|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
970-1261 |
1.18e-134 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
:
Pssm-ID: 239227 Cd Length: 292 Bit Score: 416.98 E-value: 1.18e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 970 VLNNAHKLVQMPYGCGEQNMLNLVPNILVVKYLRATNRNESQLETKAIKFIEQGIQRELTYKRADNSFSAFGDSDKAGST 1049
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1050 WLTAFVVRSFHHAKQYAFVDPNVISRAVAFLNSQQMESGAFAERGEVHHKDMQGGaQDGGVALTAFVLISILENGMENG- 1128
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGG-VDDEVALTAYVLIALLEAGLPSEr 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1129 ----KAVTYLEKHLDEVSgNAYTMAVVAYALQLAKSKQAGKAFENLKKHKIVEKSGDVKfasaqKKVEKLKESRAYMFQA 1204
Cdd:cd02897 160 pvveKALSCLEAALDSIS-DPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHW-----SRPPPSEEGPSYYWQA 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1972236247 1205 RPVDIETTSYAVLSYLAQNQ--TSESLSIIRWLVSQRNELGGFTSTQDTVMALQALSSY 1261
Cdd:cd02897 234 PSAEVEMTAYALLALLSAGGedLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| YfaS super family |
cl34462 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
139-1334 |
5.13e-73 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
The actual alignment was detected with superfamily member COG2373:
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 270.03 E-value: 5.13e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 139 DQKALSVFIQTDRAIYRPASLVRYRAIVVKSDLKPYVG-NATIKIFDPSRNLISQTIGVTLDRGVYSGELQLAEETLLGD 217
Cdd:COG2373 365 PPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGlPLTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGT 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 218 WFIEVETSNGVQDKS-SFTVDTYVLPKFEVNIKTSS-FITINDDLSVFVDAKYTYGKGVAG---KAKVSLELPWHRWHAM 292
Cdd:COG2373 445 WRLELYVDPKPALGSkSFRVEEFKPPRFKVDLTLDKePLKPGDPVTVTVDARYLFGAPAAGlkvEGEVTLRPARTAFPGY 524
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 293 VPTIIDENGVKKEEELMVERTVKLNRQGEAAVVFSNDELKRHKLLHEwgggsIRIVASVTEDiT--EIERNATHQISTFR 370
Cdd:COG2373 525 PGYRFGDPDEEFEPEELDLGEGTLDADGKASLSLPLPDAPDAPGPLR-----ATVEASVFES-GgrPVTRSATVPVHPAD 598
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 371 EEV-----KLDVEKQGDTFKPGLtynVVV--ALKQMDDTPVKATLPKRVQVSTFYNYPYN--HDTSSLQEEK-ETKIVEV 440
Cdd:COG2373 599 FYVgirlpLFDGDPEGAPATFEV---VAVdpDGKPVAGKGLKVELYREEWRYVWYKSDDGgwRYESQEKEEPvAEGTLTT 675
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 441 DAHGTSVLTLQPPincTSA--RIEAHYDIGGKdnFTATPIYSSlYVEAAVSPTKSFLQLLADNEgAVDVGKSLSFSLKAT 518
Cdd:COG2373 676 GADGPASLSLTPV---EWGryRLEVKDPDGGL--ATSVRFYAG-GNASWGAERPDRLELSLDKE-SYKPGETAKLLIQSP 748
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 519 QP---LSTITyqvmsRSNIVVSQQMTVNSEHATISFPATANMAP---------------KSRLIVYAIieSSQEVLVDAL 580
Cdd:COG2373 749 FAgraLVTVE-----RDGVLETQWVDVKGGGTTVEIPVTEDWAPnayvsatlvrpgdstANDMPARAY--GVAPLPVDPP 821
