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Conserved domains on  [gi|2174213384|ref|NP_001386367|]
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coatomer subunit epsilon [Rattus norvegicus]

Protein Classification

coatomer subunit epsilon( domain architecture ID 12057363)

coatomer subunit epsilon, a component of the coatomer complex, which is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins

CATH:  1.25.40.10
Gene Ontology:  GO:0015031|GO:0005198|GO:0006888
PubMed:  20579721
SCOP:  4001344

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Coatomer_E pfam04733
Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, ...
 17-305 3.05e-153

Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, which is involved in the regulation of intracellular protein trafficking between the endoplasmic reticulum and the Golgi complex.


:

Pssm-ID: 398419 [Multi-domain]  Cd Length: 288  Bit Score: 430.36  E-value: 3.05e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384  17 DELFDVKNAFYIGSYQQCINEAQrVKLSSPEREVERDVFLYRAYLAQRKYGVVLDEIKPSSAPELQAVRMFAEYLASENR 96
Cdd:pfam04733   1 DELFNVRNYFYLGNYQKAINESD-VTSLSEEALVERDVYMYRSYLALGSYQIVISEIKESAATPLQAVRLLAEYLNSPSR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384  97 RDSIVLELDREMSRSVDVTNTTFLLMAASIYFHDQNPDAALRTLHQGDGLECTAMTIQILLKLDRLDLARKELKRMQEQD 176
Cdd:pfam04733  80 KESILASLKEWVADSHIGSNSTLRLLAAIIFIHEGDFDDALKHLHKGENLEAMALNVQILLKMHRIDLAEQQLKKMQQID 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 177 EDATLTQLATAWVNLAMGGEKLQEAYYIFQELADKCSPTLLLLNGQAACHSAQGRWETAEGVLQEALDKDSGHPETLINL 256
Cdd:pfam04733 160 EDATLTQLANAWVKLAVGGEKIQDAYYIFQEFSEKYDSTPLLLNGQAVCCMCLGRYEEAESLLKEALDKDAKDPETLINL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2174213384 257 IVLSQHLGKPPEVTNRYLSQLKDAHRTHPFIKEYQAKENDFDRLALQYA 305
Cdd:pfam04733 240 VVCALHLGKPAEVSNRNLSQLKLSHPTHPLVKDLNEKEAEFDRAVQQFA 288
 
Name Accession Description Interval E-value
Coatomer_E pfam04733
Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, ...
 17-305 3.05e-153

Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, which is involved in the regulation of intracellular protein trafficking between the endoplasmic reticulum and the Golgi complex.


Pssm-ID: 398419 [Multi-domain]  Cd Length: 288  Bit Score: 430.36  E-value: 3.05e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384  17 DELFDVKNAFYIGSYQQCINEAQrVKLSSPEREVERDVFLYRAYLAQRKYGVVLDEIKPSSAPELQAVRMFAEYLASENR 96
Cdd:pfam04733   1 DELFNVRNYFYLGNYQKAINESD-VTSLSEEALVERDVYMYRSYLALGSYQIVISEIKESAATPLQAVRLLAEYLNSPSR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384  97 RDSIVLELDREMSRSVDVTNTTFLLMAASIYFHDQNPDAALRTLHQGDGLECTAMTIQILLKLDRLDLARKELKRMQEQD 176
Cdd:pfam04733  80 KESILASLKEWVADSHIGSNSTLRLLAAIIFIHEGDFDDALKHLHKGENLEAMALNVQILLKMHRIDLAEQQLKKMQQID 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 177 EDATLTQLATAWVNLAMGGEKLQEAYYIFQELADKCSPTLLLLNGQAACHSAQGRWETAEGVLQEALDKDSGHPETLINL 256
Cdd:pfam04733 160 EDATLTQLANAWVKLAVGGEKIQDAYYIFQEFSEKYDSTPLLLNGQAVCCMCLGRYEEAESLLKEALDKDAKDPETLINL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2174213384 257 IVLSQHLGKPPEVTNRYLSQLKDAHRTHPFIKEYQAKENDFDRLALQYA 305
Cdd:pfam04733 240 VVCALHLGKPAEVSNRNLSQLKLSHPTHPLVKDLNEKEAEFDRAVQQFA 288
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 82-278 2.09e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384  82 QAVRMFAEYLASENRRDSIVLEL----------DR-----EMSRSVDVTNTTFLLMAASIYFHDQNPDAALRTLHQ---- 142
Cdd:COG2956    60 RAIRIHQKLLERDPDRAEALLELaqdylkagllDRaeellEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERllkl 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 143 -GDGLECTAMTIQILLKLDRLDLARKELKRMQEQDEDATLTQLATAwvNLAMGGEKLQEAYYIFQELADKCSPTLLLLNG 221
Cdd:COG2956   140 gPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLA--ELYLEQGDYEEAIAALERALEQDPDYLPALPR 217

