure indicates that the genome of the eutherian common ancestor of cats, rodents, and primates contained a similar gene pair.


Pssm-ID: 238346  Cd Length: 67  Bit Score: 75.80  E-value: 4.79e-20
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4507809  24 CPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKLMEKIAQSSLC 90
Cdd:cd00633  1 CPALESVIEGFLLGSEEEYKAELEKFNATPEAVEAKEKLKQCVDEQSLETKENIAKLLEKILASPLC 67
 
Name Accession Description Interval E-value
UTG smart00096
Uteroglobin;
22-90 2.76e-35

Uteroglobin;


Pssm-ID: 128407  Cd Length: 69  Bit Score: 114.54  E-value: 2.76e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4507809     22 EICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKLMEKIAQSSLC 90
Cdd:smart00096  1 EICPGFKRVIELLLLGTPSSYEASLKQFKPDPDMLEAGRQLKKLVDTLPQETRENILKLTEKIYTSPLC 69
Uteroglobin pfam01099
Uteroglobin family; Uteroglobin is a homodimer of two identical 70 amino acid polypeptides ...
 1-90 1.66e-33

Uteroglobin family; Uteroglobin is a homodimer of two identical 70 amino acid polypeptides linked by two disulphide bridges. The precise role of uteroglobin has still to be elucidated.


Pssm-ID: 460063  Cd Length: 90  Bit Score: 110.76  E-value: 1.66e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507809     1 MKLAVTLTLVTLALCCSSASAEICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKL 80
Cdd:pfam01099  1 MKLSVALLLVTLALCCYAGSADGCPALEEVVEKFLFGSEEEYKESLEKYNPPPEAVEAKLELKQCFDKLSNETRLNIAKL 80

                         90
                 ....*....|
gi 4507809    81 MEKIAQSSLC 90
Cdd:pfam01099 81 LEKILLSPLC 90
Secretoglobin cd00633
Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with ...
 24-90 4.79e-20

Secretoglobins are relatively small, secreted, disulphide-bridged dimeric proteins with encoding genes sharing substantial sequence similarity. Their family subunits may be grouped into five subfamilies, A-E. Uteroglobin (subfamily A), which is identical to Clara cell protein (CC10), forms a globular shaped homodimer with a large hydrophobic pocket located between the two dimers. The uteroglobin monomer structure is composed of four alpha helices that do not form a canonical four helix-bundle motif but rather a boomerang-shaped structure in which helices H1, H3, and H4 are able to bind a homodimeric partner. The hydrophobic pocket binds steroids, particularly progesterone, with high specificity. However, the true biological function of uteroglobin is poorly understood. In mammals, uteroglobin has immunosuppressive and anti-inflammatory properties through the inhibition of phospholipase A2. The other four main subfamilies of secretoglobins are found in heterodimeric combinations, with B and C subfamilies disulphide-bridged to the E and D subfamilies, respectively. [See review by Laukaitis C.M. _ Karn R.C. (2005). Biological Journal of the Linnean Society 84, 493]. These include rat prostatic steroid-binding protein (PBP or prostatein), human mammaglobin (or heteroglobin), lipophilins, major cat allergen Fel dI, the hamster Harderian gland proteins and mouse salivary androgen-binding protein (ABP). Example of such a heterodimer: ABPalpha-like sequences are closely related to cat Fel dI chain 1, whereas ABPbeta-gamma-like sequences are closely related to Fel dI chain 2. Thus, the heterodimeric structure of ABPalpha-beta and ABPalpha-gamma is recapitulated by the sequence-similar Fel dI chains 1 and 2. This conservation of primary and quaternary structure indicates that the genome of the eutherian common ancestor of cats, rodents, and primates contained a similar gene pair.


Pssm-ID: 238346  Cd Length: 67  Bit Score: 75.80  E-value: 4.79e-20
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4507809  24 CPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKLMEKIAQSSLC 90
Cdd:cd00633  1 CPALESVIEGFLLGSEEEYKAELEKFNATPEAVEAKEKLKQCVDEQSLETKENIAKLLEKILASPLC 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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