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Conserved domains on  [gi|1895975946|ref|NP_001373424|]
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SAC3 domain-containing protein 1 [Danio rerio]

Protein Classification

SAC3/GANP family protein( domain architecture ID 11142302)

SAC3/GANP family protein is a component of a multi-protein complex, such as Arabidopsis thaliana SAC3 family protein C that is a possible component of the TREX-2 complex (transcription and export complex 2)

Gene Ontology:  GO:0032991

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
SAC3_GANP pfam03399
SAC3/GANP family; This family includes diverse proteins involved in large complexes. The ...
40-326 1.06e-110

SAC3/GANP family; This family includes diverse proteins involved in large complexes. The alignment contains one highly conserved negatively charged residue and one highly conserved positively charged residue that are probably important for the function of these proteins. The family includes the yeast nuclear export factor Sac3, and mammalian GANP/MCM3-associated proteins, which facilitate the nuclear localization of MCM3, a protein that associates with chromatin in the G1 phase of the cell-cycle.


:

Pssm-ID: 460911  Cd Length: 287  Bit Score: 324.86  E-value: 1.06e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946  40 MCPAYELRQREAQSRLHRFEMLPGTEqdrlPRADISRAVKEYSRPAAGKDSTRASDLRPPSVLLKTVSYLVDEVATSSTf 119
Cdd:pfam03399   1 MCPEFERVRREVQNDLHRFEKEDPDT----GKADPSKAVKEYSRSAAGQEEPLPSDLRPPPVLLKTLDYLLDEILDRED- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946 120 QPWTEVYSFVFDRLRSVRQDMIIQRVSGPDCVAVLEKSVRFLLYSSYRLCGQPLQlYDPRINDTHLQESLSWLLESY--- 196
Cdd:pfam03399  76 EPLPEVHDFIWDRTRSIRQDFTIQNLSGPEAVDCLERIVRFHILSLHRLCEEPVE-FDPQQNLEQLQKCLQSLLEIYddl 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946 197 --SEGKHQHQEEFQALALLYNLGSAQAVQHVLALPERIRSSLAVRLALEVSRAHMERNPVRLLRLAKKLDFMQVCAVHRH 274
Cdd:pfam03399 155 rgKGIPCPNEAEFRAYYLLLNLGDPDILREVQQLPSEIRKSPEVQFALKLRRALQNNNYVRFFRLVRQVSYLMACLLERH 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1895975946 275 LLPCRRDLLLLYSHGHSSRNYRYPLQRLAQLLCLK-EALAVELCTVYSVKVTG 326
Cdd:pfam03399 235 FNEVRRYALKALNRAYSSKNKPFPLSDLARLLGFDdEEEAIEFCEAYGLEVSD 287
 
Name Accession Description Interval E-value
SAC3_GANP pfam03399
SAC3/GANP family; This family includes diverse proteins involved in large complexes. The ...
40-326 1.06e-110

SAC3/GANP family; This family includes diverse proteins involved in large complexes. The alignment contains one highly conserved negatively charged residue and one highly conserved positively charged residue that are probably important for the function of these proteins. The family includes the yeast nuclear export factor Sac3, and mammalian GANP/MCM3-associated proteins, which facilitate the nuclear localization of MCM3, a protein that associates with chromatin in the G1 phase of the cell-cycle.


