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Conserved domains on  [gi|4507497|ref|NP_003242|]
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thyroid hormone-inducible hepatic protein [Homo sapiens]

Protein Classification

thyroid hormone responsive protein( domain architecture ID 10537235)

thyroid hormone responsive protein (THRSP) is a small acidic protein that is predominately expressed in lipogenic tissue and play a role in lipogenesis by responding to thyroid hormone stimulation, high glucose levels and it is localized to a chromosomal region implicated in obesity.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spot_14 pfam07084
Thyroid hormone-inducible hepatic protein Spot 14; This family consists of several thyroid ...
 2-145 1.47e-79

Thyroid hormone-inducible hepatic protein Spot 14; This family consists of several thyroid hormone-inducible hepatic protein (Spot 14 or S14) sequences. Mainly expressed in tissues that synthesize triglycerides, the mRNA coding for Spot 14 has been shown to be increased in rat liver by insulin, dietary carbohydrates, glucose in hepatocyte culture medium, as well as thyroid hormone. In contrast, dietary fats and polyunsaturated fatty acids, have been shown to decrease the amount of Spot 14 mRNA, while an elevated level of cAMP acts as a dominant negative factor. In addition, liver-specific factors or chromatin organization of the gene have been shown to contribute to the regulation of its expression. Spot 14 protein is thought to be required for induction of hepatic lipogenesis.


:

Pssm-ID: 462085  Cd Length: 151  Bit Score: 231.46  E-value: 1.47e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507497      2 QVLtKRYP-KNCLLTVMDRYAAEVHNMEQVVMIPSLLRDVQLSGPGGQAQ---------AEAPDLYTYFTMLKAICVDVD 71
Cdd:pfam07084   1 QIC-DSYPqKNSLLNAMNRFIAAVNNMDQTVMVPSLLRDVPLEEEGEDAQvgnnnpsffAGARDMYSYYTLLKSIRNDIE 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4507497     72 HGLLPREEWQAKVAGseENGTAETEEVEDESASGELDLEAQFHLHFSSLHHILMHLTEKAQEVTRKYQEMTGQV 145
Cdd:pfam07084  80 WGLLPREEWRKKDAG--ENSAAETSELEEEDAEGELDLEAQFHYHLSGLHHVLSKLTRKANELTNRYKEEIGQG 151
 
Name Accession Description Interval E-value
Spot_14 pfam07084
Thyroid hormone-inducible hepatic protein Spot 14; This family consists of several thyroid ...
 2-145 1.47e-79

Thyroid hormone-inducible hepatic protein Spot 14; This family consists of several thyroid hormone-inducible hepatic protein (Spot 14 or S14) sequences. Mainly expressed in tissues that synthesize triglycerides, the mRNA coding for Spot 14 has been shown to be increased in rat liver by insulin, dietary carbohydrates, glucose in hepatocyte culture medium, as well as thyroid hormone. In contrast, dietary fats and polyunsaturated fatty acids, have been shown to decrease the amount of Spot 14 mRNA, while an elevated level of cAMP acts as a dominant negative factor. In addition, liver-specific factors or chromatin organization of the gene have been shown to contribute to the regulation of its expression. Spot 14 protein is thought to be required for induction of hepatic lipogenesis.


Pssm-ID: 462085  Cd Length: 151  Bit Score: 231.46  E-value: 1.47e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507497      2 QVLtKRYP-KNCLLTVMDRYAAEVHNMEQVVMIPSLLRDVQLSGPGGQAQ---------AEAPDLYTYFTMLKAICVDVD 71
Cdd:pfam07084   1 QIC-DSYPqKNSLLNAMNRFIAAVNNMDQTVMVPSLLRDVPLEEEGEDAQvgnnnpsffAGARDMYSYYTLLKSIRNDIE 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4507497     72 HGLLPREEWQAKVAGseENGTAETEEVEDESASGELDLEAQFHLHFSSLHHILMHLTEKAQEVTRKYQEMTGQV 145
Cdd:pfam07084  80 WGLLPREEWRKKDAG--ENSAAETSELEEEDAEGELDLEAQFHYHLSGLHHVLSKLTRKANELTNRYKEEIGQG 151
 
Name Accession Description Interval E-value
Spot_14 pfam07084
Thyroid hormone-inducible hepatic protein Spot 14; This family consists of several thyroid ...
 2-145 1.47e-79

Thyroid hormone-inducible hepatic protein Spot 14; This family consists of several thyroid hormone-inducible hepatic protein (Spot 14 or S14) sequences. Mainly expressed in tissues that synthesize triglycerides, the mRNA coding for Spot 14 has been shown to be increased in rat liver by insulin, dietary carbohydrates, glucose in hepatocyte culture medium, as well as thyroid hormone. In contrast, dietary fats and polyunsaturated fatty acids, have been shown to decrease the amount of Spot 14 mRNA, while an elevated level of cAMP acts as a dominant negative factor. In addition, liver-specific factors or chromatin organization of the gene have been shown to contribute to the regulation of its expression. Spot 14 protein is thought to be required for induction of hepatic lipogenesis.


Pssm-ID: 462085  Cd Length: 151  Bit Score: 231.46  E-value: 1.47e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507497      2 QVLtKRYP-KNCLLTVMDRYAAEVHNMEQVVMIPSLLRDVQLSGPGGQAQ---------AEAPDLYTYFTMLKAICVDVD 71
Cdd:pfam07084   1 QIC-DSYPqKNSLLNAMNRFIAAVNNMDQTVMVPSLLRDVPLEEEGEDAQvgnnnpsffAGARDMYSYYTLLKSIRNDIE 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4507497     72 HGLLPREEWQAKVAGseENGTAETEEVEDESASGELDLEAQFHLHFSSLHHILMHLTEKAQEVTRKYQEMTGQV 145
Cdd:pfam07084  80 WGLLPREEWRKKDAG--ENSAAETSELEEEDAEGELDLEAQFHYHLSGLHHVLSKLTRKANELTNRYKEEIGQG 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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