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Conserved domains on  [gi|1972267356|ref|NP_001379158|]
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BTB domain-containing protein [Caenorhabditis elegans]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 13033312)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and PHR (PAM, highwire, and RPM) domain-containing protein similar to Homo sapiens BTB/POZ domain-containing (BTBD) proteins, such as BTBD1, BTBD2, BTBD3 and BTBD6, which may function as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 167-297 5.95e-82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 253.13  E-value: 5.95e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 167 GWQADKKTLRERIEHMYCNETLADVFFVVGIDDSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNteeaLEIELPDVEPSA 246
Cdd:cd18281     1 NWQASKTTVKERFAFLFNNETLSDVHFIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTS----AEIELPDVEPAA 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1972267356 247 FLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18281    77 FLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
PHR pfam08005
PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire ...
 453-598 3.43e-73

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.


:

Pssm-ID: 462339  Cd Length: 150  Bit Score: 230.97  E-value: 3.43e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 453 SRFQRIENRWGFCGTS-DRIKFMVDRRIFVVGFGLYGAISGPHEYKTQIKIIH----CGTNKTLAEHDTSFVCDGNSRPC 527
Cdd:pfam08005   1 NRFQSTGGGWGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIDgerwESLGEVLGENDTTFSSDGSNDIF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972267356 528 RVCFKEPVEILPGITYIAAALIRGPDSYYGTKGLRRVsTHDSDVTFQFTYAAMNNNGTSVEDGQIPEIIYY 598
Cdd:pfam08005  81 RVLFDEPVEIEPNVKYTASAKIKGPSSYYGTNGLREV-TCDGGVTFQFSSSSLSNNGTSVNRGQIPELLYY 150
BACK_BTBD1_like cd18487
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and ...
 293-387 5.35e-57

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This subfamily includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


:

Pssm-ID: 350562  Cd Length: 95  Bit Score: 186.41  E-value: 5.35e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 293 LVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIREIFLFQAVLRWAKFEAER 372
Cdd:cd18487     1 LSSDNAFMLLTQARLFDEPQLASLCLETIDKNTAEALAAEGFTDIDLDTLCVVLERDTLGIRECKLFQAVLRWAEAECQR 80

                          90
                  ....*....|....*
gi 1972267356 373 RGMPANGDSRRAVLS 387
Cdd:cd18487    81 QGLSVTPENQRKVLG 95
 
Name Accession Description Interval E-value
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 167-297 5.95e-82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 253.13  E-value: 5.95e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 167 GWQADKKTLRERIEHMYCNETLADVFFVVGIDDSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNteeaLEIELPDVEPSA 246
Cdd:cd18281     1 NWQASKTTVKERFAFLFNNETLSDVHFIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTS----AEIELPDVEPAA 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1972267356 247 FLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18281    77 FLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
PHR pfam08005
PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire ...
 453-598 3.43e-73

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.


Pssm-ID: 462339  Cd Length: 150  Bit Score: 230.97  E-value: 3.43e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 453 SRFQRIENRWGFCGTS-DRIKFMVDRRIFVVGFGLYGAISGPHEYKTQIKIIH----CGTNKTLAEHDTSFVCDGNSRPC 527
Cdd:pfam08005   1 NRFQSTGGGWGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIDgerwESLGEVLGENDTTFSSDGSNDIF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972267356 528 RVCFKEPVEILPGITYIAAALIRGPDSYYGTKGLRRVsTHDSDVTFQFTYAAMNNNGTSVEDGQIPEIIYY 598
Cdd:pfam08005  81 RVLFDEPVEIEPNVKYTASAKIKGPSSYYGTNGLREV-TCDGGVTFQFSSSSLSNNGTSVNRGQIPELLYY 150
BACK_BTBD1_like cd18487
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and ...
 293-387 5.35e-57

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This subfamily includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350562  Cd Length: 95  Bit Score: 186.41  E-value: 5.35e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 293 LVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIREIFLFQAVLRWAKFEAER 372
Cdd:cd18487     1 LSSDNAFMLLTQARLFDEPQLASLCLETIDKNTAEALAAEGFTDIDLDTLCVVLERDTLGIRECKLFQAVLRWAEAECQR 80

                          90
                  ....*....|....*
gi 1972267356 373 RGMPANGDSRRAVLS 387
Cdd:cd18487    81 QGLSVTPENQRKVLG 95
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 180-293 7.41e-24

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 96.17  E-value: 7.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 180 EHMYCNETLADVFFVVGIddsrQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEealEIELPDVEPSAFLALLKFLYSDEV 259
Cdd:pfam00651   2 NELREQGELCDVTLVVGD----KEFRAHKAVLAACSPYFKALFSGQESESSVS---EITLDDVSPEDFEALLEFMYTGKL 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1972267356 260 kIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRL 293
Cdd:pfam00651  75 -ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 190-293 2.53e-18

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 80.43  E-value: 2.53e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356  190 DVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYSDEVKIEAESVMTT 269
Cdd:smart00225   1 DVTLVVG----GKKFHAHKAVLAAHSPYFKALFSSDFKESDKSE---IYLDDVSPEDFRALLNFLYTGKLDLPEENVEEL 73

                           90       100
                   ....*....|....*....|....
gi 1972267356  270 LYTAKKYAVPAMEKECVRFLKQRL 293
Cdd:smart00225  74 LELADYLQIPGLVELCEEFLLKLL 97
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 301-404 1.30e-17

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 78.54  E-value: 1.30e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356  301 MLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIR-EIFLFQAVLRWAKfeaerrgmpANG 379
Cdd:smart00875   4 IRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVK---------HDP 74

                           90       100
                   ....*....|....*....|....*
gi 1972267356  380 DSRRAVLSRSIPLIRFPLMKIDEFA 404
Cdd:smart00875  75 EKRREHLPELLEHVRLPLLSPDYLL 99
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 298-408 5.73e-13

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 65.26  E-value: 5.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 298 AFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRI-REIFLFQAVLRWAKFEAERrgmp 376
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVpSEEEVFEAVIRWVKHDVER---- 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1972267356 377 angdsRRAVLSRSIPLIRFPLMKIDEFALHVE 408
Cdd:pfam07707  77 -----RKKHLPELLSAVRLPLLSPQYLLNLVE 103
PHA03098 PHA03098
kelch-like protein; Provisional
 183-450 1.69e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 44.37  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 183 YCNETLadVFFVVGIddsrqRIPAHKFVLSIGSVVFDAMFNGGLTPKnteealEIELP-DVEpsAFLALLKFLYSDEVKI 261
Cdd:PHA03098    9 FCDESI--IIVNGGG-----IIKVHKIILSSSSEYFKKMFKNNFKEN------EINLNiDYD--SFNEVIKYIYTGKINI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 262 EAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDT 341
Cdd:PHA03098   74 TSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 342 LCEVLTRDGLRI-REIFLFQAVLRWAKFEAerrgmpangDSRRAVLSRSIPLIRFPLmkidefalhvepshiLSDREMNK 420
Cdd:PHA03098  154 LIKILSDDKLNVsSEDVVLEIIIKWLTSKK---------NNKYKDICLILKVLRITF---------------LSEEGIKK 209

                         250       260       270
                  ....*....|....*....|....*....|
gi 1972267356 421 IFKYLavSPPDRPVLVYSDRPRCQISSTEY 450
Cdd:PHA03098  210 LKRWK--LRIKKKKIVFNKRCIKIIYSKKY 237
 
Name Accession Description Interval E-value
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 167-297 5.95e-82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 253.13  E-value: 5.95e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 167 GWQADKKTLRERIEHMYCNETLADVFFVVGIDDSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNteeaLEIELPDVEPSA 246
Cdd:cd18281     1 NWQASKTTVKERFAFLFNNETLSDVHFIVGKGDNEQRIPAHKFVLSIGSAVFDAMFNGGMATTS----AEIELPDVEPAA 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1972267356 247 FLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18281    77 FLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
PHR pfam08005
PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire ...
 453-598 3.43e-73

PHR domain; This domain is called PHR as it was original found in the proteins PAM, highwire and RPM. This domain can be duplicated in the highwire, PFAM and PRM sequence. The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils.


