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Conserved domains on  [gi|1915468776|ref|NP_001374682|]
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dematin isoform 1 [Homo sapiens]

Protein Classification

actin-binding LIM protein; villin family protein( domain architecture ID 11241350)

actin-binding LIM protein (abLIM) may act as a scaffold protein for signaling modules of the actin cytoskeleton| villin family protein similar to Oryza sativa villin-4, a Ca(2+)-regulated actin-binding protein involved in actin filament bundling, severing and capping

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AbLIM_anchor pfam16182
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ...
 8-355 3.29e-88

Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types.


:

Pssm-ID: 465046 [Multi-domain]  Cd Length: 319  Bit Score: 270.11  E-value: 3.29e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776   8 PLTSPGSVSPSRDSSVPGSPSS-IVAKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEhvELPRSRERSL 86
Cdd:pfam16182   1 TRTSSESIISPPGSSISGSPSRvIYAKLDNEILDYKDLAALPKVKAIYDIERPDLISYEPYVSYSSDD--RLERQSYGES 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776  87 SPKSTSPPPSP-----EVWADSRSPGIISQASAPRTTGTPRTS--LPHFHHPET-------------------------- 133
Cdd:pfam16182  79 LSTLSPSSEDSydsreLRQRRSSSPGSIGSPTYSRHGYTPTLSrsPQHFHRPGSesgrsspslsqpsdrkspptyvqapk 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776 134 ------SRPDSNIYKKPPIYKQRESVGGSPQTkhliEDLIIESSKFPAAqppdpnqpakietdywpcppslAVVETEWRk 207
Cdd:pfam16182 159 hfhvpdTGVKDNIYRKPPIYKQHGTSASASQS----SEDIIHSSRFPAS----------------------GGEEEGWN- 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776 208 rkasrrgaeeeeeeedddsgeemkaLRERQREELSKVTSNLGKMILKEEME-KSLPIRRKTRSLPDRTPFHTSL-HQGTS 285
Cdd:pfam16182 212 -------------------------RRLLQEEELSKIQSGLGKLILKEEMEaRSGSERRDPWSSPRSSPSGSSGsDSPYS 266

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776 286 KSSSLPAYGRTTLSRLQSTEFSPSGSETGSpglqngegqrgrmdrgnSLPCVLEQKIYPYEMLVVTNKGR 355
Cdd:pfam16182 267 KSASLPGYGRNGLHRPQSADFFQYGSDGDV-----------------SWGGMREYKIYPYEMLAVTNRGR 319
VHP smart00153
Villin headpiece domain;
370-405 8.89e-15

Villin headpiece domain;


:

Pssm-ID: 128458  Cd Length: 36  Bit Score: 67.73  E-value: 8.89e-15
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1915468776  370 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 405
Cdd:smart00153   1 YLSDEDFEEVFGMTREEFYKLPLWKQNQLKKKKGLF 36
 
Name Accession Description Interval E-value
AbLIM_anchor pfam16182
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ...
 8-355 3.29e-88

Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types.


Pssm-ID: 465046 [Multi-domain]  Cd Length: 319  Bit Score: 270.11  E-value: 3.29e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776   8 PLTSPGSVSPSRDSSVPGSPSS-IVAKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEhvELPRSRERSL 86
Cdd:pfam16182   1 TRTSSESIISPPGSSISGSPSRvIYAKLDNEILDYKDLAALPKVKAIYDIERPDLISYEPYVSYSSDD--RLERQSYGES 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776  87 SPKSTSPPPSP-----EVWADSRSPGIISQASAPRTTGTPRTS--LPHFHHPET-------------------------- 133
Cdd:pfam16182  79 LSTLSPSSEDSydsreLRQRRSSSPGSIGSPTYSRHGYTPTLSrsPQHFHRPGSesgrsspslsqpsdrkspptyvqapk 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776 134 ------SRPDSNIYKKPPIYKQRESVGGSPQTkhliEDLIIESSKFPAAqppdpnqpakietdywpcppslAVVETEWRk 207
Cdd:pfam16182 159 hfhvpdTGVKDNIYRKPPIYKQHGTSASASQS----SEDIIHSSRFPAS----------------------GGEEEGWN- 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776 208 rkasrrgaeeeeeeedddsgeemkaLRERQREELSKVTSNLGKMILKEEME-KSLPIRRKTRSLPDRTPFHTSL-HQGTS 285
Cdd:pfam16182 212 -------------------------RRLLQEEELSKIQSGLGKLILKEEMEaRSGSERRDPWSSPRSSPSGSSGsDSPYS 266

