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Conserved domains on  [gi|1894925283|ref|NP_001373366|]
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C-X-C chemokine receptor type 6 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11606905)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
32-299 5.46e-147

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


:

Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 415.32  E-value: 5.46e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15173     1 YFLPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAAHEWIFGTVMCKITNGLYTI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEA--IST 189
Cdd:cd15173    81 NLYSSMLILTCITVDRFIVIVQATKAHNCHAKKMRWGKVVCTLVWVISLLLSLPQFIYSEVRNLSSKICSMVYPPdaIEV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYT 269
Cdd:cd15173   161 VVNIIQMTVGFFLPLLAMIICYSVIIKTLLHAKGFQKHKSLKIIFVVVAVFILTQLPYNIMKLIRTLHIENTDSTNFKYA 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 1894925283 270 IMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15173   241 ILITEAIAYLHACLNPILYAFVGVKFRKNF 270
 
Name Accession Description Interval E-value
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
32-299 5.46e-147

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 415.32  E-value: 5.46e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15173     1 YFLPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAAHEWIFGTVMCKITNGLYTI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEA--IST 189
Cdd:cd15173    81 NLYSSMLILTCITVDRFIVIVQATKAHNCHAKKMRWGKVVCTLVWVISLLLSLPQFIYSEVRNLSSKICSMVYPPdaIEV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYT 269
Cdd:cd15173   161 VVNIIQMTVGFFLPLLAMIICYSVIIKTLLHAKGFQKHKSLKIIFVVVAVFILTQLPYNIMKLIRTLHIENTDSTNFKYA 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 1894925283 270 IMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15173   241 ILITEAIAYLHACLNPILYAFVGVKFRKNF 270
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
48-288 2.35e-51

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 170.94  E-value: 2.35e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  48 GNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWA--YAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTCIT 124
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLvyYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 125 VDRFIVVVKATKAYNQQAKRmtWGKVTSLLIWVISLLVSLPQIIYGNVF---NLDKLICGYHDEAISTVVLATQM---TL 198
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPR--RAKVLILVIWVLALLLSLPPLLFGWTLtvpEGNVTVCFIDFPEDLSKPVSYTLlisVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 199 GFFLPLLTMIVCYSVIIKTLLHA--------GGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYTI 270
Cdd:pfam00001 159 GFLLPLLVILVCYTLIIRTLRKSaskqksseRTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLDKAL 238
                         250
                  ....*....|....*...
gi 1894925283 271 MVTEAIAYLRACLNPVLY 288
Cdd:pfam00001 239 SVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
37-304 1.45e-37

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 137.22  E-value: 1.45e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVIsIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGI-HEWVFGQVMCKSLLGIYTINFYT 115
Cdd:PHA03087   46 VYSTIFFFGLVGNIIVIYV-LTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYIlFQWSFGEFACKIVSGLYYIGFYN 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRmtWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAISTVVLATQ 195
Cdd:PHA03087  125 SMNFITVMSVDRYIAIVHPVKSNKINTVK--YGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKTMNWKLF 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 196 MT-----LGFFLPLLTMIVCYSVIIKTL-LHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYY-----AMT 264
Cdd:PHA03087  203 INfeiniIGMLIPLTILLYCYSKILITLkGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFksgckAVK 282
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 265 SFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNFWKLVK 304
Cdd:PHA03087  283 YIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLK 322
 
Name Accession Description Interval E-value
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
32-299 5.46e-147

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 415.32  E-value: 5.46e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15173     1 YFLPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAAHEWIFGTVMCKITNGLYTI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEA--IST 189
Cdd:cd15173    81 NLYSSMLILTCITVDRFIVIVQATKAHNCHAKKMRWGKVVCTLVWVISLLLSLPQFIYSEVRNLSSKICSMVYPPdaIEV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYT 269
Cdd:cd15173   161 VVNIIQMTVGFFLPLLAMIICYSVIIKTLLHAKGFQKHKSLKIIFVVVAVFILTQLPYNIMKLIRTLHIENTDSTNFKYA 240
                         250       260       270
                  ....*....|....*....|....*....|
gi 1894925283 270 IMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15173   241 ILITEAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
32-299 5.66e-117

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 339.19  E-value: 5.66e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd14984     1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAADGWVFGSFLCKLVSALYTI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYnqQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNV-FNLDKLICGYHDEAIS-- 188
Cdd:cd14984    81 NFYSGILFLACISIDRYLAIVHAVSAL--RARTLLHGKLTCLGVWALALLLSLPEFIFSQVsEENGSSICSYDYPEDTat 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 ---TVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEY----- 260
Cdd:cd14984   159 twkTLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRARNHKKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQLLGiisrs 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 261 -YAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14984   239 cELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
33-298 1.07e-82

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 252.37  E-value: 1.07e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTIN 112
Cdd:cd15174     2 FLPPLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAASSGWVFGTFLCKVVNSMYKIN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDK-LICGY-----HDEA 186
Cdd:cd15174    82 FYSCMLLLTCISVDRYIAIVQATKAHNSKNKRLLYSKLVCFFVWLLSTILSLPEILFSQSKEEESvTTCTMvypsnESNR 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSThwEYYAMTSF 266
Cdd:cd15174   162 FKVAVLALKVTVGFFLPFVVMVICYTLIIHTLLQAKRFQKHKALKVIIAVVTVFVLSQLPYNSILLIKTI--NAYNITIT 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 267 HYTIM--------VTEAIAYLRACLNPVLYAFVSLKFRKN 298
Cdd:cd15174   240 DCATSqnldiagqVTQSIAFLHSCLNPFLYVFVGVRFRKD 279
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
32-298 9.75e-81

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 247.38  E-value: 9.75e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15177     1 VFQPCVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAETLQGWIFGNAMCKLIQGLYAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKL-ICG--YHDEAIS 188
Cdd:cd15177    81 NFYSGFLFLTCISVDRYVVIVRATSAHRLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELsSCRmiFPEVVSR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLAT---QMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRST----HWEYY 261
Cdd:cd15177   161 TVKGATaltQVVLGFAIPLIVMAVCYAAIGRTLLAARGWERHRALRVIAALVVAFVLFQLPYSVVLLLDTAdllaTLELS 240
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1894925283 262 AMTS--FHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKN 298
Cdd:cd15177   241 CSQSkrKDIALLVTSGLAYVRCCLNPLLYAFVGVRFRRD 279
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
32-299 4.86e-77

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 237.73  E-value: 4.86e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15172     1 VFVPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYEAHQWIFGNFSCKLLRGIYAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLD---KLICGYHDEAIS 188
Cdd:cd15172    81 NFYSGMLLLACISVDRYIAIVQATKSFRLRSRTLAYSKLICAAVWLLAILISLPTFIFSEVYDFGleeQYVCEPKYPKNS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 T------VVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHW---- 258
Cdd:cd15172   161 TaimwklLVLSLQVSLGFFIPLLVMIFCYSFIIKTLLQAQNSQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEAINLgeqq 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1894925283 259 EYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15172   241 SCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
32-298 1.49e-74

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 231.19  E-value: 1.49e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15175     1 WFLPAMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASAAKKWVFGEEMCKAVYCLYKM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLD-----KLICGYHDEA 186
Cdd:cd15175    81 SFFSGMLLLMCISIDRYFAIVQAASAHRHRSRAVFISKVSSLGVWVLAFILSIPELLYSGVNNNDgngtcSIFTNNKQTL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLAtQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTS- 265
Cdd:cd15175   161 SVKIQIS-QMVLGFLVPLVVMSFCYSVIIKTLLQARNFEKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSFKGNTTDc 239
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1894925283 266 -----FHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKN 298
Cdd:cd15175   240 dysknLDFALDVTYSLACFRCCLNPFLYAFIGVKFRND 277
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
38-299 2.23e-71

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 223.30  E-value: 2.23e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSM 117
Cdd:cd15178     7 YVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVVKGWIFGTFMCKLVSLLQEANFYSGI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 118 LILTCITVDRFIVVVKATKAYNQqaKRMtWGKVTSLLIWVISLLVSLPQIIYGNVF---NLDKLIC--GYHDEAISTVVL 192
Cdd:cd15178    87 LLLACISVDRYLAIVHATRALTQ--KRH-LVKFVCAGVWLLSLLLSLPALLNRDAFkppNSGRTVCyeNLGNESADKWRV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 193 ATQM---TLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFI----RSTHWEYYAMTS 265
Cdd:cd15178   164 VLRIlrhTLGFLLPLVVMLFCYGFTIKTLLQTRSFQKHRAMRVIFAVVLAFLLCWLPYNVTVLIdtlmRTKLITETCELR 243
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1894925283 266 FHY--TIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15178   244 NHVdvALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
32-296 3.72e-65

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 207.29  E-value: 3.72e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15176     1 LFLPVFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAVNGWVLGTAMCKITSALYTM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNVFNL-DKLIC-----GYHDE 185
Cdd:cd15176    81 NFSCGMQFLACISVDRYVAITKATSR--QFTGKHCW--IVCLCVWLLAILLSIPDLVFSTVRENsDRYRClpvfpPSLVT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTS 265
Cdd:cd15176   157 SAKATIQILEVLLGFVLPFLVMVFCYSRVARALSRTPNVKKSRALKVLLAVVGVFIVTQLPYNVVKFYRAIDVIYLLITD 236
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1894925283 266 ------FHYTIMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15176   237 csmsktLDIAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
33-299 1.14e-57

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 187.57  E-value: 1.14e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTIN 112
Cdd:cd15182     2 FLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYHSSGWIFGEILCKAVTSIFYIG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNV--FNLDKLICGYHDEAIsTV 190
Cdd:cd15182    82 FYSSILFLTLMTIDRYLAVVHPLSA--LRSRKLRYASLVSVAVWVISILASLPELILSTVmkSDEDGSLCEYSSIKW-KL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRS----THWEYYAMTSF 266
Cdd:cd15182   159 GYYYQQNLFFLIPLGIIVYCYVRILQTLMRTRTMRKHRTVKLIFVIVLVFFLSWAPYNIVIFLRSlkdlTIPICECSKQL 238
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1894925283 267 HYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15182   239 DYAFYICRNIAFSHCCLNPVFYVFVGVKFRNHL 271
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
32-298 7.00e-57

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 186.13  E-value: 7.00e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15179     1 IFLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAANWYFGNFLCKAVHVIYTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNL-DKLICG--YHDEAIS 188
Cdd:cd15179    81 NLYSSVLILAFISLDRYLAIVHATNS--QRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELdDRYICDriYPEDTFE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLATQM---TLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFN---------LMKFIR-S 255
Cdd:cd15179   159 LWVVAFRFqhiLVGLVLPGLVILTCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYigisidtfmLLEIIKqS 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1894925283 256 THWEyyamTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKN 298
Cdd:cd15179   239 CEME----QTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 277
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
33-297 1.17e-56

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 185.34  E-value: 1.17e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTIN 112
Cdd:cd15184     2 LLPPLYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNAMCKLLTGLYHIG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAYnqQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLD-KLICGYHDEAISTVV 191
Cdd:cd15184    82 FFSGIFFIILLTIDRYLAIVHAVFAL--KARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGsHYTCSPHFPPSQYQF 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 LATQMT-----LGFFLPLLTMIVCYSVIIKTLLHAGGFQK-HRSLKIIFLVMAVFLLTQMPFNLMKFIRsTHWEYYAMTS 265
Cdd:cd15184   160 WKNFQTlkmniLGLVLPLLVMIICYSGILKTLLRCRNEKKrHKAVRLIFTIMIVYFLFWAPYNIVLLLN-TFQEFFGLNN 238
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1894925283 266 FHYT------IMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15184   239 CSSSnrldqaMQVTETLGMTHCCINPVIYAFVGEKFRS 276
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
32-299 7.95e-56

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 183.35  E-value: 7.95e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15180     1 VFLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVHGWIFGTGLCKLAGAVFKI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQqaKRMTWGKVTSLLIWVISLLVSLPQIIYGNV---FNLDKLICgYHDEAIS 188
Cdd:cd15180    81 NFYCGIFLLACISFDRYLSIVHAVQMYSR--KKPMLVHLSCLIVWLFCLLLSIPDFIFLEAtkdPRQNKTEC-VHNFPQS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLATQMT-----LGFFLPLLTMIVCYSVIIKTLLHAG-GFQKHRSLKIIFLVMAVFLLTQMPFNLMkFIRSTHWEYYA 262
Cdd:cd15180   158 DTYWWLALRllyhiVGFLLPLAVMVYCYTSILLRLLRSSqGFQKQRAIRVIVAVVVVFFLCWTPYNIA-LLVDTLIDLSV 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1894925283 263 M-------TSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15180   237 LdrncgteSRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
32-299 2.88e-54

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 179.17  E-value: 2.88e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15181     1 VFIPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAGWVFGTFLCKLVGAIHKL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYnqQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNV---FNLDKLICGYHDEAI- 187
Cdd:cd15181    81 NFYCSSLLLACISVDRYLAIVHAIHSY--RHRRLRSVHLTCGSIWLVCFLLSLPNLVFLEVetsTNANRTSCSFHQYGIh 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 -STVVLATQM---TLGFFLPLLTMIVCYSVIIKTLLHAG-GFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRS------T 256
Cdd:cd15181   159 eSNWWLTSRFlyhVVGFFLPLLIMGYCYATIVVTLCQSSrRLQKQKAIRVAILVTLVFCLCWLPYNIVIFLDTlddlkaV 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1894925283 257 HWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15181   239 VKNCKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
32-299 1.50e-53

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 177.57  E-value: 1.50e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd14985     1 VVIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWAtyTANQYDWPFGAFLCKVSSYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKayNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVF---NLDKLICGYH--D 184
Cdd:cd14985    81 SVNMFASIFLLTCMSVDRYLAIVHPVA--SRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQaieNLNKTACIMLypH 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHA------GGFQKHRSLKIIFLVMAVFLLTQMPFNLMKF------ 252
Cdd:cd14985   159 EAWHFGLSLELNILGFVLPLLIILTCYFHIARSLRKRyertgkNGRKRRKSLKIIFALVVAFLVCWLPFHFFKFldflaq 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1894925283 253 ---IRSTHWEYYAMTSFHYTIMvteaIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14985   239 lgaIRPCFWELFLDLGLPIATC----LAFTNSCLNPFIYVFVDRRFRQKV 284
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
48-288 2.35e-51

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 170.94  E-value: 2.35e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  48 GNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWA--YAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTCIT 124
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLvyYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 125 VDRFIVVVKATKAYNQQAKRmtWGKVTSLLIWVISLLVSLPQIIYGNVF---NLDKLICGYHDEAISTVVLATQM---TL 198
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPR--RAKVLILVIWVLALLLSLPPLLFGWTLtvpEGNVTVCFIDFPEDLSKPVSYTLlisVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 199 GFFLPLLTMIVCYSVIIKTLLHA--------GGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYTI 270
Cdd:pfam00001 159 GFLLPLLVILVCYTLIIRTLRKSaskqksseRTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLDKAL 238
                         250
                  ....*....|....*...
gi 1894925283 271 MVTEAIAYLRACLNPVLY 288
Cdd:pfam00001 239 SVTLWLAYVNSCLNPIIY 256
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
33-297 4.85e-51

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 170.78  E-value: 4.85e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA-YAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15185     2 FLPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIhYVRWNNWVFGHGMCKLLSGFYYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYnqQAKRMTWGKVTSLLIWVISLLVSLPQ-IIYGNVFNLDKLICG----YHDEA 186
Cdd:cd15185    82 GLYSEIFFIILLTIDRYLAIVHAVFAL--RARTVTFGIITSIITWGLAVLAALPEfIFYETQELFEEFLCSplypEDTED 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMT-LGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMT- 264
Cdd:cd15185   160 SWKRFHALRMNiFGLALPLLIMVICYTGIIKTLLRCPSKKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIFFETDc 239
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1894925283 265 ----SFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15185   240 erskHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRK 276
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
32-299 9.76e-51

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 170.14  E-value: 9.76e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd14982     1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIyyYLNGGWWPFGDFLCRLTGLLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNqqAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKL--IC-GYHDEA 186
Cdd:cd14982    81 YINMYGSILFLTCISVDRYLAVVHPLKSRR--LRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNstTCfEFLSEW 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLAT--QMTLGFFLPLLTMIVCYSVIIKTLLH-----AGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWE 259
Cdd:cd14982   159 LASAAPIVliALVVGFLIPLLIILVCYSLIIRALRRrskqsQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVRL 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1894925283 260 Y-----YAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14982   239 SfiadcSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
32-299 3.35e-50

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 168.63  E-value: 3.35e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYA-GIHEWVFGQVMCKSLLGIYT 110
Cdd:cd14970     1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSyLLGYWPFGEVMCKIVLSVDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNV--FNLDKLICGYHDEAIS 188
Cdd:cd14970    81 YNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKA--KLVSLCVWALSLVLGLPVIIFARTlqEEGGTISCNLQWPDPP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLAT----QMTLGFFLPLLTMIVCYSVIIKTL------LHAGGFQKHRSLK----IIFLVMAVFLLTQMPFNLMKFIR 254
Cdd:cd14970   159 DYWGRVftiyTFVLGFAVPLLVITVCYSLIIRRLrssrnlSTSGAREKRRARRkvtrLVLVVVAVFVVCWLPFHVFQIVR 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1894925283 255 sTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14970   239 -LLIDPPETLTVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
32-297 1.91e-49

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 166.55  E-value: 1.91e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15186     1 IFLSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLINEWGLHNAMCKLTTAFFFI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKAtkAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNlDKLICGYHDE--AIST 189
Cdd:cd15186    81 GFFGGIFFITVISIDRYLAIVLA--ANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTKMKE-NECLGDYPEVlqEIWP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQM-TLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRS-THWEYY----AM 263
Cdd:cd15186   158 VLRNVELnFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETlKLYDFFpscdMK 237
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1894925283 264 TSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15186   238 KDLRLALSVTETIAFSHCCLNPLIYAFAGEKFRR 271
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
32-299 1.88e-47

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 161.83  E-value: 1.88e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA-YAGIH-EWVFGQVMCKSLLGIY 109
Cdd:cd15192     1 IMIPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAaYTAMEyHWPFGNFLCKIASALV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVF---NLDKLICGYH-DE 185
Cdd:cd15192    81 SFNLYASVFLLTCLSIDRYLAIVHPMKS--RLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFfieNTNITVCAFHyPS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMT---LGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRS-----LKIIFLVMAVFLLTQMPFNL-------- 249
Cdd:cd15192   159 QNSTLLVGLGLMknlLGFLIPFLIILTCYTLIGKALKKAYEIQRNKPrndeiFKMIMAVVLFFFFCWIPHQIftfldvli 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1894925283 250 -MKFIRSTHWEYYAMTSFHYTImvteAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15192   239 qLKVIQDCHIADIVDTAMPFTI----CIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
34-297 4.40e-47

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 160.42  E-value: 4.40e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA-YAGIHEWVFGQVMCKSLLGIYTIN 112
Cdd:cd15183     3 LPPLYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIdYKLKDDWIFGDAMCKFLSGFYYLG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAYnqQAKRMTWGKVTSLLIWVISLLVSLPQI-IYGNVFNLDKLICGYH--DEAIST 189
Cdd:cd15183    83 LYSEIFFIILLTIDRYLAIVHAVFAL--RARTVTFGIITSIITWALAILASMPCLyFFKSQWEFTHHTCSAHfpRKSLIR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTL---GFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRS------THwEY 260
Cdd:cd15183   161 WKRFQALKLnllGLILPLLVMIICYTGIINILLRRPNEKKAKAVRLIFVITLLFFLLWTPYNLAAFVSAfqdvlfTP-SC 239
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1894925283 261 YAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15183   240 EQSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFRK 276
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
32-296 1.08e-46

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 159.56  E-value: 1.08e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFY-HKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15188     1 VFLPVFYTLVFLLGLAGNLLLFVVLLLYvPKKKKMTEVYLLNLAVSDLLFLVTLPFWAMYVAWHWVFGSFLCKFVSTLYT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNVFNLDK--LIC----GYHD 184
Cdd:cd15188    81 INFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSL--LVLVAVWVLSIALSVPDMVFVQTHHTNNgvWVChadyGGHH 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRS---THWEYY 261
Cdd:cd15188   159 TIWKLVFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRPPGQGRALRFVAALVVVFFVLWFPYNLTLFLHSlqdLHVIGN 238
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1894925283 262 AMTSFH--YTIMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15188   239 CERSRHldYALQVTESLAFVHCCLNPLLYAFVSKRFR 275
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
33-297 4.56e-46

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 158.04  E-value: 4.56e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTIN 112
Cdd:cd15187     2 FLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLLDQWVFGNAMCKIVSGAYYIG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGY--HDEAISTV 190
Cdd:cd15187    82 FYSSMFFITLMSIDRYLAIVHAVYALKVRTASH--GTILSLALWLVAILASVPLLVFYQVASEDGRLQCIpfYPGQGNSW 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLATQM---TLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYY-----A 262
Cdd:cd15187   160 KVFTNFevnILGLLIPFSILIFCYHNILRNLRRCHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSLHIidgcqN 239
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1894925283 263 MTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15187   240 SQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKK 274
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
32-297 2.17e-43

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 151.06  E-value: 2.17e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGI--HEWVFGQVMCKSLLGIY 109
Cdd:cd15193     1 IYIPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTAlgGQWLFGEGLCKLSSFII 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNVFNLDklICGYHDEAIST 189
Cdd:cd15193    81 AVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCA--LITCCIIWAVSLVLGIPSLVYRNLINES--VCVEDSSSRFF 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMT-LGFFLPLLTMIVCYSVIIKTLL-HAGGFQK-----HRSLKIIFLVMAVFLLTQMPFNLMKFIRstHWEYYA 262
Cdd:cd15193   157 QGISLATLfLTFVLPLIVILFCYCSILVRLRrHFHGAKRtgrrrRNSLRIVFAIVTAFVLSWLPFNTLKAVR--LLLELG 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1894925283 263 MTSF--------HYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15193   235 GGVLpchttvaiRQGLTITACLAFVNSCVNPLIYSLLDRHFRR 277
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
36-292 4.68e-43

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 150.13  E-value: 4.68e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGIH-EWVFGQVMCKSLLGIYTINF 113
Cdd:cd00637     3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVgLLVIPFSLVSLLLgRWWFGDALCKLLGFLQSVSL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNVFNLDKLIC---GYHDEAISTV 190
Cdd:cd00637    83 LASILTLTAISVDRYLAIVHPLRYRRRFTRRRA--KLLIALIWLLSLLLALPPLLGWGVYDYGGYCCcclCWPDLTLSKA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGF---------------QKHRSLKIIFLVMAVFLLTQMPFNLMKFIRS 255
Cdd:cd00637   161 YTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRirssssnssrrrrrrRERKVTKTLLIVVVVFLLCWLPYFILLLLDV 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1894925283 256 THWEYYAMtsFHYTIMVTEAIAYLRACLNPVLYAFVS 292
Cdd:cd00637   241 FGPDPSPL--PRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
32-296 5.49e-43

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 150.16  E-value: 5.49e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15168     1 IFLPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIyyYANGDHWIFGDFMCKLVRFLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGY----HDE 185
Cdd:cd15168    81 YFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAV--AISVAVWILVLLQLLPILFFATTGRKNNRTTCYdttsPEE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMT-LGFFLPLLTMIVCYSVIIKTLLH-----AGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFI----RS 255
Cdd:cd15168   159 LNDYVIYSMVLTgLGFLLPLLIILACYGLIVRALIRklgegVTSALRRKSIRLVIIVLALFAVCFLPFHVTRTInlaaRL 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1894925283 256 THWEYYA--MTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15168   239 LSGTASCatLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFR 281
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
32-299 3.50e-41

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 145.44  E-value: 3.50e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLvFVC--TLPF-WAYAGIHEWVFGQVMCKSLLGI 108
Cdd:cd15203     1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDL-LLClvSLPFtLIYTLTKNWPFGSILCKLVPSL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINFYTSMLILTCITVDRFIVVVKATKayNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGY------ 182
Cdd:cd15203    80 QGVSIFVSTLTLTAIAIDRYQLIVYPTR--PRMSKRHAL--LIIALIWILSLLLSLPLAIFQELSDVPIEILPYcgyfct 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 183 -------HDEAISTVVLATQmtlgFFLPLLTMIVCYSVIIKTL-----LHAGGF------------QKHRSLKIIFLVMA 238
Cdd:cd15203   156 eswpsssSRLIYTISVLVLQ----FVIPLLIISFCYFRISLKLrkrvkKKRGKRtlssrrrrselrRKRRTNRLLIAMVV 231
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1894925283 239 VFLLTQMPFNLMKFIRSTHWEYYAMTSFHYTI-MVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15203   232 VFAVCWLPLNLFNLLRDFEPLPQIDGRHFYLIfLICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
32-299 4.97e-41

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 144.91  E-value: 4.97e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA-YAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15093     1 VLIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAaSNALRHWPFGSVLCRLVLSVDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNL--DKLICGYH----D 184
Cdd:cd15093    81 INMFTSIFCLTVMSVDRYLAVVHPIKS--ARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENqdGSSACNMQwpepA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTL----LHAGGFQKHRSLK----IIFLVMAVFLLTQMPF---NLMKFI 253
Cdd:cd15093   159 AAWSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVksagLRAGWQQRKRSERkvtrMVVMVVVVFVICWLPFyvlQLVNVF 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1894925283 254 RSTHWEYYAMTSFHYTIMVTeaiaYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15093   239 VQLPETPALVGVYHFVVILS----YANSCANPILYGFLSDNFKKSF 280
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
32-299 2.64e-40

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 142.69  E-value: 2.64e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA-YAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15973     1 VVIQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAaSAALQHWPFGSAMCRTVLSVDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDK--LICG--YHDEA 186
Cdd:cd15973    81 INMFTSVFCLTVLSVDRYIAVVHPLRA--ARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGqaVACNliWPHPA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMTLGFFLPLLTMIVCYSVIIKTL----LHAGGFQKHRSLK----IIFLVMAVFLLTQMPFNLMKFIRSTHW 258
Cdd:cd15973   159 WSAAFVIYTFLLGFLLPVLAIGLCYILIIGKMravaLKAGWQQRRKSEKkitrMVLMVVTVFVICWMPFYVVQLLNLFLP 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1894925283 259 EYYAmTSFHYTIMvteaIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15973   239 RLDA-TVNHASLI----LSYANSCANPILYGFLSDNFRRSF 274
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
33-299 3.80e-39

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 139.89  E-value: 3.80e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15191     2 AIPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWAtyYSYGYNWLFGSVMCKICGSLLT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkvTSLLIWVISLLVSLPQIIYGNVFNLDKL-----ICGYHDE 185
Cdd:cd15191    82 LNLFASIFFITCMSVDRYLAVVYPLRSQRRRSWQARL---VCLLVWVLACLSSLPTFYFRDTYYIEELgvnacIMAFPNE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQM---TLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRS-----LKIIFLVMAVFLLTQMPFNLMKFIRSTH 257
Cdd:cd15191   159 KYAQWSAGLALmknTLGFLIPLIVIATCYFGIGRHLLKTKGFGKNKQrrdkvLKMVAAVVLAFLICWFPFHVLTFLDALA 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1894925283 258 WEY-----YAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15191   239 RMGvinncWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
37-299 3.13e-38

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 137.63  E-value: 3.13e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKL--QSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIYTIN 112
Cdd:cd14976     6 VYMVVFTVGLLGNLLVLYLLKSNKKLrqQSESNKFVFNLALTDLIFVLTLPFWAveYALDFVWPFGTAMCKVVRYVTKLN 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAYnqQAKRMTWGKVTSLLIWVISLLVSLPQIIYG--NVFNLDKLICGYHDEAISTV 190
Cdd:cd14976    86 MYSSIFFLTALSVTRYIAVARALKHG--WIRKAFGAFATTIAIWAAAALAAIPEAIFStdTWSSVNHTLCLLRFPKNSSV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLA---------TQMTLGFFLPLLTMIVCYSVIIKTL---LHAGGFQKHRSLKIIFLVMAVFLLTQMPFN-------LMK 251
Cdd:cd14976   164 TRWynwlgmyqlQKVVLGFFLPLGIITLSYLLLLRFLqrkRGGSKRRKSRVTKSVFIVVLSFFICWLPNQalslwsaLIK 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1894925283 252 FIrSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14976   244 FD-DVPFSDAFFAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-297 1.03e-37

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 136.82  E-value: 1.03e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  28 QFSKVFLPCMYLVVFVCGLVGNSLVL-VISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA---YAGIHeWVFGQVMCK 103
Cdd:cd15190     7 KPSYALIPVIYMLVFVLGLSGNGLVLwTVFRSKRKRRRSADTFIANLALADLTFVVTLPLWAvytALGYH-WPFGSFLCK 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 104 SLLGIYTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKrmTWGKVTSLLIWVISLLVSLPQIIYGNVFNLD---KLIC 180
Cdd:cd15190    86 LSSYLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSR--TSGIVALGVIWLLAALLALPALILRTTSDLEgtnKVIC 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 181 gYHD---------EAISTVVLATQMT-LGFFLPLLTMIVCYSVIIKTLlhAGGFQKH---------RSLKIIFLVMAVFL 241
Cdd:cd15190   164 -DMDysgvvsnesEWAWIAGLGLSSTvLGFLLPFLIMLTCYFFIGRTV--ARHFSKLrrkedkkkrRLLKIIITLVVTFA 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1894925283 242 LTQMPFNLMKFIRSTHW----------EYYAMTSFHYTImvteAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15190   241 LCWLPFHLVKTLYALMYlgilpfscgfDLFLMNAHPYAT----CLAYVNSCLNPFLYAFFDPRFRQ 302
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
32-298 1.40e-37

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 135.75  E-value: 1.40e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAY--AGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15194     1 GFLPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDkeVVLGPWRSGSFLCKGSSYII 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAIST 189
Cdd:cd15194    81 SVNMYCSVFLLTCMSLDRYLAIVLPLVS--RKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCNEDAGTPS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTL--GFFLPLLTMIVCYSVIIKTL-LHAGGFQKH-----RSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYY 261
Cdd:cd15194   159 KVIFSLVSLivAFFLPLLSILTCYCTIIWKLcHHYQKSGKHqkklrKSIKIVFIVVAAFVFSWMPFNLFKALAIASGLQV 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1894925283 262 AMTSFHYTIM-----VTEAIAYLRACLNPVLYAFVSLKFRKN 298
Cdd:cd15194   239 EVTCLPYTLAqlgmeVSAPLAFANSCANPFIYYFFDRYIRRA 280
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
37-304 1.45e-37

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 137.22  E-value: 1.45e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVIsIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGI-HEWVFGQVMCKSLLGIYTINFYT 115
Cdd:PHA03087   46 VYSTIFFFGLVGNIIVIYV-LTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYIlFQWSFGEFACKIVSGLYYIGFYN 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRmtWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAISTVVLATQ 195
Cdd:PHA03087  125 SMNFITVMSVDRYIAIVHPVKSNKINTVK--YGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKTMNWKLF 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 196 MT-----LGFFLPLLTMIVCYSVIIKTL-LHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYY-----AMT 264
Cdd:PHA03087  203 INfeiniIGMLIPLTILLYCYSKILITLkGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFksgckAVK 282
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 265 SFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNFWKLVK 304
Cdd:PHA03087  283 YIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLK 322
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
38-299 6.50e-37

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 133.97  E-value: 6.50e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKlQSLTDVFLVNLPLADLVFVCTLPFWAY--AGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd14974     7 YALIFLLGLPGNGLVIWVAGFKMK-RTVNTVWFLNLALADFLFCLFLPFLIVyiAMGHHWPFGSVLCKLNSFVISLNMFA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNVFNLDK-----LICGYH---DEAI 187
Cdd:cd14974    86 SVFLLTAISLDRCLLVLHPVWAQNHRTVRLAS--VVCVGIWILALVLSVPYFVFRDTVTHHNgrscnLTCVEDydlRRSR 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 STVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRsTHWEYYAMTSFH 267
Cdd:cd14974   164 HKALTVIRFLCGFLLPLLIIAICYSVIAVKLRRKRLAKSSKPLRVLLAVVVAFFLCWLPYHVFALLE-LVAAAGLPEVVL 242
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1894925283 268 YTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14974   243 LGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
33-308 6.64e-37

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 135.03  E-value: 6.64e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFyHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTIN 112
Cdd:PHA02834   30 FVIVFYILLFIFGLIGNVLVIAVLIV-KRFMFVVDVYLFNIAMSDLMLVFSFPFIIHNDLNEWIFGEFMCKLVLGVYFVG 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAYNqqaKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKL----ICGYHDEAIS 188
Cdd:PHA02834  109 FFSNMFFVTLISIDRYILVVNATKIKN---KSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLkqciFNDYHENFSW 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLATQMTL-GFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTH------WEYY 261
Cdd:PHA02834  186 SAFFNFEINIfGIVIPLIILIYCYSKILYTLKNCKNKNKTRSIKIILTVVTFTVVFWVPFNIVLFINSLQsvglidIGCY 265
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1894925283 262 AMTSFHYTIMVTEAIAYLRACLNPVLYAFVSlkfrKNFWKLVKDIGC 308
Cdd:PHA02834  266 HFKKIVYSIDIAELISFVHCCVNPIIYAFVG----KNFKKVFKNMFC 308
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
33-299 6.30e-35

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 128.65  E-value: 6.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPF--WAYAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15375     2 YLPVMYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFliYYYINGESWIFGEFMCKFIRFIFH 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRmtWGKVTSLLIWVISLLVSLPQIIYGNVFNLD-KLIC---GYHDEA 186
Cdd:cd15375    82 FNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRR--WAIVACAVVWVISLAEVSPMTFLITTKEKNnRTICldfTSSDNL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMT-LGFFLPLLTMIVCYSVIIKTL---LHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYA 262
Cdd:cd15375   160 NTIWWYNWILTvLGFLLPLVIVTLCYTRIIYTLakgPHTGSASKQKARRLIILILLVFYVCFLPFHILRVVRIETRLPPV 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1894925283 263 ----MTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15375   240 scclKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
36-299 9.64e-35

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 127.68  E-value: 9.64e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGIHE-WVFGQVMCKSLLGIYTINF 113
Cdd:cd14967     4 VFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVaLLVMPFSAVYTLLGyWPFGPVLCRFWIALDVLCC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAISTVVLA 193
Cdd:cd14967    84 TASILNLCAISLDRYLAITRPLRYRQLMTKKRA--LIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKIYVL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 194 TQMTLGFFLPLLTMIVCYSVIIKTLLHaggfqKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMtsfHYTIMVT 273
Cdd:cd14967   162 VSSVISFFIPLLIMIVLYARIFRVARR-----ELKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPPDCVP---PILYAVF 233
                         250       260
                  ....*....|....*....|....*.
gi 1894925283 274 EAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14967   234 FWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
32-299 1.22e-34

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 128.04  E-value: 1.22e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHeWVFGQVMCKSLLGIY 109
Cdd:cd15971     1 AFLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAiqVALVH-WPFGKAICRVVMTVD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGNVFNLD-----KLICGYHD 184
Cdd:cd15971    80 GINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRT--AKMINMAVWGVSLLVILPIMIYAGVQTKHgrsscTIIWPGES 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTL----LHAGGFQKHRSLK----IIFLVMAVFLLTQMP---FNLMKFI 253
Cdd:cd15971   158 SAWYTGFIIYTFILGFFVPLTIICLCYLFIIIKVkssgIRVGSSKRKKSEKkvtrMVSIVVAVFVFCWLPfyiFNVSSVS 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1894925283 254 RSTHWEYYAMTSFHYTIMVTeaiaYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15971   238 VSISPTPGLKGMFDFVVVLS----YANSCANPILYAFLSDNFKKSF 279
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
34-297 3.59e-34

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 126.87  E-value: 3.59e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINF 113
Cdd:cd15171     3 VPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAWHGGSLGNPTCKVLVALSSVGL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAYNqQAKRMTWGKVTSLLIWVISLLVSLPQII-YGNVFNLDKLICGYH-------DE 185
Cdd:cd15171    83 HSEALFNVLLTVQASRVFFHGRLASS-ARRVAPCGIIASVLAWLTAFLVTLPEFVfYKPQMDSQKSKCAFSrphflpaEE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMT-LGFFLPLLTMIVCYSVIIKTLLHAGgfQKHRSLKIIFLVMAVFLLTQMPFNLMKFIrSTHWEYYAM- 263
Cdd:cd15171   162 TFWKYFLTLKMNiVVLVFPLLVFIICCVQLRKTQRFRE--RQRDLSKLVFAIMVVFLLMWAPYNIALFL-SAFKEHFSLr 238
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1894925283 264 ---TSFHY--TIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15171   239 dckSSYHLdaSVQVTKLIATTHCCVNPLLYALLDPAFRR 277
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
32-298 3.68e-34

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 126.80  E-value: 3.68e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15088     1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIhqFAIDGQWYFGEVMCKIITALD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNV--FNLDKLICGYHDEAI 187
Cdd:cd15088    81 ANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVA--KLVNVGLWAASFLSILPVWVYSSLiyFPDGTTFCYVSLPSP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 STVVLAT--QMTLGFFLPLLTMIVCYSVIIKTL--LHAGGFQKH------RSLKIIFLVMAVFLLTQMPFNLMKFIRSTH 257
Cdd:cd15088   159 DDLYWFTiyHFILGFAVPLVVITVCYILILHRLarGVAPGNQSHgssrtkRVTKMVILIVVVFIVCWLPFHVVQLVNLAM 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1894925283 258 weYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKN 298
Cdd:cd15088   239 --NRPTLAFEVAYFLSICLGYANSCLNPFVYILVSENFRKR 277
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
32-299 6.84e-34

