NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|48255949|ref|NP_001674|]
View 

plasma membrane calcium-transporting ATPase 2 isoform 2 [Homo sapiens]

Protein Classification

plasma membrane calcium-transporting ATPase( domain architecture ID 13522140)

plasma membrane calcium-transporting ATPase functions to export Ca(2+) from cells and plays a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
ATPase-IIB_Ca super family cl36924
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
12-1042 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


The actual alignment was detected with superfamily member TIGR01517:

Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1334.80  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949     12 KNQRNESSHGGEFGCTMEELRSLMELRGTEAV---VKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIP 88
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949     89 PKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHP-PGEGNEgcataqggaedegEAEAGWIEGAAILLSVICVVLV 167
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDKA-------------DTETGWIEGVAILVSVILVVLV 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    168 TAFNDWSKEKQFRGLQsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247
Cdd:TIGR01517  148 TAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDP 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    248 VRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGeeeekkdkkakqqdgaaamemqplksaeggdadd 327
Cdd:TIGR01517  227 IKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAG---------------------------------- 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    328 rkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPwlpECTPVYVQYFVKFFIIGVTVLV 407
Cdd:TIGR01517  273 --------EEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAVTIVV 341
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    408 VAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPD--PSSI 485
Cdd:TIGR01517  342 VAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDEivLRNL 421
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    486 NTKTMELLINAIAINSayttkILPPEKE-GALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSM 564
Cdd:TIGR01517  422 PAAVRNILVEGISLNS-----SSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERKFM 496
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    565 STVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDN 644
Cdd:TIGR01517  497 SVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISEDDKDR-CADVIEPLASDALRTICLAYRDFAPEEFPRKDY 575
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    645 ENdilNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfLCLEGKEFNRRIRNE 724
Cdd:TIGR01517  576 PN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVYEE 650
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    725 kgeieqerIDKIWPKLRVLARSSPTDKHTLVKGIIDsthteQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS 804
Cdd:TIGR01517  651 --------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEAS 717
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    805 DIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLALAT 882
Cdd:TIGR01517  718 DIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALALAT 797
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    883 EPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPlHSPPSEHYTIIFNTFVMMQL 962
Cdd:TIGR01517  798 EPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLLQL 876
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    963 FNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTS 1042
Cdd:TIGR01517  877 FNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIPVE 956
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1081-1127 1.16e-26

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


:

Pssm-ID: 463575  Cd Length: 47  Bit Score: 103.25  E-value: 1.16e-26
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 48255949   1081 GQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPE 1127
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
12-1042 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1334.80  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949     12 KNQRNESSHGGEFGCTMEELRSLMELRGTEAV---VKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIP 88
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949     89 PKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHP-PGEGNEgcataqggaedegEAEAGWIEGAAILLSVICVVLV 167
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDKA-------------DTETGWIEGVAILVSVILVVLV 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    168 TAFNDWSKEKQFRGLQsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247
Cdd:TIGR01517  148 TAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDP 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    248 VRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGeeeekkdkkakqqdgaaamemqplksaeggdadd 327
Cdd:TIGR01517  227 IKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAG---------------------------------- 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    328 rkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPwlpECTPVYVQYFVKFFIIGVTVLV 407
Cdd:TIGR01517  273 --------EEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAVTIVV 341
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    408 VAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPD--PSSI 485
Cdd:TIGR01517  342 VAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDEivLRNL 421
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    486 NTKTMELLINAIAINSayttkILPPEKE-GALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSM 564
Cdd:TIGR01517  422 PAAVRNILVEGISLNS-----SSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERKFM 496
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    565 STVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDN 644
Cdd:TIGR01517  497 SVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISEDDKDR-CADVIEPLASDALRTICLAYRDFAPEEFPRKDY 575
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    645 ENdilNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfLCLEGKEFNRRIRNE 724
Cdd:TIGR01517  576 PN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVYEE 650
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    725 kgeieqerIDKIWPKLRVLARSSPTDKHTLVKGIIDsthteQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS 804
Cdd:TIGR01517  651 --------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEAS 717
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    805 DIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLALAT 882
Cdd:TIGR01517  718 DIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALALAT 797
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    883 EPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPlHSPPSEHYTIIFNTFVMMQL 962
Cdd:TIGR01517  798 EPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLLQL 876
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    963 FNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTS 1042
Cdd:TIGR01517  877 FNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
75-906 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1324.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   75 LEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGnegcataqggaedegEAEAGWIEG 154
Cdd:cd02081    1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGEG---------------EGKTGWIEG 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  155 AAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDL 234
Cdd:cd02081   66 VAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDL 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  235 KIDESSLTGESDQVRKSVD---KDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGeeeekkdkkakqqdgaaa 311
Cdd:cd02081  145 KIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAEN------------------ 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  312 memqplksaeggdaddrkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWlpecTPVY 391
Cdd:cd02081  207 ------------------------EEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFIIDGFVNDGKSF----SAED 258
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  392 VQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYV 471
Cdd:cd02081  259 LQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTQNRMTVVQGYI 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  472 GdvhykeipdpssintktmellinaiainsayttkilppekegalprqvgNKTECGLLGFVLDLKQDYePVRSQMPEEKL 551
Cdd:cd02081  339 G-------------------------------------------------NKTECALLGFVLELGGDY-RYREKRPEEKV 368
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  552 YKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEpRVFRPRDRDEMVKKVIEPMACDGLRTICVAY 631
Cdd:cd02081  369 LKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIKRVIEPMASDSLRTIGLAY 447
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  632 RDFPSSPEP----DWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGE 707
Cdd:cd02081  448 RDFSPDEEPtaerDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGE 527
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  708 DFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSthteqRQVVAVTGDGTNDGPALKKAD 787
Cdd:cd02081  528 DGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEVVAVTGDGTNDAPALKKAD 602
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  788 VGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLW 867
Cdd:cd02081  603 VGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIGAVVTKDSPLTAVQMLW 682
                        810       820       830
                 ....*....|....*....|....*....|....*....
gi 48255949  868 VNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTM 906
Cdd:cd02081  683 VNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
52-1036 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 681.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVtliileiaaiisL--------GLSF 123
Cdd:COG0474   12 SAEEVLAELGTSE-EGL--SSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNP------------LilillaaaVISA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  124 yhppgegnegcATaqggaedeGEaeagWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVVRAGQVVQI 203
Cdd:COG0474   77 -----------LL--------GD----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAP--TARVLRDGKWVEI 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  204 PVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSV----------DKDPMLLSGTHVMEGSGRMLV 273
Cdd:COG0474  132 PAEELVPGDIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSAdplpedaplgDRGNMVFMGTLVTSGRGTAVV 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  274 TAVGVNSQTGIIftllgaggeeeekkdkkakqqdgaAAMemqpLKSAEggdaddrkkasmhkKEKSVLQGKLTKLAVQIG 353
Cdd:COG0474  212 VATGMNTEFGKI------------------------AKL----LQEAE--------------EEKTPLQKQLDRLGKLLA 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  354 KAGLVMSAITVIILVLYftvdtfvvnKKPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDN 433
Cdd:COG0474  250 IIALVLAALVFLIGLLR---------GGPLL------------EALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRN 308
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  434 NLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYkeipDPSSINTKTMELLINAIAINSAYTtkiLPPEKE 513
Cdd:COG0474  309 AIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY----EVTGEFDPALEELLRAAALCSDAQ---LEEETG 381
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  514 galprqVGNKTECGLLGFVLDLKQDYEPVRSQMPeekLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKI 593
Cdd:COG0474  382 ------LGDPTEGALLVAAAKAGLDVEELRKEYP---RVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEVVLALCTRV 452
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  594 LNGaGEPRVFRPRDRDEMVKKVIEpMACDGLRTICVAYRDFPSSPEPDwdnENDILNELTCICVVGIEDPVRPEVPEAIR 673
Cdd:COG0474  453 LTG-GGVVPLTEEDRAEILEAVEE-LAAQGLRVLAVAYKELPADPELD---SEDDESDLTFLGLVGMIDPPRPEAKEAIA 527
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  674 KCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDflCLEGKEFNRrirneKGEIE-QERIDKIwpklRVLARSSPTDKH 752
Cdd:COG0474  528 ECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA-----MSDEElAEAVEDV----DVFARVSPEHKL 596
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  753 TLVKGIidsthteQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSI 830
Cdd:COG0474  597 RIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNI 669
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  831 SKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNI 910
Cdd:COG0474  670 RKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRI 749
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  911 LGHAVYQLALIFTLLFVGekmfqIDSGRNAPLHSppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIFRNPIFCT 989
Cdd:COG0474  750 LLLGLLIAIFTLLTFALA-----LARGASLALAR------TMAFTTLVLSQLFNVFNCRSER--RSFFKsGLFPNRPLLL 816
                        970       980       990      1000
                 ....*....|....*....|....*....|....*....|....*....
gi 48255949  990 IVLGTFAIQIVIVQ--FGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVI 1036
Cdd:COG0474  817 AVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLILGLALLYLLLVELV 865
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
858-1036 1.73e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 173.19  E-value: 1.73e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    858 SPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSG 937
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    938 RNAplhsppsehYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCSPLQ 1015
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 48255949   1016 LDQWMWCIFIGLGELVWGQVI 1036
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
52-848 9.14e-44

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 172.56  E-value: 9.14e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQD-----VTLiileiaaiisLGLSFYhp 126
Cdd:PRK10517   53 PEEELWKTFDTHP-EGL--NEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNpfnilLTI----------LGAISY-- 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   127 pgegnegcATaqggaEDEGeaeagwiegAAILLSVIcVVLVTAFNDWSKEKQFRG---LQSRIEQeqKFTVVRAGQV--- 200
Cdd:PRK10517  118 --------AT-----EDLF---------AAGVIALM-VAISTLLNFIQEARSTKAadaLKAMVSN--TATVLRVINDkge 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   201 ---VQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRK-----------SVDKDPMLLSGTHVME 266
Cdd:PRK10517  173 ngwLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKfattrqpehsnPLECDTLCFMGTNVVS 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   267 GSGRMLVTAVGVNSQTGIIftllgaggeeeekkdkkakqqdgaaamemqplksAEGGDADDRkkasmhkkEKSVLQGKLT 346
Cdd:PRK10517  253 GTAQAVVIATGANTWFGQL----------------------------------AGRVSEQDS--------EPNAFQQGIS 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   347 KLAVQIGKAGLVMSAitVIILVLYFTvdtfvvnKKPWlpectpvyvqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSV 426
Cdd:PRK10517  291 RVSWLLIRFMLVMAP--VVLLINGYT-------KGDW------------WEAALFALSVAVGLTPEMLPMIVTSTLARGA 349
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   427 KKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtVVQAYVgDVHYKeipdpssintKTMELLINAIaINSAYTTK 506
Cdd:PRK10517  350 VKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKI-VLENHT-DISGK----------TSERVLHSAW-LNSHYQTG 416
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   507 IlppekEGALPRQVgnkTECGLLGFVLDLKQDYEPVrSQMPeeklykvytFNSVRKSMSTVIKLPDESFRMYSKGASEIV 586
Cdd:PRK10517  417 L-----KNLLDTAV---LEGVDEESARSLASRWQKI-DEIP---------FDFERRRMSVVVAENTEHHQLICKGALEEI 478
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   587 LKKCCKI-LNGAGEPRVfrpRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEpDWD--NENDilneLTCICVVGIEDP 663
Cdd:PRK10517  479 LNVCSQVrHNGEIVPLD---DIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREG-DYQraDESD----LILEGYIAFLDP 550
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   664 VRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGedflCLEGkefnrrirnekGEIEQ---ERIDKIWPKL 740
Cdd:PRK10517  551 PKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGLDAGE----VLIG-----------SDIETlsdDELANLAERT 615
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   741 RVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAV 820
Cdd:PRK10517  616 TLFARLTPMHKERIVTLLKREGH-----VVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADIILLEKSLMVLEEGV 689
                         810       820       830
                  ....*....|....*....|....*....|...
gi 48255949   821 MWGRNVYDSISKFLqfQLTV-----NVVAVIVA 848
Cdd:PRK10517  690 IEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1081-1127 1.16e-26

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 103.25  E-value: 1.16e-26
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 48255949   1081 GQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPE 1127
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
12-1042 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1334.80  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949     12 KNQRNESSHGGEFGCTMEELRSLMELRGTEAV---VKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIP 88
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949     89 PKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHP-PGEGNEgcataqggaedegEAEAGWIEGAAILLSVICVVLV 167
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDKA-------------DTETGWIEGVAILVSVILVVLV 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    168 TAFNDWSKEKQFRGLQsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247
Cdd:TIGR01517  148 TAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDP 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    248 VRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGeeeekkdkkakqqdgaaamemqplksaeggdadd 327
Cdd:TIGR01517  227 IKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAG---------------------------------- 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    328 rkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPwlpECTPVYVQYFVKFFIIGVTVLV 407
Cdd:TIGR01517  273 --------EEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAVTIVV 341
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    408 VAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPD--PSSI 485
Cdd:TIGR01517  342 VAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDEivLRNL 421
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    486 NTKTMELLINAIAINSayttkILPPEKE-GALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSM 564
Cdd:TIGR01517  422 PAAVRNILVEGISLNS-----SSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERKFM 496
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    565 STVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDN 644
Cdd:TIGR01517  497 SVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISEDDKDR-CADVIEPLASDALRTICLAYRDFAPEEFPRKDY 575
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    645 ENdilNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfLCLEGKEFNRRIRNE 724
Cdd:TIGR01517  576 PN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVYEE 650
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    725 kgeieqerIDKIWPKLRVLARSSPTDKHTLVKGIIDsthteQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS 804
Cdd:TIGR01517  651 --------MDPILPKLRVLARSSPLDKQLLVLMLKD-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEAS 717
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    805 DIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLALAT 882
Cdd:TIGR01517  718 DIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALALAT 797
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    883 EPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAPlHSPPSEHYTIIFNTFVMMQL 962
Cdd:TIGR01517  798 EPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLLQL 876
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    963 FNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTS 1042
Cdd:TIGR01517  877 FNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
75-906 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1324.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   75 LEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGnegcataqggaedegEAEAGWIEG 154
Cdd:cd02081    1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGEG---------------EGKTGWIEG 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  155 AAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDL 234
Cdd:cd02081   66 VAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDL 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  235 KIDESSLTGESDQVRKSVD---KDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGeeeekkdkkakqqdgaaa 311
Cdd:cd02081  145 KIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAEN------------------ 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  312 memqplksaeggdaddrkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWlpecTPVY 391
Cdd:cd02081  207 ------------------------EEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFIIDGFVNDGKSF----SAED 258
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  392 VQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYV 471
Cdd:cd02081  259 LQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTQNRMTVVQGYI 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  472 GdvhykeipdpssintktmellinaiainsayttkilppekegalprqvgNKTECGLLGFVLDLKQDYePVRSQMPEEKL 551
Cdd:cd02081  339 G-------------------------------------------------NKTECALLGFVLELGGDY-RYREKRPEEKV 368
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  552 YKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGEpRVFRPRDRDEMVKKVIEPMACDGLRTICVAY 631
Cdd:cd02081  369 LKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIKRVIEPMASDSLRTIGLAY 447
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  632 RDFPSSPEP----DWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGE 707
Cdd:cd02081  448 RDFSPDEEPtaerDWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGE 527
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  708 DFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSthteqRQVVAVTGDGTNDGPALKKAD 787
Cdd:cd02081  528 DGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEVVAVTGDGTNDAPALKKAD 602
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  788 VGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLW 867
Cdd:cd02081  603 VGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAFIGAVVTKDSPLTAVQMLW 682
                        810       820       830
                 ....*....|....*....|....*....|....*....
gi 48255949  868 VNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTM 906
Cdd:cd02081  683 VNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
52-1036 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 681.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVtliileiaaiisL--------GLSF 123
Cdd:COG0474   12 SAEEVLAELGTSE-EGL--SSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNP------------LilillaaaVISA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  124 yhppgegnegcATaqggaedeGEaeagWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVVRAGQVVQI 203
Cdd:COG0474   77 -----------LL--------GD----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAP--TARVLRDGKWVEI 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  204 PVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSV----------DKDPMLLSGTHVMEGSGRMLV 273
Cdd:COG0474  132 PAEELVPGDIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSAdplpedaplgDRGNMVFMGTLVTSGRGTAVV 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  274 TAVGVNSQTGIIftllgaggeeeekkdkkakqqdgaAAMemqpLKSAEggdaddrkkasmhkKEKSVLQGKLTKLAVQIG 353
Cdd:COG0474  212 VATGMNTEFGKI------------------------AKL----LQEAE--------------EEKTPLQKQLDRLGKLLA 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  354 KAGLVMSAITVIILVLYftvdtfvvnKKPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDN 433
Cdd:COG0474  250 IIALVLAALVFLIGLLR---------GGPLL------------EALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRN 308
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  434 NLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYkeipDPSSINTKTMELLINAIAINSAYTtkiLPPEKE 513
Cdd:COG0474  309 AIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY----EVTGEFDPALEELLRAAALCSDAQ---LEEETG 381
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  514 galprqVGNKTECGLLGFVLDLKQDYEPVRSQMPeekLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKI 593
Cdd:COG0474  382 ------LGDPTEGALLVAAAKAGLDVEELRKEYP---RVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEVVLALCTRV 452
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  594 LNGaGEPRVFRPRDRDEMVKKVIEpMACDGLRTICVAYRDFPSSPEPDwdnENDILNELTCICVVGIEDPVRPEVPEAIR 673
Cdd:COG0474  453 LTG-GGVVPLTEEDRAEILEAVEE-LAAQGLRVLAVAYKELPADPELD---SEDDESDLTFLGLVGMIDPPRPEAKEAIA 527
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  674 KCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDflCLEGKEFNRrirneKGEIE-QERIDKIwpklRVLARSSPTDKH 752
Cdd:COG0474  528 ECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA-----MSDEElAEAVEDV----DVFARVSPEHKL 596
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  753 TLVKGIidsthteQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSI 830
Cdd:COG0474  597 RIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNI 669
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  831 SKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNI 910
Cdd:COG0474  670 RKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRI 749
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  911 LGHAVYQLALIFTLLFVGekmfqIDSGRNAPLHSppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIFRNPIFCT 989
Cdd:COG0474  750 LLLGLLIAIFTLLTFALA-----LARGASLALAR------TMAFTTLVLSQLFNVFNCRSER--RSFFKsGLFPNRPLLL 816
                        970       980       990      1000
                 ....*....|....*....|....*....|....*....|....*....
gi 48255949  990 IVLGTFAIQIVIVQ--FGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVI 1036
Cdd:COG0474  817 AVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLILGLALLYLLLVELV 865
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
76-894 2.26e-159

