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Conserved domains on  [gi|1972260667|ref|NP_001379577|]
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Microtubule-associated protein [Caenorhabditis elegans]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 219-247 8.65e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 47.02  E-value: 8.65e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 1972260667 219 VKIVSEKLTW-QAKSKVGSMDNAAHKPAGG 247
Cdd:pfam00418   1 VKIESKKLDFsKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 160-188 1.76e-05

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 40.47  E-value: 1.76e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1972260667 160 VEIFSEK-RLYNAQSKVGSLKNATHVAGGG 188
Cdd:pfam00418   1 VKIESKKlDFSKVQSKCGSKDNIKHKPGGG 30
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 43-157 4.37e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 38.36  E-value: 4.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972260667  43 MSPTPSQPQHKTPQRS-GIRPPTAILRQPKPiPASLPRPATATPSSQRAISTPRQTASTAPSPRPISKMSRERSDVQKST 121
Cdd:pfam05109 488 VTPSPSPRDNGTESKApDMTSPTSAVTTPTP-NATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPT 566

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1972260667 122 STRSIDNVGRM---------TPKVNAKFVNVKSKVGSVTNHKAGG 157
Cdd:pfam05109 567 PNATIPTLGKTsptsavttpTPNATSPTVGETSPQANTTNHTLGG 611
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 219-247 8.65e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 47.02  E-value: 8.65e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 1972260667 219 VKIVSEKLTW-QAKSKVGSMDNAAHKPAGG 247
Cdd:pfam00418   1 VKIESKKLDFsKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 160-188 1.76e-05

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 40.47  E-value: 1.76e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1972260667 160 VEIFSEK-RLYNAQSKVGSLKNATHVAGGG 188
Cdd:pfam00418   1 VKIESKKlDFSKVQSKCGSKDNIKHKPGGG 30
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 43-157 4.37e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 38.36  E-value: 4.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972260667  43 MSPTPSQPQHKTPQRS-GIRPPTAILRQPKPiPASLPRPATATPSSQRAISTPRQTASTAPSPRPISKMSRERSDVQKST 121
Cdd:pfam05109 488 VTPSPSPRDNGTESKApDMTSPTSAVTTPTP-NATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPT 566

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1972260667 122 STRSIDNVGRM---------TPKVNAKFVNVKSKVGSVTNHKAGG 157
Cdd:pfam05109 567 PNATIPTLGKTsptsavttpTPNATSPTVGETSPQANTTNHTLGG 611
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 44-106 8.40e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 37.10  E-value: 8.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1972260667  44 SPTPSQPQHKTPQRSGIRPPTAILRQPKPIPASLPRPATATPSSQRAISTPRQTASTAPSPRP 106
Cdd:PRK14950  370 KPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLT 432
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 219-247 8.65e-08

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 47.02  E-value: 8.65e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 1972260667 219 VKIVSEKLTW-QAKSKVGSMDNAAHKPAGG 247
Cdd:pfam00418   1 VKIESKKLDFsKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 160-188 1.76e-05

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 40.47  E-value: 1.76e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1972260667 160 VEIFSEK-RLYNAQSKVGSLKNATHVAGGG 188
Cdd:pfam00418   1 VKIESKKlDFSKVQSKCGSKDNIKHKPGGG 30
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 43-157 4.37e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 38.36  E-value: 4.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972260667  43 MSPTPSQPQHKTPQRS-GIRPPTAILRQPKPiPASLPRPATATPSSQRAISTPRQTASTAPSPRPISKMSRERSDVQKST 121
Cdd:pfam05109 488 VTPSPSPRDNGTESKApDMTSPTSAVTTPTP-NATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPT 566

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1972260667 122 STRSIDNVGRM---------TPKVNAKFVNVKSKVGSVTNHKAGG 157
Cdd:pfam05109 567 PNATIPTLGKTsptsavttpTPNATSPTVGETSPQANTTNHTLGG 611
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 44-106 8.40e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 37.10  E-value: 8.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1972260667  44 SPTPSQPQHKTPQRSGIRPPTAILRQPKPIPASLPRPATATPSSQRAISTPRQTASTAPSPRP 106
Cdd:PRK14950  370 KPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLT 432
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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