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2174213384 222 QAACHSAQGRWETAEGVLQEALDKDSGHPEtLINLIVLSQHLGKPPEVTNRYLSQLK 278
Cdd:COG2956   218 LAELYEKLGDPEEALELLRKALELDPSDDL-LLALADLLERKEGLEAALALLERQLR 273
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 120-256 4.55e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 4.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 120 LLMAASIYFHDQNPDAALRTL-----HQGDGLECTAMTIQILLKLDRLDLARKELKRMQEQDEDATLTQLATAWVNLAMG 194
Cdd:TIGR02917 638 LLLLADAYAVMKNYAKAITSLkraleLKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQK 717

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2174213384 195 GEKLQEAYYifqELADKCSPTLLLLNGQAACHSAQGRWETAEGVLQEALDKDSGHPETLINL 256
Cdd:TIGR02917 718 DYPAAIQAY---RKALKRAPSSQNAIKLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTAL 776
 
Name Accession Description Interval E-value
Coatomer_E pfam04733
Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, ...
 17-305 3.05e-153

Coatomer epsilon subunit; This family represents the epsilon subunit of the coatomer complex, which is involved in the regulation of intracellular protein trafficking between the endoplasmic reticulum and the Golgi complex.


Pssm-ID: 398419 [Multi-domain]  Cd Length: 288  Bit Score: 430.36  E-value: 3.05e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384  17 DELFDVKNAFYIGSYQQCINEAQrVKLSSPEREVERDVFLYRAYLAQRKYGVVLDEIKPSSAPELQAVRMFAEYLASENR 96
Cdd:pfam04733   1 DELFNVRNYFYLGNYQKAINESD-VTSLSEEALVERDVYMYRSYLALGSYQIVISEIKESAATPLQAVRLLAEYLNSPSR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384  97 RDSIVLELDREMSRSVDVTNTTFLLMAASIYFHDQNPDAALRTLHQGDGLECTAMTIQILLKLDRLDLARKELKRMQEQD 176
Cdd:pfam04733  80 KESILASLKEWVADSHIGSNSTLRLLAAIIFIHEGDFDDALKHLHKGENLEAMALNVQILLKMHRIDLAEQQLKKMQQID 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 177 EDATLTQLATAWVNLAMGGEKLQEAYYIFQELADKCSPTLLLLNGQAACHSAQGRWETAEGVLQEALDKDSGHPETLINL 256
Cdd:pfam04733 160 EDATLTQLANAWVKLAVGGEKIQDAYYIFQEFSEKYDSTPLLLNGQAVCCMCLGRYEEAESLLKEALDKDAKDPETLINL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 2174213384 257 IVLSQHLGKPPEVTNRYLSQLKDAHRTHPFIKEYQAKENDFDRLALQYA 305
Cdd:pfam04733 240 VVCALHLGKPAEVSNRNLSQLKLSHPTHPLVKDLNEKEAEFDRAVQQFA 288
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 82-278 2.09e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384  82 QAVRMFAEYLASENRRDSIVLEL----------DR-----EMSRSVDVTNTTFLLMAASIYFHDQNPDAALRTLHQ---- 142
Cdd:COG2956    60 RAIRIHQKLLERDPDRAEALLELaqdylkagllDRaeellEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERllkl 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 143 -GDGLECTAMTIQILLKLDRLDLARKELKRMQEQDEDATLTQLATAwvNLAMGGEKLQEAYYIFQELADKCSPTLLLLNG 221
Cdd:COG2956   140 gPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLA--ELYLEQGDYEEAIAALERALEQDPDYLPALPR 217

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2174213384 222 QAACHSAQGRWETAEGVLQEALDKDSGHPEtLINLIVLSQHLGKPPEVTNRYLSQLK 278
Cdd:COG2956   218 LAELYEKLGDPEEALELLRKALELDPSDDL-LLALADLLERKEGLEAALALLERQLR 273
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 154-273 2.06e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.34  E-value: 2.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 154 QILLKLDRLDLARKELKRMQEQDEDATLTQLATAWVNLAMGgeKLQEAYYIFQELADKCSPTLLLLNGQAACHSAQGRWE 233
Cdd:COG4783    12 QALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLG--DLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 2174213384 234 TAEGVLQEALDKDSGHPETLINLIVLSQHLGKPPEVTNRY 273
Cdd:COG4783    90 EALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAAL 129
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 112-304 3.77e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.42  E-value: 3.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 112 VDVTNTTFLLMAASIYFHDQNPDAALRTLHQ-----GDGLECTAMTIQILLKLDRLDLARKELKRMQEQDEDATltQLAT 186
Cdd:COG2956    37 LDPETVEAHLALGNLYRRRGEYDRAIRIHQKllerdPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDA--EALR 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 187 AWVNLAMGGEKLQEAYYIFQELADKCSPTLLLLNGQAACHSAQGRWETAEGVLQEALDKDSGHPETLINLIVLSQHLGKP 266
Cdd:COG2956   115 LLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDY 194

