protein Cripto isoform 1 precursor [Homo sapiens]
Protein Classification
EGF_CA and CFC domain-containing protein( domain architecture ID 10042993)
EGF_CA and CFC domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| CFC | pfam09443 | Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein ... |
115-149 | 2.49e-14 | ||
Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumours and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2. CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain. : Pssm-ID: 462800 Cd Length: 35 Bit Score: 63.83 E-value: 2.49e-14
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
83-107 | 3.45e-03 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 34.15 E-value: 3.45e-03
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| Name | Accession | Description | Interval | E-value | ||
| CFC | pfam09443 | Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein ... |
115-149 | 2.49e-14 | ||
Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumours and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2. CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain. Pssm-ID: 462800 Cd Length: 35 Bit Score: 63.83 E-value: 2.49e-14
|
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
83-107 | 3.45e-03 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 34.15 E-value: 3.45e-03
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| Name | Accession | Description | Interval | E-value | ||
| CFC | pfam09443 | Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein ... |
115-149 | 2.49e-14 | ||
Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumours and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2. CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain. Pssm-ID: 462800 Cd Length: 35 Bit Score: 63.83 E-value: 2.49e-14
|
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| EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
83-107 | 3.45e-03 | ||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 34.15 E-value: 3.45e-03
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