NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1917203257|ref|NP_001375008|]
View 

general transcription factor II-I repeat domain-containing protein 2A isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 107-181 3.65e-41

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 145.06  E-value: 3.65e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917203257 107 LRKAVEDYFCFCYGKALGTTVMVPVPYEKMLRDQSAVVVQGLPEGVAFQHPENYDLATLKWILENKAGISFIINR 181
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I super family cl08383
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 332-406 4.55e-20

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


The actual alignment was detected with superfamily member pfam02946:

Pssm-ID: 460759  Cd Length: 75  Bit Score: 84.97  E-value: 4.55e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917203257 332 LREQVNDLFSRKFGEAIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILEAAEFIKFTVIR 406
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
DUF4371 super family cl46273
Domain of unknown function (DUF4371);
552-635 1.15e-05

Domain of unknown function (DUF4371);


The actual alignment was detected with superfamily member pfam14291:

Pssm-ID: 480613  Cd Length: 236  Bit Score: 47.61  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203257 552 YSIAIDEITDINNTTQLAIFIRGVDENFDVSEELLDTVPMTGTKSGNeIFSRVEKSLKNFCIDWSKLVSVASTGTPAMVD 631
Cdd:pfam14291 154 FGILVDETADASDKEQMAIVFRYVDKYGVPIERFIGVIHVQETSSLS-LKSAIDSLLKSLGISLKKLRSQCYDGASNMSG 232


                  ....
gi 1917203257 632 ANNG 635
Cdd:pfam14291 233 EFNG 236
DUF4371 super family cl46273
Domain of unknown function (DUF4371);
434-496 3.50e-04

Domain of unknown function (DUF4371);


The actual alignment was detected with superfamily member pfam18658:

Pssm-ID: 480613  Cd Length: 64  Bit Score: 39.56  E-value: 3.50e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917203257 434 QEKWERAYFFVEVQNIPT--CLICKQSMSVSKEYNLRRHYQTNHsKHYDQYMERMRDEKLHELKK 496
Cdd:pfam18658   1 QERWRLEYLMDYDPGRNGlvCMVCGESLASLKLSTIKRHILQKH-PDTLSLSPEEKEAILEAWEE 64
 
Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 107-181 3.65e-41

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 145.06  E-value: 3.65e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917203257 107 LRKAVEDYFCFCYGKALGTTVMVPVPYEKMLRDQSAVVVQGLPEGVAFQHPENYDLATLKWILENKAGISFIINR 181
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 332-406 4.55e-20

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 84.97  E-value: 4.55e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917203257 332 LREQVNDLFSRKFGEAIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILEAAEFIKFTVIR 406
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
DUF4371 pfam14291
Domain of unknown function (DUF4371);
552-635 1.15e-05

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 47.61  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203257 552 YSIAIDEITDINNTTQLAIFIRGVDENFDVSEELLDTVPMTGTKSGNeIFSRVEKSLKNFCIDWSKLVSVASTGTPAMVD 631
Cdd:pfam14291 154 FGILVDETADASDKEQMAIVFRYVDKYGVPIERFIGVIHVQETSSLS-LKSAIDSLLKSLGISLKKLRSQCYDGASNMSG 232


                  ....
gi 1917203257 632 ANNG 635
Cdd:pfam14291 233 EFNG 236
zf-C2H2_12 pfam18658
Spin-doc zinc-finger; This is a zinc finger domain C2H2 type which can be found in SPIN1 ...
 434-496 3.50e-04

Spin-doc zinc-finger; This is a zinc finger domain C2H2 type which can be found in SPIN1 docking protein (SPIN-DOC) and Epm2a-interacting protein 1 (Epm2aip1). SPIN-DOC is a Spindlin1 (SPIN1) regulator that directly binds and strongly disrupts its histone methylation reading ability, causing it to disassociate from chromatin. Epm2aip1 is a glycogen synthase (GS)-associated protein. In the absence of Epm2aip1, the sensitivity of the liver to insulin, in which GS is a principal actor, is impaired.


Pssm-ID: 465831  Cd Length: 64  Bit Score: 39.56  E-value: 3.50e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917203257 434 QEKWERAYFFVEVQNIPT--CLICKQSMSVSKEYNLRRHYQTNHsKHYDQYMERMRDEKLHELKK 496
Cdd:pfam18658   1 QERWRLEYLMDYDPGRNGlvCMVCGESLASLKLSTIKRHILQKH-PDTLSLSPEEKEAILEAWEE 64
 
Name Accession Description Interval E-value
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 107-181 3.65e-41

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 145.06  E-value: 3.65e-41
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917203257 107 LRKAVEDYFCFCYGKALGTTVMVPVPYEKMLRDQSAVVVQGLPEGVAFQHPENYDLATLKWILENKAGISFIINR 181
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
GTF2I pfam02946
GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of ...
 332-406 4.55e-20

GTF2I-like repeat; This region of sequence similarity is found up to six times in a variety of proteins including GTF2I. It has been suggested that this may be a DNA binding domain.


Pssm-ID: 460759  Cd Length: 75  Bit Score: 84.97  E-value: 4.55e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917203257 332 LREQVNDLFSRKFGEAIGVDFPVKVPYRKITFNPGCVVIDGMPPGVVFKAPGYLEISSMRRILEAAEFIKFTVIR 406
Cdd:pfam02946   1 LRKQVEELFNVKYGEALGLSSPVPVPYEKFQRDPEDLYVEGLPEGVPFRRPSTYDIPTLEKILEASSRISFVIKR 75
DUF4371 pfam14291
Domain of unknown function (DUF4371);
552-635 1.15e-05

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 47.61  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1917203257 552 YSIAIDEITDINNTTQLAIFIRGVDENFDVSEELLDTVPMTGTKSGNeIFSRVEKSLKNFCIDWSKLVSVASTGTPAMVD 631
Cdd:pfam14291 154 FGILVDETADASDKEQMAIVFRYVDKYGVPIERFIGVIHVQETSSLS-LKSAIDSLLKSLGISLKKLRSQCYDGASNMSG 232


                  ....
gi 1917203257 632 ANNG 635
Cdd:pfam14291 233 EFNG 236
zf-C2H2_12 pfam18658
Spin-doc zinc-finger; This is a zinc finger domain C2H2 type which can be found in SPIN1 ...
 434-496 3.50e-04

Spin-doc zinc-finger; This is a zinc finger domain C2H2 type which can be found in SPIN1 docking protein (SPIN-DOC) and Epm2a-interacting protein 1 (Epm2aip1). SPIN-DOC is a Spindlin1 (SPIN1) regulator that directly binds and strongly disrupts its histone methylation reading ability, causing it to disassociate from chromatin. Epm2aip1 is a glycogen synthase (GS)-associated protein. In the absence of Epm2aip1, the sensitivity of the liver to insulin, in which GS is a principal actor, is impaired.


Pssm-ID: 465831  Cd Length: 64  Bit Score: 39.56  E-value: 3.50e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1917203257 434 QEKWERAYFFVEVQNIPT--CLICKQSMSVSKEYNLRRHYQTNHsKHYDQYMERMRDEKLHELKK 496
Cdd:pfam18658   1 QERWRLEYLMDYDPGRNGlvCMVCGESLASLKLSTIKRHILQKH-PDTLSLSPEEKEAILEAWEE 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH