Acyl-CoA dehydrogenase/oxidase N-terminal domain-containing protein [Caenorhabditis elegans]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| ACAD super family | cl09933 | Acyl-CoA dehydrogenase; Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal ... |
38-90 | 2.92e-07 | ||
Acyl-CoA dehydrogenase; Both mitochondrial acyl-CoA dehydrogenases (ACAD) and peroxisomal acyl-CoA oxidases (AXO) catalyze the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of ACAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. In contrast, AXO catalyzes a different oxidative half-reaction, in which the reduced FAD is reoxidized by molecular oxygen. The ACAD family includes the eukaryotic beta-oxidation enzymes, short (SCAD), medium (MCAD), long (LCAD) and very-long (VLCAD) chain acyl-CoA dehydrogenases. These enzymes all share high sequence similarity, but differ in their substrate specificities. The ACAD family also includes amino acid catabolism enzymes such as Isovaleryl-CoA dehydrogenase (IVD), short/branched chain acyl-CoA dehydrogenases(SBCAD), Isobutyryl-CoA dehydrogenase (IBDH), glutaryl-CoA deydrogenase (GCD) and Crotonobetainyl-CoA dehydrogenase. The mitochondrial ACAD's are generally homotetramers, except for VLCAD, which is a homodimer. Related enzymes include the SOS adaptive reponse proten aidB, Naphthocyclinone hydroxylase (NcnH), and and Dibenzothiophene (DBT) desulfurization enzyme C (DszC) The actual alignment was detected with superfamily member cd01158: Pssm-ID: 447864 [Multi-domain] Cd Length: 373 Bit Score: 49.19 E-value: 2.92e-07
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| Name | Accession | Description | Interval | E-value | ||
| SCAD_SBCAD | cd01158 | Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA ... |
38-90 | 2.92e-07 | ||
Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers. Pssm-ID: 173847 [Multi-domain] Cd Length: 373 Bit Score: 49.19 E-value: 2.92e-07
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| Acyl-CoA_dh_N | pfam02771 | Acyl-CoA dehydrogenase, N-terminal domain; The N-terminal domain of Acyl-CoA dehydrogenase is ... |
37-84 | 1.93e-06 | ||
Acyl-CoA dehydrogenase, N-terminal domain; The N-terminal domain of Acyl-CoA dehydrogenase is an all-alpha domain. Pssm-ID: 460686 [Multi-domain] Cd Length: 113 Bit Score: 44.76 E-value: 1.93e-06
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| CaiA | COG1960 | Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and ... |
35-90 | 2.31e-05 | ||
Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]; Acyl-CoA dehydrogenase related to the alkylation response protein AidB is part of the Pathway/BioSystem: Fatty acid biosynthesis Pssm-ID: 441563 [Multi-domain] Cd Length: 381 Bit Score: 43.68 E-value: 2.31e-05
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| Name | Accession | Description | Interval | E-value | ||
| SCAD_SBCAD | cd01158 | Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA ... |
38-90 | 2.92e-07 | ||
Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Short chain acyl-CoA dehydrogenase (SCAD). SCAD is a mitochondrial beta-oxidation enzyme. It catalyzes the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of SCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. This subgroup also contains the eukaryotic short/branched chain acyl-CoA dehydrogenase(SBCAD), the bacterial butyryl-CoA dehydorgenase(BCAD) and 2-methylbutyryl-CoA dehydrogenase, which is involved in isoleucine catabolism. These enzymes are homotetramers. Pssm-ID: 173847 [Multi-domain] Cd Length: 373 Bit Score: 49.19 E-value: 2.92e-07
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| Acyl-CoA_dh_N | pfam02771 | Acyl-CoA dehydrogenase, N-terminal domain; The N-terminal domain of Acyl-CoA dehydrogenase is ... |
37-84 | 1.93e-06 | ||
Acyl-CoA dehydrogenase, N-terminal domain; The N-terminal domain of Acyl-CoA dehydrogenase is an all-alpha domain. Pssm-ID: 460686 [Multi-domain] Cd Length: 113 Bit Score: 44.76 E-value: 1.93e-06
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| CaiA | COG1960 | Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and ... |
35-90 | 2.31e-05 | ||
Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]; Acyl-CoA dehydrogenase related to the alkylation response protein AidB is part of the Pathway/BioSystem: Fatty acid biosynthesis Pssm-ID: 441563 [Multi-domain] Cd Length: 381 Bit Score: 43.68 E-value: 2.31e-05
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| IVD | cd01156 | Isovaleryl-CoA dehydrogenase; Isovaleryl-CoA dehydrogenase (IVD) is an is an acyl-CoA ... |
35-88 | 2.49e-04 | ||
Isovaleryl-CoA dehydrogenase; Isovaleryl-CoA dehydrogenase (IVD) is an is an acyl-CoA dehydrogenase, which catalyzes the third step in leucine catabolism, the conversion of isovaleryl-CoA (3-methylbutyryl-CoA) into 3-methylcrotonyl-CoA. IVD is a homotetramer and has the greatest affinity for small branched chain substrates. Pssm-ID: 173845 [Multi-domain] Cd Length: 376 Bit Score: 40.47 E-value: 2.49e-04
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