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 125.79  E-value: 6.84e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFW-AYAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15970     1 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLvTSTLLRHWPFGSLLCRLVLSVDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVF-NLDKLI-CGYHDEAIS 188
Cdd:cd15970    81 INMFTSIYCLTVLSIDRYIAVVHPIKA--ARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTApNSDGSVaCNMQMPEPS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 T----VVLATQMTLGFFLPLLTMIVCYSVIIKTL----LHAGGFQKHRSLK----IIFLVMAVFLLTQMPFNLMKFIRST 256
Cdd:cd15970   159 QrwlaVFVVYTFLMGFLLPVIAICLCYILIIVKMrvvaLKAGWQQRKRSERkitlMVMMVVTVFVICWMPFYVVQLVSVF 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1894925283 257 HWEYYAMTSfhytiMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15970   239 VGQHDATVS-----QLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
37-297 1.56e-33

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 124.50  E-value: 1.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKlQSLTDVFLVNLPLADLVFVCTLPFwAYAGI---HEWVFGQVMCKSLLGIYTINF 113
Cdd:cd15115     6 VLSLTFLLGVPGNGLVIWVAGLKMK-RTVNTIWFLNLAVADLLCCLSLPF-SIAHLllnGHWPYGRFLCKLLPSIIVLNM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNVF-NLDKLICGYHDEAISTVvl 192
Cdd:cd15115    84 FASVFTLTAISLDRFLLVIKPVWAQNHRSVLLAC--LLCGCIWILALLLCLPVFIYRTTVtDGNHTRCGYDFLVAITI-- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 193 aTQMTLGFFLPLLTMIVCYSVIIKTLLHAGG-FQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYTiM 271
Cdd:cd15115   160 -TRAVFGFLLPLLIIAACYSFIAFRMQRGRFaKSQSKTFRVIIAVVVAFFVCWAPYHIIGILSLYGDPPLSKVLMSWD-H 237
                         250       260
                  ....*....|....*....|....*.
gi 1894925283 272 VTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15115   238 LSIALAYANSCLNPVLYVFMGKDFKK 263
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
32-299 2.16e-33

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 124.48  E-value: 2.16e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIH--EWVFGQVMCKSLLGIY 109
Cdd:cd15162     1 VFLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHgnNWIFGEALCRLVTVAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGkvTSLLIWVISLLVSLPQIIYGNVFNLDKL-ICGYHDeAIS 188
Cdd:cd15162    81 YGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALG--TCLAIWLLALLVTLPLYLVKQTIFLPALdITTCHD-VLP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLATQMT--------LGFFLPLLTMIVCYSVIIKTLL----HAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRST 256
Cdd:cd15162   158 EQLLVGDWFyyflslaiVGFLIPFILTASCYVATIRTLAaledENSEKKKKRAIKLAATVLAIFIICFAPSNLLLLAHYS 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1894925283 257 HWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15162   238 LISSSGTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFRDHV 280
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
32-299 2.36e-33

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 124.53  E-value: 2.36e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA-YAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15974     1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLAtQNAISYWPFGSFLCRLVMTVDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGNV---FNLDKLICGYHDEAI 187
Cdd:cd15974    81 VNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRV--AKLINATVWTLSFLVVLPVIIFSDVqpdLNTCNISWPEPVSVW 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 STVVLATQMTLGFFLPLLTMIVCYSVII----KTLLHAGGFQKHRSLK----IIFLVMAVFLLTQMPFNLMKFIRSTHW- 258
Cdd:cd15974   159 STAFIIYTAVLGFFGPLLVICLCYLLIVikvkSSGLRVGSTKRRKSERkvtrMVVIIVVVFVFCWLPFYMLNIVNLIVIl 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1894925283 259 -EYYAMTSFHYTIMVteaIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15974   239 pEEPAFVGVYFFVVV---LSYANSCANPILYGFLSDNFKQSF 277
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
32-299 7.67e-33

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 122.99  E-value: 7.67e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYA-GIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15972     1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQnALSYWPFGSFMCRLVMTVDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGNVfNLDKLICGYH----DEA 186
Cdd:cd15972    81 INQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPV--AKTVNATVWALSFLVVLPVVIFSGV-PGGMGTCHIAwpepAQV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAG-----GFQKHRS-----LKIIFLVMAVFLLTQMPFNLMKFIrST 256
Cdd:cd15972   158 WRAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGrrvraTSTKRRGserkvTRMVVIVVAAFVLCWLPFYALNIV-NL 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1894925283 257 HWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15972   237 VCPLPEEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
37-299 1.26e-32

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 122.72  E-value: 1.26e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIH-EWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15155     6 VYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNrHWPFGDSLCKISGTAFLTNIYG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICgyhdEAISTVVLATQ 195
Cdd:cd15155    86 SMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCF----EGFSKSIWKTY 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 196 MT--------LGFFLPLLTMIVCYSVIIKTL-----LHAGGFQKHRSLKIIFLVMAVFLLTQMPFN----LMKFIRSTHW 258
Cdd:cd15155   162 LSkitifievVGFIIPLLLNLTCSSLVLRTLrkpatLSQIGTNKEKVLKMILVHVAIFVVCFVPYNsilfLYALVRSQAI 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1894925283 259 EYYAMTSFHYTIM-VTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15155   242 ANCGVERFARTMYpITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
32-299 2.19e-32

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 121.74  E-value: 2.19e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15157     1 VIYPTVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRAdyYLMGSHWVFGDIACRIMSYSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYnqQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLIC-GYHDEAIS 188
Cdd:cd15157    81 YVNMYCSIYFLTVLSIVRFLAIVHPFKLW--KVTSIKYARILCAVIWIFVMAASSPLLSKGTSKYNSQTKClDLHPSKID 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLATQMTL--GFFLPLLTMIVCYSVIIKTLL-----HAGGFQKHR-SLKIIFLVMAVFLLTQMPFNLMKFIRSTHW-E 259
Cdd:cd15157   159 KLLILNYIVLvvGFILPFCTLSICYILIIKALLkprvpQSKLRVSHKkALLTIIITLILFLLCFLPYHILRTVHLMQWsE 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 260 YYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15157   239 GQCNLRLHKAVVITLCLAAANSCLDPLLYYFAGENFKERL 278
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
33-297 2.19e-32

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 122.33  E-value: 2.19e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPF--WAYAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15377     2 YLPAVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPAliFYYFNKTDWIFGDAMCKLQRFIFH 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIY-GNVFNLDKLICGYH---DEA 186
Cdd:cd15377    82 VNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNA--ICISVLVWLIVVVAISPILFYsGTGVRKNKTITCYDttsDEY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMT--LGFFLPLLTMIVCYSVIIKTLLHAGGFQ--------KHRSLKIIFLVMAVFLLTQMPFNLMKFIRST 256
Cdd:cd15377   160 LRSYFIYSMCTtvAMFCVPFILILGCYGLIVRALIYKDMKYteennaplRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLR 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1894925283 257 HWEYY---AMTSF----HYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15377   240 ARLDFqtpAMCAFndrvYATYQVTRGLASLNSCVDPILYFLAGDTFRR 287
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
32-299 3.90e-32

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 121.41  E-value: 3.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKlQSLTDVFLVNLPLADLVFVCTLPF-WAYAGI-HEWVFGQVMCKSLLGIY 109
Cdd:cd15116     1 ILSMVIYSVVFVLGVLGNGLVIFITGFKMK-KTVNTVWFLNLAVADFLFTFFLPFsIAYTAMdFHWPFGRFMCKLNSFLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIY---GNVFNLDKLIC------ 180
Cdd:cd15116    80 FLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRL--ASLVSLAVWVVAFFLSSPSFIFrdtAPSQNNNKIICfnnfsl 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 181 --GYHDEAIS-------TVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMK 251
Cdd:cd15116   158 sgDNSSPEVNqlrnmrhQVMTITRFLLGFLIPFTIIICCYAAIVLKLKRNRLAKSSKPFKIIAAVIVTFFLCWAPYHILN 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1894925283 252 FIrSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15116   238 LL-EMEATRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
32-299 4.38e-32

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 121.55  E-value: 4.38e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL--VFVCtLPFWAYAGIH-EWVFGQVMCKSLLGI 108
Cdd:cd14993     1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLlvSLFC-MPLTLLENVYrPWVFGEVLCKAVPYL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIY------GNVFNLDKLICGY 182
Cdd:cd14993    80 QGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRA--RIIIVAIWVIAIIIMLPLLVVyeleeiISSEPGTITIYIC 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 183 HDEAISTVV----LATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGF----------------QKHRSLKIIFLVMAVFLL 242
Cdd:cd14993   158 TEDWPSPELrkayNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPgdrgsanstssrrilrSKKKVARMLIVVVVLFAL 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1894925283 243 TQMPFNLMkFIRSthwEYYAMTSFH------YTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14993   238 SWLPYYVL-SILL---DFGPLSSEEsdenflLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
3-306 5.58e-32

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 123.97  E-value: 5.58e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283   3 EHDYHEDYGFSSFNDSSQEEHQDFLQFSKVFlpcmYLVVFVCGLVGNSLVLVIsIFYHKLQSLTDVFLVNLPLADLVFVC 82
Cdd:PHA02638   74 DYEYENNITYELINIKNKCMYPSISEYIKIF----YIIIFILGLFGNAAIIMI-LFCKKIKTITDIYIFNLAISDLIFVI 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  83 TLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLV 162
Cdd:PHA02638  149 DFPFIIYNEFDQWIFGDFMCKVISASYYIGFFSNMFLITLMSIDRYFAILYPISF--QKYRTFNIGIILCIISWILSLII 226
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 163 SLPQIIygnVFNLDKLICGYHD--EAIS----TVVLATQMT---------------LGFFLPLLTMIVCYSVIIKTLLHA 221
Cdd:PHA02638  227 TSPAYF---IFEASNIIFSAQDsnETISnyqcTLIEDNEKNnisflgrilqfeiniLGMFIPIIIFAFCYIKIILKLKQL 303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 222 GGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSThweyYAMTSFH--------------YTIMVTEAIAYLRACLNPVL 287
Cdd:PHA02638  304 KKSKKTKSIIIVSIIIICSLICWIPLNIVILFATM----YSFKGFNsiisehicgfiklgYAMMLAEAISLTHCCINPLI 379
                         330
                  ....*....|....*....
gi 1894925283 288 YAFVSLKFRKNFWKLVKDI 306
Cdd:PHA02638  380 YTLIGENFRMHLLMIFRNI 398
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
32-299 6.90e-32

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 120.83  E-value: 6.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGI-HEWVFGQVMCKSLLGIYT 110
Cdd:cd15091     1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLmNSWPFGDVLCKIVISIDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGNVF---NLDKLICG--YHDE 185
Cdd:cd15091    81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLK--AKIINICIWLLSSSVGISAIVLGGTKvreDVDSTECSlqFPDD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AIS---TVVLATQMTLGFFLPLLTMIVCYSVIIKTL----LHAGGFQKHRSL----KIIFLVMAVFLLTQMP---FNLMK 251
Cdd:cd15091   159 DYSwwdTFMKICVFIFAFVIPVLIIIVCYTLMILRLksvrLLSGSREKDRNLrritRLVLVVVAVFVVCWTPihiFILVE 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1894925283 252 FIRSTHWEYYAMTSFHYTImvteAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15091   239 ALGSVSHSTAAVSSYYFCI----ALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
34-297 1.13e-31

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 120.26  E-value: 1.13e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE--WVFGQVMCKSLLGIYTI 111
Cdd:cd15189     3 IPPFIFSLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQfnWPFGELLCRVVNGVIKV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRmtWGKVTSLLIWVISLLVSLPQIIYGNV-----FNLDKLICGYHDEA 186
Cdd:cd15189    83 NLYTSIYLLVMISQDRYLALVKTMAARRLRRRR--YAKLICVLIWVVGLLLSIPTFLLRKIkaipdLNITACVLLYPHEA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLH---AGGFQKHRSLKIIFLVMAV---FLLTQMPFNLMKF-------- 252
Cdd:cd15189   161 WHFAHIVLLNIVGFLLPLLVITFCNYNILQALRTreeSTRCEDRNDSKATALVLAVtllFLVCWGPYHFFTFldflfdvg 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1894925283 253 -IRSTHWEYYamtsFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15189   241 vLDECFWEHF----IDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
32-299 1.92e-31

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 119.43  E-value: 1.92e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLP---FWAYAGIHeWVFGQVMCKSLLGI 108
Cdd:cd15161     1 ILFALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPmrlVYHLSGNH-WPFGEVPCRLAGFL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQII-YGNVFNLDKLIC-GYHDEA 186
Cdd:cd15161    80 FYLNMYASLYFLACISVDRFLAIVHPVKS--MKIRKPLYAHVVCGFLWVIVTVAMAPLLVsPQTVEVNNTTVClQLYREK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATqMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKH---RSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAM 263
Cdd:cd15161   158 ASRGALVS-LAVAFTIPFVTTVTCYLLIIRSLRTGKREEKPlkdKAIKMIILVLTIFLICFVPYHISRYIYILSHNGAGA 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1894925283 264 TSFHYTIM-----VTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15161   237 SCSSRRGLalanrITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
33-299 2.76e-31

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 119.14  E-value: 2.76e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIH--EWVFGQVMCKSLLGIYT 110
Cdd:cd15921     2 FYPTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLnsHWPFGDIACRIILYVLY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNVF---NLDKLICGYHDeAI 187
Cdd:cd15921    82 VNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAG--IICGLIWILMGLASSPLLFAKSKQhdeGSTRCLELAHD-AV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 STVVLATQMTL--GFFLPLLTMIVCYSVIIKTLLHAGGFQK------HRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWE 259
Cdd:cd15921   159 DKLLLINYVTLpvGFVVPFMTVIFCYIFIIKNLLKPSPALGrtrpsrRKACALIIISLGIFLVCFLPYHIVRTIHLITER 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1894925283 260 YYAMT-----SFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15921   239 QIKEScgyilRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
32-296 3.70e-31

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 118.70  E-value: 3.70e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFyhKLQSLTD-VFLVNLPLADLVFVCTLPF--WAYAGIHEWVFGQVMCKSLLGI 108
Cdd:cd15372     1 RLVPSLYTLVFLVGLPANGLALWVLAT--QVKRLPStIFLINLAVADLLLILVLPFkiSYHFLGNNWPFGEGLCRVVTAF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGkvTSLLIWVISLLVSLPQIIYGNVFNLDKL-ICGYHD--- 184
Cdd:cd15372    79 FYGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALC--MCTAIWLIAAALTLPLTLQRQSYPLERLnITLCHDvlp 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 ----EAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHrSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEY 260
Cdd:cd15372   157 ldeqDTYLFYYFACLAVLGFLLPLVVILFCYGSVLHTLLRSGQRYGH-AMKLTVLVLVSFVLCFTPSNLLLLLHYSDPTL 235
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1894925283 261 YAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15372   236 DDGGNLYIVYMVSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
37-299 1.29e-30

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 117.27  E-value: 1.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA---YAGIheWVFGQVMCKSLLGIYTINF 113
Cdd:cd15092     6 VYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGtdiFLGF--WPFGNALCKTVIAIDYYNM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLI-C--------GYHD 184
Cdd:cd15092    84 FTSTFTLTAMSVDRYVAICHPIKALDVRTPHK--AKVVNVCIWALASVVGVPVMVMGSAQVEDEEIeClveiptpqDYWD 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVLatqmTLGFFLPLLTMIVCYSVIIKTL----LHAGGFQKHRSL----KIIFLVMAVFLLTQMPFNLMKFIRST 256
Cdd:cd15092   162 PVFGICVF----LFSFIIPVLIISVCYSLMIRRLrgvrLLSGSKEKDRNLrritRLVLVVVAVFVGCWTPIQIFVLAQGL 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1894925283 257 HWEYYAMTSFHYTIMVTeAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15092   238 GVQPSSETAVAILRFCT-ALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
33-297 1.85e-30

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 116.79  E-value: 1.85e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15381     2 FQPIYLWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAinISNGFNWPFGEFLCKSVNAVIY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNV-----FNLDKLICGYHDE 185
Cdd:cd15381    82 MNLYSSIYFLMMVSIDRYLALVKTMSS--GRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVmyfpeYNITACVLDYPSE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQ------KHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTH-- 257
Cdd:cd15381   160 GWHVALNILLNVVGFLIPLSIITFCSTQIIQVLRNNKMQKfkeiqtERKATVLVLAVLLMFFICWLPFHIFTFLDTLHkl 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1894925283 258 -------WEYYAMTSFHYTIMVteaiAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15381   240 glisgcrWEDILDIGTQIATFL----AYSNSCLNPLLYVIVGKHFRK 282
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
32-299 3.97e-30

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 115.98  E-value: 3.97e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQ--SLTDVFLVNLPLADLVF-VCTLPFWA--YAgIHEWVFGQVMCKSLL 106
Cdd:cd15098     1 VIVPVVFGLIFCLGVLGNSLVITVLARVKPGKrrSTTNVFILNLSIADLFFlLFCVPFQAtiYS-LPEWVFGAFMCKFVH 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 107 GIYTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNVFNL----DKLIC-- 180
Cdd:cd15098    80 YFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNAL--LGVLVIWVLSLAMASPVAVHQDLVHHwtasNQTFCwe 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 181 GYHDEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTL---LHAGGFQ----KHRSLKIIFLVMAVFLLTQMPFNLMKFI 253
Cdd:cd15098   158 NWPEKQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLhkkLKNMSKKsersKKKTAQTVLVVVVVFGISWLPHHIIHLW 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1894925283 254 RSTHWEYYAMTSFHYTImVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15098   238 VEFGDFPLTQASFVLRI-TAHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
37-299 7.49e-30

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 115.19  E-value: 7.49e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKlQSLTDVFLVNLPLADLVFVCTLPFWAY--AGIHEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15114     6 LYAVVFLVGVPGNALVAWVTGFEAK-RSVNAVWFLNLAVADLLCCLSLPILAVpiAQDGHWPFGAAACKLLPSLILLNMY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNV---FNLDKLICGYH---DEAIS 188
Cdd:cd15114    85 ASVLLLTAISADRCLLVLRPVWCQNHRRARLAW--IACGAAWLLALLLTVPSFIYRRIhqeHFPEKTVCVVDyggSTGVE 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTH---WEYYAMTS 265
Cdd:cd15114   163 WAVAIIRFLLGFLGPLVVIASCHGVLLVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPYHVVGLIIAASapnSRLLANAL 242
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1894925283 266 FHYTIMVteAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15114   243 KADPLTV--SLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
32-299 2.32e-29

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 114.11  E-value: 2.32e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYA-GIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15094     1 LISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTmILKYWPFGAAMCKIYMVLTS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGN-VFNLDKLIC------GYH 183
Cdd:cd15094    81 INQFTSSFTLTVMSADRYLAVCHPIRS--MRYRTPFIAKVVCATTWSISFLVMLPIILYAStVPDSGRYSCtivwpdSSA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 184 DEAISTVVLATqMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQK-------HRSL-KIIFLVMAVFLLTQMPFNLMKFIRS 255
Cdd:cd15094   159 VNGQKAFTLYT-FLLGFAIPLLLISVFYTLVILRLRTVGPKNKskekrrsHRKVtRLVLTVISVYIICWLPYWAFQVHLI 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1894925283 256 THWEYYAMTSFHYTI-MVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15094   238 FLPPGTDMPKWEILMfLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
38-299 2.69e-29

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 113.14  E-value: 2.69e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL--VFVCtLPFWAYA-GIHEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15001     6 YVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLllLVFC-VPLKTAEyFSPTWSLGAFLCKAVAYLQLLSFI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQII------YGNVFNLDKLIC--GYHDEA 186
Cdd:cd15001    85 CSVLTLTAISIERYYVILHPMKAKSFCTIGRA--RKVALLIWILSAILASPVLFgqglvrYESENGVTVYHCqkAWPSTL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMTLGFFLPLLTMIVCYSVIiktllhaggfQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSF 266
Cdd:cd15001   163 YSRLYVVYLAIVIFFIPLIVMTFAYARD----------TRKQVIKMLISVVVLFAVCWGPLLIDNLLVSFDVISTLHTQA 232
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1894925283 267 HYTI-MVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15001   233 LKYMrIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
34-296 4.22e-29

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 113.36  E-value: 4.22e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15380     3 LPTFIIAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAenIRNQFNWPFGNFLCRVISGVIKA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGNV-----FNLDKLICGYHDEA 186
Cdd:cd15380    83 NLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQ--AQVICLLIWVFGGLLSIPTFLFRSVkhvpdLNISACILLFPHEA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMTLGFFLPLLTMIVCYSVIIKTL--------LHAGGFQKHRSLKIIFLVMAVFLLTQMPFNL--------- 249
Cdd:cd15380   161 WHFARRVELNIVGFLLPLAAIVFFNFHIIASLrerteesrKRCGGLKDTKATRLILTLVLMFLVCWTPYHFfafldflfq 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1894925283 250 MKFIRSTHWEYYamtsFHYTIMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15380   241 VEVIQGCFWEEF----IDLGLQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
32-297 5.72e-29

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 112.95  E-value: 5.72e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE--WVFGQVMCKSLLGIY 109
Cdd:cd15968     1 ILLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRdrWLFGDFMCRLVRFLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRmtWGKVTSLLIWVISLLVSLPQIIYGNV-FNLDKLIC---GYHDE 185
Cdd:cd15968    81 YFNLYGSILFLTCISVHRYLGICHPMRPWHKETRR--AAWLTCVLVWILVFAQTLPILIFARTgIIRNRTVCydlAPPAL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMTL-GFFLPLLTMIVCYSVIIKTLLHAGG-------FQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTH 257
Cdd:cd15968   159 FPHYVPYGMALTVsGFLLPFSIILWCYCLVVRTLCRTLGpaeppaqARRRKSIRTIVTVTLLFALCFLPFHITRTIYLAV 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1894925283 258 WEY-----YAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15968   239 RVTpgvpcHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKFGR 283
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
32-299 7.49e-29

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 112.74  E-value: 7.49e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE-WVFGQVMCKSLLGIYT 110
Cdd:cd15089     1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMEtWPFGELLCKAVLSIDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKrmTWGKVTSLLIWVISLLVSLPQIIYGNVFNLD--KLICGYH----D 184
Cdd:cd15089    81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTP--AKAKLINICIWVLSSGVGVPIMVMAVTKTPRdgAVVCMLQfpspS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTL----LHAGGFQKHRSL----KIIFLVMAVFLLTQMPFNLMKFIRST 256
Cdd:cd15089   159 WYWDTVTKICVFIFAFVVPILVITVCYGLMILRLrsvrLLSGSKEKDRNLrritRMVLVVVAAFIICWTPIHIFVIVWTL 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1894925283 257 ----HWEYYAMTSFHYTImvteAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15089   239 vdidRRNPLVVAALHLCI----ALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
35-299 1.91e-28

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 111.61  E-value: 1.91e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  35 PCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWA--YAgIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15095     4 PLIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFlVCCVPFTAalYA-TPSWVFGDFMCKFVNYMMQV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIY----GNVFNLDKLICGYH--DE 185
Cdd:cd15095    83 TVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVA--VVVSACIWIVSFLLSIPVAIYyrleEGYWYGPQTYCREVwpSK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHA--------------GGFQKHRSLKIIFLVMAVFLLTQMPFNLMK 251
Cdd:cd15095   161 AFQKAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRsvdgnnqseqlserALRQKRKVTRMVIVVVVLFAICWLPNHVLN 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1894925283 252 FIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15095   241 LWQRFDPNFPETYATYALKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
32-288 3.46e-28

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 111.01  E-value: 3.46e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFW--AYAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd16001     1 ILLPVTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLivNYAMRDRWPFGDFLCKLVRFLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYH----DE 185
Cdd:cd16001    81 YTNLYGSILFLTCISVHRFLGVCYPIRSLAYRTRRL--AVIGSAATWILVVLQLLPTLVYARTGSINNRTVCYDltspDN 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMT-LGFFLPLLTMIVCYSVIIKTLLHAGGFQ------KHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHW 258
Cdd:cd16001   159 FGNYFPYGMVLTvTGFLIPFLIILLCYCLMIKSLIRSEEAAgvgkaaRAKSIRTILLVCGLFALCFVPFHITRTIYLFVR 238
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1894925283 259 EYYAMTSfhyTIMVTEAIAY--------LRACLNPVLY 288
Cdd:cd16001   239 VYLVQDC---PLLQFVSLAYkiwrplvsFNSCINPLLY 273
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
33-296 3.78e-28

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 110.55  E-value: 3.78e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15160     2 FLPVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIdyTANHHNWTFGPLSCKVVGFFFY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNL--DKLICGYH---DE 185
Cdd:cd15160    82 TNIYASIGFLCCIAVDRYLAVVHPLRF--RGLRTRRFALKVSASIWVLELGTHSVFLGHDELFRDepNHTLCYEKypmEG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATqMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFL---VMAVFLLTQMPFNLMKFIRSTHWEYY- 261
Cdd:cd15160   160 WQASYNYAR-FLVGFLIPLSLILFFYRRVLRAVRQSPSLEREEKRKIIGLllsIVVIFLLCFLPYHVVLLVRSVIELVQn 238
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1894925283 262 AMTSFHYTIMVTEAIAYLRACLN----PVLYAFVSLKFR 296
Cdd:cd15160   239 GLCGFEKRVFTAYQISLCLTSLNcvadPILYIFVTEDVR 277
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
35-299 3.84e-28

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 110.63  E-value: 3.84e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  35 PCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFV-CTLPFWA--YAgIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd14971     4 PLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLlFCVPFTAtiYP-LPGWVFGDFMCKFVHYFQQV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNVFNL---DKLICgYHDEAIS 188
Cdd:cd14971    83 SMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNAL--AASGCIWVVSLAVAAPVLALHRLRNYtpgNRTVC-SEAWPSR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLATQMTL---GFFLPLLTMIVCYSVIIKTL---------LHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLmkFIRST 256
Cdd:cd14971   160 AHRRAFALCTflfGYLLPLLLICVCYAAMLRHLwrvavrpvlSEGSRRAKRKVTRLVLVVVVLFAACWGPIHA--ILLLV 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1894925283 257 HWEYYAMTSFHYTI-MVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14971   238 ALGPFPLTYATYALrIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
34-296 4.97e-28

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 110.23  E-value: 4.97e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIH--EWVFGQVMCKSLLGIYTI 111
Cdd:cd14987     3 LSFFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQhnQWPMGEFTCKITHLIFSI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNVFNL---DKLIC--GYHDEA 186
Cdd:cd14987    83 NLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVR--RIICVLVWLLAFVASLPDTYFLKTVTSpsnNETYCrsFYPEES 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMT---LGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYY-- 261
Cdd:cd14987   161 FKEWLIGMELVsivLGFVIPFPIIAVFYFLLARAISASSDQERKSSRKIIFSYVVVFLVCWLPYHTVVLLDILSFLHLip 240
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1894925283 262 ---AMTSFHYT-IMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd14987   241 fscQLENFLYAaLHVTQCFSLVHCCVNPILYSFINRNYR 279
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
32-299 6.31e-28

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 110.21  E-value: 6.31e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPF-WAYAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15087     1 VALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPInIAEHLLQQWPFGELLCKLILSIDH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKaynqqAKRMTW-----GKVTSLLIWVISLLVSLPQIIYGNVFN--LDKLICGY- 182
Cdd:cd15087    81 YNIFSSIYFLTVMSVDRYLVVLATVR-----SRRMPYrtyraAKIVSLCVWLLVTIIVLPFTVFAGVYSneLGRKSCVLs 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 183 --HDEA-------ISTVVlatqmtLGFFLPLLTMIVCYSVIIKTL----LHAGG----FQKHRSLKIIFLVMAVFLLTQM 245
Cdd:cd15087   156 fpSPESlwfkasrIYTLV------LGFAIPVSTICILYTMMLYKLrnmrLNSNAkaldKAKKKVTLMVLVVLAVCLFCWT 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 246 PFNLMKFIRSThweyyamTSFHYTIMVT------EAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15087   230 PFHLSTVVALT-------TDLPQTPLVIgisyfiTSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
32-299 7.88e-28

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 109.86  E-value: 7.88e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE--WVFGQVMCKSLLGIY 109
Cdd:cd14988     1 VVLFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDytWLWGSFLCKFTHYFY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGY------H 183
Cdd:cd14988    81 FANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRR--ALCAGIWVLSAIIPLPEVVHMQLLDGVEPMCLFlapfetY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 184 DEAISTVVLATqMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEY--- 260
Cdd:cd14988   159 DEWALAVSLLT-LIIGFLIPFSIIAVFNVLTARYIRTAGRPESRRHCLLIYAYILVFVVCWLPYHVTLLLLTLHGSHisl 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1894925283 261 --YAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14988   238 hcNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
36-299 1.37e-27

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 109.02  E-value: 1.37e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGIHE-WVFGQVMCKSLLGIYTINF 113
Cdd:cd15206     5 PLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLaVFCMPFTLVGQLLRnFIFGEVMCKLIPYFQAVSV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVtsLLIWVISLLVSLPQIIYGNVFNLDK--------LICGYHDE 185
Cdd:cd15206    85 SVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVI--AGIWLLSFLIMSPILVFSNLIPMSRpgghkcreVWPNEIAE 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMtlgFFLPLLTMIVCYSVIIKTLLHAggfqKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTS 265
Cdd:cd15206   163 QAWYVFLDLML---LVIPGLVMSVAYGLISWTLLEA----KKRVIRMLFVIVVEFFICWTPLYVINTWKAFDPPSAARYV 235
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1894925283 266 FHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15206   236 SSTTISLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
32-298 6.32e-27

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 107.53  E-value: 6.32e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPF--WAYAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15373     1 ILLPVSYGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLlvYYYADENDWPFSEALCKIVRFLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAynqqakrMTWGKV-----TSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHD 184
Cdd:cd15373    81 YTNLYCSILFLLCISVHRFLGVCYPVRS-------LRWLKVryariVSVVVWVIVLACQSPVLYFVTTSDKGGNITCHDT 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAIS-----TVVLATQMTLGFFLPLLTMIVCYSVIIKTLLH--AGGFQ----KHRSLKIIFLVMAVFLLTQMPFNLMKFI 253
Cdd:cd15373   154 SSPElfdqfVVYSSVMLVLLFCVPFVVILVCYALMVRKLLKpsAGTSTnsrsKKKSVKMIIIVLAVFILCFLPFHVTRTL 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1894925283 254 ----RSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKN 298
Cdd:cd15373   234 yysfRSMDLSCGTLNAINLAYKVTRPLASANSCLDPILYFLAGQSFRSN 282
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
36-292 6.33e-27

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 107.63  E-value: 6.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA-YAGIHEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15156     5 CVFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIfYFVQRNWPFGDLLCKISVTLFYTNMY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGNVFN---------LDKLICGYHDE 185
Cdd:cd15156    85 GSILFLTCISVDRFLAIVYPFRSKTLRTKRN--AKIVCAAVWLTVLAGSLPASFFQSTNNqlnnnsetcFENFSSKTWKT 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQmTLGFFLPLLTMIVCYSVIIKTL-----LHAGGFQKHRSLKIIFLVMAVFLLTQMPFN----LMKFIRST 256
Cdd:cd15156   163 YLSKIVIFIE-IVGFFIPLILNVTCSTMVLKTLrrpntLSRSKLNKKKVLKMIFVHLFIFCFCFIPYNvnlvLYSLVRTQ 241
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1894925283 257 HWEYYAMTSFHYTIM-VTEAIAYLRACLNPVLYAFVS 292
Cdd:cd15156   242 TFKNCSVVAAVRTMYpITLCIAVSNCCFDPIVYYFTS 278
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
37-299 8.33e-27

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 107.00  E-value: 8.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIH-EWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15090     6 LYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMgTWPFGNILCKIVISIDYYNMFT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLI---------CGYHDEA 186
Cdd:cd15090    86 SIFTLCTMSVDRYIAVCHPVKALDFRTPRN--AKIVNVCNWILSSAIGLPVMFMATTKYRQGSIdctltfshpSWYWENL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLatqmTLGFFLPLLTMIVCYSVIIKTL----LHAGGFQKHRSL----KIIFLVMAVFLLTQMP---FNLMKFIRS 255
Cdd:cd15090   164 LKICVF----IFAFIMPVLIITVCYGLMILRLksvrMLSGSKEKDRNLrritRMVLVVVAVFIVCWTPihiYVIIKALVT 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1894925283 256 THWEYYAMTSFHYTImvteAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15090   240 IPETTFQTVSWHFCI----ALGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
38-299 8.66e-27

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 107.13  E-value: 8.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFyHKLQSLTDVFLVNLPLADLVFVCTLPFWAY--AGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15117     7 YSSAFVLGTLGNGLVIWVTGF-RMTRTVTTVCFLNLAVADFAFCLFLPFSVVytALGFHWPFGWFLCKLYSTLVVFNLFA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQakrmTWGKVT--SLLIWVISLLVSLPQIIYGN----------VFNLDKLICGYH 183
Cdd:cd15117    86 SVFLLTLISLDRCVSVLWPVWARNHR----TPARAAlvAVGAWLLALALSGPHLVFRDtrkengcthcYLNFDPWNETAE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 184 DEAISTVVLATQMT--------LGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIrs 255
Cdd:cd15117   162 DPVLWLETVVQRLSaqvitrfvLGFLVPLVIIGGCYGLIAARLWREGWVHSSRPFRVLTAVVAAFFLCWFPFHLVSLL-- 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1894925283 256 THWEYYAMTSFHYTIMV-----TEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15117   240 ELVVILNQKEDLNPLLIlllplSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
32-298 1.13e-26

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 106.81  E-value: 1.13e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIH--EWVFGQVMCKSLLGIY 109
Cdd:cd15370     1 VFLPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINgnNWIYGEALCKVLIGFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATkayNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKL-ICGYHD---E 185
Cdd:cd15370    81 YGNMYCSILFMTCLSVQRYWVIVNPM---SHSRKKANIAIGISLAIWLLILLVTIPLYLVKQTVFIPALdITTCHDvlpE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTV----VLATQMTLGFFLPLLTMIVCYSVIIKTL-----LHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRST 256
Cdd:cd15370   158 QLLVGdmfnYFLSLAIGVFLFPAFLTAVAYVLMIRALkssinDESIEKKRKRAIKLIVTVLVMYLICFTPSNLLLVVHYF 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1894925283 257 HWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKN 298
Cdd:cd15370   238 LLKNQGQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFRDH 279
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
35-297 1.54e-26

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 106.37  E-value: 1.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  35 PCMYLVVFVCGLVGNSLVLVI--SIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15147     4 PIVYSIIFVLGLIANCYVLWVfaRLYPSKKLNEIKIFMVNLTIADLLFLITLPFWIvyYHNEGNWILPKFLCNVAGCLFF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGN-------VFNLDKLICGYH 183
Cdd:cd15147    84 INTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKR--GIIISVAIWVIIVASASYFLFMDStntvkidSGNFTRCFEGYE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 184 DEAiSTVVLATQMTL--GFFLPLLTMIVCYSVIIKTLLHAGGFQ------KHRSLKIIFLVMAVFLL-------TQMPFN 248
Cdd:cd15147   162 KDN-SKPVLIIHFIIigLFFLVFLLILVCNLVIARTLLSQPVQGqrnagvKRRALWMVCTVLAVFVIcfvphhvVQGPWT 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1894925283 249 LMKFIRSTHWEyyamTSFHYTI----MVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15147   241 LAVLQQWRYWD----CQFRQALndahQITLCLMSTNCVLDPVIYCFLTKKFRK 289
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
37-296 1.59e-26

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 106.37  E-value: 1.59e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKlQSLTDVFLVNLPLADLVFVCTLPFW-AYAGI-HEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15119     6 IYIVAFVLGVPGNAIVIWVTGFKWK-KTVNTLWFLNLAIADFVFVLFLPLHiTYVALdFHWPFGVWLCKINSFVAVLNMF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGN--VFNLDKLIC--GYHDEAISTV 190
Cdd:cd15119    85 ASVLFLTVISLDRYISLAHPVWSHRYRTLKSAL--ILCGIVWLSAAAISGPALYFRDtmELSINVTICfnNFHKHDGDLI 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLA------TQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIR-STHWEYYAM 263
Cdd:cd15119   163 VMRhtilvwVRFFFGFLFPLLTMVVCYSLLAIKVKRRTLLISSKFFWTISAVIVAFFVCWTPYHIFSILElSIHHSSYLH 242
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1894925283 264 TSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15119   243 NVLRAGIPLATSLAFINSCLNPILYVLIGKKFK 275
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
33-296 1.82e-26

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 105.95  E-value: 1.82e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE-WVFGQVMCKSLLGIYTI 111
Cdd:cd15378     2 YLPTMYSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSYSNGqWLFGDFLCKSNRYLLHA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIY-GNVFNLDKLIC---GYHDEAI 187
Cdd:cd15378    82 NLYSSILFLTFISIDRYLLIKYPFREHILQKKRS--AVAISLAIWVLVTLELLPILTFiGPNLKDNVTKCkdyASSGDAT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 STVVLATQMTL-GFFLPLLTMiVCYSVIIKTLLH------AGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIR----ST 256
Cdd:cd15378   160 NSLIYSLFLTVtGFLIPLCVM-CFFYYKIALFLKnrnrqlANATSFEKPLTLVILAVVIFSVLFTPYHVMRNVRiasrLD 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1894925283 257 HWEYYAMTSFHYTIM--VTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15378   239 SIGVSECTLIIIKSLyiVTRPIAFLNSVINPVFYFLMGDHFR 280
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
35-299 3.48e-26

