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Conserved domains on  [gi|1972238555|ref|NP_001379645|]
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putative Hsp90 co-chaperone cdc37 [Caenorhabditis elegans]

Protein Classification

CDC37_N and CDC37_M domain-containing protein( domain architecture ID 10660770)

protein containing domains CDC37_N, CDC37_M, and CDC37_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 128-273 1.59e-40

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


:

Pssm-ID: 215010  Cd Length: 155  Bit Score: 140.21  E-value: 1.59e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972238555  128 ITEKKPQAPKTDEEDTHAMSTFFETHESLLEKMAVLKNGA-KSTELFLAEHPHMASEYTANWLTIEALNAAIDFNEEKMK 206
Cdd:smart01070   4 TSSKNPPSAPSEEEDEIDDKDFVLKLEPATKKFGMIPAGDyDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEALME 83

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972238555  207 TMAEQCIIIQYLLELSKSLNAVATNTTvqKQFFKKFEA----AEPVYMKHYQDEVKAFEDRLRTRAQTKRD 273
Cdd:smart01070  84 QVAHQAILMQYILELAKSLKVDPRNCV--RLFFQKIKTpshpAKEGFLEDVQSEFEHIKTRVRIIAQEQAE 152
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 2-123 1.87e-29

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


:

Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 110.97  E-value: 1.87e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972238555    2 PIDYSKWKDIEVSDDED-DTHPNIDTPSLFRWR----HQARLERMAEKK-------------MEQEKIDK---------E 54
Cdd:smart01071   1 PIDYSKWDKIELSDDSDiEVHPNVDKKSFIRWKqrdiHQARVERMEEIKnlkyelimndhlnKRIDKLLKglreeelspE 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972238555   55 KGTTSKKMEELEKKLAAADVTDKSD-------IQKQIDEVKAQEEAWRKKEAELEEKERLEPWNVDTigHEAFSTS 123
Cdd:smart01071  81 TPTYNEMLAELQDQLKKELEEANGDseglleeLKKHRDKLKKEQKELRKKLDELEKEEKKKIWSVDT--HTGFDKS 154
CDC37_C smart01069
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 292-349 9.61e-16

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37.


:

Pssm-ID: 215009  Cd Length: 93  Bit Score: 72.05  E-value: 9.61e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972238555  292 PGGI--DPQEVFEQLPEEMRKCFEAHDIEALKGVAQKMDEEVFKYHFDRCIASGLW-VPGK 349
Cdd:smart01069   3 PGGLslDPEEVFESLPPELQKAFETKDLDMLNKVLAKMPVEEAEYHLERCIESGLWgVPNA 63
 
Name Accession Description Interval E-value
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 128-273 1.59e-40

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


Pssm-ID: 215010  Cd Length: 155  Bit Score: 140.21  E-value: 1.59e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972238555  128 ITEKKPQAPKTDEEDTHAMSTFFETHESLLEKMAVLKNGA-KSTELFLAEHPHMASEYTANWLTIEALNAAIDFNEEKMK 206
Cdd:smart01070   4 TSSKNPPSAPSEEEDEIDDKDFVLKLEPATKKFGMIPAGDyDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEALME 83

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972238555  207 TMAEQCIIIQYLLELSKSLNAVATNTTvqKQFFKKFEA----AEPVYMKHYQDEVKAFEDRLRTRAQTKRD 273
Cdd:smart01070  84 QVAHQAILMQYILELAKSLKVDPRNCV--RLFFQKIKTpshpAKEGFLEDVQSEFEHIKTRVRIIAQEQAE 152
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 2-123 1.87e-29

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 110.97  E-value: 1.87e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972238555    2 PIDYSKWKDIEVSDDED-DTHPNIDTPSLFRWR----HQARLERMAEKK-------------MEQEKIDK---------E 54
Cdd:smart01071   1 PIDYSKWDKIELSDDSDiEVHPNVDKKSFIRWKqrdiHQARVERMEEIKnlkyelimndhlnKRIDKLLKglreeelspE 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972238555   55 KGTTSKKMEELEKKLAAADVTDKSD-------IQKQIDEVKAQEEAWRKKEAELEEKERLEPWNVDTigHEAFSTS 123
Cdd:smart01071  81 TPTYNEMLAELQDQLKKELEEANGDseglleeLKKHRDKLKKEQKELRKKLDELEKEEKKKIWSVDT--HTGFDKS 154
CDC37_C smart01069
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 292-349 9.61e-16

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37.


Pssm-ID: 215009  Cd Length: 93  Bit Score: 72.05  E-value: 9.61e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972238555  292 PGGI--DPQEVFEQLPEEMRKCFEAHDIEALKGVAQKMDEEVFKYHFDRCIASGLW-VPGK 349
Cdd:smart01069   3 PGGLslDPEEVFESLPPELQKAFETKDLDMLNKVLAKMPVEEAEYHLERCIESGLWgVPNA 63
CDC37_M pfam08565
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 173-268 1.14e-10

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain pfam03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 pfam08564 whose function is unclear.


