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Conserved domains on  [gi|1908918739|ref|NP_001374148|]
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uncharacterized protein C16orf96 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4795 pfam16043
Domain of unknown function (DUF4795); This family of proteins is functionally uncharacterized. ...
 729-919 3.70e-53

Domain of unknown function (DUF4795); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 285 and 978 amino acids in length.


:

Pssm-ID: 464990 [Multi-domain]  Cd Length: 181  Bit Score: 184.04  E-value: 3.70e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  729 TTVDILQKKIGSLQksrlkeEELERIWGNQIEMMKDryitldkavenLQIRMDEFKTLQAQIKRLEMNKVNKSTMEEELR 808
Cdd:pfam16043    7 ELLDQLQALILDLQ------EELEKLSETTSELSER-----------LQQRQKHLEALYQQIEKLEKVKADKEVVEEELD 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  809 EKADRSALAGKASRVDLETVALELNEMIQGILFKVTIHEDSWKKAMEELSKDVNTKLVHSDLDPLKKEMEEVWKIVRKLL 888
Cdd:pfam16043   70 EKADKEALASKVSRDQFDETLEELNQMLQELLDKLEGQEDAWKKALETLSEELDTKLDRLELDPLKELLERRIKALQKLL 149

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1908918739  889 IEGLRLDPD-SAAGFRRKLFKRVKCISCDRPV 919
Cdd:pfam16043  150 QEGSEELDEaEAAGFRKKLLERFHCISCDRPV 181
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 286-436 7.24e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 7.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  286 PELLPEGSSAQAVSLSRaQEPAQPPALTP--ESAPGCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGPSVTPGSL 363
Cdd:PHA03247  2848 PSLPLGGSVAPGGDVRR-RPPSRSPAAKPaaPARPPVRRLARPAVSRSTESFA--------LPPDQPERPPQPQAPPPPQ 2918

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  364 PAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRvGSWPLWDLGVLRP----------TQPQPSR---APPPATEF 430
Cdd:PHA03247  2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS-GAVPQPWLGALVPgrvavprfrvPQPAPSReapASSTPPLT 2997


                   ....*.
gi 1908918739  431 GSLWPR 436
Cdd:PHA03247  2998 GHSLSR 3003
RRM_SF super family cl17169
RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP ...
 248-284 5.76e-04

RNA recognition motif (RRM) superfamily; RRM, also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).


The actual alignment was detected with superfamily member cd12517:

Pssm-ID: 473069 [Multi-domain]  Cd Length: 76  Bit Score: 39.65  E-value: 5.76e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1908918739  248 PEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYE 284
Cdd:cd12517     40 PEAALIQYTTNEEARRAISSTEAVLNNRFIRVLWHRE 76
penta_MxKDx super family cl11830
pentapeptide MXKDX repeat protein; Members of this protein family are small bacterial proteins, ...
 501-552 3.14e-03

pentapeptide MXKDX repeat protein; Members of this protein family are small bacterial proteins, each with an N-terminal signal sequence followed by up to 11 imperfect repeats of a pentapeptide. The pentapeptide repeat usually follows the form Met-Xaa-Lys-Asp-Xaa.


The actual alignment was detected with superfamily member TIGR02953:

Pssm-ID: 131998 [Multi-domain]  Cd Length: 75  Bit Score: 37.52  E-value: 3.14e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1908918739  501 DRAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEA 552
Cdd:TIGR02953   23 DAMKKDTMKKDAMGKDAMAKDAMSKDAMKKDAMKKDAMKKDGMKKDAMKKDA 74
 
Name Accession Description Interval E-value
DUF4795 pfam16043
Domain of unknown function (DUF4795); This family of proteins is functionally uncharacterized. ...
 729-919 3.70e-53

Domain of unknown function (DUF4795); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 285 and 978 amino acids in length.


Pssm-ID: 464990 [Multi-domain]  Cd Length: 181  Bit Score: 184.04  E-value: 3.70e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  729 TTVDILQKKIGSLQksrlkeEELERIWGNQIEMMKDryitldkavenLQIRMDEFKTLQAQIKRLEMNKVNKSTMEEELR 808
Cdd:pfam16043    7 ELLDQLQALILDLQ------EELEKLSETTSELSER-----------LQQRQKHLEALYQQIEKLEKVKADKEVVEEELD 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  809 EKADRSALAGKASRVDLETVALELNEMIQGILFKVTIHEDSWKKAMEELSKDVNTKLVHSDLDPLKKEMEEVWKIVRKLL 888
Cdd:pfam16043   70 EKADKEALASKVSRDQFDETLEELNQMLQELLDKLEGQEDAWKKALETLSEELDTKLDRLELDPLKELLERRIKALQKLL 149

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1908918739  889 IEGLRLDPD-SAAGFRRKLFKRVKCISCDRPV 919
Cdd:pfam16043  150 QEGSEELDEaEAAGFRKKLLERFHCISCDRPV 181
PHA03247 PHA03247
large tegument protein UL36; Provisional
 286-436 7.24e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 7.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  286 PELLPEGSSAQAVSLSRaQEPAQPPALTP--ESAPGCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGPSVTPGSL 363
Cdd:PHA03247  2848 PSLPLGGSVAPGGDVRR-RPPSRSPAAKPaaPARPPVRRLARPAVSRSTESFA--------LPPDQPERPPQPQAPPPPQ 2918

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  364 PAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRvGSWPLWDLGVLRP----------TQPQPSR---APPPATEF 430
Cdd:PHA03247  2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS-GAVPQPWLGALVPgrvavprfrvPQPAPSReapASSTPPLT 2997


                   ....*.
gi 1908918739  431 GSLWPR 436
Cdd:PHA03247  2998 GHSLSR 3003
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 283-427 3.50e-07

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 52.68  E-value: 3.50e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  283 YEVPELLPEGSSAQ--AVSLSRAQEPAQ-----PPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLeLEPVPALGPVPG 355
Cdd:pfam15822    1 FSLADALPEQSPAKtsAVSNPKPGQPPQgwpgsNPWNNPSAPPAVPSGLPPSTAPSTVPFGPAPTGM-YPSIPLTGPSPG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  356 P---------SVTPGSLPAPWPVL-GPVPaPGAQPPPLGDWPALPRRW--------PLPQG-WPRVGSWPlWDLGV---- 412
Cdd:pfam15822   80 PpapfppsgpSCPPPGGPYPAPTVpGPGP-IGPYPTPNMPFPELPRPYgaptdpaaAAPSGpWGSMSSGP-WAPGMggqy 157

                          170
                   ....*....|....*
gi 1908918739  413 LRPTQPQPSRAPPPA 427
Cdd:pfam15822  158 PAPNMPYPSPGPYPA 172
RRM_RBM27 cd12517
RNA recognition motif (RRM) found in vertebrate RNA-binding protein 27 (RBM27); This subgroup ...
 248-284 5.76e-04

RNA recognition motif (RRM) found in vertebrate RNA-binding protein 27 (RBM27); This subgroup corresponds to the RRM of RBM27 which contains a single RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain). Although the specific function of the RRM in RBM27 remains unclear, it shows high sequence similarity with RRM1of RBM26, which functions as a cutaneous lymphoma (CL)-associated antigen.