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 105.46  E-value: 3.48e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  35 PCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFV--CtLPFWAYAGI-HEWVFGQVMCKSLLGIYTI 111
Cdd:cd15096     4 PVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVvfC-VPFTATDYVlPTWPFGDVWCKIVQYLVYV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVtsLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAISTVV 191
Cdd:cd15096    83 TAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAI--VGIWIVILVANIPVLFLHGVVSYGFSSEAYSYCTFLTEV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 LAT----QMT---LGFFLPLLTMIVCYSVIIKTLLH--AGGFQ--------KHRSLKIIFLVMAVFLLTQMPFNLMKFIR 254
Cdd:cd15096   161 GTAaqtfFTSfflFSYLIPLTLICVLYMLMLRRLRRqkSPGGRrsaesqrgKRRVTRLVVVVVVVFAICWLPIHIILLLK 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1894925283 255 SthWEYYAMTSFHYTIMVT-EAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15096   241 Y--YGVLPETVLYVVIQILsNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
36-298 4.54e-26

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 104.72  E-value: 4.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15165     5 VVYIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSSKKQWPLGRTLCSFLESLYFVNMYG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPqiIY---GNVFNLDKLICGYHDEAISTVVL 192
Cdd:cd15165    85 SILIIVCISVDRYIAIRHPFLAKRLRSPRKA--AIVCLTIWVFVWAGSIP--IYsfhDKPTNNTRCFHGFSNKTWSKKVI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 193 ATQMTLGFFLPLLTMIVCYSVIIKTLL-HAGGFQKH----RSLKIIFLVMAVFLLTQMPFNLMKFI----RSTHW-EYYA 262
Cdd:cd15165   161 VVVEEFGFLIPMAVMVFCSVQIIRTLLdMRRPEQPKvkqnKSVKIVLSNLVVFLVCFTPYHLGIFLqflvKNDIInDCST 240
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1894925283 263 MTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKN 298
Cdd:cd15165   241 KQSIRLFVQVSMCLANVNCCLDAICYYFILKEFRES 276
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
32-297 4.74e-26

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 104.89  E-value: 4.74e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLP--FWAYAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15374     1 ILLPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPtlIYYYADHNHWPFGVVACKIVRFLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNVFNLDK-LICgyHDEA-- 186
Cdd:cd15374    81 YANLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAY--LICASVWLVVTVCLVPNLIFVTTSRKDNiTLC--HDTTrp 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 --------ISTVVlatqMTLGFFLPLLTMIVCYSVIIKTLL--------HAGGFQKHRSLKIIFLVMAVFLLTQMPFNLM 250
Cdd:cd15374   157 eefdhyvhYSSAV----MVLLFGIPCLVIVVCYGLMARRLCkprvgssrQQGPSSKKRSLKTIIMVLTVFAICFVPFHIT 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1894925283 251 KFI----RSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15374   233 RTLyyvaRLLKADCDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYRR 283
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
37-297 1.11e-25

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 103.68  E-value: 1.11e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV--FVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15012     5 LYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCvgIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYT 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKayNQQAKRMTWGKVTSLLIWVISLLVSLPQII-YGNVFNLD------KLICGYHDEAI 187
Cdd:cd15012    85 ASIGILVVISVERYIAILHPLR--CKQLLTAARLRVTIVTVWLTSAVYNTPYFVfSQTVEILVtqdgqeEEICVLDREMF 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 STVVLAT-QMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRslKIIFLVMAV---FLLTQMPFNLMKFIrsTHWEYYAM 263
Cdd:cd15012   163 NSKLYDTiNFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARR--KVVRLLVAVvvsFALCNLPYHARKMW--QYWSEPYR 238
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1894925283 264 TSFHYTIM---VTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15012   239 CDSNWNALltpLTFLVLYFNSAVNPLLYAFLSKRFRQ 275
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
37-299 2.12e-25

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 103.52  E-value: 2.12e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF--VCT----LPFWAyagiHE-WVFGQVMCKSLLGIY 109
Cdd:cd14997     6 VYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVllVCMpvalVETWA----REpWLLGEFMCKLVPFVE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPqIIYGNVFNLDKLICGYH------ 183
Cdd:cd14997    82 LTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRAL--VIIALIWLLALLTSSP-VLFITEFKEEDFNDGTPvavcrt 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 184 --DEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLK-----------IIFL---VMAVFLLTQMPF 247
Cdd:cd14997   159 paDTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPALESRRADAanrhtlrsrrqVVYMlitVVVLFFVCLLPF 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1894925283 248 NLMK--FIRSTHWEYYAMTSFHYTIMVT--EAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14997   239 RVVTlwIIFAPDEDLQALGLEGYLNLLVfcRVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
37-297 2.46e-25

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 103.29  E-value: 2.46e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15158     6 LYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVvyYVHKGQWLFGDFLCRISSYALYVNLY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKayNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGY----HDEAISTV 190
Cdd:cd15158    86 CSIYFMTAMSFTRFLAIVFPVQ--NLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKCFeppqSNQQLTKL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLATQMTL--GFFLPLLTMIVCYSVIIKTLLH--AGGFQKH----RSLKIIFLVMAVFLLTQMPFNLMK-----FIRSTH 257
Cdd:cd15158   164 LVLNYISLvvGFIIPFLVILICYAMIIRTLLKntMKARKQQssrkKAIRMIIIVLLAFLVSFMPYHIQRtihlhFLSRKD 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 258 WEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15158   244 STCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRR 283
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
32-299 2.58e-25

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 103.20  E-value: 2.58e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15159     1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIayYALGFDWPFGDWLCRLTALLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKayNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNL-DKLIC----GYHD 184
Cdd:cd15159    81 YINTYAGVNFMTCLSVDRYIAVVHPLR--RHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEMgGRITCmeypNFEK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAG---------GFQKhRSLKIIFLVMAVFLLTQMP--FNLMKF- 252
Cdd:cd15159   159 IKRLPLILLGACVIGFGVPVGIILFCYSQITLKLCRTAkenplteksGHHK-KACNVILLVLLVFVVCFSPyhLNIIQFm 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1894925283 253 IRSTHWEYY--AMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15159   238 IRKLLYQPScsELKAFKISLQITVCLMNLNCCLDPFIYFFACKGYKKKV 286
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
38-299 3.01e-25

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 103.08  E-value: 3.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGI-HEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15207     7 YSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDlLVGVFCMPFTLVDNIlTGWPFGDVMCKLSPLVQGVSVAA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKaynqqaKRMTWGK--VTSLLIWVISLLVSLPQII------YGNVFNLDKLICGYHDEAI 187
Cdd:cd15207    87 SVFTLVAIAVDRYRAVVHPTE------PKLTNRQafVIIVAIWVLALAIMIPQALvlevkeYQFFRGQTVHICVEFWPSD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 S-----TVVLatqMTLGFFLPLLTMIVCYSVIIKTL---------------LHAGGFQKHRSLKIIFLVMAVFLLTQMP- 246
Cdd:cd15207   161 EyrkayTTSL---FVLCYVAPLLIIAVLYVRIGYRLwfkpvpgggsasreaQAAVSKKKVRVIKMLIVVVVLFALSWLPl 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1894925283 247 ---FNLMKFIRSTHWEYYAMtsFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15207   238 htvTMLDDFGNLSPNQREVL--YVYIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
37-299 5.17e-25

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 102.44  E-value: 5.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL---VFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINF 113
Cdd:cd15392     6 MYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDIlmaVFCVPFSFIALLILQYWPFGEFMCPVVNYLQAVSV 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAynqqakRMTWGKVTSL--LIWVISLLVSLPQIIYGNVFN-----LDKLICGYHD-- 184
Cdd:cd15392    86 FVSAFTLVAISIDRYVAIMWPLRP------RMTKRQALLLiaVIWIFALATALPIAITSRLFEdsnasCGQYICTESWps 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 ---EAISTVVLatqMTLGFFLPLLTMIVCYSVIIKTL----------------LHAggfQKHRSLKIIFLVMAVFLLTQM 245
Cdd:cd15392   160 dtnRYIYSLVL---MILQYFVPLAVLVFTYTRIGIVVwakrtpgeaennrdqrMAE---SKRKLVKMMITVVAIFALCWL 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1894925283 246 PFNLMKFIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15392   234 PLNILNLVGDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
32-297 5.18e-25

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 102.28  E-value: 5.18e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKL-QSLTDVFLVNLPLADLVFVCTLPFWAY--AGIHEWVFGQVMCKSLLGI 108
Cdd:cd15926     1 IIISIVYSVVCALGLVGNLLVLYLMKSKQGWkKSSINLFVTSLAVTDFQFVLTLPFWAVenALDFTWLFGKAMCKIVSYV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINFYTSMLILTCITVDRFIVVVKATKayNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGN---VFNLDKLICGYHDE 185
Cdd:cd15926    81 TAMNMYASVFFLTAMSVARYHSVASALK--SKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTtatVSNEELCLVKFPDN 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AIST-----VVLATQMTLGFFLPLLTMIVCYSVIIKTLLH---AGGFQKHRS--LKIIFLVMAVFLLTQMP------FNL 249
Cdd:cd15926   159 RGNAqfwlgLYHAQKVLLGFLIPLGIISLCYLLLVRFITDkniTGSSTKRRSkvTKSVTIVVLSFFLCWLPnqalttWGI 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1894925283 250 MKFIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15926   239 LIKLNVVHFSYEYFTTQVYIFPITVCLAHSNSCLNPILYCLMRREFRK 286
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
32-299 7.47e-25

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 101.77  E-value: 7.47e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGI--HEWVFGQVMCKSLLGIY 109
Cdd:cd15368     1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIqrNHWIFGKPLCNVVTVLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGkvTSLLIWVISLLVSLP----QIIYgNVFNLDKLIC----- 180
Cdd:cd15368    81 YANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVA--ACIGMWLLVLTALSPlertDLTY-YVKELNITTCfdvlk 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 181 --GYHDEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHA----GGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIR 254
Cdd:cd15368   158 wtMLPNIAAWAAFLFTLFILLFLIPFIITVYCYVLIILKLVQTseryGREQKRRAIYLALIVLLVFITCFAPNNFILLAH 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1894925283 255 STHWEYYAMTSFHYtIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15368   238 MVSRLFYGKSLYHA-YKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
38-297 1.25e-24

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 101.13  E-value: 1.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGIHE-WVFGQVMCK------SLLGIy 109
Cdd:cd14969     7 LSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMsVVGYPLSFYSNLSGrWSFGDPGCViygfavTFLGL- 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 tinfyTSMLILTCITVDRFIVVVKATKAYNqqaKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICG-----YHD 184
Cdd:cd14969    86 -----VSISTLAALAFERYLVIVRPLKAFR---LSKRRALILIAFIWLYGLFWALPPLFGWSSYVPEGGGTScsvdwYSK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRS---------------LKIIFLVMAVFLLTQMPFNL 249
Cdd:cd14969   158 DPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKnsaitkrtkkaekkvAKMVLVMIVAFLIAWTPYAV 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1894925283 250 MKFIRSTHWEYyamtSFHYTIMVTEAI-AYLRACLNPVLYAFVSLKFRK 297
Cdd:cd14969   238 VSLYVSFGGES----TIPPLLATIPALfAKSSTIYNPIIYVFMNKQFRR 282
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
32-297 2.80e-24

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 100.27  E-value: 2.80e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVlVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPF----WAYAGihEWVFGQVMCKSLLG 107
Cdd:cd15339     1 VILPSFIGILCSTGLVGNILV-LFTIIRSRKKTVPDIYVCNLAVADLVHIIVMPFlihqWARGG--EWVFGSPLCTIITS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 108 IYTINFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNV--FNLDKLICGYHDE 185
Cdd:cd15339    78 LDTCNQFACSAIMTAMSLDRYIALVHPFRL--TSLRTRSKTIRINLLVWAASFILVLPVWVYAKVikFRDGLESCAFNLT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLAT--QMTLGFFLPLLTMIVCYSVI-------IKTLLHAGGFQKH-------RSLKIIFLVMAVFLLTQMPFNL 249
Cdd:cd15339   156 SPDDVLWYTlyQTITTFFFPLPLILICYILIlcytwemYRKNKKAGRYNTSiprqrvmRLTKMVLVLVGVFLVSAAPYHV 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1894925283 250 MKFIRSTHWEyyAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15339   236 IQLVNLSVSQ--PTLAFYVSYYLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
32-297 3.45e-24

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 99.84  E-value: 3.45e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPF---WAYAGiHEWVFGQVMCKSLLGI 108
Cdd:cd15369     1 RFVPSVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFkiaYHFSG-NDWLFGEAMCRVVTAA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINFYTSMLILTCITVDRFIVVVKATKAYNQqaKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKL-ICGYHDeai 187
Cdd:cd15369    80 FYCNMYCSILLMTCISVDRFLAVVYPMQSLSW--RTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPDLgITTCHD--- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 stvVLATQMTLG-------------FFLPLLTMIVCYSVIIKTLLHAGGF----QKHRSLKIIFLVMAVFLLTQMPFNLM 250
Cdd:cd15369   155 ---VLNEQLLMGyyvyyfsifsclfFFVPLIITTVCYVSIIRCLSSSSDVanssKKTRALFMAVAVFCVFVICFGPTNVL 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1894925283 251 KFIRSTHWEYYAMTSFHYTI-MVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15369   232 LLAHYVRFAYTSTNDASYFAyLLCVCVGSISCCLDPLIYYYGSSQCQK 279
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
39-291 8.41e-24

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 98.71  E-value: 8.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE-WVFGQVMCKSLLGIYTINFYTSM 117
Cdd:cd14975     8 SLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGtWDFGLAACKGCVYVCAVSMYASV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 118 LILTCITVDRFIVVVKATKAYNQQAKRMTWGKVtsLLIWVISLLVSLPQIIYGNV-FNLDKLICGYHD--EAISTVVLAT 194
Cdd:cd14975    88 FLITLMSLERFLAVSRPFVSQGWRAKALAHKVL--AIIWLLAVLLATPVIAFRHVeETVENGMCKYRHysDGQLVFHLLL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 195 QMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMP---FNLMKFIRSTHWEYYAMTSFHYT-- 269
Cdd:cd14975   166 ETVVGFAVPFTAVVLCYSCLLRRLRRRRFRRRRRTGRLIASVVVAFAACWLPyhvGNLLEVVSELIGGSKMAGTLGKVae 245
                         250       260
                  ....*....|....*....|....
gi 1894925283 270 --IMVTEAIAYLRACLNPVLYAFV 291
Cdd:cd14975   246 agRPIAGALAFLSSSINPLLYAFA 269
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
33-297 8.75e-24

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 98.67  E-value: 8.75e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYA-GIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd14999     1 AIGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTyFLKKWYFGDVGCRLLFSLDFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAynqqAKRMT-WGKVTSLLIWVISLLVSLPQIIY------GNVFNLDKLICGYHD 184
Cdd:cd14999    81 TMHASIFTLTVMSTERYLAVVKPLDT----VKRSKsYRKLLAGVIWLLSLLLTLPMAIMirlvtvEDKSGGSKRICLPTW 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAIST-VVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGG---------FQKHRSLKIIFLVMAVFLLTQMPFNLMKFIR 254
Cdd:cd14999   157 SEESYkVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAaasnssrkrLPKQKVLKMIFTIVLVFWACFLPFWIWQLLY 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1894925283 255 STHWEYYAMTSFHYTI-MVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd14999   237 LYSPSLSLSPRTTTYVnYLLTCLTYSNSCINPFLYTLLTKNYKE 280
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
33-292 1.11e-23

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 98.61  E-value: 1.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIF-YHKLQSLtDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15967     2 FLPPVYILVFVVGLVGNVWGLKSLLAnWKKLGNI-NVFVLNLGLADLLYLLTLPFLVvyYLKGRKWIFGQVFCKITRFCF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNqqakRMTWGK--VTSLLIWVISLLVSLPQIIYGNVFNlDKLICgYH---D 184
Cdd:cd15967    81 NLNLYGSIGFLTCISVYRYLAIVHPMRVMG----RITTTHsvVISALVWLLVVIQSLPDLFFSKTNS-NGTKC-FDttfN 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVL--ATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQ---KHRSLKIIFLVMAVFLLTQMPF----NLMKFIRS 255
Cdd:cd15967   155 DYLESYLTysLGWTVTGFVIPLLIILGCYGHVVVVLCRNNNVDkglKQRCLKLVIILIVLFSVCYIPYhvfrNLNLLSRI 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 256 THWEYYAMTSFHYTIM---VTEAIAYLRACLNPVLYAFVS 292
Cdd:cd15967   235 LQKQGSCTQWFRGIYIahqVSRGLVCLNSALNPLVYLMGS 274
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
38-297 3.71e-23

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 97.25  E-value: 3.71e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVL-VISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE--WVFGQVMCKSLLGIYTINFY 114
Cdd:cd15925     7 YGLVCAIGLLGNLAVMyLLRNCARRAPPPIDVFVFNLALADFGFALTLPFWAVESALDfhWPFGGAMCKMVLTATVLNVY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVvkATKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNL------------DKLICGY 182
Cdd:cd15925    87 ASVFLLTAMSVTRYWVV--ASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVcgvelcllkfpsNYWLGAY 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 183 HDEaistvvlatQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRS-----LKIIFLVMAVFLLTQMPFNLMKF----- 252
Cdd:cd15925   165 HLQ---------RVVVAFVVPLGVITTSYLLLLSFLQQHKVNQNNRQrqsviARSVRLVVASFFLCWFPNHVVTFwgvlv 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1894925283 253 -IRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15925   236 kFRAVPWNSTFYFIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQ 281
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
33-292 4.00e-23

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 96.79  E-value: 4.00e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLviSIFYHKLQSL-TDVFLVNLPLADLVFVCTLPFWAYAGIH--EWVFGQVMCKSLLGIY 109
Cdd:cd15371     2 LIPAVYIIVVVLGVPSNAIIL--WMLFFRLRSVcTAIFYANLAISDLLFCITLPFKIVYHLNgnNWVFGETMCRIITITF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATkAYNQQAKRmTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKL-ICGYHD---- 184
Cdd:cd15371    80 YGNMYCSILLLTCISINRYLAIVHPF-IYRSLPKK-TYAVLICALVWTIVFLYMLPFFILKQTYYLKELnITTCHDvlpe 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 ----EAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTlLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEY 260
Cdd:cd15371   158 ceqnSNFQFYYFISMAVFGFLIPLVITIFCYISIIRT-LNAYEHKWFWYVKITALVLIIFTICFAPSNVILIIHHFNYYY 236
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1894925283 261 YAMTSFHYTIMVTEAIAYLRACLNPVLYAFVS 292
Cdd:cd15371   237 FNNDNLYSIYLIALCLGSLNSCLDPFLYFLMS 268
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
38-299 6.65e-23

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 96.37  E-value: 6.65e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPF-WAYAGIHEWVFGQVMCKSLLGIYTINFYTS 116
Cdd:cd15154     7 YSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLrIYYYANHYWPFGNFLCQFSGSIFQMNMYGS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 117 MLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNldkliCGYHDEAISTV------ 190
Cdd:cd15154    87 CLFLMCINVDRYLAIVHPLRF--RHLRRPKVARLLCLAVWALILGGSVPAAIVHSSSD-----CLLHGEKVYRCfesfsd 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 --------VLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMA---VFLLTQMPFN----LMKFIRS 255
Cdd:cd15154   160 ndwkgllpLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEPQQGRRRKTVRLLLVnlvIFLICFVPYNttlaVYGLLRA 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1894925283 256 --THWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15154   240 nlVEDTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
32-299 1.00e-22

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 96.04  E-value: 1.00e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV--FVCTLPFWAYAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15202     1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMitLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQakrmTWGKVTSLLIWVISLLVSLPQIIYGNVF------NLDKLICgyH 183
Cdd:cd15202    81 YCSVHVSAYTLTAIAVDRYQAIMHPLKPRISK----TKAKFIIAVIWTLALAFALPHAICSKLEtfkyseDIVRSLC--L 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 184 DEAISTVVLATQM------TLGFFLPLLTMIVCYSVIIKTLL-------------HAGGFQKHRSLKIIFLVMAVFLLTQ 244
Cdd:cd15202   155 EDWPERADLFWKYydlalfILQYFLPLLVISFAYARVGIKLWasnmpgdatteryFALRRKKKKVIKMLMVVVVLFALCW 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1894925283 245 MPFNLMKFIRSTHwEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15202   235 LPFNIYVLLLSSK-PDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
32-299 1.44e-22

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 95.80  E-value: 1.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGIHE-WVFGQVMCKSLLGIY 109
Cdd:cd15927     1 YVVPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDlLLLLTCVPFTSTIYTLDsWPFGEFLCKLSEFLK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNVF------NLDKLICGYH 183
Cdd:cd15927    81 DTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRT--LVTAASIWIVSILLAIPEAIFSHVVtftltdNQTIQICYPY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 184 DEAIsTVVLATQMTLGFFL-----PLLTMIVCYSVIIKTLL-----HAGGFQKH--------RSLKIIFLVMAV-FLLTQ 244
Cdd:cd15927   159 PQEL-GPNYPKIMVLLRFLvyyliPLLIIGVFYVLMARHLIrstrnIGSGQNQAaqrqiearKKVAKTVLAFVVlFAVCW 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1894925283 245 MPFNLMKFIRstHWEYYAMTSF----HYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15927   238 LPRHVFMLWF--HFAPNGLVDYnafwHVLKIVGFCLSFINSCVNPVALYLLSGSFRRHF 294
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
40-290 1.82e-22

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 95.27  E-value: 1.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA-YAGIHEWVFGQVMCKSLLGIYTINFYTSML 118
Cdd:cd15121     9 LAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLhFLSGGGWEFGSVVCKLCHYVCGVSMYASIF 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 119 ILTCITVDRFIVVVKATKAYNQQAKRMTWGKVtsLLIWVISLLVSLPQIIYGNV--FNLDKLICGYHDEAISTVV--LAT 194
Cdd:cd15121    89 LITLMSMDRCLAVAKPFLSQKMRTKRSVRALL--LAIWIVAFLLSLPMPFYRTVlkKNINMKLCIPYHPSVGHEAfqYLF 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 195 QMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHweyyAMTSFHYTIMVTE 274
Cdd:cd15121   167 ETITGFLLPFTAIVTCYSTIGRRLRSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAG----ALQNQAGNASVLK 242
                         250       260
                  ....*....|....*....|....*.
gi 1894925283 275 ----------AIAYLRACLNPVLYAF 290
Cdd:cd15121   243 aaklarpnvtALAFLSSSVNPVLYAF 268
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
38-299 1.90e-22

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 94.83  E-value: 1.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSM 117
Cdd:cd15923     7 YIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSYRRESAGLQKLCNFVLSLYYINMYVSI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 118 LILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNvfNLDKLICGYH-DEAISTVVLATQM 196
Cdd:cd15923    87 FTITAISVDRYVAIRYPLRARELRSPRKAA--VVCAVIWVLVVTISIPYFLLDS--SNEKTMCFQRtKQTESLKVFLLLE 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 197 TLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSL--KIIFLVMA---VFLLTQMPFNLM---KFIRSTHWEYYAMTSFHY 268
Cdd:cd15923   163 IFGFLLPLIIMTFCSARVIHTLQKRLDDVGSRSEtkQCIRVIMAnliVFIVCFLPVHVGffvKFIVGKSYSCDSKLIIHF 242
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1894925283 269 TIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15923   243 FLQSAFCLSDMNCCLDAFCYYFATKEFREAY 273
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
33-291 1.91e-22

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 95.15  E-value: 1.91e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVIsiFYHKLQSLTD---VFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLG 107
Cdd:cd15376     2 FLWPILGVEFLVAVLGNGLALWL--FVTRERRPWHtgvVFSFNLAVSDLLYALSLPLLAayYYPPKNWRFGEAACKLERF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 108 IYTINFYTSMLILTCITVDRFIVVVKATkaYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNV-----FNLDKLICGY 182
Cdd:cd15376    80 LFTCNLYGSIFFITCISLNRYLGIVHPF--FTRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLeverhNKTECLGTAV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 183 HDEAIS----TVVLAtqmTLGFFLPLLTMIVCYSVIIKTLLHAGGF---QKHRSLKIIFLVMAVFLLTQMPFNLMK---- 251
Cdd:cd15376   158 DSRLPTylpySLFLA---VVGCGLPFLLTLASYLAIVWAVLRSPGIttlEKRKVAALVAVVVALYAVSFVPYHILRnlnl 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 252 FIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFV 291
Cdd:cd15376   235 YRRLQWLKAAASLRIYFAYQVTKGLVTLNMCIHPLLYMAV 274
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
38-299 1.94e-22

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 95.19  E-value: 1.94e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF--VCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd14992     7 LVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMalFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIY------GNVFNLDKLICG---YHDEA 186
Cdd:cd14992    87 SSLTLTAIAFDRYFAIIHPLKPRHRQSYTTT--VIIIITIWVVSLLLAIPQLYYattevlFSVKNQEKIFCCqipPVDNK 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMTLG-FFLPLLTMIVCYSVIIKTL-------------LHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKF 252
Cdd:cd14992   165 TYEKVYFLLIFVViFVLPLIVMTLAYARISRELwfrkvpgfsikevERKRLKCKRRVIKMLVCVVVLFVICWLPFHLFFL 244
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1894925283 253 IRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14992   245 LRDFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
38-299 2.39e-22

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 95.11  E-value: 2.39e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPFWAYAGIH--EWVFGQVMCKSLLGIYTINFY 114
Cdd:cd14979     7 YVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLlILLVGLPVELYNFWWqyPWAFGDGGCKLYYFLFEACTY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYH----------D 184
Cdd:cd14979    87 ATVLTIVALSVERYVAICHPLKAKTLVTKRRV--KRFILAIWLVSILCAIPILFLMGIQYLNGPLPGPVpdsavctlvvD 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVLATQMTLGFFLPLLTMIVCYSVI--------IKTLLHAGGFQKHRSL-----------KIIFLVMAVFLLTQM 245
Cdd:cd14979   165 RSTFKYVFQVSTFIFFVLPMFVISILYFRIgvklrsmrNIKKGTRAQGTRNVELslsqqarrqvvKMLGAVVIAFFVCWL 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1894925283 246 PFNLMK--FIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14979   245 PFHAQRlmFSYASKEDTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
33-297 4.45e-22

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 94.05  E-value: 4.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd14991     2 ILPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIdyYLRGEHWIFGEAWCRVNLFMLS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGkvTSLLIWVISLLVSLPQIIYGN-VFNLDKLIC----GYHDE 185
Cdd:cd14991    82 VNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAG--VAGLLWALVLLLTLPLLLSTLlTVNSNKSSChsfsSYTKP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKH----RSLKIIFLVMAVFLLTQMP---FNLMKFIRSTHW 258
Cdd:cd14991   160 SLSIRWHNALFLLEFFLPLGLIVFCSVRIACNLRIRQSLGKQarvqRAIRLVFLVVIVFVLCFLPsiiAGLLALVFKNLG 239
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1894925283 259 EYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd14991   240 SCRCLNSVAQLFHISLAFTYLNSALDPVIYCFSSPWFRN 278
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-299 5.84e-22

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 93.88  E-value: 5.84e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGlVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPF-WAYAGIHE--WVFGQVMCKSLLGIYTINFY 114
Cdd:cd15204     9 LIMLVCG-VGNLLLIAVLARYKKLRTLTNLLIANLALSDfLVAVFCLPFeMDYYVVRQrsWTHGDVLCAVVNYLRTVSLY 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVkatkayNQQAKRMTWGK--VTSLLIWVISLLVSLPQIIYGNVF---NLDKLICG----YHDE 185
Cdd:cd15204    88 VSTNALLVIAIDRYLVIV------HPLKPRMKRRTacVVIALVWVVSLLLAIPSAVYSKTTpyaNQGKIFCGqiwpVDQQ 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAG--GFQKH----------RSLKIIFLVMAVFLLTQMPFNLMKFI 253
Cdd:cd15204   162 AYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRvpGQQTEqirrrlrrrrRKVRLLVVILTAFVLCWAPYYGYAIV 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1894925283 254 RSTHWEYYAMTSFHYTIM-VTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15204   242 RDFFPTLLSKEKLNTTIFyIVEALAMSNSMINTVVYVAFNNNIRKYL 288
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
35-299 6.16e-22

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 94.03  E-value: 6.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  35 PCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCT-LPFWAYAGI-HEWVFGQVMCKSLLGIYTIN 112
Cdd:cd14977     4 MSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLcVPLNAYNLLtKDWLFGDVMCKLVPFIQVTS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVtsLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAISTVVL 192
Cdd:cd14977    84 LGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKL--AVIWVGSVLLAVPEAVLSTVARESSLDNSSLTVCIMKPST 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 193 ATQMT-----------LGFFLPLLTMIVCYSVIIKTLLHAGGF----------QKHRSLKIIFLVMAVFLLTQMPFNLMK 251
Cdd:cd14977   162 PFAETypkarswwlfgCYFCLPLAFTAVCYLLMARTLIRAAKEytrgtkkhmkQRRQLAKTVLCLVLVFAFCWLPEHISN 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1894925283 252 FIRSTHWEYYAMTSFHYTIMVTEA---IAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14977   242 ILRATLYNEVLIDTRSTLDILDLIgqfLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
38-299 8.78e-22

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 93.61  E-value: 8.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGIHE-WVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15208     7 YILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADfLVIIICLPATLLVDVTEtWFFGQVLCKIIPYLQTVSVSV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKaYNQQAKRmtwGKVTSLLIWVISLLVSLPQIIYGNVFNLDKL--------ICGYH--DE 185
Cdd:cd15208    87 SVLTLSCIALDRWYAICHPLM-FKSTAKR---ARVSILIIWIVSLLIMIPQAIVMECSRVVPLanktilltVCDERwsDS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMTLGFFLPLLTMIVCYSVIIKTL-----------------------LHAGGFQKH---RSLKIIFLVMAV 239
Cdd:cd15208   163 IYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLwcrqipgtssvvqrkwnkprksaVAAEEKQLRsrrKTAKMLIVVVIM 242
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1894925283 240 FLLTQMPFNLMKFIRSTHWEYYAMTSFHYTI-MVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15208   243 FAICYLPVHLLNILRYVFGLFTVDRETIYAWfLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
32-299 2.85e-21

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 91.76  E-value: 2.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGI--HEWVFGQVMCKSLLGIY 109
Cdd:cd15364     1 IFLVVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSnnHKWPWGSLACKITGYIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICgyHDEAIST 189
Cdd:cd15364    81 FCNIYISILLLCCISIDRFVAVVYALESRGRRRQRI--AAFISFLIFIVVGLVHSPVFIMREGQTEGSHTC--FETLQMD 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLA----TQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAV---FLLTQMPFNLMKFIRSTHWEYY- 261
Cdd:cd15364   157 TQVAgfyyARFCIGFAIPLAILIFTNYRIFRSIQTSTSLTPHQKAKVKYLAIAViviFLICFAPYHLVLLVRAIAFSLYp 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1894925283 262 -AMTSFHYTIMVTEAI----AYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15364   237 nGMCGFEERIYTPSVIflclSTVNSVADPIIYVLVSENVRQDI 279
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
39-297 4.32e-21

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 90.79  E-value: 4.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCT-LPFWAYAGIH-EWVFGQVMCKSLLGIYTINFYTS 116
Cdd:cd15210     8 IVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFnLPLAASTFLHqAWIHGETLCRVFPLLRYGLVAVS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 117 MLILTCITVDRFIVVVKaTKAYNQQAKRMtWGKVTSLLIWVISLLVSLPQI-IYGNVFNLDKLI--CGYHDEAISTVVLA 193
Cdd:cd15210    88 LLTLVLITLNRYILIAH-PSLYPRIYTRR-GLALMIAGTWIFSFGSFLPLWlGIWGRFGLDPKVcsCSILRDKKGRSPKT 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 194 TQMTLGFFLPLLTMIVCYSVIiktllhaggfQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRsthweyyAMTSFHYTIMVT 273
Cdd:cd15210   166 FLFVFGFVLPCLVIIICYARR----------EDRRLTRMMLVIFLCFLVCYLPITLVNVFD-------DEVAPPVLHIIA 228
                         250       260
                  ....*....|....*....|....
gi 1894925283 274 EAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15210   229 YVLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
32-297 5.23e-21

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 91.09  E-value: 5.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPF--WAYAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15379     1 VLLPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLliYNYTQKDYWPFGDFTCRLVRFQF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQ-AKRMTWgkVTSLLIWVISLLVSLPQIIYGNV-FNLDKLIC-GYHDEA 186
Cdd:cd15379    81 YTNLHGSILFLTCISVQRYLGICHPLASWHKKkGKKLTW--LVCGAVWLVVIAQCLPTFVFASTgTQRNRTVCyDLSPPA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMTL---GFFLPLLTMIVCY---------SVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIR 254
Cdd:cd15379   159 RSTAYFPYGITLtrtGFLLPFAARLACYcsmatilcrVVIAVAVVAAPGEKRGKAARMIIVVAAVFLISFLPFHYTKTRY 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1894925283 255 STHWEYYAM-----TSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15379   239 LQVRSWDGGpcttrQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRP 286
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
32-297 5.96e-21

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 91.01  E-value: 5.96e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYagIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15920     1 VTLPVMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRVA--YQNTAGPLSFCKIVGAFFYL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKrmTWGKVTSLLIWVISLLVSLPQII-YGNVFNLDKLICGYHDEAISTV 190
Cdd:cd15920    79 NMYASILFLSLISLDRYLKIIKPLQQFKIHTV--PWSSAASGGVWLLLLACMIPFLFeSRNEGPCDNKCFHFRSKGLTAG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKH--------RSLKIIFLVMAVFLLTQMPFNL---------MKFI 253
Cdd:cd15920   157 GINLTAVVIFYILSLLFLYFYAKISHKLYKVSLGNAQqqikkaskRAIIKTFIVLAIFIVCFVPYHIvrvpyvlaqIDVI 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1894925283 254 RSTHWEYYamtsFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15920   237 SSLPWKQT----LHIANELVLCLSALNSCLDPIIYFFLSSSFRR 276
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
32-299 6.01e-21

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 91.38  E-value: 6.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCmYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV--FVCtLPFWAYAGI-HEWVFGQVMCKSLLGI 108
Cdd:cd15205     2 AFVIT-YVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLitFFC-IPFTLLQNIsSNWLGGAFMCKMVPFV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTslLIWVISLLVSLP-------QIIYGNVFNLDKLIC- 180
Cdd:cd15205    80 QSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLG--LVWIVSVIVGSPmlfvqqlEVKYDFLYEKRHVCCl 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 181 -GYHDEAISTVVLATQMTLGFFLPLLTMIVCYSVI-----IK-------TLLHAGGFQ-------KHRSLKIIFLVMAVF 240
Cdd:cd15205   158 eRWYSPTQQKIYTTFILVILFLLPLTTMLFLYSRIgyelwIKkrvgdasVLQTIHGIEmskisrkKKRAVKMMVTVVLLF 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1894925283 241 LLTQMPFNLMKFIR--STHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15205   238 AVCWAPFHVVHMMIeySNLENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
32-299 6.19e-21

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 91.04  E-value: 6.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKL-QSLTDVFLVNLPLADLVF-VCTLPFWAYA-GIHEWVFGQVMCKSLLGI 108
Cdd:cd15097     1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFiLFCVPFQATIySLEGWVFGSFLCKAVHFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGNVFNLDKL-IC--GYHDE 185
Cdd:cd15097    81 IYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRN--AVAAIALIWGLSLLFAGPYLSYYDLIDYANStVCmpGWEEA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATqMTLGFFLPLLTMIVCYSVIIKTLLHAGG---------FQKHRSLKIIFLVMAVFLLTQMPFNLMkfIRST 256
Cdd:cd15097   159 RRKAMDTCT-FAFGYLIPVLVVSLSYTRTIKYLWTAVDpleamseskRAKRKVTKMIIIVTALFCLCWLPHHVV--ILCY 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1894925283 257 HWEYYAMTSFHYTI-MVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15097   236 LYGDFPFNQATYAFrLLSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
33-296 1.31e-20

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 89.88  E-value: 1.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLV-VFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd14989     1 FLSCLYTIfLFPIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLIEVFNLNEKYYDIAVLCTFMSLFLQI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDeaiSTVV 191
Cdd:cd14989    81 NMYSSIFFLTWMSFDRYIALAKVMKS--SPLRTMQHARLSCGLIWMASISATLLPFTAVQAQHTGEVHFCFAD---VREI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 LATQMTLGFFLPLLTMIVCYSVIIKTLLHAggfQKHRS--------LKIIFLVMAVFLLTQMPFNLMKFIR--------- 254
Cdd:cd14989   156 QWLEVTLGFIIPFSIIGLCYSLIVRVLVRA---QKHRRlrprrqkaLRMILVVVLVFFICWLPENVFISIQllqgtqeps 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1894925283 255 ----STHWEYYAMTSFhytimVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd14989   233 esydESFRHNHPLTGH-----IVNLAAFSNSCLNPLIYSFLGETFR 273
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
32-299 2.07e-20

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 89.66  E-value: 2.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVIsIFYHK-LQSLTDVFLVNLPLADLV--FVCTLPFWAYAGIHEWVFGQVMCK--SLL 106
Cdd:cd15390     1 VLWSIVFVVMVLVAIGGNLIVIWI-VLAHKrMRTVTNYFLVNLAVADLLisAFNTVFNFTYLLYNDWPFGLFYCKfsNFV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 107 GIYTInfYTSMLILTCITVDRFIVVVKATKaynqqaKRM--TWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKL------ 178
Cdd:cd15390    80 AITTV--AASVFTLMAISIDRYIAIVHPLR------PRLsrRTTKIAIAVIWLASFLLALPQLLYSTTETYYYYtgsert 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 179 --ICGYHDEAISTVVLATQ---MTLGFFLPLLTMIVCYSVIIKTLLHAGGF------------QKHRSLKIIFLVMAVFL 241
Cdd:cd15390   152 vcFIAWPDGPNSLQDFVYNivlFVVTYFLPLIIMAVAYTRVGVELWGSKTIgentprqlesvrAKRKVVKMMIVVVVIFA 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1894925283 242 LTQMPFNLMKFIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15390   232 ICWLPYHLYFILTYLYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
37-297 2.77e-20