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776 286 KSSSLPAYGRTTLSRLQSTEFSPSGSETGSpglqngegqrgrmdrgnSLPCVLEQKIYPYEMLVVTNKGR 355
Cdd:pfam16182 267 KSASLPGYGRNGLHRPQSADFFQYGSDGDV-----------------SWGGMREYKIYPYEMLAVTNRGR 319
VHP smart00153
Villin headpiece domain;
370-405 8.89e-15

Villin headpiece domain;


Pssm-ID: 128458  Cd Length: 36  Bit Score: 67.73  E-value: 8.89e-15
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1915468776  370 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 405
Cdd:smart00153   1 YLSDEDFEEVFGMTREEFYKLPLWKQNQLKKKKGLF 36
VHP pfam02209
Villin headpiece domain;
370-405 6.19e-13

Villin headpiece domain;


Pssm-ID: 460493  Cd Length: 36  Bit Score: 62.40  E-value: 6.19e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1915468776 370 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 405
Cdd:pfam02209   1 YLSDEDFEEVFGMSREEFYKLPKWKQNNLKKKAGLF 36
 
Name Accession Description Interval E-value
AbLIM_anchor pfam16182
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ...
 8-355 3.29e-88

Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types.


Pssm-ID: 465046 [Multi-domain]  Cd Length: 319  Bit Score: 270.11  E-value: 3.29e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776   8 PLTSPGSVSPSRDSSVPGSPSS-IVAKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEhvELPRSRERSL 86
Cdd:pfam16182   1 TRTSSESIISPPGSSISGSPSRvIYAKLDNEILDYKDLAALPKVKAIYDIERPDLISYEPYVSYSSDD--RLERQSYGES 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776  87 SPKSTSPPPSP-----EVWADSRSPGIISQASAPRTTGTPRTS--LPHFHHPET-------------------------- 133
Cdd:pfam16182  79 LSTLSPSSEDSydsreLRQRRSSSPGSIGSPTYSRHGYTPTLSrsPQHFHRPGSesgrsspslsqpsdrkspptyvqapk 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776 134 ------SRPDSNIYKKPPIYKQRESVGGSPQTkhliEDLIIESSKFPAAqppdpnqpakietdywpcppslAVVETEWRk 207
Cdd:pfam16182 159 hfhvpdTGVKDNIYRKPPIYKQHGTSASASQS----SEDIIHSSRFPAS----------------------GGEEEGWN- 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776 208 rkasrrgaeeeeeeedddsgeemkaLRERQREELSKVTSNLGKMILKEEME-KSLPIRRKTRSLPDRTPFHTSL-HQGTS 285
Cdd:pfam16182 212 -------------------------RRLLQEEELSKIQSGLGKLILKEEMEaRSGSERRDPWSSPRSSPSGSSGsDSPYS 266

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1915468776 286 KSSSLPAYGRTTLSRLQSTEFSPSGSETGSpglqngegqrgrmdrgnSLPCVLEQKIYPYEMLVVTNKGR 355
Cdd:pfam16182 267 KSASLPGYGRNGLHRPQSADFFQYGSDGDV-----------------SWGGMREYKIYPYEMLAVTNRGR 319
VHP smart00153
Villin headpiece domain;
370-405 8.89e-15

Villin headpiece domain;


Pssm-ID: 128458  Cd Length: 36  Bit Score: 67.73  E-value: 8.89e-15
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1915468776  370 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 405
Cdd:smart00153   1 YLSDEDFEEVFGMTREEFYKLPLWKQNQLKKKKGLF 36
VHP pfam02209
Villin headpiece domain;
370-405 6.19e-13

Villin headpiece domain;


Pssm-ID: 460493  Cd Length: 36  Bit Score: 62.40  E-value: 6.19e-13
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1915468776 370 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 405
Cdd:pfam02209   1 YLSDEDFEEVFGMSREEFYKLPKWKQNNLKKKAGLF 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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