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 581 DFKVegifqnQVALSIDKQaVEPGQNVKFKVTSD----KNSFVGLLVVDQSVLllktgnDITREKVeqdlenydsnnvgg 656
Cdd:COG2373 822 ARRL------KVELTAPEK-LRPGETLTVTVKVKgaagKAAEVTLAAVDEGIL------NLTGYKT-------------- 874
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 657 gfggPRPWEAIDRKKRSiwrpwwgigGSDAQSIFsnaglvvltDALLyrepqrEFMSVMMMDGAPGMAEAAfaappmgGS 736
Cdd:COG2373 875 ----PDPLDFFYGKRAL---------GVETRDLY---------GRLI------GAFGGAAGALRSGGDGAL-------GR 919
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 737 SPPPPTVRKFFPHTWIWS---DLNStSGEVEMEIEAPDTITSW----VASTfaineENGLGVAptTSKLRVFRPFFIQLN 809
Cdd:COG2373 920 GGNPKPPRKRFKPVALFSgpvKTDA-DGKATVSFDLPDFNGTLrvmaVAWS-----DDRFGSA--EATVTVRKPLVVRPS 991
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 810 LPYAVRRGEKFALLVLVFNYMEKEQDVTVTLKYDkdsgyDLLKKDGTVVRRdevgqqnvriVSVAGGGtSKAVYFPIVPS 889
Cdd:COG2373 992 LPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEAS-----GGLTLEGEATQT----------VTLAAGG-RATVRFPLKAP 1055
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 890 SIGEIPVHISAIASQGGDAVEMNLRVDPQGYKVDRNIPFVIDlNNNSSDFSKNLeliwPNDVVDGSQKARLDVIGDMMGP 969
Cdd:COG2373 1056 DAGDAKVTVTATGGGESDAREVELPVRPANPLVTRATSGVLA-PGESWTLPLDL----PGGLRPGTGSLTLSLSSSPPLD 1130
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 970 VLNNAHKLVQMPYGCGEQNMLNLVPNILVVKYLRATNRNESQLEtKAIKFIEQGIQRELTYKRADNSFSAFGDSDKAgST 1049
Cdd:COG2373 1131 LAGLLRYLLRYPYGCTEQTTSRALPLLYLSDLAEALGLKGDKDA-ELRARIQAAIARLLSMQNSDGGFGLWPGGSES-DP 1208
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1050 WLTAFVVRSFHHAKQYAF-VDPNVISRAVAFLNSQqmesgaFAERGEVHHKDMQGGAQdggVALTAFVLisilengMENG 1128
Cdd:COG2373 1209 WLTAYATDFLLEAREAGYaVPDDALDRALDYLRNY------LRNPWEIEYDDAYRLAV---RAYALYVL-------ARAG 1272
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1129 KAVT-----YLEKHLDEVSGNAYTMAVVAYALqLAKSKQAGKAFENLKKHKIVEKSGDvkfasaqkkveklkESRAYMFQ 1203
Cdd:COG2373 1273 KADLgdlryLYDRRKDALSPLAKAQLAAALAL-LGDKARAEELLAAALARLRETGARD--------------YWYGDYGS 1337
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1204 arpvDIETTSYAVLSYLAQNQTSESLS-IIRWLVSQRNElGGFTSTQDTVMALQALSSYAAvTYSDKHTSQVTI-LNGKh 1281
Cdd:COG2373 1338 ----PLRDQALALALLAELGPDAPLAPkLARWLAKALKS-GRWLSTQETAWALLALAAYAR-AAGASPDFTATLtLDGK- 1410
|
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|....
gi 1972236247 1282 thSFDINIRNAIVLQSYQLSSLNDA-VSINANGTGVVFAQLSYSYYRDSLNDDA 1334
Cdd:COG2373 1411 --TLPLTGRGPLARVTLPAAELLAGpLTITNTGDGPLYYTLTLSGYPAEGPPPA 1462
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1363-1454 |
1.44e-20 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
:
Pssm-ID: 462226 Cd Length: 92 Bit Score: 87.63 E-value: 1.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1363 GKSNMALAEIDALSGYRFDAEQVHTLTSIEDLQRVEMEkDDTKMNVYFNPLGGRPVCLSLYSDVTYQVADQKPANFRLVD 1442
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETV-DDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYD 79
|
90
....*....|..