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 89.31  E-value: 2.77e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCT-LPFWAYAG-IHEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15083     6 FILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILnCPLMVISSfSGRWIFGKTGCDMYGFSGGLFGI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVtsLLIWVISLLVSLPQIIYGNVFNLDKL--ICGYHDEAISTVVL 192
Cdd:cd15083    86 MSINTLAAIAVDRYLVITRPMKASVRISHRRALIVI--AVVWLYSLLWVLPPLFGWSRYVLEGLltSCSFDYLSRDDANR 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 193 ATQMTL---GFFLPLLTMIVCYSVII---------------KTLLHAGGFQKHRS------LKIIFLVMAVFLLTQMPFN 248
Cdd:cd15083   164 SYVICLlifGFVLPLLIIIYCYSFIFravrrhekamkemakRFSKSELSSPKARRqaevktAKIALLLVLLFCLAWTPYA 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1894925283 249 LMKFIrstHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15083   244 VVALI---GQFGYLEVLTPLATAIPAAFAKTSAIYNPVIYAFSHPKFRR 289
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
32-291 2.98e-20

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 89.08  E-value: 2.98e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE--WVFGQVMCKSLLGIY 109
Cdd:cd15366     1 LFPPTLYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRdnWIHGPESCKLFGFIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNlDKLICGYHDEAIST 189
Cdd:cd15366    81 YTNIYISIAFLCCISVDRYLAVAHPLRF--AKVRRVKTAVAVSAVVWAIEIGANSAPLFHDELFR-DRYNHTFCFEKYPM 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTL-----GFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVM---AVFLLTQMPFNLMKFIRST----- 256
Cdd:cd15366   158 EDWVAWMNLyrvfvGFLFPWVLMLFSYRGILRAVRGNVSTEQQEKAKIKRLALsliAIVLLCFAPYHVLLLSRSVvylgk 237
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1894925283 257 ----HWEYYAMTSFHytimVTEAIAYLRACLNPVLYAFV 291
Cdd:cd15366   238 pcdcGFEERVFTAYH----VSLALTSLNCVADPILYCLV 272
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
38-299 4.05e-20

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 88.69  E-value: 4.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKlQSLTDVFLVNLPLADLVFVCTLPFWAYAGI--HEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15120     7 LFVTFLVGLVVNGLYLWVLGFKMR-RTVNTLWFLHLILSNLIFTLILPFMAVHVLmdNHWAFGTVLCKVLNSTLSVGMFT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATkaYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLD--KLICgYHDEAISTVVLA 193
Cdd:cd15120    86 SVFLLTAISLDRYLLTLHPV--WSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRLDEkgKTIC-QNNYALSTNWES 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 194 TQMT----------------LGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNL---MKFIR 254
Cdd:cd15120   163 AEVQasrqwihvamfvfrflLGFLLPFLIITFCYVRMALKMKERGLARSSKPFKVMFTAVVSFFVCWLPYHLhsgLVLTR 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1894925283 255 STHweyyaMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15120   243 GRP-----PSLTDITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
32-290 4.69e-20

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 88.71  E-value: 4.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVIsIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAY--AGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15118     1 VATICLHGIVSTLGIVENLLILWV-VGFRLRRTVISIWILNLALSDLLATLSLPFFTYylASGHTWELGTTFCRIHSSIF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNVFNL-DKLICGYHDEAI- 187
Cdd:cd15118    80 FLNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAK--KICGVIWAMALINTIPYFVFRDVIERkDGRKLCYYNFALf 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 --------------STVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFI 253
Cdd:cd15118   158 spspdnnhpickqrQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRRPGRFVRLVVSVVVSFALCWAPYHIFSII 237
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1894925283 254 RS-THWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAF 290
Cdd:cd15118   238 EVmAHNQHSLRPLVIQGLPFATTLAFLNSVLNPVLYVF 275
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
32-297 4.90e-20

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 88.55  E-value: 4.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVC-TLPFWAYAGI-HEWVFGQVMCKSLLGIY 109
Cdd:cd15389     1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLlNTPFTLVRFVnSTWVFGKIMCHLSRFAQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAynqqakRMTW--GKVTSLLIWVISLLVSLPQIIYGNVFNLD------KLIC- 180
Cdd:cd15389    81 YCSVYVSTLTLTAIALDRHRVILHPLKP------RITPcqGVVVIAIIWIMASCLSLPHAIYQKLVEFEysnertRSRCl 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 181 ----GYHDEAISTVVLATQMTLgFFLPLLTMIVCYSVIIKTL-------------LHAGGFQKHRSLKIIFLVMAVFLLT 243
Cdd:cd15389   155 psfpEPSDLFWKYLDLATFILQ-YVLPLLIIGVAYTRVAKKLwlrnaigdvtteqYVAQRRKKKKTIKMLMLVVLLFAIC 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1894925283 244 QMPFNLMKFIRSTHWEYY---AMTSFHYTIMVTeaiaylrACLNPVLYAFVSLKFRK 297
Cdd:cd15389   234 WLPLNCYHVLLSSHPIRSnsaLFFAFHWLAMSS-------TCYNPFIYCWLNDSFRS 283
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
45-299 7.20e-20

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 87.94  E-value: 7.20e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  45 GLVGNSLVlVISIFYH---KLQSLTDVFLVNLPLADLVFVCTLPFW-AYAGIHEWVFGQVMCKSLLGIYTINFYTSMLIL 120
Cdd:cd15122    14 GLPGNGFI-IWSILWKmkaRGRSVTCILILNLAVADGAVLLLTPFFiTFLTRKTWPFGQAVCKAVYYLCCLSMYASIFII 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 121 TCITVDRFIVVVKATKAYNQQAKRMtwgkVTSLL--IWVISLLVSLPQIIYGNVFNLDKL---IC-GYHDEAISTVVLAT 194
Cdd:cd15122    93 GLMSLDRCLAVTRPYLAQSLRKKAL----VRKILlaIWLLALLLALPAFVYRHVWKDEGMndrICePCHASRGHAIFHYT 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 195 QMTL-GFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTH--WEYYAMTSFHYTIM 271
Cdd:cd15122   169 FETLvAFVLPFGVILFSYSVILVRLKGARFRRRARVEKLIAAIVVAFALLWVPYHVVNLLQVVAnlAPGEVLEKLGGAAK 248
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1894925283 272 V----TEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15122   249 AaragATALAFFSSSVNPLLYVFAAGDLIKTS 280
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-296 1.13e-19

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 87.55  E-value: 1.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPF-----WAYagiHEWVFGQVMCKSLLGIYTINF 113
Cdd:cd15132     8 LILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFdlyrlWKS---RPWIFGEFLCRLYHYISEGCT 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLP-------QIIYGNVFNLDKLICGYHDEA 186
Cdd:cd15132    85 YATILHITALSIERYLAICFPLRAKVLVTRRRV--KCVIAALWAFALLSAGPflflvgvEQDNNIHPDDFSRECKHTPYA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQM---TLGFFLPLLTMIVCYSVIIKTLLH----------AGGFQKHR-SLKIIFLVMAVFLLTQMPFNLMKF 252
Cdd:cd15132   163 VSSGLLGIMIwvtTTYFFLPMLCLSFLYGFIGRKLWKskndlrgpnaAARERSHRqTVRILAVVVLAFIICWLPFHIGRI 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1894925283 253 IRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15132   243 LFANTEDYRTMMFSQYFNIVAMQLFYLSASINPILYNLISRKYR 286
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
36-295 4.55e-19

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 85.39  E-value: 4.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVCGLVGNSLVLviSIFYHKLQSLTD--VFLVNLPLADLVFVCTLPFWAYAGIHEWVfGQVMCKSLLGIYTINF 113
Cdd:cd15164     5 IIYIPILFFGLLFNVLAL--WVFCCKMKKWTEtrVYMINLAVADCCLLFSLPFVLYFLKHSWP-DDELCLVLQSIYFINR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISL-LVSLPQI--IYGNVFNLDKlicGYHDEAISTV 190
Cdd:cd15164    82 YMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKA--ALTCGLLWVLVIiSVSLRLAweEQEENFCFGK---TSTRPSKRTL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLAtqmTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKH------RSLKIIFLVMAVFLLTQMPFNLMKFIR----STHWEY 260
Cdd:cd15164   157 IFS---LLGFFIPLIILSFCSIQVIRSLKKKKKTNPHeekliqKAIYIVSANLIVFIVCFLPLHIGLLVRfvmeSNKASC 233
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1894925283 261 YAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKF 295
Cdd:cd15164   234 SLIQNIRNFIYVASCLANANCCLDAICYYFVAKEF 268
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
35-292 5.33e-19

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 85.60  E-value: 5.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  35 PCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE--WVFGQVMCKSLLGIYTIN 112
Cdd:cd15365     4 PFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGdnWTLSGFVCIFSAFLLYTN 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNVFN--------LDKLICGYHD 184
Cdd:cd15365    84 FYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTA--LSVSVAIWLLEICFNAVILTWEDSFHessshtlcYDKFPLEDWQ 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVvlatQMTLGFFLPLLTMIVCYSVIIKTLLHAGGF---QKHRSLKIIFLVMAVFLLTQMPFNLMKFIRST--HWE 259
Cdd:cd15365   162 ARLNLF----RICLGYLLPLLIILFCYWKIYQAVRSNQATedqEKKKIFKLLLLITVTFVICFTPYHVVLLIRSIvePCD 237
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1894925283 260 YYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVS 292
Cdd:cd15365   238 CRNAKWLYTLYKITVALTSLNCIADPFLYCFVT 270
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
37-299 6.67e-19

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 84.70  E-value: 6.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPFWAYAGIH--EWVFGQVMCKSLLGIYTINF 113
Cdd:cd15053     6 FLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLlVAILVMPFAVYVEVNggKWYLGPILCDIYIAMDVMCS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPqIIYG--NVFNLDKLICGYHDEA---IS 188
Cdd:cd15053    86 TASIFNLCAISIDRYIAVTQPIKYARQKNSKRVL--LTIAIVWVVSAAIACP-LLFGlnNVPYRDPEECRFYNPDfiiYS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVlatqmtlGFFLPLLTMIVCYSVIIKTLLhaggfQKHRSLKIIFLVMAVFLLTQMPF---NLMKFIRSTHWEYYAMTS 265
Cdd:cd15053   163 SIS-------SFYIPCIVMLLLYYRIFRALR-----REKKATKTLAIVLGVFLFCWLPFftlNILNAICPKLQNQSCHVG 230
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1894925283 266 FHYTIMVTeAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15053   231 PALFSLTT-WLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
33-297 8.17e-19

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 85.18  E-value: 8.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVcGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCT-LPF-WAYAGIHE-WVFGQVMCKSLLGIY 109
Cdd:cd15394     3 IIPLYSLVVLV-GVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATcVPLtLAYAFEPRgWVFGRFMCYFVFLMQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKaynqqaKRMTWGKVTSLL--IWVISLLVSLPQII---YGNVFNLDKLICG--- 181
Cdd:cd15394    82 PVTVYVSVFTLTAIAVDRYYVTVYPLR------RRISRRTCAYIVaaIWLLSCGLALPAAAhtyYVEFKGLDFSICEefw 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 182 YHDEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLH-------------AGGFQKHRSLKIIFLVMAVFLLTQMPFN 248
Cdd:cd15394   156 FGQEKQRLAYACSTLLITYVLPLLAISLSYLRISVKLRNrvvpgsmtqsqaeWDRARRRKTFRLLVVVVVAFAICWLPLH 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1894925283 249 LMKFIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15394   236 IFNVIRDIDIDLIDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFRG 284
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
38-299 1.01e-18

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 85.07  E-value: 1.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNsLVLVISIFYHK-LQSLTDVFLVNLPLADLVF-VCTLPFWAYAGIHE--WVFGQVMCKslLGIYTINF 113
Cdd:cd15134     7 YGIIFVTGVVGN-LCTCIVIARNRsMHTATNYYLFSLAVSDLLLlILGLPFELYTIWQQypWVFGEVFCK--LRAFLSEM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 --YTSMLILTCITVDRFIVVVKATKAYN----QQAKRMTwgkvtsLLIWVISLLVSLPQIIYGNVFNL-----------D 176
Cdd:cd15134    84 ssYASVLTITAFSVERYLAICHPLRSHTmsklSRAIRII------IAIWIIAFVCALPFAIQTRIVYLeypptsgealeE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 177 KLICGY-HDEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTL------------LHAGGFQKHRSLKIIFLVMAV---F 240
Cdd:cd15134   158 SAFCAMlNEIPPITPVFQLSTFLFFIIPMIAIIVLYVLIGLQLrrstllrrgqrsVSGGRRSSQSRRTVLRMLVAVvvaF 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1894925283 241 LLTQMPFNLMKFIRSTHWEYYAMTSFHYTIM--VTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15134   238 FICWAPFHAQRLLTVYAKNMTPPYLFINRILfyISGVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
39-299 1.15e-18

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 84.29  E-value: 1.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLvFVCTL--PFWAYAGIHE--WVFGQVMCksLLGIYTINFY 114
Cdd:cd15052     8 LLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADL-LVGLLvmPLSILTELFGgvWPLPLVLC--LLWVTLDVLF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLI--LTCITVDRFIVVVKATKAYNQQAKRMTWGKVTslLIWVISLLVSLPQIIYG-----NVFNldKLICGYHDEAI 187
Cdd:cd15052    85 CTASImhLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIA--IVWLISIGISSPIPVLGiidttNVLN--NGTCVLFNPNF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 stVVLATQMTlgFFLPLLTMIVCYSVIIKTLLhaggfQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSfH 267
Cdd:cd15052   161 --VIYGSIVA--FFIPLLIMVVTYALTIRLLS-----NEQKASKVLGIVFAVFVICWCPFFITNILTGLCEECNCRIS-P 230
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1894925283 268 YTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15052   231 WLLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
39-299 1.56e-18

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 83.94  E-value: 1.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLV---GNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGI--HEWVFGQVMCKSLLGIYTIN 112
Cdd:cd15067     4 VVLSLFCLVtvaGNLLVILAVLRERYLRTVTNYFIVSLAVADlLVGSIVMPFSILHEMtgGYWLFGRDWCDVWHSFDVLA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTslLIWVISLLVSLPQIIY---GNVFNLDKLICGYHDeaiST 189
Cdd:cd15067    84 STASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIA--LVWICSALISFPAIAWwraVDPGPSPPNQCLFTD---DS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTLGFFLPLLTMIVCYSVIIKTLLHaggfqKHRSLKIIFLVMAVFLLTQMPF----NLMKFIRSTHWEYyamts 265
Cdd:cd15067   159 GYLIFSSCVSFYIPLVVMLFTYYRIYRAAAK-----EQKAAKTLGIVMGVFILCWLPFfvtnILIGFCPSNCVSN----- 228
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1894925283 266 FHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15067   229 PDILFPLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
32-299 3.49e-18

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 83.51  E-value: 3.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV--FVCTLPFWAYAGIHEWVFGQVMCKSLLGI- 108
Cdd:cd15048     1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLvgLVSMPFYIPYTLTGKWPFGKVFCKAWLVVd 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINfYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVtsLLIWVISLLVSLPQIIYGNVFNLDKLI----C--GY 182
Cdd:cd15048    81 YTLC-TASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLM--ALVWILAFLLYGPAIIGWDLWTGYSIVptgdCevEF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 183 HDEAISTVVLAtqmTLGFFLPLLTMIVCYSVI---------------------------IKTLLHAGGFQKHRSL-KIIF 234
Cdd:cd15048   158 FDHFYFTFITS---VLEFFIPFISVSFFNLLIylnirkrsrrrplrsvpilpasqnpsrARSQREQVKLRRDRKAaKSLA 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1894925283 235 LVMAVFLLTQMPFNLMKFIRSThWEYYAMTSFHYTImvTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15048   235 ILVLVFLICWAPYTILTIIRSF-CSGSCVDSYLYEF--TFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
37-299 3.62e-18

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 82.94  E-value: 3.62e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPFWAYAGIHE-WVFGQVMCKSLLGIYTINFY 114
Cdd:cd15979     6 LYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLmLAVFCMPFTLIPNLMGtFIFGEVICKAVAYLMGVSVS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSllIWVISLLVSLPQIIYGNVFNLDK------LICGY-----H 183
Cdd:cd15979    86 VSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAA--TWLLSGLIMIPYPVYSVTVPVPVgdrprgHQCRHawpsaQ 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 184 DEAISTVVLatqMTLGFFLPLLTMIVCYSVIIKTlLHAGGFQKHRSLKIIFLVMAVFLLTQMPFnlmkFIRSThWEYYAM 263
Cdd:cd15979   164 VRQAWYVLL---LLILFFIPGVVMIVAYGLISRE-LYRGLLAKKRVIRMLVVIVAMFFLCWLPI----FSANT-WRAFDP 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1894925283 264 TSFHYT-----IMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15979   235 LSAHRAlsgapISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
39-297 3.86e-18

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 83.23  E-value: 3.86e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCT-LPFWAYAGIH-EWVFGQVMCK------SLLGIyt 110
Cdd:cd15336     8 LIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTqSPIFFVNSLHkRWIFGEKGCElyafcgALFGI-- 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 infyTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNVFNLDKLI--CGYHDEAIS 188
Cdd:cd15336    86 ----TSMITLLAISLDRYLVITKPLASIRWVSKKRA--MIIILLVWLYSLAWSLPPLFGWSAYVPEGLLtsCTWDYMTFT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLATQMTLG---FFLPLLTMIVCYSVIIKTLLHAG------GFQKHRSL--------------KIIFLVMAVFLLTQM 245
Cdd:cd15336   160 PSVRAYTMLLFcfvFFIPLGIIIYCYLFIFLAIRSTGrevqklGSQDRKEKakqyqrmknewkmaKIAFVVILLFVLSWS 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1894925283 246 PFNLMKFIRsthWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15336   240 PYACVALIA---WAGYAHLLTPYMKSVPAVIAKASAIYNPIIYAITHPKYRE 288
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
36-299 5.32e-18

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 82.86  E-value: 5.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV--FVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINF 113
Cdd:cd15000     4 SMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLtlLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRF--IVVVKATKAYNQQAKrmtwgkVTSLLIWVISLLVSLPQIIYGNV-----FNLDKLICGyHDEA 186
Cdd:cd15000    84 LASVLALCAVSYDRLtaIVLPSEARLTKRGAK------IVIVITWIVGLLLALPLAIYRSYrerqwKNFLETYCA-ENTQ 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMTLGFFLPLLTMIVCYSVII-------KTLLHAGGFQ----KHRSLKIIFLVMAVFLLTQMPFNLMKFIR- 254
Cdd:cd15000   157 VLPIYWHVIITVLVWLPLGIMLICYSAIFwkldkyeRRVLRREHPSvvryKKKAAKTLFIVLITFVVCRIPFTALIFYRy 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1894925283 255 ----STHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15000   237 klvpNDNTQNSVSGSFHILWFASKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
34-297 6.64e-18

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 82.43  E-value: 6.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15148     3 LAVFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRIlyHVNNNQWTLGPLLCKVVGNLFYM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKayNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHD--EAIST 189
Cdd:cd15148    83 NMYISIILLGFISLDRYLKINRSSR--RQKFLTRKWSIVACGVLWAVALVGFVPMIVLTEKNEESTKCFQYKDrkNAKGK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAG--------GFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHW--- 258
Cdd:cd15148   161 AIFNFLIVAMFWLVFLLLILSYGKIAKKLLRISrdkpdfpnAAKYNRTARKSFFVLFIFTVCFVPYHAFRIFYITSQlqn 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 259 -EYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15148   241 nSCYWKEILHKTNEIMLLLSAFNSCLDPVMYFLLSSSIRK 280
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
34-299 7.08e-18

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 82.69  E-value: 7.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCT-LPFWAYAG-IHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15125     3 IPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASRYfYEEWMFGTVGCKLIPVIQLT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLicgyhDEAISTVV 191
Cdd:cd15125    83 SVGVSVFTLTALSADRYKAIVNPMDI--QTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPD-----DNTTFTAC 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 LATQMT--------------LGFFLPLLTMIVCYSVIIKTLLHA-----GGFQKH---------RSLKIIFLVMAVFLLT 243
Cdd:cd15125   156 IPYPQTdemhpkihsvliflVYFLIPLAIISIYYYHIAKTLIKSahnipGEYSEHskrqmetrkRLAKIVLVFVGLFAFC 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1894925283 244 QMPFNLMKFIRSTHWEYYAMTSFHYTI-MVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15125   236 WFPNHVLYMYRSFNYNEIDSSLGHMIVtLVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
38-301 7.85e-18

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 82.31  E-value: 7.85e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVIsiFYHKLQSL---TDVFLVNLPLADLVFVCTLPF---WAYAGIHeWVFGQVMCKSLLGIYTI 111
Cdd:cd15170     7 YIITFLIGLPANLLAFYT--FIRKVRRKptpIDILLLNLTVSDLIFLLFLPFkmaEAASGMI-WPLPYFLCPLSSFIFFS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKaYNQQaKRMTWGKVTSLLIWVISLL-VSLPQII-----YGNVFNLDKLICgYHD- 184
Cdd:cd15170    84 TIYISTLFLTAISVERYLGVAFPIK-YKLR-RRPLYAVIASVFFWVLAFShCSIVYIVeyhidSENTSVTNNSRC-YDNf 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 -EAISTVVLATQMTLG---FFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLV---MAVFLLTQMPFN---LMKFI- 253
Cdd:cd15170   161 tPEQLKILLPVRLELFlvlFCIPFLITCFCYINFIRILSSLPHISRQRKQRAIGLAvatLLNFIVCFAPYNishVVGFIq 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1894925283 254 -RSTHWEYYAMTsfhytimvteaIAYLRACLNPVLYAFVSLKFRKNFWK 301
Cdd:cd15170   241 rKSPEWRMYALL-----------LSTLNACLDPIIFYFSSSAVRRAFKE 278
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
38-296 1.14e-17

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 81.77  E-value: 1.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPF-----WAYagiHEWVFGQVMCKSLLGIYTIN 112
Cdd:cd15928     7 CSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLdlyrlWRY---RPWRFGDLLCRLMYFFSETC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNV---------FNLDKLICGYH 183
Cdd:cd15928    84 TYASILHITALSVERYLAICHPLRAKVLVTRGRV--KLLIAVIWAVAIVSAGPALVLVGVehiqgqqtpRGFECTVVNVS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 184 DEAISTVVLATQMTlgFFLPLLTMIVCYSVIIKTLLHAGGF----------QKHR-SLKIIFLVMAVFLLTQMPFNLMK- 251
Cdd:cd15928   162 SGLLSVMLWVSTSF--FFVPMVCLSLLYGLIGRALWDRRQRsrtagasrrdNNHRqTVRMLAVIVLAFVLCWLPFHVGRv 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1894925283 252 -FIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15928   240 iFNHSRASTKHLHYVSQYFNLVSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
36-299 1.16e-17

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 82.06  E-value: 1.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWA-YAGIHEWVFGQVMCKSLLGIYTINF 113
Cdd:cd15195     5 LVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVtFFNMPMDAvWNYTVEWLAGDLMCRVMMFLKQFGM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAyNQQAKRmtwGKVTSLLIWVISLLVSLPQIIygnVFNLDKLIC---GYH------- 183
Cdd:cd15195    85 YLSSFMLVVIALDRVFAILSPLSA-NQARKR---VKIMLTVAWVLSALCSIPQSF---IFSVLRKMPeqpGFHqcvdfgs 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 184 --DEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLH-----------------AGGFQ--KHRSLKIIFLVMAVFLL 242
Cdd:cd15195   158 apTKKQERLYYFFTMILSFVIPLIITVTCYLLILFEISKmakrardtpisnrrrsrTNSLEraRMRTLRMTALIVLTFIV 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1894925283 243 TQMPFNLMK-----FIRSTHWEYYAMTSFHYTIMvteaiaYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15195   238 CWGPYYVLGlwywfDKESIKNLPPALSHIMFLLG------YLNPCLHPIIYGVFMKEIRNWI 293
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
32-299 1.39e-17

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 81.53  E-value: 1.39e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVF---LVNLPLADL-VFVCTLPFWAYAGI---HEWVFGQVMCKS 104
Cdd:cd15130     1 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVryhLGSLALSDLlILLLAMPVELYNFIwvhHPWAFGDAGCRG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 105 LLGIYTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTslLIWVISLLVSLPQ-IIYGNVFNLD------K 177
Cdd:cd15130    81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFIS--AIWLASALLAIPMlFTMGLQNESDdgthpgG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 178 LICG-YHDEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAggfqKHRSLKIIFLVMAVFLLTQMPFNLMK----F 252
Cdd:cd15130   159 LVCTpIVDTATLKVVIQVNTFMSFLFPMLVTSILNTVIANKLVQA----LRRGVLVLRAVVIAFVVCWLPYHVRRlmfcY 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1894925283 253 IRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15130   235 ISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVF 281
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
32-297 1.44e-17

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 81.34  E-value: 1.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVIsIFYHKLQSLTDVFLVNLPLADLVFVCTLPF--WAYAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15924     1 QLFPVLYTVIFFAGILLNGLAMWI-FFHIPSKSSFIIYLKNTVVADLLMILTFPFkiLSDAGLGPWQLRTFVCRVTSVLF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNqqAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLI--CGYHDEAI 187
Cdd:cd15924    80 YFTMYTSIVFLGLISIDRYLKIVRPFKTSF--PKSVSFAKILSVVVWALMFLLSLPNMILTNQQPREKNVkkCSFLKSEL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 STV---VLATQMTLGFFLPLLTMIVCYSVIIKTLLHA-------GGFQKHRSLKIIFLVMAVFLLTQMPFNLMK--FIRS 255
Cdd:cd15924   158 GLKwheIVNYICQVIFWIVFLLMIVCYTAITKKVYRSyrrvfrsSSSRRKKSNVKIFIIVAVFFVCFVPYHFARipYTLS 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1894925283 256 ---THWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15924   238 qtrDVFDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRE 282
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
32-299 2.05e-17

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 80.78  E-value: 2.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPFWA-YAGIHEWVFGQVMCksllgiy 109
Cdd:cd15329     1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLlVALLVMPLAIiYELSGYWPFGEILC------- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 tiNFYTSMLILTC---------ITVDRFIVVVKA-TKAYNQQAKRMTwgkVTSLLIWVISLLVSLPQ-IIYGNVFNLDKl 178
Cdd:cd15329    74 --DVWISFDVLLCtasilnlcaISVDRYLVITRPlTYAVKRTPKRMA---LMIAIVWLLSALISIPPlFGWKNKVNDPG- 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 179 ICGYHDEAISTVVlatqMTLG-FFLPLLTMIVCYSVIIKTllhAGGFQK-HRSLKIIflvMAVFLLTQMPFNLMKFIRSt 256
Cdd:cd15329   148 VCQVSQDFGYQIY----ATFGaFYIPLIVMLVLYYKIYRA---AKSERKaIKTLGII---MGAFTLCWLPFFILALLRP- 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1894925283 257 hweYYAMTSFHYTIMVTEAIA----YLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15329   217 ---FLKPIKCSCIPLWLSRLFlwlgYANSFLNPIIYAKFNREFRTPF 260
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
37-296 2.72e-17

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 80.49  E-value: 2.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVcGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGI-HEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15213     7 MILMIFV-GFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLsLVCMPFAAVTIItGRWIFGDIFCRISAMLYWFFVL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYN-QQAKRMTwgkvtsLLIWVISLLVSLPQII----YGNVFNLDKLICGYHDEAIST 189
Cdd:cd15213    86 EGVAILLIISVDRYLIIVQRQDKLNpHRAKILI------AVSWVLSFCVSFPPLVgwgkYEFPPRAPQCVLGYTESPADR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAggfqKHRSLKIIFLVMAVFLLTQMPFNLMKFIrsTHWEYYAmTSFHYT 269
Cdd:cd15213   160 IYVVLLLVAVFFIPFLIMLYSYFCILNTVRSF----KTRAFTTILILFIGFSVCWLPYTVYSLL--SVFSRYS-SSFYVI 232
                         250       260
                  ....*....|....*....|....*..
gi 1894925283 270 IMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15213   233 STCLLWLSYLKSAFNPVIYCWRIKKFR 259
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
35-299 3.45e-17

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 80.19  E-value: 3.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  35 PCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFW-AYAGIHE-WVFGQVMCKSLLGIYTIN 112
Cdd:cd15367     4 PVVYILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWlQYVLQHDnWTYSELLCKICGILLYEN 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAYnqQAKRMTWGKVTSLLIWVISLLVSLPQIIYGnVFNLDK---LIC--GYHDEAI 187
Cdd:cd15367    84 IYISIGFLCCISVDRYLAVVHPFRFH--AFRTMKAATLVSTVIWLKELMTCVFFFLHG-EISKDKenhSVCfeHYPIKAW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 STVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMA---VFLLTQMPFNLMKFIRSThWEY---Y 261
Cdd:cd15367   161 EHNINYYRFYAGFLFPIFLLSFSYCRILRAVRKSHGTQKSQKIQIKRLVLStvvIFLVCFGPYHILLLVRSV-FERdcnF 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1894925283 262 AMTSF---HYTIMVTEaiayLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15367   240 AEGIFnyyHFSLLLTS----FNCVADPVLYCFASESTYHDF 276
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
32-299 3.83e-17

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 80.53  E-value: 3.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPF-WAYAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15393     1 VLLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIgLFSIPFqFQAALLQRWVLPRFMCPFCPFVQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNVF-------NLDKLICGY 182
Cdd:cd15393    81 VLSVNVSVFTLTVIAVDRYRAVIHPLKA--RCSKKSA--KIIILIIWILALLVALPVALALRVEeltdktnNGVKPFCLP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 183 HD------EAISTVVLATQmtlgFFLPLLTMIVCYSVI---IKTLLHAGGFQ----------KHRSLKIIFLVMAVFLLT 243
Cdd:cd15393   157 VGpsddwwKIYNLYLVCVQ----YFVPLVIICYAYTRIavkIWGTKAPGNAQdvrddeilknKKKVIKMLIIVVALFALC 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1894925283 244 QMP---FNLMKFIRST--HWEYYAMTSFhytimVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15393   233 WLPlqtYNLLNEIKPEinKYKYINIIWF-----CSHWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
45-299 4.43e-17

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 79.55  E-value: 4.43e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  45 GLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCT-LPFWAYAGIHE-WVFGQVMCKSLLGIYTINFYTSMLILTC 122
Cdd:cd15325    14 GVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTvLPFSAIFEILGyWAFGRVFCNIWAAVDVLCCTASIMSLCI 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 123 ITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSL-PQIIYGNVFNLDKLICGYHDEAISTVVLATQmtlGFF 201
Cdd:cd15325    94 ISIDRYIGVSYPLRYPSIMTERR--GLLALLCVWVLSLVISIgPLFGWKEPAPEDETICQITEEPGYALFSALG---SFY 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 202 LPLLTMIVCYSVIIKTLLHAGgfQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSThweYYAMTSFHYTIMVTEAIAYLRA 281
Cdd:cd15325   169 LPLAIILVMYCRVYVVALKFS--REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSI---FPAYKPSDTVFKITFWLGYFNS 243
                         250
                  ....*....|....*...
gi 1894925283 282 CLNPVLYAFVSLKFRKNF 299
Cdd:cd15325   244 CINPIIYPCSSQEFKKAF 261
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
32-299 6.58e-17

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 79.89  E-value: 6.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSL---TDVFLVNLPLADL-VFVCTLPFWAYAGI---HEWVFGQVMCKS 104
Cdd:cd15355     1 VLVTAIYLALFVVGTVGNSITLYTLARKKSLQHLqstVHYHLASLALSDLlILLLAMPVELYNFIwvhHPWAFGDAACRG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 105 LLGIYTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQI-----IYGNVFNLDKLI 179
Cdd:cd15355    81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRT--KKFISAIWLASALLAIPMLftmgeQNRSGTHPGGLI 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 180 C-GYHDEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLL-------------HAGGFQ----------KHRSLK---- 231
Cdd:cd15355   159 CtPIVDTSTLKVVIQVNAFLSFLFPMLVISVLNTLIANQLTvmvnqaeqenqvcTIGGQRtvlsvsmepgRVQSLRhgvl 238
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1894925283 232 IIFLVMAVFLLTQMPFNLMK----FIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15355   239 VLRAVVIAFVVCWLPYHVRRlmfcYVSDEQWTTFLYDFYHYFYMLTNVLFYVSSAINPILYNLVSANFRQIF 310
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
37-299 9.35e-17

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 78.63  E-value: 9.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPF-WAYAGIHEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15060     6 LLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLaVAIFVLPLnVAYFLLGKWLFGIHLCQMWLTCDILCCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVvkaTKAYNQQAKRmTWGKVTSL--LIWVISLLVSLPQIIYGNVF---NLDKLICGYHDEAIST 189
Cdd:cd15060    86 ASILNLCAIALDRYWAI---HDPINYAQKR-TLKRVLLMivVVWALSALISVPPLIGWNDWpenFTETTPCTLTEEKGYV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQmtlGFFLPLLTMIVCYsviIKTLLHAGgfQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYT 269
Cdd:cd15060   162 IYSSSG---SFFIPLLIMTIVY---VKIFIATS--KERRAARTLGIIMGVFVVCWLPFFLMYVILPFCETCSPSAKVVNF 233
                         250       260       270
                  ....*....|....*....|....*....|
gi 1894925283 270 IMvteAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15060   234 IT---WLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
38-299 2.13e-16

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 78.42  E-value: 2.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCT-LPFWAYAGIHE-WVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15123     7 YAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIADtWLFGRIGCKLLSFIQLTSVGV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKvtSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEA-----ISTV 190
Cdd:cd15123    87 SVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCK--AGCVWIVSMLFAIPEAVFSDLYSFRDPEKNTTFEAcapypVSEK 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLATQMTLGFFL-----PLLTMIVCYSVIIKTLL--------------HAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMK 251
Cdd:cd15123   165 ILQEIHSLLCFLvfyiiPLSIISVYYFLIARTLYkstfnmpaeehshaRKQIESRKRVAKTVLVLVALFAFCWLPNHILY 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1894925283 252 FIRS-THWEYYAMTSFHYTIMV-TEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15123   245 LYRSfTYHTSVDSSAFHLIATIfSRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
41-296 2.28e-16

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 78.39  E-value: 2.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  41 VFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLP----FWAYagiHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15131    10 LFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLlIFLCMPLdlyrLWQY---RPWNFGDLLCKLFQFVSESCTYS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNVFN------LDKLICGYHDEAIST 189
Cdd:cd15131    87 TILNITALSVERYFAICFPLRAKVVVTKRRV--KLVILVLWAVSFLSAGPIFVLVGVEHengtnpIDTNECKATEYAVRS 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQM---TLGFFLPLLTMIVCYSVIIKTLL-----HAGGFQKHR------SLKIIFLVMAVFLLTQMPFNLMKFIRS 255
Cdd:cd15131   165 GLLTIMVwvsSVFFFLPVFCLTVLYSLIGRKLWrrrreNIGPNASHRdknnrqTVKMLAVVVFAFVLCWLPFHVGRYLFS 244
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1894925283 256 THWE----YYAMTSfHYTIMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15131   245 KSFEagslEIALIS-QYCNLVSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
33-299 2.79e-16

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 77.40  E-value: 2.79e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGIH-EWVFGQVMCKSLLGIYT 110
Cdd:cd15061     1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADlLVGVLVLPLAIIRQLLgYWPLGSHLCDFWISLDV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVtsLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAISTV 190
Cdd:cd15061    81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMI--LAVWVISLLITSPPLVGPSWHGRRGLGSCYYTYDKGYR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLATqmTLGFFLPLLTMIVCYSVIIKTLLhaggfQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRS-THWEYYAMTSfhyt 269
Cdd:cd15061   159 IYSS--MGSFFLPLLLMLFVYLRIFRVIA-----KERKTAKTLAIVVGCFIVCWLPFFIMYLIEPfCDCQFSEALS---- 227
                         250       260       270
                  ....*....|....*....|....*....|
gi 1894925283 270 iMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15061   228 -TAFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
32-299 3.00e-16

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 77.54  E-value: 3.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKL---QSLTDVFLVNLPLADLVFVCTLPFWAYA--GIHEWVFGQVMCKSLL 106
Cdd:cd15338     1 VIMPSVFGVICFLGIIGNSIVIYTIVKKSKFrcqQTVPDIFIFNLSIVDLLFLLGMPFLIHQllGNGVWHFGETMCTLIT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 107 GIYTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTslLIWVISLLVSLPQIIYGNVFNLD--KLICGYHD 184
Cdd:cd15338    81 ALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVIC--LVWILSLLSITPVWMYAGLMPLPdgSVGCALLL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVL---ATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKI--------IFLVMAVFLLTQMPFNLMKFI 253
Cdd:cd15338   159 PNPETDTYwftLYQFFLAFALPLVVICVVYFKILQNMASTVAPLPQRSLRVrtkkvtrmAVAICLAFFICWAPFYILQLA 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1894925283 254 R-STHWEYYAmtsFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15338   239 HlSIDRPSLA---FLYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
38-296 3.30e-16

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 77.53  E-value: 3.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGI-HEWVFGQVMCKSLLGIYTINFYTS 116
Cdd:cd15153     7 YIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIqHTWPFGRFLCLLCFYLKYLNMYAS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 117 MLILTCITVDRFIVVVKATKAYNQQAKrmtWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAIS--TVVLAT 194
Cdd:cd15153    87 ICFLTCISIQRCFFLLHPFKARDWKRR---YDVGISAAVWIVVGLACLPFPLLRSKSLSNNNRSCFADLGMKklNFGAAI 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 195 QMT-----LGFFLPLLTMIVCySVIIKTLLHAGGFQ------KHRSLKIIFLVMAVFLLTQMPFN-------LMKFIRST 256
Cdd:cd15153   164 AMMtvaelFGFVIPLFIIAWC-TWKTENSLRQRNKQqqstseKQKALRMVRMCAAVFFICFAPYHinflfylMVSESIIT 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 257 HWEYYAMTSFHYTImvTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15153   243 NCEVSQVILQFHPI--SLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
32-299 3.52e-16