Pssm-ID: 409939 [Multi-domain]  Cd Length: 76  Bit Score: 39.65  E-value: 5.76e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1908918739  248 PEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYE 284
Cdd:cd12517     40 PEAALIQYTTNEEARRAISSTEAVLNNRFIRVLWHRE 76
penta_MxKDx TIGR02953
pentapeptide MXKDX repeat protein; Members of this protein family are small bacterial proteins, ...
 501-552 3.14e-03

pentapeptide MXKDX repeat protein; Members of this protein family are small bacterial proteins, each with an N-terminal signal sequence followed by up to 11 imperfect repeats of a pentapeptide. The pentapeptide repeat usually follows the form Met-Xaa-Lys-Asp-Xaa.


Pssm-ID: 131998 [Multi-domain]  Cd Length: 75  Bit Score: 37.52  E-value: 3.14e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1908918739  501 DRAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEA 552
Cdd:TIGR02953   23 DAMKKDTMKKDAMGKDAMAKDAMSKDAMKKDAMKKDAMKKDGMKKDAMKKDA 74
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 245-562 3.20e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 41.59  E-value: 3.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  245 EQLPEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGctTEF 324
Cdd:COG5180    212 EEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATVDAQPEMRPPADAKERRRAAIGDTPAAEPPGLPVLEAG--SEP 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  325 APGPAPGTEPVPGLELGLELEPvPALGPV-PGPSVTPGSLPAPwpvLGPVPAPGAQPPPLGDWPALPRRWPLPQGwprvg 403
Cdd:COG5180    290 QSDAPEAETARPIDVKGVASAP-PATRPVrPPGGARDPGTPRP---GQPTERPAGVPEAASDAGQPPSAYPPAEE----- 360

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  404 swplwdlgvLRPTQPQPSRAPPPATEFGSLWP--RPLQPYQSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGA--- 478
Cdd:COG5180    361 ---------AVPGKPLEQGAPRPGSSGGDGAPfqPPNGAPQPGLGRRGAPGPPMGAGDLVQAALDGGGRETASLGGAagg 431

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  479 ----PKDRTRKDGVPKDRGGKDVDPKDRAHKDDVPKDRGGKDVD--PKDRAHKDDVPKDR-GGKDGDPKDRVGKDGAPKE 551
Cdd:COG5180    432 agqgPKADFVPGDAESVSGPAGLADQAGAAASTAMADFVAPVTDatPVDVADVLGVRPDAiLGGNVAPASGLDAETRIIE 511

                          330
                   ....*....|.
gi 1908918739  552 AQPKAPQSALH 562
Cdd:COG5180    512 AEGAPATEDFV 522
PRK01156 PRK01156
chromosome segregation protein; Provisional
 735-887 4.88e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.04  E-value: 4.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  735 QKKIGSLQKSRLKEEELERIWGNQIEMMKDRYITLDKAVENLQIRMDEFKTLQAQIKRLEMN-------------KVNK- 800
Cdd:PRK01156   196 NLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEiktaesdlsmeleKNNYy 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  801 STMEEELREKADRSALAGKASRVDLETVA---LELNEMIQGILFKVTIHEDSWKKAmEELSKDvntklvHSDLDPLKKEM 877
Cdd:PRK01156   276 KELEERHMKIINDPVYKNRNYINDYFKYKndiENKKQILSNIDAEINKYHAIIKKL-SVLQKD------YNDYIKKKSRY 348

                          170
                   ....*....|
gi 1908918739  878 EEVWKIVRKL 887
Cdd:PRK01156   349 DDLNNQILEL 358
 
Name Accession Description Interval E-value
DUF4795 pfam16043
Domain of unknown function (DUF4795); This family of proteins is functionally uncharacterized. ...
 729-919 3.70e-53

Domain of unknown function (DUF4795); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 285 and 978 amino acids in length.


Pssm-ID: 464990 [Multi-domain]  Cd Length: 181  Bit Score: 184.04  E-value: 3.70e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  729 TTVDILQKKIGSLQksrlkeEELERIWGNQIEMMKDryitldkavenLQIRMDEFKTLQAQIKRLEMNKVNKSTMEEELR 808
Cdd:pfam16043    7 ELLDQLQALILDLQ------EELEKLSETTSELSER-----------LQQRQKHLEALYQQIEKLEKVKADKEVVEEELD 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  809 EKADRSALAGKASRVDLETVALELNEMIQGILFKVTIHEDSWKKAMEELSKDVNTKLVHSDLDPLKKEMEEVWKIVRKLL 888
Cdd:pfam16043   70 EKADKEALASKVSRDQFDETLEELNQMLQELLDKLEGQEDAWKKALETLSEELDTKLDRLELDPLKELLERRIKALQKLL 149

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1908918739  889 IEGLRLDPD-SAAGFRRKLFKRVKCISCDRPV 919
Cdd:pfam16043  150 QEGSEELDEaEAAGFRKKLLERFHCISCDRPV 181
PHA03247 PHA03247
large tegument protein UL36; Provisional
 286-436 7.24e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 7.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  286 PELLPEGSSAQAVSLSRaQEPAQPPALTP--ESAPGCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGPSVTPGSL 363
Cdd:PHA03247  2848 PSLPLGGSVAPGGDVRR-RPPSRSPAAKPaaPARPPVRRLARPAVSRSTESFA--------LPPDQPERPPQPQAPPPPQ 2918