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 490.97  E-value: 2.26e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   76 EKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLsfyhppgegnegcataqggaedegeaeAGWIEGA 155
Cdd:cd02089    8 ERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVL---------------------------GEYVDAI 60
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  156 AILLSVICVVLVTAFNDWSKEKQFRGLQSRieQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLK 235
Cdd:cd02089   61 VIIAIVILNAVLGFVQEYKAEKALAALKKM--SAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLIESASLR 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  236 IDESSLTGESDQVRKSVDKDP-----------MLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkak 304
Cdd:cd02089  139 VEESSLTGESEPVEKDADTLLeedvplgdrknMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEE------------- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  305 qqdgaaamemqplksaeggdaddrkkasmHKKEKSVLQGKLTKLAVQIGKAGLvmsAITVIILVLYftvdtfVVNKKPWL 384
Cdd:cd02089  206 -----------------------------TEEEKTPLQKRLDQLGKRLAIAAL---IICALVFALG------LLRGEDLL 247
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  385 PEctpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRM 464
Cdd:cd02089  248 DM------------LLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIRKLPAVETLGSVSVICSDKTGTLTQNKM 315
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  465 TVVQAYVgdvhykeIPDPSSIntktmellinAIaINSAYTTKILPPEKEGALPRQvgnktecgllgfvldlkqdyepvrS 544
Cdd:cd02089  316 TVEKIYT-------IGDPTET----------AL-IRAARKAGLDKEELEKKYPRI------------------------A 353
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  545 QMPeeklykvytFNSVRKSMSTVIKLPDEsFRMYSKGASEIVLKKCCKILNGaGEPRVFRPRDRDEmVKKVIEPMACDGL 624
Cdd:cd02089  354 EIP---------FDSERKLMTTVHKDAGK-YIVFTKGAPDVLLPRCTYIYIN-GQVRPLTEEDRAK-ILAVNEEFSEEAL 421
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  625 RTICVAYRDFPSSPEPDWDN-ENDilneLTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGII 703
Cdd:cd02089  422 RVLAVAYKPLDEDPTESSEDlEND----LIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKELGIL 497
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  704 HPGEdfLCLEGKEFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIidsthteQRQ--VVAVTGDGTNDGP 781
Cdd:cd02089  498 EDGD--KALTGEELD--------KMSDEELEKKVEQISVYARVSPEHKLRIVKAL-------QRKgkIVAMTGDGVNDAP 560
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  782 ALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLK 861
Cdd:cd02089  561 ALKAADIGVAMGITGTDVAKEAADMILTDDNFATIVAAVEEGRTIYDNIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLL 640
                        810       820       830
                 ....*....|....*....|....*....|...
gi 48255949  862 AVQMLWVNLIMDTFASLALATEPPTETLLLRKP 894
Cdd:cd02089  641 PIQLLWINLLTDGLPALALGVEPAEPDIMDRKP 673
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
157-880 1.51e-149

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 460.25  E-value: 1.51e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    157 ILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVvQIPVAEIVVGDIAQVKYGDLLPADGLFIQGnDLKI 236
Cdd:TIGR01494    2 ILFLVLLFVLLEVKQKLKAEDALRSLKDSLVNTATVLVLRNGWK-EISSKDLVPGDVVLVKSGDTVPADGVLLSG-SAFV 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    237 DESSLTGESDQVRKSVDKDP-MLLSGTHVMEGSGRMLVTAVGVNSQTGIIftllgaggeeeekkdkkakqqdgAAAMemq 315
Cdd:TIGR01494   80 DESSLTGESLPVLKTALPDGdAVFAGTINFGGTLIVKVTATGILTTVGKI-----------------------AVVV--- 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    316 plksaeggdaddrkKASMHkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFvvnkkpwlpectpvyvqYF 395
Cdd:TIGR01494  134 --------------YTGFS--TKTPLQSKADKFENFIFILFLLLLALAVFLLLPIGGWDGN-----------------SI 180
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    396 VKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVH 475
Cdd:TIGR01494  181 YKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNALEELGKVDVICFDKTGTLTTNKMTLQKVIIIGGV 260
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    476 YKEIPDPSSINtktmellinaiainsayttkilppekeGALPRQVGNKTECGLLGFV-LDLKQDYEPVrsqmpEEKLYKV 554
Cdd:TIGR01494  261 EEASLALALLA---------------------------ASLEYLSGHPLERAIVKSAeGVIKSDEINV-----EYKILDV 308
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    555 YTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNgageprvfrprdrdemVKKVIEPMACDGLRTICVAYRDF 634
Cdd:TIGR01494  309 FPFSSVLKRMGVIVEGANGSDLLFVKGAPEFVLERCNNEND----------------YDEKVDEYARQGLRVLAFASKKL 372
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    635 PsspepdwdnendilNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflcleg 714
Cdd:TIGR01494  373 P--------------DDLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKELGID----------- 427
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    715 kefnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKGIIDSTHTeqrqvVAVTGDGTNDGPALKKADVGFAMGI 794
Cdd:TIGR01494  428 ---------------------------VFARVKPEEKAAIVEALQEKGRT-----VAMTGDGVNDAPALKKADVGIAMGS 475
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    795 AgtDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACItqdsplkavqmlwvNLIMDT 874
Cdd:TIGR01494  476 G--DVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVI--------------ILLPPL 539

                   ....*.
gi 48255949    875 FASLAL 880
Cdd:TIGR01494  540 LAALAL 545
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
151-1027 4.27e-142

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 450.18  E-value: 4.27e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  151 WIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQkfTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:cd02080   56 WVDAIVIFGVVLINAIIGYIQEGKAEKALAAIKNMLSPEA--TVLRDGKKLTIDAEELVPGDIVLLEAGDKVPADLRLIE 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  231 GNDLKIDESSLTGESDQVRKSVDKDP----------MLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGaggeeeekkd 300
Cdd:cd02080  134 ARNLQIDESALTGESVPVEKQEGPLEedtplgdrknMAYSGTLVTAGSATGVVVATGADTEIGRINQLLA---------- 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  301 kkakqqdgaaamEMQPLKSAeggdaddrkkasmhkkeksvLQGKLTKLAVQIGKAGLVMSAITVIIlvlyftvdTFVVNK 380
Cdd:cd02080  204 ------------EVEQLATP--------------------LTRQIAKFSKALLIVILVLAALTFVF--------GLLRGD 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  381 KPWlpectpvyvqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT 460
Cdd:cd02080  244 YSL------------VELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIRRLPAVETLGSVTVICSDKTGTLT 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  461 TNRMTVVQAYvgdvhykeipdpssintktmeLLINAIAInsayttkilppEKEGALPRQVGNKTECGLLGFVLDLKQDYE 540
Cdd:cd02080  312 RNEMTVQAIV---------------------TLCNDAQL-----------HQEDGHWKITGDPTEGALLVLAAKAGLDPD 359
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  541 PVRSQMPEEKlykVYTFNSVRKSMSTVIKLPDESfRMYSKGASEIVLKKCCKILNGAGEprvfRPRDRDEMVKKViEPMA 620
Cdd:cd02080  360 RLASSYPRVD---KIPFDSAYRYMATLHRDDGQR-VIYVKGAPERLLDMCDQELLDGGV----SPLDRAYWEAEA-EDLA 430
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  621 CDGLRTICVAYRDFPssPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKC 700
Cdd:cd02080  431 KQGLRVLAFAYREVD--SEVEEIDHADLEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQL 508
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  701 GIIHPGEdflCLEGKEFNRRIRNEKGEIEQERidkiwpklRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDG 780
Cdd:cd02080  509 GLGDGKK---VLTGAELDALDDEELAEAVDEV--------DVFARTSPEHKLRLVRAL-----QARGEVVAMTGDGVNDA 572
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  781 PALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV---VAVIVA-FTGACItq 856
Cdd:cd02080  573 PALKQADIGIAMGIKGTEVAKEAADMVLADDNFATIAAAVEEGRRVYDNLKKFILFTLPTNLgegLVIIVAiLFGVTL-- 650
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  857 dsPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTL-LFVGEKMFQID 935
Cdd:cd02080  651 --PLTPVQILWINMVTAITLGLALAFEPAEPGIMKRPPRDPSEPLLSRELIWRILLVSLLMLGGAFGLfLWALDRGYSLE 728
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  936 SGRnaplhsppsehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCS 1012
Cdd:cd02080  729 TAR------------TMAVNTIVVAQIFYLFNCRSLH--RSILKlGVFSNKILFLGIGALILLQLAFTYlpFMNSLFGTA 794
                        890
                 ....*....|....*
gi 48255949 1013 PLQLDQWMWCIFIGL 1027
Cdd:cd02080  795 PIDLVDWAIILLVGI 809
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
52-903 6.54e-132

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 427.86  E-value: 6.54e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   52 DTEAICRRLKTSPVEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYhppgegn 131
Cdd:cd02083    4 TVEEVLAYFGVDPTRGL--SDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALF------- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  132 egcataqggaEDEGEAEAGWIEGAAILLSVIC--VVLVtafndWskekQFRGLQSRIEQEQKF-----TVVRAGQVVQ-I 203
Cdd:cd02083   75 ----------EEGEEGVTAFVEPFVILLILIAnaVVGV-----W----QERNAEKAIEALKEYepemaKVLRNGKGVQrI 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  204 PVAEIVVGDIAQVKYGDLLPADG--LFIQGNDLKIDESSLTGESDQVRKSVD--KDP---------MLLSGTHVMEGSGR 270
Cdd:cd02083  136 RARELVPGDIVEVAVGDKVPADIriIEIKSTTLRVDQSILTGESVSVIKHTDvvPDPravnqdkknMLFSGTNVAAGKAR 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  271 MLVTAVGVNSQTGIIftllgaggeeeekkdkkakqQDGAAAMEmqplksaeggdaddrkkasmhkKEKSVLQGKLTKLAV 350
Cdd:cd02083  216 GVVVGTGLNTEIGKI--------------------RDEMAETE----------------------EEKTPLQQKLDEFGE 253
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  351 QIGKAglvmsaITVI-ILVlyftvdtFVVNKKPWlpeCTPVYVQYFVK----FFIIGVTVLVVAVPEGLPLAVTISLAYS 425
Cdd:cd02083  254 QLSKV------ISVIcVAV-------WAINIGHF---NDPAHGGSWIKgaiyYFKIAVALAVAAIPEGLPAVITTCLALG 317
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  426 VKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYV-----GDVHYKEIP--------------DPSSIN 486
Cdd:cd02083  318 TRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIldkveDDSSLNEFEvtgstyapegevfkNGKKVK 397
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  487 TKTMELLINAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFV------------LDLKQDYEPVRSQMpEEKLYKV 554
Cdd:cd02083  398 AGQYDGLVELATICALCNDSSLDYNESKGVYEKVGEATETALTVLVekmnvfntdksgLSKRERANACNDVI-EQLWKKE 476
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  555 YT--FNSVRKSMSTVIKLPDESF--RMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEpMACDGLRTICVA 630
Cdd:cd02083  477 FTleFSRDRKSMSVYCSPTKASGgnKLFVKGAPEGVLERCTHVRVGGGKVVPLTAAIKILILKKVWG-YGTDTLRCLALA 555
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  631 YRDFPSSPEP----DWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPG 706
Cdd:cd02083  556 TKDTPPKPEDmdleDSTKFYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGED 635
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  707 EDFlclEGKEFNRRIRNEKGEIEQEridKIWPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKA 786
Cdd:cd02083  636 EDT---TGKSYTGREFDDLSPEEQR---EACRRARLFSRVEPSHKSKIVELL-----QSQGEITAMTGDGVNDAPALKKA 704
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  787 DVGFAMGIaGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQML 866
Cdd:cd02083  705 EIGIAMGS-GTAVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLL 783
                        890       900       910
                 ....*....|....*....|....*....|....*..
gi 48255949  867 WVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLIS 903
Cdd:cd02083  784 WVNLVTDGLPATALGFNPPDLDIMKKPPRKPDEPLIS 820
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
142-1027 1.56e-126

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 411.48  E-value: 1.56e-126
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    142 EDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSrIEQEQKfTVVRAGQVVQIPVAEIVVGDIAQVKYGDL 221
Cdd:TIGR01116   27 EEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKAIEALKE-YESEHA-KVLRDGRWSVIKAKDLVPGDIVELAVGDK 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    222 LPADGLFIQGNDLKIDESSLTGESDQVRKSV-----------DKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIftllg 290
Cdd:TIGR01116  105 VPADIRVLSLKTLRVDQSILTGESVSVNKHTesvpderavnqDKKNMLFSGTLVVAGKARGVVVRTGMSTEIGKI----- 179
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    291 aggeeeekkdkkakqqdgaaamemqplksaeggdaddRKKASMHKKEKSVLQGKLTKLAVQIGKaglVMSAITVIIlvly 370
Cdd:TIGR01116  180 -------------------------------------RDEMRAAEQEDTPLQKKLDEFGELLSK---VIGLICILV---- 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    371 ftvdtFVVNKKPWLPECTPV-YVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNAT 449
Cdd:TIGR01116  216 -----WVINIGHFNDPALGGgWIQGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTT 290
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    450 AICSDKTGTLTTNRMTVV----------QAYVGDVH----------YKEIPDPSSINTKTMELLINAIAINSayTTKILP 509
Cdd:TIGR01116  291 VICSDKTGTLTTNQMSVCkvvaldpsssSLNEFCVTgttyapeggvIKDDGPVAGGQDAGLEELATIAALCN--DSSLDF 368
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    510 PEKEGALPRqVGNKTECGLLGFV--LDLKQDYEPVRS---------QMPEEKLYKVYT--FNSVRKSMSTVIKlPDESFR 576
Cdd:TIGR01116  369 NERKGVYEK-VGEATEAALKVLVekMGLPATKNGVSSkrrpalgcnSVWNDKFKKLATleFSRDRKSMSVLCK-PSTGNK 446
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    577 MYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPE----PDWDNENDILNEL 652
Cdd:TIGR01116  447 LFVKGAPEGVLERCTHILNGDGRAVPLTDKMKNTILSVIKEMGTTKALRCLALAFKDIPDPREedllSDPANFEAIESDL 526
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    653 TCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGED--FLCLEGKEFNrrirnekgEIEQ 730
Cdd:TIGR01116  527 TFIGVVGMLDPPRPEVADAIEKCRTAGIRVIMITGDNKETAEAICRRIGIFSPDEDvtFKSFTGREFD--------EMGP 598
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    731 ERIDKIWPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTD 810
Cdd:TIGR01116  599 AKQRAACRSAVLFSRVEPSHKSELVELL-----QEQGEIVAMTGDGVNDAPALKKADIGIAMG-SGTEVAKEASDMVLAD 672
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    811 DNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLL 890
Cdd:TIGR01116  673 DNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGEVVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIM 752
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    891 LRKPYGRNKPLIS-----RTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSGRNAP--------LHSPPSEHYTIIFNTF 957
Cdd:TIGR01116  753 WKPPRRPDEPLITgwlffRYLVVGVYVGLATVGGFVWWYLLTHFTGCDEDSFTTCPdfedpdcyVFEGKQPARTISLSVL 832
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48255949    958 VMMQLFNEINARKIHGERNVFdGIFRNPIFCTIVLGTFAIQIVI--VQFGGKPFSCSPLQLDQWMWCIFIGL 1027
Cdd:TIGR01116  833 VVIEMFNALNALSEDQSLLRM-PPWVNKWLIGAICLSMALHFLIlyVPFLSRIFGVTPLSLTDWLMVLKLSL 903
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
151-1001 1.59e-124

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 406.46  E-value: 1.59e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  151 WIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKftVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:cd02086   56 WIEGGVIAAVIALNVIVGFIQEYKAEKTMDSLRNLSSPNAH--VIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIE 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  231 GNDLKIDESSLTGESDQVRKSV-------------DKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeee 297
Cdd:cd02086  134 TKNFETDEALLTGESLPVIKDAelvfgkeedvsvgDRLNLAYSSSTVTKGRAKGIVVATGMNTEIGKIAKAL-------- 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  298 kkdkkakqQDGAAAMEMQPLKSAEGGDADDRKKASMH---KKEKSVLQGKLTKLAVqigkaglVMSAITVIILVLYFTVD 374
Cdd:cd02086  206 --------RGKGGLISRDRVKSWLYGTLIVTWDAVGRflgTNVGTPLQRKLSKLAY-------LLFFIAVILAIIVFAVN 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  375 TFVVNKKpwlpectpvyvqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSD 454
Cdd:cd02086  271 KFDVDNE----------------VIIYAIALAISMIPESLVAVLTITMAVGAKRMVKRNVIVRKLDALEALGAVTDICSD 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  455 KTGTLTTNRMTVVQAYVgdvhykeipdPSSintktmelLINAIAINSAyttkilppeKEGALPRQVGNKTECGLLGFV-- 532
Cdd:cd02086  335 KTGTLTQGKMVVRQVWI----------PAA--------LCNIATVFKD---------EETDCWKAHGDPTEIALQVFAtk 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  533 LDLKQDYEPVRSQmPEEKLYKVYTFNSVRKSMSTVI--KLPDESFrMYSKGASEIVLKkCCKILNGAGEPRVFRPRDRDE 610
Cdd:cd02086  388 FDMGKNALTKGGS-AQFQHVAEFPFDSTVKRMSVVYynNQAGDYY-AYMKGAVERVLE-CCSSMYGKDGIIPLDDEFRKT 464
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  611 MVKKViEPMACDGLRTICVAYRDF-------PSSPEPDWDNEnDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVR 683
Cdd:cd02086  465 IIKNV-ESLASQGLRVLAFASRSFtkaqfndDQLKNITLSRA-DAESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVH 542
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  684 MVTGDNINTARAIAIKCGIIHPGE--------DFLCLEGKEFNRrirnekgeIEQERIDKIwPKL-RVLARSSPTDKhtl 754
Cdd:cd02086  543 MLTGDHPGTAKAIAREVGILPPNSyhysqeimDSMVMTASQFDG--------LSDEEVDAL-PVLpLVIARCSPQTK--- 610
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  755 VKgIIDSTHTEQRqVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFL 834
Cdd:cd02086  611 VR-MIEALHRRKK-FCAMTGDGVNDSPSLKMADVGIAMGLNGSDVAKDASDIVLTDDNFASIVNAIEEGRRMFDNIQKFV 688
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  835 QFQLTVNVVAVIVAFTGACITQDS-----PLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKN 909
Cdd:cd02086  689 LHLLAENVAQVILLLIGLAFKDEDglsvfPLSPVEILWINMVTSSFPAMGLGLEKASPDVMQRPPHDLKVGIFTRELIID 768
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  910 ILghaVYQLALIFTLL--FVGeKMFQIDSGRnapLHSPPSEHYTI-----------IFNTFVMMQLF---NEINARK--- 970
Cdd:cd02086  769 TF---VYGTFMGVLCLasFTL-VIYGIGNGD---LGSDCNESYNSscedvfraraaVFATLTWCALIlawEVVDMRRsff 841
                        890       900       910
                 ....*....|....*....|....*....|....*...
gi 48255949  971 -IHGE-----RNVFDGIFRNP-IFCTIVLGTFAIQIVI 1001
Cdd:cd02086  842 nMHPDtdspvKSFFKTLWKNKfLFWSVVLGFVSVFPTL 879
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
156-1015 2.77e-119

