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Conserved domains on  [gi|2035253171|ref|NP_001381857|]
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integrin alpha-6 isoform 6 precursor [Homo sapiens]

Protein Classification

integrin alpha( domain architecture ID 12192630)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

CATH:  2.130.10.130|2.60.40.1510|2.60.40.1530|2.60.40.1460
Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368
SCOP:  4003137

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 504-978 2.05e-173

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 516.87  E-value: 2.05e-173
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  504 RPVINIQKTITVTPNRIDLRQKTaCGAPSG--ICLQVKSCFEYTANPAgYNPSISIVGTLEAEKERRKsGLSSRVQFrNQ 581
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKN-CTLTGTpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLF-LD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  582 GSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPssRRRVNSLPEVLPILNSDEPKTAHIDVHFL 661
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVD--PRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  662 KEgCGDDNVCNSNLKLEYKFCTREGNqdkfsylpiqkgvPELVLKDQKDIALEITVTNspsnprnptkDGDDAHEAKLIA 741
Cdd:pfam08441  155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTN----------LGEDAYEAELYV 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  742 TFPDTLTYSAYRelRAFPEKQLSCVANQNGS--QADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQD 819
Cdd:pfam08441  211 TLPPGLDYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQN 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  820 -NLAPITAKAKVVIELLLSVSGVAKPSQVyFGGTVVGEQAMK--SEDEVGSLIEYEFRVINLGKPltNLGTATLNIQWPK 896
Cdd:pfam08441  289 sNSNPVSLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPY 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  897 EISNGKWLLYLVKVEskGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQT----LNCSVNVN 972
Cdd:pfam08441  366 ELSNGKWLLYLLDVQ--GQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTasvlLSCDSGAR 443


                   ....*.
gi 2035253171  973 CVNIRC 978
Cdd:pfam08441  444 CVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 413-464 7.11e-15

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 69.71  E-value: 7.11e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2035253171   413 DSMFGIAVKNIGDINQDGYPDIAVGAPYDD----LGKVFIYHGSANGINTKPTQVL 464
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 353-406 5.65e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 5.65e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2035253171   353 SSFGYDVA-VVDLNKDGWQDIVIGAPQYFdrDGEVGGAVYVYMNQQ--GRWNNVKPI 406
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFGSSggGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 40-100 1.95e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.91  E-value: 1.95e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2035253171    40 PGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEAlplqrANRTGGLYSCDITARG-PCTRIEFD 100
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRAND-----AGETGAVYVYFGSSGGgNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 293-345 3.75e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 39.67  E-value: 3.75e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2035253171   293 MNSYLGFSLDSGkGIVSKDEIT-FVSGAPRANHS---GAVVLLKRDMKSAHLLPEHI 345
Cdd:smart00191    1 PGSYFGYSVAGV-GDVNGDGYPdLLVGAPRANDAgetGAVYVYFGSSGGGNSIPLQN 56
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 470-493 2.85e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.85e-03
                            10        20
                    ....*....|....*....|....
gi 2035253171   470 YFGYSIAGNMDLDRNSYPDVAVGS 493
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGA 27
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 504-978 2.05e-173

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 516.87  E-value: 2.05e-173
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  504 RPVINIQKTITVTPNRIDLRQKTaCGAPSG--ICLQVKSCFEYTANPAgYNPSISIVGTLEAEKERRKsGLSSRVQFrNQ 581
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKN-CTLTGTpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLF-LD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  582 GSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPssRRRVNSLPEVLPILNSDEPKTAHIDVHFL 661
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVD--PRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  662 KEgCGDDNVCNSNLKLEYKFCTREGNqdkfsylpiqkgvPELVLKDQKDIALEITVTNspsnprnptkDGDDAHEAKLIA 741
Cdd:pfam08441  155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTN----------LGEDAYEAELYV 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  742 TFPDTLTYSAYRelRAFPEKQLSCVANQNGS--QADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQD 819
Cdd:pfam08441  211 TLPPGLDYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQN 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  820 -NLAPITAKAKVVIELLLSVSGVAKPSQVyFGGTVVGEQAMK--SEDEVGSLIEYEFRVINLGKPltNLGTATLNIQWPK 896
Cdd:pfam08441  289 sNSNPVSLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPY 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  897 EISNGKWLLYLVKVEskGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQT----LNCSVNVN 972
Cdd:pfam08441  366 ELSNGKWLLYLLDVQ--GQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTasvlLSCDSGAR 443


                   ....*.
gi 2035253171  973 CVNIRC 978
Cdd:pfam08441  444 CVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 413-464 7.11e-15