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  364 PAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRvGSWPLWDLGVLRP----------TQPQPSR---APPPATEF 430
Cdd:PHA03247  2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS-GAVPQPWLGALVPgrvavprfrvPQPAPSReapASSTPPLT 2997


                   ....*.
gi 1908918739  431 GSLWPR 436
Cdd:PHA03247  2998 GHSLSR 3003
PHA03247 PHA03247
large tegument protein UL36; Provisional
 290-444 6.54e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 6.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  290 PEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPV 369
Cdd:PHA03247  2766 PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  370 LGPVPAPGAQPPPLGDW------------PALP-----RRWPLPQGWPRVGSWPLWDLGVLRPTQPQ-PSRAPPPATEFG 431
Cdd:PHA03247  2846 PPPSLPLGGSVAPGGDVrrrppsrspaakPAAParppvRRLARPAVSRSTESFALPPDQPERPPQPQaPPPPQPQPQPPP 2925

                          170
                   ....*....|...
gi 1908918739  432 SLWPRPLQPYQSR 444
Cdd:PHA03247  2926 PPQPQPPPPPPPR 2938
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 293-478 1.30e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 56.15  E-value: 1.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  293 SSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPgslPAPWPVLGP 372
Cdd:PRK07764   617 APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPA---PAPAAPAAP 693

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  373 VPAPGAQPPPLGDWPALPRRWPLPQGWPRVGSWPLW------DLGVLRPTQPQPSRAPPPATEFGslwPRPLQPYQSRQG 446
Cdd:PRK07764   694 AGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASapspaaDDPVPLPPEPDDPPDPAGAPAQP---PPPPAPAPAAAP 770

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1908918739  447 EALQLAAVQVKGEENDVPSLRGLRERARKDGA 478
Cdd:PRK07764   771 AAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAE 802
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 301-399 2.62e-07

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 53.74  E-value: 2.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  301 SRAQEPAQ---PPALTPESAPGCTTEFAPG--PAPGTEPVPGLELGlelEPVPALGPVPGPS-VTPGSLPAPWPVLGPVP 374
Cdd:PHA03201     6 SRSPSPPRrpsPPRPTPPRSPDASPEETPPspPGPGAEPPPGRAAG---PAAPRRRPRGCPAgVTFSSSAPPRPPLGLDD 82

                           90       100
                   ....*....|....*....|....*
gi 1908918739  375 APGAQPPPLgDWPALPRRWPLPQGW 399
Cdd:PHA03201    83 APAATPPPL-DWTEFRRRFLVGDAW 106
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
285-487 2.63e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 54.88  E-value: 2.63e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  285 VPELLPEGSSAQAVSLSRAQ---EPAQPPALTPESAPGCTTEFAPGPAPgtEPVPGLELGLELEPVPALGPVPGPSVTPG 361
Cdd:PRK12323   382 VAQPAPAAAAPAAAAPAPAAppaAPAAAPAAAAAARAVAAAPARRSPAP--EALAAARQASARGPGGAPAPAPAPAAAPA 459

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  362 SLPAPwpvlgpvPAPGAQPPPLGDWPALPRRWPLPQGWPRVGSWPLWDLGVLRPTQPQPSR-APPPATEFGSLWPRPLQP 440
Cdd:PRK12323   460 AAARP-------AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQpDAAPAGWVAESIPDPATA 532

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1908918739  441 YQSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGAPKDRTRKDG 487
Cdd:PRK12323   533 DPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDG 579
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 283-427 3.50e-07

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 52.68  E-value: 3.50e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  283 YEVPELLPEGSSAQ--AVSLSRAQEPAQ-----PPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLeLEPVPALGPVPG 355
Cdd:pfam15822    1 FSLADALPEQSPAKtsAVSNPKPGQPPQgwpgsNPWNNPSAPPAVPSGLPPSTAPSTVPFGPAPTGM-YPSIPLTGPSPG 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  356 P---------SVTPGSLPAPWPVL-GPVPaPGAQPPPLGDWPALPRRW--------PLPQG-WPRVGSWPlWDLGV---- 412
Cdd:pfam15822   80 PpapfppsgpSCPPPGGPYPAPTVpGPGP-IGPYPTPNMPFPELPRPYgaptdpaaAAPSGpWGSMSSGP-WAPGMggqy 157

                          170
                   ....*....|....*
gi 1908918739  413 LRPTQPQPSRAPPPA 427
Cdd:pfam15822  158 PAPNMPYPSPGPYPA 172
PHA03378 PHA03378
EBNA-3B; Provisional
 286-422 5.15e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 54.30  E-value: 5.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  286 PELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGS-LP 364
Cdd:PHA03378   697 PPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGApTP 776

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1908918739  365 APWPVLGPVP------APGAQPPPLGDWPAL---PRRWPLPQGWPRVGSWPLWDLGVL--RPTQPQPSR 422
Cdd:PHA03378   777 QPPPQAPPAPqqrprgAPTPQPPPQAGPTSMqlmPRAAPGQQGPTKQILRQLLTGGVKrgRPSLKKPAA 845
PHA03378 PHA03378
EBNA-3B; Provisional
 288-467 6.15e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 53.92  E-value: 6.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  288 LLPEGSSAQAVSLSRAQEPAQPPALTPESAPgcttefAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPW 367
Cdd:PHA03378   685 LPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQ------RPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPA 758

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  368 PVLGPVPAPGAQPPPLGDWPAlPRRWPLPQGWPRVGswplwdlgvlrPTQPQPSRAPPPATEFGslwprPLQPYQSRQGE 447
Cdd:PHA03378   759 AAPGRARPPAAAPGAPTPQPP-PQAPPAPQQRPRGA-----------PTPQPPPQAGPTSMQLM-----PRAAPGQQGPT 821

                          170       180
                   ....*....|....*....|
gi 1908918739  448 ALQLAAVQVKGEENDVPSLR 467
Cdd:PHA03378   822 KQILRQLLTGGVKRGRPSLK 841
PHA03378 PHA03378
EBNA-3B; Provisional
 306-442 7.74e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 53.53  E-value: 7.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  306 PAQPPALTPESAPGCTTEFAPGPA------PGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQ 379
Cdd:PHA03378   651 PHQPPQVEITPYKPTWTQIGHIPYqpsptgANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAA 730

