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Conserved domains on  [gi|1883538153|ref|NP_001372176|]
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vomeronasal 2, receptor, 122 isoform 4 precursor [Mus musculus]

Protein Classification

vomeronasal type-2 receptor( domain architecture ID 11570779)

vomeronasal type-2 receptor is a G-protein coupled receptor (GPCR) that is involved in detecting protein pheromones for social and sexual cues between the same species; GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

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List of domain hits

Name Accession Description Interval E-value
PBP1_pheromone_receptor cd06365
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within ...
46-500 3.85e-178

Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.


:

Pssm-ID: 380588 [Multi-domain]  Cd Length: 464  Bit Score: 521.05  E-value: 3.85e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  46 CHFYLWKTDEPIEDSF---YNYDLSFRIAGSEYELLLVMFFATDEINKNPYLLPNMSLMFSIIGGNCHDLLRSLDQEYAQ 122
Cdd:cd06365     4 GVFPIHTFSEGKKKDFkepPSPLLCFRFSIKYYQHLLAFLFAIEEINKNPDLLPNITLGFHIYDSCSSERLALESSLSIL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 123 IDGHMNFVNYFCYLDDSCATGLTGPSWKTSLKLA---MHSSMPLVFFGPFNPNLRDHDRLPHVHQVAPKDTHLSHGMVSL 199
Cdd:cd06365    84 SGNSEPIPNYSCREQRKLVAFIGDLSSSTSVAMArilGLYKYPQISYGAFDPLLSDKVQFPSFYRTVPSDTSQSLAIVQL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 200 MFHFRWTWIGLVISDDDQGIQFLSDLREESQRHGICLAFVNMIPENMQiyMTRATIYDTQIMTSSAKVVIIYGDMNSTLE 279
Cdd:cd06365   164 LKHFGWTWVGLIISDDDYGEQFSQDLKKEMEKNGICVAFVEKIPTNSS--LKRIIKYINQIIKSSANVIIIYGDTDSLLE 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 280 ASFRRWEELGARRIWITTTQWDVITNKKDFTLNLFHGTITFAHHKDEIPKFRNFMQTKKTAKYLVDISHTILEWNYFNCS 359
Cdd:cd06365   242 LLFRLWEQLVTGKVWITTSQWDISTLPFEFYLNLFNGTLGFSQHSGEIPGFKEFLQSVHPSKYPEDIFLKTLWESYFNCK 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 360 ISKNSSKMGHF-TFNNTLQWTALHNYDMALSDEGYNLYNAVYAVAHTYHEYILQQVESQKKAKPKRYFTACQQVSSLMKT 438
Cdd:cd06365   322 WPDQNCKSLQNcCGNESLETLDVHSFDMTMSRLSYNVYNAVYAVAHALHEMLLCQPKTGPGNCSDRRNFQPWQLHHYLKK 401
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1883538153 439 RVFMNPVGELVNMKHRENQCTEYDIFIIWNFPQGLGLKVKVGSYLPCFPKSQQLHIADDL-EW 500
Cdd:cd06365   402 VQFTNPAGDEVNFDEKGDLPTKYDILNWQIFPNGTGTKVKVGTFDPSAPSGQQLIINDSMiEW 464
7tmC_V2R_pheromone cd15283
vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G ...
581-831 4.74e-150

vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 pheromone receptors (V2Rs). Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are coexpressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones.


:

Pssm-ID: 320410 [Multi-domain]  Cd Length: 252  Bit Score: 440.56  E-value: 4.74e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 581 PLGMALGCMALSFSAITILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTV 660
Cdd:cd15283     1 PLGIALTVLSLLGSVLTAAVLVVFIKHRDTPIVKANNSELSYLLLLSLKLCFLCSLLFIGQPSTWTCMLRQTAFGISFVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 661 SVSTVLAKTITVVMAFKLTTPGRRMRGMMMTGAPKLVIPICTLIQLVLCGIWLVTSPPFIDRDIQSEHGKIVILCNKGSV 740
Cdd:cd15283    81 CISCILAKTIVVVAAFKATRPGSNIMKWFGPGQQRAIIFICTLVQVVICAIWLATSPPFPDKNMHSEHGKIILECNEGSV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 741 VAFHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAGLLM 820
Cdd:cd15283   161 VAFYCVLGYIGLLALVSFLLAFLARKLPDNFNEAKFITFSMLVFCAVWVAFVPAYISSPGKYMVAVEIFAILASSAGLLG 240
                         250
                  ....*....|.
gi 1883538153 821 CIFVPKCYVIL 831
Cdd:cd15283   241 CIFAPKCYIIL 251
NCD3G pfam07562
Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several ...
508-561 3.11e-19

Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the pfam00003 in several receptor proteins.


:

Pssm-ID: 462210  Cd Length: 53  Bit Score: 81.92  E-value: 3.11e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1883538153 508 PSSVCSVACTAGFRKIHQKETADCCFDCVQCLENEVSNeTDMEQCVRCPDNKYA 561
Cdd:pfam07562   1 PSSVCSESCPPGQRKSQQGGAPVCCWDCVPCPEGEISN-TDSDTCKKCPEGQWP 53
 
Name Accession Description Interval E-value
PBP1_pheromone_receptor cd06365
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within ...
46-500 3.85e-178

Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.


Pssm-ID: 380588 [Multi-domain]  Cd Length: 464  Bit Score: 521.05  E-value: 3.85e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  46 CHFYLWKTDEPIEDSF---YNYDLSFRIAGSEYELLLVMFFATDEINKNPYLLPNMSLMFSIIGGNCHDLLRSLDQEYAQ 122
Cdd:cd06365     4 GVFPIHTFSEGKKKDFkepPSPLLCFRFSIKYYQHLLAFLFAIEEINKNPDLLPNITLGFHIYDSCSSERLALESSLSIL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 123 IDGHMNFVNYFCYLDDSCATGLTGPSWKTSLKLA---MHSSMPLVFFGPFNPNLRDHDRLPHVHQVAPKDTHLSHGMVSL 199
Cdd:cd06365    84 SGNSEPIPNYSCREQRKLVAFIGDLSSSTSVAMArilGLYKYPQISYGAFDPLLSDKVQFPSFYRTVPSDTSQSLAIVQL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 200 MFHFRWTWIGLVISDDDQGIQFLSDLREESQRHGICLAFVNMIPENMQiyMTRATIYDTQIMTSSAKVVIIYGDMNSTLE 279
Cdd:cd06365   164 LKHFGWTWVGLIISDDDYGEQFSQDLKKEMEKNGICVAFVEKIPTNSS--LKRIIKYINQIIKSSANVIIIYGDTDSLLE 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 280 ASFRRWEELGARRIWITTTQWDVITNKKDFTLNLFHGTITFAHHKDEIPKFRNFMQTKKTAKYLVDISHTILEWNYFNCS 359
Cdd:cd06365   242 LLFRLWEQLVTGKVWITTSQWDISTLPFEFYLNLFNGTLGFSQHSGEIPGFKEFLQSVHPSKYPEDIFLKTLWESYFNCK 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 360 ISKNSSKMGHF-TFNNTLQWTALHNYDMALSDEGYNLYNAVYAVAHTYHEYILQQVESQKKAKPKRYFTACQQVSSLMKT 438
Cdd:cd06365   322 WPDQNCKSLQNcCGNESLETLDVHSFDMTMSRLSYNVYNAVYAVAHALHEMLLCQPKTGPGNCSDRRNFQPWQLHHYLKK 401
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1883538153 439 RVFMNPVGELVNMKHRENQCTEYDIFIIWNFPQGLGLKVKVGSYLPCFPKSQQLHIADDL-EW 500
Cdd:cd06365   402 VQFTNPAGDEVNFDEKGDLPTKYDILNWQIFPNGTGTKVKVGTFDPSAPSGQQLIINDSMiEW 464
7tmC_V2R_pheromone cd15283
vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G ...
581-831 4.74e-150

vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 pheromone receptors (V2Rs). Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are coexpressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones.


Pssm-ID: 320410 [Multi-domain]  Cd Length: 252  Bit Score: 440.56  E-value: 4.74e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 581 PLGMALGCMALSFSAITILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTV 660
Cdd:cd15283     1 PLGIALTVLSLLGSVLTAAVLVVFIKHRDTPIVKANNSELSYLLLLSLKLCFLCSLLFIGQPSTWTCMLRQTAFGISFVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 661 SVSTVLAKTITVVMAFKLTTPGRRMRGMMMTGAPKLVIPICTLIQLVLCGIWLVTSPPFIDRDIQSEHGKIVILCNKGSV 740
Cdd:cd15283    81 CISCILAKTIVVVAAFKATRPGSNIMKWFGPGQQRAIIFICTLVQVVICAIWLATSPPFPDKNMHSEHGKIILECNEGSV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 741 VAFHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAGLLM 820
Cdd:cd15283   161 VAFYCVLGYIGLLALVSFLLAFLARKLPDNFNEAKFITFSMLVFCAVWVAFVPAYISSPGKYMVAVEIFAILASSAGLLG 240
                         250
                  ....*....|.
gi 1883538153 821 CIFVPKCYVIL 831
Cdd:cd15283   241 CIFAPKCYIIL 251
7tm_3 pfam00003
7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane ...
576-826 2.95e-82

7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.


Pssm-ID: 459626 [Multi-domain]  Cd Length: 247  Bit Score: 264.14  E-value: 2.95e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 576 LAYEDPLGMALGCMALSFSAITILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPdQVTCILQQTTFG 655
Cdd:pfam00003   1 LDLSAPWGIVLEALAALGILLTLVLLVVFLLHRKTPIVKASNRSLSFLLLLGLLLLFLLAFLFIGKP-TVTCALRRFLFG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 656 VLFTVSVSTVLAKTITVVMAFKLTTPGRRMRGMMmtgapkLVIPICTLIQLVLCGIWLVTsPPFIDRDIQSEhGKIVILC 735
Cdd:pfam00003  80 VGFTLCFSCLLAKTFRLVLIFRRRKPGPRGWQLL------LLALGLLLVQVIILTEWLID-PPFPEKDNLSE-GKIILEC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 736 NKGSVVAF-HVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVY-HSTRGKVM---VVVEVFS 810
Cdd:pfam00003 152 EGSTSIAFlDFVLAYVGLLLLAGFLLAFKTRKLPDNFNEAKFITFSMLLSVLIWVAFIPMYlYGNKGKGTwdpVALAIFA 231
                         250
                  ....*....|....*.
gi 1883538153 811 ILASSAGLLMCIFVPK 826
Cdd:pfam00003 232 ILASGWVLLGLYFIPK 247
ANF_receptor pfam01094
Receptor family ligand binding region; This family includes extracellular ligand binding ...
78-408 1.61e-27

Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.