gi 1972236247 1443 YYDPEEQLKMTY 1454
Cdd:pfam07677 80 YYEPERRATTFY 91
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
970-1261 |
1.18e-134 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 416.98 E-value: 1.18e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 970 VLNNAHKLVQMPYGCGEQNMLNLVPNILVVKYLRATNRNESQLETKAIKFIEQGIQRELTYKRADNSFSAFGDSDKAGST 1049
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1050 WLTAFVVRSFHHAKQYAFVDPNVISRAVAFLNSQQMESGAFAERGEVHHKDMQGGaQDGGVALTAFVLISILENGMENG- 1128
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGG-VDDEVALTAYVLIALLEAGLPSEr 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1129 ----KAVTYLEKHLDEVSgNAYTMAVVAYALQLAKSKQAGKAFENLKKHKIVEKSGDVKfasaqKKVEKLKESRAYMFQA 1204
Cdd:cd02897 160 pvveKALSCLEAALDSIS-DPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHW-----SRPPPSEEGPSYYWQA 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1972236247 1205 RPVDIETTSYAVLSYLAQNQ--TSESLSIIRWLVSQRNELGGFTSTQDTVMALQALSSY 1261
Cdd:cd02897 234 PSAEVEMTAYALLALLSAGGedLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
962-1261 |
1.93e-102 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 330.03 E-value: 1.93e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 962 VIGDMMGPVL----NNAHKLVQMPYGCGEQNMLNLVPNILVVKYLRATNRNESQLETKAIKFIEQGIQRELTYKRADNSF 1037
Cdd:pfam07678 3 VVGDIMGPAIqvvpENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDGSY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1038 SAFGDSDkaGSTWLTAFVVRSFHHAKQYAFVDPNVISRAVAFLNSQQMESGAFAERGEVHHKDMQGGAqDGGVALTAFVL 1117
Cdd:pfam07678 83 SAFGHSP--GSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGV-DGEVSLTAYVT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1118 ISILENGMENG----------KAVTYLEKHLDEVSGNAYTMAVVAYALQLAKS-KQAGKAFENLkkHKIVEKSGDVKFAS 1186
Cdd:pfam07678 160 IALLEALDINGllqrvhpsirKALTYLEQAQLAGLTSPYTLAILAYALALAGSpETREELLKSL--DAMAREEGNSRYWE 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972236247 1187 AQKKVEKlKESRAYMFQARPVDIETTSYAVLSYLAQNQTSESLSIIRWLVSQRNELGGFTSTQDTVMALQALSSY 1261
Cdd:pfam07678 238 RDEKSDP-QGVPEYPPQAPSLEVETTAYALLAYLLLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
139-1334 |
5.13e-73 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 270.03 E-value: 5.13e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 139 DQKALSVFIQTDRAIYRPASLVRYRAIVVKSDLKPYVG-NATIKIFDPSRNLISQTIGVTLDRGVYSGELQLAEETLLGD 217
Cdd:COG2373 365 PPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGlPLTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGT 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 218 WFIEVETSNGVQDKS-SFTVDTYVLPKFEVNIKTSS-FITINDDLSVFVDAKYTYGKGVAG---KAKVSLELPWHRWHAM 292
Cdd:COG2373 445 WRLELYVDPKPALGSkSFRVEEFKPPRFKVDLTLDKePLKPGDPVTVTVDARYLFGAPAAGlkvEGEVTLRPARTAFPGY 524
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 293 VPTIIDENGVKKEEELMVERTVKLNRQGEAAVVFSNDELKRHKLLHEwgggsIRIVASVTEDiT--EIERNATHQISTFR 370
Cdd:COG2373 525 PGYRFGDPDEEFEPEELDLGEGTLDADGKASLSLPLPDAPDAPGPLR-----ATVEASVFES-GgrPVTRSATVPVHPAD 598