Pssm-ID: 462339  Cd Length: 150  Bit Score: 230.97  E-value: 3.43e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 453 SRFQRIENRWGFCGTS-DRIKFMVDRRIFVVGFGLYGAISGPHEYKTQIKIIH----CGTNKTLAEHDTSFVCDGNSRPC 527
Cdd:pfam08005   1 NRFQSTGGGWGYSGGSpDAIRFSVDRDIFLVGFGLYGSIGGPADYSVKIELIDgerwESLGEVLGENDTTFSSDGSNDIF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972267356 528 RVCFKEPVEILPGITYIAAALIRGPDSYYGTKGLRRVsTHDSDVTFQFTYAAMNNNGTSVEDGQIPEIIYY 598
Cdd:pfam08005  81 RVLFDEPVEIEPNVKYTASAKIKGPSSYYGTNGLREV-TCDGGVTFQFSSSSLSNNGTSVNRGQIPELLYY 150
BACK_BTBD1_like cd18487
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and ...
 293-387 5.35e-57

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This subfamily includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350562  Cd Length: 95  Bit Score: 186.41  E-value: 5.35e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 293 LVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIREIFLFQAVLRWAKFEAER 372
Cdd:cd18487     1 LSSDNAFMLLTQARLFDEPQLASLCLETIDKNTAEALAAEGFTDIDLDTLCVVLERDTLGIRECKLFQAVLRWAEAECQR 80

                          90
                  ....*....|....*
gi 1972267356 373 RGMPANGDSRRAVLS 387
Cdd:cd18487    81 QGLSVTPENQRKVLG 95
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 168-297 2.14e-52

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 175.63  E-value: 2.14e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 168 WQADKKTLRERIEHMYCNETLADVFFVVGIDDSR------QRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEealeIELPD 241
Cdd:cd18346     2 WQATKSSLKERFAFLFNNELLSDVRFVVGKGRPRgpgpgaQRIPAHRFVLAAGSAVFDAMFNGGMATTSAE----IELPD 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1972267356 242 VEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18346    78 VEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 168-297 3.72e-51

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 172.18  E-value: 3.72e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 168 WQADKKTLRERIEHMYCNETLADVFFVVGIDDSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEealeIELPDVEPSAF 247
Cdd:cd18347     2 WQATKPTVQERFAFLFNNEVLSDVHFLVGKGLGSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE----IELPDVEPAAF 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1972267356 248 LALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18347    78 LALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 182-293 1.66e-44

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 153.71  E-value: 1.66e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 182 MYCNETLADVFFVVGIDDSRQRIPAHKFVLSIGSVVFDAMFNGGLTpkntEEALEIELPDVEPSAFLALLKFLYSDEVKI 261
Cdd:cd18282     1 MFNNELMADVHFIVGPPGGTQRIPAHKYVLATGSSVFYAMFYGGLA----ENKNEIEIPDVEPAAFLNLLRYLYCDEIDL 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1972267356 262 EAESVMTTLYTAKKYAVPAMEKECVRFLKQRL 293
Cdd:cd18282    77 EPDTVLATLYAAKKYLVPHLARACVQFLETSL 108
BACK_BTBD1 cd18522
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); ...
 293-398 1.88e-41

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein specifically expressed in skeletal muscle. It interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. It may serve as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350597  Cd Length: 107  Bit Score: 145.60  E-value: 1.88e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 293 LVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIREIFLFQAVLRWAKFEAER 372
Cdd:cd18522     1 LRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDLDTLCAVLERDTLSIRESRLFGAVVRWAEAECQR 80

                          90       100
                  ....*....|....*....|....*.
gi 1972267356 373 RGMPANGDSRRAVLSRSIPLIRFPLM 398
Cdd:cd18522    81 QQLPVTSENKQKVLGKALSLIRFPLM 106
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 182-293 6.44e-40

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 141.27  E-value: 6.44e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 182 MYCNETLADVFFVVGIDDSRQRIPAHKFVLSIGSVVFDAMFNGGLTpkntEEALEIELPDVEPSAFLALLKFLYSDEVKI 261
Cdd:cd18349     2 MFNNELMADVHFIVGPPGASQRVPAHKYVLAVGSSVFYAMFYGDLA----EVKSEIHIPDVEPAAFLILLKYMYSDEIDL 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1972267356 262 EAESVMTTLYTAKKYAVPAMEKECVRFLKQRL 293
Cdd:cd18349    78 EADTVLATLYAAKKYIVPALAKACVNFLETSL 109
BACK_BTBD2 cd18523
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); ...
 293-398 6.42e-39

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350598  Cd Length: 106  Bit Score: 138.58  E-value: 6.42e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 293 LVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIREIFLFQAVLRWAKFEAER 372
Cdd:cd18523     1 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWAEAECQR 80

                          90       100
                  ....*....|....*....|....*.
gi 1972267356 373 RGMPANGDSRRAVLSRSIPLIRFPLM 398
Cdd:cd18523    81 QQLQVTPENKRKVLGKALSLIRFPLM 106
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 168-302 9.58e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 133.22  E-value: 9.58e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 168 WQADKKTLRERIEHMYCNETLADVFFVVGIDDSRQRIPAHKFVLSIGSVVFDAMFNGGLTpkntEEALEIELPDVEPSAF 247
Cdd:cd18348     1 WQGLYPTIRERNAVMFNNDLMADIHFVVGPPGGTQRLPGHKYVLAVGSSVFHAMFYGELA----EDKDEIRIPDVEPAAF 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1972267356 248 LALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDNAFMML 302
Cdd:cd18348    77 LAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 131
BACK_BTBD3_like cd18488
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and ...
 297-386 5.48e-34

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350563  Cd Length: 95  Bit Score: 124.40  E-value: 5.48e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 297 NAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIREIFLFQAVLRWAKFEAERRGMP 376
Cdd:cd18488     5 NACVLLSQSRLFEEPELMQRCWEVIDAQAELALKSEGFTEIDYKTLESILRRETLNAKESVVFEAALRWAEAECQRRGLE 84

                          90
                  ....*....|
gi 1972267356 377 ANGDSRRAVL 386
Cdd:cd18488    85 PTPENKRKVL 94
BACK_BTBD6 cd18525
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); ...
 297-386 4.03e-27

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also called lens BTB domain protein, is a BTB-domain-containing Kelch-like protein that is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350600  Cd Length: 95  Bit Score: 105.17  E-value: 4.03e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 297 NAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIREIFLFQAVLRWAKFEAERRGMP 376
Cdd:cd18525     5 NACVLLSQSRLFEEPELTQRCWEVIDAQAELALKSEGFCEIDQQTLEIILTRETLNTKEVVVFEAVLNWAEAECKRQGLP 84

                          90
                  ....*....|
gi 1972267356 377 ANGDSRRAVL 386
Cdd:cd18525    85 PTARNKRNVL 94
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 180-293 7.41e-24

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 96.17  E-value: 7.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 180 EHMYCNETLADVFFVVGIddsrQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEealEIELPDVEPSAFLALLKFLYSDEV 259
Cdd:pfam00651   2 NELREQGELCDVTLVVGD----KEFRAHKAVLAACSPYFKALFSGQESESSVS---EITLDDVSPEDFEALLEFMYTGKL 74

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1972267356 260 kIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRL 293
Cdd:pfam00651  75 -ISEENVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK_BTBD3 cd18524
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); ...
 293-386 4.00e-23

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in mammalian neocortex.


Pssm-ID: 350599  Cd Length: 95  Bit Score: 94.02  E-value: 4.00e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 293 LVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIREIFLFQAVLRWAKFEAER 372
Cdd:cd18524     1 LSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAEVECQR 80

                          90
                  ....*....|....
gi 1972267356 373 RGMPANGDSRRAVL 386
Cdd:cd18524    81 QELQPTIENKRKVL 94
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 188-276 4.28e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 87.61  E-value: 4.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 188 LADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYSDEVKIEAESVM 267
Cdd:cd18186     1 LCDVTLVVG----GREFPAHRAVLAARSPYFRAMFSSGMKESSSSE---IELDDVSPEAFEALLDYIYTGELELSEENVE 73


                  ....*....
gi 1972267356 268 TTLYTAKKY 276
Cdd:cd18186    74 ELLAAADKL 82
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 190-293 2.53e-18

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 80.43  E-value: 2.53e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356  190 DVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYSDEVKIEAESVMTT 269
Cdd:smart00225   1 DVTLVVG----GKKFHAHKAVLAAHSPYFKALFSSDFKESDKSE---IYLDDVSPEDFRALLNFLYTGKLDLPEENVEEL 73

                           90       100
                   ....*....|....*....|....
gi 1972267356  270 LYTAKKYAVPAMEKECVRFLKQRL 293
Cdd:smart00225  74 LELADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 177-289 4.59e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 79.98  E-value: 4.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 177 ERIEHMYCNETLADVFFVVGidDSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEALEIElpDVEPSAFLALLKFLYS 256
Cdd:cd18294     3 ADMKSLINNPEFSDVKFLVG--PERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVLS--DIEPEVFRAVLEFIYT 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1972267356 257 DEVKIEAESVMTTLYTAKKYAVPAMEKECVRFL 289
Cdd:cd18294    79 NCVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 188-297 5.08e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 79.72  E-value: 5.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 188 LADVFFVVGIddsrQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYSDEVKIEAESVM 267
Cdd:cd18234     1 LCDVILIAGD----RRIPAHRLVLSAVSDYFAAMFTNDVREATEEE---IKLKDVDPDALWTLVQYCYTGRLELKEDNVE 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 1972267356 268 TTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18234    74 SLLATACLLQLSEVVEACCGFLMKQLHPSN 103
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 179-298 8.90e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 79.64  E-value: 8.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 179 IEHMYCNETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTpknteEALE--IELPDVEPSAFLALLKFLYS 256
Cdd:cd18238     6 LHQFYENGELCDVTLKVG----EKSIHCHRLVLACVSPYFRAMFTSEMA-----ESKQdsITIKDIDEEAVELLVDFAYT 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1972267356 257 DEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDNA 298
Cdd:cd18238    77 GKLTLTVDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNC 118
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 301-404 1.30e-17

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 78.54  E-value: 1.30e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356  301 MLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIR-EIFLFQAVLRWAKfeaerrgmpANG 379
Cdd:smart00875   4 IRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVK---------HDP 74