Pssm-ID: 460911  Cd Length: 287  Bit Score: 324.86  E-value: 1.06e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946  40 MCPAYELRQREAQSRLHRFEMLPGTEqdrlPRADISRAVKEYSRPAAGKDSTRASDLRPPSVLLKTVSYLVDEVATSSTf 119
Cdd:pfam03399   1 MCPEFERVRREVQNDLHRFEKEDPDT----GKADPSKAVKEYSRSAAGQEEPLPSDLRPPPVLLKTLDYLLDEILDRED- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946 120 QPWTEVYSFVFDRLRSVRQDMIIQRVSGPDCVAVLEKSVRFLLYSSYRLCGQPLQlYDPRINDTHLQESLSWLLESY--- 196
Cdd:pfam03399  76 EPLPEVHDFIWDRTRSIRQDFTIQNLSGPEAVDCLERIVRFHILSLHRLCEEPVE-FDPQQNLEQLQKCLQSLLEIYddl 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946 197 --SEGKHQHQEEFQALALLYNLGSAQAVQHVLALPERIRSSLAVRLALEVSRAHMERNPVRLLRLAKKLDFMQVCAVHRH 274
Cdd:pfam03399 155 rgKGIPCPNEAEFRAYYLLLNLGDPDILREVQQLPSEIRKSPEVQFALKLRRALQNNNYVRFFRLVRQVSYLMACLLERH 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1895975946 275 LLPCRRDLLLLYSHGHSSRNYRYPLQRLAQLLCLK-EALAVELCTVYSVKVTG 326
Cdd:pfam03399 235 FNEVRRYALKALNRAYSSKNKPFPLSDLARLLGFDdEEEAIEFCEAYGLEVSD 287
SAC3 COG5079
Nuclear protein export factor [Intracellular trafficking and secretion / Cell division and ...
15-347 2.02e-44

Nuclear protein export factor [Intracellular trafficking and secretion / Cell division and chromosome partitioning];


Pssm-ID: 227411 [Multi-domain]  Cd Length: 646  Bit Score: 162.02  E-value: 2.02e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946  15 RQKEQTGVIQDQ---KAEASVPHGSCMTMCPAYELRQREAQSRLHRFEMLPGTEQdrlprADISRAVKEYSRPAAGKDST 91
Cdd:COG5079    52 RAKERELLEAKSanaLPSAIVFVGTCMDMCPEFEREERVLQNDVSPYEANPNVKK-----ASRTLAVKAYHRPAAGKHPE 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946  92 RASDLRPPSVLLKTVSYLVDEVATSSTfqpwTEVYSFVFDRLRSVRQDMIIQRVSGPDCVAVLEKSVRFLLYSSYRLCGQ 171
Cdd:COG5079   127 LPSDVRPPEVLVKTIDYLVKLCAGDQL----IEMHRFVRDRTRAVRQDFTIQNEKGKDAVECHERIARFHILFLHLLHDH 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946 172 PlqLYDPRINDTHLQESLSWLLESY-----SEGKHQHQEEFQALALLYNLGSAQAVQHVLALPERIRSSLAVRLALEVSR 246
Cdd:COG5079   203 P--HFSKQQELEQLKKSLASLIELYddgraGKKECPNEAEFRAYAILASLGDPRYVAGIQGWPGGIFCDLPVQIALKLMQ 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946 247 -----AHMERNPV----------RLLRL--AKKLDFMQVCAVHRHLLPCRRDLLLLYSHGHSSRNYRYPLQRLAQLLCLK 309
Cdd:COG5079   281 laqsnNFRLLGRRnteacfnlytRFFKLiqSPSVQYLMGCLLEKHNISIRGGALKAMEKEIESAHKNIPFVDLSGILDFE 360
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1895975946 310 E-ALAVELCTVYSVKVTGD-------------CVNFSKSS-FTEAS-SADLQCR 347
Cdd:COG5079   361 EkGEGEEFCKYYGLEIRIEdsvklpivfmlsaCIDYKKPTaILCTLlESRLQAR 414
 
Name Accession Description Interval E-value
SAC3_GANP pfam03399
SAC3/GANP family; This family includes diverse proteins involved in large complexes. The ...
40-326 1.06e-110

SAC3/GANP family; This family includes diverse proteins involved in large complexes. The alignment contains one highly conserved negatively charged residue and one highly conserved positively charged residue that are probably important for the function of these proteins. The family includes the yeast nuclear export factor Sac3, and mammalian GANP/MCM3-associated proteins, which facilitate the nuclear localization of MCM3, a protein that associates with chromatin in the G1 phase of the cell-cycle.


