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Conserved domains on  [gi|1972289472|ref|NP_001379787|]
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Phosphatidylethanolamine-binding protein homolog F40A3.3 [Caenorhabditis elegans]

Protein Classification

YbhB/YbcL family Raf kinase inhibitor-like protein( domain architecture ID 10096268)

YbhB/YbcL family Raf kinase inhibitor-like protein similar to mammalian phosphatidylethanolamine-binding protein 1/2 and Schizosaccharomyces pombe mitochondrial 54S ribosomal protein L35

CATH:  3.90.280.10
SCOP:  4002457

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 23-170 5.91e-61

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


:

Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 186.43  E-value: 5.91e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  23 KVVSVKFNSGVEANLGNVLTPTQVKDTPEVKWDAE--PGALYTLIKTDPDAPSRKEPTYREWHHWLVVNIPGND-----I 95
Cdd:cd00866     1 VDLTVSYGSSGVVTPGNLLTPSETQKAPTVSFSSEdpPDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSDtttglV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972289472  96 AKGDTLSEYIGAGPPPKTGLHRYVYLIYKQSGRIEDAEHgRLTNTSGDKRGGWKAADFVAKHKLGAPVFGNLFQA 170
Cdd:cd00866    81 SKGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPES-KLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 23-170 5.91e-61

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 186.43  E-value: 5.91e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  23 KVVSVKFNSGVEANLGNVLTPTQVKDTPEVKWDAE--PGALYTLIKTDPDAPSRKEPTYREWHHWLVVNIPGND-----I 95
Cdd:cd00866     1 VDLTVSYGSSGVVTPGNLLTPSETQKAPTVSFSSEdpPDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSDtttglV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972289472  96 AKGDTLSEYIGAGPPPKTGLHRYVYLIYKQSGRIEDAEHgRLTNTSGDKRGGWKAADFVAKHKLGAPVFGNLFQA 170
Cdd:cd00866    81 SKGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPES-KLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
PLN00169 PLN00169
CETS family protein; Provisional
 11-163 3.70e-20

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 82.55  E-value: 3.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  11 VIPDVLasNPPSKVVSVKFNSGV-EANLGNVLTPTQVKDTPEVKWDAEP-GALYTLIKTDPDAPSRKEPTYREWHHWLVV 88
Cdd:PLN00169   14 VVGDVL--DPFTRSISLRVTYGSrEVNNGCELKPSQVVNQPRVDIGGEDlRTFYTLVMVDPDAPSPSNPNLREYLHWLVT 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972289472  89 NIPGNDIAK-GDTLSEYigAGPPPKTGLHRYVYLIYKQSgriedaehGRLTNTSGDKRGGWKAADFVAKHKLGAPV 163
Cdd:PLN00169   92 DIPATTGATfGQEVVCY--ESPRPTAGIHRFVFVLFRQL--------GRQTVYAPGWRQNFNTRDFAELYNLGSPV 157
PBP pfam01161
Phosphatidylethanolamine-binding protein;
50-166 1.65e-16

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 71.99  E-value: 1.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  50 PEVKWDAEP--GALYTLIKTDPDAPSRKEPTyreWHHWLVVNIPGN--DIAKG-----------DTLSEYIGAGPPPKTG 114
Cdd:pfam01161  15 PPLAWSGAPagTKSFALVMIDPDAPKVGGSG---WLHWVVTNIPATvtELPEGapagavqglndFGGAGYGGPCPPAGDG 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1972289472 115 LHRYVYLIYKQSgriedaehgrlTNTSGDKRGGWKAADFVA--KHKLG-APVFGN 166
Cdd:pfam01161  92 PHRYVFTLYALD-----------VPLLDRNWGFTKAELGVAfaGHVLAlAVLAGN 135
PEBP COG1881
Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family ...
 50-123 2.37e-08

Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family [General function prediction only];


Pssm-ID: 441485  Cd Length: 151  Bit Score: 50.54  E-value: 2.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  50 PEVKW-DAEPGAL-YTLIKTDPDAPsrkepTYREWHHWLVVNIPGN------DIAKGDTLSE------------YIGAGP 109
Cdd:COG1881    27 PPLSWsGAPEGTKsFALIVEDPDAP-----TGGGFWHWVVYNIPADvtelpeGAGSADLPAGavqgrndfgeagYGGPCP 101

                          90
                  ....*....|....
gi 1972289472 110 PPKTGLHRYVYLIY 123
Cdd:COG1881   102 PPGDGPHRYVFTVY 115
TIGR00481 TIGR00481
Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]
 49-123 9.88e-05

Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]


Pssm-ID: 129572  Cd Length: 141  Bit Score: 40.54  E-value: 9.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  49 TPEVKWDAEPGAL--YTLIKTDPDAPsrkepTYREWHHWLVVNIP-------------GNDIAKGDTLSE--------YI 105
Cdd:TIGR00481  15 SPPLSWDGVPEGAksLALTCIDPDAP-----TGCGWWHWVVVNIPadttvlpenassdDKRLPQGVPLQGrndfgksgYI 89

                          90
                  ....*....|....*...
gi 1972289472 106 GAGPPpkTGLHRYVYLIY 123
Cdd:TIGR00481  90 GPCPP--KGDHRYLFTVY 105
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 23-170 5.91e-61

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 186.43  E-value: 5.91e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  23 KVVSVKFNSGVEANLGNVLTPTQVKDTPEVKWDAE--PGALYTLIKTDPDAPSRKEPTYREWHHWLVVNIPGND-----I 95
Cdd:cd00866     1 VDLTVSYGSSGVVTPGNLLTPSETQKAPTVSFSSEdpPDKLYTLVMVDPDAPSRDDPKFREWLHWLVTNIPGSDtttglV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972289472  96 AKGDTLSEYIGAGPPPKTGLHRYVYLIYKQSGRIEDAEHgRLTNTSGDKRGGWKAADFVAKHKLGAPVFGNLFQA 170
Cdd:cd00866    81 SKGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPES-KLPPTSGLGRRGFDVREFAKKNGLGLPVAANFFQV 154
PEBP cd00457
PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding ...
 36-161 2.97e-24

PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). A number of biological roles for members of the PEBP family include serine protease inhibition, membrane biogenesis, regulation of flowering plant stem architecture, and Raf-1 kinase inhibition. Although their overall structures are similar, the members of the PEBP family bind very different substrates including phospholipids, opioids, and hydrophobic odorant molecules as well as having different oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176642  Cd Length: 159  Bit Score: 92.84  E-value: 2.97e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  36 NLGNVLTP----TQVKDTPEVKWDAEP--GALYTLIKTDPDAPsrkepTYREWHHWLVVNIPGNDIA------------- 96
Cdd:cd00457     9 PSGSVLPPeysfEGVGRFPSLSWDGPPpdVKEYVLVMEDPDAP-----LGRPIVHGLVYGIPANKTSlsnddfvvtdngk 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972289472  97 ----------KGDTLSEYIGAGPPPKTGLHRYVYLIYKQSGRIEDAEhgrltntSGDKRGGWKAADFVAKHKLGA 161
Cdd:cd00457    84 gglqggfkygKNRGGTVYIGPRPPLGHGPHRYFFQVYALDEPLDRSK-------LGDGRTKFEVARFAEGNVLGA 151
PLN00169 PLN00169
CETS family protein; Provisional
 11-163 3.70e-20

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 82.55  E-value: 3.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  11 VIPDVLasNPPSKVVSVKFNSGV-EANLGNVLTPTQVKDTPEVKWDAEP-GALYTLIKTDPDAPSRKEPTYREWHHWLVV 88
Cdd:PLN00169   14 VVGDVL--DPFTRSISLRVTYGSrEVNNGCELKPSQVVNQPRVDIGGEDlRTFYTLVMVDPDAPSPSNPNLREYLHWLVT 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972289472  89 NIPGNDIAK-GDTLSEYigAGPPPKTGLHRYVYLIYKQSgriedaehGRLTNTSGDKRGGWKAADFVAKHKLGAPV 163
Cdd:PLN00169   92 DIPATTGATfGQEVVCY--ESPRPTAGIHRFVFVLFRQL--------GRQTVYAPGWRQNFNTRDFAELYNLGSPV 157
PBP pfam01161
Phosphatidylethanolamine-binding protein;
50-166 1.65e-16

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 71.99  E-value: 1.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  50 PEVKWDAEP--GALYTLIKTDPDAPSRKEPTyreWHHWLVVNIPGN--DIAKG-----------DTLSEYIGAGPPPKTG 114
Cdd:pfam01161  15 PPLAWSGAPagTKSFALVMIDPDAPKVGGSG---WLHWVVTNIPATvtELPEGapagavqglndFGGAGYGGPCPPAGDG 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1972289472 115 LHRYVYLIYKQSgriedaehgrlTNTSGDKRGGWKAADFVA--KHKLG-APVFGN 166
Cdd:pfam01161  92 PHRYVFTLYALD-----------VPLLDRNWGFTKAELGVAfaGHVLAlAVLAGN 135
PEBP COG1881
Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family ...
 50-123 2.37e-08

Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family [General function prediction only];


Pssm-ID: 441485  Cd Length: 151  Bit Score: 50.54  E-value: 2.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  50 PEVKW-DAEPGAL-YTLIKTDPDAPsrkepTYREWHHWLVVNIPGN------DIAKGDTLSE------------YIGAGP 109
Cdd:COG1881    27 PPLSWsGAPEGTKsFALIVEDPDAP-----TGGGFWHWVVYNIPADvtelpeGAGSADLPAGavqgrndfgeagYGGPCP 101

                          90
                  ....*....|....
gi 1972289472 110 PPKTGLHRYVYLIY 123
Cdd:COG1881   102 PPGDGPHRYVFTVY 115
PEBP_bact_arch cd00865
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; ...
 50-123 7.75e-07

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in bacterial and archaea. Members here include Escherichia coli YBHB and YBCL which are thought to regulate protein phosphorylation as well as Sulfolobus solfataricus SsCEI which inhibits serine proteases alpha-chymotrypsin and elastase. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer). In a few of the bacterial members present here the dimerization interface is proposed to form the ligand binding site, unlike in other PEBP members.


Pssm-ID: 176643  Cd Length: 150  Bit Score: 46.44  E-value: 7.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  50 PEVKW-DAEPGAL-YTLIKTDPDAPsrkepTYREWHHWLVVNIPGN------DIAKGDTLSEYIGA----------GP-P 110
Cdd:cd00865    28 PPLSWsGVPAGTKsLALIVEDPDAP-----TGGGFVHWVVWNIPADttelpeGASRGALPAGAVQGrndfgeagygGPcP 102

                          90
                  ....*....|...
gi 1972289472 111 PKTGLHRYVYLIY 123
Cdd:cd00865   103 PDGGPHRYVFTVY 115
PRK10257 PRK10257
putative kinase inhibitor protein; Provisional
 49-123 4.37e-05

putative kinase inhibitor protein; Provisional


Pssm-ID: 182339  Cd Length: 158  Bit Score: 41.68  E-value: 4.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  49 TPEVKWDAEPGALYTLIKT--DPDAPsrkepTYREWHHWLVVNIPGN-------------DIAKG--DTLSEYIGAG--- 108
Cdd:PRK10257   31 SPHLAWDDVPAGTKSFVVTcyDPDAP-----TGSGWWHWVVVNLPADtrvlpqgfgsglvALPDGvlQTRTDFGKAGygg 105

                          90
                  ....*....|....*.
gi 1972289472 109 -PPPKTGLHRYVYLIY 123
Cdd:PRK10257  106 aAPPKGETHRYIFTVH 121
TIGR00481 TIGR00481
Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]
 49-123 9.88e-05

Raf kinase inhibitor-like protein, YbhB/YbcL family; [Unknown function, General]


Pssm-ID: 129572  Cd Length: 141  Bit Score: 40.54  E-value: 9.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  49 TPEVKWDAEPGAL--YTLIKTDPDAPsrkepTYREWHHWLVVNIP-------------GNDIAKGDTLSE--------YI 105
Cdd:TIGR00481  15 SPPLSWDGVPEGAksLALTCIDPDAP-----TGCGWWHWVVVNIPadttvlpenassdDKRLPQGVPLQGrndfgksgYI 89

                          90
                  ....*....|....*...
gi 1972289472 106 GAGPPpkTGLHRYVYLIY 123
Cdd:TIGR00481  90 GPCPP--KGDHRYLFTVY 105
PRK09818 PRK09818
kinase inhibitor;
49-123 4.73e-03

kinase inhibitor;


Pssm-ID: 182092  Cd Length: 183  Bit Score: 36.46  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972289472  49 TPEVKWDAEPGALYTLIKT--DPDAPsrkepTYREWHHWLVVNIP--------GNDIAKGDTL-------------SEYI 105
Cdd:PRK09818   52 SPSLTWSGAPEGTKSFAVTvyDPDAP-----TGSGWWHWTVANIPatvtylpaDAGRRDGTKLptgavqgrndfgyAGFG 126

                          90
                  ....*....|....*...
gi 1972289472 106 GAGPPPKTGLHRYVYLIY 123
Cdd:PRK09818  127 GACPPKGDKPHHYQFKVW 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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