Pssm-ID: 430078  Cd Length: 113  Bit Score: 58.36  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972238555 173 FLAEHPHMASEYTANWLTIEALNAAIDFNEEKMKTMAEQCIIIQYLLELSKSLNAVatnttvqKQFFKKFEAAEPVYMKH 252
Cdd:pfam08565  16 FLLKHPEILSEQQKDALLMEAFDAQLEGKTKYARQCVHQSLLLQYCRQLDGRINGV-------KLFFKRITTKDHQAKKL 88

                          90
                  ....*....|....*.
gi 1972238555 253 YQDEVKAFEDRLRTRA 268
Cdd:pfam08565  89 FLDDVQSTYNHIKTRA 104
CDC37_N pfam03234
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 7-86 3.04e-07

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain pfam08565. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 427208 [Multi-domain]  Cd Length: 124  Bit Score: 48.76  E-value: 3.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972238555   7 KWKDIEVSDDED-DTHPNIDTPSLFRWR----HQARLERMAE-KKMEQEKIDKEKgtTSKKMEELEKKLAAADVTDKSDI 80
Cdd:pfam03234   1 KWDALELSDDSDiEVHPNVDKRSFIRWKqrdiHEKREQRKAEiKTLKYERIMNDG--LLKRIDKLLTALKKHGVESDEVV 78


                  ....*.
gi 1972238555  81 QKQIDE 86
Cdd:pfam03234  79 FQALME 84
CDC37_C pfam08564
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 292-345 9.75e-07

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37 pfam03234.


Pssm-ID: 430077  Cd Length: 87  Bit Score: 46.17  E-value: 9.75e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1972238555 292 PGGIDPQEVFEQLPEEMRKCFEAHDIEALKGVAQKMDEEVFKYHFDRCIASGLW 345
Cdd:pfam08564  10 PEEQKAVEIFESLPPEMQKALKTKSLDEVNKVLGKMPVEEAEEIVELFGEAGIL 63
 
Name Accession Description Interval E-value
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 128-273 1.59e-40

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


Pssm-ID: 215010  Cd Length: 155  Bit Score: 140.21  E-value: 1.59e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972238555  128 ITEKKPQAPKTDEEDTHAMSTFFETHESLLEKMAVLKNGA-KSTELFLAEHPHMASEYTANWLTIEALNAAIDFNEEKMK 206
Cdd:smart01070   4 TSSKNPPSAPSEEEDEIDDKDFVLKLEPATKKFGMIPAGDyDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEALME 83

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972238555  207 TMAEQCIIIQYLLELSKSLNAVATNTTvqKQFFKKFEA----AEPVYMKHYQDEVKAFEDRLRTRAQTKRD 273
Cdd:smart01070  84 QVAHQAILMQYILELAKSLKVDPRNCV--RLFFQKIKTpshpAKEGFLEDVQSEFEHIKTRVRIIAQEQAE 152
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 2-123 1.87e-29

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 110.97  E-value: 1.87e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972238555    2 PIDYSKWKDIEVSDDED-DTHPNIDTPSLFRWR----HQARLERMAEKK-------------MEQEKIDK---------E 54
Cdd:smart01071   1 PIDYSKWDKIELSDDSDiEVHPNVDKKSFIRWKqrdiHQARVERMEEIKnlkyelimndhlnKRIDKLLKglreeelspE 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972238555   55 KGTTSKKMEELEKKLAAADVTDKSD-------IQKQIDEVKAQEEAWRKKEAELEEKERLEPWNVDTigHEAFSTS 123
Cdd:smart01071  81 TPTYNEMLAELQDQLKKELEEANGDseglleeLKKHRDKLKKEQKELRKKLDELEKEEKKKIWSVDT--HTGFDKS 154
CDC37_C smart01069
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 292-349 9.61e-16

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37.


Pssm-ID: 215009  Cd Length: 93  Bit Score: 72.05  E-value: 9.61e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972238555  292 PGGI--DPQEVFEQLPEEMRKCFEAHDIEALKGVAQKMDEEVFKYHFDRCIASGLW-VPGK 349
Cdd:smart01069   3 PGGLslDPEEVFESLPPELQKAFETKDLDMLNKVLAKMPVEEAEYHLERCIESGLWgVPNA 63
CDC37_M pfam08565
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 173-268 1.14e-10

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain pfam03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 pfam08564 whose function is unclear.


Pssm-ID: 430078  Cd Length: 113  Bit Score: 58.36  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972238555 173 FLAEHPHMASEYTANWLTIEALNAAIDFNEEKMKTMAEQCIIIQYLLELSKSLNAVatnttvqKQFFKKFEAAEPVYMKH 252
Cdd:pfam08565  16 FLLKHPEILSEQQKDALLMEAFDAQLEGKTKYARQCVHQSLLLQYCRQLDGRINGV-------KLFFKRITTKDHQAKKL 88

                          90
                  ....*....|....*.
gi 1972238555 253 YQDEVKAFEDRLRTRA 268
Cdd:pfam08565  89 FLDDVQSTYNHIKTRA 104
CDC37_N pfam03234
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 7-86 3.04e-07

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain pfam08565. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 427208 [Multi-domain]  Cd Length: 124  Bit Score: 48.76  E-value: 3.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972238555   7 KWKDIEVSDDED-DTHPNIDTPSLFRWR----HQARLERMAE-KKMEQEKIDKEKgtTSKKMEELEKKLAAADVTDKSDI 80
Cdd:pfam03234   1 KWDALELSDDSDiEVHPNVDKRSFIRWKqrdiHEKREQRKAEiKTLKYERIMNDG--LLKRIDKLLTALKKHGVESDEVV 78


                  ....*.
gi 1972238555  81 QKQIDE 86
Cdd:pfam03234  79 FQALME 84
CDC37_C pfam08564
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 292-345 9.75e-07

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37 pfam03234.


Pssm-ID: 430077  Cd Length: 87  Bit Score: 46.17  E-value: 9.75e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1972238555 292 PGGIDPQEVFEQLPEEMRKCFEAHDIEALKGVAQKMDEEVFKYHFDRCIASGLW 345
Cdd:pfam08564  10 PEEQKAVEIFESLPPEMQKALKTKSLDEVNKVLGKMPVEEAEEIVELFGEAGIL 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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