NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|153082755|ref|NP_001538|]
View 

interferon-induced protein with tetratricopeptide repeats 2 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 18770923)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  30708253|22404999|21153002
SCOP:  4001344

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 152-417 8.04e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 77.46  E-value: 8.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 152 NQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWppsQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEge 231
Cdd:COG2956   22 GQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEY---DRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAE-- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 232 geKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYrakvfqvmnlRENGMYGKrk 311
Cdd:COG2956   97 --ELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELY----------LEQGDYDE-- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 312 llelighAVAHLKKADEANDNLFRVCSILASLHALADQYEDAEYYFQKEFSK--ELTPVAKQLLHLrygnfqLYQMKCED 389
Cdd:COG2956  163 -------AIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQdpDYLPALPRLAEL------YEKLGDPE 229

                        250       260
                 ....*....|....*....|....*...
gi 153082755 390 KAIHHFIEGVKINQKSREKEKMKDKLQK 417
Cdd:COG2956  230 EALELLRKALELDPSDDLLLALADLLER 257
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 57-208 5.05e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.26  E-value: 5.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755  57 LAYLKHLKGQNEAALECLRKAEELiqqeHADQAEIrslvtWGNYAWVYYHMGRLSDVQIYVDKVKHVcekfsSPyriESP 136
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKALEL----DPDNPEA-----FALLGEILLQLGDLDEAIVLLHEALEL-----DP---DEP 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 153082755 137 ELDCEEGWTRLKCGgnQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWPpsqNAIDPLRQAIRLNPDN 208
Cdd:COG4783   73 EARLNLGLALLKAG--DYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPD---EAIAALEKALELDPDD 139
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 152-417 8.04e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 77.46  E-value: 8.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 152 NQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWppsQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEge 231
Cdd:COG2956   22 GQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEY---DRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAE-- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 232 geKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYrakvfqvmnlRENGMYGKrk 311
Cdd:COG2956   97 --ELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELY----------LEQGDYDE-- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 312 llelighAVAHLKKADEANDNLFRVCSILASLHALADQYEDAEYYFQKEFSK--ELTPVAKQLLHLrygnfqLYQMKCED 389
Cdd:COG2956  163 -------AIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQdpDYLPALPRLAEL------YEKLGDPE 229

                        250       260
                 ....*....|....*....|....*...
gi 153082755 390 KAIHHFIEGVKINQKSREKEKMKDKLQK 417
Cdd:COG2956  230 EALELLRKALELDPSDDLLLALADLLER 257
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 152-403 5.82e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.93  E-value: 5.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755  152 NQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWppsQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEGe 231
Cdd:TIGR02917 275 KNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNL---EQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIA- 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755  232 gekLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGccyrakvfqVMNLrengMYGKRK 311
Cdd:TIGR02917 351 ---TLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLG---------ISKL----SQGDPS 414

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755  312 lleligHAVAHLKKADEANDNLFRVCSILAsLHALADQYEDAEYYFQKEFSKElTPVAKQLLHLRYGnfqLYQMKCE-DK 390
Cdd:TIGR02917 415 ------EAIADLETAAQLDPELGRADLLLI-LSYLRSGQFDKALAAAKKLEKK-QPDNASLHNLLGA---IYLGKGDlAK 483

                         250
                  ....*....|...
gi 153082755  391 AIHHFIEGVKINQ 403
Cdd:TIGR02917 484 AREAFEKALSIEP 496
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 57-208 5.05e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.26  E-value: 5.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755  57 LAYLKHLKGQNEAALECLRKAEELiqqeHADQAEIrslvtWGNYAWVYYHMGRLSDVQIYVDKVKHVcekfsSPyriESP 136
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKALEL----DPDNPEA-----FALLGEILLQLGDLDEAIVLLHEALEL-----DP---DEP 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 153082755 137 ELDCEEGWTRLKCGgnQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWPpsqNAIDPLRQAIRLNPDN 208
Cdd:COG4783   73 EARLNLGLALLKAG--DYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPD---EAIAALEKALELDPDD 139
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 152-417 8.04e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 77.46  E-value: 8.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 152 NQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWppsQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEge 231
Cdd:COG2956   22 GQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEY---DRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAE-- 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 232 geKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYrakvfqvmnlRENGMYGKrk 311
Cdd:COG2956   97 --ELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELY----------LEQGDYDE-- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 312 llelighAVAHLKKADEANDNLFRVCSILASLHALADQYEDAEYYFQKEFSK--ELTPVAKQLLHLrygnfqLYQMKCED 389
Cdd:COG2956  163 -------AIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQdpDYLPALPRLAEL------YEKLGDPE 229