                           90       100
                   ....*....|....*....|....*
gi 1972267356  380 DSRRAVLSRSIPLIRFPLMKIDEFA 404
Cdd:smart00875  75 EKRREHLPELLEHVRLPLLSPDYLL 99
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 182-297 1.14e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 76.37  E-value: 1.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 182 MYCNETLADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYSDEVKI 261
Cdd:cd18237    15 MRKQKTLCDVILIV----EGREIKAHRVVLAAASHFFHLMFTSNMTESKSSE---VELKDAEPDIIELLVEFAYTARISV 87

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1972267356 262 EAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18237    88 NSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASN 123
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 175-289 1.84e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 75.74  E-value: 1.84e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 175 LRERIEHMYCNETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEealEIELPDVEPSAFLALLKFL 254
Cdd:cd18287     9 LSEDIGALFLNEEYSDVTFVVE----EKRFPAHRVILAARSEYFRALLYGGMRESQQS---EIELKDTNAEAFKALLKYI 81

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1972267356 255 YSDEV---KIEAESVMTTLYTAKKYAVPAMEKECVRFL 289
Cdd:cd18287    82 YTGRLtltDLKEDVLLDVLGLAHQYGFEELEAAISDYL 119
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 185-293 3.73e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 69.33  E-value: 3.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 185 NETLADVFFVVGIDDSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEealEIELPDVEPSAFLALLKFLYSDEVKIEAE 264
Cdd:cd18248    18 SQQLCDVTLKVKYQDPKEEFMAHKVVLASSSPYFKAMFTSGLRECGME---VVPIEGVHPCVMSRLIEFAYTASISVGEK 94

                          90       100
                  ....*....|....*....|....*....
gi 1972267356 265 SVMTTLYTAKKYAVPAMEKECVRFLKQRL 293
Cdd:cd18248    95 CVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 177-288 6.24e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 68.47  E-value: 6.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 177 ERIEHMYCNETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMfnggLTPKNTEEAL--EIELpdVEPSA----FLAL 250
Cdd:cd18292     6 QDIAQLYNNEELSDIVLRVG----GKVFHAHRLILAKSSDVFRVM----LSNDWWSESKqsEIEL--VEDPEcaavFEKF 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1972267356 251 LKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRF 288
Cdd:cd18292    76 LRYLYTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 183-285 6.64e-14

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 67.75  E-value: 6.64e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 183 YCNETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYSDEVKIE 262
Cdd:cd18314     1 YNDSEFSDVVLCVG----DRKFFAHRIVLCARSPVFRSMLTGSMIESNLKE---VTLEDVEPEIFETVLKYMYTGQVTLS 73

                          90       100
                  ....*....|....*....|...
gi 1972267356 263 AESVMTTLYTAKKYAVPAMEKEC 285
Cdd:cd18314    74 EENVLDLLMLASKYQVPDLEKLC 96
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 296-402 1.29e-13

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 66.87  E-value: 1.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 296 DNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIREIFLFQAVLRWAKFEaerrgm 375
Cdd:cd14822     4 RNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWCEHN------ 77

                          90       100
                  ....*....|....*....|....*..
gi 1972267356 376 PANGDSRRAVLSrsipLIRFPLMKIDE 402
Cdd:cd14822    78 PDSKEDAKEILE----AVRLPLMSLTE 100
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 298-408 5.73e-13

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 65.26  E-value: 5.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 298 AFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRI-REIFLFQAVLRWAKFEAERrgmp 376
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVpSEEEVFEAVIRWVKHDVER---- 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1972267356 377 angdsRRAVLSRSIPLIRFPLMKIDEFALHVE 408
Cdd:pfam07707  77 -----RKKHLPELLSAVRLPLLSPQYLLNLVE 103
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 185-297 1.14e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 65.62  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 185 NETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGgltpkNTEEAL--EIELPDVEPSAFLALLKFLYSDEVKIE 262
Cdd:cd18259    29 NPKLSDVTLLVG----GREFPCHRSVLALCSHYFNAMFTG-----DFVESIsaRVEIKDVDPAVMESLIDFAYTGKLTIN 99

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1972267356 263 AESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18259   100 QGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATN 134
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 185-297 1.81e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 64.39  E-value: 1.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 185 NETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKnteEALEIELPDVEPSAFLALLKFLYSDEVKIEAE 264
Cdd:cd18242    18 SNTLCDVTLRVE----GKEFPAHRIVLAACSDYFCAMFTSEMSEK---GKSEVELQGLTASTMEILLDFVYTETVHVTVE 90

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1972267356 265 SVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18242    91 NVQELLPAACLLQLKGVKQACCEFLESQLDPSN 123
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 180-279 2.23e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 63.80  E-value: 2.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 180 EHMYCNETLADVFFVVgiDDsrQRIPAHKFVLSIGSVVFDAMFNGGLTpknTEEALEIELPDVEPSAFLALLKFLYSDEV 259
Cdd:cd18300     1 KLFLNKGLFSDVTFIV--ED--GTIPAHKALLVARCDVMAAMFGGNFR---ESSAKEVELPGVSKETFLALLEYLYTDQA 73

                          90       100
                  ....*....|....*....|.
gi 1972267356 260 KI-EAESVMTTLYTAKKYAVP 279
Cdd:cd18300    74 PIlEDGDCVGLIVLANRLCLP 94
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 176-298 3.22e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 63.58  E-value: 3.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 176 RERIEHMYCnetlaDVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLY 255
Cdd:cd18256    13 KLRGQHEFC-----DVQLQVG----MELFSVHRLVLAASSPYFAALFAGGMSESSKDV---VQIHGVEPDIFHILLDFIY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1972267356 256 SDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDNA 298
Cdd:cd18256    81 TGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNC 123
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 185-293 3.64e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 63.47  E-value: 3.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 185 NETLADVFFVVGIddsrQRIPAHKFVLSIGSVVFDAMFNGGL--TPKNTEEALEIELPDVEPSAFLALLKFLYSDEVKIE 262
Cdd:cd18296    14 ELSFPDVCFQVEG----HRFPCHKAFFCGRSDYFKALLRDHFaeSEENNGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLP 89

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1972267356 263 AESVMTTLYTAKKYAVPAMEKECVRFLKQRL 293
Cdd:cd18296    90 PENAYDVLYVADMYLLPGLKRLCGTVLAQSL 120
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 185-297 4.21e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 63.06  E-value: 4.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 185 NETLADVFFVVGIddsrQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEealEIELPDVEPSAFLALLKFLYS---DEVKI 261
Cdd:cd18297     9 NPEMSDVTFLVEG----RPFYAHKIVLVTASDRFKSMLSSGSTEAQTP---VIEIPDIRYDIFQLMMQYLYTggvESLDV 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1972267356 262 EAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18297    82 AQDDALELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 181-295 9.46e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 62.45  E-value: 9.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 181 HMYCNETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYSDEVK 260
Cdd:cd18235    14 ELRKQNLLCDVILVAD----GVEIPAHRVVLASCSPYFHAMFTGDLSESRANR---VTLQDVDGKALLLLIDYVYTAEIQ 86

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1972267356 261 IEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVP 295
Cdd:cd18235    87 VTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 187-297 1.13e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 62.48  E-value: 1.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 187 TLADVFFVVGIDDsrqrIPAHKFVLSIGSVVFDAMFNGGLtpKNTEEALeIELPDVEPSAFLALLKFLYSDEVKIEAESV 266
Cdd:cd18265    22 TFTDVVLLVDGKD----FPCHRATLSANSAYFRAMFGGHL--KESRQAV-VEIQKVSAAAMEVLLDYMYGGGLRIQEDNV 94

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1972267356 267 MTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18265    95 ESVLEASDLLQVSKLREACVRFLEGQLHPCN 125
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 205-297 1.17e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 62.42  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 205 PAHKFVLSIGSVVFDAMFnggLTPKNTEEALEIELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKE 284
Cdd:cd18269    40 PCHRLVLAACSPYFRAMF---LSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRFQIPSIFTV 116

                          90
                  ....*....|...
gi 1972267356 285 CVRFLKQRLVPDN 297
Cdd:cd18269   117 CVSYLQKRLSLSN 129
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 188-297 1.31e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 61.96  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 188 LADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTpkNTEEAlEIELPDVEPSAFLALLKFLYSDEVKIEAESVM 267
Cdd:cd18240    17 LCDVVIRVN----GVEFPAHRNILCACSPYFRALFTNGWN--ETEKK-VYKIPGVSPEMMELIIEYAYTRTVPITAENVE 89

                          90       100       110
                  ....*....|....*....|....*....|
gi 1972267356 268 TTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18240    90 ELLPAADQFNIMGIVKACCDFLEDQLCPEN 119
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 182-297 1.48e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 61.57  E-value: 1.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 182 MYCNETLADVffVVGIDDsrQRIPAHKFVLSIGSVVFDamfnggltPKNTEEALEIELPDVEPSAFLALLKFLYSDEV-- 259
Cdd:cd18303    12 LFDKELYSDI--TIKLAD--KSIPAHKFVLAARSEKWS--------NENLASTNELDLSDISYEVVLALLRWLYTDELdl 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1972267356 260 KIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18303    80 TLDDEFLLELMKAAKRFQLTDLVERCERALMSSVNVDN 117
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 192-298 1.66e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 61.71  E-value: 1.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 192 FFVVGIDDSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLY 271
Cdd:cd18250    21 FFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADR---VVLHGVSAEILGLLLDFSYTGRVTVTQDNVEALLR 97

