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Conserved domains on  [gi|1972243566|ref|NP_001379857|]
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FBA_2 domain-containing protein [Caenorhabditis elegans]

Protein Classification

lipocalin/fatty acid-binding family protein( domain architecture ID 3669)

lipocalin/fatty acid-binding family protein contains a large beta-barrel cavity that binds hydrophobic ligands

CATH:  2.40.128.20
Gene Ontology:  GO:0036094
PubMed:  11058745|11058743
SCOP:  3001332

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
lipocalin_FABP super family cl10502
lipocalin/cytosolic fatty acid-binding protein family; Lipocalins are diverse, mainly low ...
 38-159 1.26e-03

lipocalin/cytosolic fatty acid-binding protein family; Lipocalins are diverse, mainly low molecular weight extracellular proteins that bind principally small hydrophobic ligands, and form covalent or non-covalent complexes with soluble macromolecules as well as membrane bound-receptors. They have a large beta-barrel ligand-binding cavity. Members include retinol-binding protein, retinoic acid-binding protein, complement protein C8 gamma, Can f 2, apolipoprotein D, extracellular fatty acid-binding protein, beta-lactoglobulin, oderant-binding protein, and bacterial lipocalin Blc. Lipocalins are involved in many important processes such as ligand transport, modulation of cell growth and metabolism, regulation of immune response, smell reception, tissue development and animal behavior. Cytosolic fatty acid-binding proteins also bind hydrophobic ligands in a non-covalent, reversible manner, and are involved in protection and shuttling of fatty acids within the cell, and in acquisition and removal of fatty acids from intracellular sites.


The actual alignment was detected with superfamily member cd19471:

Pssm-ID: 471979  Cd Length: 130  Bit Score: 36.87  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972243566  38 EQIVGTWKLASSENCPNFIEWFGIEKKKSNYGYYNDLTQAKLNENLVFKMNYNNIVGIPKLFPHMSE---KTVRENRHIK 114
Cdd:cd19471     2 EPFLGTWKLVSSENFENYVKELGVEFAARNVAGLIKPTVTISFNGEMMTIQTGSACRNTKISFKLGEefdETTADNRKVK 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1972243566 115 T--TDDRSLKLTIDRYidMGKlNVTMELKVNEGKHVCTCKL---VYDRVY 159
Cdd:cd19471    82 SliTLENGSMIHVQKW--LGK-ETTIKRKIVDGKMVVECTMnnvVSTRIY 128
 
Name Accession Description Interval E-value
FABP9 cd19471
fatty acid binding protein 9 and similar proteins; FABP9 (also known as testis-FABP, T-FABP, ...
 38-159 1.26e-03

fatty acid binding protein 9 and similar proteins; FABP9 (also known as testis-FABP, T-FABP, PERF15) is a major protein found in the inner acrosomal membrane and outer face of the nuclear envelope of mammalian sperm. Its expression is increased in prostate cancer. This subgroup belongs to the intracellular fatty-acid binding protein (FABP) family, members of which are small proteins that bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381246  Cd Length: 130  Bit Score: 36.87  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972243566  38 EQIVGTWKLASSENCPNFIEWFGIEKKKSNYGYYNDLTQAKLNENLVFKMNYNNIVGIPKLFPHMSE---KTVRENRHIK 114
Cdd:cd19471     2 EPFLGTWKLVSSENFENYVKELGVEFAARNVAGLIKPTVTISFNGEMMTIQTGSACRNTKISFKLGEefdETTADNRKVK 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1972243566 115 T--TDDRSLKLTIDRYidMGKlNVTMELKVNEGKHVCTCKL---VYDRVY 159
Cdd:cd19471    82 SliTLENGSMIHVQKW--LGK-ETTIKRKIVDGKMVVECTMnnvVSTRIY 128
 
Name Accession Description Interval E-value
FABP9 cd19471
fatty acid binding protein 9 and similar proteins; FABP9 (also known as testis-FABP, T-FABP, ...
 38-159 1.26e-03

fatty acid binding protein 9 and similar proteins; FABP9 (also known as testis-FABP, T-FABP, PERF15) is a major protein found in the inner acrosomal membrane and outer face of the nuclear envelope of mammalian sperm. Its expression is increased in prostate cancer. This subgroup belongs to the intracellular fatty-acid binding protein (FABP) family, members of which are small proteins that bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381246  Cd Length: 130  Bit Score: 36.87  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972243566  38 EQIVGTWKLASSENCPNFIEWFGIEKKKSNYGYYNDLTQAKLNENLVFKMNYNNIVGIPKLFPHMSE---KTVRENRHIK 114
Cdd:cd19471     2 EPFLGTWKLVSSENFENYVKELGVEFAARNVAGLIKPTVTISFNGEMMTIQTGSACRNTKISFKLGEefdETTADNRKVK 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1972243566 115 T--TDDRSLKLTIDRYidMGKlNVTMELKVNEGKHVCTCKL---VYDRVY 159
Cdd:cd19471    82 SliTLENGSMIHVQKW--LGK-ETTIKRKIVDGKMVVECTMnnvVSTRIY 128
FABP4 cd19467
fatty acid binding protein 4; FABP4 (also known as A-FABP, adipocyte fatty acid binding ...
 38-157 1.40e-03

fatty acid binding protein 4; FABP4 (also known as A-FABP, adipocyte fatty acid binding protein, aP2) is highly expressed in macrophages and in adipocytes where it regulates fatty acid storage and lipolysis and is an important mediator of inflammation. It binds long chain fatty acids, retinoic acid and eicosanoids. This subgroup belongs to the intracellular fatty-acid binding protein (FABP) family, members of which are small proteins that bind hydrophobic ligands in a non-covalent, reversible manner, and have been implicated in intracellular uptake, transport and storage of hydrophobic ligands, regulation of lipid metabolism and sequestration of excess toxic fatty acids, as well as in signaling, gene expression, inflammation, cell growth and proliferation, and cancer development.


Pssm-ID: 381242  Cd Length: 130  Bit Score: 36.91  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972243566  38 EQIVGTWKLASSENCPNFIEWFGIekkksnyGYYNDLTQAKLNENLVFKMNyNNIVGIpklfphMSEKTVReNRHIK--- 114
Cdd:cd19467     2 DAFVGTWKLVSSENFDDYMKEVGV-------GFATRKVAGMAKPNMIISVN-GDVITI------RSESTFK-NTEISfkl 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972243566 115 -------TTDDRSLKLTIDryIDMGKLN---------VTMELKVNEGKHV-------CTCKLVYDR 157
Cdd:cd19467    67 gvefdevTADDRKVKSIIT--LDGGALVqvqkwdgksTTIKRKRDDDKLVvecvmkgVTSTRVYER 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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