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Conserved domains on  [gi|4504947|ref|NP_002280|]
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alpha-lactalbumin precursor [Homo sapiens]

Protein Classification

lysozyme family protein; bifunctional lytic transglycosylase/C40 family peptidase( domain architecture ID 11081454)

lysozyme family protein| bifunctional lytic transglycosylase/C40 family peptidase may catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and/or cleave peptide cross-bridges between glycan chains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 20-138 2.36e-75

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


:

Pssm-ID: 395016  Cd Length: 123  Bit Score: 219.99  E-value: 2.36e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504947     20 KQFTKCELSQLLK--DIDGYGGIALPELICTMFHTSGYDTQAIVENNESTEYGLFQISNKLWCKSSQVPQSRNICDISCD 97
Cdd:pfam00062   1 KQFTRCELARELKklGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNGSTDYGIFQINDKYWCKDGKTPQSVNICGISCD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 4504947     98 KFLDDDITDDIMCAKKILDIKGIDYWLAHKALCTEKLEQWL 138
Cdd:pfam00062  81 KLLDDDITDDIMCAKKILDPQGIDAWLAWKPHCSEDLEQWI 121
 
Name Accession Description Interval E-value
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 20-138 2.36e-75

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 219.99  E-value: 2.36e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504947     20 KQFTKCELSQLLK--DIDGYGGIALPELICTMFHTSGYDTQAIVENNESTEYGLFQISNKLWCKSSQVPQSRNICDISCD 97
Cdd:pfam00062   1 KQFTRCELARELKklGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNGSTDYGIFQINDKYWCKDGKTPQSVNICGISCD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 4504947     98 KFLDDDITDDIMCAKKILDIKGIDYWLAHKALCTEKLEQWL 138
Cdd:pfam00062  81 KLLDDDITDDIMCAKKILDPQGIDAWLAWKPHCSEDLEQWI 121
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 21-139 6.50e-70

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 206.13  E-value: 6.50e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504947   21 QFTKCELSQLLKDI--DGYGGIALPELICTMFHTSGYDTQAIVENNESTEYGLFQISNKLWCKSSQVPQSRNICDISCDK 98
Cdd:cd16898   2 IFTKCELSQILKEHglDGFNGISLPEWICVTFHTSGYDTQALVYNNGSTEYGLFQISNKGWCDDSQEPVSRNICGISCSK 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 4504947   99 FLDDDITDDIMCAKKILDI-KGIDYWLAHKALCTEKLEQWLC 139
Cdd:cd16898  82 LLDDDITDDIACAKKILAIpKGIDYWKAHKPFCREDLDQWRC 123
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
20-140 2.79e-69

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 204.45  E-value: 2.79e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504947      20 KQFTKCELSQLLKD--IDGYGGIALPELICTMFHTSGYDTQAIVENNE-STEYGLFQISNKLWCKSSQVPQSRNICDISC 96
Cdd:smart00263   1 KVFTRCELARELKRlgLDGYRGISLANWVCLAFHESGYNTQATNYNNGgSTDYGIFQINSKYWCNDGKTPGSVNACGISC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 4504947      97 DKFLDDDITDDIMCAKKILDIKGIDYWLAHKALC-TEKLEQWL--CE 140
Cdd:smart00263  81 SKLLDDDITDDVKCAKKIVSDQGIDAWVAWKNHCqGEDLSQWIrgCG 127
 
Name Accession Description Interval E-value
Lys pfam00062
C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of ...
 20-138 2.36e-75

C-type lysozyme/alpha-lactalbumin family; Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.


Pssm-ID: 395016  Cd Length: 123  Bit Score: 219.99  E-value: 2.36e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504947     20 KQFTKCELSQLLK--DIDGYGGIALPELICTMFHTSGYDTQAIVENNESTEYGLFQISNKLWCKSSQVPQSRNICDISCD 97
Cdd:pfam00062   1 KQFTRCELARELKklGMDGYRGISLAEWVCLAFHESGYDTQAIVYNNGSTDYGIFQINDKYWCKDGKTPQSVNICGISCD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 4504947     98 KFLDDDITDDIMCAKKILDIKGIDYWLAHKALCTEKLEQWL 138
Cdd:pfam00062  81 KLLDDDITDDIMCAKKILDPQGIDAWLAWKPHCSEDLEQWI 121
LYZ_LA cd16898
alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding ...
 21-139 6.50e-70

alpha lactalbumin; alpha-lactalbumin (lactose synthase B protein, LA) is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.


