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Conserved domains on  [gi|2017363573|ref|NP_001380869|]
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leucine-rich repeat-containing protein 2 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-352 6.78e-38

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.84  E-value: 6.78e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 105 LSGTQWKELPDSLKEQTHLKEWHIHNTLIQIIPTYIELFHSMKILDLPKNQITCLPPEIGRLKNLKELNVSFNHLKSIPP 184
Cdd:COG4886   120 LSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 185 ELGDCENLERLDCSGNlDLMELPFELSNLKQVTFVDISANKFSSVPiCVLRMCRLQWLDISSNDLTDLPqDIDRLEELQG 264
Cdd:COG4886   200 PLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 265 FLLYKNKLTYlpqamLNLKKLTLLVVSGDDLVELPTALCDASTPLKFVSLLDNPIDKTRCQDTDDTVESEQDRQHFDKEF 344
Cdd:COG4886   277 LDLSNNQLTD-----LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351


                  ....*...
gi 2017363573 345 MKAYIEDL 352
Cdd:COG4886   352 LLLLLNLL 359
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-352 6.78e-38

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.84  E-value: 6.78e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 105 LSGTQWKELPDSLKEQTHLKEWHIHNTLIQIIPTYIELFHSMKILDLPKNQITCLPPEIGRLKNLKELNVSFNHLKSIPP 184
Cdd:COG4886   120 LSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 185 ELGDCENLERLDCSGNlDLMELPFELSNLKQVTFVDISANKFSSVPiCVLRMCRLQWLDISSNDLTDLPqDIDRLEELQG 264
Cdd:COG4886   200 PLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 265 FLLYKNKLTYlpqamLNLKKLTLLVVSGDDLVELPTALCDASTPLKFVSLLDNPIDKTRCQDTDDTVESEQDRQHFDKEF 344
Cdd:COG4886   277 LDLSNNQLTD-----LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351


                  ....*...
gi 2017363573 345 MKAYIEDL 352
Cdd:COG4886   352 LLLLLNLL 359
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 130-320 6.13e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.51  E-value: 6.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 130 NTLIQIIPTYIELFHSMKILDLPKNQITC-LPPEIGRLKNLKELNVSFNHLK-SIPPELGDCENLERLDCSGNLDLMELP 207
Cdd:PLN00113  174 NVLVGKIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGPIP 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 208 FELSNLKQVTFVDISANKFS-SVPICVLRMCRLQWLDISSNDLT-DLPQDIDRLEELQGFLLYKNKLT-YLPQAMLNLKK 284
Cdd:PLN00113  254 SSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPR 333

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017363573 285 L------------------------TLLVVSGDDLV-ELPTALCDASTPLKFVsLLDNPID 320
Cdd:PLN00113  334 LqvlqlwsnkfsgeipknlgkhnnlTVLDLSTNNLTgEIPEGLCSSGNLFKLI-LFSNSLE 393
LRR_8 pfam13855
Leucine rich repeat;
145-201 1.38e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 1.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2017363573 145 SMKILDLPKNQITCLPPEI-GRLKNLKELNVSFNHLKSIPPE-LGDCENLERLDCSGNL 201
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 117-200 1.61e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 117 LKEQTHLKEWHIHNtliQIIP----------TYIELFHSMKILDLPKNQITCLPPeIGRLKNLKELNVSFNHLKSIP--- 183
Cdd:cd21340    86 LENLTNLEELHIEN---QRLPpgekltfdprSLAALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEell 161

                          90
                  ....*....|....*..
gi 2017363573 184 PELGDCENLERLDCSGN 200
Cdd:cd21340   162 DLLSSWPSLRELDLTGN 178
LRR smart00370
Leucine-rich repeats, outliers;
166-189 5.65e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 5.65e-03
                           10        20
                   ....*....|....*....|....
gi 2017363573  166 LKNLKELNVSFNHLKSIPPELGDC 189
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
105-352 6.78e-38

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 140.84  E-value: 6.78e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 105 LSGTQWKELPDSLKEQTHLKEWHIHNTLIQIIPTYIELFHSMKILDLPKNQITCLPPEIGRLKNLKELNVSFNHLKSIPP 184
Cdd:COG4886   120 LSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 185 ELGDCENLERLDCSGNlDLMELPFELSNLKQVTFVDISANKFSSVPiCVLRMCRLQWLDISSNDLTDLPqDIDRLEELQG 264
Cdd:COG4886   200 PLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 265 FLLYKNKLTYlpqamLNLKKLTLLVVSGDDLVELPTALCDASTPLKFVSLLDNPIDKTRCQDTDDTVESEQDRQHFDKEF 344
Cdd:COG4886   277 LDLSNNQLTD-----LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351


                  ....*...
gi 2017363573 345 MKAYIEDL 352
Cdd:COG4886   352 LLLLLNLL 359
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
114-319 6.20e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.14  E-value: 6.20e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 114 PDSLKEQTHLKEWHIHNTLIQIIPTYIELFHSMKILDLPKNQITCLPPEIGRLKNLKELNVSFNHLKSIPPELGDCENLE 193
Cdd:COG4886   106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLK 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 194 RLDCSGNlDLMELPFELSNLKQVTFVDISANKFSSVPICVLRMCRLQWLDISSNDLTDLPqDIDRLEELQGFLLYKNKLT 273
Cdd:COG4886   186 ELDLSNN-QITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2017363573 274 YLPQAmLNLKKLTLLVVSGDDLVELPTALCDASTPLKFVSLLDNPI 319
Cdd:COG4886   264 DLPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-320 2.53e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 2.53e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 104 ELSGTQWKELPDSLKEQTHLKEWHIHNTLIQIIPTYIELFHSMKILDLPKNQITCLPPEIGRLKNLKELNVSFNHLKSIp 183
Cdd:COG4886   165 DLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL- 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 184 PELGDCENLERLDCSGNlDLMELPfELSNLKQVTFVDISANKFSSVPICVLrmcrlqWLDISSNDLTDLPQDIDRLEELQ 263
Cdd:COG4886   244 PELGNLTNLEELDLSNN-QLTDLP-PLANLTNLKTLDLSNNQLTDLKLKEL------ELLLGLNSLLLLLLLLNLLELLI 315

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2017363573 264 GFLLYKNKLTYLPQAMLNLKKLTLLVVSGDDLVELPTALCDASTPLKFVSLLDNPID 320
Cdd:COG4886   316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
130-319 1.06e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 1.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 130 NTLIQIIPTYIELFHSMKILDLPKNQITCLPPEIGRLKNLKELNVSFNHLKSIPPELGDCENLERLDCSGNLdlmelpfE 209
Cdd:COG4886    36 ALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------E 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 210 LSNLKQVTFVDISANKFSSVPICVLRMCRLQWLDISSNDLTDLPQDIDRLEELQGFLLYKNKLTYLPQAMLNLKKLTLLV 289
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELD 188

                         170       180       190
                  ....*....|....*....|....*....|
gi 2017363573 290 VSGDDLVELPTALCDASTpLKFVSLLDNPI 319
Cdd:COG4886   189 LSNNQITDLPEPLGNLTN-LEELDLSGNQL 217
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 130-320 6.13e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.51  E-value: 6.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 130 NTLIQIIPTYIELFHSMKILDLPKNQITC-LPPEIGRLKNLKELNVSFNHLK-SIPPELGDCENLERLDCSGNLDLMELP 207
Cdd:PLN00113  174 NVLVGKIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGPIP 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 208 FELSNLKQVTFVDISANKFS-SVPICVLRMCRLQWLDISSNDLT-DLPQDIDRLEELQGFLLYKNKLT-YLPQAMLNLKK 284
Cdd:PLN00113  254 SSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPR 333

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2017363573 285 L------------------------TLLVVSGDDLV-ELPTALCDASTPLKFVsLLDNPID 320
Cdd:PLN00113  334 LqvlqlwsnkfsgeipknlgkhnnlTVLDLSTNNLTgEIPEGLCSSGNLFKLI-LFSNSLE 393
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
136-319 3.87e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.80  E-value: 3.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 136 IPTYIELFHSMKILDlpKNQITCLPPEIGrlKNLKELNVSFNHLKSIPPELGDceNLERLDCSGNlDLMELPFELSNLKQ 215
Cdd:PRK15370  193 IPACIPEQITTLILD--NNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPD--TIQEMELSIN-RITELPERLPSALQ 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 216 VtfVDISANKFSSVPICVLRmcRLQWLDISSNDLTDLPQDIDrlEELQGFLLYKNKLTYLPQAM-LNLKKLtllvVSGDD 294
Cdd:PRK15370  266 S--LDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLpPGLKTL----EAGEN 335

                         170       180
                  ....*....|....*....|....*.
gi 2017363573 295 -LVELPTALCDAstpLKFVSLLDNPI 319
Cdd:PRK15370  336 aLTSLPASLPPE---LQVLDVSKNQI 358
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 105-314 8.90e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.80  E-value: 8.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 105 LSGtqwkELPDSLKEQTHLKEWHI-HNTLIQIIPTYIELFHSMKILDLPKNQITC-LPPEIGRLKNLKELNVSFNHLK-- 180
Cdd:PLN00113  296 LSG----EIPELVIQLQNLEILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNNLTge 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 181 -----------------------SIPPELGDCENLERLDCSGNLDLMELPFELSNLKQVTFVDISANKFS-SVPICVLRM 236
Cdd:PLN00113  372 ipeglcssgnlfklilfsnslegEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDM 451

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 237 CRLQWLDISSNDLT-DLPQDI--DRLEELQgflLYKNKLT-YLPQAMLNLKKLTLLVVSGDDLV-ELPTALcdaSTPLKF 311
Cdd:PLN00113  452 PSLQMLSLARNKFFgGLPDSFgsKRLENLD---LSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDEL---SSCKKL 525


                  ...
gi 2017363573 312 VSL 314
Cdd:PLN00113  526 VSL 528
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 130-299 4.92e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.48  E-value: 4.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 130 NTLIQIIPTYI-ELFHSMKILDLPKNQITCLPPEiGRLKNLKELNVSFNHLK-SIPPELGDCENLERLDCSGNLDLMELP 207
Cdd:PLN00113  103 NQLSGPIPDDIfTTSSSLRYLNLSNNNFTGSIPR-GSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIP 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 208 FELSNLKQVTFVDISANKFS-SVPICVLRMCRLQW------------------------LDISSNDLT-DLPQDIDRLEE 261
Cdd:PLN00113  182 NSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWiylgynnlsgeipyeiggltslnhLDLVYNNLTgPIPSSLGNLKN 261

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2017363573 262 LQGFLLYKNKLT-YLPQAMLNLKKLTLLVVSGDDLV-ELP 299
Cdd:PLN00113  262 LQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIP 301
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
154-297 8.19e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 54.01  E-value: 8.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 154 NQITCLPPeigRLKNLKELNVSFNHLKSIPPELGDCENLerldCSGNLDLMELPFELSNLKQVTfvdISANKFSSVPICV 233
Cdd:PRK15387  332 NQLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKL----WAYNNRLTSLPALPSGLKELI---VSGNRLTSLPVLP 401

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2017363573 234 lrmCRLQWLDISSNDLTDLPQDIDRLEELQgflLYKNKLTYLPQAMLNLKKLTLLVVSGDDLVE 297
Cdd:PRK15387  402 ---SELKELMVSGNRLTSLPMLPSGLLSLS---VYRNQLTRLPESLIHLSSETTVNLEGNPLSE 459
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
102-279 6.44e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 6.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 102 VFELSGTQWKELPDSLKeqTHLKEWHIHNTLIQIIPTyiELFHSMKILDLPKNQITCLPPEIGrlKNLKELNVSFNHLKS 181
Cdd:PRK15370  245 EMELSINRITELPERLP--SALQSLDLFHNKISCLPE--NLPEELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTA 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 182 IPPELGdcENLERLDCSGNLdLMELPFELSNLKQVtfVDISANKFSSVPICVLRMcrLQWLDISSNDLTDLPQDIDrlEE 261
Cdd:PRK15370  319 LPETLP--PGLKTLEAGENA-LTSLPASLPPELQV--LDVSKNQITVLPETLPPT--ITTLDVSRNALTNLPENLP--AA 389

                         170
                  ....*....|....*...
gi 2017363573 262 LQGFLLYKNKLTYLPQAM 279
Cdd:PRK15370  390 LQIMQASRNNLVRLPESL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 146-249 1.06e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 146 MKILDLPKNQIT-CLPPEIGRLKNLKELNVSFNHLKS-IPPELGDCENLERLDCSGNLDLMELPFELSNLKQVTFVDISA 223
Cdd:PLN00113  477 LENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQ 556

                          90       100
                  ....*....|....*....|....*..
gi 2017363573 224 NKFS-SVPICVLRMCRLQWLDISSNDL 249
Cdd:PLN00113  557 NQLSgEIPKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 105-272 3.77e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 3.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 105 LSGtqwkELPDSLKEQTHLKEWH-IHNTLIQIIPTYIELFHSMKILDLPKNQIT-CLPPEIGRLKNLKELNVSFNHLKSI 182
Cdd:PLN00113  224 LSG----EIPYEIGGLTSLNHLDlVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGE 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 183 PPEL-GDCENLERLDCSGNLDLMELPFELSNLKQVTFVDISANKFS-SVPICVLRMCRLQWLDISSNDLT-DLPQDIDRL 259
Cdd:PLN00113  300 IPELvIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSS 379

                         170
                  ....*....|...
gi 2017363573 260 EELQGFLLYKNKL 272
Cdd:PLN00113  380 GNLFKLILFSNSL 392
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
131-299 5.32e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 48.23  E-value: 5.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 131 TLIQIIPTYIelfhsmKILDLPKNQIT---CLPPEigrlknLKELNVSFNHLKSIPP------ELGDCEN---------- 191
Cdd:PRK15387  215 TLPDCLPAHI------TTLVIPDNNLTslpALPPE------LRTLEVSGNQLTSLPVlppgllELSIFSNplthlpalps 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 192 -LERLDCSGNlDLMELPFELSNLKQVTfvdISANKFSSVPICVLRMCR-----------------LQWLDISSNDLTDLP 253
Cdd:PRK15387  283 gLCKLWIFGN-QLTSLPVLPPGLQELS---VSDNQLASLPALPSELCKlwaynnqltslptlpsgLQELSVSDNQLASLP 358

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2017363573 254 QdidRLEELQGFLLYKNKLTYLPQAMLNLKKltlLVVSGDDLVELP 299
Cdd:PRK15387  359 T---LPSELYKLWAYNNRLTSLPALPSGLKE---LIVSGNRLTSLP 398
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 112-230 1.35e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 112 ELPDSLKEQtHLKEWHI-HNTLIQIIPTYIELFHSMKILDLPKNQIT-CLPPEIGRLKNLKELNVSFNHLK-SIPPELGD 188
Cdd:PLN00113  467 GLPDSFGSK-RLENLDLsRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSE 545

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2017363573 189 CENLERLDCSGNLDLMELPFELSNLKQVTFVDISANKF-SSVP 230
Cdd:PLN00113  546 MPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLhGSLP 588
LRR_8 pfam13855
Leucine rich repeat;
145-201 1.38e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 1.38e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2017363573 145 SMKILDLPKNQITCLPPEI-GRLKNLKELNVSFNHLKSIPPE-LGDCENLERLDCSGNL 201
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
238-295 4.57e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 4.57e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 238 RLQWLDISSNDLTDLPQDI-DRLEELQGFLLYKNKLTYL-PQAMLNLKKLTLLVVSGDDL 295
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 167-208 6.56e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 6.56e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2017363573 167 KNLKELNVSFNHLKSIPPeLGDCENLERLDCSGNLDLMELPF 208
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNNKITDLSD 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 117-200 1.61e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 117 LKEQTHLKEWHIHNtliQIIP----------TYIELFHSMKILDLPKNQITCLPPeIGRLKNLKELNVSFNHLKSIP--- 183
Cdd:cd21340    86 LENLTNLEELHIEN---QRLPpgekltfdprSLAALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEell 161

                          90
                  ....*....|....*..
gi 2017363573 184 PELGDCENLERLDCSGN 200
Cdd:cd21340   162 DLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 117-287 2.04e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 2.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 117 LKEQTHLkewHIHNTLIQIIPTyIELFHSMKILDLPKNQITCLPPeIGRLKNLKELNVSFNHLKSIPPeLGDCENLERLD 196
Cdd:cd21340     1 LKRITHL---YLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 197 CSGN-------LD----LMEL----------------PFELSNL-KQVTFVDISANKFSSV-PICVLRmcRLQWLDISSN 247
Cdd:cd21340    75 LGGNrisvvegLEnltnLEELhienqrlppgekltfdPRSLAALsNSLRVLNISGNNIDSLePLAPLR--NLEQLDASNN 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2017363573 248 DLTDlpqdidrLEELQGFLlyknkltylpQAMLNLKKLTL 287
Cdd:cd21340   153 QISD-------LEELLDLL----------SSWPSLRELDL 175
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 104-246 4.06e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2017363573 104 ELSGtqwkELPDSLKEQTHLKEWHI-HNTLIQIIPTYIELFHSMKILDLPKNQITC-LPPEIGRLKNLKELNVSFNHLKS 181
Cdd:PLN00113  510 KLSG----EIPDELSSCKKLVSLDLsHNQLSGQIPASFSEMPVLSQLDLSQNQLSGeIPKNLGNVESLVQVNISHNHLHG 585

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2017363573 182 IPPELGDCENLERLDCSGNLDLmelpfelsnlkqvtfvdISANKFSSVPIC-VLRMCRLQWLDISS 246
Cdd:PLN00113  586 SLPSTGAFLAINASAVAGNIDL-----------------CGGDTTSGLPPCkRVRKTPSWWFYITC 634
LRR_8 pfam13855
Leucine rich repeat;
121-179 1.15e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2017363573 121 THLKEWHIHNTLIQIIPTyiELFHSM---KILDLPKNQITCLPPE-IGRLKNLKELNVSFNHL 179
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD--GAFKGLsnlKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR smart00370
Leucine-rich repeats, outliers;
166-189 5.65e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 5.65e-03
                           10        20
                   ....*....|....*....|....
gi 2017363573  166 LKNLKELNVSFNHLKSIPPELGDC 189
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
166-189 5.65e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 33.86  E-value: 5.65e-03
                           10        20
                   ....*....|....*....|....
gi 2017363573  166 LKNLKELNVSFNHLKSIPPELGDC 189
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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