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 371 EEV-----KLDVEKQGDTFKPGLtynVVV--ALKQMDDTPVKATLPKRVQVSTFYNYPYN--HDTSSLQEEK-ETKIVEV 440
Cdd:COG2373 599 FYVgirlpLFDGDPEGAPATFEV---VAVdpDGKPVAGKGLKVELYREEWRYVWYKSDDGgwRYESQEKEEPvAEGTLTT 675
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 441 DAHGTSVLTLQPPincTSA--RIEAHYDIGGKdnFTATPIYSSlYVEAAVSPTKSFLQLLADNEgAVDVGKSLSFSLKAT 518
Cdd:COG2373 676 GADGPASLSLTPV---EWGryRLEVKDPDGGL--ATSVRFYAG-GNASWGAERPDRLELSLDKE-SYKPGETAKLLIQSP 748
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 519 QP---LSTITyqvmsRSNIVVSQQMTVNSEHATISFPATANMAP---------------KSRLIVYAIieSSQEVLVDAL 580
Cdd:COG2373 749 FAgraLVTVE-----RDGVLETQWVDVKGGGTTVEIPVTEDWAPnayvsatlvrpgdstANDMPARAY--GVAPLPVDPP 821
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 581 DFKVegifqnQVALSIDKQaVEPGQNVKFKVTSD----KNSFVGLLVVDQSVLllktgnDITREKVeqdlenydsnnvgg 656
Cdd:COG2373 822 ARRL------KVELTAPEK-LRPGETLTVTVKVKgaagKAAEVTLAAVDEGIL------NLTGYKT-------------- 874
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 657 gfggPRPWEAIDRKKRSiwrpwwgigGSDAQSIFsnaglvvltDALLyrepqrEFMSVMMMDGAPGMAEAAfaappmgGS 736
Cdd:COG2373 875 ----PDPLDFFYGKRAL---------GVETRDLY---------GRLI------GAFGGAAGALRSGGDGAL-------GR 919
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 737 SPPPPTVRKFFPHTWIWS---DLNStSGEVEMEIEAPDTITSW----VASTfaineENGLGVAptTSKLRVFRPFFIQLN 809
Cdd:COG2373 920 GGNPKPPRKRFKPVALFSgpvKTDA-DGKATVSFDLPDFNGTLrvmaVAWS-----DDRFGSA--EATVTVRKPLVVRPS 991
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 810 LPYAVRRGEKFALLVLVFNYMEKEQDVTVTLKYDkdsgyDLLKKDGTVVRRdevgqqnvriVSVAGGGtSKAVYFPIVPS 889
Cdd:COG2373 992 LPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEAS-----GGLTLEGEATQT----------VTLAAGG-RATVRFPLKAP 1055
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 890 SIGEIPVHISAIASQGGDAVEMNLRVDPQGYKVDRNIPFVIDlNNNSSDFSKNLeliwPNDVVDGSQKARLDVIGDMMGP 969
Cdd:COG2373 1056 DAGDAKVTVTATGGGESDAREVELPVRPANPLVTRATSGVLA-PGESWTLPLDL----PGGLRPGTGSLTLSLSSSPPLD 1130
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 970 VLNNAHKLVQMPYGCGEQNMLNLVPNILVVKYLRATNRNESQLEtKAIKFIEQGIQRELTYKRADNSFSAFGDSDKAgST 1049
Cdd:COG2373 1131 LAGLLRYLLRYPYGCTEQTTSRALPLLYLSDLAEALGLKGDKDA-ELRARIQAAIARLLSMQNSDGGFGLWPGGSES-DP 1208
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1050 WLTAFVVRSFHHAKQYAF-VDPNVISRAVAFLNSQqmesgaFAERGEVHHKDMQGGAQdggVALTAFVLisilengMENG 1128
Cdd:COG2373 1209 WLTAYATDFLLEAREAGYaVPDDALDRALDYLRNY------LRNPWEIEYDDAYRLAV---RAYALYVL-------ARAG 1272
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1129 KAVT-----YLEKHLDEVSGNAYTMAVVAYALqLAKSKQAGKAFENLKKHKIVEKSGDvkfasaqkkveklkESRAYMFQ 1203
Cdd:COG2373 1273 KADLgdlryLYDRRKDALSPLAKAQLAAALAL-LGDKARAEELLAAALARLRETGARD--------------YWYGDYGS 1337
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1204 arpvDIETTSYAVLSYLAQNQTSESLS-IIRWLVSQRNElGGFTSTQDTVMALQALSSYAAvTYSDKHTSQVTI-LNGKh 1281
Cdd:COG2373 1338 ----PLRDQALALALLAELGPDAPLAPkLARWLAKALKS-GRWLSTQETAWALLALAAYAR-AAGASPDFTATLtLDGK- 1410
|
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|....