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 388.68  E-value: 2.77e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  156 AILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEqkFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLK 235
Cdd:cd02085   52 SITVAILIVVTVAFVQEYRSEKSLEALNKLVPPE--CHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLS 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  236 IDESSLTGESDQVRKSVD-------KDPMLLS-----GTHVMEGSGRMLVTAVGVNSQTGIIFtllgaggeeeekkdkka 303
Cdd:cd02085  130 IDESSLTGETEPCSKTTEvipkasnGDLTTRSniafmGTLVRCGHGKGIVIGTGENSEFGEVF----------------- 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  304 kqqdgaaamEMqplksaeggdaddrkkasMHKKE--KSVLQGKLTKLAVQigkaglvMSAITVIILVLYFTVDTFvvNKK 381
Cdd:cd02085  193 ---------KM------------------MQAEEapKTPLQKSMDKLGKQ-------LSLYSFIIIGVIMLIGWL--QGK 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  382 PWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTT 461
Cdd:cd02085  237 NLL------------EMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTK 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  462 NRMTVVQAYVGDVhykeipdpssintktmellinaiaINSAYTTKILPPekegalprqvGNKTECGLLgfVLDLKQDYEP 541
Cdd:cd02085  305 NEMTVTKIVTGCV------------------------CNNAVIRNNTLM----------GQPTEGALI--ALAMKMGLSD 348
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  542 VRSqmpEEKLYKVYTFNSVRKSMSTVIKLPDESFR---MYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEmVKKVIEP 618
Cdd:cd02085  349 IRE---TYIRKQEIPFSSEQKWMAVKCIPKYNSDNeeiYFMKGALEQVLDYCTTYNSSDGSALPLTQQQRSE-INEEEKE 424
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  619 MACDGLRTICVAyrdfpSSPEpdwdnendiLNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAI 698
Cdd:cd02085  425 MGSKGLRVLALA-----SGPE---------LGDLTFLGLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGS 490
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  699 KCGIIHPGEdfLCLEGKEFNRrirnekgeIEQERIDKIWPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTN 778
Cdd:cd02085  491 SLGLYSPSL--QALSGEEVDQ--------MSDSQLASVVRKVTVFYRASPRHKLKIVKAL-----QKSGAVVAMTGDGVN 555
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  779 DGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS 858
Cdd:cd02085  556 DAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPN 635
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  859 PLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAvyqlALIFT-LLFVGEKmfQIDSG 937
Cdd:cd02085  636 PLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPRNVKDPILTRSLILNVLLSA----AIIVSgTLWVFWK--EMSDD 709
                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 48255949  938 RNAPLHSppsehyTIIFNTFVMMQLFNEINARkiHGERNVFD-GIFRNPIFCTIVLGTFAIQIVIVQFggkpfscSPLQ 1015
Cdd:cd02085  710 NVTPRDT------TMTFTCFVFFDMFNALSCR--SQTKSIFEiGFFSNRMFLYAVGGSLIGQLLVIYF-------PPLQ 773
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
451-880 9.36e-97

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 311.31  E-value: 9.36e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  451 ICSDKTGTLTTNRMTVVqayvgDVHYKEIPdpssintktmellinaiainsayttkilppekegalprqvgnktecgllg 530
Cdd:cd01431    2 ICSDKTGTLTKNGMTVT-----KLFIEEIP-------------------------------------------------- 26
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  531 fvldlkqdyepvrsqmpeeklykvytFNSVRKSMSTVIKLPDEsFRMYSKGASEIVLKKCCKILngageprvfrPRDRDE 610
Cdd:cd01431   27 --------------------------FNSTRKRMSVVVRLPGR-YRAIVKGAPETILSRCSHAL----------TEEDRN 69
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  611 MVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENdilneLTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNI 690
Cdd:cd01431   70 KIEKAQEESAREGLRVLALAYREFDPETSKEAVELN-----LVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNP 144
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  691 NTARAIAIKCGIIHPGEDFLCLEgkefnrrirnEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHteqrqVV 770
Cdd:cd01431  145 LTAIAIAREIGIDTKASGVILGE----------EADEMSEEELLDLIAKVAVFARVTPEQKLRIVKALQARGE-----VV 209
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  771 AVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFT 850
Cdd:cd01431  210 AMTGDGVNDAPALKQADVGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIAL 289
                        410       420       430
                 ....*....|....*....|....*....|
gi 48255949  851 GACITQDSPLKAVQMLWVNLIMDTFASLAL 880
Cdd:cd01431  290 ALFLGGPLPLLAFQILWINLVTDLIPALAL 319
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
155-883 2.67e-96

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 321.29  E-value: 2.67e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  155 AAILLSVICV-VLVTAFNDWSKEKQFRGLqsRIEQEQKFTVVRA--GQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQG 231
Cdd:cd07539   60 AVLIVGVLTVnAVIGGVQRLRAERALAAL--LAQQQQPARVVRApaGRTQTVPAESLVPGDVIELRAGEVVPADARLLEA 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  232 NDLKIDESSLTGESDQVRKSVDKDP---------MLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGaggeeeekkdkk 302
Cdd:cd07539  138 DDLEVDESALTGESLPVDKQVAPTPgapladracMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVA------------ 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  303 akqqdgaaamemqPLKSAEGgdaddrkkasmhkkeksvLQGKLTKLAVQigkaglvMSAITVIILVLYFTVDtfVVNKKP 382
Cdd:cd07539  206 -------------PVETATG------------------VQAQLRELTSQ-------LLPLSLGGGAAVTGLG--LLRGAP 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  383 WLPectpvyvqyFVKffiIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTN 462
Cdd:cd07539  246 LRQ---------AVA---DGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDKTGTLTEN 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  463 RMTVVQayvgdvhykeipdpssintktmellinaiainsayttkILPPEKEgaLPrqvgnktecgllgfvldlkqdyepv 542
Cdd:cd07539  314 RLRVVQ--------------------------------------VRPPLAE--LP------------------------- 328
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  543 rsqmpeeklykvytFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGePRVFRPRDRDeMVKKVIEPMACD 622
Cdd:cd07539  329 --------------FESSRGYAAAIGRTGGGIPLLAVKGAPEVVLPRCDRRMTGGQ-VVPLTEADRQ-AIEEVNELLAGQ 392
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  623 GLRTICVAYRDFPSSPEPDWDNENDilnELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGI 702
Cdd:cd07539  393 GLRVLAVAYRTLDAGTTHAVEAVVD---DLELLGLLGLADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGL 469
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  703 ihpGEDFLCLEGKEFNRrirnekgeIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGDGTNDGPA 782
Cdd:cd07539  470 ---PRDAEVVTGAELDA--------LDEEALTGLVADIDVFARVSPEQKLQIVQALQAAGR-----VVAMTGDGANDAAA 533
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  783 LKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKA 862
Cdd:cd07539  534 IRAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRDAVHVLLGGNLGEVMFTLIGTAIGGGAPLNT 613
                        730       740
                 ....*....|....*....|.
gi 48255949  863 VQMLWVNLIMDTFASLALATE 883
Cdd:cd07539  614 RQLLLVNLLTDMFPALALAVE 634
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
156-927 6.92e-93

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 318.91  E-value: 6.92e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  156 AILLSVicVVLVTAFNDWSKEKQfrglQSRIEQE------QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFI 229
Cdd:cd02608   72 GIVLAA--VVIVTGCFSYYQEAK----SSKIMDSfknmvpQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRII 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  230 QGNDLKIDESSLTGESDQVRKSVD---KDPM------LLSgTHVMEGSGRMLVTAVGVNSQTGIIFTLlgaggeeeekkd 300
Cdd:cd02608  146 SAHGCKVDNSSLTGESEPQTRSPEfthENPLetkniaFFS-TNCVEGTARGIVINTGDRTVMGRIATL------------ 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  301 kkakqqdgAAAMEMQPlksaeggdaddrkkasmhkkeksvlqgklTKLAVQIGKAGLVMSAITVIILVLYFTVDtfVVNK 380
Cdd:cd02608  213 --------ASGLEVGK-----------------------------TPIAREIEHFIHIITGVAVFLGVSFFILS--LILG 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  381 KPWLPECtpvyvqyfvkFFIIGVtvlVVA-VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTL 459
Cdd:cd02608  254 YTWLEAV----------IFLIGI---IVAnVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTL 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  460 TTNRMTVVQA-YVGDVHYKEIPDPSSINTKT------MELLINAIAINSAyttKILPPEKEGALPRQV--GNKTECGLLG 530
Cdd:cd02608  321 TQNRMTVAHMwFDNQIHEADTTEDQSGASFDkssatwLALSRIAGLCNRA---EFKAGQENVPILKRDvnGDASESALLK 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  531 FVLDLKQDYEPVRSQMPeeKLYKVyTFNSVRK---SMSTVIKLPDESFRMYSKGASEIVLKKCCKIL-NGAGEPrvfrpr 606
Cdd:cd02608  398 CIELSCGSVMEMRERNP--KVAEI-PFNSTNKyqlSIHENEDPGDPRYLLVMKGAPERILDRCSTILiNGKEQP------ 468
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  607 dRDEMVKKVIEP--MACDGL--RTI--CVAY---RDFPSSPEPDWDNENDILNELtciCVVGIE---DPVRPEVPEAIRK 674
Cdd:cd02608  469 -LDEEMKEAFQNayLELGGLgeRVLgfCHLYlpdDKFPEGFKFDTDEVNFPTENL---CFVGLMsmiDPPRAAVPDAVGK 544
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  675 CQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridkiwpklrVLARSSPTDKHTL 754
Cdd:cd02608  545 CRSAGIKVIMVTGDHPITAKAIAKGVGII--------------------------------------VFARTSPQQKLII 586
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  755 VKGIidsthteQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISK 832
Cdd:cd02608  587 VEGC-------QRQgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK 659
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  833 FLQFQLTVNvVAVIVAFTgACITQDSPLK--AVQMLWVNLIMDTFASLALATEPPTETLLLRKPygRNkPLISRTMMKNI 910
Cdd:cd02608  660 SIAYTLTSN-IPEITPFL-IFIIANIPLPlgTITILCIDLGTDMVPAISLAYEKAESDIMKRQP--RN-PKTDKLVNERL 734
                        810       820
                 ....*....|....*....|..
gi 48255949  911 LGHAVYQLALI-----FTLLFV 927
Cdd:cd02608  735 ISMAYGQIGMIqalagFFTYFV 756
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
71-917 1.92e-92

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 311.30  E-value: 1.92e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   71 TAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLsfyhppgegnegcataqggaedeGEAEag 150
Cdd:cd07538    3 TEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVL-----------------------GDPR-- 57
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  151 wiEGAAILLSVICVVLVTAFNDWSKEKQFRGLqsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:cd07538   58 --EGLILLIFVVVIIAIEVVQEWRTERALEAL--KNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLE 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  231 GNDLKIDESSLTGESDQVRKSVD----------KDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIftllgaggeeeekkd 300
Cdd:cd07538  134 NDDLGVDESTLTGESVPVWKRIDgkamsapggwDKNFCYAGTLVVRGRGVAKVEATGSRTELGKI--------------- 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  301 kkakqqdGAAAMEMQplksaeggdaddrkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIIlvlyftvdtFVVNK 380
Cdd:cd07538  199 -------GKSLAEMD--------------------DEPTPLQKQTGRLVKLCALAALVFCALIVAV---------YGVTR 242
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  381 KPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT 460
Cdd:cd07538  243 GDWI------------QAILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSITVLCVDKTGTLT 310
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  461 TNRMTVVQAYVgdvhykeipdpssintktmellinaiainsayttkilppekegalprqvgnktecgllgfvldlkqdye 540
Cdd:cd07538  311 KNQMEVVELTS--------------------------------------------------------------------- 321
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  541 PVRSqmpeeklykvYTFNSVRKSMSTVIKLPDESFrMYSKGASEIVLKKCckilngageprVFRPRDRDEMVKKVIEpMA 620
Cdd:cd07538  322 LVRE----------YPLRPELRMMGQVWKRPEGAF-AAAKGSPEAIIRLC-----------RLNPDEKAAIEDAVSE-MA 378
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  621 CDGLRTICVAyrdfpsSPEPDWDNENDILNELTCICV--VGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAI 698
Cdd:cd07538  379 GEGLRVLAVA------ACRIDESFLPDDLEDAVFIFVglIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAK 452
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  699 KCGIIH-----PGEDFLCLEGKEFNRRIRNekgeieqeridkiwpkLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVT 773
Cdd:cd07538  453 QIGLDNtdnviTGQELDAMSDEELAEKVRD----------------VNIFARVVPEQKLRIVQAF-----KANGEIVAMT 511
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  774 GDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGAC 853
Cdd:cd07538  512 GDGVNDAPALKAAHIGIAMGKRGTDVAREASDIVLLDDNFSSIVSTIRLGRRIYDNLKKAITYVFAIHVPIAGLALLPPL 591
                        810       820       830       840       850       860
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 48255949  854 ITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISrtmmKNILGHAVYQ 917
Cdd:cd07538  592 LGLPPLLFPVHVVLLELIIDPTCSIVFEAEPAERDIMRRPPRPPDEPLFG----PRLVIKAILQ 651
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
190-920 4.71e-88

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 307.49  E-value: 4.71e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    190 QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVD---KDPM-----LLSG 261
Cdd:TIGR01106  141 QQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEfthENPLetrniAFFS 220
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    262 THVMEGSGRMLVTAVGVNSQTGIIFTLlgaggeeeekkdkkakqqdgaaamemqplksAEGgdaddrkkasmhkkeksvL 341
Cdd:TIGR01106  221 TNCVEGTARGIVVNTGDRTVMGRIASL-------------------------------ASG------------------L 251
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    342 QGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDtfVVNKKPWLPECtpvyvqyfvkFFIIGVtvLVVAVPEGLPLAVTIS 421
Cdd:TIGR01106  252 ENGKTPIAIEIEHFIHIITGVAVFLGVSFFILS--LILGYTWLEAV----------IFLIGI--IVANVPEGLLATVTVC 317
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    422 LAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVV------QAYVGDV---HYKEIPDPSSINTKTMEL 492
Cdd:TIGR01106  318 LTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAhmwfdnQIHEADTtedQSGVSFDKSSATWLALSR 397
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    493 LinAIAINSAyttkILPPEKEGA--LPRQV-GNKTECGLLGFVLDLKQDYEPVRSQMPeeKLYKVyTFNSVRKSMSTVIK 569
Cdd:TIGR01106  398 I--AGLCNRA----VFKAGQENVpiLKRAVaGDASESALLKCIELCLGSVMEMRERNP--KVVEI-PFNSTNKYQLSIHE 468
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    570 LPDES---FRMYSKGASEIVLKKCCKIL-NGAGEPRvfrprdrDEMVKKVIEP--MACDGL--RTI--CVAY---RDFPS 636
Cdd:TIGR01106  469 NEDPRdprHLLVMKGAPERILERCSSILiHGKEQPL-------DEELKEAFQNayLELGGLgeRVLgfCHLYlpdEQFPE 541
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    637 SPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPG----EDF--- 709
Cdd:TIGR01106  542 GFQFDTDDVNFPTDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGnetvEDIaar 621
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    710 LCLEGKEFNRRIRN-------EKGEIEQERIDKIwpkLR-----VLARSSPTDKHTLVKGIidsthteQRQ--VVAVTGD 775
Cdd:TIGR01106  622 LNIPVSQVNPRDAKacvvhgsDLKDMTSEQLDEI---LKyhteiVFARTSPQQKLIIVEGC-------QRQgaIVAVTGD 691
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    776 GTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV--VAVIVAFTGAC 853
Cdd:TIGR01106  692 GVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIpeITPFLIFIIAN 771
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 48255949    854 ITQdsPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGR------NKPLISRT-----MMKNILGHAVYQLAL 920
Cdd:TIGR01106  772 IPL--PLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPktdklvNERLISMAygqigMIQALGGFFTYFVIL 847
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
151-938 5.54e-84

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 296.54  E-value: 5.54e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    151 WIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKftVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:TIGR01523   81 WIEGGVISAIIALNILIGFIQEYKAEKTMDSLKNLASPMAH--VIRNGKSDAIDSHDLVPGDICLLKTGDTIPADLRLIE 158
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    231 GNDLKIDESSLTGESDQVRKSV-------------DKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeee 297
Cdd:TIGR01523  159 TKNFDTDEALLTGESLPVIKDAhatfgkeedtpigDRINLAFSSSAVTKGRAKGICIATALNSEIGAIAAGL-------- 230
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    298 kkdkkakQQDGAAamemqpLKSAEGGDADDRKKASMH--KKEKSV------------LQGKLTKLAVqigkaglVMSAIT 363
Cdd:TIGR01523  231 -------QGDGGL------FQRPEKDDPNKRRKLNKWilKVTKKVtgaflglnvgtpLHRKLSKLAV-------ILFCIA 290
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    364 VIILVLYFTVDTFVVNKKpwlpectpvyvqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACE 443
Cdd:TIGR01523  291 IIFAIIVMAAHKFDVDKE----------------VAIYAICLAISIIPESLIAVLSITMAMGAANMSKRNVIVRKLDALE 354
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    444 TMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEI---PDPSSINTKTMELLIN----AIAINSAYTTKILPPEK---- 512
Cdd:TIGR01523  355 ALGAVNDICSDKTGTITQGKMIARQIWIPRFGTISIdnsDDAFNPNEGNVSGIPRfspyEYSHNEAADQDILKEFKdelk 434
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    513 EGALPRQV--------------------------------GNKTECGLlgFVLDLKQDYePVRSQMPEEKLYKV------ 554
Cdd:TIGR01523  435 EIDLPEDIdmdlfiklletaalaniatvfkddatdcwkahGDPTEIAI--HVFAKKFDL-PHNALTGEEDLLKSnendqs 511
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    555 -------------------YTFNSVRKSMSTVIK-LPDESFRMYSKGASEIVLKkCCKILNGAGEPRVFRPRDRD-EMVK 613
Cdd:TIGR01523  512 slsqhnekpgsaqfefiaeFPFDSEIKRMASIYEdNHGETYNIYAKGAFERIIE-CCSSSNGKDGVKISPLEDCDrELII 590
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    614 KVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDILN------ELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTG 687
Cdd:TIGR01523  591 ANMESLAAEGLRVLAFASKSFDKADNNDDQLKNETLNrataesDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTG 670
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    688 DNINTARAIAIKCGII--------HPGEDFLCLEGKEFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKhtlVKgII 759
Cdd:TIGR01523  671 DFPETAKAIAQEVGIIppnfihdrDEIMDSMVMTGSQFD--------ALSDEEVDDLKALCLVIARCAPQTK---VK-MI 738
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    760 DSTHtEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLT 839
Cdd:TIGR01523  739 EALH-RRKAFCAMTGDGVNDSPSLKMANVGIAMGINGSDVAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLA 817
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    840 VNVVAVIVAFTGACITQDS-----PLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHA 914
Cdd:TIGR01523  818 ENVAEAILLIIGLAFRDENgksvfPLSPVEILWCIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVGIFQKELIIDMFAYG 897
                          890       900
                   ....*....|....*....|....
gi 48255949    915 VYqLALIFTLLFVGeKMFQIDSGR 938
Cdd:TIGR01523  898 FF-LGGSCLASFTG-ILYGFGSGN 919
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
152-888 3.81e-74