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 69.71  E-value: 7.11e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2035253171   413 DSMFGIAVKNIGDINQDGYPDIAVGAPYDD----LGKVFIYHGSANGINTKPTQVL 464
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 353-406 5.65e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 5.65e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2035253171   353 SSFGYDVA-VVDLNKDGWQDIVIGAPQYFdrDGEVGGAVYVYMNQQ--GRWNNVKPI 406
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFGSSggGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 355-393 8.30e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.82  E-value: 8.30e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2035253171  355 FGYDVAVVDLNKDGWQDIVIGAPQYFDRDgevGGAVYVY 393
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 40-100 1.95e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.91  E-value: 1.95e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2035253171    40 PGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEAlplqrANRTGGLYSCDITARG-PCTRIEFD 100
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRAND-----AGETGAVYVYFGSSGGgNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 416-449 4.45e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 44.42  E-value: 4.45e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2035253171  416 FGIAVkNIGDINQDGYPDIAVGAPYDDL---GKVFIY 449
Cdd:pfam01839    1 FGYSV-AVGDLNGDGYADLAVGAPGEGGagaGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 293-345 3.75e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 39.67  E-value: 3.75e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2035253171   293 MNSYLGFSLDSGkGIVSKDEIT-FVSGAPRANHS---GAVVLLKRDMKSAHLLPEHI 345
Cdd:smart00191    1 PGSYFGYSVAGV-GDVNGDGYPdLLVGAPRANDAgetGAVYVYFGSSGGGNSIPLQN 56
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 470-493 2.85e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.85e-03
                            10        20
                    ....*....|....*....|....
gi 2035253171   470 YFGYSIAGNMDLDRNSYPDVAVGS 493
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGA 27
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 504-978 2.05e-173

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 516.87  E-value: 2.05e-173
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  504 RPVINIQKTITVTPNRIDLRQKTaCGAPSG--ICLQVKSCFEYTANPAgYNPSISIVGTLEAEKERRKsGLSSRVQFrNQ 581
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKN-CTLTGTpvSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKKK-GLPPRVLF-LD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  582 GSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPssRRRVNSLPEVLPILNSDEPKTAHIDVHFL 661
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVD--PRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  662 KEgCGDDNVCNSNLKLEYKFCTREGNqdkfsylpiqkgvPELVLKDQKDIALEITVTNspsnprnptkDGDDAHEAKLIA 741
Cdd:pfam08441  155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTN----------LGEDAYEAELYV 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  742 TFPDTLTYSAYRelRAFPEKQLSCVANQNGS--QADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQD 819
Cdd:pfam08441  211 TLPPGLDYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQN 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  820 -NLAPITAKAKVVIELLLSVSGVAKPSQVyFGGTVVGEQAMK--SEDEVGSLIEYEFRVINLGKPltNLGTATLNIQWPK 896
Cdd:pfam08441  289 sNSNPVSLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPY 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2035253171  897 EISNGKWLLYLVKVEskGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQT----LNCSVNVN 972
Cdd:pfam08441  366 ELSNGKWLLYLLDVQ--GQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTasvlLSCDSGAR 443


                   ....*.
gi 2035253171  973 CVNIRC 978
Cdd:pfam08441  444 CVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 413-464 7.11e-15

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 69.71  E-value: 7.11e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2035253171   413 DSMFGIAVKNIGDINQDGYPDIAVGAPYDD----LGKVFIYHGSANGINTKPTQVL 464
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 353-406 5.65e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 5.65e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2035253171   353 SSFGYDVA-VVDLNKDGWQDIVIGAPQYFdrDGEVGGAVYVYMNQQ--GRWNNVKPI 406
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFGSSggGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 355-393 8.30e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.82  E-value: 8.30e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2035253171  355 FGYDVAVVDLNKDGWQDIVIGAPQYFDRDgevGGAVYVY 393
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 363-436 5.54e-08

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 50.30  E-value: 5.54e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2035253171  363 DLNKDGWQDIVIGAPqyfdrdgevgGAVYVY-MNQQGRWNNVKPIRLNGTKDSMfGIAVkniGDINQDGYPDIAV 436
Cdd:pfam13517    1 DLDGDGKLDLVVAND----------GGLRLYlNNGDGTFTFITSVSLGGGGGGL-SVAV---GDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 40-100 1.95e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.91  E-value: 1.95e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2035253171    40 PGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEAlplqrANRTGGLYSCDITARG-PCTRIEFD 100
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRAND-----AGETGAVYVYFGSSGGgNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 416-449 4.45e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 44.42  E-value: 4.45e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2035253171  416 FGIAVkNIGDINQDGYPDIAVGAPYDDL---GKVFIY 449
Cdd:pfam01839    1 FGYSV-AVGDLNGDGYADLAVGAPGEGGagaGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 425-491 2.92e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 42.60  E-value: 2.92e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2035253171  425 DINQDGYPDIAVGAPyddlGKVFIYHGSANGINTKPTQVL-----KGISPYFGysiagnmDLDRNSYPDVAV 491
Cdd:pfam13517    1 DLDGDGKLDLVVAND----GGLRLYLNNGDGTFTFITSVSlggggGGLSVAVG-------DLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 293-345 3.75e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 39.67  E-value: 3.75e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2035253171   293 MNSYLGFSLDSGkGIVSKDEIT-FVSGAPRANHS---GAVVLLKRDMKSAHLLPEHI 345
Cdd:smart00191    1 PGSYFGYSVAGV-GDVNGDGYPdLLVGAPRANDAgetGAVYVYFGSSGGGNSIPLQN 56
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 470-493 2.85e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.97  E-value: 2.85e-03
                            10        20
                    ....*....|....*....|....
gi 2035253171   470 YFGYSIAGNMDLDRNSYPDVAVGS 493
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGA 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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