gi 1972236247 1282 thSFDINIRNAIVLQSYQLSSLNDA-VSINANGTGVVFAQLSYSYYRDSLNDDA 1334
Cdd:COG2373 1411 --TLPLTGRGPLARVTLPAAELLAGpLTITNTGDGPLYYTLTLSGYPAEGPPPA 1462
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
750-840 |
2.42e-31 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 118.46 E-value: 2.42e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 750 TWIWSDLNST-SGEVEMEIEAPDTITSWVASTFAINEENGLGVAPTTSkLRVFRPFFIQLNLPYAVRRGEKFALLVLVFN 828
Cdd:pfam00207 1 TWLWDPVLVTdNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPE-LVVFKPFFVDLNLPYSVRRGEQFELKATVFN 79
|
90
....*....|..
gi 1972236247 829 YMEKEQDVTVTL 840
Cdd:pfam00207 80 YLDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1363-1454 |
1.44e-20 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 87.63 E-value: 1.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1363 GKSNMALAEIDALSGYRFDAEQVHTLTSIEDLQRVEMEkDDTKMNVYFNPLGGRPVCLSLYSDVTYQVADQKPANFRLVD 1442
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETV-DDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYD 79
|
90
....*....|..
gi 1972236247 1443 YYDPEEQLKMTY 1454
Cdd:pfam07677 80 YYEPERRATTFY 91
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
970-1261 |
1.18e-134 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 416.98 E-value: 1.18e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 970 VLNNAHKLVQMPYGCGEQNMLNLVPNILVVKYLRATNRNESQLETKAIKFIEQGIQRELTYKRADNSFSAFGDSDKAGST 1049
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1050 WLTAFVVRSFHHAKQYAFVDPNVISRAVAFLNSQQMESGAFAERGEVHHKDMQGGaQDGGVALTAFVLISILENGMENG- 1128
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGG-VDDEVALTAYVLIALLEAGLPSEr 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1129 ----KAVTYLEKHLDEVSgNAYTMAVVAYALQLAKSKQAGKAFENLKKHKIVEKSGDVKfasaqKKVEKLKESRAYMFQA 1204
Cdd:cd02897 160 pvveKALSCLEAALDSIS-DPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHW-----SRPPPSEEGPSYYWQA 233
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1972236247 1205 RPVDIETTSYAVLSYLAQNQ--TSESLSIIRWLVSQRNELGGFTSTQDTVMALQALSSY 1261
Cdd:cd02897 234 PSAEVEMTAYALLALLSAGGedLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
962-1261 |
1.93e-102 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 330.03 E-value: 1.93e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 962 VIGDMMGPVL----NNAHKLVQMPYGCGEQNMLNLVPNILVVKYLRATNRNESQLETKAIKFIEQGIQRELTYKRADNSF 1037
Cdd:pfam07678 3 VVGDIMGPAIqvvpENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDGSY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1038 SAFGDSDkaGSTWLTAFVVRSFHHAKQYAFVDPNVISRAVAFLNSQQMESGAFAERGEVHHKDMQGGAqDGGVALTAFVL 1117
Cdd:pfam07678 83 SAFGHSP--GSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGV-DGEVSLTAYVT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1118 ISILENGMENG----------KAVTYLEKHLDEVSGNAYTMAVVAYALQLAKS-KQAGKAFENLkkHKIVEKSGDVKFAS 1186
Cdd:pfam07678 160 IALLEALDINGllqrvhpsirKALTYLEQAQLAGLTSPYTLAILAYALALAGSpETREELLKSL--DAMAREEGNSRYWE 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972236247 1187 AQKKVEKlKESRAYMFQARPVDIETTSYAVLSYLAQNQTSESLSIIRWLVSQRNELGGFTSTQDTVMALQALSSY 1261