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 262.93  E-value: 3.81e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  152 IEGAAIL---------LSVICVVLVT-AFNDWSKEKQFRGLQSRIEQ--EQKFTVVRAGQVVQIPVAEIVVGDIAQVKYG 219
Cdd:cd02076   42 LEAAAILaaalgdwvdFAIILLLLLInAGIGFIEERQAGNAVAALKKslAPKARVLRDGQWQEIDAKELVPGDIVSLKIG 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  220 DLLPADGLFIQGNDLKIDESSLTGESDQVRKSvdKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGaggeeeekk 299
Cdd:cd02076  122 DIVPADARLLTGDALQVDQSALTGESLPVTKH--PGDEAYSGSIVKQGEMLAVVTATGSNTFFGKTAALVA--------- 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  300 dkkakqqdgaaamemqplkSAEGgdaddrkkasmhkkeksvlQGKLTKLAVQIGKAGLVMSAITV--IILVLYFTVDTFV 377
Cdd:cd02076  191 -------------------SAEE-------------------QGHLQKVLNKIGNFLILLALILVliIVIVALYRHDPFL 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  378 vnkkpwlpectpvyvqYFVKFFIIgvtVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTG 457
Cdd:cd02076  233 ----------------EILQFVLV---LLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAGVDILCSDKTG 293
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  458 TLTTNRMTVVQAYVGDVHYKEipdpssintktmELLINAiainsAYTTKilpPEKEGALPRQVgnktecglLGFVldlkQ 537
Cdd:cd02076  294 TLTLNKLSLDEPYSLEGDGKD------------ELLLLA-----ALASD---TENPDAIDTAI--------LNAL----D 341
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  538 DYEPVRSQMPEEKLYKvytFNSVRK-SMSTVIKLPDESFRmYSKGASEIVLKKCCKilngageprvfrPRDRDEMVKKVI 616
Cdd:cd02076  342 DYKPDLAGYKQLKFTP---FDPVDKrTEATVEDPDGERFK-VTKGAPQVILELVGN------------DEAIRQAVEEKI 405
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  617 EPMACDGLRTICVAYRDfpssPEPDWDnendILNELTCIcvvgieDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAI 696
Cdd:cd02076  406 DELASRGYRSLGVARKE----DGGRWE----LLGLLPLF------DPPRPDSKATIARAKELGVRVKMITGDQLAIAKET 471
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  697 AIKCGI---IHPGEDFLCLEGKefnrriRNEKGEIEQERIDKiwpkLRVLARSSPTDKHTLVKGIIDSTHteqrqVVAVT 773
Cdd:cd02076  472 ARQLGMgtnILSAERLKLGGGG------GGMPGSELIEFIED----ADGFAEVFPEHKYRIVEALQQRGH-----LVGMT 536
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  774 GDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVnVVAVIVAFTGAC 853
Cdd:cd02076  537 GDGVNDAPALKKADVGIAVSGA-TDAARAAADIVLTAPGLSVIIDAIKTSRQIFQRMKSYVIYRIAE-TLRILVFFTLGI 614
                        730       740       750
                 ....*....|....*....|....*....|....*..
gi 48255949  854 ITQDSPLKAVQMLWVNLIMDTFASLALATE--PPTET 888
Cdd:cd02076  615 LILNFYPLPLIMIVLIAILNDGATLTIAYDnvPPSPR 651
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
71-882 8.15e-70

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 250.24  E-value: 8.15e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   71 TAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNegcataqggaedegeaeag 150
Cdd:cd02077    3 TNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFD------------------- 63
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  151 wIEGAAILLS-VICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVVRAGQVVQ-IPVAEIVVGDIAQVKYGDLLPADGLF 228
Cdd:cd02077   64 -LVGALIILLmVLISGLLDFIQEIRSLKAAEKLKKMVKN--TATVIRDGSKYMeIPIDELVPGDIVYLSAGDMIPADVRI 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  229 IQGNDLKIDESSLTGESDQVRKSV-----------DKDPMLLSGTHVMEGSGRMLVTAVGVNsqtgiifTLLGaggeeee 297
Cdd:cd02077  141 IQSKDLFVSQSSLTGESEPVEKHAtakktkdesilELENICFMGTNVVSGSALAVVIATGND-------TYFG------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  298 kkdkkakqqdgaaamemqplkSAEGGDADDRKKASMHKKEKSVlqgklTKLavqigkaglvmsaITVIILVLYFTVdtFV 377
Cdd:cd02077  207 ---------------------SIAKSITEKRPETSFDKGINKV-----SKL-------------LIRFMLVMVPVV--FL 245
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  378 VN---KKPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSD 454
Cdd:cd02077  246 INgltKGDWL------------EALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNAIQNFGAMDILCTD 313
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  455 KTGTLTTNRMTVVQAYvgdvhykeipdpsSINTKTMELLINAIAINSAYTTKILPPeKEGALPRQVGNKTECGLlgfvld 534
Cdd:cd02077  314 KTGTLTQDKIVLERHL-------------DVNGKESERVLRLAYLNSYFQTGLKNL-LDKAIIDHAEEANANGL------ 373
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  535 lKQDYEPVrSQMPeeklykvytFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKI-LNGAGEPRVFRPRdrdEMVK 613
Cdd:cd02077  374 -IQDYTKI-DEIP---------FDFERRRMSVVVKDNDGKHLLITKGAVEEILNVCTHVeVNGEVVPLTDTLR---EKIL 439
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  614 KVIEPMACDGLRTICVAYRDFPSspePDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTA 693
Cdd:cd02077  440 AQVEELNREGLRVLAIAYKKLPA---PEGEYSVKDEKELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVT 516
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  694 RAIAIKCGIihPGEDflCLEGKEFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVT 773
Cdd:cd02077  517 KAICKQVGL--DINR--VLTGSEIE--------ALSDEELAKIVEETNIFAKLSPLQKARIIQAL-----KKNGHVVGFM 579
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  774 GDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVN---VVAVIVAft 850
Cdd:cd02077  580 GDGINDAPALRQADVGISVDSA-VDIAKEAADIILLEKDLMVLEEGVIEGRKTFGNILKYIKMTASSNfgnVFSVLVA-- 656
                        810       820       830
                 ....*....|....*....|....*....|..
gi 48255949  851 gACITQDSPLKAVQMLWVNLIMDtFASLALAT 882
Cdd:cd02077  657 -SAFLPFLPMLPIQLLLQNLLYD-FSQLAIPF 686
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
191-887 8.74e-68

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 241.80  E-value: 8.74e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  191 KFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGR 270
Cdd:cd02609   93 KVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLEVDESLLTGESDLIPKKAGDK--LLSGSFVVSGAAY 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  271 MLVTAVGVNSQtgiiftllgaggeeeekkdkkakqqdgAAAMEMQplksaeggdaddrkkASMHKKEKSVLQGKLTKLAV 350
Cdd:cd02609  171 ARVTAVGAESY---------------------------AAKLTLE---------------AKKHKLINSELLNSINKILK 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  351 qigkaglVMSAITVIILVLYFtVDTFVVNKKPWlpectpvyvqyfvKFFIIG-VTVLVVAVPEGLPLAVTISLAYSVKKM 429
Cdd:cd02609  209 -------FTSFIIIPLGLLLF-VEALFRRGGGW-------------RQAVVStVAALLGMIPEGLVLLTSVALAVGAIRL 267
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  430 MKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIpdpssiNTKTMELLINAIAINSAyTTKILp 509
Cdd:cd02609  268 AKKKVLVQELYSIETLARVDVLCLDKTGTITEGKMKVERVEPLDEANEAE------AAAALAAFVAASEDNNA-TMQAI- 339
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  510 pekegalprqvgnktecgLLGFVLDLKQdyePVRSQMPeeklykvytFNSVRKsMSTVIKLPDESFRMyskGASEIVLkk 589
Cdd:cd02609  340 ------------------RAAFFGNNRF---EVTSIIP---------FSSARK-WSAVEFRDGGTWVL---GAPEVLL-- 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  590 cckilngageprvfrpRDRDEMVKKVIEPMACDGLRTICVAYrdfpSSPEPDWDNendILNELTCICVVGIEDPVRPEVP 669
Cdd:cd02609  384 ----------------GDLPSEVLSRVNELAAQGYRVLLLAR----SAGALTHEQ---LPVGLEPLALILLTDPIRPEAK 440
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  670 EAIRKCQRAGITVRMVTGDNINTARAIAIKCGiihpgedflcLEGKEFNRRIRNEKGEIEQERIDKiwpKLRVLARSSPT 749
Cdd:cd02609  441 ETLAYFAEQGVAVKVISGDNPVTVSAIAKRAG----------LEGAESYIDASTLTTDEELAEAVE---NYTVFGRVTPE 507
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  750 DKHTLVKGIIDSTHTeqrqvVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDS 829
Cdd:cd02609  508 QKRQLVQALQALGHT-----VAMTGDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLLDSDFSALPDVVFEGRRVVNN 581
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 48255949  830 ISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTE 887
Cdd:cd02609  582 IERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNKR 639
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
193-851 4.92e-54

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 202.30  E-value: 4.92e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKSVDkDPmLLSGTHVMEGSGRML 272
Cdd:COG2217  216 RVLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS-VDESMLTGESLPVEKTPG-DE-VFAGTINLDGSLRVR 292
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  273 VTAVGVNSQ-TGIIftllgaggeeeekkdkkakqqdgaAAMEmqplkSAEGGDAddrkkasmhkkeksvlqgKLTKLAVQ 351
Cdd:COG2217  293 VTKVGSDTTlARII------------------------RLVE-----EAQSSKA------------------PIQRLADR 325
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  352 IgkaglvmSAI-TVIILVLyfTVDTFVVnkkpWLpectpVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMM 430
Cdd:COG2217  326 I-------ARYfVPAVLAI--AALTFLV----WL-----LFGGDFSTALYRAVAVLVIACPCALGLATPTAIMVGTGRAA 387
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  431 KDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHYKEIPDPSSINT--KTMELLIN---AIAINSAYTT 505
Cdd:COG2217  388 RRGILIKGGEALERLAKVDTVVFDKTGTLTEGKPEVT-----DVVPLDGLDEDELLAlaAALEQGSEhplARAIVAAAKE 462
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  506 KILPPEKegalPRQVGNKTECGLLGFVldlkqdyepvrsqmpEEKLYKVytfnsvrksmstviklpdesfrmyskgasei 585
Cdd:COG2217  463 RGLELPE----VEDFEAIPGKGVEATV---------------DGKRVLV------------------------------- 492
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  586 vlkkcckilngaGEPRVFRPR--DRDEMVKKVIEPMACDGLRTICVAyrdfpsspepdWDNEndilneltCICVVGIEDP 663
Cdd:COG2217  493 ------------GSPRLLEEEgiDLPEALEERAEELEAEGKTVVYVA-----------VDGR--------LLGLIALADT 541
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  664 VRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHpgedflclegkefnrrirnekgeieqeridkiwpklrVL 743
Cdd:COG2217  542 LRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELGIDE-------------------------------------VR 584
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  744 ARSSPTDKHTLVKGIIdsthtEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWG 823
Cdd:COG2217  585 AEVLPEDKAAAVRELQ-----AQGKKVAMVGDGINDAPALAAADVGIAMG-SGTDVAIEAADIVLMRDDLRGVPDAIRLS 658
                        650       660
                 ....*....|....*....|....*...
gi 48255949  824 RNVYDSISKFLQFQLTVNVVAVIVAFTG 851
Cdd:COG2217  659 RATMRIIRQNLFWAFGYNVIGIPLAAGG 686
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
172-851 1.28e-51

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 191.69  E-value: 1.28e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    172 DWSKEKQFRGLQSRIE-QEQKFTVVRA-GQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVR 249
Cdd:TIGR01525   36 ERAKSRASDALSALLAlAPSTARVLQGdGSEEEVPVEELQVGDIVIVRPGERIPVDGVVISGESE-VDESALTGESMPVE 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    250 KSVDKDpmLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkakqqdgaaamemqplksaeggdaddrK 329
Cdd:TIGR01525  115 KKEGDE--VFAGTINGDGSLTIRVTKLGEDSTLAQIVELV---------------------------------------E 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    330 KASMHKKEksvLQGKLTKLAVQIGKAGLVMSAITVIILVLYFtvdtfvvnkkPWLPECtpvyvqyfvkfFIIGVTVLVVA 409
Cdd:TIGR01525  154 EAQSSKAP---IQRLADRIASYYVPAVLAIALLTFVVWLALG----------ALWREA-----------LYRALTVLVVA 209
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    410 VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYV-GDVHYKEIPDPSSintk 488
Cdd:TIGR01525  210 CPCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDIEPlDDASEEELLALAA---- 285
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    489 TMELLIN---AIAINSAYTTKILPPekegaLPRQVGNKTECGLLGFVldlkQDYEPVRSQMPEEklykvytfnsvrksms 565
Cdd:TIGR01525  286 ALEQSSShplARAIVRYAKERGLEL-----PPEDVEEVPGKGVEATV----DGGREVRIGNPRF---------------- 340
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    566 tviklpdesfrMYSKGASEIVLKKCCKILNGAGEprvfrprdrdemvkkviepmacdGLRTICVAYRDfpsspepdwdne 645
Cdd:TIGR01525  341 -----------LGNRELAIEPISASPDLLNEGES-----------------------QGKTVVFVAVD------------ 374
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    646 ndilNELtcICVVGIEDPVRPEVPEAIRKCQRAG-ITVRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirne 724
Cdd:TIGR01525  375 ----GEL--LGVIALRDQLRPEAKEAIAALKRAGgIKLVMLTGDNRSAAEAVAAELGI---------------------- 426
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    725 kgeiEQEridkiwpklrVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEAS 804
Cdd:TIGR01525  427 ----DDE----------VHAELLPEDKLAIVKKL-----QEEGGPVAMVGDGINDAPALAAADVGIAMG-SGSDVAIEAA 486
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 48255949    805 DIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 851
Cdd:TIGR01525  487 DIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALGYNLVAIPLAAGG 533
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
858-1036 1.73e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 173.19  E-value: 1.73e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    858 SPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSG 937
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    938 RNAplhsppsehYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCSPLQ 1015
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 48255949   1016 LDQWMWCIFIGLGELVWGQVI 1036
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
172-851 9.00e-48

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 181.64  E-value: 9.00e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  172 DWSKEKQFRGLQSRIEQEQKF-TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRK 250
Cdd:cd02079  106 ERARSRARSALKALLSLAPETaTVLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS-VDESSLTGESLPVEK 184
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  251 SVDkDPmLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkakqqdgaaamemqplKSAEggdaddrkk 330
Cdd:cd02079  185 GAG-DT-VFAGTINLNGPLTIEVTKTGEDTTLAKIIRLV----------------------------EEAQ--------- 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  331 asmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIIlvlyftvdtfvvnkkpwlpecTPVYVQYFVKFFIIGVTVLVVAV 410
Cdd:cd02079  226 -----SSKPPLQRLADRFARYFTPAVLVLAALVFLF---------------------WPLVGGPPSLALYRALAVLVVAC 279
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  411 PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTV--VQAYVGDVHYKEIPDPSSINTK 488
Cdd:cd02079  280 PCALGLATPTAIVAGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVteIEPLEGFSEDELLALAAALEQH 359
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  489 TMELLinAIAINSAYTTKILPPEKEGalprQVGNKTECGLLGFVLDlkqdyepvrsqmpeeklykvytfnsvrksmstvi 568
Cdd:cd02079  360 SEHPL--ARAIVEAAEEKGLPPLEVE----DVEEIPGKGISGEVDG---------------------------------- 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  569 klpdesfRMYSKGASEIVlkkcckilngageprvfrprdRDEMVKKVIEPMACDGLRTICVAYRDFpsspepdwdnendi 648
Cdd:cd02079  400 -------REVLIGSLSFA---------------------EEEGLVEAADALSDAGKTSAVYVGRDG-------------- 437
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  649 lnelTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgei 728
Cdd:cd02079  438 ----KLVGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGI-------------------------- 487
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  729 eqeridkiwpkLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIIL 808
Cdd:cd02079  488 -----------DEVHAGLLPEDKLAIVKAL-----QAEGGPVAMVGDGINDAPALAQADVGIAMG-SGTDVAIETADIVL 550
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|...
gi 48255949  809 TDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 851
Cdd:cd02079  551 LSNDLSKLPDAIRLARRTRRIIKQNLAWALGYNAIALPLAALG 593
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
193-820 1.80e-47

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 181.14  E-value: 1.80e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKSVDkDPmLLSGThvMEGSGRML 272
Cdd:cd02094  142 RVIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVEGESS-VDESMLTGESLPVEKKPG-DK-VIGGT--INGNGSLL 216
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  273 VTAVGVNSQTgiifTLlgaggeeeekkdkkakqqdgAAAMEMqplksaeggdaddrkkasmhkkeksVLQGKLTKLAVQi 352
Cdd:cd02094  217 VRATRVGADT----TL--------------------AQIIRL-------------------------VEEAQGSKAPIQ- 246
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  353 gkaGLV--MSAITV-IILVLyfTVDTFVVnkkpWL---PECTPVYVqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSV 426
Cdd:cd02094  247 ---RLAdrVSGVFVpVVIAI--AILTFLV----WLllgPEPALTFA------LVAAVAVLVIACPCALGLATPTAIMVGT 311
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  427 KKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHykeiPDPSSINTKTMEL-----------LIN 495
Cdd:cd02094  312 GRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVT-----DVV----PLPGDDEDELLRLaasleqgsehpLAK 382
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  496 AIaINSAYTTKILPPEKEG--ALPrqvGnkteCGLLGFVldlkqdyepvrsqmpEEKLYKVytfnsvrksmstviklpde 573
Cdd:cd02094  383 AI-VAAAKEKGLELPEVEDfeAIP---G----KGVRGTV---------------DGRRVLV------------------- 420
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  574 sfrmyskGASEIVLKKCCKILNGAGEprvfrprdrdemvkkvIEPMACDGLRTICVAYrdfpsspepdwDNEndilnelt 653
Cdd:cd02094  421 -------GNRRLMEENGIDLSALEAE----------------ALALEEEGKTVVLVAV-----------DGE-------- 458
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  654 CICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgeieqeri 733
Cdd:cd02094  459 LAGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKELGI------------------------------- 507
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  734 DKiwpklrVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNF 813
Cdd:cd02094  508 DE------VIAEVLPEDKAEKVKKL-----QAQGKKVAMVGDGINDAPALAQADVGIAIG-SGTDVAIESADIVLMRGDL 575

                 ....*..
gi 48255949  814 SSIVKAV 820
Cdd:cd02094  576 RGVVTAI 582
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
151-851 6.49e-47