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1908918739  380 PPPLGDWPALPRRWPLPQGWPrvgswplwdlGVLRPTQPQPSRAPPPATEFGSlwPRPLQPYQ 442
Cdd:PHA03378   731 PGRARPPAAAPGRARPPAAAP----------GRARPPAAAPGRARPPAAAPGA--PTPQPPPQ 781
PHA03378 PHA03378
EBNA-3B; Provisional
 307-482 1.37e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 52.76  E-value: 1.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  307 AQPPALTPESAP-GCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPPPLGD 385
Cdd:PHA03378   667 TQIGHIPYQPSPtGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARP 746

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  386 WPALPRRWPLPQGWPRVGSWPLWDLGvlRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGeALQLAAVQVKGEENDVPS 465
Cdd:PHA03378   747 PAAAPGRARPPAAAPGRARPPAAAPG--APTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPT-SMQLMPRAAPGQQGPTKQ 823

                          170
                   ....*....|....*...
gi 1908918739  466 -LRGLRERARKDGAPKDR 482
Cdd:PHA03378   824 iLRQLLTGGVKRGRPSLK 841
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 249-463 3.84e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.14  E-value: 3.84e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  249 EAALAQTTKYLEatRAIQVSEPVQNPQllqtvwhyevpellPEGSSAQAVSLSRAQEPAQP-PALTPESAPGCTTEFAPG 327
Cdd:PRK07764   371 ERGLLARLERLE--RRLGVAGGAGAPA--------------AAAPSAAAAAPAAAPAPAAAaPAAAAAPAPAAAPQPAPA 434

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  328 PAPGTEPvPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPpplgdwpalprrWPLPQGWPRVgswpl 407
Cdd:PRK07764   435 PAPAPAP-PSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPA------------APAPAAAPAA----- 496

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1908918739  408 wdlgvlrPTQPQPSRAPPPATEFGSLWPRPLQ--PYQSRQGEALQLAAVQVKGEENDV 463
Cdd:PRK07764   497 -------PAAPAAPAGADDAATLRERWPEILAavPKRSRKTWAILLPEATVLGVRGDT 547
PHA03247 PHA03247
large tegument protein UL36; Provisional
 226-418 4.65e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 4.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  226 DAMFTSEIGSSPLDLWQSVEQLPEAALAQTTKYLEATRAIQVSEPVQNPQLlqtvwHYEV-------PELLPEGSSAQAV 298
Cdd:PHA03247   295 DGVWGAALAGAPLALPAPPDPPPPAPAGDAEEEDDEDGAMEVVSPLPRPRQ-----HYPLgfpkrrrPTWTPPSSLEDLS 369

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  299 SLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGlelglelEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPG- 377
Cdd:PHA03247   370 AGRHHPKRASLPTRKRRSARHAATPFARGPGGDDQTRPA-------APVPASVPTPAPTPVPASAPPPPATPLPSAEPGs 442

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1908918739  378 --AQPPPLGDWPALPRRWPLPQGWPRVGSWPLWDLGVLRPTQP 418
Cdd:PHA03247   443 ddGPAPPPERQPPAPATEPAPDDPDDATRKALDALRERRPPEP 485
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 292-434 5.32e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 50.48  E-value: 5.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  292 GSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPgtePVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLG 371
Cdd:PRK14951   367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAA---APAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPA 443

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1908918739  372 PVPAPGAQPPPLGDWPALPRRWPLPQGWPRvgswplwDLGVLRPTQPQPsrAPPPATEFGSLW 434
Cdd:PRK14951   444 AVALAPAPPAQAAPETVAIPVRVAPEPAVA-------SAAPAPAAAPAA--ARLTPTEEGDVW 497
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 290-447 1.06e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.60  E-value: 1.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  290 PEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLElglelEPVPALGPVPGPSVTPGSLPAPWPV 369
Cdd:PRK07764   632 AAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAP-----PPAPAPAAPAAPAGAAPAQPAPAPA 706

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1908918739  370 LGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRVGSWPLWDLGvLRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGE 447
Cdd:PRK07764   707 ATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDP-PDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEE 783
PHA03247 PHA03247
large tegument protein UL36; Provisional
 270-446 2.53e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  270 PVQNPQLLQTVWHYEVPeLLPEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPA 349
Cdd:PHA03247  2704 PPPTPEPAPHALVSATP-LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  350 LGPVPGPSVTPG--SLPAPWpvlGPVPAPGAQPPPLgdwPALPrrwplPQGWPRVGSWPlwdlgvlrPTQPQPSRAPPPa 427
Cdd:PHA03247  2783 LTRPAVASLSESreSLPSPW---DPADPPAAVLAPA---AALP-----PAASPAGPLPP--------PTSAQPTAPPPP- 2842

                          170
                   ....*....|....*....
gi 1908918739  428 tefgslwPRPLQPYQSRQG 446
Cdd:PHA03247  2843 -------PGPPPPSLPLGG 2854
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
248-446 2.83e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 48.33  E-value: 2.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  248 PEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEGSSAQAVSLSRAQEPAQPPALTPESApgcttefAPG 327
Cdd:PRK12323   392 PAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAA-------ARP 464

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  328 PAPGTEPVPGLELGLELEPVPALGPVPGPSVTPgslpaPW---PVLGPVPAPGAQPPPLGDWPAlprrwplpQGWPRVGS 404
Cdd:PRK12323   465 AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP-----PWeelPPEFASPAPAQPDAAPAGWVA--------ESIPDPAT 531

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1908918739  405 WPLWDLGVLRPTQPQPSRAPPPATEFGSLWPrPLQPYQSRQG 446
Cdd:PRK12323   532 ADPDDAFETLAPAPAAAPAPRAAAATEPVVA-PRPPRASASG 572
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
290-395 3.95e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.95  E-value: 3.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  290 PEGSSAQAVSLSRAQEPAQPPALTPESAP---GCTTEFA-PGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPA 365
Cdd:PRK12323   469 PRPVAAAAAAAPARAAPAAAPAPADDDPPpweELPPEFAsPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAA 548

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1908918739  366 PWPV--LGPVPAPGAQPPPL----------GDWPALPRRWPL 395
Cdd:PRK12323   549 PAPRaaAATEPVVAPRPPRAsasglpdmfdGDWPALAARLPV 590
PHA03247 PHA03247
large tegument protein UL36; Provisional
 296-427 5.73e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 5.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  296 QAVSLSRAQEPAQPP-ALTPESAP---GCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGPSVT-PGSLPAPWPVL 370
Cdd:PHA03247  2666 RARRLGRAAQASSPPqRPRRRAARptvGSLTSLADPPPPPPTPEP--------APHALVSATPLPPGPaAARQASPALPA 2737