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2174213384 267 PEVTNRYLSQLK---DAHRTHPFIKEYQAKENDFDRLALQY 304
Cdd:COG2956   195 EEAIAALERALEqdpDYLPALPRLAELYEKLGDPEEALELL 235
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 153-268 1.05e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.91  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 153 IQILLKLDRLDLARKELKRMQEQDEDatltqLATAWVNLA---MGGEKLQEAYYIFQELADKCSPTLLLLNGQAACHSAQ 229
Cdd:COG3914    85 ALLLQALGRYEEALALYRRALALNPD-----NAEALFNLGnllLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRL 159

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2174213384 230 GRWETAEGVLQEALDKDSGHPETLINLIVLSQHLGKPPE 268
Cdd:COG3914   160 GRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEE 198
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 154-304 3.21e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.72  E-value: 3.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 154 QILLKLDRLDLARKELKRMQEQDEDATLTQLATAwvNLAMGGEKLQEAYYIFQELADKCSPTLLLLNGQAACHSAQGRWE 233
Cdd:COG2956    16 LNYLLNGQPDKAIDLLEEALELDPETVEAHLALG--NLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLD 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2174213384 234 TAEGVLQEALDKDSGHPETLINLIVLSQHLGKPP---EVTNRYLSQLKDAHRTHPFIKEYQAKENDFDRlALQY 304
Cdd:COG2956    94 RAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEkaiEVLERLLKLGPENAHAYCELAELYLEQGDYDE-AIEA 166
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 120-268 1.20e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.44  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 120 LLMAASIYFHDQNPDAALRTLHQGDGLECTAMTIQILLKLDRLDLARKELKRMQEQDEDATLTQLAtawvnlamggEKLQ 199
Cdd:COG3914    26 LALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQAL----------GRYE 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2174213384 200 EAYYIFQELADKCSPTLLLLNGQAACHSAQGRWETAEGVLQEALDKDSGHPETLINLIVLSQHLGKPPE 268
Cdd:COG3914    96 EALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEE 164
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
155-268 1.29e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.60  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 155 ILLKLDRLDLARKELKRMQEQDEDATLTQLATAWVNLAMGgeKLQEAYYIFQELADKCSPTLLLLNGQAACHSAQGRWET 234
Cdd:COG0457    17 AYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLG--RYEEALADYEQALELDPDDAEALNNLGLALQALGRYEE 94

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2174213384 235 AEGVLQEALDKDSGHPETLINLIVLSQHLGKPPE 268
Cdd:COG0457    95 ALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
154-305 1.89e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.22  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 154 QILLKLDRLDLARKELKRMQEQDEDatltqLATAWVNLAM---GGEKLQEAYYIFQELADKCSPTLLLLNGQAACHSAQG 230
Cdd:COG0457    50 LAYLRLGRYEEALADYEQALELDPD-----DAEALNNLGLalqALGRYEEALEDYDKALELDPDDAEALYNLGLALLELG 124

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2174213384 231 RWETAEGVLQEALDKDSGHPETLINLIVLSQHLGKPPEVTNRYLSQLKDAHRTHPFIKEYQAKENDFDRLALQYA 305
Cdd:COG0457   125 RYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 116-246 2.80e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.56  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 116 NTTFLLMAASIYFHDQNPDAALRTLHQG-----DGLECTAMTIQILLKLDRLDLARKELKRMQEQDEDATLTQLATAWVN 190
Cdd:COG2956   143 NAHAYCELAELYLEQGDYDEAIEALEKAlkldpDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELY 222

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2174213384 191 LAMGgeKLQEAYYIFQELADKcSPTLLLLNGQAACHSAQGRWETAEGVLQEALDKD 246
Cdd:COG2956   223 EKLG--DPEEALELLRKALEL-DPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 120-256 4.55e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 4.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2174213384 120 LLMAASIYFHDQNPDAALRTL-----HQGDGLECTAMTIQILLKLDRLDLARKELKRMQEQDEDATLTQLATAWVNLAMG 194
Cdd:TIGR02917 638 LLLLADAYAVMKNYAKAITSLkraleLKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQK 717

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2174213384 195 GEKLQEAYYifqELADKCSPTLLLLNGQAACHSAQGRWETAEGVLQEALDKDSGHPETLINL 256
Cdd:TIGR02917 718 DYPAAIQAY---RKALKRAPSSQNAIKLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTAL 776
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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