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 77.53  E-value: 3.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGIHE-WVFGQVMCKSLLGIY 109
Cdd:cd15056     1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADlLVAVLVMPFGAIELVNNrWIYGETFCLVRTSLD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYnqqakRMTWGKVTSLLI--WVISLLVS-LPQIIYGNVFNLDKLI-CGYHDE 185
Cdd:cd15056    81 VLLTTASIMHLCCIALDRYYAICCQPLVY-----KMTPLRVAVMLGgcWVIPTFISfLPIMQGWNHIGIEDLIaFNCASG 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLA------TQMTLGFFLPLLTMIVCYSVI----------IKTLLHAGGFQKHRSL-------------KIIFLV 236
Cdd:cd15056   156 STSCVFMVnkpfaiICSTVAFYIPALLMVLAYYRIyvaareqahqIRSLQRAGSSNHEADQhrnsrmrtetkaaKTLGII 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1894925283 237 MAVFLLTQMPF---NLMKFIRSTHWEYYAMTSFHYtimvteaIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15056   236 MGCFCVCWAPFfvtNIVDPFIGYRVPYLLWTAFLW-------LGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
32-299 3.52e-16

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 77.00  E-value: 3.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPF-WAYAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15059     1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADiLVGLLIMPFsLVNELMGYWYFGSVWCEIWLALD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATK-AYNQQAKRMtwgKVTSLLIWVISLLVSLPQIIY---GNVFNLDKLICGYHDE 185
Cdd:cd15059    81 VLFCTASIVNLCAISLDRYWSVTQAVEyNLKRTPRRA---KAMIAAVWIISAVISLPPLFGwkdEQPWHGAEPQCELSDD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 aISTVVLATqmTLGFFLPLLTMIVCYSVIiktlLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMkfirsthweyYAMTS 265
Cdd:cd15059   158 -PGYVLFSS--IGSFYIPLLIMIIVYARI----YRAAKRKERRFTLVLGVVMGAFVLCWLPFFFT----------YPLVV 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1894925283 266 FHYTIMVTEA-------IAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15059   221 VCKTCGVPELlfkfffwLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
36-298 4.81e-16

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 77.35  E-value: 4.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVCGLVGNSLVLVISIF-YHKLQSLTDVFLVNLPLADLVFVCTLP----FWAYAgiHEWVFGQVMCKSLLGIYT 110
Cdd:cd15382     5 IVYSVLFLIAAVGNLTVLLILLRnRRRKRSRVNILLMHLAIADLLVTFIMMpleiGWAAT--VAWLAGDFLCRLMLFFRA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATkaynqqaKRMTWGKVTSLLI---WVISLLVSLPQIIY-----------------G 170
Cdd:cd15382    83 FGLYLSSFVLVCISLDRYFAILKPL-------RLSDARRRGRIMLavaWVISFLCSIPQSFIfhveshpcvtwfsqcvtF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 171 NVFNLDKlicgyhDEAISTVVLATQMtlgFFLPLLTMIVCYSVII----------KTLLHAGGFQ--------------K 226
Cdd:cd15382   156 NFFPSHD------HELAYNIFNMITM---YALPLIIIVFCYSLILceisrkskekKEDVSEKSSSvrlrrssvglleraR 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 227 HRSLKIIFLVMAVFLLTQMPfnlmkfirsthweYYAMTSFHYTI---------MVTEAI---AYLRACLNPVLYAFVSLK 294
Cdd:cd15382   227 SRTLKMTIVIVLVFIICWTP-------------YFIMSLWYWFDresaskvdpRIQKGLflfAVSNSCMNPIVYGYFSID 293

                  ....
gi 1894925283 295 FRKN 298
Cdd:cd15382   294 LRRE 297
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
34-299 6.22e-16

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 76.63  E-value: 6.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA---YAGIHeWVFGQVMCKSLLGIYT 110
Cdd:cd15201     3 LPPVLILEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFRTdyyLRGKH-WKFGDIPCRIVLFMLA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSLLIWVISLLVSL----PQIIYGNVFNLDKL-ICGYHDE 185
Cdd:cd15201    82 MNRAGSIFFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLTIAMTVYLltkkHLFPRGNATQCESFnICTGTDS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 aiSTVVLATQMTLGFFLPLLTMIVCySVIIKTLLHAGGFQKH----RSLKIIFLVMAVFLLTQMPFNLMK--FIRSTHW- 258
Cdd:cd15201   162 --SSNWHEAMFLLEFFLPLAIILYC-SVRIIWQLRGRQLDRHakikRAVQFIMVVAIVFIICFLPSNVTRiaIWILKHTs 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1894925283 259 --EYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15201   239 neDCQYYRSVDLAFYITISFTYFNSMLDPVVYYFSSPSFKNFY 281
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
37-299 6.40e-16

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 76.49  E-value: 6.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVC-GLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCT-LPFWAYAGIHE-WVFGQVMCKSLLGIYTINF 113
Cdd:cd15327     5 VFLAIFILmAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTvLPFSATLEVLGfWAFGRVFCDIWAAVDVLCC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSL-PQIIYGNVFNLDKLICGYHDEAISTVVL 192
Cdd:cd15327    85 TASILSLCVISVDRYVGVKHSLKYPTIMTERK--AGVILVLLWVSSMVISIgPLLGWKEPPPPDESICSITEEPGYALFS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 193 AtqmTLGFFLPLLTMIVCYsviIKTLLHAGGFQKH-RSLKIIFLVMAVFLLTQMPFNLMKFIRSThweYYAMTSFHYTIM 271
Cdd:cd15327   163 S---LFSFYLPLMVILVMY---FRVYVVALKFSREkKAAKTLAIVVGVFILCWFPFFFVLPLGSF---FPALKPSEMVFK 233
                         250       260
                  ....*....|....*....|....*...
gi 1894925283 272 VTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15327   234 VIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
36-299 7.55e-16

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 76.26  E-value: 7.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVcGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGI-HEWVFGQVMCkSLLGIYTINF 113
Cdd:cd15066     5 AMTLIILA-AIFGNLLVIISVMRHRKLRVITNYFVVSLAMADmLVALCAMTFNASVEItGRWMFGYFMC-DVWNSLDVYF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YT-SMLILTCITVDRFIVVVKATKAYNqqakRMTWGKVTSLL--IWVISLLVSLPQI---IYGNVFNLDKLIcgYHDEAI 187
Cdd:cd15066    83 STaSILHLCCISVDRYYAIVQPLEYPS----KMTKRRVAIMLanVWISPALISFLPIflgWYTTEEHLQYRK--THPDQC 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 STVVLATQM----TLGFFLPLLTMIVCYSVIIKTLLhaggfQKHRSLKIIFLVMAVFLLTQMPFNLmkfirsthweYYAM 263
Cdd:cd15066   157 EFVVNKIYAlissSVSFWIPCIVMIFTYYRIYLEAK-----REHKAAKTLGIIMGAFILCWLPFFL----------WYVT 221
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1894925283 264 TSF-----HYTIMVTEA---IAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15066   222 TTLcgdacPYPPILVSIlfwIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
38-299 1.01e-15

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 76.41  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWA-YAGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15396     7 YSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDvLVCVMCIPFTAvYTLMDHWIFGETMCKLTSFVQSVSVSV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKAtKAYNQQAKRMTWGKVtslLIWVISLLVSLPQIIYGNV-------------FNLDKLICGY 182
Cdd:cd15396    87 SIFSLVLIAIERYQLIVNP-RGWKPSASHAYWGIV---LIWLFSLMISIPFLIFHQLtdepfrnlsshsdFYKDKVVCIE 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 183 H--DEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGF-------------QKHRSLKIIFLVMAvFLLTQMPF 247
Cdd:cd15396   163 AwpSETERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNSKidrmrenesrlseNKRINTMLISIVVT-FAACWLPL 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1894925283 248 NLMKFIRSthWEYYAMTSFHYTIMVT--EAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15396   242 NIFNVVFD--WNHEVLMSCHHNLVFTlcHLVAMVSTCINPIFYGFLNKNFQKDL 293
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
33-216 1.01e-15

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 76.46  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE-WVFGQVMCK--SLLGIY 109
Cdd:cd15079     2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEgWALGPLGCQiyAFLGSL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TinFYTSMLILTCITVDRFIVVVKATkaynqQAKRMTWGKVTS--LLIWVISLLVSLPQIIYG-NVFNLDKLI--CG--Y 182
Cdd:cd15079    82 S--GIGSIWTNAAIAYDRYNVIVKPL-----NGNPLTRGKALLliLFIWLYALPWALLPLLFGwGRYVPEGFLtsCSfdY 154
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1894925283 183 HDEAISTVV-LATQMTLGFFLPLLTMIVCYSVIIK 216
Cdd:cd15079   155 LTRDWNTRSfVATIFVFAYVIPLIIIIYCYSFIVK 189
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
32-297 1.14e-15

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 75.98  E-value: 1.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTdVFLVNLPLADLVFVCTLPFWAY--AGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15969     1 IVFPVLYLIIFIGSILLNGLAVWIFFHIRNKTSFI-FYLKNIVIADLLMTLTFPFKIIqdSGLGPWNFNFFLCRYTSVLF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKayNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLI--CGYHDEAI 187
Cdd:cd15969    80 YASMYTSIVFLGLISLDRYLKVVKPFG--DSRMYSITFTKVLSACVWLIMAFLSLPNIILTNGQPTEDNIhdCSKLKSPL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 S----TVVLATQMTLgFFLPLLTMIVCYSVIIKTLLHAG------GFQKHRSLKIIFLVMAVFLLTQMPFNLMK--FIRS 255
Cdd:cd15969   158 GvkwhTAVSYINICI-FVAVLVILIVCYISISRYIYKSSkqfissSSRTRKHNQSIRVVVAVFFVCFLPYHLCRipFTFS 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1894925283 256 THWEYYAMTSFHYTIMVTEAIAYLRA---CLNPVLYAFVSLKFRK 297
Cdd:cd15969   237 QLDKILDCTIKTILYYCKEATLFLSAcnvCLDPIIYFFMCRSFSQ 281
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
40-296 1.22e-15

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 76.26  E-value: 1.22e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLvISIFYHKLQSLT-DVFLVNLPLADLV--FVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTS 116
Cdd:cd14986     9 VLFVFTLVGNGLVI-LVLRRKRKKRSRvNIFILNLAIADLVvaFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 117 MLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSllIWVISLLVSLPQIIygnVFNLDKLICGYHD-------EAIST 189
Cdd:cd14986    88 TYILVSMSLDRYQAIVKPMSS--LKPRKRARLMIVV--AWVLSFLFSIPQLV---IFVERELGDGVHQcwssfytPWQRK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTLGFFLPLLTMIVCYSVIIKTL-LHAGGFQ---------------------------KHRSLKIIFLVMAVFL 241
Cdd:cd14986   161 VYITWLATYVFVIPLIILSYCYGRILRTIwIRSRQKTdrpiaptamscrsvscvssrvslisraKIKTIKMTLVIILAFI 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1894925283 242 LTQMPFnlmkFIRSTHWEYYAMTSF-HYTIMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd14986   241 LCWTPY----FIVQLLDVYAGMQQLeNDAYVVSETLASLNSALNPLIYGFFSSHLS 292
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
34-299 1.32e-15

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 75.44  E-value: 1.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLV-GNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPFWA-YAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15064     2 LISVLLSLIILATIlGNALVIAAILLTRKLHTPANYLIASLAVADLlVAVLVMPLSAvYELTGRWILGQVLCDIWISLDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATK-AYNQQAKRMTwgkVTSLLIWVISLLVSLPQIIYGNVFN-LDKLICGYHDEAIS 188
Cdd:cd15064    82 TCCTASILHLCVIALDRYWAITDAVEyAHKRTPKRAA---VMIALVWTLSICISLPPLFGWRTPDsEDPSECLISQDIGY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVlatqMTLG-FFLPLLTMIVCYSVIIKTllhagGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIR---STHWEYYAMT 264
Cdd:cd15064   159 TIF----STFGaFYIPLLLMLILYWKIYRA-----AARERKAAKTLGIILGAFIVCWLPFFLVALIVplcSHCWIPLALK 229
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1894925283 265 SFhytimvTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15064   230 SF------FLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
35-299 2.24e-15

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 75.14  E-value: 2.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  35 PCMYLVVFVCGLVGNslVLVISIFYHKLQ----SLTDVFLVNLPLAD-LVFVCTLPFWAYA-GIHEWVFGQVMCKSLLGI 108
Cdd:cd15002     3 PILLGVICLLGFAGN--LMVIGILLNNARkgkpSLIDSLILNLSAADlLLLLFSVPFRAAAySKGSWPLGWFVCKTADWF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgkVTSLLIWVISLLVSLPQIIYG------NVFNLDKLICGY 182
Cdd:cd15002    81 GHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRIT---AVVASIWVPACLLPLPQWLFRtvkqseGVYLCILCIPPL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 183 HDEAISTVVLATQMtLGFFLPLLTMIVCYSVIIKTLLHAGGFQKH-----RSLKI---IFLVMAVFLLTQMP-FNLMKFI 253
Cdd:cd15002   158 AHEFMSAFVKLYPL-FVFCLPLTFALFYFWRAYGQCQRRGTKTQNlrnqiRSRKLthmLLSVVLAFTILWLPeWVAWLWL 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1894925283 254 RstHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15002   237 I--HIKSSGSSPPQLFNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
33-299 4.05e-15

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 74.36  E-value: 4.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFW-AYAGI-HEWVFGQVMCKSLLGIYT 110
Cdd:cd15922     2 AIPVFLSLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAAPLLiAYFSLgSHWPFGQFLCQLKVFLLS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKayNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLD-KLIC-GYHDEAIS 188
Cdd:cd15922    82 THMYGSIYFLMLISIHRYVTVVHYNW--KSLWKKKSFMKKLCLGVWLLLFVQGLPFFFVLKTSVIDgKTKClSIHQSELS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLATQM---TLGFFLPLLTMIVCYSVIIKTLLHA------GGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWE 259
Cdd:cd15922   160 LLYFVWNFvllILGFLLPFGVSLTCYALLGASIAKMnsnnarGRAMKAKSLQMIGISLVIFIICFVPLHVTRTVGVVVKL 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1894925283 260 YYAM--TSFHYTIM---VTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15922   240 FYPEscTLLHKVEVayyISWVLTGVNCCLDPLLYCFASEKFRKSF 284
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
38-299 5.78e-15

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 73.82  E-value: 5.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVcgLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPF-WAYAGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15323     9 FLIVFT--IVGNVLVVIAVLTSRALRAPQNLFLVSLASADiLVATLVMPFsLANELMGYWYFGQVWCNIYLALDVLFCTS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQII--YGNVFNLDKLICGYHDEaisTVVLA 193
Cdd:cd15323    87 SIVHLCAISLDRYWSVTQAVEYNLKRTPRRV--KAIIVTVWLISAVISFPPLIsmYRDPEGDVYPQCKLNDE---TWYIL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 194 TQMTLGFFLPLLTMIVCYSVIIKTllhaGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYTIMVT 273
Cdd:cd15323   162 SSCIGSFFAPCLIMILVYIRIYRV----AKAREKRFTFVLAVVMGVFVVCWFPFFFSYSLYGICREACEVPEPLFKFFFW 237
                         250       260
                  ....*....|....*....|....*.
gi 1894925283 274 eaIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15323   238 --IGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
41-299 2.24e-14

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 71.93  E-value: 2.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  41 VFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPFWA-YAGIHEWVFGQVMCKSLLGIYTINFYTSML 118
Cdd:cd15330    10 LILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLmVSVLVLPMAAlYQVLNKWTLGQVTCDLFIALDVLCCTSSIL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 119 ILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGNVFN--LDKLICGYHDEAISTVVlatqM 196
Cdd:cd15330    90 HLCAIALDRYWAITDPIDYVNKRTPRR--AAVLISLTWLIGFSISIPPMLGWRTPEdrSDPDACTISKDPGYTIY----S 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 197 TLG-FFLPLLTMIVCYSVIIKtllhaGGFQKHRSLKIIFLVMAVFLLTQMPFnlmkFIRSTHWEYYAMTSF--HYTIMVT 273
Cdd:cd15330   164 TFGaFYIPLILMLVLYGRIFK-----AAARERKTVKTLGIIMGTFILCWLPF----FIVALVLPFCESTCHmpELLGAII 234
                         250       260
                  ....*....|....*....|....*.
gi 1894925283 274 EAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15330   235 NWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
45-299 2.27e-14

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 72.14  E-value: 2.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  45 GLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCT-LPFWA-YAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTC 122
Cdd:cd15062    14 AIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTvLPFSAtLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCV 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 123 ITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSL-PQIIYGNVFNLDKLICGYHDEAISTVVlatqMTLG-F 200
Cdd:cd15062    94 ISVDRYIGVRYPLNYPTIVTARR--ATVALLIVWVLSLVISIgPLLGWKEPAPADEQACGVNEEPGYVLF----SSLGsF 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 201 FLPLLTMIVCYSVIIKTLLHAGgfQKHRSLKIIFLVMAVFLLTQMPFNLMkfirsthweyYAMTSFHYTIMVTEAI---- 276
Cdd:cd15062   168 YLPLAIILVMYCRVYVVAFKFS--REKKAAKTLGIVVGAFVLCWFPFFVV----------LPLGSLFSTLKPPEPVfkvv 235
                         250       260
                  ....*....|....*....|....*.
gi 1894925283 277 ---AYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15062   236 fwlGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
37-299 2.38e-14

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 72.48  E-value: 2.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCgLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWA-YAGIHEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15058     7 LALIILAI-VVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMgLLVVPLGAtIVVTGKWQLGNFWCELWTSVDVLCVT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVvkaTKAYNQQAKRMTW-GKVTSLLIWVISLLVSLPQIIYGN--VFNLDKLICgYHDEAisTVV 191
Cdd:cd15058    86 ASIETLCVIAVDRYIAI---TRPLRYQVLLTKRrARVIVCVVWIVSALVSFVPIMNQWwrANDPEANDC-YQDPT--CCD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 LATQMT-------LGFFLPLLTMIVCYSVII--------------------------------------KTLLHagGFQK 226
Cdd:cd15058   160 FRTNMAyaiassvVSFYIPLLIMIFVYARVFliatrqlqlidkrrlrfqsecpapqttspegkrssgrrPSRLT--VVKE 237
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1894925283 227 HRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYtimvTEAIAYLRACLNPVLYAFvSLKFRKNF 299
Cdd:cd15058   238 HKALKTLGIIMGTFTLCWLPFFIANIINVFNRNLPPGEVFLL----LNWLGYINSGLNPIIYCR-SPEFRTAF 305
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
32-299 3.31e-14

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 71.72  E-value: 3.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA-YAGIHE-WVFGQVMCKSLLGIY 109
Cdd:cd15200     1 AFLAPVLGIEFVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIdYYLRNEvWRFGATACQVNLFML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRmTWGKVtSLLIWVISLLVSLPqiIYGNVFNLDKLIC-GY-HDEAI 187
Cdd:cd15200    81 SMNRTASIVFLTAIALNRYLKVVHPHHQLSKASVG-CAAKV-AAGLWILILLLNIH--LLLLDHVQSNSTClSYdHGTDP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 STVVLATQMT--LGFFLPLLTMIVCYSVIIKTLLH---AGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYA 262
Cdd:cd15200   157 SASDRWHRILffLEFFLPLGIILFCIFSIILTLKQrklAKQAGPQRAVKVLAVIVLVYTVCFLPSILFALASLVAFKVSQ 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 263 MTSFHYTIMV---TEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15200   237 CRSLDLCTQLfhgSLAFTYLNSALDPVLYCFSSPSFLNQS 276
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
38-299 3.66e-14

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 72.11  E-value: 3.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGIHEW--VFGQVMCKSLLGIYTINFY 114
Cdd:cd15358     7 YLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDlLVLLLGMPLELYEMWSNYpfLLGAGGCYFKTLLFETVCF 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKA----YNQQAKRMTwgkvtsLLIWVISLLVSLPQIIYGNVFNLDKLICG-YHDEAIST 189
Cdd:cd15358    87 ASILNVTALSVERYIAVVHPLKAkyvvTRTHAKRVI------GAVWVVSILCSIPNTSLHGIFQLTVPCRGpVPDSATCM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VV-------LATQMT--LGFFLPLLTMIVCYSVI--------------IKTLLHAGGFQKHRS----------LKIIFLV 236
Cdd:cd15358   161 LVkprwmynLIIQITtlLFFFLPMGTISVLYLLIglqlkrekmllvleAKGSKAGDSYQHRRIqqekrrrrqvTKMLFVL 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1894925283 237 MAVFLLTQMPFNLMKFIRS--THWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15358   241 VVVFGICWAPFHTDRLMWSfiSQWTGELHLAFQYVHIISGVFFYLSSAANPVLYNLMSTRFREMF 305
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
40-297 6.53e-14

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 71.20  E-value: 6.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF--VCTLPFWAYAGIHE-WVFGQVMCKSLLGIYTINFYTS 116
Cdd:cd15337     9 IVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFsaVNGFPLKTISSFNKkWIWGKVACELYGFAGGIFGFMS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 117 MLILTCITVDRFIVVVKATKAynqqAKRMTWGKVTS--LLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAIST----- 189
Cdd:cd15337    89 ITTLAAISIDRYLVIAKPLEA----MKKMTFKRAFImiIIIWLWSLLWSIPPFFGWGRYVPEGFQTSCTFDYLSRdlnnr 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTLGFFLPLLTMIVCYSVIIKTL-LHAGGFQKH--------------------RSLKIIFLVMAVFLLTQMPF- 247
Cdd:cd15337   165 LFILGLFIFGFLCPLLIIIFCYVNIIRAVrNHEKEMTQTaksgmgkdtekndarkkaeiRIAKVAIILISLFLLSWTPYa 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1894925283 248 --NLMKFIRSTHWeyyaMTSFHYTIMVTEAIAylRACLNPVLYAFVSLKFRK 297
Cdd:cd15337   245 vvALLGQFGPAYW----ITPYVSELPVMFAKA--SAIYNPIIYALSHPKFRA 290
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
36-299 6.70e-14

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 70.82  E-value: 6.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVCGLV-GNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWA-YAGIHEWVFGQVMCksllgiytiN 112
Cdd:cd15051     4 GVVLAVIILLTViGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDlLLGLLVLPFSAiYELRGEWPLGPVFC---------N 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTC---------ITVDRFIVVvkaTKAYnQQAKRMTWGKVTSLL--IWVISLLVSLPQIIYG------NVFNL 175
Cdd:cd15051    75 IYISLDVMLCtasilnlfaISLDRYLAI---TAPL-RYPSRVTPRRVAIALaaIWVVSLAVSFLPIHLGwntpdgRVQNG 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 176 D-KLICGYHDEAISTVVLAtqmTLGFFLPLLTMIVCYSVIIKTL---------LHAGGFQK----------HRSLKIIFL 235
Cdd:cd15051   151 DtPNQCRFELNPPYVLLVA---IGTFYLPLLIMCGVYLRIFRIAreqakrinaLTPASTANssksaatareHKATVTLAA 227
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1894925283 236 VMAVFLLTQMPFnlmkfirSTHWEYYAMTSFHYTIMVTEAI---AYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15051   228 VLGAFIICWFPY-------FTYFTYRGLCGDNINETALSVVlwlGYANSALNPILYAFLNRDFRRAF 287
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
38-296 8.11e-14

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 70.62  E-value: 8.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPF-WAYAGIHEWVFGQVMCkSLLGIYTInFYTS 116
Cdd:cd15166     7 YSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFrMVYYAKDEWPFGDYFC-RILGALTV-FYPS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 117 MLI--LTCITVDRFIVVVKATkaYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIY-------GNVFNLDKLICGYHDEAI 187
Cdd:cd15166    85 IALwlLAFISADRYMAIVQPK--HAKELKNTPKAVLACVGVWIMTLASTFPLLFLyedpdkaSNFTTCLKMLDIIHLKEV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 StVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQ-----KHRSLKIIFLVMAVFLLTQMPFNL---MKFIRSTHWE 259
Cdd:cd15166   163 N-VLNFTRLIFFFLIPLFIMIGCYLVIIHNLVHGRTSKlkpkvKEKSIRIIITLIVQVLVCFVPFHIcfaFLMLQNGDNS 241
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1894925283 260 YYAMTSFHYTIMvteaiaYLRACLNPVLYAFVSLKFR 296
Cdd:cd15166   242 YNPWAAFTTFLM------NLSTCLDVILYYIVSKQFQ 272
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
38-297 1.20e-13

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 70.14  E-value: 1.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHE-WVFGQVMCKSLLGIYTINFYTS 116
Cdd:cd15152     7 YTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKsWPFGKFLCMFCFYLKYVNMYAS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 117 MLILTCITVDRFIVVVKATKAYNQQAKrmtWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYH------DEAISTV 190
Cdd:cd15152    87 IYFLVCISVRRCLYLIYPFRYNDCKRK---CDVYISIAGWLVVCVGCLPFPLLRQSQDTNPTCCFADlplrnvGLTTSVI 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLATQMTLGFFLPLLTMIVCYSVIIKTL------LHAGGfQKHRSLKIIFLVMAVFLLTQMPFNLM---------KFIRS 255
Cdd:cd15152   164 MLTIAELTGFVTPLLIVLYCSWKTVMSLrektpvLQDLG-EKKKALKMILTCAVVFLICFAPYHISfpldflvksNKIKS 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1894925283 256 THWEyYAMTSFHytiMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15152   243 CTAR-KVILIFH---PVALCLASLNSCLDPVIYYFTTDEFKR 280
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
38-299 2.00e-13

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 69.57  E-value: 2.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVcgLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPF-WAYAGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15321    15 FLILFT--IFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADiLVATLIIPFsLANELMGYWYFRKTWCEIYLALDVLFCTS 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNVFNLD---KLICGYHDEAisTVVL 192
Cdd:cd15321    93 SIVHLCAISLDRYWSVSRAIEYNSKRTPRRI--KCIILIVWLIAAVISLPPLIYKGKQKDEqggLPQCKLNEEA--WYIL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 193 ATQMTlGFFLPLLTMIVCYsviIKTLLHAGGFQKhRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYTIMV 272
Cdd:cd15321   169 SSSIG-SFFAPCLIMILVY---LRIYLIAKNREK-RFTFVLAVVIGVFVLCWFPFFFSYSLGAICPELCKVPHSLFQFFF 243
                         250       260
                  ....*....|....*....|....*..
gi 1894925283 273 TeaIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15321   244 W--IGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
40-292 2.55e-13

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 68.80  E-value: 2.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVIsiFYHKLQSLTDV--FLVNLPLADLV--FVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15196     9 TILVLALFGNSCVLLV--LYRRRRKLSRMhlFILHLSVADLLvaLFNVLPQLIWDITYRFYGGDLLCRLVKYLQVVGMYA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMtwgKVTSLLIWVISLLVSLPQIIygnVFNLDKLICGYHD---------EA 186
Cdd:cd15196    87 SSYVLVATAIDRYIAICHPLSSHRWTSRRV---HLMVAIAWVLSLLLSIPQLF---IFSYQEVGSGVYDcwatfeppwGL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATqmTLGFFLPLLTMIVCYSVIIKTLLHAggfqKHRSLKIIFLVMAVFLLTQMPFnlmkFIRSTHWEYYAMTSF 266
Cdd:cd15196   161 RAYITWFT--VAVFVVPLIILAFCYGRICYVVWRA----KIKTVKLTLVVVACYIVCWTPF----FVVQMWAAWDPTAPI 230
                         250       260
                  ....*....|....*....|....*..
gi 1894925283 267 HYTIMVTEAI-AYLRACLNPVLYAFVS 292
Cdd:cd15196   231 EGPAFVIIMLlASLNSCTNPWIYLAFS 257
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
32-297 2.73e-13

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 69.38  E-value: 2.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLvFVCT--LPFW-AYAGIHEWVFGQVMCKSLLGI 108
Cdd:cd15397     1 VFLVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDI-LVCLvcLPFTvVYTLMDYWIFGEVLCKMTPFI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINFYTSMLILTCITVDRFIVVVKAT--KAYNQQAkrmtwgKVTSLLIWVISLLVSLP-------------QIIYGNVF 173
Cdd:cd15397    80 QCMSVTVSILSLVLIALERHQLIINPTgwKPSVSQA------YLAVVVIWMLACFISLPflafhiltdepykNLSHFFAP 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 174 NLDKLIC------GYHDEAISTVVLATQmtlgFFLPLLTMIVCYSVII------KTLLHAGG-----FQKHRSLKIIFLV 236
Cdd:cd15397   154 LADKAVCteswpsEHHKLAYTTWLLLFQ----YCLPLLFILVCYLRIYlrlrrrKDMLERRGeynrrAGHSKRINVMLVS 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1894925283 237 M-AVFLLTQMPFNLMKFIrsTHWEYYAMTSFHYTIM--VTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15397   230 LvAAFALCWLPLNVFNAI--ADWNHEAIPHCQHNLIfsLCHLAAMASTCVNPIIYGFLNSNFKK 291
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
38-299 3.07e-13

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 69.12  E-value: 3.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVC--TLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd16002     7 YSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAfnTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATkaynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLD-KLIC-----GYHDEAIST 189
Cdd:cd16002    87 SIYSMTAIALDRYMAIIHPL----QPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMPgRVVCyvewpEHEERKYET 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTLGFFLPLLTMIVCYSVIIKTL------------LHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTH 257
Cdd:cd16002   163 VYHVCVTVLIYFLPLLVIGCAYTVVGITLwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPYHIYFLLQYFH 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1894925283 258 WEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd16002   243 PELYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
38-299 3.72e-13

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 68.69  E-value: 3.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPF-WAYAGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15399     7 YCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLmVNTLCLPFtLVYTLLDEWKFGAVLCHLVPYAQALAVHV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVkatkaYNQQAKrmtWGKVTSLLI----WVISLLVSLPQIIYGNvFNLDKLICGYHDEAIS--- 188
Cdd:cd15399    87 STVTLTVIALDRHRCIV-----YHLESK---ISKKISFLIigltWAASALLASPLAIFRE-YSVIEISPDFKIQACSekw 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 --------TVVLATQMTLGFFLPLltMIVCYSVI-----IKTLLHAGGFQKH------RSLKIIFLVMAVFLLTQMPFNL 249
Cdd:cd15399   158 pngtlndgTIYSVSMLLIQYVLPL--AIISYAYIriwtkLKNHVSPGGGNDHyhqrrrKTTKMLVCVVVVFAVSWLPFHA 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1894925283 250 MKFIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15399   236 FQLASDIDSKVLDLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
38-299 4.31e-13

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 68.57  E-value: 4.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-----VCTLPFWaYAGIHEWVFGQVMCKSLLGIYTIN 112
Cdd:cd14995     7 VLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVlvaagLPNEIES-LLGPDSWIYGYAGCLLITYLQYLG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISL--------LVSLPQIIYGNVfnlDKLICGYH- 183
Cdd:cd14995    86 INASSLSITAFTIERYIAICHPMKA--QFICTVSRAKKIICFVWIFTSlycspwlfLLDLSIKHYGDD---IVVRCGYKv 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 184 DEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLlhaggFQKHRSL-KIIFLVMAVFLLTQMPFNLMKFIRSthweyYA 262
Cdd:cd14995   161 SRHYYLPIYLADFVLFYVIPLLLAIVLYGLIGRIL-----FSSRKQVtKMLAVVVVLFALLWMPYRTLVVYNS-----FA 230
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1894925283 263 MTSFH--YTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14995   231 SPPYLdlWFLLFCRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
38-299 4.35e-13

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 68.71  E-value: 4.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGIHEW--VFGQVMCKSLLGIYTINFY 114
Cdd:cd15133     7 YLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDlLVLLLGMPLELYELWQNYpfLLGSGGCYFKTFLFETVCL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTslLIWVISLLVSLPQIIYGNVFNL-----DKLICGY-HDEAIS 188
Cdd:cd15133    87 ASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLG--CVWGVSMLCALPNTSLHGIKFLgsgvpASAQCTVrKPQAIY 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLATQMTLGFFLPLLTMIVCYSVI-----IKTLLHAGGFQKHRSL----------------KIIFLVMAVFLLTQMPF 247
Cdd:cd15133   165 NMIPQHTGHLFFVLPMAVISVLYLLMalrlaRERGLDATGAGSKIGTrtgqllqhprtraqvtKMLFILVVVFAICWAPF 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1894925283 248 NLMKFIRS--THWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15133   245 HIDRLMWSfiSDWTDNLHEVFQYVHIISGVFFYLSSAVNPILYNLMSTRFREMF 298
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
39-304 4.56e-13

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 68.32  E-value: 4.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL---VFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15306     8 LMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLlvgLFVMPIALLTILFEAMWPLPLVLCPIWLFLDVLFSTA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKA--YNQQAKRMTwgKVTslLIWVISLLVSLPQIIYG---NVFNLDKLICGYHDEAISTV 190
Cdd:cd15306    88 SIMHLCAISLDRYIAIKKPIQAsqYNSRATAFI--KIT--VVWLISIGIAIPVPIKGietDVDNPNNITCVLTKERFGDF 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLATQMTlGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKfIRSTHWEYYAMTSFHYTI 270
Cdd:cd15306   164 ILFGSLA-AFFTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFITN-ITSVLCDSCNQTTLQMLM 241
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1894925283 271 MVTEAIAYLRACLNPVLYAFVSLKFRKNFWKLVK 304
Cdd:cd15306   242 EIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYIT 275
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
39-299 5.48e-13

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 67.94  E-value: 5.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGIH--EWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15308     8 VLLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLaLLVLPLYVYSEFQggVWTLSPVLCDALMTMDVMLCTA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSllIWVISLLVSLPqIIYG--NVFNLDKLICGYHDEaiSTVVLA 193
Cdd:cd15308    88 SIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISA--TWILSFAVASP-VIFGlnNVPNRDPAVCKLEDN--NYVVYS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 194 TqmTLGFFLPLLTMIVCYSVIIKTLlhaggFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFhytIMVT 273
Cdd:cd15308   163 S--VCSFFIPCPVMLVLYCAMFRGL-----GRERKAMRVLPVVVGAFLFCWTPFFVVHITRALCESCSIPPQL---ISIV 232
                         250       260
                  ....*....|....*....|....*.
gi 1894925283 274 EAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15308   233 TWLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
32-298 5.88e-13

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 68.30  E-value: 5.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVIsIFYHKLQSLTDVFLVNLPLADLVFVCTLPF--WAYAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15150     1 VIFPLLYTVLFIVGLTMNGLAMRV-FFQIPSKSNFIIFLKNTVISDLLMILTFPFkiLSDAKLGSWPLRGFVCQVTSVIF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNqqAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLI--CGYHDEAI 187
Cdd:cd15150    80 YFTMYISILFLGLITIDRYQKTTRPFKTSN--PKNLLGAKILSTVIWASMFALSLPNMILTNRQPTPKNVkkCSLLKSEF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 STV---VLATQMTLGFFLPLLTMIVCYSVIIKTLLHA------GGFQKHRSLKI-IFLVMAVFLLTQMPFNLMKF---IR 254
Cdd:cd15150   158 GLVwheIVNYICQVIFWVNFLIVIVCYTLITKELYKSykrtrgVGKVSRKKVNVkVFIIIAVFFICFVPFHFARIpytLS 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1894925283 255 STH--WEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKN 298
Cdd:cd15150   238 QTRdvFDCTAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNS 283
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
37-299 6.61e-13

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 67.97  E-value: 6.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGI-HEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15978     6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLcLFCMPFTLIPNLlKDFIFGSAVCKTATYFMGISVS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSllIWVISLLVSLPQIIYGNVFNLDKL------ICG--YHDEA 186
Cdd:cd15978    86 VSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAA--TWCLSFTIMLPYPIYSNLVPFTRInnstgnMCRllWPNDV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGF--QKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMT 264
Cdd:cd15978   164 TQQSWYIFLLLILFLIPGIVMMTAYGLISLELYRGIKFlmAKKRVIRMLIVIVILFFLCWTPIFSANAWRAFDTRSADRL 243
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1894925283 265 SFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15978   244 LSGAPISFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
52-296 7.06e-13

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 67.93  E-value: 7.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  52 VLVISIFYHKLQSLTD--VFLVNLPLADLVF-VCTLPF-WAYAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTCITVDR 127
Cdd:cd15391    19 YSVIVVFYDGRRSRTDlnYYLINLAVSDLIMaLFCMPFtFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAIGIDR 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 128 FIVVVKATKAYNQQAKrmtwGKVTSLLIWVISLLVSLPQIIYGNV-----FNLDKLICG------YHDEAISTVVLatqM 196
Cdd:cd15391    99 FFAVIFPLRSRHTKSR----TKCIIASIWAISFSLSSVQLFAGRTqrygqYSEGRVLCGeswpgpDTSRSAYTVFV---M 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 197 TLGFFLPLLTMIVCYSVIIKTL---------LHAGGFQKHRS----LKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAM 263
Cdd:cd15391   172 LLTYIIPLLILTSTYGYVGFRLwnrtapgnaDKGRDDMQIKSkrkvIKMLVFVVLMFGICWLPLHLFNLVQDFSTVFRNM 251
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1894925283 264 TSfHYTIMVTEA---IAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15391   252 PQ-HTTRLIYGAchwIAMSNSFVNPIIYLFMNDSFR 286
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
37-299 8.21e-13

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 67.30  E-value: 8.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPFWAYAGI--HEWVFGQVMCKSLLGIYTINF 113
Cdd:cd15310     6 SYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLlVATLVMPWVVYLEVtgGVWNFSRICCDVFVTLDVMMC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKaYNQQAKRMTWGKVTSLL--IWVISLLVSLPqIIYGNVFNLDKLICgyhdeAISTVV 191
Cdd:cd15310    86 TASILNLCAISIDRYTAVVMPVH-YQHGTGQSSCRRVSLMItaVWVLAFAVSCP-LLFGFNTTGDPTVC-----SISNPD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 LATQMTL-GFFLPLLTMIVCYSVIIKTLLhaggfQKHRSLKIIFLVMAVFLLTQMPFNLMKfIRSTHWEYYAMTSFHYTi 270
Cdd:cd15310   159 FVIYSSVvSFYLPFGVTLLVYVRIYVVLL-----REKKATQMLAIVLGAFIVCWLPFFLTH-ILNTHCQACHVPPELYS- 231
                         250       260
                  ....*....|....*....|....*....
gi 1894925283 271 mVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15310   232 -ATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
38-299 8.25e-13

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 67.52  E-value: 8.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVcgLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPFWAYAGIHE-WVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15063     9 FLNVLV--VLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLlVGTLVLPFSAVNEVLDvWIFGHTWCQIWLAVDVWMCTA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAISTVVLATQ 195
Cdd:cd15063    87 SILNLCAISLDRYLAITRPIRYPSLMSTKR--AKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSLPCTCELTNG 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 196 ------MTLG-FFLPLLTMIVCYSVIIKTllhagGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHy 268
Cdd:cd15063   165 rgyviySALGsFYIPMLVMLFFYFRIYRA-----ARMETKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCEDCIPPLLFS- 238
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1894925283 269 timVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15063   239 ---VFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
40-299 1.59e-12

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 66.43  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPF-WAYAGIHEWVFGQVMCKSLLGIYTINFYTSM 117
Cdd:cd15324     9 VIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADiLVATLVIPFsLANEVMGYWYFGSTWCAFYLALDVLFCTSSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 118 LILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTslLIWVISLLVSLPQIIygnVFNLDKLICGYHDEaisTVVLATQMT 197
Cdd:cd15324    89 VHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIA--VVWVISAVISFPPLL---MTKHDEWECLLNDE---TWYILSSCT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 198 LGFFLPLLTMIVCYSVIIKTllhaGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYTIMVTeaIA 277
Cdd:cd15324   161 VSFFAPGLIMILVYCKIYRV----AKMREKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVCRKRCGIPDALFNLFFW--IG 234
                         250       260
                  ....*....|....*....|..
gi 1894925283 278 YLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15324   235 YCNSSVNPIIYTIFNRDFRKAF 256
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
34-299 2.47e-12

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 66.46  E-value: 2.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCT-LPFWAYAGI-HEWVFGQVMCKSLLGIYTI 111
Cdd:cd15124     3 IPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTcAPVDASRYLaDEWLFGRVGCKLIPFIQLT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVF-------NLDKLICG--- 181
Cdd:cd15124    83 SVGVSVFTLTALSADRYKAIVRPMDI--QASNALMKICLKAALIWILSMLLAIPEAVFSDLHpfydkstNKTFVSCApyp 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 182 YHDEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGF--------------QKHRSLKIIFLVMAVFLLTQMPF 247
Cdd:cd15124   161 HSNELHPKIHSMASFLIFYVIPLSIISVYYYFIAKNLIRSAYNlpvegnvhvrrqieSRKRLAKTVLVFVGLFAFCWLPN 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1894925283 248 NLMKFIRSTHWEYYAMTSFHY-TIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15124   241 HIIYLYRSYHYSEVDTSMLHFvSSICARILAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
46-299 2.50e-12

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 66.07  E-value: 2.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  46 LVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCT-LPFWAYAGI-HEWVFGQVMCKSLLGIYTINFYTSMLILTCI 123
Cdd:cd15326    15 IVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTvLPFSATLEIlGYWVFGRIFCDIWAAVDVLCCTASILSLCAI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 124 TVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSL-PQIIYGNVFNLDKLICGYHDEaistVVLATQMTLG-FF 201
Cdd:cd15326    95 SIDRYIGVRHSLQYPTIVTRKRAI--LALLGVWVLSTVISIgPLLGWKEPAPPDDKVCEITEE----PFYALFSSLGsFY 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 202 LPLLTMIVCYSVIIKTLLHAGgfQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSThweYYAMTSFHYTIMVTEAIAYLRA 281
Cdd:cd15326   169 IPLIVILVMYCRVYIVALKFS--REKKAAKTLGIVVGMFILCWLPFFIALPLGSL---FSHLKPPETLFKIIFWLGYFNS 243
                         250
                  ....*....|....*...
gi 1894925283 282 CLNPVLYAFVSLKFRKNF 299
Cdd:cd15326   244 CLNPIIYPCSSKEFKRAF 261
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
42-299 2.59e-12

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 66.35  E-value: 2.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  42 FVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIYTINFYTSMLI 119
Cdd:cd15199    11 FGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAyfYLNGNRWSLGGGTCKALLFMLSLSRGVSIAF 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 120 LTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGY--HDEAISTVVLATQMT 197
Cdd:cd15199    91 LTAVALDRYFRVVHPRGKKNSLSLQAA--PYISFLVWLLLVGLTIPTLLASQPKNFTECNSFSpkDDEDFSDTWQEAVFF 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 198 LGFFLPLLTMIVCYSVII----KTLLHAGGFQK-HRSLKIIFLVMAVFLLTQMPFNLMK---FIRSTHWEYYAMTSFHYT 269
Cdd:cd15199   169 LQFLLPFGLIVFCTVRIIrrlkKRLRDVGKQPKlQRAMALVTSVVVVFGFCFLPCFLARvlmLIFQNKESCNALNIAVHT 248
                         250       260       270
                  ....*....|....*....|....*....|
gi 1894925283 270 IMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15199   249 YDVTMCLTYLNSVLDPIVYCFSSPTFRSSY 278
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
38-299 2.68e-12

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 66.41  E-value: 2.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVC--TLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd16004     7 YSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAfnTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAynqqakRMTWG--KVTSLLIWVISLLVSLPQIIYGNVFNLD---KLICGYHDEAISTV 190
Cdd:cd16004    87 SIYSMTAIAADRYMAIIHPFKP------RLSAGstKVVIAGIWLVALALAFPQCFYSTVTMDQgrtKCIVAWPGDSGGKH 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLATQMT---LGFFLPLLTMIVCYSVIIKTLL------HAGGFQKHRSL-------KIIFLVMAVFLLTQMPFNLMKFIR 254
Cdd:cd16004   161 QLTYHLAvivLIYLLPLAVMFVTYSIIGITLWrsavpgHQAHGAYHRQLqakkkfvKTMVVVVVTFAICWLPYHLYFILG 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1894925283 255 STHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd16004   241 SFNEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
32-299 5.91e-12

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 65.53  E-value: 5.91e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQS-LTDVFLVNLPLADL-VFVCTLPFWAYAGIHE-WVFGQvMCKSLLGI 108
Cdd:cd15057     1 IITGCILYLLVLLTLLGNALVIAAVLRFRHLRSkVTNYFIVSLAVSDLlVAILVMPWAAVNEVAGyWPFGS-FCDVWVSF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINFYTSMLILTCITVDRFIVVVKATKAYnqqaKRMTwGKVTSLLI---WVISLLVSLPQIIYG--NVFNLDKLICGYH 183
Cdd:cd15057    80 DIMCSTASILNLCVISVDRYWAISSPFRYE----RRMT-RRRAFIMIavaWTLSALISFIPVQLGwhRADDTSEALALYA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 184 DEAISTVVLATQMTLG-----FFLPLLTMIVCYSVI----------IKTLLHAGGFQKH-------------RSLKIIFL 235
Cdd:cd15057   155 DPCQCDSSLNRTYAISsslisFYIPVAIMIVTYTRIyriarrqirrIAALERAAQESTNpdsslrsslrretKALKTLSI 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1894925283 236 VMAVFLLTQMPF---NLMKFIRSTHWEYYAMTSfHYTIMVTEAIAYLRACLNPVLYAFvSLKFRKNF 299
Cdd:cd15057   235 IMGVFVCCWLPFfilNCVLPFCDLRTAQFPCVP-DTTFIVFVWLGWANSSLNPIIYAF-NADFRKAF 299
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
39-299 7.78e-12

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 65.60  E-value: 7.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVcGLVGNSLVLVISIFYHKLQSLTD--VFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIY----TIN 112
Cdd:PHA03235   41 LIISV-GGPLNLIVLVTQLLANRVHGFSTptLYMTNLYLANLLTVFVLPFIMLSNQGLLSGSVAGCKFASLLYyascTVG 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLIltciTVDRFIVVVKATKAyNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNVF---NLDKLICGYHDEAIST 189
Cdd:PHA03235  120 FATVALI----AADRYRVIHQRTRA-RSSAYRSTY--KILGLTWFASLICSGPAPVYTTVVahdDVDPEAPGYETCVIYF 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTLGFFLPLLTMIV----------CYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWE 259
Cdd:PHA03235  193 RADQVKTVLSTFKVLLTLVWgiapvvmmtwFYTFFYRTLKRASYKKRSRTLTFVCILLLSFLCLQTPFVAIMIFDSYATL 272
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1894925283 260 YYAMTSFHYTI-----MVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:PHA03235  273 IWPSDCEHINLrdavsTLSRLVPNLHCLLNPILYAFLGNDFLKRF 317
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
34-297 1.00e-11

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 64.48  E-value: 1.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTdVFLVNLPLADLVFVCTLPF--WAYAGIHEWVFGQVMCKSLLGIYTI 111
Cdd:cd15149     3 IPVFYSLVFIVGILLNGVNFWIFFYVPSNKSFI-VYLKNIVFADLLMSLTFPFkiLSDVELGPWQLNVIVCRYSAVIFYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATkaYNQQAKRMTWGKVTSLLIWVISLLVSLPQII----------YGNVFNLDKLICG 181
Cdd:cd15149    82 NMYVGIIFFGLIGFDRYYKIVKPL--HTSFVQNVGYSKALSVVVWMLMAVLSVPNIIltnqsfheanYTKCARLKSELGI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 182 YHDEAISTVVLATqmtlgFFLPLLTMIVCYSVIIKTLLHA-------GGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIR 254
Cdd:cd15149   160 QWHKASNYICVSI-----FWVVFLLLIIFYVAISRKIYKSnqkfrrnSTNMKAKSSRNIFSILFVFFVCFVPYHALRIPY 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1894925283 255 S-----THWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15149   235 TlsqtgADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFRE 282
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
32-299 1.36e-11

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 64.12  E-value: 1.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISI---FYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGI---HEWVFGQVMCKS 104
Cdd:cd15356     1 VLFTAVYALIWALGAAGNALTIHLVLkkrSLRGLQGTVHYHLVSLALSDlLILLISVPIELYNFVwfhYPWVFGDLVCRG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 105 LLGIYTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQ-IIYGNVFNLD------- 176
Cdd:cd15356    81 YYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRT--KWLLALIWASSLGFALPMaFIMGQKYELEtadgepe 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 177 --KLIC-GYHDEAISTVVLATQMTLGFFLPLlTMIVCYSVIIKTLLHAGGFQkhRSLKIIFLVMAVFLLTQMPFNLMK-- 251
Cdd:cd15356   159 psSRVCtVLVSRATLKVFIQVNAFVSFVLPL-ALIAFLNGVTVSHLRIQSLQ--HSVQVLRAIVIAYVICWLPYHARRlm 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1894925283 252 --FIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15356   236 fcYVPDDAWTDSLYNFYHYFYMLTNTLFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
46-299 1.93e-11

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 63.45  E-value: 1.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  46 LVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWA-YAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTCI 123
Cdd:cd15297    15 IIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIgVFSMNLYTlYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLII 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 124 TVDRFIVVvkaTKAYNQQAKRMTwgKVTSLLI---WVISLLVSLPQIIYGNVFNLDKLI----CGYHDEAISTVVLATQM 196
Cdd:cd15297    95 SFDRYFCV---TKPLTYPVKRTT--KMAGMMIaaaWVLSFILWAPAILFWQFIVGGRTVpegeCYIQFFSNAAVTFGTAI 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 197 TlGFFLPLLTMIVCYSVIIKtllhaGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSthweYYAMTSFHYTIMVTEAI 276
Cdd:cd15297   170 A-AFYLPVIIMTVLYWQISR-----ASSREKKVTRTILAILLAFIITWTPYNVMVLINT----FCASCIPNTVWTIGYWL 239
                         250       260
                  ....*....|....*....|...
gi 1894925283 277 AYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15297   240 CYINSTINPACYALCNATFKKTF 262
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
38-299 2.16e-11

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 63.41  E-value: 2.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVC--TLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd16003     7 YGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAfnTLINFIYALHSEWYFGEAYCRFHNFFPITSVFA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAynqqAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNL-DKLIC-----GYHDEAIST 189
Cdd:cd16003    87 SIYSMTAIAVDRYMAIIDPLKP----RLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMpGRTLCfvawpGGPDQHFTY 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLAtqMTLGFFLPLLTMIVCYSVIIKTL------------LHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTh 257
Cdd:cd16003   163 HIIV--IVLVYCLPLLVMGITYTIVGITLwggeipgdtsdkYHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFIVTGL- 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1894925283 258 weYYAMTSFHYTIMVTEAIAYL---RACLNPVLYAFVSLKFRKNF 299
Cdd:cd16003   240 --YQQLNRWKYIQQVYLASFWLamsSTMYNPIIYCCLNKRFRAGF 282
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
34-299 3.19e-11

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 63.01  E-value: 3.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGIHE-WVFGQVMCKSLLGIYTI 111
Cdd:cd15401     3 LAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVaVYPYPLILLAIFHNgWTLGNIHCQISGFLMGL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVV---VKATKAYNQqakRMTWGKVTslLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAIS 188
Cdd:cd15401    83 SVIGSVFNITAIAINRYCYIchsLRYDKLYNM---KKTCCYVC--LTWVLTLAAIVPNFFVGSLQYDPRIYSCTFAQTVS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLATQMTLGFFLPLLTMIVCYSVI------IKTLLHAGGFQKHRSLKI-----IFLVMAVFLLTQMPFNLMKFIRSTH 257
Cdd:cd15401   158 SSYTITVVVVHFIVPLSIVTFCYLRIwvlviqVKHRVRQDSKQKLKANDIrnfltMFVVFVLFAVCWGPLNFIGLAVAIN 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1894925283 258 WEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15401   238 PLKVAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
39-299 3.23e-11

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 63.16  E-value: 3.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLvISIFYHKLQSLTDV--FLVNLPLADLVFVC-TLPFWAYAGIH-EWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15383     8 FVLFVLSACSNLAVL-WSATRNRRRKLSHVriLILHLAAADLLVTFvVMPLDAAWNVTvQWYAGDLACRLLMFLKLFAMY 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATkAYNQQAKRmtwGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLI----CGYHDEAIS-- 188
Cdd:cd15383    87 SSAFVTVVISLDRHAAILNPL-AIGSARRR---NRIMLCAAWGLSALLALPQLFLFHTVTATPPVnftqCATHGSFPAhw 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 --TVVLATQMTLGFFLPLLTMIVCYSVII---------KTLLHAGGFQKHRS-----------LKIIFLVMAVFLLTQMP 246
Cdd:cd15383   163 qeTLYNMFTFFCLFLLPLLIMIFCYTRILleisrrmkeKKDSAKNEVALRSSsdnipkarmrtLKMTIVIVSSFIVCWTP 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1894925283 247 FNLMKF---IRSTHWEYYAMTSFHYTIMVteaIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15383   243 YYLLGLwywFSPEMLEQTVPESLSHILFL---FGLLNACLDPLIYGLFTISFRRGL 295
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
40-292 3.38e-11

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 63.25  E-value: 3.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV--FVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSM 117
Cdd:cd15388     9 IIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVvaFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVGMFASS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 118 LILTCITVDRFIVVVKATKAYnqQAKRMTWgKVTSLLIWVISLLVSLPQIIygnVFNLDKLICGYHD------EAISTVV 191
Cdd:cd15388    89 YMIVAMTFDRHQAICRPMVTF--QKGRARW-NGPVCVAWAISLILSLPQVF---IFSKVEVAPGVYEcwacfiEPWGLKA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 LATQMTLG-FFLPLLTMIVCYSVIIKTL----------LHAGGFQKHR-----------------SLKIIFLVMAVFLLT 243
Cdd:cd15388   163 YVTWITLVvFVLPTLIITVCQVLIFKEIhiniylksqiIVAVVKKKQLlssrassvaevskamikTVKMTLVIVLVYVLC 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1894925283 244 QMPFNLMKFIRSthWEYYAMT-SFHYTIMVTeaIAYLRACLNPVLYAFVS 292
Cdd:cd15388   243 WAPFFLVQLWSV--WDPKAPTeGATFTILML--LASLNSCTNPWIYMAFS 288
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
40-299 3.69e-11

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 63.14  E-value: 3.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAG--IHEWVFGQVMCKSLLGiYTINFYT-S 116
Cdd:cd15065     8 LIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNdlLGYWLFGETFCNIWIS-FDVMCSTaS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 117 MLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSllIWVISLLVS-LPQ-----------IIYGNVFNLDKLICGYHD 184
Cdd:cd15065    87 ILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIAS--VWILSALISfLPIhlgwhrlsqdeIKGLNHASNPKPSCALDL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVLATqmtLGFFLPLLTMIVCYS----------VIIKTLL----HAGGFQ------KHRSLKI--------IFLV 236
Cdd:cd15065   165 NPTYAVVSSL---ISFYIPCLVMLLIYSrlylyarkhvVNIKSQKlpseSGSKFQvpslssKHNNQGVsdhkaavtLGII 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1894925283 237 MAVFLLTQMPFNLMKFIRSthweyYAMTSF-HYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15065   242 MGVFLICWLPFFIINIIAA-----FCKTCIpPKCFKILTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
33-299 4.76e-11

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 62.49  E-value: 4.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGIHE-WVFGQVMCKSLLGIYT 110
Cdd:cd15209     2 ALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVaIYPYPLILHAIFHNgWTLGQLHCQASGFIMG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVtsLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAISTV 190
Cdd:cd15209    82 LSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYL--CLTWLLTVLAVLPNFFIGSLQYDPRIYSCTFAQTVSTV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLATQMTLGFFLPLLTMIVCY----SVIIKTLLHAGGFQKH-------RSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWE 259
Cdd:cd15209   160 YTITVVVIHFLLPLLIVSFCYlriwVLVLQVRQRVKPDQRPklkpadvRNFLTMFVVFVLFAVCWAPLNFIGLAVAINPK 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 260 YYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15209   240 EMAPKIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
43-297 5.53e-11

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 62.15  E-value: 5.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  43 VCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGIH-EWVFGQVMC------KSLLGIytinfy 114
Cdd:cd15078    12 FLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVsLLGVTFTFMSCVRgRWVFDVAGCvwdgfsNSLFGI------ 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKAtkaynqQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAISTVVLAT 194
Cdd:cd15078    86 VSIMTLTVLAYERYIRVVHA------KVVNFSWSWRAITYIWLYSLAWTGAPLLGWNRYTLEVHGLGCSFDWKSKDPNDT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 195 QMTLGFFL-----PLLTMIVCYSVI---IKTLLHAGGFQKHRSLKII----------FLVMAVFLLTQMPFNLMKFirst 256
Cdd:cd15078   160 SFVLLFFLgclvvPLGIMAYCYGHIlyeIRMLRSVEDLQTFQVIKILkyekkvakmcLLMISTFLICWMPYAVVSL---- 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1894925283 257 hweyyaMTSFHYTIMVTEAIAYL-------RACLNPVLYAFVSLKFRK 297
Cdd:cd15078   236 ------LVTSGYSKLVTPTIAIIpslfaksSTAYNPVIYIFMIRKFRQ 277
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
36-299 5.72e-11

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 62.19  E-value: 5.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVF---VCGLVGNSLVlVISIFYHK-LQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGIHE-WVFGQVMCKSLLGIY 109
Cdd:cd15055     2 LLYIVLSsisLLTVLGNLLV-IISISHFKqLHTPTNLLLLSLAVADfLVGLLVMPFSMIRSIETcWYFGDTFCKLHSSLD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVK----ATKAYNQQAKRMTwgkvtsLLIWVISLLVSLPqIIYGNVFNLDKLICGY-HD 184
Cdd:cd15055    81 YILTSASIFNLVLIAIDRYVAVCDpllyPTKITIRRVKICI------CLCWFVSALYSSV-LLYDNLNQPGLIRYNScYG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 E---AISTVVLATQMTLGFFLPLLTMIVCYSVI----------IKTLLHAGGFQK----------HRSLKIIFLVMAVFL 241
Cdd:cd15055   154 EcvvVVNFIWGVVDLVLTFILPCTVMIVLYMRIfvvarsqaraIRSHTAQVSLEGsskkvskkseRKAAKTLGIVVGVFL 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1894925283 242 LTQMPFnlmkFIRSTHWEYYAMTSFHYTIMVTeaIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15055   234 LCWLPY----YIVSLVDPYISTPSSVFDVLIW--LGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
38-298 6.35e-11

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 62.29  E-value: 6.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPFWAYAGI-HEWVFGQVMCKsLLGIYTINF-Y 114
Cdd:cd15074     7 LTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLgISVFGYPLAIISAFaHRWLFGDIGCV-FYGFCGFLFgC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgkVTSLLIWVISLLVSLPQI---------IYGNVFNLDklICGYHDE 185
Cdd:cd15074    86 CSINTLTAISIYRYLKICHPPYGPKLSRRHVC---IVIVAIWLYALFWAVAPLvgwgsygpePFGTSCSID--WTGASAS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMTLGFFLPLLTMIVCYSVIIKTL-------LHAGGFQKHRS------LKIIFLVMAVFLLTQMPFNLMKF 252
Cdd:cd15074   161 VGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVkssrkrvAGFDSRSKRQHkierkvTKVAVLICAGFLIAWTPYAVVSM 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1894925283 253 iRSTHWEYY---AMTSFHYTIMVTEAIAYlraclNPVLYAFVSLKFRKN 298
Cdd:cd15074   241 -WSAFGSPDsvpILASILPALFAKSSCMY-----NPIIYLLFSSKFRQD 283
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
38-298 9.23e-11

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 61.75  E-value: 9.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPF-WAYAGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15395     7 YSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDlLMTIMCLPFtFVYTLMDHWVFGEAMCKLNSMVQCISITV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDR--FIVVVKATKAYNQQAkrmtwgKVTSLLIWVISLLVSLPQIIYGNVFN-------------LDKLIC 180
Cdd:cd15395    87 SIFSLVLIAIERhqLIINPRGWRPNNRHA------YVGIAVIWVLAVLTSLPFLIFQVLTDepfknvnvsldayKGKYVC 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 181 --GYHDEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGF------QKHRSLK------IIFLVMAVFLLTQMP 246
Cdd:cd15395   161 ldQFPSDTIRLSYTTCLLVLQYFGPLCFIFICYLKIYIRLKRRNNMmdkmrdNKYRSSEtkriniMLISIVVAFAVCWLP 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1894925283 247 FNLMKFIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKN 298
Cdd:cd15395   241 LNIFNAVFDWNHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQRD 292
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
48-299 1.03e-10

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 61.85  E-value: 1.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  48 GNSLVLVISIFYHKLQSLTDVFLVNLPLADLV--FVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTCITV 125
Cdd:cd15959    17 GNLLVIVAIAKTPRLQTMTNVFVTSLACADLVmgLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASIETLCAIAV 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 126 DRFIVVVKATKAYNQQAKRMTWGKVtsLLIWVISLLVSLPQIIygNVFNLDklicGYHDEAIS------TVVLATQM--- 196
Cdd:cd15959    97 DRYLAITNPLRYEALVTKRRARTAV--CLVWAISAAISFLPIM--NQWWRD----GADEEAQRcydnprCCDFVTNMpya 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 197 ----TLGFFLPLLTMIVCYS----VIIKTLLHAGG----------------------------FQKHRSLKIIFLVMAVF 240
Cdd:cd15959   169 ivssTVSFYVPLLVMIFVYVrvfvVATRQVRLIRKdkvrfppeesppaesrpacgrrpsrllaIKEHKALKTLGIIMGTF 248
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1894925283 241 LLTQMPFNLMKFIRSTHWEYYAMTSFhytiMVTEAIAYLRACLNPVLYAfVSLKFRKNF 299
Cdd:cd15959   249 TLCWLPFFVANIIKVFCRSLVPDPAF----LFLNWLGYANSAFNPIIYC-RSPDFRSAF 302
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
32-299 1.16e-10

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 61.14  E-value: 1.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF--VCTLPFWAYAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd17790     1 VLIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIgaFSMNLYTTYILMGHWALGTVACDLWLALD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVvkaTKAYNQQAKRMTwgKVTSLLI---WVISLLVSLPQIIYGNVFNLDKLI----CGY 182
Cdd:cd17790    81 YVASNASVMNLLIISFDRYFSI---TRPLTYRAKRTP--RRAAIMIglaWLISFVLWAPAILFWQYLVGERTVlagqCYI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 183 HDEAISTVVLATQMTlGFFLPLLTMIVCYSVIIKTLLhaggfQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRS------- 255
Cdd:cd17790   156 QFLSQPIITFGTAIA-AFYLPVTIMIILYWRIYRETI-----KEKKAARTLSAILLAFILTWTPYNIMVLVSTfckdcvp 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1894925283 256 -THWE--YYamtsfhytimvteaIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd17790   230 kTLWElgYW--------------LCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
32-292 1.37e-10

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 61.12  E-value: 1.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTdVFLVNLPLADLVFVCTLPFWAYAGIHE-WVFGQVMCKSLLGIYT 110
Cdd:cd14973     1 LVIFSLTVLLSLCGLVGNGLVLWLLGFRIKRNPFS-VYILNLAAADFLFLSCQAIQSLEDLLGgSLPGFALCRLLATLMF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNVFNL--DKLICGYHDEAIs 188
Cdd:cd14973    80 FSYTVGLSLLAAISTERCLSVLFPIWYRCHRPKHLS--AVVCALLWALSLLLSVLESYFCGFLFWkfNESACRTFNFLS- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 tvvlatqmTLGFFLPLLTMIVCYSVIIKTLLHagGFQKHRSLKIIFLVMA---VFLLTQMPFNLMKFIRSTHWEYYAMTS 265
Cdd:cd14973   157 --------ALLFLLLFLVMCVSSLTLLIRVQC--SSQRRPPTRLYVVILLtvlVFLLCGLPLGIYWFLLLWFSNYLFHTF 226
                         250       260
                  ....*....|....*....|....*..
gi 1894925283 266 FHYTIMvteaIAYLRACLNPVLYAFVS 292
Cdd:cd14973   227 HPISDL----LSCVNSSANPIIYFFVG 249
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
37-299 1.60e-10

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 60.73  E-value: 1.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGL------VGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF--VCTLPFWAYAGIHEWVFGQVMCKSLLGI 108
Cdd:cd15299     3 VVLIAFLTGIlalvtiIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIgvISMNLFTTYIIMNRWALGNLACDLWLSI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINFYTSMLILTCITVDRFIVVvkaTKAYNQQAKRMT-WGKVTSLLIWVISLLVSLPQIIYGNVFN------LDKLICG 181
Cdd:cd15299    83 DYVASNASVMNLLVISFDRYFSI---TRPLTYRAKRTTkRAGVMIGLAWVISFVLWAPAILFWQYFVgkrtvpPDECFIQ 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 182 YHDEAISTVVLATQmtlGFFLPLLTMIVCYSVIIKTLLhaggfQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYY 261
Cdd:cd15299   160 FLSEPIITFGTAIA---AFYLPVTIMTILYWRIYKETI-----KEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCI 231
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1894925283 262 AMTSFHytimVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15299   232 PKTYWN----LGYWLCYINSTVNPVCYALCNKTFRTTF 265
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
37-299 2.04e-10

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 60.65  E-value: 2.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWAYA--GIHEWVFGQVMCKSLLGIYTINF 113
Cdd:cd15357     6 VYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDlLVLLFGMPLEVYEmwSNYPFLFGPVGCYFKTALFETVC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGkvTSLLIWVISLLVSLPQI-IYGNVFNLDKLICGYHDEAISTVV- 191
Cdd:cd15357    86 FASILSVTTVSVERYVAILHPFRAKLNSTRERALK--IIVVLWVLSVLFSIPNTsIHGIKLQYFPNGTLIPDSATCTVVk 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 ------LATQMT--LGFFLPLLTMIVCYsviiktLLHAGGFQKHRSL------------------KIIFLVMAVFLLTQM 245
Cdd:cd15357   164 plwiynLIIQITslLFYVLPMGVISVLY------YLMGLKLRGDKSLeademnvniqrpsrksvtKMLFVLVLVFAICWA 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1894925283 246 PFNLMKFIRS--THWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15357   238 PFHVDRLFFSfvVEWTEPLANVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
38-297 2.09e-10

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 60.52  E-value: 2.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVF-VCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPFWAYAGIH-EWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15073     6 YLIVAgIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLgVSIIGYPFSAASDLHgSWKFGYAGCQWYAFLNIFFGM 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgkVTSLLIWVISLLVSLPQIIYGNVFNLDK-----LICGYHDEAIST 189
Cdd:cd15073    86 ASIGLLTVVAVDRYLTICRPDLGRKMTTNTYT---VMILLAWTNAFFWAAMPLVGWASYALDPtgatcTINWRKNDSSFV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGG------------FQKHRSlKIIFLVMAVFLLTQMPFNLMkFIRSTH 257
Cdd:cd15073   163 SYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLAsdclesvnidwtDQNDVT-KMSVIMIVMFLVAWSPYSIV-CLWASF 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 258 WEYYAMTSFhyTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15073   241 GEPKKIPPW--MAIIPPLFAKSSTFYNPCIYVIANKKFRR 278
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
36-288 2.47e-10

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 60.53  E-value: 2.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV--FVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINF 113
Cdd:cd15384     5 VVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLvtFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTslliWVISLLVSLPQIIYGNV----FNLDKLIC---GYHDEA 186
Cdd:cd15384    85 YLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVA----WILSPIFSIPQAVIFHVergpFVEDFHQCvtyGFYTAE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLAT-QMTLGFFLPLLTMIVCYSVIIKTLL-HAGGFQ--------------------KHRSLKIIFLVMAVFLLTQ 244
Cdd:cd15384   161 WQEQLYNMlSLVFMFPIPLVIMVTCYVLIFITLSkSSRDFQgleiytrnrgpnrqrlfhkaKVKSLRMSAVIVTAFILCW 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1894925283 245 MPFNLMkFIRSTHWEYYAMTSFHYTIMVTEAIAylRACLNPVLY 288
Cdd:cd15384   241 TPYYVI-MIWFLFFNPYPLNDILFDVIFFFGMS--NSCVNPLIY 281
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
49-299 2.63e-10

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 59.96  E-value: 2.63e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  49 NSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPF-WAYAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTCITVD 126
Cdd:cd15334    18 NSLVITAIIVTRKLHHPANYLICSLAVTDfLVAVLVMPFsIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALD 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 127 RFIVVVKATKAYNQQAKRMTWGKVTslLIWVISLLVSLPQIIYGN-VFNLDKLICGYHDEAISTVVlatqMTLG-FFLPL 204
Cdd:cd15334    98 RYRAITDAVEYARKRTPKHAGIMIA--VVWIISIFISMPPLFWRHqTTSREDECIIKHDHIVFTIY----STFGaFYIPL 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 205 LTMIVCYSVIIKtllhaGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYA---MTSFhytimvTEAIAYLRA 281
Cdd:cd15334   172 ALILILYYKIYR-----AATRERKAATTLGLILGAFVICWLPFFVKEVIVNTCDSCYIseeMSNF------LTWLGYINS 240
                         250
                  ....*....|....*...
gi 1894925283 282 CLNPVLYAFVSLKFRKNF 299
Cdd:cd15334   241 LINPLIYTIFNEDFKKAF 258
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-299 3.15e-10

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 60.30  E-value: 3.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVIsIFYHK-LQSLTDVFLVNLPLADLVFV-CTLPFWAYAGIHE-WVFGQVMCKSLLGIYTINFYTS 116
Cdd:cd15977     9 VIFLVGIIGNSTLLRI-IYKNKcMRNGPNVLIASLALGDLLYIlIAIPINVIKLIAEdWPFGVHVCKLYPFIQKASVGIT 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 117 MLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDK-----LICGYHDEAISTVV 191
Cdd:cd15977    88 VLSLCALSIDRYRAVASWSRI--RGIGIPVWKAVEVTLIWAVAIIVAVPEAIAFDMVEIDYrgqtlLVCMLPMEQTSSFM 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 LATQ-----MTLGFF--LPLLTMIVCYSVI----------IKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMK-FI 253
Cdd:cd15977   166 RFYQdvkdwWLFGFYfcLPLACTGVFYTLMscemlsikngMRIALNDHMKQRREVAKTVFCLVVIFALCWLPLHLSRiLK 245
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1894925283 254 RSTHWEYYAMTSFHYTIMVTE-----AIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15977   246 KTIYDVKDPQRCELLSFLLVMdytgiNMASLNSCINPVALYFVSRKFKNCF 296
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
47-299 3.20e-10

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 59.84  E-value: 3.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  47 VGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVC-TLP-FWAYAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTCIT 124
Cdd:cd15301    16 GGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGViSMPlFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLLIIS 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 125 VDRFIVVvkaTKAYNQQAKRMTwgKVTSLLI---WVISLLVSLPQII----YGNVFNLDKLICGYHDEAISTVVLATQMT 197
Cdd:cd15301    96 FDRYFSV---TRPLTYRARRTT--KKAAVMIasaWIISLLLWPPWIYswpyIEGKRTVPAGTCYIQFLETNPYVTFGTAL 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 198 LGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYTIMVteAIA 277
Cdd:cd15301   171 AAFYVPVTIMCILYWRIWRETKKRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFFPCSDTIPTELWDFSY--YLC 248
                         250       260
                  ....*....|....*....|..
gi 1894925283 278 YLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15301   249 YINSTINPLCYALCNAAFRRTY 270
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
47-299 3.78e-10

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 59.64  E-value: 3.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  47 VGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWA-YAGIHEWVFGQVMCKSLLGI-YTINFYTSMLILTcI 123
Cdd:cd15049    16 GGNILVILSFRVNRQLRTVNNYFLLSLACADLIIgLVSMNLYTvYLVMGYWPLGPLLCDLWLALdYVASNASVMNLLL-I 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 124 TVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQII----YGNVFNLDKLIC--GYHDEAISTVVLATqmt 197
Cdd:cd15049    95 SFDRYFSVTRPLTYRAKRTPKRA--ILMIALAWVISFVLWAPAILgwqyFVGERTVPDGQCyiQFLDDPAITFGTAI--- 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 198 LGFFLPLLTMIVCYSVIIKTLLhaggfQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFhytiMVTEAIA 277
Cdd:cd15049   170 AAFYLPVLVMTILYWRIYRETA-----RERKAARTLSAILLAFIITWTPYNILVLVSTFCAKCIPDTLW----SFGYWLC 240
                         250       260
                  ....*....|....*....|..
gi 1894925283 278 YLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15049   241 YINSTINPFCYALCNKTFRKTF 262
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
34-299 4.71e-10

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 59.48  E-value: 4.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVC-TLPFWAYAGIH-EWVFGQVMCKSLLGIYTI 111
Cdd:cd15400     3 LSSVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALyPYPLVLVAIFHnGWALGEMHCKVSGFVMGL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTslLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAISTVV 191
Cdd:cd15400    83 SVIGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVC--LIWALTVVAIVPNFFVGSLEYDPRIYSCTFVQTASSSY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 LATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKH-----------RSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEY 260
Cdd:cd15400   161 TIAVVVIHFIVPITVVSFCYLRIWVLVIQVRRKVKSeskprlkpsdfRNFLTMFVVFVIFAICWAPLNLIGLAVAINPQE 240
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1894925283 261 YAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15400   241 MAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
32-297 5.00e-10

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 59.41  E-value: 5.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVIsIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAY--AGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15151     1 VVFPVLYTVLFLVGLILNSVAAWI-FFHIPSTSTFIVYLKNTLVADLIMTLMLPFKILsdSGLGPWQLRAFVCRFSAVVF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKayNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGN-------VFNLDKLICGY 182
Cdd:cd15151    80 YITMYISIILLGLISFDRYLKIVRPFG--KSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNkpatpisVKKCASLKSPL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 183 HDEAISTVVLATQMTlgFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKI-------IFLVMAVFLLTQMPFNlmkFIR- 254
Cdd:cd15151   158 GLKWHEVVNYICQFI--FWGVFALMVLFYTIISKKVYESYKKSRSKDNKAskktkakVFIIVAVFFVCFAPFH---FVRv 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1894925283 255 -------STHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15151   233 pytlsqtGKITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQ 282
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
32-296 6.69e-10

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 59.08  E-value: 6.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGIH-EWVFGQVMCKSLLGIY 109
Cdd:cd15404     1 VILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLaVLNMPFALVTIITtRWIFGDAFCRVSAMFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAkrmtwGKVTSLLIWVISLLVSLPQIIYGNVFNLD----KLICGYHDE 185
Cdd:cd15404    81 WLFVMEGVAILLIISIDRFLIIVQKQDKLNPYR-----AKVLIAVSWAVSFCVAFPLAVGSPDLQIPsrapQCVFGYTTN 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAggfqKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTS 265
Cdd:cd15404   156 PGYQAYVILIMLIFFFIPFMVMLYSFMGILNTVRSF----KTRAFTTILILFIVFTVCWAPFTTYSLVATFNSHFYHKHN 231
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1894925283 266 FHYTIMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15404   232 FFEISTWLLWLCYLKSALNPLIYYWRIKKFR 262
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
37-299 8.96e-10

