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Conserved domains on  [gi|1908122456|ref|NP_001374059|]
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solute carrier family 41 member 2 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 200-334 7.54e-19

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


:

Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 82.49  E-value: 7.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122456 200 VPALLGLKGNLEMTLASRLSTAVNIGKMDsPIEKWNLIIGNLALKQVQATVVGFLAAVAAIILgwipegKYYLDHSILLC 279
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW------FGGLLLGLVVG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1908122456 280 SSSVATAFIASLLqGIIMVgviVGSKKTGINPDNVATPIAASFGDLITLAILAWI 334
Cdd:pfam01769  74 LALLLAVLIALLL-GTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 414-515 5.22e-10

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


:

Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 57.07  E-value: 5.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122456 414 TPVINGIGGNLVAIQASRISTYLHLHSIpgelpdEPKgcyyPFRTFFGPGVNNKSAQVLLLLVIPGHLIFLYTIHLMKSG 493
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEI------EPR----DAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGLLLGL 70

                          90       100
                  ....*....|....*....|....
gi 1908122456 494 HTSLTIIFIVV--YLFGAVLQIGM 515
Cdd:pfam01769  71 VVGLALLLAVLiaLLLGTLLPLLL 94
 
Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 200-334 7.54e-19

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 82.49  E-value: 7.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122456 200 VPALLGLKGNLEMTLASRLSTAVNIGKMDsPIEKWNLIIGNLALKQVQATVVGFLAAVAAIILgwipegKYYLDHSILLC 279
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW------FGGLLLGLVVG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1908122456 280 SSSVATAFIASLLqGIIMVgviVGSKKTGINPDNVATPIAASFGDLITLAILAWI 334
Cdd:pfam01769  74 LALLLAVLIALLL-GTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
160-331 3.96e-14

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 70.66  E-value: 3.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122456 160 ALQILVPFLLAGFGtvsAGMVLDIVQhwEVFRKVTEVFILVPALLGLKGNLEMTLASRLSTAVNIG----KMDSPIEKWN 235
Cdd:COG1824    14 SLPVLLVLAVGGII---AGLVLEGME--ELLLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHLGllepRLRPDRRLLN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122456 236 LIIGNLALKQVQATVVGFLAAVAAIILGWIPEGKYYLdhsillcsssVATAFIASLLQGIIM----VGVIVGSKKTGINP 311
Cdd:COG1824    89 NILATLILALLISPLIGVLAWLVAVLLGRGSLGLLTL----------VGIALLAGLLLALLLivvtYYVAIASYRFGLDP 158

                         170       180
                  ....*....|....*....|
gi 1908122456 312 DNVATPIAASFGDLITLAIL 331
Cdd:COG1824   159 DNVVIPVVTTLGDVFGVLFL 178
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 414-515 5.22e-10

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 57.07  E-value: 5.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122456 414 TPVINGIGGNLVAIQASRISTYLHLHSIpgelpdEPKgcyyPFRTFFGPGVNNKSAQVLLLLVIPGHLIFLYTIHLMKSG 493
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEI------EPR----DAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGLLLGL 70

                          90       100
                  ....*....|....*....|....
gi 1908122456 494 HTSLTIIFIVV--YLFGAVLQIGM 515
Cdd:pfam01769  71 VVGLALLLAVLiaLLLGTLLPLLL 94
 
Name Accession Description Interval E-value
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 200-334 7.54e-19

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 82.49  E-value: 7.54e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122456 200 VPALLGLKGNLEMTLASRLSTAVNIGKMDsPIEKWNLIIGNLALKQVQATVVGFLAAVAAIILgwipegKYYLDHSILLC 279
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEIE-PRDAWRVLLKELLVGLLLGLVLGLIAGVLAFLW------FGGLLLGLVVG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1908122456 280 SSSVATAFIASLLqGIIMVgviVGSKKTGINPDNVATPIAASFGDLITLAILAWI 334
Cdd:pfam01769  74 LALLLAVLIALLL-GTLLP---LLLWRLGLDPDNASGPLITTLGDLLGLLILFGI 124
MgtE2 COG1824
Permease, similar to cation transporters [Inorganic ion transport and metabolism];
160-331 3.96e-14

Permease, similar to cation transporters [Inorganic ion transport and metabolism];


Pssm-ID: 441429  Cd Length: 188  Bit Score: 70.66  E-value: 3.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122456 160 ALQILVPFLLAGFGtvsAGMVLDIVQhwEVFRKVTEVFILVPALLGLKGNLEMTLASRLSTAVNIG----KMDSPIEKWN 235
Cdd:COG1824    14 SLPVLLVLAVGGII---AGLVLEGME--ELLLAYPGLLVLVPAFLGTRGNLGGILGARLSTALHLGllepRLRPDRRLLN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122456 236 LIIGNLALKQVQATVVGFLAAVAAIILGWIPEGKYYLdhsillcsssVATAFIASLLQGIIM----VGVIVGSKKTGINP 311
Cdd:COG1824    89 NILATLILALLISPLIGVLAWLVAVLLGRGSLGLLTL----------VGIALLAGLLLALLLivvtYYVAIASYRFGLDP 158

                         170       180
                  ....*....|....*....|
gi 1908122456 312 DNVATPIAASFGDLITLAIL 331
Cdd:COG1824   159 DNVVIPVVTTLGDVFGVLFL 178
MgtE pfam01769
Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE ...
 414-515 5.22e-10

Divalent cation transporter; This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)


Pssm-ID: 460317 [Multi-domain]  Cd Length: 124  Bit Score: 57.07  E-value: 5.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1908122456 414 TPVINGIGGNLVAIQASRISTYLHLHSIpgelpdEPKgcyyPFRTFFGPGVNNKSAQVLLLLVIPGHLIFLYTIHLMKSG 493
Cdd:pfam01769   1 IPVILGLGGNLGSQSASRLSRALALGEI------EPR----DAWRVLLKELLVGLLLGLVLGLIAGVLAFLWFGGLLLGL 70

                          90       100
                  ....*....|....*....|....
gi 1908122456 494 HTSLTIIFIVV--YLFGAVLQIGM 515
Cdd:pfam01769  71 VVGLALLLAVLiaLLLGTLLPLLL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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