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Conserved domains on  [gi|1907002501|ref|NP_001373970|]
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heparan sulfate glucosamine 3-O-sulfotransferase 5 [Homo sapiens]

Protein Classification

sulfotransferase family protein( domain architecture ID 229543)

sulfotransferase family protein may utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to its substrate(s)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 super family cl21551
Sulfotransferase domain;
90-330 1.63e-31

Sulfotransferase domain;


The actual alignment was detected with superfamily member pfam00685:

Pssm-ID: 473908 [Multi-domain]  Cd Length: 253  Bit Score: 118.98  E-value: 1.63e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907002501  90 LPKAIIIGVRKGGTRALLEMLNLHPAV--VKASQEIHFFDNdENYGKGIEWYRKKMPF---SYPQQITIEKSPAYFITEE 164
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRgdFEKSEEPHLFNN-HNRSPFLEWYPGDTYFdvaEGPVRLNALPSPRIIKTHL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907002501 165 VPERIYK--MNSSIKLLIIVREPTTRAISDYTQVLEGKERKNKTYYKFEklaidpntcEVNTKYKAVRTSIYTKHLERWL 242
Cdd:pfam00685  80 PLHLLPKslWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEF---------VEDFLNGKVNCGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907002501 243 KYFPIEQFHVVDGDRLITEPLPELQLVEKFLNLPPRISQ-----YNLYFNATRGFYCLRFNII-------FNKCLAGSKg 310
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEEldkivKHLSFENMKGNPCLNYSKLpkevspfFRKGLVGDW- 229

                         250       260
                  ....*....|....*....|
gi 1907002501 311 riHPEVDPSVITKLRKFFHP 330
Cdd:pfam00685 230 --KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
90-330 1.63e-31

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 118.98  E-value: 1.63e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907002501  90 LPKAIIIGVRKGGTRALLEMLNLHPAV--VKASQEIHFFDNdENYGKGIEWYRKKMPF---SYPQQITIEKSPAYFITEE 164
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRgdFEKSEEPHLFNN-HNRSPFLEWYPGDTYFdvaEGPVRLNALPSPRIIKTHL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907002501 165 VPERIYK--MNSSIKLLIIVREPTTRAISDYTQVLEGKERKNKTYYKFEklaidpntcEVNTKYKAVRTSIYTKHLERWL 242
Cdd:pfam00685  80 PLHLLPKslWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEF---------VEDFLNGKVNCGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907002501 243 KYFPIEQFHVVDGDRLITEPLPELQLVEKFLNLPPRISQ-----YNLYFNATRGFYCLRFNII-------FNKCLAGSKg 310
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEEldkivKHLSFENMKGNPCLNYSKLpkevspfFRKGLVGDW- 229

                         250       260
                  ....*....|....*....|
gi 1907002501 311 riHPEVDPSVITKLRKFFHP 330
Cdd:pfam00685 230 --KNYFTPEQAEKFDEIYQE 247
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
90-330 1.63e-31

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 118.98  E-value: 1.63e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907002501  90 LPKAIIIGVRKGGTRALLEMLNLHPAV--VKASQEIHFFDNdENYGKGIEWYRKKMPF---SYPQQITIEKSPAYFITEE 164
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRgdFEKSEEPHLFNN-HNRSPFLEWYPGDTYFdvaEGPVRLNALPSPRIIKTHL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907002501 165 VPERIYK--MNSSIKLLIIVREPTTRAISDYTQVLEGKERKNKTYYKFEklaidpntcEVNTKYKAVRTSIYTKHLERWL 242
Cdd:pfam00685  80 PLHLLPKslWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEF---------VEDFLNGKVNCGSYFDHVKGWW 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907002501 243 KYFPIEQFHVVDGDRLITEPLPELQLVEKFLNLPPRISQ-----YNLYFNATRGFYCLRFNII-------FNKCLAGSKg 310
Cdd:pfam00685 151 KLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEEldkivKHLSFENMKGNPCLNYSKLpkevspfFRKGLVGDW- 229

                         250       260
                  ....*....|....*....|
gi 1907002501 311 riHPEVDPSVITKLRKFFHP 330
Cdd:pfam00685 230 --KNYFTPEQAEKFDEIYQE 247
Sulfotransfer_3 pfam13469
Sulfotransferase family;
94-276 4.91e-09

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 54.99  E-value: 4.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907002501  94 IIIGVRKGGTRALLEMLNLHPAVvkASQEIHFFDND------ENYGKGIEWYRKKMPFSypqQITIEKSPAYFiteEVPE 167
Cdd:pfam13469   2 FIVGLPRSGTTLLHRLLAAHPDV--RPPEETWFVIPrilallQAWGKSLEALARVPSYA---RWLCDKSPSHL---FHLD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907002501 168 RIYKMNSSIKLLIIVREPTTRAISDYTQVLEGkerKNKTYYKFEKLAIDPNTCEVNTKYKAVRtsiytkhlERWLKYFPi 247
Cdd:pfam13469  74 LLLKAFPDAKFIHLHRDPVDTVISSYCSLFGF---TLSSYSTAFLRDIGLALARWSRAYERLM--------AARARVPP- 141

                         170       180
                  ....*....|....*....|....*....
gi 1907002501 248 EQFHVVDGDRLITEPLPELQLVEKFLNLP 276
Cdd:pfam13469 142 GRFLDVRYEDLVADPEGTLRRILEFLGLP 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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