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Conserved domains on  [gi|1972309255|ref|NP_001380230|]
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GTP 3',8-cyclase [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoaC super family cl00242
MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, ...
 1-39 2.61e-21

MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


The actual alignment was detected with superfamily member cd01420:

Pssm-ID: 469682  Cd Length: 140  Bit Score: 79.51  E-value: 2.61e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGK 39
Cdd:cd01420    99 MEALTAVSVAALTIYDMCKAVDKGMVIGGIRLLEKSGGK 137
 
Name Accession Description Interval E-value
MoaC_PE cd01420
MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum ...
 1-39 2.61e-21

MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


Pssm-ID: 238708  Cd Length: 140  Bit Score: 79.51  E-value: 2.61e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGK 39
Cdd:cd01420    99 MEALTAVSVAALTIYDMCKAVDKGMVIGGIRLLEKSGGK 137
MoaC pfam01967
MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However ...
 1-38 9.84e-20

MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However their molecular function is not known.


Pssm-ID: 460399  Cd Length: 136  Bit Score: 75.07  E-value: 9.84e-20
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGG 38
Cdd:pfam01967  99 MEALTAVSVAALTIYDMCKAVDKGMVIGDIRLLEKSGG 136
MoaC COG0315
Molybdenum cofactor biosynthesis enzyme MoaC [Coenzyme transport and metabolism]; Molybdenum ...
 1-39 1.01e-19

Molybdenum cofactor biosynthesis enzyme MoaC [Coenzyme transport and metabolism]; Molybdenum cofactor biosynthesis enzyme MoaC is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440084  Cd Length: 153  Bit Score: 75.48  E-value: 1.01e-19
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGK 39
Cdd:COG0315   113 MEALTAVSVAALTIYDMCKAVDKGMVIEDIRLLEKSGGK 151
moaC PRK09364
cyclic pyranopterin monophosphate synthase MoaC;
1-40 4.71e-19

cyclic pyranopterin monophosphate synthase MoaC;


Pssm-ID: 236483  Cd Length: 159  Bit Score: 74.07  E-value: 4.71e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGKT 40
Cdd:PRK09364  113 MEALTAVSVAALTIYDMCKAVDKGMVIGDVRLLEKSGGKS 152
moaC TIGR00581
molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum ...
 1-39 1.17e-14

molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum cofactor biosynthesis in E. coli. The Arabidopsis homolog Cnx3 complements MoaC deficiency in E. coli. Eukarotic members of this family branch within the bacterial branch, with the archaeal members as an apparent outgroup. This protein is absent in a number of the pathogens with smaller genomes, including Mycoplasmas, Chlamydias, and spirochetes, but is found in most other complete genomes to date. The homolog form Synechocystis sp. is fused to a MobA-homologous region and is an outlier to all other bacterial forms by both neighbor-joining and UPGMA analyses. Members of this family are well-conserved. The seed for this model excludes both archaeal sequences and the most divergent bacterial sequences, but still finds all candidate MoaC sequences easily between trusted and noise cutoffs. We suggest that sequences branching outside the set that contains all seed members be regarded only as putative functional equivalents of MoaC unless and until a member of the archaeal outgroup is shown to have equivalent function. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 129670  Cd Length: 147  Bit Score: 62.45  E-value: 1.17e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGK 39
Cdd:TIGR00581 108 MEALTAVSVAALTVYDMCKAVDKDMVIGPVRLLEKSGGK 146
 
Name Accession Description Interval E-value
MoaC_PE cd01420
MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum ...
 1-39 2.61e-21

MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


Pssm-ID: 238708  Cd Length: 140  Bit Score: 79.51  E-value: 2.61e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGK 39
Cdd:cd01420    99 MEALTAVSVAALTIYDMCKAVDKGMVIGGIRLLEKSGGK 137
MoaC pfam01967
MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However ...
 1-38 9.84e-20

MoaC family; Members of this family are involved in molybdenum cofactor biosynthesis. However their molecular function is not known.


Pssm-ID: 460399  Cd Length: 136  Bit Score: 75.07  E-value: 9.84e-20
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGG 38
Cdd:pfam01967  99 MEALTAVSVAALTIYDMCKAVDKGMVIGDIRLLEKSGG 136
MoaC COG0315
Molybdenum cofactor biosynthesis enzyme MoaC [Coenzyme transport and metabolism]; Molybdenum ...
 1-39 1.01e-19

Molybdenum cofactor biosynthesis enzyme MoaC [Coenzyme transport and metabolism]; Molybdenum cofactor biosynthesis enzyme MoaC is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440084  Cd Length: 153  Bit Score: 75.48  E-value: 1.01e-19
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGK 39
Cdd:COG0315   113 MEALTAVSVAALTIYDMCKAVDKGMVIEDIRLLEKSGGK 151
moaC PRK09364
cyclic pyranopterin monophosphate synthase MoaC;
1-40 4.71e-19

cyclic pyranopterin monophosphate synthase MoaC;


Pssm-ID: 236483  Cd Length: 159  Bit Score: 74.07  E-value: 4.71e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGKT 40
Cdd:PRK09364  113 MEALTAVSVAALTIYDMCKAVDKGMVIGDVRLLEKSGGKS 152
MoaC cd00528
MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, ...
 1-38 4.97e-19

MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor Z by inserting the carbon-8 of the purine between the 2' and 3' ribose carbon atoms, which is the first of three phases of Moco biosynthesis.


Pssm-ID: 238293  Cd Length: 136  Bit Score: 73.32  E-value: 4.97e-19
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGG 38
Cdd:cd00528    99 MEALTAVSVAALTIYDMCKAVDKDMVIENIRLLEKSGG 136
moaC TIGR00581
molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum ...
 1-39 1.17e-14

molybdenum cofactor biosynthesis protein MoaC; MoaC catalyzes an early step in molybdenum cofactor biosynthesis in E. coli. The Arabidopsis homolog Cnx3 complements MoaC deficiency in E. coli. Eukarotic members of this family branch within the bacterial branch, with the archaeal members as an apparent outgroup. This protein is absent in a number of the pathogens with smaller genomes, including Mycoplasmas, Chlamydias, and spirochetes, but is found in most other complete genomes to date. The homolog form Synechocystis sp. is fused to a MobA-homologous region and is an outlier to all other bacterial forms by both neighbor-joining and UPGMA analyses. Members of this family are well-conserved. The seed for this model excludes both archaeal sequences and the most divergent bacterial sequences, but still finds all candidate MoaC sequences easily between trusted and noise cutoffs. We suggest that sequences branching outside the set that contains all seed members be regarded only as putative functional equivalents of MoaC unless and until a member of the archaeal outgroup is shown to have equivalent function. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 129670  Cd Length: 147  Bit Score: 62.45  E-value: 1.17e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGK 39
Cdd:TIGR00581 108 MEALTAVSVAALTVYDMCKAVDKDMVIGPVRLLEKSGGK 146
PRK14499 PRK14499
cyclic pyranopterin monophosphate synthase MoaC/MOSC-domain-containing protein;
1-49 1.63e-14

cyclic pyranopterin monophosphate synthase MoaC/MOSC-domain-containing protein;


Pssm-ID: 237733 [Multi-domain]  Cd Length: 308  Bit Score: 64.50  E-value: 1.63e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGKT-TYTIDNENQ 49
Cdd:PRK14499  112 MEAITAVSIFLETIYDMCKAVKKDMVITDVRLIEKSGGKSgHYIFERRNK 161
moaC PRK03604
bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional
 1-40 2.88e-14

bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional


Pssm-ID: 235138 [Multi-domain]  Cd Length: 312  Bit Score: 63.81  E-value: 2.88e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGKT 40
Cdd:PRK03604  107 MEALTAVSVAALTIYDMLKPVDKALEIGGIRLLEKTGGKS 146
PLN02375 PLN02375
molybderin biosynthesis protein CNX3
 1-42 3.95e-10

molybderin biosynthesis protein CNX3


Pssm-ID: 178003 [Multi-domain]  Cd Length: 270  Bit Score: 52.46  E-value: 3.95e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGKTTY 42
Cdd:PLN02375  225 MEAMTAVSVAGLTVYDMCKAASKDISITDVRLERKTGGKSGS 266
PRK14500 PRK14500
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MoaC/MobA; ...
 1-41 6.90e-10

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MoaC/MobA; Provisional


Pssm-ID: 237734 [Multi-domain]  Cd Length: 346  Bit Score: 51.82  E-value: 6.90e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1972309255   1 MEALTACTIALLTVYDMCKAISQKMMLTNIYLVHKSGGKTT 41
Cdd:PRK14500  115 MEALCGVAVAALTIYDMCKSISPHIIIKETRLIEKSGGKAD 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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