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 177.52  E-value: 6.49e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    151 WIEGAAILLSVIcvvLVTAFNDWSKEKQFRGLQSRIEQE-QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFI 229
Cdd:TIGR01512   18 YLEGALLLLLFS---IGETLEEYASGRARRALKALMELApDTARRLQGDSLEEVAVEELKVGDVVVVKPGERVPVDGEVL 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    230 QGNDLkIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkakqqdga 309
Cdd:TIGR01512   95 SGTSS-VDESALTGESVPVEKAPGDE--VFAGAINLDGVLTIEVTKLPADSTIAKIVNLV-------------------- 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    310 aamemqplKSAEggdaddrkkasmhkKEKSVLQGKLTKLAVQIGKAGLVMSAITVIIlvlyftvdtfvvnkkPWLPECTP 389
Cdd:TIGR01512  152 --------EEAQ--------------SRKAPTQRFIDRFARYYTPAVLAIALAAALV---------------PPLLGAGP 194
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    390 vyvqyFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqa 469
Cdd:TIGR01512  195 -----FLEWIYRALVLLVVASPCALVISAPAAYLSAISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVT-- 267
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    470 yvgDVHYKEIPDPSSINT--KTMELL---INAIAINSAYTTKILPPEkegalPRQVGNKTECGLLGFVldlkqdyepvrs 544
Cdd:TIGR01512  268 ---DVHPADGHSESEVLRlaAAAEQGsthPLARAIVDYARARELAPP-----VEDVEEVPGEGVRAVV------------ 327
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    545 qmpeeklykvytfnsvrksmstviklpdesfrmyskgaseivlkkcckilnGAGEPRVFRPRDRDEMVKKVIEPMaCDGL 624
Cdd:TIGR01512  328 ---------------------------------------------------DGGEVRIGNPRSLSEAVGASIAVP-ESAG 355
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    625 RTICVAYRDFpsspepdwdnendilnelTCICVVGIEDPVRPEVPEAIRKCQRAGI-TVRMVTGDNINTARAIAIKCGII 703
Cdd:TIGR01512  356 KTIVLVARDG------------------TLLGYIALSDELRPDAAEAIAELKALGIkRLVMLTGDRRAVAEAVARELGID 417
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    704 hpgedflclegkefnrrirnekgeieqeridkiwpklRVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGDGTNDGPAL 783
Cdd:TIGR01512  418 -------------------------------------EVHAELLPEDKLEIVKELREKAG-----PVAMVGDGINDAPAL 455
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 48255949    784 KKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 851
Cdd:TIGR01512  456 AAADVGIAMGASGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVIALGIILVLILLALFG 523
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
194-848 3.57e-45

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 172.46  E-value: 3.57e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDlKIDESSLTGESDQVRKSVDkDPmLLSGTHVMEGSGRMLV 273
Cdd:TIGR01511   96 LTKDGSIEEVPVALLQPGDIVKVLPGEKIPVDGTVIEGES-EVDESLVTGESLPVPKKVG-DP-VIAGTVNGTGSLVVRA 172
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    274 TAVGVNSQTGIIFTLLgaggeeeekkdkkakqqdgaaamemqplksaeggdaddrKKASMHKKEKSVLQGKLTKLavqig 353
Cdd:TIGR01511  173 TATGEDTTLAQIVRLV---------------------------------------RQAQQSKAPIQRLADKVAGY----- 208
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    354 kagLVMSAITVIILvlyftvdTFVVnkkpWLpectpvyvqyfvkF-FIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKD 432
Cdd:TIGR01511  209 ---FVPVVIAIALI-------TFVI----WL-------------FaLEFAVTVLIIACPCALGLATPTVIAVATGLAAKN 261
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    433 NNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHykeiPDPSSINTKTMELlINAIAINS---------AY 503
Cdd:TIGR01511  262 GVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVT-----DVH----VFGDRDRTELLAL-AAALEAGSehplakaivSY 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    504 TtkilppEKEGALPRQVGN-KTECGLlgfvlDLKQDYEPVRSQMPEEKLYKVYTfnsvrksmstvIKLPDESfrmysKGA 582
Cdd:TIGR01511  332 A------KEKGITLVTVSDfKAIPGI-----GVEGTVEGTKIQLGNEKLLGENA-----------IKIDGKA-----GQG 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    583 SEIVLkkcckilngageprvfrprdrdemvkkviepmacdglrticvayrdfpsspepdwdneNDILNELTCIcvVGIED 662
Cdd:TIGR01511  385 STVVL----------------------------------------------------------VAVNGELAGV--FALED 404
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    663 PVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgeieqeridkiwpklRV 742
Cdd:TIGR01511  405 QLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVAKELGI--------------------------------------DV 446
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    743 LARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMW 822
Cdd:TIGR01511  447 RAEVLPDDKAALIKKL-----QEKGPVVAMVGDGINDAPALAQADVGIAIG-AGTDVAIEAADVVLLRNDLNDVATAIDL 520
                          650       660
                   ....*....|....*....|....*.
gi 48255949    823 GRNVYDSISKFLQFQLTVNVVAVIVA 848
Cdd:TIGR01511  521 SRKTLRRIKQNLLWAFGYNVIAIPIA 546
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
52-848 9.14e-44

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 172.56  E-value: 9.14e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQD-----VTLiileiaaiisLGLSFYhp 126
Cdd:PRK10517   53 PEEELWKTFDTHP-EGL--NEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNpfnilLTI----------LGAISY-- 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   127 pgegnegcATaqggaEDEGeaeagwiegAAILLSVIcVVLVTAFNDWSKEKQFRG---LQSRIEQeqKFTVVRAGQV--- 200
Cdd:PRK10517  118 --------AT-----EDLF---------AAGVIALM-VAISTLLNFIQEARSTKAadaLKAMVSN--TATVLRVINDkge 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   201 ---VQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRK-----------SVDKDPMLLSGTHVME 266
Cdd:PRK10517  173 ngwLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKfattrqpehsnPLECDTLCFMGTNVVS 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   267 GSGRMLVTAVGVNSQTGIIftllgaggeeeekkdkkakqqdgaaamemqplksAEGGDADDRkkasmhkkEKSVLQGKLT 346
Cdd:PRK10517  253 GTAQAVVIATGANTWFGQL----------------------------------AGRVSEQDS--------EPNAFQQGIS 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   347 KLAVQIGKAGLVMSAitVIILVLYFTvdtfvvnKKPWlpectpvyvqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSV 426
Cdd:PRK10517  291 RVSWLLIRFMLVMAP--VVLLINGYT-------KGDW------------WEAALFALSVAVGLTPEMLPMIVTSTLARGA 349
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   427 KKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtVVQAYVgDVHYKeipdpssintKTMELLINAIaINSAYTTK 506
Cdd:PRK10517  350 VKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKI-VLENHT-DISGK----------TSERVLHSAW-LNSHYQTG 416
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   507 IlppekEGALPRQVgnkTECGLLGFVLDLKQDYEPVrSQMPeeklykvytFNSVRKSMSTVIKLPDESFRMYSKGASEIV 586
Cdd:PRK10517  417 L-----KNLLDTAV---LEGVDEESARSLASRWQKI-DEIP---------FDFERRRMSVVVAENTEHHQLICKGALEEI 478
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   587 LKKCCKI-LNGAGEPRVfrpRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEpDWD--NENDilneLTCICVVGIEDP 663
Cdd:PRK10517  479 LNVCSQVrHNGEIVPLD---DIMLRRIKRVTDTLNRQGLRVVAVATKYLPAREG-DYQraDESD----LILEGYIAFLDP 550
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   664 VRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGedflCLEGkefnrrirnekGEIEQ---ERIDKIWPKL 740
Cdd:PRK10517  551 PKETTAPALKALKASGVTVKILTGDSELVAAKVCHEVGLDAGE----VLIG-----------SDIETlsdDELANLAERT 615
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   741 RVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAV 820
Cdd:PRK10517  616 TLFARLTPMHKERIVTLLKREGH-----VVGFMGDGINDAPALRAADIGISVD-GAVDIAREAADIILLEKSLMVLEEGV 689
                         810       820       830
                  ....*....|....*....|....*....|...
gi 48255949   821 MWGRNVYDSISKFLqfQLTV-----NVVAVIVA 848
Cdd:PRK10517  690 IEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
158-922 3.04e-38

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 155.02  E-value: 3.04e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  158 LLSVICVVLVTA----FNDWSKEKQFRGLQSRieqeqKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGND 233
Cdd:cd02073   52 LLPLLFVLGVTAikegYEDIRRHKSDNEVNNR-----PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSE 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  234 LK----IDESSLTGESD-QVRKSVDKDPMLLSGTHVMEGSGRM--------LVTAVG---VNSQTGIIFT----LLGagg 293
Cdd:cd02073  127 PDglcyVETANLDGETNlKIRQALPETALLLSEEDLARFSGEIeceqpnndLYTFNGtleLNGGRELPLSpdnlLLR--- 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  294 eeeekkdkkakqqdGAAamemqpLKSAE---------GGDAddrkKASMHKKEKSVLQGKLTKLAVQIgkagLVMSAITV 364
Cdd:cd02073  204 --------------GCT------LRNTEwvygvvvytGHET----KLMLNSGGTPLKRSSIEKKMNRF----IIAIFCIL 255
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  365 IILVLYFTVDTFVVNKK-----PWL--PECTPVYVQYFVKF--FIIgvtVLVVAVPegLPLAVTISLAYSV--------K 427
Cdd:cd02073  256 IVMCLISAIGKGIWLSKhgrdlWYLlpKEERSPALEFFFDFltFII---LYNNLIP--ISLYVTIEVVKFLqsffinwdL 330
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  428 KMMKDNN----LVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYkeipdpssintktmeLLINAIAI-NSA 502
Cdd:cd02073  331 DMYDEETdtpaEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVDY---------------GFFLALALcHTV 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  503 YTTKILPPEK---------EGALPRQvgnkteCGLLGFVLdLKQDYEPV-RSQMPEEKLYK---VYTFNSVRKSMSTVIK 569
Cdd:cd02073  396 VPEKDDHPGQlvyqasspdEAALVEA------ARDLGFVF-LSRTPDTVtINALGEEEEYEilhILEFNSDRKRMSVIVR 468
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  570 LPDESFRMYSKGASEIVLKKCckilngAGEPRVFRprdrdEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNE---- 645
Cdd:cd02073  469 DPDGRILLYCKGADSVIFERL------SPSSLELV-----EKTQEHLEDFASEGLRTLCLAYREISEEEYEEWNEKydea 537
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  646 ---------------NDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPG-EDF 709
Cdd:cd02073  538 stalqnreelldevaEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGYSCRLLSEDmENL 617
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  710 -LCLEGKEFNrrirnekgEIEQERIDKIWPKLRVLA------RSSPTDKHTLVKGIIDSThteqRQVVAVTGDGTNDGPA 782
Cdd:cd02073  618 aLVIDGKTLT--------YALDPELERLFLELALKCkaviccRVSPLQKALVVKLVKKSK----KAVTLAIGDGANDVSM 685
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  783 LKKADVGfaMGIAGtdvaKE------ASDIILTddNFSSIVKAVM-WGRNVYDSISKFLQFQLTVNVVAVIV-----AFT 850
Cdd:cd02073  686 IQEAHVG--VGISG----QEgmqaarASDYAIA--QFRFLRRLLLvHGRWSYQRLAKLILYFFYKNIAFYLTqfwyqFFN 757
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  851 GAciTQDSPLKAVQMLWVNLImdtFASLalatePP----------TETLLLRKP----YGRNKPLIS-RTMMKNILgHAV 915
Cdd:cd02073  758 GF--SGQTLYDSWYLTLYNVL---FTSL-----PPlvigifdqdvSAETLLRYPelykPGQLNELFNwKVFLYWIL-DGI 826

                 ....*..
gi 48255949  916 YQLALIF 922
Cdd:cd02073  827 YQSLIIF 833
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
193-907 2.48e-36

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 149.02  E-value: 2.48e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   193 TVVR------AGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQV----------RKSVDKDP 256
Cdd:PRK15122  151 TVLRrghagaEPVRREIPMRELVPGDIVHLSAGDMIPADVRLIESRDLFISQAVLTGEALPVekydtlgavaGKSADALA 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   257 -----------MLLSGTHVMEGSGRMLVTAVGvnSQTgiIFtllgaggeeeekkdkkakqqdGAAAmemqplKSAEGgda 325
Cdd:PRK15122  231 ddegslldlpnICFMGTNVVSGTATAVVVATG--SRT--YF---------------------GSLA------KSIVG--- 276
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   326 dDRKKASMHKKEKSVlqgklTKLAVqigKAGLVMsaITVIILVLYFTvdtfvvnKKPWLPECTpvyvqyfvkfFiigvtV 405
Cdd:PRK15122  277 -TRAQTAFDRGVNSV-----SWLLI---RFMLVM--VPVVLLINGFT-------KGDWLEALL----------F-----A 323
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   406 LVVAV---PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYvgDVHYKEipdp 482
Cdd:PRK15122  324 LAVAVgltPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLTQDRIILEHHL--DVSGRK---- 397
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   483 ssiNTKTMELlinaIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFvldLKQDYEPvrsqmpeeklykvytFNSVRK 562
Cdd:PRK15122  398 ---DERVLQL----AWLNSFHQSGMKNLMDQAVVAFAEGNPEIVKPAGY---RKVDELP---------------FDFVRR 452
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   563 SMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGaGEPRVFRPRDRDEMVKKVIEPMAcDGLRTICVAYRDFPSSPEPDW 642
Cdd:PRK15122  453 RLSVVVEDAQGQHLLICKGAVEEMLAVATHVRDG-DTVRPLDEARRERLLALAEAYNA-DGFRVLLVATREIPGGESRAQ 530
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   643 ---DNENDILNE--LTCIcvvgieDPVRPEVPEAIRKCQRAGITVRMVTGDN-INTARaIAIKCGIiHPGEDflcLEGKE 716
Cdd:PRK15122  531 ystADERDLVIRgfLTFL------DPPKESAAPAIAALRENGVAVKVLTGDNpIVTAK-ICREVGL-EPGEP---LLGTE 599
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   717 FNRRIRNEKGEIEQERIdkiwpklrVLARSSPTDKHTLVKGIIDSTHTeqrqvVAVTGDGTNDGPALKKADVGFAMGiAG 796
Cdd:PRK15122  600 IEAMDDAALAREVEERT--------VFAKLTPLQKSRVLKALQANGHT-----VGFLGDGINDAPALRDADVGISVD-SG 665
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   797 TDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVAftGACITQdSPLKAVQMLWVNLI 871
Cdd:PRK15122  666 ADIAKESADIILLEKSLMVLEEGVIKGRETFGNIIKYL--NMTAssnfgNVFSVLVA--SAFIPF-LPMLAIHLLLQNLM 740
                         730       740       750
                  ....*....|....*....|....*....|....*....
gi 48255949   872 MDtFASLALatepPTETL---LLRKPYGRNKPLISRTMM 907
Cdd:PRK15122  741 YD-ISQLSL----PWDKMdkeFLRKPRKWDAKNIGRFML 774
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
194-848 4.50e-36

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 146.30  E-value: 4.50e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESdqvrKSVDKDP--MLLSGTHVMEGSGRM 271
Cdd:cd07552  135 LVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEGESS-VNESMVTGES----KPVEKKPgdEVIGGSVNGNGTLEV 209
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  272 LVTAVGVNSQTGIIFTLLgaggeeeekkdkkakqqdgaaamemqplksaeggdaddrKKAsmhKKEKSVLQGKLTKLAVQ 351
Cdd:cd07552  210 KVTKTGEDSYLSQVMELV---------------------------------------AQA---QASKSRAENLADKVAGW 247
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  352 IGKAGLVMSAITVIILVLYFTVDTFVvnkkpwlpectpvyvqyfvkffIIGVTVLVVAVPEGL----PLAVTISLAYSVK 427
Cdd:cd07552  248 LFYIALGVGIIAFIIWLILGDLAFAL----------------------ERAVTVLVIACPHALglaiPLVVARSTSIAAK 305
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  428 KMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYV-GDVHYKEIpdpssinTKTMELLIN------AIAIN 500
Cdd:cd07552  306 NGL----LIRNREALERARDIDVVLFDKTGTLTEGKFGVTDVITfDEYDEDEI-------LSLAAALEAgsehplAQAIV 374
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  501 SAYTTKILPPEKegalPRQVGNKTECGLLGFVldlkqdyepvrsqmpEEKLYKVYTFNSVRKSMstvIKLPDESFRMY-S 579
Cdd:cd07552  375 SAAKEKGIRPVE----VENFENIPGVGVEGTV---------------NGKRYQVVSPKYLKELG---LKYDEELVKRLaQ 432
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  580 KGASEIVLkkcckilngageprvfrprdrdemvkkviepmacdglrticvayrdfpsspepdwdnendiLNELTCICVVG 659
Cdd:cd07552  433 QGNTVSFL-------------------------------------------------------------IQDGEVIGAIA 451
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  660 IEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridkiwpk 739
Cdd:cd07552  452 LGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGID------------------------------------ 495
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  740 lRVLARSSPTDKHTLVKgiidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKA 819
Cdd:cd07552  496 -EYFAEVLPEDKAKKVK-----ELQAEGKKVAMVGDGVNDAPALAQADVGIAIG-AGTDVAIESADVVLVKSDPRDIVDF 568
                        650       660
                 ....*....|....*....|....*....
gi 48255949  820 VMWGRNVYDSISKFLQFQLTVNVVAVIVA 848
Cdd:cd07552  569 LELAKATYRKMKQNLWWGAGYNVIAIPLA 597
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
164-849 5.08e-36

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 148.68  E-value: 5.08e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    164 VVLVT----AFNDWSkekqfRGLQSRIEQEQKFTV-VRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLK--- 235
Cdd:TIGR01652   60 VLIVTaikeAIEDIR-----RRRRDKEVNNRLTEVlEGHGQFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDgvc 134
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    236 -IDESSLTGESD-QVRKSVDKDPMLLSGTHVMEGSGRmlVTAVGVNSQtgiIFTLLGaggeeeekkdkkAKQQDGAAAME 313
Cdd:TIGR01652  135 yVETANLDGETNlKLRQALEETQKMLDEDDIKNFSGE--IECEQPNAS---LYSFQG------------NMTINGDRQYP 197
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    314 MQP---------LKSAE---------GGDADDRKKASMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDt 375
Cdd:TIGR01652  198 LSPdnillrgctLRNTDwvigvvvytGHDTKLMRNATQAPSKRSRLEKELNFLIIILFCLLFVLCLISSVGAGIWNDAH- 276
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    376 fvvNKKPW---LPECTPVYVQYFVKFFIIGVTVLVVAVPegLPLAVTISLAYSVKKMMKDNNL------------VRHLD 440
Cdd:TIGR01652  277 ---GKDLWyirLDVSERNAAANGFFSFLTFLILFSSLIP--ISLYVSLELVKSVQAYFINSDLqmyhektdtpasVRTSN 351
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    441 ACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHY-----------------------KEIPDPSSINTKTMELL---- 493
Cdd:TIGR01652  352 LNEELGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYgdgfteikdgirerlgsyvenenSMLVESKGFTFVDPRLVdllk 431
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    494 ---INAIAINSAYTT-----KILP---PEKEGALPRQVGNKTECGL------LGFVLDLKQDY-----EPVRSQMPEEKL 551
Cdd:TIGR01652  432 tnkPNAKRINEFFLAlalchTVVPefnDDGPEEITYQAASPDEAALvkaardVGFVFFERTPKsisllIEMHGETKEYEI 511
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    552 YKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKkcckILNGAGeprvfrpRDRDEMVKKVIEPMACDGLRTICVAY 631
Cdd:TIGR01652  512 LNVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFK----RLSSGG-------NQVNEETKEHLENYASEGLRTLCIAY 580
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    632 RDFPSSPEPDW-----------DNENDILNE--------LTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINT 692
Cdd:TIGR01652  581 RELSEEEYEEWneeyneastalTDREEKLDVvaesiekdLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTGDKVET 660
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    693 ARAIAIKCGIIHPGEDFL---------CLEGKEFNRRIRNEKGEIEQERIDK---------------IWPKLR------- 741
Cdd:TIGR01652  661 AINIGYSCRLLSRNMEQIvitsdsldaTRSVEAAIKFGLEGTSEEFNNLGDSgnvalvidgkslgyaLDEELEkeflqla 740
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    742 -----VLA-RSSPTDKHTLVKGIIDSThteQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTD--VAKEASDIILTddNF 813
Cdd:TIGR01652  741 lkckaVICcRVSPSQKADVVRLVKKST---GKTTLAI-GDGANDVSMIQEADVG--VGISGKEgmQAVMASDFAIG--QF 812
                          810       820       830
                   ....*....|....*....|....*....|....*..
gi 48255949    814 SSIVKAVMW-GRNVYDSISKFLQFQLTVNVVAVIVAF 849
Cdd:TIGR01652  813 RFLTKLLLVhGRWSYKRISKMILYFFYKNLIFAIIQF 849
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
160-928 1.10e-33