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 58.42  E-value: 8.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFvcglvGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPF-WAYAGIHEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15322    11 MLLTVF-----GNVLVIIAVFTSRALKAPQNLFLVSLASADiLVATLVIPFsLANEVMGYWYFGKVWCEIYLALDVLFCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIY--GNVFNLDKLICGYHDEAISTVvl 192
Cdd:cd15322    86 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRI--KCIIFIVWVISAVISFPPLITieKKSGQPEGPICKINDEKWYII-- 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 193 aTQMTLGFFLPLLTMIVCYSVIIKtllhaggFQKHRSLKIIF---LVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYT 269
Cdd:cd15322   162 -SSCIGSFFAPCLIMVLVYIRIYQ-------IAKNREKRFTFvlaVVIGVFVICWFPFFFTYTLTAVCDCSVPETLFKFF 233
                         250       260       270
                  ....*....|....*....|....*....|
gi 1894925283 270 IMvteaIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15322   234 FW----FGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
39-296 9.77e-10

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 58.27  E-value: 9.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLP---FWAYAGihewvfGQVMCKSLLGI--YTINF 113
Cdd:cd15163     8 TLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLPtriVMYYSA------GNCLTCSFVHIfsYFVNM 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFnldklicgyhdEAISTVVLA 193
Cdd:cd15163    82 YCSILFLTCICVDRYLAIVQVEAS--RRWRNPNYAKGICVFIWLFAIVVTFSILTTAIKF-----------ASCCLSKLF 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 194 TQMTLGFFLPLLTMIVCYSVII-----KTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFhY 268
Cdd:cd15163   149 ALTVFEFFLPLLIITFFTIRIMcalsrPGLMHQSRERRMRAVQLLITVLIIFMICFTPFHVRQVAVAFNPDIPHHTSL-I 227
                         250       260
                  ....*....|....*....|....*...
gi 1894925283 269 TIMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15163   228 VYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
37-299 1.24e-09

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 58.41  E-value: 1.24e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVisIFYHK-LQSLTDVFLVNLPLADLVF-VCTLPFWA----YAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd14978     6 VLPVICIFGIIGNILNLV--VLTRKsMRSSTNVYLAALAVSDILVlLSALPLFLlpyiADYSSSFLSYFYAYFLPYIYPL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INF--YTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLP-----QIIYGNVFNLDKLICGYH 183
Cdd:cd14978    84 ANTfqTASVWLTVALTVERYIAVCHPLKA--RTWCTPRRARRVILIIIIFSLLLNLPrffeyEVVECENCNNNSYYYVIP 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 184 DEAI------STVVLATQMTLGFFLPLLTMIVCYSVIIKTL----------------LHAGGFQKHRSLKIIFLVMAVFL 241
Cdd:cd14978   162 TLLRqnetylLKYYFWLYAIFVVLLPFILLLILNILLIRALrkskkrrrllrrrrrlLSRSQRRERRTTIMLIAVVIVFL 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1894925283 242 LTQMPFNLMKFIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14978   242 ICNLPAGILNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
32-299 1.34e-09

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 58.26  E-value: 1.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF--VCTLPFWAYAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15296     1 VILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVggFCIPLYIPYVLTGRWKFGRGLCKLWLVVD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAkrMTWGKVTS-LLIWVISLLVSLPQIIYGNVFNLDKLI----CgYHD 184
Cdd:cd15296    81 YLLCTASVFNIVLISYDRFLSVTRAVSYRAQKG--MTRQAVLKmVLVWVLAFLLYGPAIISWEYIAGGSIIpegeC-YAE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVLATQMTLGFFLPLLTmIVCYSVIIKTLLHAGGFQKHRSLKI---IFLVMAVFLLTQMPFNLMKFIRSTH---- 257
Cdd:cd15296   158 FFYNWYFLMTASTLEFFTPFIS-VTYFNLSIYLNIQKRRFRLSRDKKVaksLAIIVCVFGLCWAPYTLLMIIRAAChghc 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1894925283 258 -WEYYAMTSFHytimvteaIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15296   237 vPDYWYETSFW--------LLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
38-299 1.41e-09

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 58.36  E-value: 1.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV--FVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15980     7 YLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLvgIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKaynqQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLD--KLICGYHDEA------- 186
Cdd:cd15980    87 SVFTLVAIAVDRFRCIVYPFK----QKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKnyRVVLGSQNKTspvywcr 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ----------ISTVVLATQMTLGfflPLLTMIVCYSVIIKTLL---------------HAGGFQKHRSLKIIFLVMAVFL 241
Cdd:cd15980   163 edwpnqemrkIYTTVLFANIYLA---PLSLIVIMYARIGITLFktamphtgkhnqeqrHVVSRKKQKVIKMLLIVALLFI 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1894925283 242 LTQMPF----NLMKFIRSTHWEYYAMTSFHYTImvTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15980   240 LSWLPLwtlmMLSDYANLSPNQLQIINIYIYPF--AHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
39-299 1.48e-09

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 57.99  E-value: 1.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGIHE--WVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15305     8 LIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADmLVGILVMPVSLIAILYDyaWPLPRYLCPIWISLDVLFSTA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATK--AYNQQAKRMTwgKVTSllIWVISLLVSLPQIIYGnVFNLDKL----ICGYHDEAIst 189
Cdd:cd15305    88 SIMHLCAISLDRYVAIRNPIEhsRFNSRTKAMM--KIAA--VWTISIGISMPIPVIG-LQDDEKVfvngTCVLNDENF-- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMtlGFFLPLLTMIVCYSVIIKTLLHAGGFQ-KHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHY 268
Cdd:cd15305   161 VLIGSFV--AFFIPLIIMVITYCLTIQVLQRQQAINnERRASKVLGIVFFLFLIMWCPFFITNILSVLCKEACDQKLMEE 238
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1894925283 269 TIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15305   239 LLNVFVWVGYVSSGINPLVYTLFNKTYRRAF 269
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
39-304 2.08e-09

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 57.65  E-value: 2.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPFWAYAGIH-EWVFGQVMCKSLLGIYTINFYTS 116
Cdd:cd15307     8 LVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLmVAVLVMPLGILTLVKgHFPLSSEHCLTWICLDVLFCTAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 117 MLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVtsLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAISTVVLATQM 196
Cdd:cd15307    88 IMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKI--VFVWLLSIAMSLPLSLMYSKDHASVLVNGTCQIPDPVYKLVGSI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 197 tLGFFLPLLTMIVCYSVIIKTLLHAGGFQ------KHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSfHYTI 270
Cdd:cd15307   166 -VCFYIPLGVMLLTYCLTVRLLARQRSRHgriirlEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERIS-HWVF 243
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1894925283 271 MVTEAIAYLRACLNPVLYAFVSLKFRKNFWKLVK 304
Cdd:cd15307   244 DVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLL 277
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
40-299 2.47e-09

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 57.36  E-value: 2.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPFWAYAGI-HEWVFGQVMCKSLLGIYTINFYTSM 117
Cdd:cd15331     9 LLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLmVAVLVMPLSAVYEVsQHWFLGPEVCDMWISMDVLCCTASI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 118 LILTCITVDRFIVVVKATKAYNQQAKRMTwgkVTSLLIWVISLLVSLPQIIygnvfnldklicGYHDEAISTVVLATQMT 197
Cdd:cd15331    89 LHLVAIALDRYWAVTNIDYIRRRTAKRIL---IMIAVVWFVSLIISIAPLF------------GWKDEDDLDRVLKTGVC 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 198 L--------------GFFLPLLTMIVCYSVIIKTLLHaggfqKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSThweYYAM 263
Cdd:cd15331   154 LisqdygytifstvgAFYVPLLLMIIIYWKIYQAAKR-----ERKAARTLAIITGAFVVCWLPFFLVALVMPF---CGAW 225
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1894925283 264 TSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15331   226 QISRFLESFFLWLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
34-299 2.71e-09

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 57.22  E-value: 2.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGIHE-WVFGQVMCKS---LLGI 108
Cdd:cd15402     3 LACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVaIYPYPLVLTSIFHNgWNLGYLHCQIsgfLMGL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINfytSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVtsLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAIS 188
Cdd:cd15402    83 SVIG---SIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYV--LLIWVLTVAAIVPNLFVGSLQYDPRIYSCTFAQSVS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKH-----------RSLKIIFLVMAVFLLTQMPFNLMKFIRSTH 257
Cdd:cd15402   158 SAYTIAVVFFHFILPIIIVTFCYLRIWILVIQVRRRVKPdnkpklkphdfRNFVTMFVVFVLFAVCWAPLNFIGLAVAVD 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1894925283 258 WEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15402   238 PETIVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRREY 279
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
40-299 3.22e-09

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 56.96  E-value: 3.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL---VFVCTLpFWAYAGIHEWVFGQVMCKSLLGIYTINFYTS 116
Cdd:cd15300     9 VVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLiigIFSMNL-YTSYILMGYWALGSLACDLWLALDYVASNAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 117 MLILTCITVDRFIVVvkaTKAYNQQAKRM-TWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLI----CGYHDEAISTVV 191
Cdd:cd15300    88 VMNLLVISFDRYFSI---TRPLTYRAKRTpKRAGIMIGLAWLISFILWAPPILCWQYFVGKRTVpereCQIQFLSEPTIT 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 LATQMTlGFFLPLLTMIVCYSVIIKTLLhaggfQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHytim 271
Cdd:cd15300   165 FGTAIA-AFYIPVSVMTILYCRIYKETI-----KERKAAQTLSAILLAFIITWTPYNIMVLVSTFCSDCIPLTLWH---- 234
                         250       260
                  ....*....|....*....|....*...
gi 1894925283 272 VTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15300   235 LGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-299 3.38e-09

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 57.17  E-value: 3.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV-FVCTLPFWAYAGIHE-WVFGQVMCKSLLGIYTINFYTSM 117
Cdd:cd15976     9 LVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLhIIIDIPINVYKLLAEdWPFGVEMCKLVPFIQKASVGITV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 118 LILTCITVDRFIVVvkATKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDK-----LICGYHDEAISTVVL 192
Cdd:cd15976    89 LSLCALSIDRYRAV--ASWSRIKGIGVPKWTAVEIVLIWVVSIILAVPEAIGFDMITMDYkgellRICLLHPIQKTAFMQ 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 193 ATQM-------TLGFFLPLLTMIVCYSVIIKTLLHAGG----------FQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRS 255
Cdd:cd15976   167 FYKTakdwwlfSFYFCLPLACTAVFYTLMTCEMLRKKNgmqialndhlKQRREVAKTVFCLVLVFALCWLPLHLSRILKL 246
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1894925283 256 THWEYY-----AMTSFHYTI-MVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15976   247 TIYDEKdpnrcELLSFFLVLdYIGINMASLNSCINPIALYLVSKRFKNCF 296
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
32-297 3.73e-09

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 57.17  E-value: 3.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGIH-EWVFGQVMCKSLLGIY 109
Cdd:cd15403     1 ILLAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLsLLCMPFTAVTIITvDWHFGAHFCRISAMLY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAkrmtwGKVTSLLIWVISLLVSLPQIIYGNVFNLD----KLICGYHDE 185
Cdd:cd15403    81 WFFVLEGVAILLIISVDRFLIIVQRQDKLNPHR-----AKVMIAISWVLSFCISFPSVVGWTLVEVParapQCVLGYTES 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMTLGFFLPLLTMIVCYSVIIKTL---------------------LHAGGFQ-----------KHRSLKII 233
Cdd:cd15403   156 PADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVrrnavrihnhadslclsqvskLGLMGLQrphqmnvdmsfKTRAFTTI 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1894925283 234 FLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15403   236 LILFVGFSLCWLPHTVFSLLSVFSRRFYYSSSFYPISTCVLWLSYLKSVFNPVIYCWRIKKFRE 299
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
33-247 4.13e-09

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 56.49  E-value: 4.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCglVGNsLVLVISIFYHK-LQSLTDVFLVNLPLADLVF-VCTLPFWAYAGI-HEWVFGQVMCKSLLGIY 109
Cdd:cd15214     3 SIAIIIIAILIC--LGN-LVIVVTLYKKSyLLTLSNKFVFSLTLSNLLLsVLVLPFVVTSSIrREWIFGVVWCNFSALLY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVV----VKATKAYNQQAkrmtwgKVTSLLIWVISLLVSLPQIIYGNVFNLDKL----ICG 181
Cdd:cd15214    80 LLISSASMLTLGAIAIDRYYAVlypmVYPMKITGNRA------VLALVYIWLHSLIGCLPPLFGWSSLEFDRFkwmcVAA 153
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1894925283 182 YHDEAISTVVLATQMTLgffLPLLTMIVCYSVIIKTllhAGGFQkHRSLKIIFLVMAVFLLTQMPF 247
Cdd:cd15214   154 WHKEAGYTAFWQVWCAL---LPFVVMLVCYGFIFRV---ARANQ-CKAFITILVVLGAFVTTWGPY 212
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
32-299 6.04e-09

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 56.29  E-value: 6.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWA--YAGIHEWVFGQVMCKSLLGI 108
Cdd:cd15302     1 ILLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIgLESMPFYTvyVLNGDYWPLGWVLCDLWLSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTslLIWVISLLVSLPQIIYGNVFNLDKLICGYHD---E 185
Cdd:cd15302    81 DYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIA--ITWIIPALLFFISIFGWQYFTGQGRSLPEGEcyvQ 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMTLGFF-LPLLTMIVCYSVIIKTLLHAggfqkHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMT 264
Cdd:cd15302   159 FMTDPYFNMGMYIGYYwTTLIVMLILYAGIYRAANRA-----RKALRTITFILGAFVICWTPYHILATIYGFCEAPPCVN 233
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1894925283 265 SFHYtiMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15302   234 ETLY--TISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
37-299 1.31e-08

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 54.94  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV---FVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINF 113
Cdd:cd15304     6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLlgfLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVvkATKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYG-----NVFnlDKLICGYHDEAIS 188
Cdd:cd15304    86 TASIMHLCAISLDRYIAI--RNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGlqddsKVF--KEGSCLLADENFV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVvlatQMTLGFFLPLLTMIVCYSVIIKTLLHAGGfQKHRSLKIIFLVMAVFLLTQMPF---NLMKFIRSTHWEYYAMTS 265
Cdd:cd15304   162 LI----GSFVAFFIPLTIMVITYFLTIKSLQQSIS-NEQKASKVLGIVFFLFVVMWCPFfitNVMAVICKESCNEVVIGG 236
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1894925283 266 FhytIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15304   237 L---LNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-292 1.44e-08

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 55.12  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL----VFVCTLPFWAYAGihEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15197     8 WVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLcvglINVLTDIIWRITV--EWRAGDFACKVIRYLQVVVTY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAynqqakrMTWGKVTSLLI---WVISLLVSLPQIIygnVFNLDKLICG-------YHD 184
Cdd:cd15197    86 ASTYVLVALSIDRYDAICHPMNF-------SQSGRQARVLIcvaWILSALFSIPMLI---IFEKTGLSNGevqcwilWPE 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQ-------------------------KHRSLKIIFLVMAV 239
Cdd:cd15197   156 PWYWKVYMTIVAFLVFFIPATIISICYIIIVRTIWKKSKIQvtinkaglhdgssrrsssrgiipraKIKTIKMTFVIVTV 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1894925283 240 FLLTQMPFNLMKFIRSTHWEYYAMTSFHYTIMVtEAIAYLRACLNPVLYAFVS 292
Cdd:cd15197   236 FIICWSPYFVFDLLDVFGLLPRSKTKIAAATFI-QSLAPLNSAINPLIYCLFS 287
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
32-299 1.44e-08

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 55.19  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd14996     1 VALPIIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAayFLKGFYWKYQSTQCRIANFFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 T----INFYTSMLILTCITVDRFIVVVKATKAYNQQA--KRMTWGKVTS------------LLIWVISLLVSLPQIIYGN 171
Cdd:cd14996    81 TlvihVSMCVSILILSWIAISRYATLMKHDSATQKQScyEKIFYGHFLKrfrqpkfarylcIYIWGVVLCIIIPVVVYYS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 172 VFNLD----KLICGYHDE--AISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLH-------AGGFQKHRSLKI-IFLVM 237
Cdd:cd14996   161 VREADedgeSLCYNRQVElgAKGSQIAGLIATTFFFLFFLVVLLSYYSFVNHLRRiqkntciSEKDLIYRSVKRnILIIQ 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1894925283 238 AVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYTIMVTE---AIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14996   241 ALLVVCFLPYHIFKPVFYVLHQREDCQQLNYLIETKNiltCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
46-299 1.73e-08

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 54.64  E-value: 1.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  46 LVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL---VFVCTLpFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTC 122
Cdd:cd15298    15 VVGNILVMLSIKVNRQLQTVNNYFLFSLACADLiigAFSMNL-YTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLI 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 123 ITVDRFIVVvkaTKAYNQQAKRMTwgKVTSLLI---WVISLLVSLPQIIYGNVFNLDKLI----CGYHDEAISTVVLATQ 195
Cdd:cd15298    94 ISFDRYFCV---TKPLTYPARRTT--KMAGLMIaaaWVLSFVLWAPAILFWQFVVGKRTVpdnqCFIQFLSNPAVTFGTA 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 196 MTlGFFLPLLTMIVCYSVIikTLLHAggfQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSthweyYAMTSFHYTI-MVTE 274
Cdd:cd15298   169 IA-AFYLPVVIMTVLYIHI--SLASA---RERKVTRTIFAILLAFILTWTPYNVMVLVNT-----FCQSCIPDTVwSIGY 237
                         250       260
                  ....*....|....*....|....*
gi 1894925283 275 AIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15298   238 WLCYVNSTINPACYALCNATFKKTF 262
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
28-299 2.86e-08

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 54.03  E-value: 2.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  28 QFSKVFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPF-WAYAGIHEWVFGQVMCKSL 105
Cdd:cd15333     1 LGLKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDlLVSILVMPIsIVYTVTGTWTLGQVVCDIW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 106 LGIYTINFYTSMLILTCITVDRFIVVVKATkaynQQAKRMTWGK--VTSLLIWVISLLVSLPQIIYGNVFNLDKL-ICGY 182
Cdd:cd15333    81 LSSDITCCTASILHLCVIALDRYWAITDAV----EYSKKRTPKRaaVMIALVWVISISISLPPFFWRQAKAEEEVsECVV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 183 HDEAISTVVLATqmTLGFFLPLLTMIVCYSVIIKtllhAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFI----RSTHW 258
Cdd:cd15333   157 NTDHILYTVYST--VGAFYIPTLLLIALYGRIYV----EARARERKATKTLGIILGAFIVCWLPFFIISLVlpicKDACW 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1894925283 259 EYYAMTSFhytimvTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15333   231 FHLAIFDF------FTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
39-299 4.66e-08

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 53.31  E-value: 4.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVC-GLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV-FVCTLPFWAYAGIHE-WVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15215     6 IVIFLCaSLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLqTVLVMPWVIATSVPLfWPLDSHLCTALVVLMHLFAFA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPQII-YGNV-FNLDKLIC------GYHDEAI 187
Cdd:cd15215    86 GVNTIVVVSVDRYLAIIHPLSYPTKMTPRR--GYLLIYGTWIVSVLQSTPPLYgWGQAaFDERNALCsviwgsSYSYTIL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 STVvlatqmtLGFFLPLLTMIVCYSVIIKtllhAGGFQKH-RSLKIIFLVMAVFLLTQMPFNLMKFIRSthWEYYAMTSF 266
Cdd:cd15215   164 SVV-------SSFVLPVIIMLACYSMVFR----AARRCYHcKAAKVIFIIIFSYVLSMGPYSFLSVLAV--WVDTQVPQW 230
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1894925283 267 HYTIMVTeaIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15215   231 VISIILW--LFFLQCCIHPYIYGYMHKSIKKEF 261
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
34-299 5.58e-08

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 53.00  E-value: 5.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVF-VCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPF-WAYAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15335     2 LIVLTLALItILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDfLVAVLVMPLsITYIVMDTWTLGYFICEIWLSVDM 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFIVVVKATK-AYNQQAKRmtwGKVTSLLIWVISLLVSLPQIIYGN--VFNLDKLICGYHDEAI 187
Cdd:cd15335    82 TCCTCSILHLCVIALDRYWAITDAIEyARKRTAKR---AGLMILTVWTISIFISIPPLFWRNhhDANIPSQCIIQHDHVI 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 STVVlatqMTLG-FFLPLLTMIVCYSVIiktllHAGGFQKHRSLKIIFLVMAVFLLTQMPFnlmkFIRSTHWEYYAMTSF 266
Cdd:cd15335   159 YTIY----STFGaFYIPLTLILILYYRI-----YHAASRERKAARILGLILGAFILSWLPF----FIKELIVGLSVMTVS 225
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1894925283 267 HYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15335   226 PEVADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
32-302 6.15e-08

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 52.90  E-value: 6.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLvGNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFW-AYAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15295     2 VLLFLMSLLALVIVL-GNALVIIAFVVDKNLRHRSNYFFLNLAISDfFVGAISIPLYiPYTLTNRWDFGRGLCVFWLVID 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKrMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICgyHDEAIST 189
Cdd:cd15295    81 YLLCTASVYNIVLISYDRYQSVSNAVSYRNQQTA-TLRIVTQMVAVWVLAFLVHGPAILVSDSWKTEDGEC--EPEFFSN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 -VVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQK-HRSLKIIflvMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFH 267
Cdd:cd15295   158 wYILAITSVLEFLVPVILVAYFNTQIYWSLWKRLRDRKlAKSLAII---LGTFAICWAPYSLFTIIRAACEKHRGSPWYN 234
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1894925283 268 YTIMvteaIAYLRACLNPVLYAFVSLKFRKNFWKL 302
Cdd:cd15295   235 FAFW----LQWFNSFINPFLYPLCHKRFRKAFLKI 265
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
37-299 6.82e-08

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 53.37  E-value: 6.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCgLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGIH-EWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15958     7 MALIVLLI-VAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMgLLVVPFGATLVVRgRWLYGSFFCELWTSVDVLCVT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVvkaTKAYNQQAkRMTWGKVTSLL--IWVISLLVS-LPQIIYGNVFNLDKLICGYHDEAISTVV 191
Cdd:cd15958    86 ASIETLCVIAIDRYLAI---TSPFRYQS-LLTRARAKGIVctVWAISALVSfLPIMMHWWRDEDDQALKCYEDPGCCDFV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 L-----ATQMTLGFFLPLLTMIVCYSVIIK--------------------TLLHAGG---------FQKHRSLKIIFLVM 237
Cdd:cd15958   162 TnrayaIASSIISFYIPLLIMIFVYLRVYReakkqikkidkcegrfhntlTGLGRKCkrrpsrilaLREQKALKTLGIIM 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1894925283 238 AVFLLTQMPFNLMKFIRSTHWEYYAMTSFhytiMVTEAIAYLRACLNPVLYAfVSLKFRKNF 299
Cdd:cd15958   242 GVFTLCWLPFFLVNVVNVFNRELVPDWLF----VFFNWLGYANSAFNPIIYC-RSPDFRKAF 298
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
46-299 7.24e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 53.06  E-value: 7.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  46 LVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL------VFVCTLPFWAYAGIHEWVFgqvmcKSLLGIYTINFYTSMLI 119
Cdd:cd14972    13 VVENSLVLAAIIKNRRLHKPMYILIANLAAADLlagiafVFTFLSVLLVSLTPSPATW-----LLRKGSLVLSLLASAYS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 120 LTCITVDRFIVVVKAtKAYNqqaKRMTWGKVTSL--LIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAISTVVLATQMT 197
Cdd:cd14972    88 LLAIAVDRYISIVHG-LTYV---NNVTNKRVKVLiaLVWVWSVLLALLPVLGWNCVLCDQESCSPLGPGLPKSYLVLILV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 198 LgFFLPLLTMIVCYSVI----------IKTLLHAGGFQKHR----SLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYY-A 262
Cdd:cd14972   164 F-FFIALVIIVFLYVRIfwclwrhanaIAARQEAAVPAQPStsrkLAKTVVIVLGVFLVCWLPLLILLVLDVLCPSVCdI 242
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1894925283 263 MTSFHYTIMvteaIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14972   243 QAVFYYFLV----LALLNSAINPIIYAFRLKEMRRAV 275
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
41-299 8.16e-08

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 52.91  E-value: 8.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  41 VFVCGLVGNSLVLVIsIFYHK-LQSLTDVFLVNLPLADLVF-VCTLPFWAYAGI-HEWVF-----GQVMCKSLLGIYTIN 112
Cdd:cd15128    10 IFIVGIIGNSTLLRI-IYQNKcMRNGPNALIASLALGDLLYiVIDLPINVYKLLaMDWPFgdqpfGQFLCKLVPFIQKAS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAynQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDklicgYHDEAISTVVL 192
Cdd:cd15128    89 VGITVLNLCALSVDRYRAVASWSRI--QGIGIPMWTAVEIVMIWMLSAVLAVPEAIGFDMVRFN-----YKGVTLRTCLL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 193 ATQMTL-------------GFF--LPLLTMIVCYSVIIKTLLHAGGFQKHRSL-----------KIIFLVMAVFLLTQMP 246
Cdd:cd15128   162 RPETSFmkfyidvkdwwlfGFYfcLPLVCTAIFYTLMTCEMLRKRNGMLRIALnehlkqrrevaKTVFCLVVIFALCWLP 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1894925283 247 FNLMKFIRSTHWEYY-----AMTSFhytIMVTEAI----AYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15128   242 LHLSRILKLTVYDQNdpnrcELLSF---LLVLDYFginlATLNSCINPIALYFVSRKFKNCF 300
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
31-299 8.54e-08

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 53.08  E-value: 8.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  31 KVFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQS-LTDVFLVNLPLAD-LVFVCTLPFWAYAGIHE-WVFGQvMCKSLLG 107
Cdd:cd15320     1 RVLTGCFLSVLILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDlLVAVLVMPWKAVAEIAGfWPFGS-FCNIWVA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 108 IYTINFYTSMLILTCITVDRFIvvvkATKAYNQQAKRMTwGKVTSLLI---WVISLLVSLPQI------------IYGNV 172
Cdd:cd15320    80 FDIMCSTASILNLCVISVDRYW----AISSPFRYERKMT-PKVAFIMIsvaWTLSVLISFIPVqlnwhkakptsfLDLNA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 173 FNLDKLI--CgyhDEAISTVVLATQMTLGFFLPLLTMIVCYSVI----------IKTLLHAGGFQKHRS----------- 229
Cdd:cd15320   155 SLRDLTMdnC---DSSLNRTYAISSSLISFYIPVAIMIVTYTRIyriaqkqirrISALERAAVHAKNCQnstgnrgsgdc 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 230 -----------------LKIIFLVMAVFLLTQMPFNLMK----FIRSTHWEYYAMTSFHYTIMVTeaIAYLRACLNPVLY 288
Cdd:cd15320   232 qqpessfkmsfkretkvLKTLSVIMGVFVCCWLPFFILNcmvpFCKPTSTEPFCISSTTFDVFVW--FGWANSSLNPIIY 309
                         330
                  ....*....|.
gi 1894925283 289 AFvSLKFRKNF 299
Cdd:cd15320   310 AF-NADFRKAF 319
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
40-303 1.21e-07

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 52.56  E-value: 1.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV---FVCTLPFwAYAGIHEWVFGQVMCK------SLLGIyt 110
Cdd:cd15084    19 MVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLvtlFGSSVSF-SNNIVGFFVFGKTMCEfegfmvSLTGI-- 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 infyTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGkvtSLLIWVISLLVSLPQIIYGNVFNLDKL--ICG---YHDE 185
Cdd:cd15084    96 ----VGLWSLAILAFERYLVICKPMGDFRFQQRHAVSG---CAFTWGWSLLWTSPPLFGWSSYVPEGLrtSCGpnwYTGG 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 186 AISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHR----------SLKIIFLVMAvFLLTQMPFNLMKFIRS 255
Cdd:cd15084   169 TNNNSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQQKESettqraekevTRMVIAMVMA-FLICWLPYATFAMVVA 247
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1894925283 256 THWEyyamtsfhytIMVTEAIAYLRA-------CLNPVLYAFVSLKFRKNFWKLV 303
Cdd:cd15084   248 TNKD----------VVIQPTLASLPSyfsktatVYNPIIYVFMNKQFRSCLLELL 292
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
46-299 1.79e-07

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 51.86  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  46 LVGNSLVLVISIFYHKLQSLTDVFLV-NLPLADLV---------FVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd14980    15 LIGNILVIIWHISSKKKKKKVPKLLIiNLAIADFLmgiylliiaIADQYYRGRYAQYSEEWLRSPPCLLACFLVSLSSLM 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMtwgKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGY-------HDEAIS 188
Cdd:cd14980    95 SVLMMLLITLDRYICIVYPFSNKRLSYKSA---KIILILGWLFSIIFAAIPILYSINQPGDNRLYGYssicmpsNVSNPY 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLATQMTLGFFLPLLTMIVCYSVIIKTLlHAGGFQKHRSL----KIIFLVMAVFLLTQMPFNLMKFIRSTHWeyyamt 264
Cdd:cd14980   172 YRGWLIAYLLLTFIAWIIICILYILIFISV-RKSRKSARRSSskrdKRIAIRLALILITDLICWLPYYIVIFSG------ 244
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1894925283 265 SFHYTIMVTEAIAY-------LRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14980   245 LLTSTEIDIHVLQFiailalpLNSAINPYLYTLTTPTFKRDF 286
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
40-242 4.41e-07

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 50.71  E-value: 4.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVI----------SIFYhklqsltdVFLVNLPLADLVFVCTLP---FWAYAGIHEWVFGQVMCKSLL 106
Cdd:cd14981     9 LMFVFGVLGNLLALIVlarsskshkwSVFY--------RLVAGLAITDLLGILLTSpvvLAVYASNFEWDGGQPLCDYFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 107 GIYTINFYTSMLILTCITVDRFIVVVKATkAYNQQAKRMTwGKVTSLLIWVISLLV-SLPQIIYGNVFN--------LDk 177
Cdd:cd14981    81 FMMSFFGLSSLLIVCAMAVERFLAITHPF-FYNSHVKKRR-ARLMLGAVWAFALLIaSLPLLGLGSYVLqypgtwcfLD- 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1894925283 178 LICGYHDEAISTVVLAtqmTLGFFLpLLTMIVCYSVIIKTLLHA--------GGFQKHRSLKIIFLVMAVFLL 242
Cdd:cd14981   158 FYSKNTGDAAYAYLYS---ILGLLI-LLVTLLCNLLVIITLLRMrrrkkrhrRSRRSARRQKRNEIQMVVLLL 226
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
37-299 4.54e-07

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 50.42  E-value: 4.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCgLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWA--YAGIHEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15309     7 LTLLIFVI-VFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVvyLEVVGEWRFSRIHCDIFVTLDVMMCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATkAYNQQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNvfNLDKLICGYHDEAIstvvLAT 194
Cdd:cd15309    86 ASILNLCAISIDRYTAVAMPM-LYNTRYSSKRRVTVMISVVWVLSFAISCPLLFGLN--NTDQNECIIANPAF----VVY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 195 QMTLGFFLPLLTMIVCYsVIIKTLLHaggfQKHRSLKIIFLVMAVFLLTQMPFnLMKFIRSTHWEYYAMTSFHYTIMvte 274
Cdd:cd15309   159 SSIVSFYVPFIVTLLVY-VQIYIVLQ----KEKKATQMLAIVLGVFIICWLPF-FITHILNMHCDCNIPPALYSAFT--- 229
                         250       260
                  ....*....|....*....|....*
gi 1894925283 275 AIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15309   230 WLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
47-299 4.80e-07

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 50.50  E-value: 4.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  47 VGNSLVLVISIFYHKLQSLTDVFLVNLPLADL-VFVCTLPF-WAYAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTCIT 124
Cdd:cd15050    16 ILNLLVLYAVRTERKLHTVGNLYIVSLSVADLiVGAVVMPLnIVYLLESKWILGRPVCLFWLSMDYVASTASIFSLFILC 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 125 VDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVSLPqIIYGNVFN--------LDKLICGYHDEAISTVVLATqm 196
Cdd:cd15050    96 IDRYRSVQQPLKYLKYRTKTR--ASLMISGAWLLSFLWVIP-ILGWHHFArggervvlEDKCETDFHDVTWFKVLTAI-- 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 197 tLGFFLPLLTMIVCYSVIIKTLlhaggFQKHRSLKIIFLVMAVFLLTQMPFnlmkFIRSTHWEYYAMTSFHYTIMVTEAI 276
Cdd:cd15050   171 -LNFYIPSLLMLWFYAKIFKAV-----NRERKAAKQLGFIMAAFILCWIPY----FILFMVIAFCKNCCNENLHMFTIWL 240
                         250       260
                  ....*....|....*....|...
gi 1894925283 277 AYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15050   241 GYINSTLNPFIYPLCNENFKKTF 263
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
40-292 5.03e-07

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 50.57  E-value: 5.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVC--TLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSM 117
Cdd:cd15386     9 AILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfqVLPQLIWEITYRFQGPDLLCRAVKYLQVLSMFAST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 118 LILTCITVDRFIVVVKATKAYNQQakrmtwGKVTSLLI---WVISLLVSLPQIIygnVFNLDKLICG----------YHD 184
Cdd:cd15386    89 YMLIMMTVDRYIAVCHPLRTLQQP------SRQAYLMIgatWLLSCILSLPQVF---IFSLREVDQGsgvldcwadfGFP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 185 EAISTVVLATQMTLgFFLPLLTMIVCYSVI---------------------------------IKTLLHAggfqKHRSLK 231
Cdd:cd15386   160 WGAKAYITWTTLSI-FVLPVAILIVCYSLIcyeicknlkgktqtsrsegggwrtqgmpsrvssVRTISRA----KIRTVK 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1894925283 232 IIFLVMAVFLLTQMPFNLMKFIrsTHWEYYA----MTSFHYTImvTEAIAYLRACLNPVLYAFVS 292
Cdd:cd15386   235 MTFVIVLAYIACWAPFFSVQMW--SVWDENApdedSSDFAFTI--TMLLASLSSCCNPWIYMFFS 295
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
32-299 6.81e-07

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 50.14  E-value: 6.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNsLVLVISIFYHK-LQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGIHE-WVFGQVMCKSLLGI 108
Cdd:cd15317     1 VIIYIVLVLAMLITVSGN-LVVIISISHFKqLHSPTNMLVLSLATADfLLGLCVMPFSMIRTVETcWYFGDLFCKFHTGL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 109 YTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIYGNVfnlDKLICGYHDE--A 186
Cdd:cd15317    80 DLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAW--RFIAIGWLVPGIYTFGLIYTGAN---DEGLEEYSSEisC 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMTLG------FFLPLLTMIVCYSVI----------IKTL-----------LHAGGFQKHRSLKIIFLVMAV 239
Cdd:cd15317   155 VGGCQLLFNKIWVlldfltFFIPCLIMIGLYAKIflvarrqarkIQNMedkfrsseensSKASASRERKAAKTLAIVMGI 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1894925283 240 FLLTQMPFnlmkFIRSTHWEYyamTSFHYTIMVTEAI---AYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15317   235 FLFCWLPY----FIDTIVDEY---SNFITPAIVFDAViwlGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
40-299 6.87e-07

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 50.24  E-value: 6.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVIsIFYHK-LQSLTDVFLVNLPLADLVFVCT-LPFWAYAGI-HEWVF-----GQVMCKSLLGIYTI 111
Cdd:cd15975     9 IIFIVGMVGNATLLRI-IYQNKcMRNGPNALIASLALGDLIYIVIdIPINVYKLLaQKWPFddssfGVFLCKLVPFLQKA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSllIWVISLLVSLPQIIYGNVFNLDklicgYHDEAISTVV 191
Cdd:cd15975    88 SVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIFS--IWVLSFILAIPEAIGFVMVPFE-----YNGEQYRTCM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 L-ATQMTLGFF--------------LPLLTMIVCYSVIIKTLLH--AGGF---------QKHRSLKIIFLVMAVFLLTQM 245
Cdd:cd15975   161 LnATTKFMNFYvdakdwwlfgfyfcVPLACTAIFYTLMTCEMLNrrKGSLrialsehlkQRREVAKTVFCLVVIFALCWF 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 246 PFNLMKFIRSTHWEYY-----AMTSFHYTI-MVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15975   241 PLHLSRILKKTVYNENdprrcELLSFLLVMdYISINLATMNSCINPIALYFVSKKFKNCF 300
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
36-292 7.72e-07

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 49.73  E-value: 7.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWAYAGIHEWVF-GQVMCKSLLGIYTINF 113
Cdd:cd14964     3 IILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLAsLVVLVLFFLLGLTEASSrPQALCYLIYLLWYGAN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIYGNVFNlDKLICGYHDEAISTVVLA 193
Cdd:cd14964    83 LASIWTTLVLTYHRYFALCGPLKYTRLSSPGKT--RVIILGCWGVSLLLSIPPLVGKGAIP-RYNTLTGSCYLICTTIYL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 194 TQ--MTLGFFLPLLTMIVCYSVIIKTLLHAG----------GFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIrstHWEYY 261
Cdd:cd14964   160 TWgfLLVSFLLPLVAFLVIFSRIVLRLRRRVrairsaaslnTDKNLKATKSLLILVITFLLCWLPFSIVFIL---HALVA 236
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1894925283 262 AMTSFHYTIMVTEAIAYLRACLNPVLYAFVS 292
Cdd:cd14964   237 AGQGLNLLSILANLLAVLASTLNPFIYCLGN 267
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
32-299 7.96e-07