Pssm-ID: 340384  Cd Length: 123  Bit Score: 206.13  E-value: 6.50e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504947   21 QFTKCELSQLLKDI--DGYGGIALPELICTMFHTSGYDTQAIVENNESTEYGLFQISNKLWCKSSQVPQSRNICDISCDK 98
Cdd:cd16898   2 IFTKCELSQILKEHglDGFNGISLPEWICVTFHTSGYDTQALVYNNGSTEYGLFQISNKGWCDDSQEPVSRNICGISCSK 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 4504947   99 FLDDDITDDIMCAKKILDI-KGIDYWLAHKALCTEKLEQWLC 139
Cdd:cd16898  82 LLDDDITDDIACAKKILAIpKGIDYWKAHKPFCREDLDQWRC 123
LYZ cd00119
C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1, ...
 20-138 1.36e-69

C-type lysozyme and alpha-lactalbumin; C-type lysozyme (chicken or conventional type, 1,4-beta-N-acetylmuramidase) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have primarily bacteriolytic function; hydrolysis of peptidoglycans of prokaryotic cell walls and transglycosylation. LA is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose. Some lysozymes have evolved into digestive enzymes, both in mammals and invertebrates.


Pssm-ID: 340357  Cd Length: 122  Bit Score: 205.11  E-value: 1.36e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504947   20 KQFTKCELSQLLKDIDGYGGIALPELICTMFHTSGYDTQAIVEN-NESTEYGLFQISNKLWCKSSQVPQSRNICDISCDK 98
Cdd:cd00119   1 KVFTRCELARLLKDIGGYGGISLPNWVCLMKHESGYDTQATNENnNGSTDYGLFQINSRYWCKDGQTPGARNICDISCSK 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 4504947   99 FLDDDITDDIMCAKKILDIKGIDYWLAHKALCTEKLEQWL 138
Cdd:cd00119  81 LLTDDITDAIMCAKKIVDDKGIDAWVAWKNHCQNKLRQYV 120
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
20-140 2.79e-69

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 204.45  E-value: 2.79e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504947      20 KQFTKCELSQLLKD--IDGYGGIALPELICTMFHTSGYDTQAIVENNE-STEYGLFQISNKLWCKSSQVPQSRNICDISC 96
Cdd:smart00263   1 KVFTRCELARELKRlgLDGYRGISLANWVCLAFHESGYNTQATNYNNGgSTDYGIFQINSKYWCNDGKTPGSVNACGISC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 4504947      97 DKFLDDDITDDIMCAKKILDIKGIDYWLAHKALC-TEKLEQWL--CE 140
Cdd:smart00263  81 SKLLDDDITDDVKCAKKIVSDQGIDAWVAWKNHCqGEDLSQWIrgCG 127
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 20-139 1.06e-37

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 124.69  E-value: 1.06e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504947   20 KQFTKCELSQLLKD--IDGYGGIALPELICTMFHTSGYDTQAIVENNE-STEYGLFQISNKLWCKSSQVPqSRNICDISC 96
Cdd:cd16897   1 KIFSRCELARILKRggLDGYRGYSLANWVCLAYYESGFNTRATNENPDgSTDYGIFQINSRYWCNDGKTP-SKNLCHISC 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 4504947   97 DKFLDDDITDDIMCAKKIL-DIKGIDYWLAHKALCTEK-LEQWLC 139
Cdd:cd16897  80 SDLLNDDITDDIKCAKKIVkDPQGMGAWVAWRLHCEGRdLSRWLD 124
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 20-133 1.49e-30

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 106.16  E-value: 1.49e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504947   20 KQFTKCELSQLLKDIdgygGIA---LPELICTMFHTSGYDTQAIVE--NNESTEYGLFQISNKLWCKSSQvpQSRNICDI 94
Cdd:cd16899   1 KIFTRCELARELRKL----GVPrsqLANWVCLAEHESSFNTTAVGGpnSDGSGDYGLFQINDKYWCSPGG--GSGNGCNV 74

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 4504947   95 SCDKFLDDDITDDIMCAKKILDIKGIDYWLAHKALCTEK 133
Cdd:cd16899  75 KCEDLLDDDISDDVKCAKKIYKEQGFNAWVGWKNKCKGK 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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