                          90       100
                  ....*....|....*....|....*..
gi 1972267356 272 TAKKYAVPAMEKECVRFLKQRLVPDNA 298
Cdd:cd18250    98 AADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 189-258 3.75e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 60.42  E-value: 3.75e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 189 ADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEealEIELPDVEPSAFLALLKFLYSDE 258
Cdd:cd18280    15 ADVTFNV----DGEKFRAHKLVLAARSPVFRSMLFGPMREENEG---EIVIEDVEPPVFKALLHFIYKDE 77
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 205-297 3.83e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 61.00  E-value: 3.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 205 PAHKFVLSIGSVVFDAMFNGGLTPkntEEALEIELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKE 284
Cdd:cd18340    40 PCHRLVLAACSPYFRAMFLSDLEE---SKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTV 116

                          90
                  ....*....|...
gi 1972267356 285 CVRFLKQRLVPDN 297
Cdd:cd18340   117 CVSFLQKRLCLSN 129
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 186-295 5.44e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 60.25  E-value: 5.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 186 ETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYSDEVKIEAES 265
Cdd:cd18257    16 HELCDVVLRVG----DVKIHAHKVVLASCSPYFKAMFTGNLSEKENSE---VEFQCIDETALQAIVEYAYTGTVFISQAT 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 1972267356 266 VMTTLYTAKKYAVPAMEKECVRFLKQRLVP 295
Cdd:cd18257    89 VESLLPAANLLQIKLVLKECCDFLESQLDP 118
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 185-297 1.01e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 59.41  E-value: 1.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 185 NETLADVFFVVgidDSRqRIPAHKFVLSIGSVVFDAMFNGGLTPKnteEALEIELPDVEPSAFLALLKFLYSDEVKIEAE 264
Cdd:cd18352    10 NATLSDVTFLV---EGR-RFYAHRIALLASSDAFRAMFDGGYREK---EARDIEIPNIRWEVFELMMRFIYTGSVDITND 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1972267356 265 SVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18352    83 IAKDLLRAADQYLLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 172-297 1.41e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 59.29  E-value: 1.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 172 KKTLReRIEHMYCNETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEealEIELPDVEPSAFLALL 251
Cdd:cd18336     4 EQTFR-KMENYLQHKQLCDVLLIAG----NLKIPAHRLVLSAVSDYFAAMFTNDVREAKQE---EIKMEGVDPDALKALV 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1972267356 252 KFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18336    76 HYAYTGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSN 121
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 204-297 1.41e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 59.47  E-value: 1.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 204 IPAHKFVLSIGSVVFDAMFnggLTPKNTEEALEIELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEK 283
Cdd:cd18341    39 LPCHRLILAACSPYFREYF---LSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFT 115

                          90
                  ....*....|....
gi 1972267356 284 ECVRFLKQRLVPDN 297
Cdd:cd18341   116 VCVTYLQKRLSPAN 129
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 188-292 2.76e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 58.06  E-value: 2.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 188 LADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYSDEVKIEAESVM 267
Cdd:cd18247    19 LCDVTLKVG----DQKFSAHRIVLAATIPYFHAMFTHDMVESKQDE---ITMQGIEPSALEALINFAYSGRIAIDTSNVQ 91

                          90       100
                  ....*....|....*....|....*
gi 1972267356 268 TTLYTAKKYAVPAMEKECVRFLKQR 292
Cdd:cd18247    92 SLLVGASFLQLQSVKDACCEFLKER 116
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 295-348 8.42e-10

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 54.59  E-value: 8.42e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1972267356 295 PDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTR 348
Cdd:cd14733     2 PENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 177-297 1.10e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 56.61  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 177 ERIEHMYCNETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYS 256
Cdd:cd18337    12 KKMENYLRHKQLCDVVLVAG----DRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEE---IKMEGVEPNALWALVQYAYT 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1972267356 257 DEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18337    85 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 125
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 181-288 1.66e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 55.73  E-value: 1.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 181 HMYCNETLADVFFVVgiDDsrQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEealEIELPDVEPSAFLALLKFLYSDEVK 260
Cdd:cd18286    10 QLFLNGEDSDITIKV--DG--KTFKAHRCILCARSSYFAAMLSGSWAESNSS---EITLTGVSHAAVSFVLLFIYGGVLD 82

                          90       100
                  ....*....|....*....|....*....
gi 1972267356 261 I-EAESVMTTLYTAKKYAVPAMeKECVRF 288
Cdd:cd18286    83 LpDDVNLGELLSLADMYGLDGL-KDVVAY 110
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 181-290 2.63e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 54.91  E-value: 2.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 181 HMYCNETLADVFFVVgidDSRQRIPAHKFVLSIGSVVFDAMFnggltpkNTEEALEIElPDVEPSAFLALLKFLYSDEVK 260
Cdd:cd18299     5 NLLHSPSCADVVFIL---QGGVRIFAHRIVLAAASSVFADLF-------LMMTVVTLD-SDITPEAFRRVLEFLYTGVLD 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 1972267356 261 IEAESVMTTLYTAKKYAVPAMEKECVRFLK 290
Cdd:cd18299    74 ENEDDLKELKDAAELLELFDLVMMCTNVLN 103
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 185-297 3.27e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 55.23  E-value: 3.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 185 NETLADVFFVVGiddSRQrIPAHKFVLSIGSVVFDAMFNGGLtpKNTEEALeIELPDVEPSAFLALLKFLYSDEVKIEAE 264
Cdd:cd18253    15 SRLFTDVIICVE---GRE-FPCHRAILSACSSYFRAMFCNDH--RESREML-VEINGILAEAMDCFLQYVYTGKVKITTE 87

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1972267356 265 SVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18253    88 NVQYLFETSSLFQISPLRDACAKFLEEQLDPCN 120
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 185-298 5.03e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 54.57  E-value: 5.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 185 NETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNteeALEIELPDVEPSAFLALLKFLYSDEVKIEAE 264
Cdd:cd18306    15 NRQFCDVILQVG----GHEIPAHRAVLACASPYLFELFSSDSDGES---ILTVKLDGLDPDAVEVLVNYAYTSRLEVPAD 87

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1972267356 265 SVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDNA 298
Cdd:cd18306    88 LVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNC 121
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 188-264 5.98e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 53.32  E-value: 5.98e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1972267356 188 LADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFngglTPKNTEEALEIELPDVEPSAFLALLKFLYSDEVKIEAE 264
Cdd:cd18315     1 LVDVTLACE----GGSLKAHKLVLAAASPYFAALL----KETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQE 69
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 177-298 8.54e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 54.22  E-value: 8.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 177 ERIEHMYCNETLADVffVVGIDDSRQrIPAHKFVLSIGSVVFDAMFNGGLTpKNTEEalEIELPDVEPSAFLALLKFLYS 256
Cdd:cd18274    11 QQLKAMYDEGQLTDI--VVEVDHGKT-FSCHRNVLAAISPYFRSMFTSGLT-ESTQK--EVRIVGVEAESMHLVLDYAYT 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1972267356 257 DEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDNA 298
Cdd:cd18274    85 SRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNS 126
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 172-297 1.11e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 53.90  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 172 KKTLReRIEHMYCNETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALL 251
Cdd:cd18335     4 EQTFR-KMESYLKQQQLCDVILIAG----NRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEE---IKMEGIDPNALWDLV 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1972267356 252 KFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18335    76 QFAYTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSN 121
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 296-366 1.71e-08

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 51.54  E-value: 1.71e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972267356 296 DNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIREIFLFQAVLRWA 366
Cdd:cd18494     3 ETACEALQAAVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREWA 73
BACK_GPRS_like cd18507
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched ...
 296-367 1.72e-08

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.