Pssm-ID: 460911  Cd Length: 287  Bit Score: 324.86  E-value: 1.06e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946  40 MCPAYELRQREAQSRLHRFEMLPGTEqdrlPRADISRAVKEYSRPAAGKDSTRASDLRPPSVLLKTVSYLVDEVATSSTf 119
Cdd:pfam03399   1 MCPEFERVRREVQNDLHRFEKEDPDT----GKADPSKAVKEYSRSAAGQEEPLPSDLRPPPVLLKTLDYLLDEILDRED- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946 120 QPWTEVYSFVFDRLRSVRQDMIIQRVSGPDCVAVLEKSVRFLLYSSYRLCGQPLQlYDPRINDTHLQESLSWLLESY--- 196
Cdd:pfam03399  76 EPLPEVHDFIWDRTRSIRQDFTIQNLSGPEAVDCLERIVRFHILSLHRLCEEPVE-FDPQQNLEQLQKCLQSLLEIYddl 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946 197 --SEGKHQHQEEFQALALLYNLGSAQAVQHVLALPERIRSSLAVRLALEVSRAHMERNPVRLLRLAKKLDFMQVCAVHRH 274
Cdd:pfam03399 155 rgKGIPCPNEAEFRAYYLLLNLGDPDILREVQQLPSEIRKSPEVQFALKLRRALQNNNYVRFFRLVRQVSYLMACLLERH 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1895975946 275 LLPCRRDLLLLYSHGHSSRNYRYPLQRLAQLLCLK-EALAVELCTVYSVKVTG 326
Cdd:pfam03399 235 FNEVRRYALKALNRAYSSKNKPFPLSDLARLLGFDdEEEAIEFCEAYGLEVSD 287
SAC3 COG5079
Nuclear protein export factor [Intracellular trafficking and secretion / Cell division and ...
15-347 2.02e-44

Nuclear protein export factor [Intracellular trafficking and secretion / Cell division and chromosome partitioning];


Pssm-ID: 227411 [Multi-domain]  Cd Length: 646  Bit Score: 162.02  E-value: 2.02e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946  15 RQKEQTGVIQDQ---KAEASVPHGSCMTMCPAYELRQREAQSRLHRFEMLPGTEQdrlprADISRAVKEYSRPAAGKDST 91
Cdd:COG5079    52 RAKERELLEAKSanaLPSAIVFVGTCMDMCPEFEREERVLQNDVSPYEANPNVKK-----ASRTLAVKAYHRPAAGKHPE 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946  92 RASDLRPPSVLLKTVSYLVDEVATSSTfqpwTEVYSFVFDRLRSVRQDMIIQRVSGPDCVAVLEKSVRFLLYSSYRLCGQ 171
Cdd:COG5079   127 LPSDVRPPEVLVKTIDYLVKLCAGDQL----IEMHRFVRDRTRAVRQDFTIQNEKGKDAVECHERIARFHILFLHLLHDH 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946 172 PlqLYDPRINDTHLQESLSWLLESY-----SEGKHQHQEEFQALALLYNLGSAQAVQHVLALPERIRSSLAVRLALEVSR 246
Cdd:COG5079   203 P--HFSKQQELEQLKKSLASLIELYddgraGKKECPNEAEFRAYAILASLGDPRYVAGIQGWPGGIFCDLPVQIALKLMQ 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1895975946 247 -----AHMERNPV----------RLLRL--AKKLDFMQVCAVHRHLLPCRRDLLLLYSHGHSSRNYRYPLQRLAQLLCLK 309
Cdd:COG5079   281 laqsnNFRLLGRRnteacfnlytRFFKLiqSPSVQYLMGCLLEKHNISIRGGALKAMEKEIESAHKNIPFVDLSGILDFE 360
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1895975946 310 E-ALAVELCTVYSVKVTGD-------------CVNFSKSS-FTEAS-SADLQCR 347
Cdd:COG5079   361 EkGEGEEFCKYYGLEIRIEdsvklpivfmlsaCIDYKKPTaILCTLlESRLQAR 414
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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