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Conserved domains on  [gi|2070421327|ref|NP_001382501|]
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highly divergent homeobox isoform 2 [Rattus norvegicus]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10052840)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Gene Ontology:  GO:0003677|GO:0006357|GO:0043565
PubMed:  1357790|26464018|21557080

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 383-439 5.45e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 41.07  E-value: 5.45e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2070421327 383 RTQFSDRDLATLKKYWDNGMTslgsVCREKIEAVATELNVDCEIVRTWIGNRRRKYR 439
Cdd:cd00086     4 RTRFTPEQLEELEKEFEKNPY----PSREEREELAKELGLTERQVKIWFQNRRAKLK 56
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 383-439 5.45e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 41.07  E-value: 5.45e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2070421327 383 RTQFSDRDLATLKKYWDNGMTslgsVCREKIEAVATELNVDCEIVRTWIGNRRRKYR 439
Cdd:cd00086     4 RTRFTPEQLEELEKEFEKNPY----PSREEREELAKELGLTERQVKIWFQNRRAKLK 56
Homeodomain pfam00046
Homeodomain;
383-439 2.99e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 39.02  E-value: 2.99e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2070421327 383 RTQFSDRDLATLKKYWDNGMTslgsVCREKIEAVATELNVDCEIVRTWIGNRRRKYR 439
Cdd:pfam00046   4 RTTFTPEQLEELEKEFQENPY----PSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 383-439 8.02e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 38.00  E-value: 8.02e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2070421327  383 RTQFSDRDLATLKKYWDNGMTslgsVCREKIEAVATELNVDCEIVRTWIGNRRRKYR 439
Cdd:smart00389   5 RTSFTPEQLEELEKEFQKNPY----PSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
 
Name Accession Description Interval E-value
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 383-439 5.45e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 41.07  E-value: 5.45e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2070421327 383 RTQFSDRDLATLKKYWDNGMTslgsVCREKIEAVATELNVDCEIVRTWIGNRRRKYR 439
Cdd:cd00086     4 RTRFTPEQLEELEKEFEKNPY----PSREEREELAKELGLTERQVKIWFQNRRAKLK 56
Homeodomain pfam00046
Homeodomain;
383-439 2.99e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 39.02  E-value: 2.99e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2070421327 383 RTQFSDRDLATLKKYWDNGMTslgsVCREKIEAVATELNVDCEIVRTWIGNRRRKYR 439
Cdd:pfam00046   4 RTTFTPEQLEELEKEFQENPY----PSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 383-439 8.02e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 38.00  E-value: 8.02e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2070421327  383 RTQFSDRDLATLKKYWDNGMTslgsVCREKIEAVATELNVDCEIVRTWIGNRRRKYR 439
Cdd:smart00389   5 RTSFTPEQLEELEKEFQKNPY----PSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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