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 140.96  E-value: 1.10e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    160 SVICVVLVTAFND---WSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKY--GDLLPADGLFIQGnDL 234
Cdd:TIGR01657  196 SLCIVFMSSTSISlsvYQIRKQMQRLRDMVHKPQSVIVIRNGKWVTIASDELVPGDIVSIPRpeEKTMPCDSVLLSG-SC 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    235 KIDESSLTGESDQVRK----------------SVDKDPMLLSGTHVM-----EGSGRML--VTAVGVN-SQTGIIFTLLg 290
Cdd:TIGR01657  275 IVNESMLTGESVPVLKfpipdngdddedlflyETSKKHVLFGGTKILqirpyPGDTGCLaiVVRTGFStSKGQLVRSIL- 353
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    291 aggeeeekkdkkakqqdgaaamemqplksaeggdaddrkkasmHKKEKSvlqgklTKLAVQIGKAGLVMSAITVIILVly 370
Cdd:TIGR01657  354 -------------------------------------------YPKPRV------FKFYKDSFKFILFLAVLALIGFI-- 382
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    371 FTVDTFVVNKKPwlpectpvyvqyfVKFFIIGVT-VLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNAT 449
Cdd:TIGR01657  383 YTIIELIKDGRP-------------LGKIILRSLdIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKID 449
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    450 AICSDKTGTLTTNRMTV--VQAYVGDVHY-KEIPDPSSINtktMELLINAIAINSAyTTKIlppekEGALprqVGNKTEC 526
Cdd:TIGR01657  450 VCCFDKTGTLTEDGLDLrgVQGLSGNQEFlKIVTEDSSLK---PSITHKALATCHS-LTKL-----EGKL---VGDPLDK 517
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    527 GLLGFV-LDLKQDYE---------PVRSQMPEEKLY--KVYTFNSVRKSMSTVIKLPDESFRM-YSKGASEIVLKKCCKi 593
Cdd:TIGR01657  518 KMFEATgWTLEEDDEsaeptsilaVVRTDDPPQELSiiRRFQFSSALQRMSVIVSTNDERSPDaFVKGAPETIQSLCSP- 596
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    594 lngagePRVfrPRDRDEMVKKVIEpmacDGLRTICVAYRDFPSSPepdWD-----NENDILNELTCICVVGIEDPVRPEV 668
Cdd:TIGR01657  597 ------ETV--PSDYQEVLKSYTR----EGYRVLALAYKELPKLT---LQkaqdlSRDAVESNLTFLGFIVFENPLKPDT 661
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    669 PEAIRKCQRAGITVRMVTGDNINTARAIAIKCGII------------------------HPGEDF--------------- 709
Cdd:TIGR01657  662 KEVIKELKRASIRTVMITGDNPLTAVHVARECGIVnpsntlilaeaeppesgkpnqikfEVIDSIpfastqveipyplgq 741
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    710 ------------LCLEGKEFNRRIRNEKgeieqERIDKIWPKLRVLARSSPTDKHTLVKgiidsTHTEQRQVVAVTGDGT 777
Cdd:TIGR01657  742 dsvedllasryhLAMSGKAFAVLQAHSP-----ELLLRLLSHTTVFARMAPDQKETLVE-----LLQKLDYTVGMCGDGA 811
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    778 NDGPALKKADVGFAM-----GIAGTDVAKEAS-----DIILTddnfssivkavmwGR-NVYDSISKFlQFQLTVNVVAVI 846
Cdd:TIGR01657  812 NDCGALKQADVGISLseaeaSVAAPFTSKLASiscvpNVIRE-------------GRcALVTSFQMF-KYMALYSLIQFY 877
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    847 VAFTGACItqDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRnkpLISRTMMKNILGhavyQLALIFTLLF 926
Cdd:TIGR01657  878 SVSILYLI--GSNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSKERPPSN---LFSVYILTSVLI----QFVLHILSQV 948

                   ..
gi 48255949    927 VG 928
Cdd:TIGR01657  949 YL 950
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
172-851 5.76e-33

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 136.25  E-value: 5.76e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  172 DWSKEKQFRGL-QSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRK 250
Cdd:cd07550   81 DYTARKSEKALlDLLSPQERTVWVERDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEK 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  251 SVDKdpMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkakqqdgaaamemqplksaeggdaddrKK 330
Cdd:cd07550  160 REGD--LVFASTVVEEGQLVIRAERVGRETRAARIAELI---------------------------------------EQ 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  331 ASMHKKEKsvlQGKLTKLAVQIGKAGLVMSAITviilvlyftvdtfvvnkkpwlpectpvyvqyfvkFFIIG-----VTV 405
Cdd:cd07550  199 SPSLKARI---QNYAERLADRLVPPTLGLAGLV----------------------------------YALTGdisraAAV 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  406 LVV----AVPEGLPLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAyvgdvhykeipd 481
Cdd:cd07550  242 LLVdfscGIRLSTPVAVLSALNHAARHGI----LVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAI------------ 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  482 pssintktmellinaIAINSAYttkilpPEKEgalprqvgnktecgLLGFVLDLkqdyepvrsqmpEEKLYKVYTFNSVR 561
Cdd:cd07550  306 ---------------ITFDGRL------SEED--------------LLYLAASA------------EEHFPHPVARAIVR 338
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  562 KSMSTVIKLPDESFRMY--SKG-ASEIVLKKcckILngAGEPRVFRPRDRD--EMVKKVIEPMACDGLRTICVAYrdfps 636
Cdd:cd07550  339 EAEERGIEHPEHEEVEYivGHGiASTVDGKR---IR--VGSRHFMEEEEIIliPEVDELIEDLHAEGKSLLYVAI----- 408
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  637 spepdwDNEndilneltCICVVGIEDPVRPEVPEAIRKCQRAG-ITVRMVTGDNINTARAIAikcgiihpgedflclegk 715
Cdd:cd07550  409 ------DGR--------LIGVIGLSDPLRPEAAEVIARLRALGgKRIIMLTGDHEQRARALA------------------ 456
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  716 efnrrirnekgeiEQERIDkiwpklRVLARSSPTDKHTLVKGIIDSTHTeqrqvVAVTGDGTNDGPALKKADVGFAMGiA 795
Cdd:cd07550  457 -------------EQLGID------RYHAEALPEDKAEIVEKLQAEGRT-----VAFVGDGINDSPALSYADVGISMR-G 511
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 48255949  796 GTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 851
Cdd:cd07550  512 GTDIARETADVVLLEDDLRGLAEAIELARETMALIKRNIALVVGPNTAVLAGGVFG 567
E1-E2_ATPase pfam00122
E1-E2 ATPase;
193-431 8.99e-33

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 125.38  E-value: 8.99e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKsvDKDPMLLSGTHVMEGSGRML 272
Cdd:pfam00122    8 TVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEK--KKGDMVYSGTVVVSGSAKAV 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    273 VTAVGVNSQTGIIFTLLgaggeeeekkdkkakqqdgaaamemqplksaeggdaddrkkaSMHKKEKSVLQGKLTKLAVQI 352
Cdd:pfam00122   85 VTATGEDTELGRIARLV------------------------------------------EEAKSKKTPLQRLLDRLGKYF 122
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 48255949    353 GKAGLVMSAITVIILVLYFTVDTFVvnkkpwlpectpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMK 431
Cdd:pfam00122  123 SPVVLLIALAVFLLWLFVGGPPLRA---------------------LLRALAVLVAACPCALPLATPLALAVGARRLAK 180
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
151-878 1.42e-32

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 135.24  E-value: 1.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  151 WIEGAAIllsVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKF-TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFI 229
Cdd:cd07545   59 WPEAAMV---VFLFAISEALEAYSMDRARRSIRSLMDIAPKTaLVRRDGQEREVPVAEVAVGDRMIVRPGERIAMDGIIV 135
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  230 QGNDLkIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGRMLVTAvgvnsqtgiiftllgaggeeeekkdkkaKQQDGA 309
Cdd:cd07545  136 RGESS-VNQAAITGESLPVEKGVGDE--VFAGTLNGEGALEVRVTK----------------------------PAEDST 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  310 AAMEMQPLKSAEGgdaddrkkasmhkkEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFvvnkkPWlpectp 389
Cdd:cd07545  185 IARIIHLVEEAQA--------------ERAPTQAFVDRFARYYTPVVMAIAALVAIVPPLFFGGAWF-----TW------ 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  390 VYVqyfvkffiiGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQA 469
Cdd:cd07545  240 IYR---------GLALLVVACPCALVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLKTVAFDKTGTLTKGKPVVTDV 310
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  470 YVgdvhykeipdpssintktmellinaiainsayttkilppekegalprqVGNKTECGLLGFVLDLKQdyepvRSQMPEE 549
Cdd:cd07545  311 VV------------------------------------------------LGGQTEKELLAIAAALEY-----RSEHPLA 337
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  550 KLYkvytfnsVRKSMSTVIKLPD-ESFR-MYSKGASEIVLKKCCKIlngaGEPRVFRPRDRDEMV--KKVIEPMACDGlR 625
Cdd:cd07545  338 SAI-------VKKAEQRGLTLSAvEEFTaLTGRGVRGVVNGTTYYI----GSPRLFEELNLSESPalEAKLDALQNQG-K 405
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  626 TICVayrdfpsspepdwdnendILNELTCICVVGIEDPVRPEVPEAIRKCQRAGI--TVrMVTGDNINTARAIAIKCGIi 703
Cdd:cd07545  406 TVMI------------------LGDGERILGVIAVADQVRPSSRNAIAALHQLGIkqTV-MLTGDNPQTAQAIAAQVGV- 465
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  704 hpgedflclegkefnrrirnekGEIEQERIdkiwpklrvlarssPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPAL 783
Cdd:cd07545  466 ----------------------SDIRAELL--------------PQDKLDAIEAL-----QAEGGRVAMVGDGVNDAPAL 504
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  784 KKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacitqdsplkaV 863
Cdd:cd07545  505 AAADVGIAMGAAGTDTALETADIALMGDDLRKLPFAVRLSRKTLAIIKQNIAFALGIKLIALLLVIPG-----------W 573
                        730
                 ....*....|....*
gi 48255949  864 QMLWVNLIMDTFASL 878
Cdd:cd07545  574 LTLWMAVFADMGASL 588
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
194-851 1.31e-31

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 132.37  E-value: 1.31e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDlKIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGRMLV 273
Cdd:cd07551  117 IQRDGEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSS-SIDEASITGESIPVEKTPGDE--VFAGTINGSGALTVRV 193
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  274 TAVgvNSQTgiIFtllgaggeeeekkdkkakqqdgaaAMEMQPLKSAEGgdaddrkkasmhkkEKSVLQGKLTKLavQIG 353
Cdd:cd07551  194 TKL--SSDT--VF------------------------AKIVQLVEEAQS--------------EKSPTQSFIERF--ERI 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  354 KAGLVMSAITVIILVLYFtvdtfvVNKKPWLPEctpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDN 433
Cdd:cd07551  230 YVKGVLLAVLLLLLLPPF------LLGWTWADS------------FYRAMVFLVVASPCALVASTPPATLSAIANAARQG 291
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  434 NLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHYKEIPDPSSINT--KTMELLIN---AIAINSAYTTKIL 508
Cdd:cd07551  292 VLFKGGVHLENLGSVKAIAFDKTGTLTEGKPRVT-----DVIPAEGVDEEELLQvaAAAESQSEhplAQAIVRYAEERGI 366
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  509 PPekegALPRQVGNKTECGLLGFVldlkqdyepvrsqmpEEKLYKVytfnsvrksmstviklpdesfrmyskgaseivlk 588
Cdd:cd07551  367 PR----LPAIEVEAVTGKGVTATV---------------DGQTYRI---------------------------------- 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  589 kcckilngaGEPRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDfpsspepdwdnendilnelTCICVVGIEDPVRPEV 668
Cdd:cd07551  394 ---------GKPGFFGEVGIPSEAAALAAELESEGKTVVYVARDD-------------------QVVGLIALMDTPRPEA 445
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  669 PEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgeieqeriDKIWPKLRvlarssP 748
Cdd:cd07551  446 KEAIAALRLGGIKTIMLTGDNERTAEAVAKELGI-------------------------------DEVVANLL------P 488
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  749 TDKhtlVKgIIDSTHTEQRQVvAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYD 828
Cdd:cd07551  489 EDK---VA-IIRELQQEYGTV-AMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMKDDLSKLPYAIRLSRKMRR 562
                        650       660
                 ....*....|....*....|...
gi 48255949  829 SISKFLQFQLTVNVVAVIVAFTG 851
Cdd:cd07551  563 IIKQNLIFALAVIALLIVANLFG 585
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
157-927 2.38e-31

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 132.76  E-value: 2.38e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  157 ILLSVICVVLVTafndWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKY-GDLLPADGLFIQGNDLk 235
Cdd:cd07542   58 VIISVISIFLSL----YETRKQSKRLREMVHFTCPVRVIRDGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSGSCI- 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  236 IDESSLTGESDQVRKSVDKDP-----------------MLLSGTHVME--GSGRMLVTAVGVnsQTGIIftllgaggeee 296
Cdd:cd07542  133 VNESMLTGESVPVTKTPLPDEsndslwsiysiedhskhTLFCGTKVIQtrAYEGKPVLAVVV--RTGFN----------- 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  297 ekkdkkakqqdgaaamemqplkSAEGgdadDRKKASMHKKEKSVlqgKLTK-----LAVQIGKAGLVMsAITVIILVLYF 371
Cdd:cd07542  200 ----------------------TTKG----QLVRSILYPKPVDF---KFYRdsmkfILFLAIIALIGF-IYTLIILILNG 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  372 TvdtfvvnkkpwlpectpvyvqYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKmmkdnnLVRHLDAC---ETMGNA 448
Cdd:cd07542  250 E---------------------SLGEIIIRALDIITIVVPPALPAALTVGIIYAQSR------LKKKGIFCispQRINIC 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  449 TAI---CSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILppekegalpRQVGNKte 525
Cdd:cd07542  303 GKInlvCFDKTGTLTEDGLDLWGVRPVSGNNFGDLEVFSLDLDLDSSLPNGPLLRAMATCHSL---------TLIDGE-- 371
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  526 cgLLGFVLDLKQ------DYEPVRSqmpeeklykvYTFNSVRKSMSTVIKLP-DESFRMYSKGASEIVLKKCckilngag 598
Cdd:cd07542  372 --LVGDPLDLKMfeftgwSLEILRQ----------FPFSSALQRMSVIVKTPgDDSMMAFTKGAPEMIASLC-------- 431
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  599 EPRVFrPRDRDEMVKKviepMACDGLRTICVAYRDFPSSPEPDWDNENDIL-NELTCICVVGIEDPVRPEVPEAIRKCQR 677
Cdd:cd07542  432 KPETV-PSNFQEVLNE----YTKQGFRVIALAYKALESKTWLLQKLSREEVeSDLEFLGLIVMENRLKPETAPVINELNR 506
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  678 AGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEfnrrirnEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKG 757
Cdd:cd07542  507 ANIRTVMVTGDNLLTAISVARECGMISPSKKVILIEAVK-------PEDDDSASLTWTLLLKGTVFARMSPDQKSELVEE 579
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  758 I--IDSThteqrqvVAVTGDGTNDGPALKKADVGFAMGIAGTDVakeASDIILTDDNFSSIVKAVMWGRNVYD---SISK 832
Cdd:cd07542  580 LqkLDYT-------VGMCGDGANDCGALKAADVGISLSEAEASV---AAPFTSKVPDISCVPTVIKEGRAALVtsfSCFK 649
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  833 FLqfqltvnVVAVIVAFTGACI--TQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRnkpLISRTMMKNI 910
Cdd:cd07542  650 YM-------ALYSLIQFISVLIlySINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKRPPAS---LVSPPVLVSL 719
                        810
                 ....*....|....*..
gi 48255949  911 LGHAVYQLALIFTLLFV 927
Cdd:cd07542  720 LGQIVLILLFQVIGFLI 736
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
190-851 2.42e-30

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 128.21  E-value: 2.42e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  190 QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKSvdkdpmllSGTHVMEGSg 269
Cdd:cd07544  110 RIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTAT-LDESSLTGESKPVSKR--------PGDRVMSGA- 179
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  270 rmlvtavgVNsqtgiiftllgaggeeeekkdkkakqqdGAAAMEMQPLKSAeggdADDRKK---ASMHKKEKSvlQGKLT 346
Cdd:cd07544  180 --------VN----------------------------GDSALTMVATKLA----ADSQYAgivRLVKEAQAN--PAPFV 217
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  347 KLAVQIGkaglvmsaitviilvLYFTVDTFVVNKKPWLPECTPVYVqyfvkffiigVTVLVVAVPEGLPLAVTISLAYSV 426
Cdd:cd07544  218 RLADRYA---------------VPFTLLALAIAGVAWAVSGDPVRF----------AAVLVVATPCPLILAAPVAIVSGM 272
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  427 KKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAyvgdvhykeIPDPssiNTKTMELL------------I 494
Cdd:cd07544  273 SRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQPKVVDV---------VPAP---GVDADEVLrlaasveqysshV 340
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  495 NAIAINSAYTTKILPPekegALPRQVGNKTECGLLGFVldlkqdyepvrsqmpEEKLYKVYTFNSVRKSMSTviklpDES 574
Cdd:cd07544  341 LARAIVAAARERELQL----SAVTELTEVPGAGVTGTV---------------DGHEVKVGKLKFVLARGAW-----APD 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  575 FRMYSKGASEIVLkkcckilngageprvfrprdrdemvkkviepmACDGlrTICVAYRdfpsspepdwdnendilneltc 654
Cdd:cd07544  397 IRNRPLGGTAVYV--------------------------------SVDG--KYAGAIT---------------------- 420
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  655 icvvgIEDPVRPEVPEAIRKCQRAGIT-VRMVTGDNINTARAIAIKCGIIHpgedflclegkefnrrirnekgeieqeri 733
Cdd:cd07544  421 -----LRDEVRPEAKETLAHLRKAGVErLVMLTGDRRSVAEYIASEVGIDE----------------------------- 466
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  734 dkiwpklrVLARSSPTDKHTLVKgiidsTHTEQRQVVAVtGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNF 813
Cdd:cd07544  467 --------VRAELLPEDKLAAVK-----EAPKAGPTIMV-GDGVNDAPALAAADVGIAMGARGSTAASEAADVVILVDDL 532
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|.
gi 48255949  814 SSIVKAVMWGRnvyDSISKFLQFQL---TVNVVAVIVAFTG 851
Cdd:cd07544  533 DRVVDAVAIAR---RTRRIALQSVLigmALSIIGMLIAAFG 570
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1081-1127 1.16e-26