                        250       260
                 ....*....|....*....|....*...
gi 153082755 390 KAIHHFIEGVKINQKSREKEKMKDKLQK 417
Cdd:COG2956  230 EALELLRKALELDPSDDLLLALADLLER 257
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
152-392 5.09e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 5.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 152 NQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWppsQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMReegeEEGE 231
Cdd:COG0457   22 GRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRY---EEALADYEQALELDPDDAEALNNLGLALQALG----RYEE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 232 GEKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYRAkvfqvmnlrengmygkrk 311
Cdd:COG0457   95 ALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEK------------------ 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 312 lLELIGHAVAHLKKADEANDNLFRVCSILASLHALADQYEDAEYYFQKEFSKELTPVAKQLLHLRYGNFQLYQMKCEDKA 391
Cdd:COG0457  157 -LGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRL 235


                 .
gi 153082755 392 I 392
Cdd:COG0457  236 A 236
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 156-281 9.14e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 59.25  E-value: 9.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 156 RAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWppsQNAIDPLRQAIRLNPDNQYLKVLLALklhkMREEGEEEGEGEKL 235
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRY---DEALAAYEKALRLDPDNADALLDLAE----ALLAAGDTEEAEEL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 153082755 236 VEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNA 281
Cdd:COG4235   74 LERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADA 119
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 192-377 1.17e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 63.86  E-value: 1.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 192 QNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEgegeKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLK 271
Cdd:COG3914   95 EEALALYRRALALNPDNAEALFNLGNLLLALGRLEEAL----AALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALR 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 272 KALEYIPNNAYLHCQIGCCyrakvfqvmnLRENGMYGKrkllelighAVAHLKKADEANDNLFRVCSILASLHALADQYE 351
Cdd:COG3914  171 RALELDPDNAEALNNLGNA----------LQDLGRLEE---------AIAAYRRALELDPDNADAHSNLLFALRQACDWE 231

                        170       180
                 ....*....|....*....|....*.
gi 153082755 352 DAEYYFQKEFSKELTPVAKQLLHLRY 377
Cdd:COG3914  232 VYDRFEELLAALARGPSELSPFALLY 257
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 152-280 5.97e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.51  E-value: 5.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 152 NQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWppsQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEge 231
Cdd:COG4783   18 GDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDL---DEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEAL-- 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 153082755 232 geKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNN 280
Cdd:COG4783   93 --ALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
55-276 4.28e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.94  E-value: 4.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755  55 NLLAYLKHLKGQNEAALECLRKAEElIQQEHADqaeirslvTWGNYAWVYYHMGRLSDVQIYVDKVKHVCEKFSSPYrie 134
Cdd:COG0457   12 NNLGLAYRRLGRYEEAIEDYEKALE-LDPDDAE--------ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAL--- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 135 speldCEEGWTRLKCGgnQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWppsQNAIDPLRQAIRLNPDNQYLKVL 214
Cdd:COG0457   80 -----NNLGLALQALG--RYEEALEDYDKALELDPDDAEALYNLGLALLELGRY---DEAIEAYERALELDPDDADALYN 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 153082755 215 LALKLHKMREEGEEEGEGEKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEY 276
Cdd:COG0457  150 LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKL 211
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 178-293 5.19e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.73  E-value: 5.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 178 LAIASYRLDNWppsQNAIDPLRQAIRLNPDNQYLKVLLAlklhKMREEGEEEGEGEKLVEEALEKAPGVTDVLRSAAKFY 257
Cdd:COG4783   10 LAQALLLAGDY---DEAEALLEKALELDPDNPEAFALLG----EILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLAL 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 153082755 258 RRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYRA 293
Cdd:COG4783   83 LKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRA 118
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 253-458 1.20e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 253 AAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYRAKvfqvmnlrenGMYGKrkllelighAVAHLKKADEANDN 332
Cdd:COG2956   14 KGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRR----------GEYDR---------AIRIHQKLLERDPD 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 333 LFRVCSILASLHALADQYEDAEYYFQK--EFSKELTPVAKQLLHLrygnfqLYQMKCEDKAIHHFIEGVKINQKSRE--- 407
Cdd:COG2956   75 RAEALLELAQDYLKAGLLDRAEELLEKllELDPDDAEALRLLAEI------YEQEGDWEKAIEVLERLLKLGPENAHayc 148