Cdd:pfam07678 238 RDEKSDP-QGVPEYPPQAPSLEVETTAYALLAYLLLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
970-1261 |
8.13e-102 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 327.04 E-value: 8.13e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 970 VLNNAHKLVQMPYGCGEQNMLNLVPNILVVKYLRATNRNESQLETKAIKFIEQGIQRELTYKRADNSFSAFGDSDKaGST 1049
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDS-GST 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1050 WLTAFVVRSFHHAKQYAFVDPNVISRAVAFLNSQQMESGAFAERGEVHHKDMQGGaQDGGVALTAFVLISILENGMEN-- 1127
Cdd:cd02891 80 WLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGG-VDDSVSLTAYVLIALAEAGKACda 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1128 --GKAVTYLEKHLDEVSgNAYTMAVVAYALQLAKSK-QAGKAFENLKKHkiveksgdvkfaSAQKKVEKLKESRAYMFQA 1204
Cdd:cd02891 159 siEKALAYLETQLDGLL-DPYALAILAYALALAGDStRADEALKKLLEA------------AREKGGTAHWSLSWPGDYG 225
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1972236247 1205 RPVDIETTSYAVLSYLAQNQTSESLSIIRWLVSQRNELGGFTSTQDTVMALQALSSY 1261
Cdd:cd02891 226 SSLRVEATAYALLALLKLGDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
971-1261 |
1.08e-93 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 304.58 E-value: 1.08e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 971 LNNAHKLVQMPYGCGEQNMLNLVPNILVVKYLRATN---RNESQLETKAIKFIEQGIQRELTYKRADNSFSAFGDSdkAG 1047
Cdd:cd02896 2 PEGLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNqweKLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNR--PS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1048 STWLTAFVVRSFHHAKQYAFVDPNVISRAVAFLNSQQMESGAFAERGEVHHKDMQGGAQ--DGGVALTAFVLISILE--- 1122
Cdd:cd02896 80 STWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVEgsEGDVSLTAFVLIALQEars 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1123 -NGMENG-------KAVTYLEKHLDEVSgNAYTMAVVAYALQLAKSKQAGKAFENLKKHKIVEKSGDVKFASAQKKVekl 1194
Cdd:cd02896 160 iCPPEVQnldqsirKAISYLENQLPNLQ-RPYALAITAYALALADSPLSHAANRKLLSLAKRDGNGWYWWTIDSPYW--- 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1972236247 1195 kesraYMFQARPVDIETTSYAVLSYLAQNQTSESLSIIRWLVSQRNELGGFTSTQDTVMALQALSSY 1261
Cdd:cd02896 236 -----PVPGPSAITVETTAYALLALLKLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
139-1334 |
5.13e-73 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 270.03 E-value: 5.13e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 139 DQKALSVFIQTDRAIYRPASLVRYRAIVVKSDLKPYVG-NATIKIFDPSRNLISQTIGVTLDRGVYSGELQLAEETLLGD 217
Cdd:COG2373 365 PPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPAGlPLTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGT 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 218 WFIEVETSNGVQDKS-SFTVDTYVLPKFEVNIKTSS-FITINDDLSVFVDAKYTYGKGVAG---KAKVSLELPWHRWHAM 292
Cdd:COG2373 445 WRLELYVDPKPALGSkSFRVEEFKPPRFKVDLTLDKePLKPGDPVTVTVDARYLFGAPAAGlkvEGEVTLRPARTAFPGY 524
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 293 VPTIIDENGVKKEEELMVERTVKLNRQGEAAVVFSNDELKRHKLLHEwgggsIRIVASVTEDiT--EIERNATHQISTFR 370
Cdd:COG2373 525 PGYRFGDPDEEFEPEELDLGEGTLDADGKASLSLPLPDAPDAPGPLR-----ATVEASVFES-GgrPVTRSATVPVHPAD 598