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 103.25  E-value: 1.16e-26
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 48255949   1081 GQILWFRGLNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPE 1127
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLREGIQKPYLRNSIHSFMSHPE 47
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
160-800 2.80e-26

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 116.54  E-value: 2.80e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  160 SVICVVLVTAFND---WSKEKQFRGLQSRIEQEQKFTVVRAG-QVVQIPVAEIVVGDIAQVKY-GDLLPADGLFIQGNdL 234
Cdd:cd02082   53 AITVVFMTTINSLsciYIRGVMQKELKDACLNNTSVIVQRHGyQEITIASNMIVPGDIVLIKRrEVTLPCDCVLLEGS-C 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  235 KIDESSLTGESDQVRKSVDKDPMllsgthvmegsgrmlVTAVGVNSQTGIIFTLLGaggeeeekkdkkakqqdGAAAMEM 314
Cdd:cd02082  132 IVTEAMLTGESVPIGKCQIPTDS---------------HDDVLFKYESSKSHTLFQ-----------------GTQVMQI 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  315 QPLksaeggdADDRKKASMHKKEKSVLQGKLTKlAVQIGKA---GLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVY 391
Cdd:cd02082  180 IPP-------EDDILKAIVVRTGFGTSKGQLIR-AILYPKPfnkKFQQQAVKFTLLLATLALIGFLYTLIRLLDIELPPL 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  392 vqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtVVQAYV 471
Cdd:cd02082  252 -----FIAFEFLDILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKL-DLIGYQ 325
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  472 GDVHYKEIPDPSSINTKTMELLINAIAINSAyTTKIlppekEGALprqVGNKTECGLLGFV-LDLKQDYE----PVRSQM 546
Cdd:cd02082  326 LKGQNQTFDPIQCQDPNNISIEHKLFAICHS-LTKI-----NGKL---LGDPLDVKMAEAStWDLDYDHEakqhYSKSGT 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  547 PEEKLYKVYTFNSVRKSMSTV---IKLPDESFRMYS--KGASEIVLKKCCKIlngageprvfrPRDRdemvKKVIEPMAC 621
Cdd:cd02082  397 KRFYIIQVFQFHSALQRMSVVakeVDMITKDFKHYAfiKGAPEKIQSLFSHV-----------PSDE----KAQLSTLIN 461
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  622 DGLRTICVAYRDFPSSPEPDWDN--ENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIK 699
Cdd:cd02082  462 EGYRVLALGYKELPQSEIDAFLDlsREAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQE 541
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  700 CGIIHPGEDFLCLEGkefnrrIRNEKGEIEQERIDKIwPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTND 779
Cdd:cd02082  542 LEIINRKNPTIIIHL------LIPEIQKDNSTQWILI-IHTNVFARTAPEQKQTIIRLL-----KESDYIVCMCGDGAND 609
                        650       660
                 ....*....|....*....|.
gi 48255949  780 GPALKKADVGFAMGIAGTDVA 800
Cdd:cd02082  610 CGALKEADVGISLAEADASFA 630
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
193-882 1.48e-24

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 110.19  E-value: 1.48e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDlKIDESSLTGESDQVRKSvdkdpmllSGTHVMEGSgrml 272
Cdd:cd07546  102 LREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKA--------AGDKVFAGS---- 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  273 vtavgVNSqtgiiftllgaggeeeekkdkkakqqDGAAAMEmqpLKSAEGGDADDRKKASMHKKE--KSVLQGKLTKLAV 350
Cdd:cd07546  169 -----INV--------------------------DGVLRIR---VTSAPGDNAIDRILHLIEEAEerRAPIERFIDRFSR 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  351 QIGKAGLVMSAITVIILVLYFTVDTfvvnkKPWLPEctpvyvqyfvkffiiGVTVLVVAVPEGL----PLAVTISLAYSV 426
Cdd:cd07546  215 WYTPAIMAVALLVIVVPPLLFGADW-----QTWIYR---------------GLALLLIGCPCALvistPAAITSGLAAAA 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  427 KKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHYKEIPDPSsintktmELLINAIAINSAYT-- 504
Cdd:cd07546  275 RRGA----LIKGGAALEQLGRVTTVAFDKTGTLTRGKPVVT-----DVVPLTGISEA-------ELLALAAAVEMGSShp 338
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  505 --TKILP-PEKEGALPRQVGNKTecGLLGFVLDLKQDYEPVRsqmpeeklykvytfnsvrksmstviklpdesfrmyskg 581
Cdd:cd07546  339 laQAIVArAQAAGLTIPPAEEAR--ALVGRGIEGQVDGERVL-------------------------------------- 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  582 aseivlkkcckilngAGEPRVFRPRDRDEmVKKVIEPMACDGlRTICVAYRdfpsspepdwdnENDILNeltcicVVGIE 661
Cdd:cd07546  379 ---------------IGAPKFAADRGTLE-VQGRIAALEQAG-KTVVVVLA------------NGRVLG------LIALR 423
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  662 DPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgeDFlclegkefnrrirneKGEIeqeridkiwpklr 741
Cdd:cd07546  424 DELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELGL-----DF---------------RAGL------------- 470
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  742 vlarsSPTDKhtlVKGIidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVM 821
Cdd:cd07546  471 -----LPEDK---VKAV---RELAQHGPVAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAALTHNRLGGVAAMIE 538
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 48255949  822 WGRNVYDSISKFLQFQLTVNVVAVIVAFTGacITQdsplkavqmLWVNLIMDTFASlALAT 882
Cdd:cd07546  539 LSRATLANIRQNITIALGLKAVFLVTTLLG--ITG---------LWLAVLADTGAT-VLVT 587
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
189-847 4.46e-24

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 109.61  E-value: 4.46e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  189 EQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLK----IDESSLTGESD-QVRKSVDKDPMLLSGTH 263
Cdd:cd07536   82 KKQLYSKLTGRKVQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTSEPQgscyVETAQLDGETDlKLRVAVSCTQQLPALGD 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  264 VMEGSGrmLVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKAKQQDGAAAMEMQPLKSAEGgdaddrkkasmhkkeKSVLQG 343
Cdd:cd07536  162 LMKISA--YVECQKPQMDIHSFEGNFTLEDSDPPIHESLSIENTLLRASTLRNTGWVIG---------------VVVYTG 224
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  344 KLTKLAVQIGKAGLVMS-----------AITVIILVLYFTVDTFVVNKKPWLPEcTPVYVQY----FVKFFIIGVTVLVV 408
Cdd:cd07536  225 KETKLVMNTSNAKNKVGlldlelnrltkALFLALVVLSLVMVTLQGFWGPWYGE-KNWYIKKmdttSDNFGRNLLRFLLL 303
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  409 ---AVPEGLPLAVTISLAYSVKKMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVH 475
Cdd:cd07536  304 fsyIIPISLRVNLDMVKAVYAWFIMWDENMyyigndtgtvARTSTIPEELGQVVYLLTDKTGTLTQNEMIFKRCHIGGVS 383
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  476 YKeipdpssintktmellinaiainsayttkilppekegalprqvGNKTECGLLgfvldlkqdyepvrsqmpeeklyKVY 555
Cdd:cd07536  384 YG-------------------------------------------GQVLSFCIL-----------------------QLL 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  556 TFNSVRKSMSTVIKLPDES-FRMYSKGASEIVLkkcckilngagePRVfRPRDRDEMVKKVIEPMACDGLRTICVAYRDF 634
Cdd:cd07536  398 EFTSDRKRMSVIVRDESTGeITLYMKGADVAIS------------PIV-SKDSYMEQYNDWLEEECGEGLRTLCVAKKAL 464
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  635 PSSPEPDW------------DNE-------NDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARA 695
Cdd:cd07536  465 TENEYQEWesryteaslslhDRSlrvaevvESLERELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQETAIC 544
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  696 IAIKCGIIHP-------------GED-----FLCLEGKEFNRR------IRNEKGEI-----EQERID-KIWPKLRVLAR 745
Cdd:cd07536  545 IAKSCHLVSRtqdihllrqdtsrGERaaitqHAHLELNAFRRKhdvalvIDGDSLEValkyyRHEFVElACQCPAVICCR 624
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  746 SSPTDKHTLVKgiIDSTHTEQRQVvaVTGDGTNDGPALKKADVGfaMGIAGTD--VAKEASDIILTddNFSSIVKAVM-W 822
Cdd:cd07536  625 VSPTQKARIVT--LLKQHTGRRTL--AIGDGGNDVSMIQAADCG--VGISGKEgkQASLAADYSIT--QFRHLGRLLLvH 696
                        730       740
                 ....*....|....*....|....*
gi 48255949  823 GRNVYDSISKFLQFQLTVNVVAVIV 847
Cdd:cd07536  697 GRNSYNRSAALGQYVFYKGLIISTI 721
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
193-792 6.26e-23

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 105.93  E-value: 6.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  193 TVVRAGQVVQIPVAEIVVGDIAQVKYG---DLLPADGLFIQGNDLkIDESSLTGES-DQVRKSVDkdpmLLSGTHVMEGS 268
Cdd:cd07543   89 QVYRDGKWVPISSDELLPGDLVSIGRSaedNLVPCDLLLLRGSCI-VNEAMLTGESvPLMKEPIE----DRDPEDVLDDD 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  269 GRmlvtavgvnSQTGIIFTllgaggeeeekkdkkakqqdGAAAMEMQPLKSAEGGDADDRKKASMHKKEKSVLQGKLTK- 347
Cdd:cd07543  164 GD---------DKLHVLFG--------------------GTKVVQHTPPGKGGLKPPDGGCLAYVLRTGFETSQGKLLRt 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  348 --LAVQIGKAGLVMSAITVIILVLYFTVDTFVVnkkpWLPECTPVYVQYfvKFFIIGVTVLVVAVPEGLP----LAVTIS 421
Cdd:cd07543  215 ilFSTERVTANNLETFIFILFLLVFAIAAAAYV----WIEGTKDGRSRY--KLFLECTLILTSVVPPELPmelsLAVNTS 288
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  422 LAYSVKKMMKDNNLVR-----HLDACetmgnataiCSDKTGTLTTNRMtVVQAYVGDVHYKE-IPDPSSINTKTmellIN 495
Cdd:cd07543  289 LIALAKLYIFCTEPFRipfagKVDIC---------CFDKTGTLTSDDL-VVEGVAGLNDGKEvIPVSSIEPVET----IL 354
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  496 AIAinSAYTtkiLPPEKEGALprqVGNKTECGLLGFV---LDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTV--IKL 570
Cdd:cd07543  355 VLA--SCHS---LVKLDDGKL---VGDPLEKATLEAVdwtLTKDEKVFPRSKKTKGLKIIQRFHFSSALKRMSVVasYKD 426
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  571 P---DESFRMYSKGASEIV---LKKCckilngageprvfrPRDRDEMVKKviepMACDGLRTICVAYRDFPS---SPEPD 641
Cdd:cd07543  427 PgstDLKYIVAVKGAPETLksmLSDV--------------PADYDEVYKE----YTRQGSRVLALGYKELGHltkQQARD 488
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  642 WDNEnDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkeFNRRI 721
Cdd:cd07543  489 YKRE-DVESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLTACHVAKELGIV-------------DKPVL 554
                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 48255949  722 RNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVkgiidSTHTEQRQVVAVTGDGTNDGPALKKADVGFAM 792
Cdd:cd07543  555 ILILSEEGKSNEWKLIPHVKVFARVAPKQKEFII-----TTLKELGYVTLMCGDGTNDVGALKHAHVGVAL 620
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
198-824 1.20e-19

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 95.02  E-value: 1.20e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  198 GQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNdLKIDESSLTGESDQV-RKSVDKDPMLLSGTHVMEGSGRMLVTAv 276
Cdd:cd02078  104 GKIEKVPATDLKKGDIVLVEAGDIIPADGEVIEGV-ASVDESAITGESAPViRESGGDRSSVTGGTKVLSDRIKVRITA- 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  277 gvnsQTGIIFTllgaggeeeekkdkkakqqDGAAAMemqplksAEGGDaddRKKASmhkkeksvlqgklTKLAVQIGKAG 356
Cdd:cd02078  182 ----NPGETFL-------------------DRMIAL-------VEGAS---RQKTP-------------NEIALTILLVG 215
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  357 LvmSAITVIILVLYFTVDTFVVNKkpwlpectpvyvqyfvkffiIGVTVLV---VA-VPE---GLPLAVTISlaySVKKM 429
Cdd:cd02078  216 L--TLIFLIVVATLPPFAEYSGAP--------------------VSVTVLVallVClIPTtigGLLSAIGIA---GMDRL 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  430 MKDNNLVRHLDACETMGNATAICSDKTGTLTT-NRMTVvqayvgdvhyKEIPdpssINTKTMELLINAIAINSAYTTKil 508
Cdd:cd02078  271 LRFNVIAKSGRAVEAAGDVDTLLLDKTGTITLgNRQAT----------EFIP----VGGVDEKELADAAQLASLADET-- 334
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  509 ppeKEG----ALPRQVGNKTecgllgfvldlkqdYEPVRSQmpeeklYKVYTFnSVRKSMSTViKLPDEsfRMYSKGASE 584
Cdd:cd02078  335 ---PEGrsivILAKQLGGTE--------------RDLDLSG------AEFIPF-SAETRMSGV-DLPDG--TEIRKGAVD 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  585 IVLKKcckILNGAGEPrvfrPRDRDEMVKKVIE----PMAcdglrtICVAYRdfpsspepdwdnendILNeltcicVVGI 660
Cdd:cd02078  388 AIRKY---VRSLGGSI----PEELEAIVEEISKqggtPLV------VAEDDR---------------VLG------VIYL 433
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  661 EDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgEDFLclegkefnrrirnekgeieqeridkiwpkl 740
Cdd:cd02078  434 KDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV----DDFL------------------------------ 479
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  741 rvlARSSPTDKHTLVKgiidsthTEQRQ--VVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVK 818
Cdd:cd02078  480 ---AEAKPEDKLELIR-------KEQAKgkLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAGNMVDLDSDPTKLIE 548

                 ....*.
gi 48255949  819 AVMWGR 824
Cdd:cd02078  549 VVEIGK 554
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
497-593 1.28e-19

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 84.58  E-value: 1.28e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    497 IAINSAyttkILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKlykVYTFNSVRKSMSTVIKLPDES-F 575
Cdd:pfam13246    1 ALCNSA----AFDENEEKGKWEIVGDPTESALLVFAEKMGIDVEELRKDYPRVA---EIPFNSDRKRMSTVHKLPDDGkY 73
                           90
                   ....*....|....*...
gi 48255949    576 RMYSKGASEIVLKKCCKI 593
Cdd:pfam13246   74 RLFVKGAPEIILDRCTTI 91
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
164-836 1.85e-19

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 94.40  E-value: 1.85e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  164 VVLVT----AFNDWSkekqfRGLQSRIEQEQKFTVVraGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGND------ 233
Cdd:cd07541   58 VLAVTmakeAVDDIR-----RRRRDKEQNYEKLTVR--GETVEIPSSDIKVGDLIIVEKNQRIPADMVLLRTSEksgscf 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  234 LKIDEssLTGESD-QVRKSVDKDPMLLSGTHVMEgsgrmlVTAVGVNSQTGIIFTLLGAGGEEEEKKDKKAKQQDGA--- 309
Cdd:cd07541  131 IRTDQ--LDGETDwKLRIAVPCTQKLPEEGILNS------ISAVYAEAPQKDIHSFYGTFTINDDPTSESLSVENTLwan 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  310 ---AAMEMQPLKSAEGGDAddrkKASMHKKEKSVLQGKLTKlavQIGKAGLVMSAITVIILVLYFTVDTFvvnKKPWLpe 386
Cdd:cd07541  203 tvvASGTVIGVVVYTGKET----RSVMNTSQPKNKVGLLDL---EINFLTKILFCAVLALSIVMVALQGF---QGPWY-- 270
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  387 ctpVYVQYFVKFF--IIGVTvlvvavpeglpLAVTISLAYSV--KKMMKDNNL----VRHLDACETMGNATAICSDKTGT 458
Cdd:cd07541  271 ---IYLFRFLILFssIIPIS-----------LRVNLDMAKIVysWQIEHDKNIpgtvVRTSTIPEELGRIEYLLSDKTGT 336
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  459 LTTNRMTVVQAYVGDVHYkeipdpsSINTKTMELLinaiainsayttkilppekegalprqvgnktecgllgfvldlkqd 538
Cdd:cd07541  337 LTQNEMVFKKLHLGTVSY-------GGQNLNYEIL--------------------------------------------- 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  539 yepvrsqmpeeklyKVYTFNSVRKSMSTVIKLP-DESFRMYSKGAseivlkkcckilngageprvfrprdrDEMVKKVIE 617
Cdd:cd07541  365 --------------QIFPFTSESKRMGIIVREEkTGEITFYMKGA--------------------------DVVMSKIVQ 404
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  618 P----------MACDGLRTICVAYRDFPSSPEPDWDNEND-------------------ILNELTCICVVGIEDPVRPEV 668
Cdd:cd07541  405 YndwleeecgnMAREGLRTLVVAKKKLSEEEYQAFEKRYNaaklsihdrdlkvaevvesLERELELLCLTGVEDKLQEDV 484
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  669 PEAIRKCQRAGITVRMVTGDNINTARAIAIKCGI------IH-------PGEDFLCLEgkeFNRRIRNEK---------- 725
Cdd:cd07541  485 KPTLELLRNAGIKIWMLTGDKLETATCIAKSSKLvsrgqyIHvfrkvttREEAHLELN---NLRRKHDCAlvidgeslev 561
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  726 --GEIEQERIDKIWPKLRVLA-RSSPTDKHTLVKGIIDSThteQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTDvAKE 802
Cdd:cd07541  562 clKYYEHEFIELACQLPAVVCcRCSPTQKAQIVRLIQKHT---GKRTCAI-GDGGNDVSMIQAADVG--VGIEGKE-GKQ 634
                        730       740       750
                 ....*....|....*....|....*....|....*...
gi 48255949  803 AS---DIILTDdnFSSIVKAVMW-GRNVYDSISKFLQF 836
Cdd:cd07541  635 ASlaaDFSITQ--FSHIGRLLLWhGRNSYKRSAKLAQF 670
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
194-862 4.94e-17