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1908918739  371 GPVPAPGAQPPPLGDWPALPRRWPLPQGWPRvgSWPLWDlgvlrPTQPQPSRAPPPA 427
Cdd:PHA03247  2738 APAPPAVPAGPATPGGPARPARPPTTAGPPA--PAPPAA-----PAAGPPRRLTRPA 2787
PHA03247 PHA03247
large tegument protein UL36; Provisional
 301-445 9.34e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 9.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  301 SRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGPSVTPGSLPAPwpvlGPVPAPgaqP 380
Cdd:PHA03247  2584 SRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPP--------DTHAPDPPPPSPSPAANEPDPH----PPPTVP---P 2648

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  381 PPLGDWPALPRRWPL----------------PQGW------PRVGswPLWDLGVLRPTQPQPSRAPPPATefgSLWPRPL 438
Cdd:PHA03247  2649 PERPRDDPAPGRVSRprrarrlgraaqasspPQRPrrraarPTVG--SLTSLADPPPPPPTPEPAPHALV---SATPLPP 2723


                   ....*..
gi 1908918739  439 QPYQSRQ 445
Cdd:PHA03247  2724 GPAAARQ 2730
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 306-445 9.81e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 9.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  306 PAQPPALTPESA-----PGCTTEFAPGPAPGTEPVPglelgleLEPVPALGPVP----GPSVTPGSLPAPWPVLGPVPAP 376
Cdd:pfam03154  183 PPSPPPPGTTQAatagpTPSAPSVPPQGSPATSQPP-------NQTQSTAAPHTliqqTPTLHPQRLPSPHPPLQPMTQP 255

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1908918739  377 G--------AQPPPLGDWPALPRRWPLPQGwPRVGSWPLWDLGVLRPTQPQPSRAPPPatefgslwPRPLQPYQSRQ 445
Cdd:pfam03154  256 PppsqvspqPLPQPSLHGQMPPMPHSLQTG-PSHMQHPVPPQPFPLTPQSSQSQVPPG--------PSPAAPGQSQQ 323
DUF4813 pfam16072
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ...
 291-396 1.90e-04

Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.


Pssm-ID: 435117 [Multi-domain]  Cd Length: 288  Bit Score: 44.75  E-value: 1.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  291 EGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEP-VPGLELGlELEPVPALGPVPGPSVTPG--SLPAPW 367
Cdd:pfam16072  153 SAGSGTTVINAGGQQPAAPAAPAYPVAPAAYPAQAPAAAPAPAPgAPQTPLA-PLNPVAAAPAAAAGAAAAPvvAAAAPA 231

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1908918739  368 PVLGPVPAPGAqPPPLGDWPA------LPRRWPLP 396
Cdd:pfam16072  232 AAAPPPPAPAA-PPADAAPPApggiicVPVRVPEP 265
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 292-399 2.99e-04

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 44.15  E-value: 2.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  292 GSSAQAVSL---SRAQEPAQPPALTPESAPgctteFAPGPAPgtePVPGlelglelEPVPAlgPVPGPSVTPGSLPAPWP 368
Cdd:pfam07174   25 GASAVAVALpavAHADPEPAPPPPSTATAP-----PAPPPPP---PAPA-------APAPP--PPPAAPNAPNAPPPPAD 87

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1908918739  369 VLGPVPAPG--AQPPPLGDWPALPR-----------RWPLPQGW 399
Cdd:pfam07174   88 PNAPPPPPAdpNAPPPPAVDPNAPEpgridnavggfSYVVPAGW 131
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 292-498 3.27e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 3.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  292 GSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSV---TPGSLPAPWP 368
Cdd:PRK07764   591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVavpDASDGGDGWP 670

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  369 VLGPVPAPGAQPPPLGDWP-----------ALPRRWPLPQGWPRVGSWPLWdlgvlrPTQPQPSRAPPPATEFGSLWPRP 437
Cdd:PRK07764   671 AKAGGAAPAAPPPAPAPAApaapagaapaqPAPAPAATPPAGQADDPAAQP------PQAAQGASAPSPAADDPVPLPPE 744

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1908918739  438 LQPYQSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGAPKDRTRKDGVPKDRGGKDVD 498
Cdd:PRK07764   745 PDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVA 805
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 301-549 3.36e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 3.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  301 SRAQEPAQPPALTPESAPGCTTEFAPGPAP-GTEPVPGLELGLELEPVPALgpvPGPSVTPGSLPAPWPVLGPVPAPGAQ 379
Cdd:PHA03307    75 PGTEAPANESRSTPTWSLSTLAPASPAREGsPTPPGPSSPDPPPPTPPPAS---PPPSPAPDLSEMLRPVGSPGPPPAAS 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  380 PPPLGDWPALPRRwplpqgwprvGSWPLWDLGVLRPTQPQPSRAP--PPATEFGSLWPRPLQPYQSRQGEALQLAAVqvk 457
Cdd:PHA03307   152 PPAAGASPAAVAS----------DAASSRQAALPLSSPEETARAPssPPAEPPPSTPPAAASPRPPRRSSPISASAS--- 218

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  458 geenDVPSLRGLRERARKDGAPKDRTRKDGVPKDRGGKDVDPKDRAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRGGKDG 537
Cdd:PHA03307   219 ----SPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRER 294

                          250
                   ....*....|..
gi 1908918739  538 DPKDRVGKDGAP 549
Cdd:PHA03307   295 SPSPSPSSPGSG 306
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
285-429 3.55e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.84  E-value: 3.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  285 VPELLPEGSSAQAVSLSRAQEPAQPP-------ALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPS 357
Cdd:PRK07003   376 VAGAVPAPGARAAAAVGASAVPAVTAvtgaagaALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANA 455

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1908918739  358 VTPGSLPAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRVGSWPLWDLGVLRPTQPQPSRAPPPATE 429
Cdd:PRK07003   456 RASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAP 527
PHA03379 PHA03379
EBNA-3A; Provisional
 321-474 4.33e-04

