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Conserved domains on  [gi|2048774921|ref|NP_001382067|]
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zinc finger protein 40 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
42-84 9.71e-21

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 9.71e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2048774921   42 LTFRNVAVDFSKEEWEYLDSSQRALYMDVMWENYSNLVFVENH 84
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-678 1.21e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 278 KPYKCIECGKCNYHSSGFERHYRIHTGEETYKCYD--CRKSFICYLGLKNHHKIHGGERPYECKQCSKS--FYTLSHLEN 353
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 354 HYRTHRrqklhrcNECGKSLSSSSGLQRHQRIHRGEKAyicaecdKCFIQKSQLKTHQKIHTGEKSYKCS-------ECE 426
Cdd:COG5048   112 SSSSNS-------NDNNLLSSHSLPPSSRDPQLPDLLS-------ISNLRNNPLPGNNSSSVNTPQSNSLhpplpanSLS 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 427 KSFTVGSSLRIHQRIHTGEKPYKCSECHKCFIQQAHLRRHQKIHTGEKPYKCSECEKSFTVGSDLRMHQKIHTGEKPYKC 506
Cdd:COG5048   178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 507 SDCDKCFIQKAKLKKHQRIHTGE-------KPYKCSECEKCFTVVSDLRTHQ--KIHTGE--KPYKCSE--CDKCFIRKA 573
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 574 NLRRHHRIHTGEKPYKC--SDCGKCFIQKANLRTHERI--HTGEKPYKCECG------KSFSVGSDLRKHQKCHTGEKP- 642
Cdd:COG5048   338 ALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETlsnsciRNFKRDSNLSLHIITHLSFRPy 417

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 2048774921 643 -YKCSECHKCFIRKAHLRRHQRIHTGEKPYKCSDCGK 678
Cdd:COG5048   418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
685-710 1.44e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|....*.
gi 2048774921 685 NLRTHQKIHTGEKPYKCSDCDKCFIQ 710
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
713-737 2.31e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.31e-03
                          10        20
                  ....*....|....*....|....*
gi 2048774921 713 HLRTHQRLHTGEKPYKCSECEKSFT 737
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
42-84 9.71e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 9.71e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2048774921   42 LTFRNVAVDFSKEEWEYLDSSQRALYMDVMWENYSNLVFVENH 84
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 42-81 5.89e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.29  E-value: 5.89e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2048774921  42 LTFRNVAVDFSKEEWEYLDSSQRALYMDVMWENYSNLVFV 81
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 42-80 2.06e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 2.06e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2048774921  42 LTFRNVAVDFSKEEWEYLDSSQRALYMDVMWENYSNLVF 80
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-678 1.21e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 278 KPYKCIECGKCNYHSSGFERHYRIHTGEETYKCYD--CRKSFICYLGLKNHHKIHGGERPYECKQCSKS--FYTLSHLEN 353
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 354 HYRTHRrqklhrcNECGKSLSSSSGLQRHQRIHRGEKAyicaecdKCFIQKSQLKTHQKIHTGEKSYKCS-------ECE 426
Cdd:COG5048   112 SSSSNS-------NDNNLLSSHSLPPSSRDPQLPDLLS-------ISNLRNNPLPGNNSSSVNTPQSNSLhpplpanSLS 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 427 KSFTVGSSLRIHQRIHTGEKPYKCSECHKCFIQQAHLRRHQKIHTGEKPYKCSECEKSFTVGSDLRMHQKIHTGEKPYKC 506
Cdd:COG5048   178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 507 SDCDKCFIQKAKLKKHQRIHTGE-------KPYKCSECEKCFTVVSDLRTHQ--KIHTGE--KPYKCSE--CDKCFIRKA 573
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 574 NLRRHHRIHTGEKPYKC--SDCGKCFIQKANLRTHERI--HTGEKPYKCECG------KSFSVGSDLRKHQKCHTGEKP- 642
Cdd:COG5048   338 ALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETlsnsciRNFKRDSNLSLHIITHLSFRPy 417

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 2048774921 643 -YKCSECHKCFIRKAHLRRHQRIHTGEKPYKCSDCGK 678
Cdd:COG5048   418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-486 3.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.65e-04
                          10        20
                  ....*....|....*....|....*
gi 2048774921 462 HLRRHQKIHTGEKPYKCSECEKSFT 486
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
685-710 1.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|....*.
gi 2048774921 685 NLRTHQKIHTGEKPYKCSDCDKCFIQ 710
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
713-737 2.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.31e-03
                          10        20
                  ....*....|....*....|....*
gi 2048774921 713 HLRTHQRLHTGEKPYKCSECEKSFT 737
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
42-84 9.71e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 9.71e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2048774921   42 LTFRNVAVDFSKEEWEYLDSSQRALYMDVMWENYSNLVFVENH 84
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 42-81 5.89e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.29  E-value: 5.89e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2048774921  42 LTFRNVAVDFSKEEWEYLDSSQRALYMDVMWENYSNLVFV 81
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 42-80 2.06e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.05  E-value: 2.06e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2048774921  42 LTFRNVAVDFSKEEWEYLDSSQRALYMDVMWENYSNLVF 80
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-678 1.21e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 278 KPYKCIECGKCNYHSSGFERHYRIHTGEETYKCYD--CRKSFICYLGLKNHHKIHGGERPYECKQCSKS--FYTLSHLEN 353
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 354 HYRTHRrqklhrcNECGKSLSSSSGLQRHQRIHRGEKAyicaecdKCFIQKSQLKTHQKIHTGEKSYKCS-------ECE 426
Cdd:COG5048   112 SSSSNS-------NDNNLLSSHSLPPSSRDPQLPDLLS-------ISNLRNNPLPGNNSSSVNTPQSNSLhpplpanSLS 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 427 KSFTVGSSLRIHQRIHTGEKPYKCSECHKCFIQQAHLRRHQKIHTGEKPYKCSECEKSFTVGSDLRMHQKIHTGEKPYKC 506
Cdd:COG5048   178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 507 SDCDKCFIQKAKLKKHQRIHTGE-------KPYKCSECEKCFTVVSDLRTHQ--KIHTGE--KPYKCSE--CDKCFIRKA 573
Cdd:COG5048   258 SESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRND 337