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 153082755 408 -------KEKMKDKLQKIAKMRLSKNGADSEALHVLAFLQELNEKMQQADEDSERGLE 458
Cdd:COG2956  149 elaelylEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 152-275 5.06e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 5.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 152 NQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWppsQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMreegEEEGE 231
Cdd:COG2956  158 GDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDY---EEAIAALERALEQDPDYLPALPRLAELYEKL----GDPEE 230

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 153082755 232 GEKLVEEALEKAPGVTDVLRsAAKFYRRKDEPDKAIELLKKALE 275
Cdd:COG2956  231 ALELLRKALELDPSDDLLLA-LADLLERKEGLEAALALLERQLR 273
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 234-359 5.28e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.03  E-value: 5.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 234 KLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGccyrakvfqvMNLRENGMYGKrkll 313
Cdd:COG4783   25 ALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLG----------LALLKAGDYDE---- 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 153082755 314 elighAVAHLKKADEANDNLFRVCSILASLHALADQYEDAEYYFQK 359
Cdd:COG4783   91 -----ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEK 131
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 172-402 7.20e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.53  E-value: 7.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 172 PEFTSGLAIASYRLDNWPPSQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEGEGEKLVEEA--LEKAPGVTDV 249
Cdd:COG3914    1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAaaAAALLLLAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 250 LRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYRAkvfqvmnlrengmygkrklLELIGHAVAHLKKADEA 329
Cdd:COG3914   81 LELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLA-------------------LGRLEEALAALRRALAL 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 153082755 330 NDNLFRVCSILASLHALADQYEDAEYYFQKEFskELTPvAKQLLHLRYGNFqLYQMKCEDKAIHHFIEGVKIN 402
Cdd:COG3914  142 NPDFAEAYLNLGEALRRLGRLEEAIAALRRAL--ELDP-DNAEALNNLGNA-LQDLGRLEEAIAAYRRALELD 210
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 152-287 1.02e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.15  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 152 NQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWppsQNAIDPLRQAIRLNPDNqylkvllalklhkmreegeeege 231
Cdd:COG3914  126 GRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRL---EEAIAALRRALELDPDN----------------------- 179

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 153082755 232 geklveealekapgvTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQI 287
Cdd:COG3914  180 ---------------AEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 152-403 5.82e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.93  E-value: 5.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755  152 NQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWppsQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEGe 231
Cdd:TIGR02917 275 KNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNL---EQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIA- 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755  232 gekLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGccyrakvfqVMNLrengMYGKRK 311
Cdd:TIGR02917 351 ---TLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLG---------ISKL----SQGDPS 414

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755  312 lleligHAVAHLKKADEANDNLFRVCSILAsLHALADQYEDAEYYFQKEFSKElTPVAKQLLHLRYGnfqLYQMKCE-DK 390
Cdd:TIGR02917 415 ------EAIADLETAAQLDPELGRADLLLI-LSYLRSGQFDKALAAAKKLEKK-QPDNASLHNLLGA---IYLGKGDlAK 483

                         250
                  ....*....|...
gi 153082755  391 AIHHFIEGVKINQ 403
Cdd:TIGR02917 484 AREAFEKALSIEP 496
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 152-222 2.76e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.18  E-value: 2.76e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 153082755 152 NQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWppsQNAIDPLRQAIRLNPDNQYLKVLLALKLHKM 222
Cdd:COG5010   68 GDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDK---DEAKEYYEKALALSPDNPNAYSNLAALLLSL 135
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 57-208 5.05e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.26  E-value: 5.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755  57 LAYLKHLKGQNEAALECLRKAEELiqqeHADQAEIrslvtWGNYAWVYYHMGRLSDVQIYVDKVKHVcekfsSPyriESP 136
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKALEL----DPDNPEA-----FALLGEILLQLGDLDEAIVLLHEALEL-----DP---DEP 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 153082755 137 ELDCEEGWTRLKCGgnQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWPpsqNAIDPLRQAIRLNPDN 208
Cdd:COG4783   73 EARLNLGLALLKAG--DYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPD---EAIAALEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 146-378 5.82e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.84  E-value: 5.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755  146 RLKCGGNQNERAKVCFEKALEKKPKNPEFTSGLAiASYRLDNWPpsQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREE 225
Cdd:TIGR02917 541 GLYLRTGNEEEAVAWLEKAAELNPQEIEPALALA-QYYLGKGQL--KKALAILNEAADAAPDSPEAWLMLGRAQLAAGDL 617