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 371 EEV-----KLDVEKQGDTFKPGLtynVVV--ALKQMDDTPVKATLPKRVQVSTFYNYPYN--HDTSSLQEEK-ETKIVEV 440
Cdd:COG2373 599 FYVgirlpLFDGDPEGAPATFEV---VAVdpDGKPVAGKGLKVELYREEWRYVWYKSDDGgwRYESQEKEEPvAEGTLTT 675
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 441 DAHGTSVLTLQPPincTSA--RIEAHYDIGGKdnFTATPIYSSlYVEAAVSPTKSFLQLLADNEgAVDVGKSLSFSLKAT 518
Cdd:COG2373 676 GADGPASLSLTPV---EWGryRLEVKDPDGGL--ATSVRFYAG-GNASWGAERPDRLELSLDKE-SYKPGETAKLLIQSP 748
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 519 QP---LSTITyqvmsRSNIVVSQQMTVNSEHATISFPATANMAP---------------KSRLIVYAIieSSQEVLVDAL 580
Cdd:COG2373 749 FAgraLVTVE-----RDGVLETQWVDVKGGGTTVEIPVTEDWAPnayvsatlvrpgdstANDMPARAY--GVAPLPVDPP 821
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 581 DFKVegifqnQVALSIDKQaVEPGQNVKFKVTSD----KNSFVGLLVVDQSVLllktgnDITREKVeqdlenydsnnvgg 656
Cdd:COG2373 822 ARRL------KVELTAPEK-LRPGETLTVTVKVKgaagKAAEVTLAAVDEGIL------NLTGYKT-------------- 874
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 657 gfggPRPWEAIDRKKRSiwrpwwgigGSDAQSIFsnaglvvltDALLyrepqrEFMSVMMMDGAPGMAEAAfaappmgGS 736
Cdd:COG2373 875 ----PDPLDFFYGKRAL---------GVETRDLY---------GRLI------GAFGGAAGALRSGGDGAL-------GR 919
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 737 SPPPPTVRKFFPHTWIWS---DLNStSGEVEMEIEAPDTITSW----VASTfaineENGLGVAptTSKLRVFRPFFIQLN 809
Cdd:COG2373 920 GGNPKPPRKRFKPVALFSgpvKTDA-DGKATVSFDLPDFNGTLrvmaVAWS-----DDRFGSA--EATVTVRKPLVVRPS 991
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 810 LPYAVRRGEKFALLVLVFNYMEKEQDVTVTLKYDkdsgyDLLKKDGTVVRRdevgqqnvriVSVAGGGtSKAVYFPIVPS 889
Cdd:COG2373 992 LPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEAS-----GGLTLEGEATQT----------VTLAAGG-RATVRFPLKAP 1055
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 890 SIGEIPVHISAIASQGGDAVEMNLRVDPQGYKVDRNIPFVIDlNNNSSDFSKNLeliwPNDVVDGSQKARLDVIGDMMGP 969
Cdd:COG2373 1056 DAGDAKVTVTATGGGESDAREVELPVRPANPLVTRATSGVLA-PGESWTLPLDL----PGGLRPGTGSLTLSLSSSPPLD 1130
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 970 VLNNAHKLVQMPYGCGEQNMLNLVPNILVVKYLRATNRNESQLEtKAIKFIEQGIQRELTYKRADNSFSAFGDSDKAgST 1049
Cdd:COG2373 1131 LAGLLRYLLRYPYGCTEQTTSRALPLLYLSDLAEALGLKGDKDA-ELRARIQAAIARLLSMQNSDGGFGLWPGGSES-DP 1208
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1050 WLTAFVVRSFHHAKQYAF-VDPNVISRAVAFLNSQqmesgaFAERGEVHHKDMQGGAQdggVALTAFVLisilengMENG 1128
Cdd:COG2373 1209 WLTAYATDFLLEAREAGYaVPDDALDRALDYLRNY------LRNPWEIEYDDAYRLAV---RAYALYVL-------ARAG 1272
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1129 KAVT-----YLEKHLDEVSGNAYTMAVVAYALqLAKSKQAGKAFENLKKHKIVEKSGDvkfasaqkkveklkESRAYMFQ 1203
Cdd:COG2373 1273 KADLgdlryLYDRRKDALSPLAKAQLAAALAL-LGDKARAEELLAAALARLRETGARD--------------YWYGDYGS 1337
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1204 arpvDIETTSYAVLSYLAQNQTSESLS-IIRWLVSQRNElGGFTSTQDTVMALQALSSYAAvTYSDKHTSQVTI-LNGKh 1281
Cdd:COG2373 1338 ----PLRDQALALALLAELGPDAPLAPkLARWLAKALKS-GRWLSTQETAWALLALAAYAR-AAGASPDFTATLtLDGK- 1410
|
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|....