Pssm-ID: 460062 [Multi-domain]  Cd Length: 347  Bit Score: 114.79  E-value: 1.61e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  78 LLVMFFATDEINKNPYLLPNMSLMFSIIGGNCHD---LLRSLDQEYAQIDGhmnFVNYFCyldDSCATGLTgpswktslK 154
Cdd:pfam01094   3 LLAVRLAVEDINADPGLLPGTKLEYIILDTCCDPslaLAAALDLLKGEVVA---IIGPSC---SSVASAVA--------S 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 155 LAMHSSMPLVFFGPFNPNLRDHDRLPHVHQVAPKDTHLSHGMVSLMFHFRWTWIGLVISDDDQGIQFLSDLREESQRHGI 234
Cdd:pfam01094  69 LANEWKVPLISYGSTSPALSDLNRYPTFLRTTPSDTSQADAIVDILKHFGWKRVALIYSDDDYGESGLQALEDALRERGI 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 235 CLAFVNMIPENMQIymtrATIYDT--QIMTSSAKVVII--YGDMNSTLEASFRRWEELGARRIWITTTQW-DVITNKKDF 309
Cdd:pfam01094 149 RVAYKAVIPPAQDD----DEIARKllKEVKSRARVIVVccSSETARRLLKAARELGMMGEGYVWIATDGLtTSLVILNPS 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 310 TLNLFHGTITFAHHKDEIPKFRNFMQTKKTAKylvdishtilewnyfncsiSKNSSKMGHFTFNNTLQwtalhnydmals 389
Cdd:pfam01094 225 TLEAAGGVLGFRLHPPDSPEFSEFFWEKLSDE-------------------KELYENLGGLPVSYGAL------------ 273
                         330
                  ....*....|....*....
gi 1883538153 390 degynLYNAVYAVAHTYHE 408
Cdd:pfam01094 274 -----AYDAVYLLAHALHN 287
NCD3G pfam07562
Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several ...
508-561 3.11e-19

Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the pfam00003 in several receptor proteins.


Pssm-ID: 462210  Cd Length: 53  Bit Score: 81.92  E-value: 3.11e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1883538153 508 PSSVCSVACTAGFRKIHQKETADCCFDCVQCLENEVSNeTDMEQCVRCPDNKYA 561
Cdd:pfam07562   1 PSSVCSESCPPGQRKSQQGGAPVCCWDCVPCPEGEISN-TDSDTCKKCPEGQWP 53
 
Name Accession Description Interval E-value
PBP1_pheromone_receptor cd06365
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within ...
46-500 3.85e-178

Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.


Pssm-ID: 380588 [Multi-domain]  Cd Length: 464  Bit Score: 521.05  E-value: 3.85e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  46 CHFYLWKTDEPIEDSF---YNYDLSFRIAGSEYELLLVMFFATDEINKNPYLLPNMSLMFSIIGGNCHDLLRSLDQEYAQ 122
Cdd:cd06365     4 GVFPIHTFSEGKKKDFkepPSPLLCFRFSIKYYQHLLAFLFAIEEINKNPDLLPNITLGFHIYDSCSSERLALESSLSIL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 123 IDGHMNFVNYFCYLDDSCATGLTGPSWKTSLKLA---MHSSMPLVFFGPFNPNLRDHDRLPHVHQVAPKDTHLSHGMVSL 199
Cdd:cd06365    84 SGNSEPIPNYSCREQRKLVAFIGDLSSSTSVAMArilGLYKYPQISYGAFDPLLSDKVQFPSFYRTVPSDTSQSLAIVQL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 200 MFHFRWTWIGLVISDDDQGIQFLSDLREESQRHGICLAFVNMIPENMQiyMTRATIYDTQIMTSSAKVVIIYGDMNSTLE 279
Cdd:cd06365   164 LKHFGWTWVGLIISDDDYGEQFSQDLKKEMEKNGICVAFVEKIPTNSS--LKRIIKYINQIIKSSANVIIIYGDTDSLLE 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 280 ASFRRWEELGARRIWITTTQWDVITNKKDFTLNLFHGTITFAHHKDEIPKFRNFMQTKKTAKYLVDISHTILEWNYFNCS 359
Cdd:cd06365   242 LLFRLWEQLVTGKVWITTSQWDISTLPFEFYLNLFNGTLGFSQHSGEIPGFKEFLQSVHPSKYPEDIFLKTLWESYFNCK 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 360 ISKNSSKMGHF-TFNNTLQWTALHNYDMALSDEGYNLYNAVYAVAHTYHEYILQQVESQKKAKPKRYFTACQQVSSLMKT 438
Cdd:cd06365   322 WPDQNCKSLQNcCGNESLETLDVHSFDMTMSRLSYNVYNAVYAVAHALHEMLLCQPKTGPGNCSDRRNFQPWQLHHYLKK 401
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1883538153 439 RVFMNPVGELVNMKHRENQCTEYDIFIIWNFPQGLGLKVKVGSYLPCFPKSQQLHIADDL-EW 500
Cdd:cd06365   402 VQFTNPAGDEVNFDEKGDLPTKYDILNWQIFPNGTGTKVKVGTFDPSAPSGQQLIINDSMiEW 464
7tmC_V2R_pheromone cd15283
vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G ...
581-831 4.74e-150

vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 pheromone receptors (V2Rs). Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are coexpressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones.