Pssm-ID: 350582  Cd Length: 80  Bit Score: 51.74  E-value: 1.72e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972267356 296 DNAFMMLSQAKLFDEPD----LMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIREIFLFQAVLRWAK 367
Cdd:cd18507     3 DTVCALLASAERYDQYKctktLVQKVLEFVDKHGTDVLNLPEFLLLPEHVVRLILSRDSLGADEMTKFQAALAWSR 78
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 177-297 4.21e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 52.07  E-value: 4.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 177 ERIEHMYCNETLADVFFVVGIddsrQRIPAHKFVLSIGSVVFDAMFNGGLTpknTEEALEIELPDVEPSAFLALLKFLYS 256
Cdd:cd18249    12 EAINLLRKHRELCDVVLVVGA----KKIYAHRVILSACSPYFRAMFTGELA---ESRQTEVTIRDIDERAMELLIDFAYT 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1972267356 257 DEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18249    85 SQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSN 125
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 302-365 6.80e-08

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 49.88  E-value: 6.80e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972267356 302 LSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIR-EIFLFQAVLRW 365
Cdd:cd18493     9 LQYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEdEYTLFQAVEKW 73
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 187-295 8.87e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 50.88  E-value: 8.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 187 TLADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGGLTpknTEEALEIELPDVEPSAFLALLKFLYSDEVKIEAESV 266
Cdd:cd18339    20 LLCDVTIVA----EDVEIEAHRVVLAACSPYFCAMFTGDMS---ESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENV 92

                          90       100
                  ....*....|....*....|....*....
gi 1972267356 267 MTTLYTAKKYAVPAMEKECVRFLKQRLVP 295
Cdd:cd18339    93 QVLLPAASLLQLMDVRQNCCDFLQSQLHP 121
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 204-295 1.95e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 50.07  E-value: 1.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 204 IPAHKFVLSIGSVVFDAMFNGGLTpknTEEALEIELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEK 283
Cdd:cd18338    33 IAAHRVVLAACSPYFHAMFTGEMS---ESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKK 109

                          90
                  ....*....|..
gi 1972267356 284 ECVRFLKQRLVP 295
Cdd:cd18338   110 TCCEFLESQLHP 121
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 207-289 2.52e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 50.28  E-value: 2.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 207 HKFVLSIGSVVFDAMFNggltpKNTEEALE--IELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKE 284
Cdd:cd18272    47 HRLVLSAQSCFFRSMFT-----SNLKEARNrvIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADMYQLTALFEE 121


                  ....*
gi 1972267356 285 CVRFL 289
Cdd:cd18272   122 CSRFL 126
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 182-302 3.79e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 49.82  E-value: 3.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 182 MYCNETLADVFFVVGIDDSR----QRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYSD 257
Cdd:cd18273    20 FYDARLLTDVTIEVNGPGSGpgsgRLFPCNRNVLAAASPYFKSMFTGGLYESKQET---VTIHDVDSESMALIIDYCYTG 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1972267356 258 EVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDNAFMML 302
Cdd:cd18273    97 RVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 319-374 5.76e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 48.08  E-value: 5.76e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1972267356 319 EVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIR-EIFLFQAVLRWAKFEAERRG 374
Cdd:cd18455    26 EYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGnEEYIFEAVLRWVRHDPEERK 82
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 188-297 6.21e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 48.54  E-value: 6.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 188 LADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEealEIELPDVEPSAFLALLKFLYSDEVKIEAESVM 267
Cdd:cd18255    18 LLDVTLIA----DGQRFQAHKVVLASCSDYFRAMFTGGMRESSQD---EIELKGVSAKGLKHILDFAYTSELTLDLDCIQ 90

                          90       100       110
                  ....*....|....*....|....*....|
gi 1972267356 268 TTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18255    91 DVLGAAVHLQMLPVVELCEEFLKSAMSVEN 120
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 205-301 6.62e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 49.22  E-value: 6.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 205 PAHKFVLSIGSVVFDAMFNGGLtpkNTEEALEIELPD-VEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEK 283
Cdd:cd18267    53 PCHRAVLAACSRYFEAMFSGGL---KESQDSEVNFHDsIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRD 129

                          90
                  ....*....|....*...
gi 1972267356 284 ECVRFLKQRLVPDNAFMM 301
Cdd:cd18267   130 ACAEFLEKNLHPTNCLGM 147
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 175-297 1.17e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 47.91  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 175 LRERIEHMYCNETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNggltpKNTEEALE--IELPDVEPSAFLALLK 252
Cdd:cd18279     5 LAEDLGNLWENSRFTDCCLCVG----GQEFQAHKAILAARSPVFSAMFE-----HEMEESKKnrVEINDVDPEVFKEMMR 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1972267356 253 FLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18279    76 FIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 180-297 1.31e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 47.88  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 180 EHMYCNETLADVFFVVGidDSRQRIPAHKFVLSIGSVVFDAMFNGGLtpkNTEEALEIELPDVEPSAFLALLKFLYSDEV 259
Cdd:cd18239    15 DQLRGEGLLCDVTLVPG--DGDETFPVHRAMMASASDYFKAMFTGGM---KEQELMCIKLHGVSKIGLKNIIDFIYTAKL 89

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1972267356 260 KIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18239    90 SLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLEN 127
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 187-297 1.33e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 47.89  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 187 TLADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGGLtpKNTEEAlEIELPDVEPSAFLALLKFLYSDEVKIEAESV 266
Cdd:cd18251    22 ILFDVVLVV----EGKPIEAHRILLAASCDYFRGMFAGGL--REMQQT-EVLIHGVSYNAMCKILDFIYTSELELSLDNV 94

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1972267356 267 MTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18251    95 QETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 185-290 1.62e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 46.95  E-value: 1.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 185 NETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLtPKNTEEALEIELPDVEPSAFLALLKFLYSDEVKIEAE 264
Cdd:cd18245    11 EPHLCDATLVVG----GEEIPVQKNVLAAASPYFRAKLNYNP-PKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSED 85

                          90       100
                  ....*....|....*....|....*.
gi 1972267356 265 SVMTTLYTAKKYAVPAMEKECVRFLK 290
Cdd:cd18245    86 NIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 202-276 3.00e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 45.35  E-value: 3.00e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972267356 202 QRIPAHKFVLSIGSVVFDAMFNGGLtpKNTEEAlEIELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKY 276
Cdd:cd01165     8 EKFHVNKELLAQSSEYFRALFRGGF--RESGQA-EINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 174-273 3.03e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 46.72  E-value: 3.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 174 TLRERIEHMYCNETLADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEealEIELPDVEPSAFLALLKF 253
Cdd:cd18276     7 TLLDQLNRMKELAELTDVVLVA----EGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQR---EVVLHDITAESVSIILNY 79

                          90       100
                  ....*....|....*....|
gi 1972267356 254 LYSDEVKIEAESVMTTLYTA 273
Cdd:cd18276    80 MYSSDLHLTNSNVQGVATAA 99
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 177-297 4.48e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 46.36  E-value: 4.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 177 ERIEHMYCNETLADVFFVVGiddSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYS 256
Cdd:cd18252    10 DAFRTFYLDGLFTDITLQCA---SGQIFHCHKAALAACSSYFKVMFTADMKEKSNNV---IKLSGIDHDILEALVNYVYT 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1972267356 257 DEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18252    84 SQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDN 124
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 175-297 7.52e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 45.38  E-value: 7.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 175 LRERIEHMYCNETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGL--TPKNteealEIELPDVEPSAFLALLK 252
Cdd:cd18343     8 LAEDLGNLWENSRFTDCSLFVG----GQEFKAHKSILAARSPVFNAMFEHEMeeSKKN-----RVEINDVDPEVFKEMMR 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1972267356 253 FLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18343    79 FIYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 204-301 7.62e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 45.55  E-value: 7.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 204 IPAHKFVLSIGSVVFDAMFNggltpKNTEEALE--IELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAM 281
Cdd:cd18268    35 IPCHRNVLASSSPYFRAMFC-----NNFRESSQakVDLKGIDSDVLDQIVDYVYTGEILITRDNVLPLMEAASMLQYPKL 109

                          90       100
                  ....*....|....*....|
gi 1972267356 282 EKECVRFLKQRLVPDNAFMM 301
Cdd:cd18268   110 FEACSLYLQDQLTPENCLSM 129
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 172-257 9.54e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 44.59  E-value: 9.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 172 KKTLRERIEHmycnETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMF-NGGLTPKNTEEALEIELPDVEPSAFLAL 250
Cdd:cd18301     6 KKLLDEADEG----DNIHDVVFQVG----GKTFPAHKFILASRSDYFRKLFlSSLLTSEDAVGCDVVHIEKVPPEIFEQL 77


                  ....*..
gi 1972267356 251 LKFLYSD 257
Cdd:cd18301    78 LQFIYTD 84
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 177-297 1.24e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 45.27  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 177 ERIEHMYCnetlaDVFFVVgiDDsrQRIPAHKFVLSIGSVVFDAMFNGGLtpkNTEEALEIELPDVEPSAFLALLKFLYS 256
Cdd:cd18266    19 QRQRGLFC-----DVVLVA--DE--QRVPAHRNLLAVCSDYFNSMFTIGM---REAHQKEVELVGASYIGLKAVIDFLYS 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1972267356 257 DEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18266    87 SELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEEN 127
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 185-291 2.59e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 43.40  E-value: 2.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 185 NETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYSDEVKIEAE 264
Cdd:cd18298     9 DPRTSDLKFRVD----GKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNV---IEIDQYSYPVYYAFLRYLYTDQVDLPPE 81

                          90       100
                  ....*....|....*....|....*..
gi 1972267356 265 SVMTTLYTAKKYAVPAMEKECVRFLKQ 291
Cdd:cd18298    82 DAIGLLDLANSYCEERLKKLCEDIIKQ 108
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 293-398 2.79e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 43.61  E-value: 2.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 293 LVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRI-REIFLFQAVLRWAKFEAe 371
Cdd:cd18446     1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVtEEEQVFETVMRWVRYKE- 79