gi 1972236247 1282 thSFDINIRNAIVLQSYQLSSLNDA-VSINANGTGVVFAQLSYSYYRDSLNDDA 1334
Cdd:COG2373 1411 --TLPLTGRGPLARVTLPAAELLAGpLTITNTGDGPLYYTLTLSGYPAEGPPPA 1462
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
970-1261 |
7.88e-58 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 202.40 E-value: 7.88e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 970 VLNNAHKLVQMPYG--------CGEQNMLNLVPNILVVKYLRATNRnesqlETKAIKFIEQGIQRELTYKRADNSFSAFG 1041
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAATGI-----RDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1042 DSDkAGSTWLTAFVVRSFHHAKQYAFVDPNVISRAVAFLNSQQMESGAFAERGEVHHKDMQGgaqDGGVALTAFVLISIL 1121
Cdd:cd00688 76 GND-YPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHRIGGD---ESDVRLTAYALIALA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1122 ENG-----MENGKAVTYLEKHLDEVSG-------NAYTMAVVAYALQLAKS---KQAGKAFENLKKHKIVEKSGDVKFAS 1186
Cdd:cd00688 152 LLGkldpdPLIEKALDYLLSCQNYDGGfgpggesHGYGTACAAAALALLGDldsPDAKKALRWLLSRQRPDGGWGEGRDR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1187 AQKKVeklkesraymfqaRPVDIETTSYAVLSYLAQNQTSESLSIIRWLVSQRNELGGFTS-------TQDTVMALQALS 1259
Cdd:cd00688 232 TNKLS-------------DSCYTEWAAYALLALGKLGDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVFALLALS 298
|
..
gi 1972236247 1260 SY 1261
Cdd:cd00688 299 LY 300
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
750-840 |
2.42e-31 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 118.46 E-value: 2.42e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 750 TWIWSDLNST-SGEVEMEIEAPDTITSWVASTFAINEENGLGVAPTTSkLRVFRPFFIQLNLPYAVRRGEKFALLVLVFN 828
Cdd:pfam00207 1 TWLWDPVLVTdNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPE-LVVFKPFFVDLNLPYSVRRGEQFELKATVFN 79
|
90
....*....|..
gi 1972236247 829 YMEKEQDVTVTL 840
Cdd:pfam00207 80 YLDKCLKVRVRL 91
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
495-631 |
1.59e-26 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 106.28 E-value: 1.59e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 495 LQLLADNEgAVDVGKSLSFSLKATQ----PLSTITYQVMSRSNIVVSQQMTVNsehATISFPATANMAPKSRLIVYAIIE 570
Cdd:pfam07703 1 LHLSTDKT-EYKPGETATVTVKSPFdgtvERDGFTYLVLSKGQIVVVGRGGVT---TSFSLPVTAEMAPSARVVAYYVRV 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1972236247 571 --SSQEVLVDALDFKVEGIFQNQVALSIDKQAVEPGQNVKFKVTSDKNSFVGLLVVDQSVLLL 631
Cdd:pfam07703 77 dlSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1363-1454 |
1.44e-20 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 87.63 E-value: 1.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 1363 GKSNMALAEIDALSGYRFDAEQVHTLTSIEDLQRVEMEkDDTKMNVYFNPLGGRPVCLSLYSDVTYQVADQKPANFRLVD 1442
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETV-DDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYD 79
|
90
....*....|..
gi 1972236247 1443 YYDPEEQLKMTY 1454
Cdd:pfam07677 80 YYEPERRATTFY 91
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
239-284 |
2.15e-16 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 75.39 E-value: 2.15e-16
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1972236247 239 YVLPKFEVNIKTSSFITINDD-LSVFVDAKYTYGKGVAGKAKVSLEL 284
Cdd:pfam17791 2 YVLPKFEVKVEVPKFISVKDEeFQVTICAKYTYGKPVKGKAYVTLCL 48
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
144-236 |
1.83e-15 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 73.12 E-value: 1.83e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972236247 144 SVFIQTDRAIYRPASLVRYRAIVVKSDLKPYVG-NATIKIFDPSRNLISQTIGVTLDRGVYSGELQLAEETLLGDWFIEV 222
Cdd:pfam01835 1 RAFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGlPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVL 80
|
90
....*....|....*
gi 1972236247 223 ETSNGVQDKS-SFTV 236
Cdd:pfam01835 81 RDGAGGSLGSgSFRV 95
|
|
| |