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 44.66  E-value: 4.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  321 TTEFAPGPAPGTE----PVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPV---LGPVPAPGAQPPPLGDWPALP-RR 392
Cdd:PHA03379   404 ALEKASEPTYGTPrppvEKPRPEVPQSLETATSHGSAQVPEPPPVHDLEPGPLhdqHSMAPCPVAQLPPGPLQDLEPgDQ 483

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  393 WPLPQGWPRVGSWPLWDLG--VLRPTQPQPSRAP--PPATEF-----GSLWPRPLQPYQSRQGEALQLAAVQVKGEENdv 463
Cdd:PHA03379   484 LPGVVQDGRPACAPVPAPAgpIVRPWEASLSQVPgvAFAPVMpqpmpVEPVPVPTVALERPVCPAPPLIAMQGPGETS-- 561

                          170
                   ....*....|.
gi 1908918739  464 pSLRGLRERAR 474
Cdd:PHA03379   562 -GIVRVRERWR 571
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 274-428 5.39e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.37  E-value: 5.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  274 PQLLQTVWHYEVPELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPG-------LELGLELEP 346
Cdd:pfam03154  313 PSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPhlsgpspFQMNSNLPP 392

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  347 VPALGPVPGPSV--TPGSLPAP---WPVLGPVPAPGAQPPPLGDWPALP---RRWPLPQGWPRVGSWPLWDLGVLRPTQP 418
Cdd:pfam03154  393 PPALKPLSSLSThhPPSAHPPPlqlMPQSQQLPPPPAQPPVLTQSQSLPppaASHPPTSGLHQVPSQSPFPQHPFVPGGP 472

                          170
                   ....*....|...
gi 1908918739  419 Q---PSRAPPPAT 428
Cdd:pfam03154  473 PpitPPSGPPTST 485
RRM_RBM27 cd12517
RNA recognition motif (RRM) found in vertebrate RNA-binding protein 27 (RBM27); This subgroup ...
 248-284 5.76e-04

RNA recognition motif (RRM) found in vertebrate RNA-binding protein 27 (RBM27); This subgroup corresponds to the RRM of RBM27 which contains a single RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain). Although the specific function of the RRM in RBM27 remains unclear, it shows high sequence similarity with RRM1of RBM26, which functions as a cutaneous lymphoma (CL)-associated antigen.


Pssm-ID: 409939 [Multi-domain]  Cd Length: 76  Bit Score: 39.65  E-value: 5.76e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1908918739  248 PEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYE 284
Cdd:cd12517     40 PEAALIQYTTNEEARRAISSTEAVLNNRFIRVLWHRE 76
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 293-439 7.20e-04

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 41.56  E-value: 7.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  293 SSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLP-APWPVLG 371
Cdd:pfam15240   14 SSAQSSSEDVSQEDSPSLISEEEGQSQQGGQGPQGPPPGGFPPQPPASDDPPGPPPPGGPQQPPPQGGKQKPqGPPPQGG 93

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1908918739  372 PVPAPGAQ---PPPLGDWPALPRRWPLPQGWPRVGSWPLWDLG-VLRPTQPQPSR--APPPATEFGSLWPRPLQ 439
Cdd:pfam15240   94 PRPPPGKPqgpPPQGGNQQQGPPPPGKPQGPPPQGGGPPPQGGnQQGPPPPPPGNpqGPPQRPPQPGNPQGPPQ 167
RRM1_RBM26 cd12516
RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 26 (RBM26); This ...
 248-284 9.91e-04

RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 26 (RBM26); This subgroup corresponds to the RRM1 of RBM26, also known as cutaneous T-cell lymphoma (CTCL) tumor antigen se70-2, which represents a cutaneous lymphoma (CL)-associated antigen. It contains two RNA recognition motifs (RRMs), also known as RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). The RRMs may play some functional roles in RNA-binding or protein-protein interactions.


Pssm-ID: 409938 [Multi-domain]  Cd Length: 76  Bit Score: 38.84  E-value: 9.91e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1908918739  248 PEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYE 284
Cdd:cd12516     40 PEGALIQFATHEEAKRAISSTEAVLNNRFIKVYWHRE 76
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 309-440 1.52e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.78  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  309 PPALTPESAPGCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGPSVtPGSLPAPWPVLGPVPAPGAQPPPLGDWPA 388
Cdd:PRK14951   366 PAAAAEAAAPAEKKTPARPEAAAPAAAP--------VAQAAAAPAPAAAP-AAAASAPAAPPAAAPPAPVAAPAAAAPAA 436

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1908918739  389 LPRRWPLPQGWPRVGSWPL--WDLGVLRPTQPQPSRAPPPATEFGSLWPRPLQP 440
Cdd:PRK14951   437 APAAAPAAVALAPAPPAQAapETVAIPVRVAPEPAVASAAPAPAAAPAAARLTP 490
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
272-423 1.62e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.46  E-value: 1.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  272 QNPQLLQTVWHYEVPELLPEGSSAqavslSRAQEPAQP--PALT-PESAPGCTTEFAPGPAPGTEPVPglelglelEPVP 348
Cdd:PRK14971   346 KNKRLLVELTLIQLAQLTQKGDDA-----SGGRGPKQHikPVFTqPAAAPQPSAAAAASPSPSQSSAA--------AQPS 412

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1908918739  349 ALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRVGswplwdLGVLRPTQPQPSRA 423
Cdd:PRK14971   413 APQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLG------PSTLRPIQEKAEQA 481
PHA03247 PHA03247
large tegument protein UL36; Provisional
 346-682 2.98e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  346 PVPALGP-VPGPSVTPGSLPAPWPvlGPVPAPGAQPP------PLGDwPALPRRWPLPQGWPRVGSWPLWDlgvlrPTQP 418
Cdd:PHA03247  2483 PAEARFPfAAGAAPDPGGGGPPDP--DAPPAPSRLAPailpdePVGE-PVHPRMLTWIRGLEELASDDAGD-----PPPP 2554

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  419 QPSRAPPPATEFG----SLWPRPLQP----YQSRQGEALQLAAVQVKGEENDVPslrglRERARKDGAPKDRTRKDGVPK 490
Cdd:PHA03247  2555 LPPAAPPAAPDRSvpppRPAPRPSEPavtsRARRPDAPPQSARPRAPVDDRGDP-----RGPAPPSPLPPDTHAPDPPPP 2629