                          90       100
                  ....*....|....*....|....*..
gi 1972267356 372 rrgmpangDSRRAVLSRSIPLIRFPLM 398
Cdd:cd18446    80 --------SERLPLLPRVLENVRLPLL 98
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 293-422 2.79e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 43.90  E-value: 2.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 293 LVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRI-REIFLFQAVLRWAKFEAE 371
Cdd:cd18513     1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVsSEEKVFEAVISWIKYDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1972267356 372 rrgmpangdSRRAVLSRSIPLIRFPLMKIDEFALHVEPSHILSDREMNKIF 422
Cdd:cd18513    81 ---------ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDF 122
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 200-295 3.08e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 44.25  E-value: 3.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 200 SRQRIPAHKFVLSIGSVVFDAMFNGGLTpknTEEALEIELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVP 279
Cdd:cd18246    47 GTKEIKAHKVVLASCSPYFHAMFTNEMS---ESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLN 123

                          90
                  ....*....|....*.
gi 1972267356 280 AMEKECVRFLKQRLVP 295
Cdd:cd18246   124 GVRDACCKFLLSQLDP 139
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 207-297 3.12e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 43.81  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 207 HKFVLSIGSVVFDAMFNGGLTPKNTEEALEIELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECV 286
Cdd:cd18258    32 HQNVLASCSLYFKDLIKRSSRDSGGGEKLELTMSNINADVLELLLEFVYTGSLIIDSANAKTLLEAANKFQFHTFCKVCV 111

                          90
                  ....*....|.
gi 1972267356 287 RFLKQRLVPDN 297
Cdd:cd18258   112 SFLEKQLTASN 122
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 174-302 3.31e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 43.84  E-value: 3.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 174 TLRERIEHMYCNETLADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGGLT-PKNTeealEIELPDVEPSAFLALLK 252
Cdd:cd18270    12 SLLEQLKFFYEQQLLTDIVLIV----EGTEFPCHKMVLATCSSYFRAMFMSGLSeSKQT----HVHLRNVDAATLQIIIT 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1972267356 253 FLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDNAFMML 302
Cdd:cd18270    84 YAYTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 177-273 3.31e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 43.87  E-value: 3.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 177 ERIEHMYCnetlaDVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGgltpkNTEEALEieLP-DVEPSAFLALLKFLY 255
Cdd:cd18289    23 QRLMGLYC-----DVSIVV----KGQAFKAHRAVLAASSLYFRDLFSG-----NSKSAFE--LPaTVPPACFQQILSFCY 86

                          90
                  ....*....|....*...
gi 1972267356 256 SDEVKIEAESVMTTLYTA 273
Cdd:cd18289    87 TGKLTMAASEQLVVMYTA 104
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 186-289 4.71e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 42.92  E-value: 4.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 186 ETLADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGGLtpKNTEEALEIElPDVEPSAFLALLKFLYSDEVKIEAES 265
Cdd:cd18331    22 DILTDVVIVV----SREQFRAHKTVLMACSGLFYSIFTDQL--KCNLSVINLD-PEINPEGFNILLDFMYTSRLNLREGN 94

                          90       100
                  ....*....|....*....|....
gi 1972267356 266 VMTTLYTAKKYAVPAMEKECVRFL 289
Cdd:cd18331    95 IMAVMATAMYLQMEHVVDTCRKFI 118
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 187-291 4.74e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 43.01  E-value: 4.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 187 TLADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTeeaLEIELPDVEPSAFLALLKFLYSDEVKIEAESV 266
Cdd:cd18295    18 SYSDVTFNV----HGESFPAHRCILSARSPYFAEMFETKWKDKRE---INLKHPLVNPDAFRALLQYLYTGRLEIHVDDV 90

                          90       100
                  ....*....|....*....|....*
gi 1972267356 267 mttlytakkyavpameKECVRFLKQ 291
Cdd:cd18295    91 ----------------EDCKRLAKQ 99
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 175-298 4.95e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 42.91  E-value: 4.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 175 LRERIEHMYCNETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEealEIELPDVEPSAFLALLKFL 254
Cdd:cd18345     5 LSDDLGLLFERSAFSDVTLCVG----GREFQAHKAILAARSPVFNAMFEHEMEERKQN---RVEITDVDHEVMREMLRFI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1972267356 255 YSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDNA 298
Cdd:cd18345    78 YTGKAPNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVENV 121
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 187-290 6.17e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 42.62  E-value: 6.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 187 TLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMfnggLTPKNTEEALEIELpdVEPSAFLALLKFLYSDEVKIEAESV 266
Cdd:cd18218    17 ALCDTLITVG----SQEFPAHSLVLAGASQQLGRQ----LTNPNPGQWCLGEG--ISPSTFKQLLDFVYGESVEVQPGEL 86

                          90       100
                  ....*....|....*....|....
gi 1972267356 267 MTTLYTAKKYAVPAMEKECVRFLK 290
Cdd:cd18218    87 RPLLEAARALEVESLEEACWRALG 110
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 186-268 6.48e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 42.55  E-value: 6.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 186 ETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFngglTPKNTEEALEIELPDVEPSAFLALLKFLYSDEVKIEAES 265
Cdd:cd18209    16 GQLCDVLLIVG----DQKFRAHKNVLAASSEYFQSLF----TEKENESQSVFQLDFCEPDAFENVLNYIYSSSLFVEKSS 87


                  ...
gi 1972267356 266 VMT 268
Cdd:cd18209    88 LAA 90
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 205-297 9.48e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 42.31  E-value: 9.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 205 PAHKFVLSIGSVVFDAMFNGGLtpkntEEALEIEL---PDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAM 281
Cdd:cd18254    35 PCHRAVLAACSRYFEAMFSNGL-----RESLDSTVnfhDSLHPEVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDV 109

                          90
                  ....*....|....*.
gi 1972267356 282 EKECVRFLKQRLVPDN 297
Cdd:cd18254   110 RDAAAEFLEKNLYPSN 125
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 292-367 1.19e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 40.84  E-value: 1.19e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1972267356 292 RLVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRI-REIFLFQAVLRWAK 367
Cdd:cd18463     1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVpKEEEVFEAVMRWVY 77
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 205-297 1.38e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 42.09  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 205 PAHKFVLSIGSVVFDAMFNggltpKNTEE--ALEIELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAME 282
Cdd:cd18264    41 PAHRSLLACSSDYFRALFK-----DYTQEskARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAI 115

                          90
                  ....*....|....*
gi 1972267356 283 KECVRFLKQRLVPDN 297
Cdd:cd18264   116 GLCSQYLINNLAPEN 130
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 202-298 1.50e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 42.01  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 202 QRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAM 281
Cdd:cd18342    32 QEFQAHKAILAARSPVFSAMFEHEMEESKKNR---VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERL 108

                          90
                  ....*....|....*..
gi 1972267356 282 EKECVRFLKQRLVPDNA 298
Cdd:cd18342   109 KVMCEDALCSNLSVENA 125
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 172-298 1.57e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 42.14  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 172 KKTLRERIE-HMYCNETLADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGGlTPKNTEEALEIELPDVEPSAFLAL 250
Cdd:cd18350     7 RKTLPARLDpHFLNNKEMSDVTFLV----EGKLFYAHKVLLVTASNRFKSLLTNK-SEQESQGSKTIEISDIKYHIFQML 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1972267356 251 LKFLY---SDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDNA 298
Cdd:cd18350    82 MQYLYyggTESMEIPIADVLELLSAASLFQLDALQRHCEILCSQTINLENA 132
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 297-370 1.60e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 40.57  E-value: 1.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972267356 297 NAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIR-EIFLFQAVLRWAKFEA 370
Cdd:cd18474     5 NCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRsEEVVLEAALRWVDADP 79
PHA03098 PHA03098
kelch-like protein; Provisional
 183-450 1.69e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 44.37  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 183 YCNETLadVFFVVGIddsrqRIPAHKFVLSIGSVVFDAMFNGGLTPKnteealEIELP-DVEpsAFLALLKFLYSDEVKI 261
Cdd:PHA03098    9 FCDESI--IIVNGGG-----IIKVHKIILSSSSEYFKKMFKNNFKEN------EINLNiDYD--SFNEVIKYIYTGKINI 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 262 EAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDT 341
Cdd:PHA03098   74 TSNNVKDILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 342 LCEVLTRDGLRI-REIFLFQAVLRWAKFEAerrgmpangDSRRAVLSRSIPLIRFPLmkidefalhvepshiLSDREMNK 420
Cdd:PHA03098  154 LIKILSDDKLNVsSEDVVLEIIIKWLTSKK---------NNKYKDICLILKVLRITF---------------LSEEGIKK 209

                         250       260       270
                  ....*....|....*....|....*....|
gi 1972267356 421 IFKYLavSPPDRPVLVYSDRPRCQISSTEY 450
Cdd:PHA03098  210 LKRWK--LRIKKKKIVFNKRCIKIIYSKKY 237
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 202-267 1.72e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 41.60  E-value: 1.72e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1972267356 202 QRIPAHKFVLSIGSVVFDAMFNGGLTPKNTeeaLEIELPDVEPS--AFLALLKFLYSDEVKIEAESVM 267
Cdd:cd18309    30 HPIPAHKAILAARCSYFEAMFRSFMPEDNT---VNISIGEMVPSrqAFDSLLRYIYYGDVTMPPEDSL 94
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 189-285 1.77e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 41.31  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 189 ADVFFVVGIDDSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEALEieLPDVEPSAFLALLKFLYSDEVKIEAESVMT 268
Cdd:cd18293    12 SGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVLE--LQGLKAHTLLKLVDFLYTSELEVSSEEAQD 89

