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Conserved domains on  [gi|4503287|ref|NP_001915|]
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growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1 [Homo sapiens]

Protein Classification

ribosomal L7Ae/L30e/S12e/Gadd45 family protein( domain architecture ID 10472466)

ribosomal L7Ae/L30e/S12e/Gadd45 family protein belongs to a family of K-turn-binding proteins that are important in ribosome structure, the site-specific modification of RNA, and spliceosome assembly

CATH:  3.30.1330.30
Gene Ontology:  GO:0003735|GO:0042274
PubMed:  24149842|24524803|7622064

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L7Ae pfam01248
Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from ...
 21-123 2.65e-17

Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.


:

Pssm-ID: 426153 [Multi-domain]  Cd Length: 95  Bit Score: 72.24  E-value: 2.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503287     21 DALEEVLSKALSQRTITVGVYEAAKLLNVDpdNVVLCLLAADEDDDRDVALqihftlIQAFCCENDINILRVSNPGRLAE 100
Cdd:pfam01248   1 DAIYEVLKKALKTGKLVLGLKEVTKALERG--EAKLVIIAEDCDPEEKVKL------IPALCKEKNVPYVKVPSKKELGE 72

                          90       100
                  ....*....|....*....|...
gi 4503287    101 LLLLETDAGPAASEGAEQPPDLH 123
Cdd:pfam01248  73 ACGKKRPVSALAIKDEGDSKILV 95
 
Name Accession Description Interval E-value
Ribosomal_L7Ae pfam01248
Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from ...
 21-123 2.65e-17

Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.


Pssm-ID: 426153 [Multi-domain]  Cd Length: 95  Bit Score: 72.24  E-value: 2.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503287     21 DALEEVLSKALSQRTITVGVYEAAKLLNVDpdNVVLCLLAADEDDDRDVALqihftlIQAFCCENDINILRVSNPGRLAE 100
Cdd:pfam01248   1 DAIYEVLKKALKTGKLVLGLKEVTKALERG--EAKLVIIAEDCDPEEKVKL------IPALCKEKNVPYVKVPSKKELGE 72

                          90       100
                  ....*....|....*....|...
gi 4503287    101 LLLLETDAGPAASEGAEQPPDLH 123
Cdd:pfam01248  73 ACGKKRPVSALAIKDEGDSKILV 95
 
Name Accession Description Interval E-value
Ribosomal_L7Ae pfam01248
Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from ...
 21-123 2.65e-17

Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.


Pssm-ID: 426153 [Multi-domain]  Cd Length: 95  Bit Score: 72.24  E-value: 2.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503287     21 DALEEVLSKALSQRTITVGVYEAAKLLNVDpdNVVLCLLAADEDDDRDVALqihftlIQAFCCENDINILRVSNPGRLAE 100
Cdd:pfam01248   1 DAIYEVLKKALKTGKLVLGLKEVTKALERG--EAKLVIIAEDCDPEEKVKL------IPALCKEKNVPYVKVPSKKELGE 72

                          90       100
                  ....*....|....*....|...
gi 4503287    101 LLLLETDAGPAASEGAEQPPDLH 123
Cdd:pfam01248  73 ACGKKRPVSALAIKDEGDSKILV 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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