Pssm-ID: 320410 [Multi-domain]  Cd Length: 252  Bit Score: 440.56  E-value: 4.74e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 581 PLGMALGCMALSFSAITILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTV 660
Cdd:cd15283     1 PLGIALTVLSLLGSVLTAAVLVVFIKHRDTPIVKANNSELSYLLLLSLKLCFLCSLLFIGQPSTWTCMLRQTAFGISFVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 661 SVSTVLAKTITVVMAFKLTTPGRRMRGMMMTGAPKLVIPICTLIQLVLCGIWLVTSPPFIDRDIQSEHGKIVILCNKGSV 740
Cdd:cd15283    81 CISCILAKTIVVVAAFKATRPGSNIMKWFGPGQQRAIIFICTLVQVVICAIWLATSPPFPDKNMHSEHGKIILECNEGSV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 741 VAFHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAGLLM 820
Cdd:cd15283   161 VAFYCVLGYIGLLALVSFLLAFLARKLPDNFNEAKFITFSMLVFCAVWVAFVPAYISSPGKYMVAVEIFAILASSAGLLG 240
                         250
                  ....*....|.
gi 1883538153 821 CIFVPKCYVIL 831
Cdd:cd15283   241 CIFAPKCYIIL 251
7tmC_V2R_AA_sensing_receptor-like cd15044
vomeronasal type-2 pheromone receptors, amino acid-sensing receptors and closely related ...
581-831 3.73e-91

vomeronasal type-2 pheromone receptors, amino acid-sensing receptors and closely related proteins; member of the class C family of seven-transmembrane G protein-coupled receptors; This group is composed of vomeronasal type-2 pheromone receptors (V2Rs), a subgroup of broad-spectrum amino-acid sensing receptors including calcium-sensing receptor (CaSR) and GPRC6A, as well as their closely related proteins. Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are co-expressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones. CaSR is a widely expressed GPCR that is involved in sensing small changes in extracellular levels of calcium ion to maintain a constant level of the extracellular calcium via modulating the synthesis and secretion of calcium regulating hormones, such as parathyroid hormone (PTH), in order to regulate Ca(2+)transport into or out of the extracellular fluid via kidney, intestine, and/or bone. For instance, when Ca2+ is high, CaSR downregulates PTH synthesis and secretion, leading to an increase in renal Ca2+ excretion, a decrease in intestinal Ca2+ absorption, and a reduction in release of skeletal Ca2+. GRPC6A (GPCR, class C, group 6, subtype A) is a widely expressed amino acid-sensing GPCR that is most closely related to CaSR. GPRC6A is most potently activated by the basic amino acids L-arginine, L-lysine, and L-ornithine and less potently by small aliphatic amino acids. Moreover, the receptor can be either activated or modulated by divalent cations such as Ca2+. GPRC6A is expressed in the testis, but not the ovary and specifically also binds to the osteoblast-derived hormone osteocalcin (OCN), which regulates testosterone production by the testis and male fertility independently of the hypothalamic-pituitary axis. Furthermore, GPRC6A knockout studies suggest that GRPC6A is involved in regulation of bone metabolism, male reproduction, energy homeostasis, glucose metabolism, and in activation of inflammation response, as well as prostate cancer growth and progression, among others.


Pssm-ID: 320172 [Multi-domain]  Cd Length: 251  Bit Score: 287.83  E-value: 3.73e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 581 PLGMALGCMALSFSAITILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTV 660
Cdd:cd15044     1 PLGILLVILSILGIIFVLVVGGVFVRYRNTPIVKANNRELSYLILLSLFLCFSSSLFFIGEPQDWTCKLRQTMFGVSFTL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 661 SVSTVLAKTITVVMAFKLTTPGRRMRGMMmTGAPKLVIPICTLIQLVLCGIWLVTSPPFIDRDIQSEHGKIVILCNKGSV 740
Cdd:cd15044    81 CISCILTKTLKVLLAFSADKPLTQKFLMC-LYLPILIVFTCTGIQVVICTVWLIFAPPTVEVNVSPLPRVIILECNEGSI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 741 VAFHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAGLLM 820
Cdd:cd15044   160 LAFGTMLGYIAFLAFLCFLFAFKARKLPDNYNEAKFITFGMLVFFIVWISFVPAYLSTKGKFVVAVEIIAILASSYGLLG 239
                         250
                  ....*....|.
gi 1883538153 821 CIFVPKCYVIL 831
Cdd:cd15044   240 CIFLPKCYVIL 250
7tm_3 pfam00003
7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane ...
576-826 2.95e-82

7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.


Pssm-ID: 459626 [Multi-domain]  Cd Length: 247  Bit Score: 264.14  E-value: 2.95e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 576 LAYEDPLGMALGCMALSFSAITILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPdQVTCILQQTTFG 655
Cdd:pfam00003   1 LDLSAPWGIVLEALAALGILLTLVLLVVFLLHRKTPIVKASNRSLSFLLLLGLLLLFLLAFLFIGKP-TVTCALRRFLFG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 656 VLFTVSVSTVLAKTITVVMAFKLTTPGRRMRGMMmtgapkLVIPICTLIQLVLCGIWLVTsPPFIDRDIQSEhGKIVILC 735
Cdd:pfam00003  80 VGFTLCFSCLLAKTFRLVLIFRRRKPGPRGWQLL------LLALGLLLVQVIILTEWLID-PPFPEKDNLSE-GKIILEC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 736 NKGSVVAF-HVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVY-HSTRGKVM---VVVEVFS 810
Cdd:pfam00003 152 EGSTSIAFlDFVLAYVGLLLLAGFLLAFKTRKLPDNFNEAKFITFSMLLSVLIWVAFIPMYlYGNKGKGTwdpVALAIFA 231
                         250
                  ....*....|....*.
gi 1883538153 811 ILASSAGLLMCIFVPK 826
Cdd:pfam00003 232 ILASGWVLLGLYFIPK 247
7tmC_V2R-like cd15280
vomeronasal type-2 receptor-like proteins, member of the class C family of seven-transmembrane ...
581-834 2.50e-73

vomeronasal type-2 receptor-like proteins, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 receptor-like proteins that are closely related to the V2R family of vomeronasal GPCRs. Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, generating the secondary messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones. Human V2R1-like protein, also known as putative calcium-sensing receptor-like 1 (CASRL1), is not included here because it is a nonfunctional pseudogene.


Pssm-ID: 320407 [Multi-domain]  Cd Length: 253  Bit Score: 240.46  E-value: 2.50e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 581 PLGMALGCMALSFSAITILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTV 660
Cdd:cd15280     1 ALGITLIALSIFGALVVLAVTVVYIMHRHTPLVKANDRELSFLIQMSLVITFLTSILFIGKPENWSCMARQITLALGFSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 661 SVSTVLAKTITVVMAFKLTTPGRRMRGMMMTgAPKLVIPICTLIQLVLCGIWLVTSPPFIDRDIQSEHGKIVILCNKGSV 740
Cdd:cd15280    81 CLSSILGKTISLFLRYRASKSETRLDSMHPI-YQKIIVLICVLIEVGICTAYLILEPPRMYKNTEVQNVKIIFECNEGSI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 741 VAFHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAGLLM 820
Cdd:cd15280   160 EFLCSIFGFDVFLALLCFLTAFVARKLPDNFNEGKFITFGMLVFFIVWISFVPAYLSTRGKFKVAVEIFAILASSFGLLG 239
                         250
                  ....*....|....
gi 1883538153 821 CIFVPKCYVILIRP 834
Cdd:cd15280   240 CIFVPKCYIILLKP 253
7tm_classC_mGluR-like cd13953
metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled ...
581-831 2.89e-64

metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled receptors superfamily; The class C GPCRs consist of glutamate receptors (mGluR1-8), the extracellular calcium-sensing receptors (caSR), the gamma-amino-butyric acid type B receptors (GABA-B), the vomeronasal type-2 pheromone receptors (V2R), the type 1 taste receptors (TAS1R), and the promiscuous L-alpha-amino acid receptor (GPRC6A), as well as several orphan receptors. Structurally, these receptors are typically composed of a large extracellular domain containing a Venus flytrap module which possesses the orthosteric agonist-binding site, a cysteine-rich domain (CRD) with the exception of GABA-B receptors, and the seven-transmembrane domains responsible for G protein activation. Moreover, the Venus flytrap module shows high structural homology with bacterial periplasmic amino acid-binding proteins, which serve as primary receptors in transport of a variety of soluble substrates such as amino acids and polysaccharides, among many others. The class C GPCRs exist as either homo- or heterodimers, which are essential for their function. The GABA-B1 and GABA-B2 receptors form a heterodimer via interactions between the N-terminal Venus flytrap modules and the C-terminal coiled-coiled domains. On the other hand, heterodimeric CaSRs and Tas1Rs and homodimeric mGluRs utilize Venus flytrap interactions and intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD), which can also acts as a molecular link to mediate the signal between the Venus flytrap and the 7TMs. Furthermore, members of the class C GPCRs bind a variety of endogenous ligands, ranging from amino acids, ions, to pheromones and sugar molecules, and play important roles in many physiological processes such as synaptic transmission, calcium homeostasis, and the sensation of sweet and umami tastes.


Pssm-ID: 320091 [Multi-domain]  Cd Length: 251  Bit Score: 215.95  E-value: 2.89e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 581 PLGMALGCMALSFSAITILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTV 660
Cdd:cd13953     1 PLAIVLLVLAALGLLLTIFIWVVFIRYRNTPVVKASNRELSYLLLFGILLCFLLAFLFLLPPSDVLCGLRRFLFGLSFTL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 661 SVSTVLAKTITVVMAFKLTTPGRRMRGMMMTGAPKLVIPICTLIQLVLCGIWLVTSPPFIDRDIQSeHGKIVILCNKGSV 740
Cdd:cd13953    81 VFSTLLVKTNRIYRIFKSGLRSSLRPKLLSNKSQLLLVLFLLLVQVAILIVWLILDPPKVEKVIDS-DNKVVELCCSTGN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 741 VAFHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAGLLM 820
Cdd:cd13953   160 IGLILSLVYNILLLLICTYLAFKTRKLPDNFNEARYIGFSSLLSLVIWIAFIPTYFTTSGPYRDAILSFGLLLNATVLLL 239
                         250
                  ....*....|.
gi 1883538153 821 CIFVPKCYVIL 831
Cdd:cd13953   240 CLFLPKIYIIL 250
7tmC_CaSR cd15282
calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled ...
581-831 2.34e-63

calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors; CaSR is a widely expressed GPCR that is involved in sensing small changes in extracellular levels of calcium ion to maintain a constant level of the extracellular calcium via modulating the synthesis and secretion of calcium regulating hormones, such as parathyroid hormone (PTH), in order to regulate Ca(2+)transport into or out of the extracellular fluid via kidney, intestine, and/or bone. For instance, when Ca2+ is high, CaSR downregulates PTH synthesis and secretion, leading to an increase in renal Ca2+ excretion, a decrease in intestinal Ca2+ absorption, and a reduction in release of skeletal Ca2+. CaSR is coupled to both G(q/11)-dependent activation of phospholipase and, subsequently, intracellular calcium mobilization and protein kinase C activation as well as G(i/o)-dependent inhibition of adenylate cyclase leading to inhibition of cAMP formation. CaSR is closely related to GRPC6A (GPCR, class C, group 6, subtype A), which is an amino acid-sensing GPCR that is most potently activated by the basic amino acids L-arginine, L-lysine, and L-ornithine. These receptors contain a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD), and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TASR1 receptors.


Pssm-ID: 320409 [Multi-domain]  Cd Length: 252  Bit Score: 213.66  E-value: 2.34e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 581 PLGMALGCMALSFSAITILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTV 660
Cdd:cd15282     1 PFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLICCFSSSLIFIGEPQDWTCRLRQPAFGISFVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 661 SVSTVLAKTITVVMAFKLTTPGRRMRGMMMTGAPKLVIPICTLIQLVLCGIWLVTSPPFIDRDIQSEHGKIVILCNKGSV 740
Cdd:cd15282    81 CISCILVKTNRVLLVFEAKIPTSLHRKWWGLNLQFLLVFLCTFVQIVICVIWLYTAPPSSYRNHELEDEIIFITCNEGSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 741 VAFHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAGLLM 820
Cdd:cd15282   161 MALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILASSFGLLA 240
                         250
                  ....*....|.
gi 1883538153 821 CIFVPKCYVIL 831
Cdd:cd15282   241 CIFFNKVYIIL 251
7tmC_GPRC6A cd15281
class C of seven-transmembrane G protein-coupled receptors, subtype 6A; GRPC6A (GPCR, class C, ...
583-831 2.82e-57

class C of seven-transmembrane G protein-coupled receptors, subtype 6A; GRPC6A (GPCR, class C, group 6, subtype A) is a widely expressed amino acid-sensing GPCR that is most closely related to CaSR. GPRC6A is most potently activated by the basic amino acids L-arginine, L-lysine, and L-ornithine and less potently by small aliphatic amino acids. Moreover, the receptor can be either activated or modulated by divalent cations such as Ca2+ and Mg2+. GPRC6A is expressed in the testis, but not the ovary and specifically also binds to the osteoblast-derived hormone osteocalcin (OCN), which regulates testosterone production by the testis and male fertility independently of the hypothalamic-pituitary axis. Furthermore, GPRC6A knockout studies suggest that GRPC6A is involved in regulation of bone metabolism, male reproduction, energy homeostasis, glucose metabolism, and in activation of inflammation response, as well as prostate cancer growth and progression, among others. GPRC6A has been suggested to couple to the Gq subtype of G proteins, leading to IP3 production and intracellular calcium mobilization. GPRC6A contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD), and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320408  Cd Length: 249  Bit Score: 196.54  E-value: 2.82e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 583 GMALGCMALSFSAITILVLVT--FVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTV 660
Cdd:cd15281     1 GFAIVLLILSALGVLLIFFISalFTKNLNTPVVKAGGGPLCYVILLSHFGSFISTVFFIGEPSDLTCKTRQTLFGISFTL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 661 SVSTVLAKTITVVMAFKLTTPGRRMrgMMMTGAPKLVIPICTLIQLVLCGIWLVTSPPFIDRDIqSEHGKIVILCNKGSV 740
Cdd:cd15281    81 CVSCILVKSLKILLAFSFDPKLQEL--LKCLYKPIMIVFICTGIQVIICTVWLVFYKPFVDKNF-SLPESIILECNEGSY 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 741 VAFHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAGLLM 820
Cdd:cd15281   158 VAFGLMLGYIALLAFICFIFAFKGRKLPENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEMIVILISNYGILS 237
                         250
                  ....*....|.
gi 1883538153 821 CIFVPKCYVIL 831
Cdd:cd15281   238 CTFLPKCYIIL 248
7tmC_mGluRs cd15045
metabotropic glutamate receptors, member of the class C family of seven-transmembrane G ...
585-832 7.89e-42

metabotropic glutamate receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group I mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to (Gi/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320173 [Multi-domain]  Cd Length: 253  Bit Score: 153.56  E-value: 7.89e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 585 ALGCMALSFSAI--TILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSV 662
Cdd:cd15045     3 AIGAMAFASLGIllTLFVLVVFVRYRDTPVVKASGRELSYVLLAGILLSYVMTFVLVAKPSTIVCGLQRFGLGLCFTVCY 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 663 STVLAKTITVVMAFKLTTPGRRMRGMMmtgAPKLVIPIC---TLIQLVLCGIWLVTSPPFIDRdIQSEHGKIVILCNKGS 739
Cdd:cd15045    83 AAILTKTNRIARIFRLGKKSAKRPRFI---SPRSQLVITgllVSVQVLVLAVWLILSPPRATH-HYPTRDKNVLVCSSAL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 740 VVAFHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAGL- 818
Cdd:cd15045   159 DASYLIGLAYPILLIILCTVYAFKTRKIPEGFNEAKYIGFTMYTTCIIWLAFVPLYFTTASNIEVRITTLSVSISLSATv 238
                         250
                  ....*....|....*
gi 1883538153 819 -LMCIFVPKCYVILI 832
Cdd:cd15045   239 qLACLFAPKVYIILF 253
7tmC_TAS1R3 cd15290
type 1 taste receptor subtype 3, member of the class C of seven-transmembrane G ...
595-831 5.20e-38

