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Conserved domains on  [gi|2071063211|ref|NP_001382548|]
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uncharacterized protein LOC502617 [Rattus norvegicus]

Protein Classification

divalent-cation tolerance protein CutA( domain architecture ID 10503769)

divalent-cation tolerance protein CutA is a cytoplasmic protein implicated in regulating intracellular metal homeostasis

CATH:  3.30.70.120
Gene Symbol:  cutA
Gene Ontology:  GO:0010038
SCOP:  4002632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CutA1 pfam03091
CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in ...
 56-152 3.76e-43

CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).


:

Pssm-ID: 460800  Cd Length: 98  Bit Score: 137.97  E-value: 3.76e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2071063211  56 IVFVNCPNEQIARDIARTILDKKMAASVNILPKISTLYFWKGEIEEGTEVSLLIKTKTSKVPWLFAYMRLTHPFEVPEIF 135
Cdd:pfam03091   1 LVYTTAPDEEEAEKIARALVEERLAACVNILPGITSIYRWEGKIEEDEEVLLLIKTRASLVDALEARIRELHPYEVPEII 80

                          90
                  ....*....|....*..
gi 2071063211 136 SIPMDQGDTRYLKWLEE 152
Cdd:pfam03091  81 ALPIEAGNPDYLDWIRE 97
 
Name Accession Description Interval E-value
CutA1 pfam03091
CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in ...
 56-152 3.76e-43

CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).


Pssm-ID: 460800  Cd Length: 98  Bit Score: 137.97  E-value: 3.76e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2071063211  56 IVFVNCPNEQIARDIARTILDKKMAASVNILPKISTLYFWKGEIEEGTEVSLLIKTKTSKVPWLFAYMRLTHPFEVPEIF 135
Cdd:pfam03091   1 LVYTTAPDEEEAEKIARALVEERLAACVNILPGITSIYRWEGKIEEDEEVLLLIKTRASLVDALEARIRELHPYEVPEII 80

                          90
                  ....*....|....*..
gi 2071063211 136 SIPMDQGDTRYLKWLEE 152
Cdd:pfam03091  81 ALPIEAGNPDYLDWIRE 97
CutA1 COG1324
Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];
53-152 8.54e-40

Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];


Pssm-ID: 440935  Cd Length: 104  Bit Score: 129.92  E-value: 8.54e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2071063211  53 SYSIVFVNCPNEQIARDIARTILDKKMAASVNILPKISTLYFWKGEIEEGTEVSLLIKTKTSKVPWLFAYMRLTHPFEVP 132
Cdd:COG1324     2 DYILVLTTAPDEEEAERIARALVEERLAACVNILPPITSVYRWQGKIEEDEEVLLLIKTTAERYDALEARIKELHPYEVP 81

                          90       100
                  ....*....|....*....|
gi 2071063211 133 EIFSIPMDQGDTRYLKWLEE 152
Cdd:COG1324    82 EIIALPIEAGNPAYLDWIRE 101
dival_cat_tol_CutA NF041095
divalent-cation tolerance protein CutA;
56-152 4.22e-30

divalent-cation tolerance protein CutA;


Pssm-ID: 469021  Cd Length: 100  Bit Score: 105.03  E-value: 4.22e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2071063211  56 IVFVNCPNEQIARDIARTILDKKMAASVNILPkISTLYFWKGEIEEGTEVSLLIKTKTSKVPWLFAYMRLTHPFEVPEIF 135
Cdd:NF041095    3 LVYTTFPDEESAKEIARKLLEERLIACVNLRE-IRSMYWWKGKIEEDKEVGAILKTTKERWEELKEELKELHPYEVPAIL 81

                          90
                  ....*....|....*..
gi 2071063211 136 SIPMDQGDTRYLKWLEE 152
Cdd:NF041095   82 VIEVEDVNKEYLSWLDE 98
PRK10645 PRK10645
divalent cation tolerance protein CutA;
56-150 6.48e-26

divalent cation tolerance protein CutA;


Pssm-ID: 182614  Cd Length: 112  Bit Score: 94.84  E-value: 6.48e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2071063211  56 IVFVNCPNEQIARDIARTILDKKMAASVNILPKISTLYFWKGEIEEGTEVSLLIKTKTSKVPWLFAYMRLTHPFEVPEIF 135
Cdd:PRK10645   13 VVLCTAPDEATAQDLAAKVLAEKLAACVTLLPGATSLYYWEGKLEQEYEVQMLLKTTVSHQQALLECLKSHHPYQTPELL 92