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 49.82  E-value: 7.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV--FVCTLPFWAYAGIHEWVFGQVMCKSLLGIY 109
Cdd:cd15981     1 AMFILAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLvgIFCMPTTLVDNLITGWPFDNAMCKMSGLVQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 TINFYTSMLILTCITVDRFIVVVKATkaynQQAKRMTWGKVTSLLIWVISLLVSLPQII---------------YGNVFN 174
Cdd:cd15981    81 GMSVSASVFTLVAIAVERFRCIVHPF----RQKLTLRKAIVTIVIIWVLALIIMCPSAVtltvtreehhfmvddYNNSYP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 175 LDKLICGYHDEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGF----------------QKHRSLKIIFLVMA 238
Cdd:cd15981   157 LYSCWEAWPDTEMRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPirgsqgeeeegrrvskRKIKVINMLIIVAL 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1894925283 239 VFLLTQMP-FNLMKFIRSTHWEYYAMTSFH-YTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15981   237 FFTLSWLPlWTLMLLTDYGHLSEDQLNLVTvYVFPFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
40-292 8.58e-07

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 49.82  E-value: 8.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV--FVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSM 117
Cdd:cd15385     9 VIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVvaFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLGMFAST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 118 LILTCITVDRFIVVVKATKAYNQQAKRmtwGKVTSLLIWVISLLVSLPQIIygnVFNLDKLICGYHD--------EAIST 189
Cdd:cd15385    89 YMLVMMTADRYIAICHPLKTLQQPTKR---SYLMIGSAWALSFILSTPQYF---IFSLSEIENGSGVydcwanfiVPWGI 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTLGFFL-PLLTMIVCYSVI--------------------------------IKTLLHAggfqKHRSLKIIFLV 236
Cdd:cd15385   163 KAYITWITISIFVvPVIILLTCYGFIcyniwrnikcktrrglsdnalknillavcvssVKTISRA----KIRTVKMTFVI 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 237 MAVFLLTQMPFNLMK----FIRSTHWEyyamTSFHYTIMVTEAIAYLRACLNPVLYAFVS 292
Cdd:cd15385   239 VLAYIVCWAPFFTIQmwsvWDQNFPWD----ESENTAVTITALLASLNSCCNPWIYMFFS 294
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
40-299 1.28e-06

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 49.35  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVfVCTL--PFWAYAGIH-EWVFGQVMCK------SLLGIyt 110
Cdd:cd15086     9 FILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLL-VCVLgtPFSFAASTQgRWLIGEHGCRwygfanSLFGI-- 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 infyTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSlliWVISLLVSLPQIIYGNVFNLD--KLICGYHDEAIS 188
Cdd:cd15086    86 ----VSLISLAVLSYERYCTLLRPTEADVSDYRKAWLGVGGS---WLYSLLWTLPPLLGWSSYGPEgpGTTCSVQWTSRS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 189 TVVLATQMTLGFF---LPLLTMIVCYSVIIKTLLHAGGFQK-------HRSLKIIFLVMAVFLLTQMPFNLMKFIrSTHW 258
Cdd:cd15086   159 ANSISYIICLFIFcllLPFLVMVYCYGRLLYAIKQVGKINKstarkreQHVLLMVVTMVICYLLCWLPYGVMALL-ATFG 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1894925283 259 EYYAMTSFhyTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15086   238 KPGLVTPV--ASIVPSILAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
39-299 1.42e-06

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 49.18  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL---VFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTinfYT 115
Cdd:cd14968     8 VLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADIlvgALAIPLAILISLGLPTNFHGCLFMACLVLVLT---QS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSLliWVISLLVSLPQIIYGNVFNLDKLICGYHDEA--ISTVVLA 193
Cdd:cd14968    85 SIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVC--WVLSFLVGLTPMFGWNNGAPLESGCGEGGIQclFEEVIPM 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 194 TQMT-LGFF----LPLLTMIVCYS----VIIKTL-----LHAGGFQKH------RSLKIIFLVMAVFLLTQMPFNLMKFI 253
Cdd:cd14968   163 DYMVyFNFFacvlVPLLIMLVIYLrifrVIRKQLrqiesLLRSRRSRStlqkevKAAKSLAIILFLFALCWLPLHIINCI 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1894925283 254 RSTHWEYYA-MTSFHYTIMVTEAiaylRACLNPVLYAFVSLKFRKNF 299
Cdd:cd14968   243 TLFCPECKVpKILTYIAILLSHA----NSAVNPIVYAYRIRKFRQTF 285
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
33-292 1.52e-06

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 49.00  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFV--CTLPFWAYAGIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15398     2 FLIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVlfCSPFTLTCVLLDQWIFGEVMCHIVPFLQC 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFYTSMLILTCITVDRFiVVVKATKAYNQQAKRmtwGKVTSLLIWVISLLVSLPQIIYGNVFNLDKlicGYHDEAISTV 190
Cdd:cd15398    82 VSVMVSTLMLMSIAIVRY-HMIKHPLSNHLTANH---GYFLLGTVWTLGFTICSPLPVFHKIVDLSE---TFNLESLKNK 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLATQ------MTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHRSLKIIF----LVMAVFLLTQMPFNLMKFIRSTHWEY 260
Cdd:cd15398   155 YLCIEswpsdsYRIAFTISLLFVQYILPLVCLTVSHTSVCRSVKRSRSVFyrltIVILAFAVSWMPLHLFHLVTDFNANL 234
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1894925283 261 YAMTSFHYTIMVTEAIAYLRACLNPVLYAFVS 292
Cdd:cd15398   235 ISNRHFKLVYCICHLLGMLSCCLNPILYGFLN 266
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
37-212 2.53e-06

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 48.32  E-value: 2.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVfVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPFWA-YAGIHEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15957     7 MSLIV-LAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMgLAVVPFGAaHILLKTWTFGNFWCEFWTSIDVLCVT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYNQQAKRMtwGKVTSLLIWVISLLVS-LPQIIYGNVFNLDKLICGYHDEA-----IS 188
Cdd:cd15957    86 ASIETLCVIAVDRYFAITSPFKYQSLLTKNK--ARVIILMVWIVSGLTSfLPIQMHWYRATHQEAINCYAEETccdffTN 163
                         170       180
                  ....*....|....*....|....
gi 1894925283 189 TVVLATQMTLGFFLPLLTMIVCYS 212
Cdd:cd15957   164 QAYAIASSIVSFYVPLVIMVFVYS 187
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
37-299 2.99e-06

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 48.24  E-value: 2.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL---VFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTinf 113
Cdd:cd15070     6 IEILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIavgVLVIPLAIVVSLGVTIHFYSCLFMSCLLVVFT--- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTslLIWVISLLVSLPQI------IYGNVFNLDKLICGYHdeai 187
Cdd:cd15070    83 HASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALG--LCWLVSFLVGLTPMfgwnrkPSLESVNTTPLQCQFT---- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 188 STVVLATQMTLGFF----LPLLTMIVCYSVI---IKTLL--------HAGGF--QKHRSLKIIFLVMAVFLLTQMPFNLM 250
Cdd:cd15070   157 SVMRMDYMVYFSFFtwilIPLVIMCALYVDIfyiIRNKLsqnatgfrETGAFygREFKTAKSLALVLFLFAVCWLPLSII 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1894925283 251 KFIrsthwEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15070   237 NCV-----VYFNPKVPKIALYLGILLSHANSMMNPIVYACKIKKFKETY 280
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
39-304 3.25e-06

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 47.78  E-value: 3.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFyHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSML 118
Cdd:cd15107     8 IIIALVGLAGNAIVLWLLGF-HMHRNAFSVYILNLAGADFLFLCTQIVFSLEIVLQFHSIDIHIPLFLLTVTMFAYLAGL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 119 -ILTCITVDRFIVVVKATkAYNQQAKRMTwGKVTSLLIWVISLLVSLPQ-IIYGNVFN-LDKLICGYHDEAISTVVLATQ 195
Cdd:cd15107    87 sMITAISIERCLSVMWPI-WYHCQRPRHT-SAVICTLLWVLSLLLSLLEgKGCGFLFStYDYYWCWTLDLITTAWLIVLF 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 196 MTL-GFFLPLLTMIVCYSVIIKTLlhaggfqkhRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYYAMTSFHYTiMVTE 274
Cdd:cd15107   165 VVLsGSSLALLVRIFCGSHRIPVT---------RLYVTIALTVLVFLIFGLPFGIYWFLLKWIEEFYIVPCCGFY-EVIL 234
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1894925283 275 AIAYLRACLNPVLYAFV-SLKFRKNFWKLVK 304
Cdd:cd15107   235 FLSCVNSCANPIIYFLVgSIRHHRFQRKTLK 265
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
40-299 4.61e-06

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 47.58  E-value: 4.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIH----------EWVfGQVMCKsLLGIY 109
Cdd:cd15137     9 VVGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVYLLIIASVDLYyrgvyikhdeEWR-SSWLCT-FAGFL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 110 -TINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMtwgKVTSLLIWVISLLVSLPQII---YGNVFNLDKLIC---GY 182
Cdd:cd15137    87 aTLSSEVSVLILTLITLDRFICIVFPFSGRRLGLRRA---IIVLACIWLIGLLLAVLPLLpwdYFGNFYGRSGVClplHI 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 183 HDEAI-----STVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQKHR----SLKIIFLVMAVFlLTQMPFNLMKFi 253
Cdd:cd15137   164 TDERPagweySVFVFLGLNFLAFVFILLSYIAMFISIRRTRKAAASRKSKRdmavAKRFFLIVLTDF-LCWIPIIVIGI- 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1894925283 254 rsthweyyaMTSFHYTIMvTEAIAY-------LRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15137   242 ---------LALSGVPIP-GEVYAWvavfvlpINSALNPILYTLSTPKFRKKL 284
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
46-299 5.04e-06

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 47.24  E-value: 5.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  46 LVGNSLVlVISIFYHK-LQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGI-HEWVFGQVMCKSLLGIYTINFYTSMLILTC 122
Cdd:cd15314    15 VCGNLLV-IISIAHFKqLHTPTNYLILSLAVADlLVGGLVMPPSMVRSVeTCWYFGDLFCKIHSSFDITLCTASILNLCF 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 123 ITVDRFIVVVKATKAYNQQAKRMTWgkVTSLLIWVISLLVSLPQIIygnvFNLDKLICGYHDEA--------ISTVVLAT 194
Cdd:cd15314    94 ISIDRYYAVCQPLLYRSKITVRVVL--VMILISWSVSALVGFGIIF----LELNIKGIYYNHVAceggclvfFSKVSSVV 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 195 QMTLGFFLPLLTMIVCYSVI----------IKTLLHAGGF----QKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSThwey 260
Cdd:cd15314   168 GSVFSFYIPAVIMLCIYLKIflvaqrqarsIQSARTKSGAssskMERKATKTLAIVMGVFLLCWTPFFLCNIIDPF---- 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1894925283 261 yamtsFHYTI--MVTEA---IAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15314   244 -----INYSIppVLIEVlnwLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
38-296 5.12e-06

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 47.45  E-value: 5.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYA--GIHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15167     7 YYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVKIAVdlGIAPWKLKIFHCQVTACLIYINMYL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAYnqQAKRMTWGKVTSLLIWVISLLVSLPQIIYGNVFNLDKLICGYHDEAIST----VV 191
Cdd:cd15167    87 SIIFLGFVSIDRYLQLTHSSKLY--RIQEPGFAKMISAVVWTLVLFIMVPNMAIPIKTIEEKPGVGCADFKTEFgrhwHV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 LATQMTLGFFLPLLTMIVCYS-VIIKTLLHAGGFQKHRSLKI----IFLVMAVFLLTQMPFNLMKfIRSTHWEYYAMTSF 266
Cdd:cd15167   165 LTNFICMAIFLNFSAIILISNfLVIRKLYRNKDSEEYRNARQalvnILLVTAGYVICFVPYHIVR-IPYTLSQSEVITDC 243
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1894925283 267 HYTIMV------TEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15167   244 SLKRSLflakesTLLLAVLNLCFDPILYFHLSKAFR 279
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
46-299 5.80e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 47.37  E-value: 5.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  46 LVGNSLVLV-ISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAY-----AGIHEwvfGQVMCKSLLGIYTINFYTSMLI 119
Cdd:cd15104    14 ITGNLLVIVaLLKLIRKKDTKSNCFLLNLAIADFLVGLAIPGLATdellsDGENT---QKVLCLLRMCFVITSCAASVLS 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 120 LTCITVDRFIVVVKATKaYNQQAKRMTWGKVtSLLIWVISLLV-SLPQIIYGNVFNLDKLICGYHDEAISTVVLaTQMTL 198
Cdd:cd15104    91 LAAIAFDRYLALKQPLR-YKQIMTGKSAGAL-IAGLWLYSGLIgFLPLISPQFQQTSYKGKCSFFAAFHPRVLL-VLSCM 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 199 GFFLPLLTMIVCYSVI----------IKTLLHAGGFQKHRS--------LKIIFLVMAVFLLTQMPFNLMKFIRSThwey 260
Cdd:cd15104   168 VFFPALLLFVFCYCDIlkiarvhsraIYKVEHALARQIHPRrtlsdfkaARTVAVLIGCFLLSWLPFQITGLVQAL---- 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1894925283 261 yaMTSFHYTIMVTEAIAYLRAC---LNPVLYAFVSLKFRKNF 299
Cdd:cd15104   244 --CDECKLYDVLEDYLWLLGLCnslLNPWIYAFWQKEVRRAL 283
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
39-305 1.24e-05

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 46.24  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTdVFLVNLPLADLVFVctlpFWAYAGIHEWVFGQVMCKSLLGIYTINFY---- 114
Cdd:cd15110     8 LIICLLGLVGNGIVLWFLGFRIRRNPFT-VYILHLAIADFTFL----LCIFILSIMYIGPFNFSHSRDYVAMLIFIilfl 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 ----TSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSlpqiiygnvfNLDKLICGYHDEAISTV 190
Cdd:cd15110    83 fgynTGLYLLTAISVERCLSVLYPIWYRCHRPKHQS--AIVCGLLWALSVLMT----------SLEYLMCIDEGFHVRNE 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 191 VLATQMTLGF--FLPLLTMIVCYSVIIKTLLHAGgFQKHRSLK---IIFLVMAVFLLTQMPFNLMKFIRSTHWEYYaMTS 265
Cdd:cd15110   151 CRAVLIFIGIltFLVFTPLMLISSLILFIKVRCN-SQRRHPGKlyiIIMLTVIFFLIFAMPMRVLLLLNYLHHSSF-LFS 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 266 FHYTIMvteaIAYLRACLNPVLYAFVSLKFRKNFWKLVKD 305
Cdd:cd15110   229 NPVPFL----LSTVNSSINPIVYFLVGSLRRKRIKKSLKV 264
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
38-249 1.80e-05

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 45.50  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  38 YLVVFVCGLVGNslVLVISIFYHKLQSLTD---VFLVNLPLADLVFVCTLPFWAYAGI-HEWVFGQVMCKSLLGIYTINF 113
Cdd:cd14983     7 YVLTILLGLPSN--LLALYAFVNRARLRLTpnvIYMINLCLSDLVFILSLPIKIVEALsSAWTLPAVLCPLYNLAHFSTL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 114 YTSMLILTCITVDRFIVVvkATKAYNQQAKRMTWGKVTSLLIWVIS-------LLVSLPQIIYGNVFNLDKLICGYH--D 184
Cdd:cd14983    85 YASTCFLTAISAGRYLGV--AFPIKYQLYKKPLYSCLVCVAIWALVifhvtlvFILETSGGTLDINTPVGNSSTCYEnfT 162
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1894925283 185 EAISTVVLATQMTLG---FFLPLLTMIVCY----SVIIKTLLHAGgfQKHRSLKIIFLVMAVFLLTQMPFNL 249
Cdd:cd14983   163 PEQLALLAPVRLELSlvlFFLPLAITAFCYvrciRILVRSRLHER--RKRRAVRVAVSTLLTFVVCFGPYNI 232
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
40-297 2.74e-05

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 45.21  E-value: 2.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVF-VCTLPF-WAYAGIHEWVFGQVMCKSLLGIYTINFYTSM 117
Cdd:cd15008     8 VLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLsVASAPFvLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQI 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 118 LILTCITVDRF--IVVVKATKAYNQQAKRMTwgkvtsLLIWVI-SLLVSLPQIIYGNVF--NLDKLICGYHDEAISTVVl 192
Cdd:cd15008    88 YVLLSICVDRFytIVYPLSFKVSREKAKKMI------AASWLFdAAFVSPALFFYGSNWgpHCNFFLPDSWDGAAYAII- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 193 atQMTLGFFLPLLTMIVCYSVIIKTL--LHAGGFQKHRSLKII----------FLVM-AVFLLTQMPFNLMKFIRSTHWE 259
Cdd:cd15008   161 --HLLVGFLVPSILIILFYQKVIKYIwrIGTDGRTVRRTMNIVprtkvktikmFLMLnSMFLLSWLPFYVVQLWHPRESD 238
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1894925283 260 YYAMTSFHYTIMVteaIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15008   239 YRQSSLVFLAVTW---ISFSSSASKPTLYSVYNANFRR 273
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
36-299 6.00e-05

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 44.18  E-value: 6.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVCGLVGNSLVLVISIFYHKLQS-LTDVFLVNLPLADL-VFVCTLPFWAYAGIH-EWVFGqVMCKSLLGIYTIN 112
Cdd:cd15319     5 CLLSLLILWTLLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLfVALLVMPWKAVAEVAgYWPFG-AFCDVWVAFDIMC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTslLIWVISLLVSLPQI------------IYGNVFNLDKLIC 180
Cdd:cd15319    84 STASILNLCVISVDRYWAISSPFRYERKMTQRVALVMIS--VAWTLSVLISFIPVqlnwhkdsgddwVGLHNSSISRQVE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 181 GYHDEAISTVVLATQMTLGFFLPLLTMIVCYSVIIK--------------------------------TLLHAGGFQKHR 228
Cdd:cd15319   162 ENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRiaqiqirrissleraaehaqscrsnridchhhTSLRTSIKKETK 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 229 SLKIIFLVMAVFLLTQMPF---NLMKFIRSTHWEY-------YAMTSFHYTIMvteaIAYLRACLNPVLYAFvSLKFRKN 298
Cdd:cd15319   242 VLKTLSVIMGVFVCCWLPFfilNCMVPFCDRPPADpdaglpcVSETTFDVFVW----FGWANSSLNPIIYAF-NADFRKV 316

                  .
gi 1894925283 299 F 299
Cdd:cd15319   317 F 317
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
36-168 7.67e-05

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 43.69  E-value: 7.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  36 CMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL--VFVCtLPFWAYAGI-HEWVFGQVMCKSLLGIYTIN 112
Cdd:cd15127     5 CLSVVIFGIGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFliIFFC-LPLVIFHELtKKWLLGDFSCKIVPYIEVAS 83
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKaTKAYNQQAKRMTWGKVTSLLIWVISLLVSLPQII 168
Cdd:cd15127    84 LGVTTFTLCALCIDRFRAATN-VQMYYEMIENCTSTTAKLAVIWVGALLLALPEVV 138
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
32-299 8.53e-05

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 43.63  E-value: 8.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  32 VFLPCMYLVVFVCGLVGNSLVL-VISIFYHK---LQSLTDvFLVNLPLAD-LVFVCTLPFWAYAGIHE---WVFGQVMCK 103
Cdd:cd15135     1 ITLTLLYSLILVAGILGNSATIkVTQVLQKKgylQKSVTD-HMVSLACSDlLVLLLGMPVELYSAIWDpfaTPSGNIACK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 104 SLLGIYTINFYTSMLILTCITVDRFIVVVKATKAynqqaKRMTWGKVTSLL--IWVISLLVSLPQII------YGNVFNL 175
Cdd:cd15135    80 IYNFLFEACSYATILNVATLSFERYIAICHPFKY-----KALSGSRVRLLIcfVWLTSALVALPLLFamgtedPLEAFPS 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 176 DKLICGYHDEAISTVVLATQMT-----------LGFFLPLLTM----IVCYSVIIKTLLHAGG-------------FQKH 227
Cdd:cd15135   155 YRGTRHHCQDQKSNLTICTSLSskwtvfqasifSAFVLYLLVLasvaFMCRRMMRALMGSKKGavavkgpggsvqlLRKH 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 228 RSLK--------IIFLVMAVFLLT--QMPFN---LMKFIRSTH-WEYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSL 293
Cdd:cd15135   235 ESAEgktarkqtILFLGLIVGTLAvcWMPNQirrIMAAAKPKDdWTRSYFRAYIILLPIADTFFYLSSVLNPLLYNLSSQ 314

                  ....*.
gi 1894925283 294 KFRKNF 299
Cdd:cd15135   315 QFRSVF 320
7tmA_MrgprF cd15109
mas-related G protein-coupled receptor subtype F, member of the class A family of ...
37-301 1.18e-04

mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320237  Cd Length: 274  Bit Score: 42.97  E-value: 1.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFYHKLQSLTdVFLVNLPLADLVFVCTLPFWAYAGIHEWV-----FGQVMCKsLLGIYTi 111
Cdd:cd15109     6 IFLLLCLCGLVGNGLVLWFFGFSIKRNPFS-IYFLHLASADVGYLFSKAVFSILNTGGFLgtfadYIRSVSR-ILGLCT- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 112 nFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSlpqiiygNVFNLDKLICGYhdEAISTVV 191
Cdd:cd15109    83 -FLTGVSLLPAISIERCVSVIFPTWYWRRRPKRLS--AVVCALLWMLSLLVT-------CIHNYFCVFLGR--EAPGAAC 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 192 LATQMTLGFFLPL----LTMIVCYSVIIKTLLHAGGFQKHRSLK-IIFLVMAVFLLTQMPFNLMKFIrstHWEYYAMTSF 266
Cdd:cd15109   151 RHMDIFLGILLFLlfcpLMVLPCLALILHVECRARRRQRSAKLNhVILAMVSVFLVSSIYLGIDWFL---FWVFQIPAPF 227
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1894925283 267 HYtiMVTEAIAYLRACLNPVLYAFVSLKFRKNFWK 301
Cdd:cd15109   228 PE--YVTDLCICINSSAKPIVYFLAGRDKSQRLWE 260
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
39-218 2.25e-04

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 42.45  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV--FVCtLP--FWAYAGIHEWVFGQVMCKSLLGIYTINFY 114
Cdd:cd15212     8 LAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLtaLLC-LPfaFLTLFSRPGWLFGDRLCLANGFFNACFGI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAynqqakRMTWGKVTSLL--IWVISLLVSLPQIIYGNVFNLDKLICGYH--------D 184
Cdd:cd15212    87 VSTLTMTLISFDRYYAIVRQPQG------KIGRRRALQLLaaAWLTALGFSLPWYLLASAPEYYEKLGFYHclyvlhsgP 160
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1894925283 185 EAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTL 218
Cdd:cd15212   161 SRLGAAYSSVLIVLCYLLPFALMCFCHYNICKTV 194
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
40-166 2.42e-04

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 42.49  E-value: 2.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPF----WAYAGiHEWVFGQVMCKSLLGIYTINFYT 115
Cdd:cd15198     9 VILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALsqiiWELLG-DRWMAGDVACRLLKLLQASARGA 87
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1894925283 116 SMLILTCITVDRFIVVVKATKAyNQQAKRMTwgkvtsLLIWVISLLVSLPQ 166
Cdd:cd15198    88 SANLVVLLALDRHQAIRAPLGQ-PLRAWKLA------ALGWLLALLLALPQ 131
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
48-297 3.13e-04

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 41.77  E-value: 3.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  48 GNSLVLVISIFYHKLQSLTDVFLVNLPLAD-LVFVCTLPFWAYAGIHE-WVFGQVMCKSLLGIYTINFYTSMLILTCITV 125
Cdd:cd15316    17 GNLLVMISILHFKQLHSPTNFLIASLACADfLVGVTVMPFSTVRSVEScWYFGESFCTFHTCCDVSFCYASLFHLCFISV 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 126 DRFIVV----VKATKAynqqakRMTWGKVTSLLIWVISLLVSLpQIIYGNVFN------LDKLICGYHDEAISTVVLATQ 195
Cdd:cd15316    97 DRYIAVtdplVYPTKF------TVSVSGICISVSWIFSLTYSF-SVFYTGVNDdgleelVNALNCVGGCQIILNQNWVLV 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 196 MTLGFFLPLLTMIVCYSVIIKTLLHAG---------------------GFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIR 254
Cdd:cd15316   170 DFLLFFIPTFAMIILYGKIFLVAKQQArkiemtsskaesssesykdrvARRERKAAKTLGITVIAFLVSWLPYLIDVLID 249
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1894925283 255 SthweYYAMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFRK 297
Cdd:cd15316   250 A----FMNFITPPYIYEICCWCAYYNSAMNPLIYALFYPWFRK 288
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
33-297 5.01e-04

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 41.32  E-value: 5.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAY-AGIHEWVF-GQVMCksLLGIYT 110
Cdd:cd15082    15 VLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFlTNARGYFFlGVWAC--VLEGFA 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 INFY--TSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGkvtSLLIWVISLLVSLPQIIYGNVFNLDKL--ICG---YH 183
Cdd:cd15082    93 VTFFgiVALWSLAVLAFERFFVICRPLGNIRLQGKHAALG---LLFVWTFSFIWTIPPVLGWSSYTVSKIgtTCEpnwYS 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 184 DEAISTVVLATQMTLGFFLPLLTMIVCYSVIIKTLLHAGGFQK--------HRSLKIIFLVMAV-FLLTQMPFNLMKFIR 254
Cdd:cd15082   170 GNMHDHTYIITFFTTCFILPLGVIFVSYGKLLQKLRKVSNTQGrlgnarkpERQVTRMVVVMIVaFMVCWTPYAAFSILV 249
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1894925283 255 STHweyyamTSFHYTIMVTEAIAYLR---ACLNPVLYAFVSLKFRK 297
Cdd:cd15082   250 TAH------PTIHLDPRLAAIPAFFSktaAVYNPIIYVFMNKQFRK 289
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
33-239 8.58e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 40.70  E-value: 8.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVC-GLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV--FVCtLPFWAYAGIH--EWVFGQVMCKSLLG 107
Cdd:cd15217     1 YVKLVLLGLIICvSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIrsAVC-FPFVLVSIRNgsAWTYSVLSCKIVAF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 108 IYTINFYTSMLILTCITVDRFIVVVKatkaYNQQAKRMTWGKVTSL--LIWVISLLVSLPQII----YGNVFNLDKLICG 181
Cdd:cd15217    80 MAVLFCFHAAFMLFCISVTRYMAIAH----HRFYSKRMTFWTCIAVicMVWTLSVAMAFPPVFdvgtYKFIREEDQCIFE 155
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1894925283 182 YHdeaistvVLATQMTLGFFLPLLTMIVC-YSVIIKTLLHAggfQKHRSLKIIFLVMAV 239
Cdd:cd15217   156 HR-------YFKANDTLGFMLMLAVLIVAtHIVYGKLLLFE---YRHRKMKPVQMVPAI 204
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
40-296 1.29e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 40.15  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  40 VVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADL---VFVCTLPFWAYAGIHeWVFGQVMCksLLGIYTINFY-- 114
Cdd:cd15075     9 VFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLgttVFGGLLSVVTNAVGY-FNLGRVGC--VLEGFAVAFFgi 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 115 TSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSlliWVISLLVSLPQIIYGNVFNLDKLI--CG---YHDEAIST 189
Cdd:cd15075    86 AALCTVAVIAVDRLFVVCKPLGTLTFQTRHALAGIASS---WLWSLIWNTPPLFGWGSYQLEGVMtsCApdwYSRDPVNV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 190 VVLATQMTLGFFLPLLTMIVCYSVIIKTL--------LHAGGFQK--HRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWE 259
Cdd:cd15075   163 SYILCYFSFCFAIPFAIILVSYGYLLWTLrqvaklgvAEGGSTAKaeVQVARMVVVMVMAFLLCWLPYAAFALTVVSKPD 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1894925283 260 YYamtsfhYTIMVTEAIAYL---RACLNPVLYAFVSLKFR 296
Cdd:cd15075   243 VY------INPLIATVPMYLaksSTVYNPIIYIFMNKQFR 276
PHA03234 PHA03234
DNA packaging protein UL33; Provisional
51-305 1.60e-03

DNA packaging protein UL33; Provisional


Pssm-ID: 177562 [Multi-domain]  Cd Length: 338  Bit Score: 39.92  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  51 LVLVISIFYHKL--QSLTDVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTCITVDRF 128
Cdd:PHA03234   52 IVICTLIIYHKVakHNATSFYLITLFASDFLHMLCVFFLTLNREALFNFNQAFCQCVLFIYHASCSYSICMLAIIATIRY 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 129 IVVVKATKaynQQAKRMTWGKVTSLLIwVISLLVSLPQIIYGNVfNLDKLICGYHDEAIST-----VVLATQMTLGFFLP 203
Cdd:PHA03234  132 KTLHRRKK---NDKKNNHIGRNIGILF-LASAMCAIPAALFVKT-EGKKGNYGKCNIHISSkkaydLFIAIKIVFCFIWG 206
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 204 LL-TMIVCY-SVIIKTLLHAGGFQKH-RSLKIIFLVMAVFLLTQMPfNLMKFIRSTHWEYYAMTSFHYTI------MVTE 274
Cdd:PHA03234  207 IFpTMIFSFfYVIFCKALHALTEKKHkKTLFFIRILILSFLCIQIP-NIAILICEIAFLYIANNSCFGLAqreilqIIIR 285
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1894925283 275 AIAYLRACLNPVLYAFVSLKFRKNFWKLVKD 305
Cdd:PHA03234  286 LMPEIHCFSNPLVYAFTGGDFRLRFTACFQD 316
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
33-299 1.67e-03

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 39.51  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAGIH----------EWVFGqVMC 102
Cdd:cd15136     2 WLRIGVWFVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAIVDAKtlgeyynyaiDWQTG-AGC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 103 K---------SLLGIYTinfytsmliLTCITVDRFIVVVKATKaYNqqaKRMTWGKVTSLLI--WVISLLVSLPQIIygN 171
Cdd:cd15136    81 KtagflavfsSELSVFT---------LTVITLERWYAITHAMH-LN---KRLSLRQAAIIMLggWIFALIMALLPLV--G 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 172 VFNLDKL-ICGYHD--EAISTVVLATQMTLGfFLPLLTMIVCYSVIIKTlLHAGGFQKHRSLKIIFLVMAVFLLTQMpfn 248
Cdd:cd15136   146 VSSYSKTsICLPFEteTPVSKAYVIFLLLFN-GLAFLIICGCYIKIYLS-VRGSGRAANSNDTRIAKRMALLVFTDF--- 220
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1894925283 249 lmkfirsTHWEYYAMTSF-----HYTIMVTEA------IAYLRACLNPVLYAFVSLKFRKNF 299
Cdd:cd15136   221 -------LCWAPIAFFGLtaafgLPLISVSNAkillvfFYPLNSCANPFLYAIFTKQFRRDC 275
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
34-215 1.83e-03

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 39.39  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  34 LPCMYLVVFVCGLVGNSLVLVISIFYHKLqSLTDVFLVNLPLADLVFVCTLPF-WAYAGIHEWVFGQVMCKSLLGIYTIN 112
Cdd:cd14994     4 LIFLYSVVLIGGVIGVILMSFLLVKMNTR-SVTTTAVINLIVVHSLFLLTVPFrIYYYASKTWKFGMPLCKMVSAMIHIH 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 113 FYTSMLILTCITVDRFIVVVKATKayNQQAKRMTWGKVTSLLIWVISLLVSLPQII--YGNVFNLDKLIC-GYHDE-AIS 188
Cdd:cd14994    83 MHLTFLFYVIILVIRYLIFFQRKD--KMEFYRKLHAVAASAVVWVLVLLIVVPVFVkeYGSSSSYNSDQCfKFHKElEVH 160
                         170       180
                  ....*....|....*....|....*..
gi 1894925283 189 TVVLATQMTLGFFLPLLTMIVCYSVII 215
Cdd:cd14994   161 YVKVLNYIIICIVLIVTLALLGFQVFI 187
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
47-170 2.19e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 39.40  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  47 VGNSLVLVISIFYHKLQSLTDVFLVNLPLADLV--FVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSMLILTCIT 124
Cdd:cd15054    16 AGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMvgLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASILNLCVIS 95
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1894925283 125 VDRFIVVVKATkaynQQAKRMTWGKVTSLLI--WVISLLVSLPQIIYG 170
Cdd:cd15054    96 LDRYLLIISPL----RYKLRMTPPRALALILaaWTLAALASFLPIELG 139
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
95-253 2.59e-03

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 38.78  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  95 WVFGQVMCKSLLGIYTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLPQIIY--GNV 172
Cdd:cd15328    67 WQLGRSLCQVWISFDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRIS--NVMIALTWALSAVISLAPLLFgwGET 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 173 FNLDKLICGYHDEAISTVVlatqMTLG-FFLPLLTMIVCYSVIIKtllhaGGFQKHRSLKIIFLVMAVFLLTQMPFNLMK 251
Cdd:cd15328   145 YSEDSEECQVSQEPSYTVF----STFGaFYLPLCVVLFVYWKIYK-----AAQKEKRAALMVGILIGVFVLCWIPFFLTE 215

                  ..
gi 1894925283 252 FI 253
Cdd:cd15328   216 LI 217
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
41-165 2.94e-03

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 39.03  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  41 VFVCGLVGNSLVLVISIFYHKLQSLTDVFLVNLPLADLVFvCTL---PFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSM 117
Cdd:cd15076    10 VFIVGTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGFIF-CIFsvfPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTG 88
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1894925283 118 LILTCITVDRFIVVVKATKAYNQQAKRMTwgkVTSLLIWVISLLVSLP 165
Cdd:cd15076    89 WSLAFLAFERYIVICKPFGNFRFGSKHAL---GAVVATWIIGIGVSLP 133
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
39-298 7.41e-03

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 37.42  E-value: 7.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  39 LVVFVCGLVGNSLVLVISIFYHKLQSLTdVFLVNLPLADLVFVCTLPFWAYAGIHEWVFGQVMCKSLLGIYTINFYTSML 118
Cdd:cd15106     8 CIISLVGLTGNAVVLWLLGFRMRRNAFS-VYILNLAAADFLFLCCHIIDSLLRLINIFHIISIPKILTNVMTFPYFAGLS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 119 ILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLpqiiygnvfnLDKLICGYHDEAISTVVLAT-QMT 197
Cdd:cd15106    87 MLSAISTERCLSVLWPIWYRCHRPRHLS--AVVCVLLWALSLLLSI----------LEWKFCGFLFSGADSHWCQTfDFI 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 198 LGFFLPLLTMIVCYS---VIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRS---THWEYYamtsFHYTIM 271
Cdd:cd15106   155 TTAWLIFLFVVLCGSslaLLVRILCGSRKMPLTRLYVTILLTVLVFLLCGLPFGIQWFLLLwihIDLEVL----FCHVYL 230
                         250       260
                  ....*....|....*....|....*...
gi 1894925283 272 VTEAIAYLRACLNPVLYAFV-SLKFRKN 298
Cdd:cd15106   231 VSVVLSCLNSSANPIIYFFVgSFRQRQN 258
7tmA_MrgprA cd15105
mas-related G protein-coupled receptor subtype A, member of the class A family of ...
37-291 7.91e-03

mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320233  Cd Length: 276  Bit Score: 37.42  E-value: 7.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  37 MYLVVFVCGLVGNSLVLVISIFyHKLQSLTDVFLVNLPLADLVFVCT---------LPFWAYAGIHEWVFGQVMcksllg 107
Cdd:cd15105     6 MIIIFGLVGLTGNAIVFWLLGF-RLHRNAFSVYILNLALADFLFLLChiidstlllLKVFYPNIIFLPCFYTIM------ 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 108 iyTINFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTwgKVTSLLIWVISLLVSLpqiiygnvfnLDKLICGYHDEA- 186
Cdd:cd15105    79 --MVLYITGLSMLSAISTERCLSVLCPIWYRCRRPEHTS--TVMCAVIWVLSLLICI----------LNRYFCGFLDTKy 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 -ISTVVLATQMTLGFFLPLLTMIVCYS---VIIKTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSthWEYYA 262
Cdd:cd15105   145 eNDSVCLASNFFTAAYLMFLFVVLCLSslaLLARLFCGAGQMKLTRLYVTIMLTVLVFLLCGLPFGIYWFLLF--WIKDD 222
                         250       260       270
                  ....*....|....*....|....*....|
gi 1894925283 263 MTSFHYTI-MVTEAIAYLRACLNPVLYAFV 291
Cdd:cd15105   223 FHVLDYGLyLASVVLTAVNSCANPIIYFFV 252
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
33-296 9.64e-03

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 37.18  E-value: 9.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283  33 FLPCMYLVVFVC-GLVGNSL-VLVISIFYHKLQSLTDVFLVNLPLADLVFVCTLPFWAYAgIHEWVFGQVMCKSLLGIYT 110
Cdd:cd15919     1 FVPVIYYSLLLClGLPANILtVIILSQLVARRQKSSYNYLLALAAADILVLFFIVFVDFL-LEDFILNKQMPQVLDKIIE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 111 I----NFYTSMLILTCITVDRFIVVVKATKAYNQQAKRMTWGKVTSllIWVISLLVSLPQIIYGNVFNLDklicgYHDEA 186
Cdd:cd15919    80 VlefsSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVS--VYITCFLTSIPYYWWPNIWIED-----YTSTS 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894925283 187 ISTVVLATQMTLGFFLPLLTMIVCYSVII-----KTLLHAGGFQKHRSLKIIFLVMAVFLLTQMPFNLMKFIRSTHWEYY 261
Cdd:cd15919   153 MHHVLIWIHCFTVYLVPCSIFFVLNSIIVyklrrKSNFRLRGYSTGKTTAILFTITSIFAILWAPRIIMILYHLYVSPIN 232
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1894925283 262 AMTSFHYTIMVTEAIAYLRACLNPVLYAFVSLKFR 296
Cdd:cd15919   233 NSWLVHIVSDIANMLALLNTAINFFLYCFISKRFR 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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