                          90
                  ....*....|....*..
gi 1972267356 269 TLYTAKKYAVPAMEKEC 285
Cdd:cd18293    90 VLAAARRLQISELESLC 106
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 177-290 1.80e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 41.56  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 177 ERIEHMYCnetlaDVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNggltpknTEEALEIELP-DVEPSAFLALLKFLY 255
Cdd:cd18290    21 QRLQGLYC-----DVSVVV----KGHAFKAHRAVLAASSSYFRDLFN-------SSRSAVVELPaAVQPQSFQQILSFCY 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1972267356 256 SDEVKIEAESVMTTLYTAKKYAVPA-MEKECVRFLK 290
Cdd:cd18290    85 TGRLSMNVGDQFLLMYTAGFLQIQEiMEKGTEFFLK 120
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 205-273 2.37e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 41.11  E-value: 2.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972267356 205 PAHKFVLsIGSVVFDAMFNGGLTPKNTEEaLEIELPD--VEPSAFLALLKFLYSDEVKIEAESVMTTLYTA 273
Cdd:cd18305    28 KLHKIYL-CQSGYFASMFSGSWKESKETV-INLEIPDdnITVEALNVVFGSLYRDEIEIKPSRVVSILAAA 96
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 185-289 2.73e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 41.07  E-value: 2.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 185 NETLADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGGLTpKNTEEALEIELpdVEPSAFLALLKFLYSDEVKIEAE 264
Cdd:cd18326    22 QGLLCDVVILV----EGREFPTHRSVLAACSQYFKKLFTSGAV-VDQQNVYEIDF--VSAEALTALLDFAYTATLTVSTS 94

                          90       100
                  ....*....|....*....|....*
gi 1972267356 265 SVMTTLYTAKKYAVPAMEKECVRFL 289
Cdd:cd18326    95 NVGDILSAARLLEIPAVSHVCADLL 119
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 190-291 2.99e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 41.10  E-value: 2.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 190 DVFFVVGiDDSrqrIPAHKFVLSIGSVVFDAMFNGGLTPKNteEALEIELPDVEPSAFLALLKFLYSDEVKIEAESVMTT 269
Cdd:cd18207    29 DVLLRVG-EES---FPAHRAVLAACSEYFESVFSAQEGDGG--TPRELEMHTISSKVFGDILDFAYTSRIVVRLESFPEL 102

                          90       100
                  ....*....|....*....|..
gi 1972267356 270 LYTAKKYAVPAMEKECVRFLKQ 291
Cdd:cd18207   103 MTAAKFLLMRSVIDICQEVIKQ 124
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 188-293 3.10e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 40.60  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 188 LADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGgltpkNTEEALEIELP--DVEPSAFLALLKFLYSDE-VKIEAE 264
Cdd:cd18360    10 LADVVFKI----QGTTVPAHRAVLVARCEVMAAMFNG-----NYAEAKSFLVPiyGVSKDTFLSFLEYLYTDScCPASIL 80

                          90       100
                  ....*....|....*....|....*....
gi 1972267356 265 SVMTTLYTAKKYAVPAMEKECVRFLKQRL 293
Cdd:cd18360    81 QAMALLICAEMYQVSRLQHICELYIITQL 109
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 172-285 3.16e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 41.12  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 172 KKTLRERIE-HMYCNETLADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMfnggLTPKNTEEALEIELPDVEPSAFLAL 250
Cdd:cd18351     7 KRKQTSRLDpHFLNNKEMSDVTFLV----EGRPFYAHKVLLFTASPRFKAL----LSNKPSAENTCIEISYVKYHIFQLV 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1972267356 251 LKFLY---SDEVKIEAESVMTTLYTAKKYAVPAMEKEC 285
Cdd:cd18351    79 MQYLYcggTESLLIKNNEIMELLSAAKFFQLEALQRHC 116
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 312-373 3.28e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 39.97  E-value: 3.28e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1972267356 312 DLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIR-EIFLFQAVLRWAKFEAERR 373
Cdd:cd18458    21 ELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRcESEVYNAVIRWVKYDEENR 83
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 188-289 3.60e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 39.76  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 188 LADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGgltpkNTEEALEIELPD-VEPSAFLALLKFLYSDEVKIEAESV 266
Cdd:cd18955     1 LCDVTIVVE----DQRFRAHRAVLAACSDYFLSRVVG-----QTDGDLVITLPEeVTVKGFEPLLQFAYTAKLLLSKENV 71

                          90       100
                  ....*....|....*....|...
gi 1972267356 267 MTTLYTAKKYAVPAMEKECVRFL 289
Cdd:cd18955    72 LEVCRCAEFLGVHNIEKACFDFL 94
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 177-283 3.69e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 40.54  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 177 ERIEHMYCnetlaDVFFVVgiDDSRQRipAHKFVLSIGSVVFDAMFnggLTPKNTEEALEIELPDVEPSAFLALLKFLYS 256
Cdd:cd18223    12 QRIQGILC-----DVTIVV--EDTKFK--AHKNVLAASSLYFKNAF---SSQEIWISSHVLELPDLKAEVFAEILNFIYS 79

                          90       100
                  ....*....|....*....|....*...
gi 1972267356 257 DEVKIEAESVMTTLYTA-KKYAVPAMEK 283
Cdd:cd18223    80 SKVVVKRQETVTDLVAAgKKLGITFLEN 107
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 293-399 4.67e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 39.98  E-value: 4.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 293 LVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRIR-EIFLFQAVLRWAKFEAE 371
Cdd:cd18457     1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKsEEQVFEAALAWVKYDRE 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1972267356 372 RRG--MPangdsrrAVLSRsiplIRFPLMK 399
Cdd:cd18457    81 NREeyLP-------ELLSK----VRLPLLR 99
BTB_POZ_BTBD16 cd18291
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 235-297 6.38e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 16 (BTBD16); BTBD16 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349600  Cd Length: 114  Bit Score: 39.73  E-value: 6.38e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1972267356 235 LEIELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRLVPDN 297
Cdd:cd18291    48 LNINDPLVTKEAFAVALGNLYNSEVEVNVEDAVGVLAAAALLRFPTLFQKCVKVMISSISSST 110
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 206-295 7.01e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 39.80  E-value: 7.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 206 AHKFVLSIGSVVFDAMFNGGLtpKNTEEAlEIELPDVEPSAFLALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKEC 285
Cdd:cd18263    27 VHRVILAAGSDYFRAMFTSGM--KESTQS-VVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQLQISGALALC 103

                          90
                  ....*....|
gi 1972267356 286 VRFLKQRLVP 295
Cdd:cd18263   104 LDFLQREISP 113
BTB_POZ_BT cd18313
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 194-293 7.74e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5; BT1-5 may act as substrate-specific adaptors of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. They contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349622 [Multi-domain]  Cd Length: 102  Bit Score: 39.00  E-value: 7.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 194 VVGIDDSRQRIPAHKFVLSIGSVVFDAMFNgglTPKNTEEALEIELPDVEPSAFLALLKFLYSDEVKIE--AESVMTTLY 271
Cdd:cd18313     4 VEIETDNNSHIPAHSNVLASASPVIAGMLK---QPRRKSSKKVIKILGVPCDAVRVFIRFLYSSCYEEEemEKFGIHLLV 80

                          90       100
                  ....*....|....*....|..
gi 1972267356 272 TAKKYAVPAMEKECVRFLKQRL 293
Cdd:cd18313    81 LSHVYVVPQLKRVCEKGLEQGL 102
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 169-291 7.89e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 39.55  E-value: 7.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 169 QADKKTLRERIEHMYCNETLADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGGLTpKNTEEALEIElpDVEPSAFL 248
Cdd:cd18353     1 HDDFLTVAESLKKEFDSPETSDLKFRV----DGKYIHVHKAVLKIRCEHFRTMFQSHWN-EDMKEVIEID--QFSYPVYR 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1972267356 249 ALLKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQ 291
Cdd:cd18353    74 AFLEYLYTDSVDLPPEDAIGLLDLATSYCENRLKKLCQHIIKR 116
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 171-291 7.94e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 39.54  E-value: 7.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 171 DKKTLRERIEHMYCNETLADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNggltpkNTEEALeIELPDVEPSAFLAL 250
Cdd:cd18354     3 DHLTVAESLKREFDNPDTADLKFLV----DGKYIYVHKVLLKIRCEHFRSLLN------ENEEEI-IEMSQFSYPVYRAF 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1972267356 251 LKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQ 291
Cdd:cd18354    72 LEYLYTDSISLSPEDAIGLLDLATFYRENRLKKLCQQTIKQ 112
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 176-288 8.86e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 39.36  E-value: 8.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 176 RERIEHMYCNETLadvffVVGIDDSRqripAHKFVLSIGSVVFDAMFNGGLtpknteeALEIELPDVEPSAFLALLKFLY 255
Cdd:cd18232    11 KQREEGQYCDATL-----DVGGRVFK----AHWSVLACCSHFFQSLYGDGT-------SGSVVLPESFAEVFGLLLDFFY 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1972267356 256 SDEVKIEAESVMTTLYTAKKYAVPAMEKECVRF 288
Cdd:cd18232    75 TGELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 293-402 9.07e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 38.95  E-value: 9.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 293 LVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKNTLEALNGE----GFTEIDLDTLCEVLTRDGL-RIREIFLFQAVLRWAK 367
Cdd:cd18473     1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRLLASDaddaGLLELNLESLQAVLEADDIpRVKESRLLTLVLEWLN 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1972267356 368 FEAERrgmPANGDsrrAVLSRsiplIRFPLMKIDE 402
Cdd:cd18473    81 QDESR---LAYAN---ALLSR----IRYGLVPVEE 105
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 311-369 9.08e-04

