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Conserved domains on  [gi|4505355|ref|NP_002479|]
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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform 1 [Homo sapiens]

Protein Classification

L51/S25/CI-B8 domain-containing protein( domain architecture ID 10658532)

L51/S25/CI-B8 domain-containing protein adopts a minimal thioredoxin-like fold, such as ribosomal proteins L51 and S25, and the mitochondrial NADH-ubiquinone oxidoreductase B8 subunit (CI-B8)

CATH:  3.40.30.10
PubMed:  15341729|7788290|15558583
SCOP:  4002951

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
L51_S25_CI-B8 smart00916
Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; Proteins containing this domain are ...
 28-97 2.78e-27

Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; Proteins containing this domain are located in the mitochondrion and include ribosomal protein L51, and S25. This domain is also found in mitochondrial NADH-ubiquinone oxidoreductase B8 subunit (CI-B8) . It is not known whether all members of this family form part of the NADH-ubiquinone oxidoreductase and whether they are also all ribosomal proteins.


:

Pssm-ID: 197984  Cd Length: 70  Bit Score: 94.51  E-value: 2.78e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505355     28 PGSQGVRDFIEKRYVELKKANPDLPILIRECSDVQPKLWARYAFGQETNVPLNNFSADQVTRALENVLSG 97
Cdd:smart00916  1 GSSAGARKFLESNLPTLKFKNPDVPILVRERSGVVPKLTAEYENGREKEISLRNLSAEEILKKLQLLVNS 70
 
Name Accession Description Interval E-value
L51_S25_CI-B8 smart00916
Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; Proteins containing this domain are ...
 28-97 2.78e-27

Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; Proteins containing this domain are located in the mitochondrion and include ribosomal protein L51, and S25. This domain is also found in mitochondrial NADH-ubiquinone oxidoreductase B8 subunit (CI-B8) . It is not known whether all members of this family form part of the NADH-ubiquinone oxidoreductase and whether they are also all ribosomal proteins.


Pssm-ID: 197984  Cd Length: 70  Bit Score: 94.51  E-value: 2.78e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505355     28 PGSQGVRDFIEKRYVELKKANPDLPILIRECSDVQPKLWARYAFGQETNVPLNNFSADQVTRALENVLSG 97
Cdd:smart00916  1 GSSAGARKFLESNLPTLKFKNPDVPILVRERSGVVPKLTAEYENGREKEISLRNLSAEEILKKLQLLVNS 70
L51_S25_CI-B8 pfam05047
Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; The proteins in this family are ...
 33-84 3.15e-18

Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; The proteins in this family are located in the mitochondrion. The family includes ribosomal protein L51, and S25. This family also includes mitochondrial NADH-ubiquinone oxidoreductase B8 subunit (CI-B8) EC:1.6.5.3. It is not known whether all members of this family form part of the NADH-ubiquinone oxidoreductase and whether they are also all ribosomal proteins. Structurally related to thioredoxin-fold.


Pssm-ID: 428280  Cd Length: 52  Bit Score: 71.06  E-value: 3.15e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 4505355    33 VRDFIEKRYVELKKANPDLPILIRECSDVQPKLWARYAFGQETNVPLNNFSA 84
Cdd:pfam05047  1 ARDFLEKNLPTLKYKNPQVPILVRERSGKHPRLLARYGNGREKTISLRNLSA 52
 
Name Accession Description Interval E-value
L51_S25_CI-B8 smart00916
Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; Proteins containing this domain are ...
 28-97 2.78e-27

Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; Proteins containing this domain are located in the mitochondrion and include ribosomal protein L51, and S25. This domain is also found in mitochondrial NADH-ubiquinone oxidoreductase B8 subunit (CI-B8) . It is not known whether all members of this family form part of the NADH-ubiquinone oxidoreductase and whether they are also all ribosomal proteins.


Pssm-ID: 197984  Cd Length: 70  Bit Score: 94.51  E-value: 2.78e-27
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505355     28 PGSQGVRDFIEKRYVELKKANPDLPILIRECSDVQPKLWARYAFGQETNVPLNNFSADQVTRALENVLSG 97
Cdd:smart00916  1 GSSAGARKFLESNLPTLKFKNPDVPILVRERSGVVPKLTAEYENGREKEISLRNLSAEEILKKLQLLVNS 70
L51_S25_CI-B8 pfam05047
Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; The proteins in this family are ...
 33-84 3.15e-18

Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; The proteins in this family are located in the mitochondrion. The family includes ribosomal protein L51, and S25. This family also includes mitochondrial NADH-ubiquinone oxidoreductase B8 subunit (CI-B8) EC:1.6.5.3. It is not known whether all members of this family form part of the NADH-ubiquinone oxidoreductase and whether they are also all ribosomal proteins. Structurally related to thioredoxin-fold.


Pssm-ID: 428280  Cd Length: 52  Bit Score: 71.06  E-value: 3.15e-18
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 4505355    33 VRDFIEKRYVELKKANPDLPILIRECSDVQPKLWARYAFGQETNVPLNNFSA 84
Cdd:pfam05047  1 ARDFLEKNLPTLKYKNPQVPILVRERSGKHPRLLARYGNGREKTISLRNLSA 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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