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  491 DRGGKDVDPKDRAHKDDVPKDRGGKDVDP-KDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKE-----------AQPKAPQ 558
Cdd:PHA03247  2630 SPSPAANEPDPHPPPTVPPPERPRDDPAPgRVSRPRRARRLGRAAQASSPPQRPRRRAARPTvgsltsladppPPPPTPE 2709

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  559 SALHRLKTTAAIAAAAAAAYAAATSSAAQAAKVAAKFVKDAPATKMAAIATDTAAAGPLGVFADVLGAGPSRGATESQIL 638
Cdd:PHA03247  2710 PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVA 2789

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 1908918739  639 GddseiyeiLSPSYSAASIGPDPALSQAMVATKQAMSPEDKKRA 682
Cdd:PHA03247  2790 S--------LSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825
penta_MxKDx TIGR02953
pentapeptide MXKDX repeat protein; Members of this protein family are small bacterial proteins, ...
 501-552 3.14e-03

pentapeptide MXKDX repeat protein; Members of this protein family are small bacterial proteins, each with an N-terminal signal sequence followed by up to 11 imperfect repeats of a pentapeptide. The pentapeptide repeat usually follows the form Met-Xaa-Lys-Asp-Xaa.


Pssm-ID: 131998 [Multi-domain]  Cd Length: 75  Bit Score: 37.52  E-value: 3.14e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1908918739  501 DRAHKDDVPKDRGGKDVDPKDRAHKDDVPKDRGGKDGDPKDRVGKDGAPKEA 552
Cdd:TIGR02953   23 DAMKKDTMKKDAMGKDAMAKDAMSKDAMKKDAMKKDAMKKDGMKKDAMKKDA 74
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 245-562 3.20e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 41.59  E-value: 3.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  245 EQLPEAALAQTTKYLEATRAIQVSEPVQNPQLLQTVWHYEVPELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGctTEF 324
Cdd:COG5180    212 EEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATVDAQPEMRPPADAKERRRAAIGDTPAAEPPGLPVLEAG--SEP 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  325 APGPAPGTEPVPGLELGLELEPvPALGPV-PGPSVTPGSLPAPwpvLGPVPAPGAQPPPLGDWPALPRRWPLPQGwprvg 403
Cdd:COG5180    290 QSDAPEAETARPIDVKGVASAP-PATRPVrPPGGARDPGTPRP---GQPTERPAGVPEAASDAGQPPSAYPPAEE----- 360

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  404 swplwdlgvLRPTQPQPSRAPPPATEFGSLWP--RPLQPYQSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGA--- 478
Cdd:COG5180    361 ---------AVPGKPLEQGAPRPGSSGGDGAPfqPPNGAPQPGLGRRGAPGPPMGAGDLVQAALDGGGRETASLGGAagg 431

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  479 ----PKDRTRKDGVPKDRGGKDVDPKDRAHKDDVPKDRGGKDVD--PKDRAHKDDVPKDR-GGKDGDPKDRVGKDGAPKE 551
Cdd:COG5180    432 agqgPKADFVPGDAESVSGPAGLADQAGAAASTAMADFVAPVTDatPVDVADVLGVRPDAiLGGNVAPASGLDAETRIIE 511

                          330
                   ....*....|.
gi 1908918739  552 AQPKAPQSALH 562
Cdd:COG5180    512 AEGAPATEDFV 522
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 332-385 3.88e-03

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 39.08  E-value: 3.88e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1908918739  332 TEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGaqPPPLGD 385
Cdd:PRK05641    33 TYEVEAKGLGIDLSAVQEQVPTPAPAPAPAVPSAPTPVAPAAPAPA--PASAGE 84
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 326-435 4.79e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 40.29  E-value: 4.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  326 PGPAPgtePVPglelglelePVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPPplgdwPALPRRWPLPQGWPRVGSW 405
Cdd:pfam07174   41 PEPAP---PPP---------STATAPPAPPPPPPAPAAPAPPPPPAAPNAPNAPPP-----PADPNAPPPPPADPNAPPP 103

                           90       100       110
                   ....*....|....*....|....*....|
gi 1908918739  406 PLWDlgvlrPTQPQPSRAPPPATEFGSLWP 435
Cdd:pfam07174  104 PAVD-----PNAPEPGRIDNAVGGFSYVVP 128
PRK01156 PRK01156
chromosome segregation protein; Provisional
 735-887 4.88e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 41.04  E-value: 4.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  735 QKKIGSLQKSRLKEEELERIWGNQIEMMKDRYITLDKAVENLQIRMDEFKTLQAQIKRLEMN-------------KVNK- 800
Cdd:PRK01156   196 NLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEiktaesdlsmeleKNNYy 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  801 STMEEELREKADRSALAGKASRVDLETVA---LELNEMIQGILFKVTIHEDSWKKAmEELSKDvntklvHSDLDPLKKEM 877
Cdd:PRK01156   276 KELEERHMKIINDPVYKNRNYINDYFKYKndiENKKQILSNIDAEINKYHAIIKKL-SVLQKD------YNDYIKKKSRY 348

                          170
                   ....*....|
gi 1908918739  878 EEVWKIVRKL 887
Cdd:PRK01156   349 DDLNNQILEL 358
penta_MxKDx TIGR02953
pentapeptide MXKDX repeat protein; Members of this protein family are small bacterial proteins, ...
 481-531 5.55e-03

pentapeptide MXKDX repeat protein; Members of this protein family are small bacterial proteins, each with an N-terminal signal sequence followed by up to 11 imperfect repeats of a pentapeptide. The pentapeptide repeat usually follows the form Met-Xaa-Lys-Asp-Xaa.