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 574 NLRRHHRIHTGEKPYKC--SDCGKCFIQKANLRTHERI--HTGEKPYKCECG------KSFSVGSDLRKHQKCHTGEKP- 642
Cdd:COG5048   338 ALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETlsnsciRNFKRDSNLSLHIITHLSFRPy 417

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 2048774921 643 -YKCSECHKCFIRKAHLRRHQRIHTGEKPYKCSDCGK 678
Cdd:COG5048   418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
334-717 1.21e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 1.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 334 RPYECKQCSKSFYTLSHLENHYRTHRRQKLHRCN--ECGKSLSSSSGLQRHQRIHRGEKAYICAecDKCFIQKSQLKTHQ 411
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 412 KIHTGEKSYKCSECEK------------SFTVGSSLRIHQRIHTGEKPYKCSECHKCFIQQAHLRRHQKIH--------- 470
Cdd:COG5048   110 LSSSSSNSNDNNLLSShslppssrdpqlPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPssnlsllis 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 471 ----TGEKPYKCSECEKSFTVGSDLRMHQKIHTGEKPYKCSDCDkcFIQKAKLKKHQRIHTGEKPYKCSECEKCFTVVSD 546
Cdd:COG5048   190 snvsTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 547 LRTHQKIHTG---------EKPYKCSECDKCFIRKANLRRH--HRIHTGE--KPYKC--SDCGKCFIQKANLRTHERIHT 611
Cdd:COG5048   268 ASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 612 GEKPYKC---ECGKSFSVGSDLRKHQKC--HTGEKPYKCSEC--HKCFI---RKAHLRRHQRIHTGEKP--YKCSDCGKC 679
Cdd:COG5048   348 SISPAKEkllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETlsNSCIRnfkRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 2048774921 680 FIQKANLRTHQKIHTGEKPYKCSDCDKcFIQKDHLRTH 717
Cdd:COG5048   428 FNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
446-767 2.17e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 446 KPYKCSECHKCFIQQAHLRRHQKIHTGEKPYKCS--ECEKSFTVGSDLRMHQKIHTGEKPYKCSdcDKCFIQKAKLKKHQ 523
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 524 RIHTGEKPYKCSECEKCftVVSDLRTHQKIHTGEKPYKCSECD------KCFIRKANLRRHHRIHTGEKpykcsdCGKCF 597
Cdd:COG5048   110 LSSSSSNSNDNNLLSSH--SLPPSSRDPQLPDLLSISNLRNNPlpgnnsSSVNTPQSNSLHPPLPANSL------SKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 598 IQKANLRTHERIHTGEKPYKCECGKSFSVGSDLRKHQKCHTGEKPYKCSECHKCF------------------------- 652
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqspsslsssdssssasesp 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 653 ---------IRKAHLRRHQRIHTG-EKPYKCSDCGKCFIQKANLRTHQ--KIHTGE--KPYKC--SDCDKCFIQKDHLRT 716
Cdd:COG5048   262 rsslptassQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKR 341

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2048774921 717 HQRLHTGEKPYKC--SECEKSFTGGSILRKHQKIHTARSLTNAMNLTNPLSKK 767
Cdd:COG5048   342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSC 394
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-595 3.10e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 3.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 203 DRFFDSKHKLMIKRMCSGEKPYQCRK--CGKCFRAYSSLYRHRRTHPGEKTYKLTECNKSILYF-SHQKVHYNIHYGEKP 279
Cdd:COG5048    41 DSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKaSSSSLSSSSSNSNDN 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 280 YKCIECGKCNYHSSGFERHYRIHTGEETYKCYDC-RKSFICYLGLKNHHKIHGGERPYECKQCSKSFYTLSHLENHYRT- 357
Cdd:COG5048   121 NLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSs 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 358 -----HRRQKLHRCNECGKSLSSSSGLQRHQRIHRGEKAYICAecdkcfiQKSQLKTHQKIHTGEKSYKCSECEKSFTVG 432
Cdd:COG5048   201 ensplSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ-------SPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 433 SSLRIHQRIHTG-EKPYKCSECHKCFIQQAHLRRHQ--KIHTGE--KPYKCSE--CEKSFTVGSDLRMHQKIHTGEKPYK 505
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 506 C--SDCDKCFIQKAKLKKHQRI--HTGEKPYKCSEC---EKCFTVVSD----LRTHQKIHTGEKPYKCSECDKCFIRKAN 574
Cdd:COG5048   354 EklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETlsnSCIRNFKRDsnlsLHIITHLSFRPYNCKNPPCSKSFNRHYN 433

                         410       420
                  ....*....|....*....|.
gi 2048774921 575 LRRHHRIHTGEKPYKCSDCGK 595
Cdd:COG5048   434 LIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
392-736 4.39e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 4.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 392 YICAECDKCFIQKSQLKTHQKIHTGEKSYKCS--ECEKSFTVGSSLRIHQRIHTGEKPYKCS----------------EC 453
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskasssslsSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 454 HKCFIQQ--------AHLRRHQKIHTGEKPYKCSECEK--------------SFTVGSDLRMHQKIHTGEK--------- 502
Cdd:COG5048   114 SSNSNDNnllsshslPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnSLHPPLPANSLSKDPSSNLsllissnvs 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 503 -PYKCSDCDKCFIQKAKLKKHQRIHTGEKPYKCSECEKCFTVVSDLRTHQKIHTGEKPYKCSECDKCFIR---KANLRRH 578
Cdd:COG5048   194 tSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSslpTASSQSS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 579 HRIHTGE-------KPYKCSDCGKCFIQKANLRTHER--IHTGE--KPYKCE---CGKSFSVGSDLRKHQKCHTGEKPYK 644
Cdd:COG5048   274 SPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPyslCGKLFSRNDALKRHILLHTSISPAK 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 645 CSECH------KCFIRKAHLRRHQRIHTGEKPYKCSDCGKCFI---QKANLRTHQKIHTGEKP--YKCSDCDKCFIQKDH 713
Cdd:COG5048   354 EKLLNssskfsPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRnfkRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433

                         410       420
                  ....*....|....*....|...
gi 2048774921 714 LRTHQRLHTGEKPYKCSECEKSF 736
Cdd:COG5048   434 LIPHKKIHTNHAPLLCSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-486 3.65e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.65e-04
                          10        20
                  ....*....|....*....|....*
gi 2048774921 462 HLRRHQKIHTGEKPYKCSECEKSFT 486
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
657-682 3.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.72e-04
                          10        20
                  ....*....|....*....|....*.
gi 2048774921 657 HLRRHQRIHTGEKPYKCSDCGKCFIQ 682
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-599 6.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.57e-04
                          10        20
                  ....*....|....*....|....*.
gi 2048774921 574 NLRRHHRIHTGEKPYKCSDCGKCFIQ 599
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 500-583 1.23e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 500 GEKPYKCS--DCDKCFIQKAKLKKHqRIHtgekpykcSECEKCFTVVSDLRTHQKIHTGEKPYKCSECDKCFiRKANLRR 577
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRY-KNLNGLK 415


                  ....*.
gi 2048774921 578 HHRIHT 583
Cdd:COG5189   416 YHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
685-710 1.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|....*.
gi 2048774921 685 NLRTHQKIHTGEKPYKCSDCDKCFIQ 710
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
546-571 1.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.99e-03
                          10        20
                  ....*....|....*....|....*.
gi 2048774921 546 DLRTHQKIHTGEKPYKCSECDKCFIR 571
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
713-737 2.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.31e-03
                          10        20
                  ....*....|....*....|....*
gi 2048774921 713 HLRTHQRLHTGEKPYKCSECEKSFT 737
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
519-542 2.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.43e-03
                          10        20
                  ....*....|....*....|....
gi 2048774921 519 LKKHQRIHTGEKPYKCSECEKCFT 542
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
490-515 2.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.47e-03
                          10        20
                  ....*....|....*....|....*.
gi 2048774921 490 DLRMHQKIHTGEKPYKCSDCDKCFIQ 515
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
434-459 2.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.90e-03
                          10        20
                  ....*....|....*....|....*.
gi 2048774921 434 SLRIHQRIHTGEKPYKCSECHKCFIQ 459
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
629-654 3.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.49e-03
                          10        20
                  ....*....|....*....|....*.
gi 2048774921 629 DLRKHQKCHTGEKPYKCSECHKCFIR 654
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 465-552 5.94e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 5.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2048774921 465 RHQKIhTGEKPYKCS--ECEKSFTVGSDLRMHQKI-HTGEKPYKCSDCDKcfiqkaklkkHQRIHTGEKPYKCSECEKCF 541
Cdd:COG5189   340 RMLKV-KDGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRY 408

                          90
                  ....*....|.
gi 2048774921 542 TVVSDLRTHQK 552
Cdd:COG5189   409 KNLNGLKYHRK 419
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 643-665 7.39e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.39e-03
                          10        20
                  ....*....|....*....|...
gi 2048774921 643 YKCSECHKCFIRKAHLRRHQRIH 665
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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