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Conserved domains on  [gi|4505423|ref|NP_002505|]
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CCN family member 3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 206-249 3.54e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


:

Pssm-ID: 465952  Cd Length: 44  Bit Score: 71.60  E-value: 3.54e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 4505423    206 CIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPC 249
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 33-95 2.22e-12

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


:

Pssm-ID: 197525  Cd Length: 75  Bit Score: 61.71  E-value: 2.22e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4505423      33 QRCPPQCPGRCPATPPTCAPGVRavLDGCSCCLVCARQRGESCS-DLEPCdeSSGLYCDRSADP 95
Cdd:smart00121   1 ARCPPCDPARCPPCPPGCAELVR--LDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGE 60
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 269-338 8.12e-11

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


:

Pssm-ID: 214482  Cd Length: 82  Bit Score: 57.80  E-value: 8.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505423     269 KSLKAIHLQFKNCTSLhTYKPRFC-GVCSD------------GRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHT 335
Cdd:smart00041   1 KSPVRQTITYNGCTSV-TVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79


                   ...
gi 4505423     336 NCP 338
Cdd:smart00041  80 NCP 82
VWC smart00214
von Willebrand factor (vWF) type C domain;
110-170 1.40e-06

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 45.20  E-value: 1.40e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4505423     110 CVFDGVIYRSGEKFQPSCKFQCTCRDGQ-IGCVPR-CQldvllPEPNCPAPRKVEVPGECCEK 170
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCPR 58
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 206-249 3.54e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 71.60  E-value: 3.54e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 4505423    206 CIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPC 249
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 33-95 2.22e-12

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 61.71  E-value: 2.22e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4505423      33 QRCPPQCPGRCPATPPTCAPGVRavLDGCSCCLVCARQRGESCS-DLEPCdeSSGLYCDRSADP 95
Cdd:smart00121   1 ARCPPCDPARCPPCPPGCAELVR--LDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGE 60
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 269-338 8.12e-11

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 57.80  E-value: 8.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505423     269 KSLKAIHLQFKNCTSLhTYKPRFC-GVCSD------------GRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHT 335
Cdd:smart00041   1 KSPVRQTITYNGCTSV-TVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79


                   ...
gi 4505423     336 NCP 338
Cdd:smart00041  80 NCP 82
IGFBP pfam00219
Insulin-like growth factor binding protein;
35-89 1.26e-10

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 56.18  E-value: 1.26e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4505423     35 CPPQC-PGRCPATPPTCAPGVraVLDGCSCCLVCARQRGESCSDLE-PCDEssGLYC 89
Cdd:pfam00219   1 CPPPCdPERCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCGK--GLRC 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
110-170 1.40e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 45.20  E-value: 1.40e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4505423     110 CVFDGVIYRSGEKFQPSCKFQCTCRDGQ-IGCVPR-CQldvllPEPNCPAPRKVEVPGECCEK 170
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCPR 58
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 110-169 2.13e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 44.34  E-value: 2.13e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505423    110 CVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCvprcqLDVLLPEPNCPAPRKVEVPGECCE 169
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLC-----DKIICPPLDCPNPRLEIPPGECCP 55
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 261-347 1.82e-05

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 43.16  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505423    261 GKKCLRTKKSlkaIHLQFKNCTSLHTYKPRFC-GVC--------------SDGRCCTPHNTKTIQAEFQCSPGQIVKKPV 325
Cdd:pfam00007   1 RKKCIPTNYT---ISVEKEGCTSCKTINTTICaGYCytrdpvykdgrravSQRVCTYRDVTYETVVLPGCPPGVDPTVTY 77

                          90       100
                  ....*....|....*....|..
gi 4505423    326 MVIGTCTCHtNCPKNNEAFLQE 347
Cdd:pfam00007  78 PVALSCHCG-NCPTDNSDCTRL 98
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 206-249 3.54e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 71.60  E-value: 3.54e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 4505423    206 CIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPC 249
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 33-95 2.22e-12

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 61.71  E-value: 2.22e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4505423      33 QRCPPQCPGRCPATPPTCAPGVRavLDGCSCCLVCARQRGESCS-DLEPCdeSSGLYCDRSADP 95
Cdd:smart00121   1 ARCPPCDPARCPPCPPGCAELVR--LDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGE 60
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 269-338 8.12e-11

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 57.80  E-value: 8.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505423     269 KSLKAIHLQFKNCTSLhTYKPRFC-GVCSD------------GRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHT 335
Cdd:smart00041   1 KSPVRQTITYNGCTSV-TVKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79


                   ...
gi 4505423     336 NCP 338
Cdd:smart00041  80 NCP 82
IGFBP pfam00219
Insulin-like growth factor binding protein;
35-89 1.26e-10

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 56.18  E-value: 1.26e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4505423     35 CPPQC-PGRCPATPPTCAPGVraVLDGCSCCLVCARQRGESCSDLE-PCDEssGLYC 89
Cdd:pfam00219   1 CPPPCdPERCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTpPCGK--GLRC 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
110-170 1.40e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 45.20  E-value: 1.40e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4505423     110 CVFDGVIYRSGEKFQPSCKFQCTCRDGQ-IGCVPR-CQldvllPEPNCPAPRKVEVPGECCEK 170
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCPR 58
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 110-169 2.13e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 44.34  E-value: 2.13e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505423    110 CVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCvprcqLDVLLPEPNCPAPRKVEVPGECCE 169
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLC-----DKIICPPLDCPNPRLEIPPGECCP 55
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 261-347 1.82e-05

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 43.16  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505423    261 GKKCLRTKKSlkaIHLQFKNCTSLHTYKPRFC-GVC--------------SDGRCCTPHNTKTIQAEFQCSPGQIVKKPV 325
Cdd:pfam00007   1 RKKCIPTNYT---ISVEKEGCTSCKTINTTICaGYCytrdpvykdgrravSQRVCTYRDVTYETVVLPGCPPGVDPTVTY 77

                          90       100
                  ....*....|....*....|..
gi 4505423    326 MVIGTCTCHtNCPKNNEAFLQE 347
Cdd:pfam00007  78 PVALSCHCG-NCPTDNSDCTRL 98
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 211-249 1.32e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.49  E-value: 1.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 4505423    211 TEWTACSKSCGMGFSTRV-------TNRNRQCEMLKQTRLCMVRPC 249
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRTrtvivepQNGGRPCPELLERRPCNLPPC 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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