Pssm-ID: 131998 [Multi-domain]  Cd Length: 75  Bit Score: 36.75  E-value: 5.55e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1908918739  481 DRTRKDGVPKDRGGKDVDPKDRAHKDDVPKDRGGKDVDPKDRAHKDDVPKD 531
Cdd:TIGR02953   23 DAMKKDTMKKDAMGKDAMAKDAMSKDAMKKDAMKKDAMKKDGMKKDAMKKD 73
PHA03247 PHA03247
large tegument protein UL36; Provisional
 274-435 5.56e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 5.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  274 PQLLQTVWHYEVPELLPE---GSSAQAVSLSRAQEPAQP---PALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPV 347
Cdd:PHA03247  2889 PAVSRSTESFALPPDQPErppQPQAPPPPQPQPQPPPPPqpqPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  348 PALGPVPGPSVTPgslPAPwpvlgPVPAPGAQPPPLGDWPAlprrwplpqgwPRVGSWPLwDLGVLRPTqpqpsrAPPPA 427
Cdd:PHA03247  2969 PGRVAVPRFRVPQ---PAP-----SREAPASSTPPLTGHSL-----------SRVSSWAS-SLALHEET------DPPPV 3022


                   ....*...
gi 1908918739  428 TEFGSLWP 435
Cdd:PHA03247  3023 SLKQTLWP 3030
PRK11633 PRK11633
cell division protein DedD; Provisional
 286-379 5.90e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.60  E-value: 5.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  286 PELLPEGSSAQAVSLSRAQEPAQPPALTPESAPgCTTEFAPGPAPGTEPVPglelglelEPVPALGPVPGPSVTPGSLPA 365
Cdd:PRK11633    64 PTQPPEGAAEAVRAGDAAAPSLDPATVAPPNTP-VEPEPAPVEPPKPKPVE--------KPKPKPKPQQKVEAPPAPKPE 134

                           90
                   ....*....|....
gi 1908918739  366 PWPVLGPVPAPGAQ 379
Cdd:PRK11633   135 PKPVVEEKAAPTGK 148
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 272-440 6.24e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 6.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  272 QNPQLLQTVWHYEVPELLPEGSSAQAVSlsrAQEPAQPPALTPESAPGcTTEFAPGPAPGTEPVPGLELGLELEP----- 346
Cdd:pfam03154  169 TQPPVLQAQSGAASPPSPPPPGTTQAAT---AGPTPSAPSVPPQGSPA-TSQPPNQTQSTAAPHTLIQQTPTLHPqrlps 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  347 -----VPALGPVPGPSVTPGSLPAPW--PVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPRVGSWPLWDLGVLRPTQpQ 419
Cdd:pfam03154  245 phpplQPMTQPPPPSQVSPQPLPQPSlhGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQ-Q 323

                          170       180
                   ....*....|....*....|.
gi 1908918739  420 PSRAPPPATEFGSLWPRPLQP 440
Cdd:pfam03154  324 RIHTPPSQSQLQSQQPPREQP 344
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 325-509 7.50e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 7.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  325 APGPAPGTEPVPGLELGLELEPVPALGPVPGPSVTPGSLPAPWPVLGPVPAPGAQPPPlgdwpALPRRWPLPQGWPRVGS 404
Cdd:PRK07764   594 AAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPE-----HHPKHVAVPDASDGGDG 668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  405 WPLWdlgvlrPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGEALQLAAVQVKGEENDVPSLRglRERARKDGAPKDRTR 484
Cdd:PRK07764   669 WPAK------AGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAA--QGASAPSPAADDPVP 740

                          170       180
                   ....*....|....*....|....*
gi 1908918739  485 KDGVPKDRGGKDVDPKDRAHKDDVP 509
Cdd:PRK07764   741 LPPEPDDPPDPAGAPAQPPPPPAPA 765
PHA03378 PHA03378
EBNA-3B; Provisional
 286-484 8.46e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 8.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  286 PELLPEGSSAQAVSLSRAQEPAQPPALTPESAPGCTTEFAPG-PAPGTEPVPGLELG---LELEPVP---ALGPVPG--P 356
Cdd:PHA03378   576 PLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPEtSAPRQWPMPLRPIPmrpLRMQPITfnvLVFPTPHqpP 655

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  357 SVTPGSLPAPWPVLGPVPApgaQPPPLGDWPALPRRWPLpqgwprvgswplwdlGVLRPTQPQPSRAPPPATEFGSLWPR 436
Cdd:PHA03378   656 QVEITPYKPTWTQIGHIPY---QPSPTGANTMLPIQWAP---------------GTMQPPPRAPTPMRPPAAPPGRAQRP 717

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1908918739  437 PLQPYQSRQGEALQLAAVQVKGEENDVPSLRGLRERARKDGAPKDRTR 484
Cdd:PHA03378   718 AAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRAR 765
Drf_FH1 pfam06346
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ...
 286-431 8.61e-03

Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.


Pssm-ID: 461881 [Multi-domain]  Cd Length: 157  Bit Score: 38.31  E-value: 8.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  286 PELLPEGSSAQAVSLSRAQEPAQPPALtpesaPGCTTEFAPGPAPGTEPVPglelglELEPVPALGPVPGPSVTPGS--L 363
Cdd:pfam06346   25 PPLPGGGGPPPPPPLPGSAAIPPPPPL-----PGGTSIPPPPPLPGAASIP------PPPPLPGSTGIPPPPPLPGGagI 93

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1908918739  364 PAPWPVLGPVPAPGAQPPPLGDWPALPRRWPLPQGWPrvgswplwdlgvLRPTQPQPSRAPPPATEFG 431
Cdd:pfam06346   94 PPPPPPLPGGAGVPPPPPPLPGGPGIPPPPPFPGGPG------------IPPPPPGMGMPPPPPFGFG 149
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 305-560 9.24e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 9.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  305 EPAQPPALTPESAPGCTTEFAPGPAPGTEPVPGLELGLELEPvpalGPVPGPSVTPGS----LPAPWPVLGPVPAPGAQP 380
Cdd:PHA03307   118 PPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASP----AAVASDAASSRQaalpLSSPEETARAPSSPPAEP 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  381 PPLGDWPALPRRWPLPQGWPRVGSwplwdlGVLRPTQPQPSRAPPPATEFGSLWPRPLQPYQSRQGEALQLAAVQVkgee 460
Cdd:PHA03307   194 PPSTPPAAASPRPPRRSSPISASA------SSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPI---- 263

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908918739  461 nDVPSLRGLRERARKDGAPKDRTRKDGVPKDRGGKDVDPKDRAHKDDVPKDRGGKDVDPKD-----RAHKDDVPKDRGGK 535
Cdd:PHA03307   264 -TLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSREsssssTSSSSESSRGAAVS 342

                          250       260
                   ....*....|....*....|....*
gi 1908918739  536 DGDPKDRVGKDGAPKEAQPKAPQSA 560
Cdd:PHA03307   343 PGPSPSRSPSPSRPPPPADPSSPRK 367
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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