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Conserved domains on  [gi|1894805377|ref|NP_001373334|]
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transmembrane protein 42a precursor [Danio rerio]

Protein Classification

DMT family transporter( domain architecture ID 581036)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Gene Ontology:  GO:0055085|GO:0005215|GO:0005886
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EamA super family cl23754
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 56-136 6.03e-03

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


The actual alignment was detected with superfamily member pfam00892:

Pssm-ID: 474045  Cd Length: 136  Bit Score: 34.86  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894805377  56 DWLHIPLRLLCGGLlftCNAVMWTFFSKALRHSSSSARATVTTTASnfISSAFLGHVIFGETHATLWWVGIILTLTGLFV 135
Cdd:pfam00892  59 PLKSWLALLYLGVL---GTFLGFLLYFYGLKYVSASNASVITSLSP--VFTLILSVLLLGEKLTLKQLLGIVLILLGVLL 133


                  .
gi 1894805377 136 L 136
Cdd:pfam00892 134 I 134
 
Name Accession Description Interval E-value
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 56-136 6.03e-03

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 34.86  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894805377  56 DWLHIPLRLLCGGLlftCNAVMWTFFSKALRHSSSSARATVTTTASnfISSAFLGHVIFGETHATLWWVGIILTLTGLFV 135
Cdd:pfam00892  59 PLKSWLALLYLGVL---GTFLGFLLYFYGLKYVSASNASVITSLSP--VFTLILSVLLLGEKLTLKQLLGIVLILLGVLL 133


                  .
gi 1894805377 136 L 136
Cdd:pfam00892 134 I 134
 
Name Accession Description Interval E-value
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 56-136 6.03e-03

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 34.86  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1894805377  56 DWLHIPLRLLCGGLlftCNAVMWTFFSKALRHSSSSARATVTTTASnfISSAFLGHVIFGETHATLWWVGIILTLTGLFV 135
Cdd:pfam00892  59 PLKSWLALLYLGVL---GTFLGFLLYFYGLKYVSASNASVITSLSP--VFTLILSVLLLGEKLTLKQLLGIVLILLGVLL 133


                  .
gi 1894805377 136 L 136
Cdd:pfam00892 134 I 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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