                          90
                  ....*....|....*
gi 2071063211 136 SIPMDQGDTRYLKWL 150
Cdd:PRK10645   93 VLPVTHGDTDYLSWL 107
 
Name Accession Description Interval E-value
CutA1 pfam03091
CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in ...
 56-152 3.76e-43

CutA1 divalent ion tolerance protein; Several gene loci with a possible involvement in cellular tolerance to copper have been identified. One such locus in eubacteria and archaebacteria, cutA, is thought to be involved in cellular tolerance to a wide variety of divalent cations other than copper. The cutA locus consists of two operons, of one and two genes. The CutA1 protein is a cytoplasmic protein, encoded by the single-gene operon and has been linked to divalent cation tolerance. It has no recognized structural motifs. This family also contains putative proteins from eukaryotes (human and Drosophila).


Pssm-ID: 460800  Cd Length: 98  Bit Score: 137.97  E-value: 3.76e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2071063211  56 IVFVNCPNEQIARDIARTILDKKMAASVNILPKISTLYFWKGEIEEGTEVSLLIKTKTSKVPWLFAYMRLTHPFEVPEIF 135
Cdd:pfam03091   1 LVYTTAPDEEEAEKIARALVEERLAACVNILPGITSIYRWEGKIEEDEEVLLLIKTRASLVDALEARIRELHPYEVPEII 80

                          90
                  ....*....|....*..
gi 2071063211 136 SIPMDQGDTRYLKWLEE 152
Cdd:pfam03091  81 ALPIEAGNPDYLDWIRE 97
CutA1 COG1324
Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];
53-152 8.54e-40

Divalent cation tolerance protein CutA [Inorganic ion transport and metabolism];


Pssm-ID: 440935  Cd Length: 104  Bit Score: 129.92  E-value: 8.54e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2071063211  53 SYSIVFVNCPNEQIARDIARTILDKKMAASVNILPKISTLYFWKGEIEEGTEVSLLIKTKTSKVPWLFAYMRLTHPFEVP 132
Cdd:COG1324     2 DYILVLTTAPDEEEAERIARALVEERLAACVNILPPITSVYRWQGKIEEDEEVLLLIKTTAERYDALEARIKELHPYEVP 81

                          90       100
                  ....*....|....*....|
gi 2071063211 133 EIFSIPMDQGDTRYLKWLEE 152
Cdd:COG1324    82 EIIALPIEAGNPAYLDWIRE 101
dival_cat_tol_CutA NF041095
divalent-cation tolerance protein CutA;
56-152 4.22e-30

divalent-cation tolerance protein CutA;


Pssm-ID: 469021  Cd Length: 100  Bit Score: 105.03  E-value: 4.22e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2071063211  56 IVFVNCPNEQIARDIARTILDKKMAASVNILPkISTLYFWKGEIEEGTEVSLLIKTKTSKVPWLFAYMRLTHPFEVPEIF 135
Cdd:NF041095    3 LVYTTFPDEESAKEIARKLLEERLIACVNLRE-IRSMYWWKGKIEEDKEVGAILKTTKERWEELKEELKELHPYEVPAIL 81

                          90
                  ....*....|....*..
gi 2071063211 136 SIPMDQGDTRYLKWLEE 152
Cdd:NF041095   82 VIEVEDVNKEYLSWLDE 98
PRK10645 PRK10645
divalent cation tolerance protein CutA;
56-150 6.48e-26

divalent cation tolerance protein CutA;


Pssm-ID: 182614  Cd Length: 112  Bit Score: 94.84  E-value: 6.48e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2071063211  56 IVFVNCPNEQIARDIARTILDKKMAASVNILPKISTLYFWKGEIEEGTEVSLLIKTKTSKVPWLFAYMRLTHPFEVPEIF 135
Cdd:PRK10645   13 VVLCTAPDEATAQDLAAKVLAEKLAACVTLLPGATSLYYWEGKLEQEYEVQMLLKTTVSHQQALLECLKSHHPYQTPELL 92

                          90
                  ....*....|....*
gi 2071063211 136 SIPMDQGDTRYLKWL 150
Cdd:PRK10645   93 VLPVTHGDTDYLSWL 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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