3'-5' exonuclease domain-containing protein [Caenorhabditis elegans]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Rnd super family | cl33845 | Ribonuclease D [Translation, ribosomal structure and biogenesis]; |
32-84 | 1.93e-07 | ||
Ribonuclease D [Translation, ribosomal structure and biogenesis]; The actual alignment was detected with superfamily member COG0349: Pssm-ID: 440118 [Multi-domain] Cd Length: 365 Bit Score: 47.56 E-value: 1.93e-07
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| Name | Accession | Description | Interval | E-value | ||
| Rnd | COG0349 | Ribonuclease D [Translation, ribosomal structure and biogenesis]; |
32-84 | 1.93e-07 | ||
Ribonuclease D [Translation, ribosomal structure and biogenesis]; Pssm-ID: 440118 [Multi-domain] Cd Length: 365 Bit Score: 47.56 E-value: 1.93e-07
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| DNA_pol_A_exo1 | pfam01612 | 3'-5' exonuclease; This domain is responsible for the 3'-5' exonuclease proofreading activity ... |
27-86 | 1.37e-06 | ||
3'-5' exonuclease; This domain is responsible for the 3'-5' exonuclease proofreading activity of E. coli DNA polymerase I (polI) and other enzymes, it catalyzes the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI it is also found in the Werner syndrome helicase (WRN), focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D). Werner syndrome is a human genetic disorder causing premature aging; the WRN protein has helicase activity in the 3'-5' direction. The FFA-1 protein is required for formation of a replication foci and also has helicase activity; it is a homolog of the WRN protein. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome. Pssm-ID: 396266 [Multi-domain] Cd Length: 173 Bit Score: 44.21 E-value: 1.37e-06
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| RNaseD_exo | cd06142 | DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Ribonuclease (RNase) D ... |
27-86 | 8.25e-05 | ||
DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Ribonuclease (RNase) D is a bacterial enzyme involved in the maturation of small stable RNAs and the 3' maturation of tRNA. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. In vivo, RNase D only becomes essential upon removal of other ribonucleases. Eukaryotic RNase D homologs include yeast Rrp6p, human PM/Scl-100, and the Drosophila melanogaster egalitarian protein. Pssm-ID: 176654 [Multi-domain] Cd Length: 178 Bit Score: 39.44 E-value: 8.25e-05
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| 35EXOc | smart00474 | 3'-5' exonuclease; 3\' -5' exonuclease proofreading domain present in DNA polymerase I, Werner ... |
26-87 | 4.96e-04 | ||
3'-5' exonuclease; 3\' -5' exonuclease proofreading domain present in DNA polymerase I, Werner syndrome helicase, RNase D and other enzymes Pssm-ID: 214681 [Multi-domain] Cd Length: 172 Bit Score: 37.34 E-value: 4.96e-04
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| Name | Accession | Description | Interval | E-value | ||
| Rnd | COG0349 | Ribonuclease D [Translation, ribosomal structure and biogenesis]; |
32-84 | 1.93e-07 | ||
Ribonuclease D [Translation, ribosomal structure and biogenesis]; Pssm-ID: 440118 [Multi-domain] Cd Length: 365 Bit Score: 47.56 E-value: 1.93e-07
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| DNA_pol_A_exo1 | pfam01612 | 3'-5' exonuclease; This domain is responsible for the 3'-5' exonuclease proofreading activity ... |
27-86 | 1.37e-06 | ||
3'-5' exonuclease; This domain is responsible for the 3'-5' exonuclease proofreading activity of E. coli DNA polymerase I (polI) and other enzymes, it catalyzes the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI it is also found in the Werner syndrome helicase (WRN), focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D). Werner syndrome is a human genetic disorder causing premature aging; the WRN protein has helicase activity in the 3'-5' direction. The FFA-1 protein is required for formation of a replication foci and also has helicase activity; it is a homolog of the WRN protein. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome. Pssm-ID: 396266 [Multi-domain] Cd Length: 173 Bit Score: 44.21 E-value: 1.37e-06
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| RNaseD_exo | cd06142 | DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Ribonuclease (RNase) D ... |
27-86 | 8.25e-05 | ||
DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Ribonuclease (RNase) D is a bacterial enzyme involved in the maturation of small stable RNAs and the 3' maturation of tRNA. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. In vivo, RNase D only becomes essential upon removal of other ribonucleases. Eukaryotic RNase D homologs include yeast Rrp6p, human PM/Scl-100, and the Drosophila melanogaster egalitarian protein. Pssm-ID: 176654 [Multi-domain] Cd Length: 178 Bit Score: 39.44 E-value: 8.25e-05
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| 35EXOc | smart00474 | 3'-5' exonuclease; 3\' -5' exonuclease proofreading domain present in DNA polymerase I, Werner ... |
26-87 | 4.96e-04 | ||
3'-5' exonuclease; 3\' -5' exonuclease proofreading domain present in DNA polymerase I, Werner syndrome helicase, RNase D and other enzymes Pssm-ID: 214681 [Multi-domain] Cd Length: 172 Bit Score: 37.34 E-value: 4.96e-04
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| mut-7_like_exo | cd06146 | DEDDy 3'-5' exonuclease domain of Caenorhabditis elegans mut-7 and similar proteins; The mut-7 ... |
14-74 | 1.04e-03 | ||
DEDDy 3'-5' exonuclease domain of Caenorhabditis elegans mut-7 and similar proteins; The mut-7 subfamily is composed of Caenorhabditis elegans mut-7 and similar proteins found in plants and metazoans. Mut-7 is implicated in posttranscriptional gene silencing. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs, termed ExoI, ExoII and ExoIII, with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. Pssm-ID: 176655 Cd Length: 193 Bit Score: 36.50 E-value: 1.04e-03
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| WRN_exo | cd06141 | DEDDy 3'-5' exonuclease domain of WRN and similar proteins; WRN is a unique RecQ DNA helicase ... |
24-74 | 9.68e-03 | ||
DEDDy 3'-5' exonuclease domain of WRN and similar proteins; WRN is a unique RecQ DNA helicase exhibiting an exonuclease activity. It contains a DEDDy-type DnaQ-like 3'-5' exonuclease domain possessing three conserved sequence motifs termed ExoI, ExoII and ExoIII, with a specific YX(3)D pattern at ExoIII. These motifs are clustered around the active site and contain four conserved acidic residues that serve as ligands for the two metal ions required for catalysis. Mutations in the WRN gene cause Werner syndrome, an autosomal recessive disorder associated with premature aging and increased susceptibility to cancer and type II diabetes. WRN interacts with key proteins involved in DNA replication, recombination, and repair. It is believed to maintain genomic stability and life span by participating in DNA processes. WRN is stimulated by Ku70/80, an important regulator of genomic stability. Pssm-ID: 176653 [Multi-domain] Cd Length: 170 Bit Score: 33.71 E-value: 9.68e-03
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