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 86.26  E-value: 4.94e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRksVDKDPMLLSGTHVMEGSGRMLV 273
Cdd:cd02092  131 LQADGSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSGTSE-LDRSLLTGESAPVT--VAPGDLVQAGAMNLSGPLRLRA 207
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  274 TAVGVNsqtgiifTLLgaggeeeekkdkkakqQDGAAAMEMqplksAEGGDAddrkkasmhkkeksvlqgKLTKLAVQIg 353
Cdd:cd02092  208 TAAGDD-------TLL----------------AEIARLMEA-----AEQGRS------------------RYVRLADRA- 240
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  354 kAGLVMSAITVIILVlyftvdTFVVnkkpWLPECTPVYVQyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDN 433
Cdd:cd02092  241 -ARLYAPVVHLLALL------TFVG----WVAAGGDWRHA-----LLIAVAVLIITCPCALGLAVPAVQVVASGRLFRRG 304
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  434 NLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAyvgdvhykeipdpSSINTKTMELLiNAIAINSAYTTKILPPEKE 513
Cdd:cd02092  305 VLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLVGA-------------HAISADLLALA-AALAQASRHPLSRALAAAA 370
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  514 GALPRQVGNKTE---CGLLGFVLDLkqdyePVRSQMPEeklykvytFNSVRKSMSTviklpdesfrmyskgASEIVLKKc 590
Cdd:cd02092  371 GARPVELDDAREvpgRGVEGRIDGA-----RVRLGRPA--------WLGASAGVST---------------ASELALSK- 421
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  591 ckilnGAGEPRVFRprdrdemvkkviepmacdglrticvayrdfpsspepdwdnendilneltcicvvgIEDPVRPEVPE 670
Cdd:cd02092  422 -----GGEEAARFP-------------------------------------------------------FEDRPRPDARE 441
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  671 AIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHpgedflclegkefnrrirnekgeieqeridkiwpklrVLARSSPTD 750
Cdd:cd02092  442 AISALRALGLSVEILSGDREPAVRALARALGIED-------------------------------------WRAGLTPAE 484
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  751 KHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSI 830
Cdd:cd02092  485 KVARIEEL-----KAQGRRVLMVGDGLNDAPALAAAHVSMAPASA-VDASRSAADIVFLGDSLAPVPEAIEIARRARRLI 558
                        650       660       670
                 ....*....|....*....|....*....|..
gi 48255949  831 SKFLQFQLTVNVVAVIVAFTGacitQDSPLKA 862
Cdd:cd02092  559 RQNFALAIGYNVIAVPLAIAG----YVTPLIA 586
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
197-852 1.43e-16

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 84.93  E-value: 1.43e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    197 AGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNdLKIDESSLTGESDQVRKSVDKD-PMLLSGTHVMEGsgrMLVTA 275
Cdd:TIGR01497  113 DGAIDKVPADQLKKGDIVLVEAGDVIPCDGEVIEGV-ASVDESAITGESAPVIKESGGDfASVTGGTRILSD---WLVVE 188
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    276 VGVNSQTGIIftllgaggeeeekkdkkakqqDGAAAMemqplksAEGGDaddRKKASmhkkeksvlqgklTKLAVQIgka 355
Cdd:TIGR01497  189 CTANPGETFL---------------------DRMIAL-------VEGAQ---RRKTP-------------NEIALTI--- 221
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    356 glVMSAITVIILVLYFTVDTFVVnkkpWLPECTPVYVQyfvkffiigVTVLVVAVPE---GLPLAVTISlaySVKKMMKD 432
Cdd:TIGR01497  222 --LLIALTLVFLLVTATLWPFAA----YGGNAISVTVL---------VALLVCLIPTtigGLLSAIGIA---GMDRVLGF 283
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    433 NNLVRHLDACETMGNATAICSDKTGTLTT-NRMTVvqayvgdvhyKEIPdpssINTKTMELLINAIAINSAYTTKilpPE 511
Cdd:TIGR01497  284 NVIATSGRAVEACGDVDTLLLDKTGTITLgNRLAS----------EFIP----AQGVDEKTLADAAQLASLADDT---PE 346
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    512 KEGALprqvgnktecgLLGFVLDLKQDYEPVRSQMPEEklykvytfNSVRKSMSTvIKLPDEsfRMYSKGASEiVLKKCC 591
Cdd:TIGR01497  347 GKSIV-----------ILAKQLGIREDDVQSLHATFVE--------FTAQTRMSG-INLDNG--RMIRKGAVD-AIKRHV 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    592 KILNGageprVFrPRDRDEMVKKVIE----PMAcdglrtICVayrdfpsspepdwdnENDILNeltcicVVGIEDPVRPE 667
Cdd:TIGR01497  404 EANGG-----HI-PTDLDQAVDQVARqggtPLV------VCE---------------DNRIYG------VIYLKDIVKGG 450
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    668 VPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgEDFLclegkefnrrirnekgeieqeridkiwpklrvlARSS 747
Cdd:TIGR01497  451 IKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGV----DDFI---------------------------------AEAT 493
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    748 PTDKHTLVKgiidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVY 827
Cdd:TIGR01497  494 PEDKIALIR-----QEQAEGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAANMVDLDSDPTKLIEVVHIGKQLL 567
                          650       660
                   ....*....|....*....|....*....
gi 48255949    828 DSISKFLQFQLTVNVV---AVI-VAFTGA 852
Cdd:TIGR01497  568 ITRGALTTFSIANDVAkyfAIIpAIFAAA 596
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
660-824 1.74e-16

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 84.59  E-value: 1.74e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  660 IEDPVRPEVPEAIRKCQRAGIT-VRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgeieqeriDKIWP 738
Cdd:cd07548  426 ISDEIKEDAKEAIKGLKELGIKnLVMLTGDRKSVAEKVAKKLGI-------------------------------DEVYA 474
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  739 KLrvlarsSPTDKHTLVKGIIDsthtEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVK 818
Cdd:cd07548  475 EL------LPEDKVEKVEELKA----ESKGKVAFVGDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAE 544

                 ....*.
gi 48255949  819 AVMWGR 824
Cdd:cd07548  545 AIKIAR 550
copA PRK10671
copper-exporting P-type ATPase CopA;
194-820 7.57e-16

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 82.87  E-value: 7.57e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGnDLKIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSgrMLV 273
Cdd:PRK10671  327 VVTDEGEKSVPLADVQPGMLLRLTTGDRVPVDGEITQG-EAWLDEAMLTGEPIPQQKGEGDS--VHAGTVVQDGS--VLF 401
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   274 TAVGVNSQTG---IIftllgaggeeeekkdkkakqqdgaaamemqplksaeggdaddrkkasmhkkeKSVLQGKLTKlaV 350
Cdd:PRK10671  402 RASAVGSHTTlsrII----------------------------------------------------RMVRQAQSSK--P 427
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   351 QIGKAGLVMSAI---TVIILVLYFTVDTFVVNKKPWLpectpVYVqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVK 427
Cdd:PRK10671  428 EIGQLADKISAVfvpVVVVIALVSAAIWYFFGPAPQI-----VYT------LVIATTVLIIACPCALGLATPMSIISGVG 496
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   428 KMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgdvhykEIPDPSSINTKTMELLINAIAINSAY--TT 505
Cdd:PRK10671  497 RAAEFGVLVRDADALQRASTLDTLVFDKTGTLTEGKPQVV----------AVKTFNGVDEAQALRLAAALEQGSSHplAR 566
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   506 KILPPEKEGALPRQVGNKTECGLlgfvlDLKQDYEPVRSQMPEEKLYKVYTFNSvrKSMSTVIKlpdesfRMYSKGASEI 585
Cdd:PRK10671  567 AILDKAGDMTLPQVNGFRTLRGL-----GVSGEAEGHALLLGNQALLNEQQVDT--KALEAEIT------AQASQGATPV 633
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   586 VLkkcckilngageprvfrprdrdemvkkviepmACDGlrticvayrdfpsspepdwdnendilnelTCICVVGIEDPVR 665
Cdd:PRK10671  634 LL--------------------------------AVDG-----------------------------KAAALLAIRDPLR 652
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   666 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridkiwpklRVLAR 745
Cdd:PRK10671  653 SDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGID-------------------------------------EVIAG 695
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48255949   746 SSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAV 820
Cdd:PRK10671  696 VLPDGKAEAIKRL-----QSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAIETAAITLMRHSLMGVADAL 764
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
193-809 2.65e-14

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 77.73  E-value: 2.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGnDLKIDESSLTGESDQVRKsvdkdpmlLSGTHVMEGSgrml 272
Cdd:PRK11033  246 TRLRDGEREEVAIADLRPGDVIEVAAGGRLPADGKLLSP-FASFDESALTGESIPVER--------ATGEKVPAGA---- 312
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   273 vTAVgvnsqtgiiftllgaggeeeekkdkkakqqDGAAAMEmqpLKSAEGGDADDRkkaSMHKKE-----KSVLQGKLTK 347
Cdd:PRK11033  313 -TSV------------------------------DRLVTLE---VLSEPGASAIDR---ILHLIEeaeerRAPIERFIDR 355
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   348 LAVQIGKAGLVMSAITVIILVLYFTvdtfvvnkKPWLPEctpVYVqyfvkffiiGVTVLVVAVPEGL----PLAVTISLA 423
Cdd:PRK11033  356 FSRIYTPAIMLVALLVILVPPLLFA--------APWQEW---IYR---------GLTLLLIGCPCALvistPAAITSGLA 415
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   424 YSVKKmmkdNNLVRHLDACETMGNATAICSDKTGTLT--TNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIaINS 501
Cdd:PRK11033  416 AAARR----GALIKGGAALEQLGRVTTVAFDKTGTLTegKPQVTDIHPATGISESELLALAAAVEQGSTHPLAQAI-VRE 490
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   502 AYTTKILPPEKEgALPRQVGNktecGLLGFVldlkqdyepvrsqmpEEKLYKVYtfnsvrkSMSTVIKLPDEsfrmyskG 581
Cdd:PRK11033  491 AQVRGLAIPEAE-SQRALAGS----GIEGQV---------------NGERVLIC-------APGKLPPLADA-------F 536
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   582 ASEIVLkkcckiLNGAGEprvfrprdrdemvkkviepmacdglrTICVAYRDFpsspepdwdnendilnelTCICVVGIE 661
Cdd:PRK11033  537 AGQINE------LESAGK--------------------------TVVLVLRND------------------DVLGLIALQ 566
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   662 DPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgeDFlclegkefnrrirnekgeieqeridkiwpklr 741
Cdd:PRK11033  567 DTLRADARQAISELKALGIKGVMLTGDNPRAAAAIAGELGI-----DF-------------------------------- 609
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   742 vlaRSS--PTDKhtlVKGIidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILT 809
Cdd:PRK11033  610 ---RAGllPEDK---VKAV---TELNQHAPLAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAALT 669
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
205-862 6.82e-14

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 76.01  E-value: 6.82e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  205 VAEIVVGDIAQVKYGDLLPADGLFIQGNdLKIDESSLTGESDQVrkSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGI 284
Cdd:cd07553  143 ADQIKSGDVYLVASGQRVPVDGKLLSEQ-ASIDMSWLTGESLPR--IVERGDKVPAGTSLENQAFEIRVEHSLAESWSGS 219
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  285 IftllgaggeeeekkdkkakqqdgaaameMQPLKSAEggdaddrkkasmHKKEKSVLqgkLTKlavqigKAGLVMSAITV 364
Cdd:cd07553  220 I----------------------------LQKVEAQE------------ARKTPRDL---LAD------KIIHYFTVIAL 250
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  365 IILVLYFTVdtfvvnkkpWLPECTPVYVQYFVkffiigvTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACET 444
Cdd:cd07553  251 LIAVAGFGV---------WLAIDLSIALKVFT-------SVLIVACPCALALATPFTDEIALARLKKKGVLIKNASSLER 314
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  445 MGNATAICSDKTGTLTTNRMTVVQAyvgdvhykeipDPSSINTKtmellinaiAINSAYTTkilppekegalprqvgnkt 524
Cdd:cd07553  315 LSRVRTIVFDKTGTLTRGKSSFVMV-----------NPEGIDRL---------ALRAISAI------------------- 355
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  525 ecgllgfvldLKQDYEPVrSQMPEEKLYKVytfNSVRKSMSTVIKLPDESFRMYSKGaSEIVLKKCCkilngageprvfr 604
Cdd:cd07553  356 ----------EAHSRHPI-SRAIREHLMAK---GLIKAGASELVEIVGKGVSGNSSG-SLWKLGSAP------------- 407
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  605 prdrdemvkkviepMACDGLRTICVAYRDfpsspepdwdnendilneLTCICVVGIEDPVRPEVPEAIRKCQRAGITVRM 684
Cdd:cd07553  408 --------------DACGIQESGVVIARD------------------GRQLLDLSFNDLLRPDSNREIEELKKGGLSIAI 455
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  685 VTGDNINTARAIAikcgiihpgeDFLCLEGKEfnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKgiidsthT 764
Cdd:cd07553  456 LSGDNEEKVRLVG----------DSLGLDPRQ-------------------------LFGNLSPEEKLAWIE-------S 493
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  765 EQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVA 844
Cdd:cd07553  494 HSPENTLMVGDGANDALALASAFVGIAVA-GEVGVSLEAADIYYAGNGIGGIRDLLTLSKQTIKAIKGLFAFSLLYNLVA 572
                        650
                 ....*....|....*...
gi 48255949  845 VIVAFTGACitqdSPLKA 862
Cdd:cd07553  573 IGLALSGWI----SPLVA 586
PLN03190 PLN03190
aminophospholipid translocase; Provisional
399-696 3.81e-11

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 67.62  E-value: 3.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   399 FIIGVTVLVVAVPEGLPLA---VTISLAYSvkkMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTTNRMT 465
Cdd:PLN03190  394 FLMSVIVFQIMIPISLYISmelVRVGQAYF---MIRDDQMydeasnsrfqCRALNINEDLGQIKYVFSDKTGTLTENKME 470
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   466 VVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILP---------PEKEGA----------------LPRQV 520
Cdd:PLN03190  471 FQCASIWGVDYSDGRTPTQNDHAGYSVEVDGKILRPKMKVKVDPqllelsksgKDTEEAkhvhdfflalaacntiVPIVV 550
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   521 GNKTE---------------------CGLLGFVLDLKQDYEPVRSQMPEEKLYKV---YTFNSVRKSMSTVIKLPDESFR 576
Cdd:PLN03190  551 DDTSDptvklmdyqgespdeqalvyaAAAYGFMLIERTSGHIVIDIHGERQRFNVlglHEFDSDRKRMSVILGCPDKTVK 630
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   577 MYSKGASEIVLKKCCKILNgagePRVFRPrdrdemVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNE----------- 645
Cdd:PLN03190  631 VFVKGADTSMFSVIDRSLN----MNVIRA------TEAHLHTYSSLGLRTLVVGMRELNDSEFEQWHFSfeaastaligr 700
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 48255949   646 --------NDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAI 696
Cdd:PLN03190  701 aallrkvaSNVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISI 759
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
657-842 1.02e-09

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 62.80  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   657 VVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridki 736
Cdd:PRK14010  435 VIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVD--------------------------------- 481
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949   737 wpklRVLARSSPTDKHTLVKgiidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSI 816
Cdd:PRK14010  482 ----RFVAECKPEDKINVIR-----EEQAKGHIVAMTGDGTNDAPALAEANVGLAMN-SGTMSAKEAANLIDLDSNPTKL 551
                         170       180
                  ....*....|....*....|....*.
gi 48255949   817 VKAVMWGRNVYDSISKFLQFQLTVNV 842
Cdd:PRK14010  552 MEVVLIGKQLLMTRGSLTTFSIANDI 577
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
648-787 5.42e-08

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 54.13  E-value: 5.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    648 ILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFnrrirnekge 727
Cdd:pfam00702   83 VLVELLGVIALADELKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDVGV---------- 152
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    728 ieqeridkiwpklrvlARSSPTDKHTLVKGIIDSTHteqrQVVAVtGDGTNDGPALKKAD 787
Cdd:pfam00702  153 ----------------GKPKPEIYLAALERLGVKPE----EVLMV-GDGVNDIPAAKAAG 191
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
50-112 6.19e-07

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 47.94  E-value: 6.19e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 48255949     50 YGDTEAICRRLKTSPVEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILE 112
Cdd:pfam00690    3 ALSVEEVLKKLGTDLEKGL--TEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILL 63
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
666-812 4.41e-06

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 48.59  E-value: 4.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  666 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPgedFLCLEGKEfnrrIRNEKGE------IEQERIDKIWPK 739
Cdd:COG0561   22 PRTKEALRRLREKGIKVVIATGRPLRSALPLLEELGLDDP---LITSNGAL----IYDPDGEvlyerpLDPEDVREILEL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949  740 LR-------VLARSSPT---------DKHTLVKGIIDSTHTEQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEA 803
Cdd:COG0561   95 LRehglhlqVVVRSGPGfleilpkgvSKGSALKKLAERLGIPPEEVIAF-GDSGNDLEMLEAAGLGVAMGNA-PPEVKAA 172

                 ....*....
gi 48255949  804 SDIIlTDDN 812
Cdd:COG0561  173 ADYV-TGSN 180
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
721-819 8.55e-04

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 42.61  E-value: 8.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255949    721 IRNEKGEIEQ--ERIDKIWPKLRVLARSSP---------TDKHTLVKGIIDSTHTEQRQVVAVtGDGTNDGPALKKADVG 789
Cdd:pfam08282  147 ILLDEEDLDEleKELKELFGSLITITSSGPgyleimpkgVSKGTALKALAKHLNISLEEVIAF-GDGENDIEMLEAAGLG 225
                           90       100       110
                   ....*....|....*....|....*....|
gi 48255949    790 FAMGIAgTDVAKEASDIILTDDNFSSIVKA 819
Cdd:pfam08282  226 VAMGNA-SPEVKAAADYVTDSNNEDGVAKA 254
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
770-812 9.81e-04

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 42.26  E-value: 9.81e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 48255949    770 VAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 812
Cdd:TIGR00099  207 VIAFGDGMNDIEMLEAAGYGVAMGNA-DEELKALADYV-TDSN 247
HAD_HPP cd07517
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate ...
751-822 9.53e-03

phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily; Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319819 [Multi-domain]  Cd Length: 213  Bit Score: 38.74  E-value: 9.53e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 48255949  751 KHTLVKGIIDSTHTEQRQVVAVtGDGTNDGPALKKADVGFAMGIAGTDVaKEASDIIlTDDNFSS-IVKAVMW 822
Cdd:cd07517  142 KAKGIQKVIEHLGIKKEETMAF-GDGLNDIEMLEAVGIGIAMGNAHEEL-KEIADYV-TKDVDEDgILKALKH 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH