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Conserved domains on  [gi|1973548082|ref|NP_001380269|]
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lipid transferase CIDEB isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CIDE_N super family cl02541
CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) ...
 34-67 5.15e-16

CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of ICAD/DFF45, and the CAD/DFF40 and CIDE nucleases during apoptosis. The CIDE-N domain is also found in the FSP27/CIDE-C protein.


The actual alignment was detected with superfamily member cd06537:

Pssm-ID: 470607  Cd Length: 81  Bit Score: 68.79  E-value: 5.15e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1973548082  34 PQRPFRVCDHKRTIRKGLTAATRQELLAK-------SGVLS 67
Cdd:cd06537     1 PQRPFRVCDHKRTVRKGLTAASLQELLAKaletlllSGVLT 41
 
Name Accession Description Interval E-value
CIDE_N_B cd06537
CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, ...
 34-67 5.15e-16

CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40, ICAD/DFF45 and CIDE nucleases during apoptosis. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, CIDE proteins were initially characterized as mitochondrial activators of apoptosis. However, strong metabolic phenotypes of mice lacking CIDE-A and CIDE-B indicated that this family may play critical roles in energy balance.


Pssm-ID: 119370  Cd Length: 81  Bit Score: 68.79  E-value: 5.15e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1973548082  34 PQRPFRVCDHKRTIRKGLTAATRQELLAK-------SGVLS 67
Cdd:cd06537     1 PQRPFRVCDHKRTVRKGLTAASLQELLAKaletlllSGVLT 41
CAD smart00266
Domains present in proteins implicated in post-mortem DNA fragmentation;
36-62 1.88e-08

Domains present in proteins implicated in post-mortem DNA fragmentation;


Pssm-ID: 128562  Cd Length: 74  Bit Score: 48.86  E-value: 1.88e-08
                           10        20
                   ....*....|....*....|....*..
gi 1973548082   36 RPFRVCDHKRTIRKGLTAATRQELLAK 62
Cdd:smart00266   1 RPFKVRDHDRNVRKGVAASSLEELLSK 27
CIDE-N pfam02017
CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. ...
 36-62 3.74e-06

CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.


Pssm-ID: 460413  Cd Length: 75  Bit Score: 42.87  E-value: 3.74e-06
                          10        20
                  ....*....|....*....|....*..
gi 1973548082  36 RPFRVCDHKRTIRKGLTAATRQELLAK 62
Cdd:pfam02017   1 KPFKVCNVDRSRKKGVAASSLEELLQK 27
 
Name Accession Description Interval E-value
CIDE_N_B cd06537
CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, ...
 34-67 5.15e-16

CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40, ICAD/DFF45 and CIDE nucleases during apoptosis. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, CIDE proteins were initially characterized as mitochondrial activators of apoptosis. However, strong metabolic phenotypes of mice lacking CIDE-A and CIDE-B indicated that this family may play critical roles in energy balance.


Pssm-ID: 119370  Cd Length: 81  Bit Score: 68.79  E-value: 5.15e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1973548082  34 PQRPFRVCDHKRTIRKGLTAATRQELLAK-------SGVLS 67
Cdd:cd06537     1 PQRPFRVCDHKRTVRKGLTAASLQELLAKaletlllSGVLT 41
CIDE_N cd01615
CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) ...
 34-62 1.62e-09

CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of ICAD/DFF45, and the CAD/DFF40 and CIDE nucleases during apoptosis. The CIDE-N domain is also found in the FSP27/CIDE-C protein.


Pssm-ID: 119367  Cd Length: 78  Bit Score: 51.77  E-value: 1.62e-09
                          10        20
                  ....*....|....*....|....*....
gi 1973548082  34 PQRPFRVCDHKRTIRKGLTAATRQELLAK 62
Cdd:cd01615     1 PLRPFKVCDSDRSRKKGVAASSLEELLSK 29
CAD smart00266
Domains present in proteins implicated in post-mortem DNA fragmentation;
36-62 1.88e-08

Domains present in proteins implicated in post-mortem DNA fragmentation;


Pssm-ID: 128562  Cd Length: 74  Bit Score: 48.86  E-value: 1.88e-08
                           10        20
                   ....*....|....*....|....*..
gi 1973548082   36 RPFRVCDHKRTIRKGLTAATRQELLAK 62
Cdd:smart00266   1 RPFKVRDHDRNVRKGVAASSLEELLSK 27
CIDE_N_A cd06539
CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, ...
 34-63 6.02e-07

CIDE_N domain of CIDE-A proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin condensation and DNA fragmentation events of apoptosis; the CIDE_N domain is thought to regulate the activity of the CAD/DFF40, ICAD/DFF45, and CIDE nucleases during apoptosis. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, the CIDE proteins were initially characterized as mitochondrial activators of apoptosis. However, strong metabolic phenotypes of mice lacking CIDE-A and CIDE-B indicated that this family may play critical roles in energy balance.


Pssm-ID: 119372  Cd Length: 78  Bit Score: 44.93  E-value: 6.02e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1973548082  34 PQRPFRVCDHKRTIRKGLTAATRQELLAKS 63
Cdd:cd06539     1 PARPFRVSNHDRSSRRGVMASSLQELISKT 30
CIDE-N pfam02017
CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. ...
 36-62 3.74e-06

CIDE-N domain; This domain is found in CAD nuclease, and ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.


Pssm-ID: 460413  Cd Length: 75  Bit Score: 42.87  E-value: 3.74e-06
                          10        20
                  ....*....|....*....|....*..
gi 1973548082  36 RPFRVCDHKRTIRKGLTAATRQELLAK 62
Cdd:pfam02017   1 KPFKVCNVDRSRKKGVAASSLEELLQK 27
CIDE_N_FSP27 cd06538
CIDE_N domain of FSP27 proteins. The CIDE-N (cell death-inducing DFF45-like effector, ...
 36-64 2.09e-03

CIDE_N domain of FSP27 proteins. The CIDE-N (cell death-inducing DFF45-like effector, N-terminal) domain is found in the FSP27/CIDE-C protein, which has been identified as a n adipocyte lipid droplet protein that negatively regulates lipolysis and promotes triglyceride accumulation. The CIDE protein family includes 3 members: CIDE-A, CIDE-B, and FSP27(CIDE-C). Based on sequence similarity with DFF40 and DFF45, CIDE proteins were initially characterized as mitochondrial activators of apoptosis. The CIDE-N domain of FSP27 is sufficient to increase apoptosis in vitro when overexpressed.


Pssm-ID: 119371  Cd Length: 79  Bit Score: 35.56  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|....*....
gi 1973548082  36 RPFRVCDHKRTIRKGLTAATRQELLAKSG 64
Cdd:cd06538     3 RPFRVSNADRSLRKGIMADSLEDLLNKVL 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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