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755  226 GEEEGEGEKLVEEALEKAPgvtdVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNaylhcqigccYRAKVFQVMNLRENG 305
Cdd:TIGR02917 618 NKAVSSFKKLLALQPDSAL----ALLLLADAYAVMKNYAKAITSLKRALELKPDN----------TEAQIGLAQLLLAAK 683

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 153082755  306 MygkrkllelIGHAVAHLKKADEANDNLFRVCSILASLHALADQYEDAEYYFQKEFSKELTPVAKQLLHLRYG 378
Cdd:TIGR02917 684 R---------TESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRALL 747
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 237-359 6.64e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.69  E-value: 6.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 237 EEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGccyrakvfqvMNLRENGMYGKrklleli 316
Cdd:COG4235    7 RQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLA----------EALLAAGDTEE------- 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 153082755 317 ghAVAHLKKADEANDNLFRVCSILASLHALADQYEDAEYYFQK 359
Cdd:COG4235   70 --AEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQK 110
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
55-273 1.67e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 1.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755  55 NLLAYLKHLKGQNEAALECLRKAEELiqqehadqaEIRSLVTWGNYAWVYYHMGRLSDVQIYVDKVKHVCEKFSSPYRie 134
Cdd:COG0457   46 YNLGLAYLRLGRYEEALADYEQALEL---------DPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALY-- 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 135 speldcEEGWTRLKCGgnQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWPPSQNAIDPLRQAIRLNPDNQYLKVL 214
Cdd:COG0457  115 ------NLGLALLELG--RYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEA 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 153082755 215 LALKLHKMREEGEEEGEGEKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKA 273
Cdd:COG0457  187 ALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYRA 245
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 198-359 5.38e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 40.71  E-value: 5.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 198 LRQAIRLNPDNQYLKVLLALKLHKMREEGEEEGEGEKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYI 277
Cdd:COG5010    5 EGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 278 PNNAYLHCQIGCCYrakvfqvmnlRENGMYGKrkllelighAVAHLKKADEANDNLFRVCSILASLHALADQYEDAEYYF 357
Cdd:COG5010   85 PNNPELYYNLALLY----------SRSGDKDE---------AKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAAL 145


                 ..
gi 153082755 358 QK 359
Cdd:COG5010  146 QR 147
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 248-359 1.41e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.02  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 248 DVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYRAKvfqvmnlrenGMYGKrkllelighAVAHLKKAD 327
Cdd:COG4783    5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQL----------GDLDE---------AIVLLHEAL 65

                         90       100       110
                 ....*....|....*....|....*....|..
gi 153082755 328 EANDNLFRVCSILASLHALADQYEDAEYYFQK 359
Cdd:COG4783   66 ELDPDEPEARLNLGLALLKAGDYDEALALLEK 97
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
194-279 1.90e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 194 AIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEGegeklVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKA 273
Cdd:COG3063   11 AEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-----LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERA 85


                 ....*.
gi 153082755 274 LEYIPN 279
Cdd:COG3063   86 LELDPS 91
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
161-275 2.54e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.51  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 161 FEKALEKKPKNPEFTSGLAIASYRLDNWppsQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMReegeeegegEKLVEEAL 240
Cdd:COG4785  130 FDRALELDPDYAYAYLNRGIALYYLGRY---ELAIADLEKALELDPNDPERALWLYLAERKLD---------PEKALALL 197

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 153082755 241 EKAPgvtdvlrsaAKFYRRKDEPDKAIELLKKALE 275
Cdd:COG4785  198 LEDW---------ATAYLLQGDTEEARELFKLALA 223
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
152-244 2.62e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.07  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 152 NQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWppsQNAIDpLRQAIRLNPDNQYLKVLLALKLHKMReegeEEGE 231
Cdd:COG3063    6 GDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRY---DEAIA-LEKALKLDPNNAEALLNLAELLLELG----DYDE 77

                         90
                 ....*....|...
gi 153082755 232 GEKLVEEALEKAP 244
Cdd:COG3063   78 ALAYLERALELDP 90
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
257-359 2.67e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.07  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153082755 257 YRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYrakvfqvmnlRENGMYGKrkllelighAVAhLKKADEANDNLFRV 336
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLL----------LEQGRYDE---------AIA-LEKALKLDPNNAEA 61

                         90       100
                 ....*....|....*....|...
gi 153082755 337 CSILASLHALADQYEDAEYYFQK 359
Cdd:COG3063   62 LLNLAELLLELGDYDEALAYLER 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH