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Conserved domains on  [gi|1972245392|ref|NP_001379746|]
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GyrI-like small molecule binding domain-containing protein [Caenorhabditis elegans]

Protein Classification

GyrI-like domain-containing protein( domain architecture ID 10534197)

GyrI-like domain-containing protein adopts a beta-barrel fold similar to the effector-binding region of AraC/XylS transcription activators and may bind a small molecule

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GyrI-like pfam06445
GyrI-like small molecule binding domain; This family contains the small molecule binding ...
 43-189 2.42e-09

GyrI-like small molecule binding domain; This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.


:

Pssm-ID: 428947  Cd Length: 153  Bit Score: 54.34  E-value: 2.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972245392  43 KPLTVYYKYHLGPYQ--NVMNVIGEAKQLLAS---SPTPATFFGIYYDNPEVTDSHFLQSAVGVVFgSDGNDFHSEKYSK 117
Cdd:pfam06445   8 PAFRVAGLRHRGPYNeeGIGALWEELCAWASEnglSPAPSPLIGVSYDDPEVTEDEELRYDAGVAV-PIPVEGPEGVEEL 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1972245392 118 DLTdnGFEKLVLPNVERAVQVtqPSTGGFASFLALVWFTYSTIRKYISENKLETTYAVEfYTNTEINVIFPL 189
Cdd:pfam06445  87 ELP--GGEYAVFRHKGPYDDL--QETYAKIYGEWLPESGYERRDGPSFEIYLNDPREVP-EEELKTEIYIPV 153
 
Name Accession Description Interval E-value
GyrI-like pfam06445
GyrI-like small molecule binding domain; This family contains the small molecule binding ...
 43-189 2.42e-09

GyrI-like small molecule binding domain; This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.


Pssm-ID: 428947  Cd Length: 153  Bit Score: 54.34  E-value: 2.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972245392  43 KPLTVYYKYHLGPYQ--NVMNVIGEAKQLLAS---SPTPATFFGIYYDNPEVTDSHFLQSAVGVVFgSDGNDFHSEKYSK 117
Cdd:pfam06445   8 PAFRVAGLRHRGPYNeeGIGALWEELCAWASEnglSPAPSPLIGVSYDDPEVTEDEELRYDAGVAV-PIPVEGPEGVEEL 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1972245392 118 DLTdnGFEKLVLPNVERAVQVtqPSTGGFASFLALVWFTYSTIRKYISENKLETTYAVEfYTNTEINVIFPL 189
Cdd:pfam06445  87 ELP--GGEYAVFRHKGPYDDL--QETYAKIYGEWLPESGYERRDGPSFEIYLNDPREVP-EEELKTEIYIPV 153
SbmC COG3449
DNA gyrase inhibitor GyrI/SbmC [Replication, recombination and repair];
44-106 3.78e-07

DNA gyrase inhibitor GyrI/SbmC [Replication, recombination and repair];


Pssm-ID: 442672 [Multi-domain]  Cd Length: 286  Bit Score: 49.86  E-value: 3.78e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972245392  44 PLTVYYKYHLGPYQNVMNVIGEAKQLLAS---SPTPATFFGIYYDNPEVTDSHFLQSAVGVVFGSD 106
Cdd:COG3449   142 PRRVAYLRHRGPYEEIGEAFERLIAWAKArglLPPDSRTIGIYYDDPDITPPEKLRYDACVTVPED 207
 
Name Accession Description Interval E-value
GyrI-like pfam06445
GyrI-like small molecule binding domain; This family contains the small molecule binding ...
 43-189 2.42e-09

GyrI-like small molecule binding domain; This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.


Pssm-ID: 428947  Cd Length: 153  Bit Score: 54.34  E-value: 2.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972245392  43 KPLTVYYKYHLGPYQ--NVMNVIGEAKQLLAS---SPTPATFFGIYYDNPEVTDSHFLQSAVGVVFgSDGNDFHSEKYSK 117
Cdd:pfam06445   8 PAFRVAGLRHRGPYNeeGIGALWEELCAWASEnglSPAPSPLIGVSYDDPEVTEDEELRYDAGVAV-PIPVEGPEGVEEL 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1972245392 118 DLTdnGFEKLVLPNVERAVQVtqPSTGGFASFLALVWFTYSTIRKYISENKLETTYAVEfYTNTEINVIFPL 189
Cdd:pfam06445  87 ELP--GGEYAVFRHKGPYDDL--QETYAKIYGEWLPESGYERRDGPSFEIYLNDPREVP-EEELKTEIYIPV 153
SbmC COG3449
DNA gyrase inhibitor GyrI/SbmC [Replication, recombination and repair];
44-106 3.78e-07

DNA gyrase inhibitor GyrI/SbmC [Replication, recombination and repair];


Pssm-ID: 442672 [Multi-domain]  Cd Length: 286  Bit Score: 49.86  E-value: 3.78e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972245392  44 PLTVYYKYHLGPYQNVMNVIGEAKQLLAS---SPTPATFFGIYYDNPEVTDSHFLQSAVGVVFGSD 106
Cdd:COG3449   142 PRRVAYLRHRGPYEEIGEAFERLIAWAKArglLPPDSRTIGIYYDDPDITPPEKLRYDACVTVPED 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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