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Conserved domains on  [gi|152963644|ref|NP_002644|]
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pituitary homeobox 1 [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 11079034)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes; also contains an OAR domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
90-146 4.03e-30

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 108.36  E-value: 4.03e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 152963644   90 RRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRK 146
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 276-293 1.03e-04

OAR motif; The entry represents the OAR motif.


:

Pssm-ID: 461067  Cd Length: 19  Bit Score: 38.55  E-value: 1.03e-04
                          10
                  ....*....|....*...
gi 152963644  276 DTCNSSLASLRLKSKQHS 293
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHS 18
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
90-146 4.03e-30

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 108.36  E-value: 4.03e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 152963644   90 RRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRK 146
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 89-145 2.84e-25

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 95.78  E-value: 2.84e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 152963644    89 QRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWR 145
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 90-148 4.11e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 95.39  E-value: 4.11e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 152963644  90 RRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRE 148
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
36-146 1.06e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.07  E-value: 1.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963644  36 PADPREPLenSASESSDTELPEKERGGEPKGPEDSGAGGTGCGGADDPAKKKKQRRQRThfTSQQLQELEATFQRNRYPD 115
Cdd:COG5576    2 PVQPMQPL--SALESQRMPQIRTIKTTKNKREVEAADSEMKLERKQDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPS 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 152963644 116 MSMREEIAVWTNLTEPRVRVWFKNRRAKWRK 146
Cdd:COG5576   78 SITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 276-293 1.03e-04

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 38.55  E-value: 1.03e-04
                          10
                  ....*....|....*...
gi 152963644  276 DTCNSSLASLRLKSKQHS 293
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHS 18
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
90-146 4.03e-30

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 108.36  E-value: 4.03e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 152963644   90 RRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRK 146
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 89-145 2.84e-25

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 95.78  E-value: 2.84e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 152963644    89 QRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWR 145
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 90-148 4.11e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 95.39  E-value: 4.11e-25
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 152963644  90 RRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRE 148
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
36-146 1.06e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.07  E-value: 1.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 152963644  36 PADPREPLenSASESSDTELPEKERGGEPKGPEDSGAGGTGCGGADDPAKKKKQRRQRThfTSQQLQELEATFQRNRYPD 115
Cdd:COG5576    2 PVQPMQPL--SALESQRMPQIRTIKTTKNKREVEAADSEMKLERKQDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPS 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 152963644 116 MSMREEIAVWTNLTEPRVRVWFKNRRAKWRK 146
Cdd:COG5576   78 SITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 276-293 1.03e-04

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 38.55  E-value: 1.03e-04
                          10
                  ....*....|....*...
gi 152963644  276 DTCNSSLASLRLKSKQHS 293
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHS 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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