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 38.16  E-value: 9.08e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 311 PDLMQKCLEVIDKNTLEALNGEGFTEIDLDTLCEVLTRDGLRI-REIFLFQAVLRWAKFE 369
Cdd:cd18508    18 VELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVpSEERVYEAAVAWLKHD 77
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 293-369 9.47e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 38.36  E-value: 9.47e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1972267356 293 LVPDNAFMMLSQAKLFDEPDLMQKCLEVIDKN-TLEALNGEGFTEIDLDTLCEVLTRDGLRIR-EIFLFQAVLRWAKFE 369
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPELERKAYRYILRNfEEVAKDSEEFLELSCEELEDIIEDDELNVKeEEVVFEAIVKWIDHD 79
BTB_POZ_BTBD12_SLX4 cd18288
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 182-285 1.30e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349597 [Multi-domain]  Cd Length: 116  Bit Score: 38.98  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 182 MYCNETLADVFFVVgidDSRQRIPAHKFVL-SIGSVVFDAMFNGGLTPKN--TEEALEIELPDVEPSAFLALLKFLYSDE 258
Cdd:cd18288    12 MVNNPHLSDVQFQT---DSGEVLYAHSFVLyARCPLLIQMVHSEGFSVEEegGVTTRRVLLGDVSGEAARCFLQYLYTAD 88

                          90       100
                  ....*....|....*....|....*..
gi 1972267356 259 VKIEAESVMTTLYTAKKYAVPAMEKEC 285
Cdd:cd18288    89 TGLPPGLSPHVSELADRFGVSELVHLC 115
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 189-255 1.53e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 38.25  E-value: 1.53e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1972267356 189 ADVFFVVgidDSRQRIPAHKFVLSIGSVVFDAMFNGGLTPKNTEealEIELPDVEPSAFLALLKFLY 255
Cdd:cd18191     2 HDLRFLL---DGGTQLPASRAALTGASEVFRAMLEGGFAEAQQD---LVPLRQVPSGAFLPVLHYLH 62
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 190-289 1.63e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 39.05  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 190 DVFFVVGIDDSRQRIPAHKFVLSIGSVVFDAMFNggLTPKNTEEAlEIELPDVEPSAFLALLKFLYSDEVKIEAESVMTT 269
Cdd:cd18271    22 NAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFE--VNMKERDDG-SVTISNLSPKAVKAFLDYAYTGKAEITDDNVEMF 98

                          90       100
                  ....*....|....*....|
gi 1972267356 270 LYTAKKYAVPAMEKECVRFL 289
Cdd:cd18271    99 FQMSSFLQVSLLSKACSDFL 118
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 321-396 1.74e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 38.17  E-value: 1.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1972267356 321 IDKNTLEALNGEGFTEIDLDTLCEVLTRDGLR-IREIFLFQAVLRWAKFEAERRGMPAngdsrrAVLSRsiplIRFP 396
Cdd:cd18449    29 ILKNFPALLSTGDFVKLPFERLAFVLSSNSLKgCTELELFKAACRWLRHEDDRMQFAA------KLMEN----IRFP 95
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 177-293 1.86e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 39.07  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 177 ERIEHMYCNETLAdvffvVGIDDSRQrIPAHKFVLSIGSVVFDAMFNGGLTPKNTEEaleIEL------PDVEPSAFLAL 250
Cdd:cd18241    17 QRKQGLFCDITLA-----FGGAGGRE-FRAHRSVLAAATEYFTPLLSGQFSESRSGR---VEMrkwssePGPDPDTVEAV 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1972267356 251 LKFLYSDEVKIEAESVMTTLYTAKKYAVPAMEKECVRFLKQRL 293
Cdd:cd18241    88 IQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKL 130
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 188-289 2.09e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 38.32  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 188 LADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGGlTPKNTEEALEIELpdVEPSAFLALLKFLYSDEVKIEAESVM 267
Cdd:cd18328    25 LCDVVLIV----QDQEYRTHRSVLAACSKYFKKLFTAG-TLADQPYVYEIDF--VTPEALSAILEFAYTSTLTITTSNVK 97

                          90       100
                  ....*....|....*....|..
gi 1972267356 268 TTLYTAKKYAVPAMEKECVRFL 289
Cdd:cd18328    98 HILNAAQMLEIQCIINVCLEIM 119
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 206-298 2.24e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 38.40  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 206 AHKFVLSIGSVVFDAMFNggltpKNTEEALE--IELPDVEPSAFLALLKFLYSDEV-KIEAESVMT-TLYTAKKYAVPAM 281
Cdd:cd18344    37 AHKAILAARSPVFRAMFE-----HEMEERLKnpIEIHDLDPQVFKEMMGFIYTGKApHLHSHSMACdVLAAADKYGLEGL 111

                          90
                  ....*....|....*..
gi 1972267356 282 EKECVRFLKQRLVPDNA 298
Cdd:cd18344   112 KVLCEDALCRNLSVENA 128
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 188-289 2.31e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 38.39  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 188 LADVFFVVgiddSRQRIPAHKFVLSIGSVVFDAMFNGgltpkNTEEALEIELPD-VEPSAFLALLKFLYSDEVKIEAESV 266
Cdd:cd18278    31 LCDVTLIV----EGKEFRAHRAVLAACSEYFLQALVG-----QTENDLVVSLPEeVTARGFGPLLQFAYTAKLLLSRENI 101

                          90       100
                  ....*....|....*....|...
gi 1972267356 267 MTTLYTAKKYAVPAMEKECVRFL 289
Cdd:cd18278   102 QEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 187-289 3.01e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 37.71  E-value: 3.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 187 TLADVFFVVgidDSrQRIPAHKFVLSIGSVVFDAMFNggltpKNTEEaleIELPDVEPSAFLALLKFLYSDEVKIEAESV 266
Cdd:cd18205    17 TLCDVVIMV---DS-QEFHAHRTVLACTSKMFEILFH-----RNSQH---YTLDFLSPKTFQQILEYAYTATLQAKVEDL 84

                          90       100
                  ....*....|....*....|...
gi 1972267356 267 MTTLYTAKKYAVPAMEKECVRFL 289
Cdd:cd18205    85 DDLLYAAEILEIEYLEEQCLKIL 107
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 324-398 3.02e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 37.70  E-value: 3.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972267356 324 NTLEALNGEGFTEIDLDTLCEVLTRDGLRI-REIFLFQAVLRWAKFEAerrgmpangDSRRAVLSRSIPLIRFPLM 398
Cdd:cd18444    33 HFMEVIQNQEFLLLPAEEVAKLLASDDLNVpSEETIFHALLLWVKHDL---------PERKKHLAKLLALIRLPLL 99
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 188-288 3.79e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 37.55  E-value: 3.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 188 LADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGLtpKNTEEALEIElPDVEPSAFLALLKFLYSDEVKIEAESVM 267
Cdd:cd18215    19 LTDVVLVVG----REQFRAHKTVLMACSGLFYSIFTDQL--KNNVSVINLD-PEIEPEGFRILLDFMYTSRLNLREGNIM 91

                          90       100
                  ....*....|....*....|.
gi 1972267356 268 TTLYTAKKYAVPAMEKECVRF 288
Cdd:cd18215    92 AVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 188-295 6.43e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 37.33  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 188 LADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGGlTPKNTEEALEIELPDVEPSAFLALLKFLYSDEVKIEAESVM 267
Cdd:cd18196    21 LCDCVIVVG----NRHFKAHRSVLAACSTHFRALFTVA-EGDQTMNMIQLDSEVVTAEAFAALIDMMYTSTLMLGESNVM 95

                          90       100
                  ....*....|....*....|....*...
gi 1972267356 268 TTLYTAKKYAVPAMEKECVRFLKQRLVP 295
Cdd:cd18196    96 DVLLAASHLHLNSVVKACKHYLTTRTLP 123
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 186-290 6.98e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 36.76  E-value: 6.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972267356 186 ETLADVFFVVGiddsRQRIPAHKFVLSIGSVVFDAMFNGgltpKNTEEALEIELPD-VEPSAFLALLKFLYSDEVKIEAE 264
Cdd:cd18332    17 DILTDVTLLVG----GTPLRAHKAVLIACSGFFYSIFSG----RVGEGVSVLTLPSgLEARGFQLLLDFMYTSRLPLTPR 88

                          90       100
                  ....*....|....*....|....*.
gi 1972267356 265 SVMTTLYTAKKYAVPAMEKECVRFLK 290
Cdd:cd18332    89 TVPAVLAAATYLQMEHVVETCRRFIQ 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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