type 1 taste receptor subtype 3, member of the class C of seven-transmembrane G protein-coupled receptors; This group represents TAS1R3, which is a member of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320417 [Multi-domain]  Cd Length: 253  Bit Score: 142.51  E-value: 5.20e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 595 AITILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSVSTVLAKT--ITV 672
Cdd:cd15290    15 VLQCSVGVLFLKHRGTPLVQASGGPLSIFALLSLMGACLSLLLFLGQPSDVVCRLQQPLNALFLTVCLSTILSISlqIFL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 673 VMAFKLTTPG--RRMRGmmmtGAPKLVIPICTLIQLVLCGIWLVTSPPFIDRDIQSE-HGKIVILCNKGSVVAFHVVLGY 749
Cdd:cd15290    95 VTEFPKCAAShlHWLRG----PGSWLVVLICCLVQAGLCGWYVQDGPSLSEYDAKMTlFVEVFLRCPVEPWLGFGLMHGF 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 750 LGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAGLLMCIFVPKCYV 829
Cdd:cd15290   171 NGALALISFMCTFMAQKPLKQYNLARDITFSTLIYCVTWVIFIPIYAGLQVKLRSIAQVGFILLSNLGLLAAYYLPKCYL 250

                  ..
gi 1883538153 830 IL 831
Cdd:cd15290   251 LL 252
7tmC_mGluR_group1 cd15285
metabotropic glutamate receptors in group 1, member of the class C family of ...
589-831 9.20e-38

metabotropic glutamate receptors in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors; Group 1 mGluRs includes mGluR1 and mGluR5, as well as their closely related invertebrate receptors. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320412  Cd Length: 250  Bit Score: 141.62  E-value: 9.20e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 589 MALSFSAI----TILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSVST 664
Cdd:cd15285     5 VAMVFACVgilaTLFVTVVFIRHNDTPVVKASTRELSYIILAGILLCYASTFALLAKPSTISCYLQRILPGLSFAMIYAA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 665 VLAKT--ITVVMA-FKLTTPGRRMRgmMMTGAPKLVIP-ICTLIQLVLCGIWLVTSPPFIDRDIQSEhGKIVILCNKgSV 740
Cdd:cd15285    85 LVTKTnrIARILAgSKKKILTRKPR--FMSASAQVVITgILISVEVAIIVVMLILEPPDATLDYPTP-KRVRLICNT-ST 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 741 VAFHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVveVFSILASSAGLLM 820
Cdd:cd15285   161 LGFVVPLGFDFLLILLCTLYAFKTRNLPENFNEAKFIGFTMYTTCVIWLAFLPIYFGSDNKEITL--CFSVSLSATVALV 238
                         250
                  ....*....|.
gi 1883538153 821 CIFVPKCYVIL 831
Cdd:cd15285   239 FLFFPKVYIIL 249
7tmC_TAS1R1 cd15289
type 1 taste receptor subtype 1, member of the class C of seven-transmembrane G ...
595-832 1.88e-37

type 1 taste receptor subtype 1, member of the class C of seven-transmembrane G protein-coupled receptors; This group represents TAS1R1, which is a member of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320416  Cd Length: 253  Bit Score: 141.02  E-value: 1.88e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 595 AITILVLVT------FVKYKDTPIVKANNRILSYILLISLVfCFLCSLL-FIGHPDQVTCILQQTTFGVLFTVSVSTVLA 667
Cdd:cd15289     9 ALTLLLLLLagtallFALNLTTPVVKSAGGRTCFLMLGSLA-AASCSLYcHFGEPTWLACLLKQPLFSLSFTVCLSCIAV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 668 KTITVVMAFKLTTPGRRM-RGMMMTGAPKLVIPICTLIQLVLCGIWLVTSPPFIDRDIQSEHGKIVILCNKGSVVAFHVV 746
Cdd:cd15289    88 RSFQIVCIFKLASKLPRFyETWAKNHGPELFILISSAVQLLISLLWLVLNPPVPTKDYDRYPDLIVLECSQTLSVGSFLE 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 747 LGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAGLLMCIFVPK 826
Cdd:cd15289   168 LLYNCLLSISCFVFSYMGKDLPANYNEAKCITFSLLIYFISWISFFTTYSIYRGKYLMAINVLAILSSLLGIFGGYFLPK 247

                  ....*.
gi 1883538153 827 CYVILI 832
Cdd:cd15289   248 VYIILL 253
7tmC_mGluRs_group2_3 cd15934
metabotropic glutamate receptors in group 2 and 3, member of the class C family of ...
585-831 3.53e-37

metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. The mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group I mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to (Gi/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320600  Cd Length: 252  Bit Score: 140.06  E-value: 3.53e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 585 ALGCMALSFSAI--TILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSV 662
Cdd:cd15934     3 AIVPVVFALLGIlaTLFVIVVFIRYNDTPVVKASGRELSYVLLTGILLCYLMTFVLLAKPSVITCALRRLGLGLGFSICY 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 663 STVLAKTITVVMAFKlttpgrrmRGMMMTGAPKLVIP-----ICTLI---QLVLCGIWLVTSPPFIDRDIQSEhgKIVIL 734
Cdd:cd15934    83 AALLTKTNRISRIFN--------SGKRSAKRPRFISPksqlvICLGLisvQLIGVLVWLVVEPPGTRIDYPRR--DQVVL 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 735 CNKGSVVAFHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRG--KVMVVVEVFSIL 812
Cdd:cd15934   153 KCKISDSSLLISLVYNMLLIILCTVYAFKTRKIPENFNEAKFIGFTMYTTCIIWLAFVPIYFGTSNdfKIQTTTLCVSIS 232
                         250
                  ....*....|....*....
gi 1883538153 813 ASSAGLLMCIFVPKCYVIL 831
Cdd:cd15934   233 LSASVALGCLFAPKVYIIL 251
7tmC_mGluR2 cd15447
metabotropic glutamate receptor 2 in group 2, member of the class C family of ...
597-831 2.61e-35

metabotropic glutamate receptor 2 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 2 include mGluR 2 and 3. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320563  Cd Length: 254  Bit Score: 134.67  E-value: 2.61e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 597 TILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSVSTVLAKTITVVMAF 676
Cdd:cd15447    17 TLFVVGVFVKNNETPVVKASGRELCYILLLGVLLCYLMTFIFIAKPSTAVCTLRRLGLGTSFAVCYSALLTKTNRIARIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 677 KLTTPG-RRMRGMmmtgAPKLVIPICTLI---QLVLCGIWLVTSPPFIDRDIQSEHGKIVIL-CNKGSV-----VAFHVV 746
Cdd:cd15447    97 SGAKDGaQRPRFI----SPASQVAICLALiscQLLVVLIWLLVEAPGTRKETAPERRYVVTLkCNSRDSsmlisLTYNVL 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 747 LGYLGSLalgsftLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAG--LLMCIFV 824
Cdd:cd15447   173 LIILCTL------YAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGsvVLGCLFA 246

                  ....*..
gi 1883538153 825 PKCYVIL 831
Cdd:cd15447   247 PKLHIIL 253
7tmC_mGluR_group3 cd15286
metabotropic glutamate receptors in group 3, member of the class C family of ...
581-837 1.02e-34

metabotropic glutamate receptors in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320413  Cd Length: 271  Bit Score: 133.77  E-value: 1.02e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 581 PLGMA-LGCMAlsfsaiTILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFT 659
Cdd:cd15286     6 PVALAvLGIIA------TLFVLVTFVRYNDTPIVRASGRELSYVLLTGIFLCYAITFLMVAEPGVGVCSLRRLFLGLGMS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 660 VSVSTVLAKTITVVMAF----KLTTPGRrmrgmMMTGAPKLVIPI-CTLIQLVLCGIWLVTSPP--FID----RDIQSEH 728
Cdd:cd15286    80 LSYAALLTKTNRIYRIFeqgkKSVTPPR-----FISPTSQLVITFsLISVQLLGVLAWFAVDPPhaLIDyeegRTPDPEQ 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 729 GKIVILCN--KGSVVAfhvVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRG---KVM 803
Cdd:cd15286   155 ARGVLRCDmsDLSLIC---CLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQsaeKLY 231
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1883538153 804 VVVEVFSI---LASSAGLLMcIFVPKCYVILIRPDSN 837
Cdd:cd15286   232 IQTATLTVsmsLSASVSLGM-LYMPKVYVILFHPEQN 267
7tmC_mGluR4 cd15452
metabotropic glutamate receptor 4 in group 3, member of the class C family of ...
597-837 1.77e-34

metabotropic glutamate receptor 4 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320568 [Multi-domain]  Cd Length: 327  Bit Score: 134.72  E-value: 1.77e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 597 TILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSVSTVLAKTITVVMAF 676
Cdd:cd15452    17 TLFVVVTFVRYNDTPIVKASGRELSYVLLTGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 677 KlttpgrrmRGMMMTGAPKLVIPICTL--------IQLVLCGIWLVTSP--PFID----RDIQSEHGKIVILCNKgSVVA 742
Cdd:cd15452    97 E--------QGKRSVSAPRFISPASQLvitfslisLQLLGVCVWFLVDPshSVVDyedqRTPDPQFARGVLKCDI-SDLS 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 743 FHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRG---KVMVVVEVFSI---LASSA 816
Cdd:cd15452   168 LICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTSQsaeKMYIQTTTLTIsvsLSASV 247
                         250       260
                  ....*....|....*....|.
gi 1883538153 817 GLLMcIFVPKCYVILIRPDSN 837
Cdd:cd15452   248 SLGM-LYMPKVYVILFHPEQN 267
PBP1_CaSR cd06364
ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors ...
64-500 2.64e-34

ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily. CaSR provides feedback control of extracellular calcium homeostasis by responding sensitively to acute fluctuations in extracellular ionized Ca2+ concentration. This ligand-binding domain has homology to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). CaSR is widely expressed in mammalian tissues and is active in tissues that are not directly involved in extracellular calcium homeostasis. Moreover, CaSR responds to aromatic, aliphatic, and polar amino acids, but not to positively charged or branched chain amino acids, which suggests that changes in plasma amino acid levels are likely to modulate whole body calcium metabolism. Additionally, the family C GPCRs includes at least two receptors with broad-spectrum amino acid-sensing properties: GPRC6A which recognizes basic and various aliphatic amino acids, its gold-fish homolog the 5.24 chemoreceptor, and a specific taste receptor (T1R) which responds to aliphatic, polar, charged, and branched amino acids, but not to aromatic amino acids.


Pssm-ID: 380587 [Multi-domain]  Cd Length: 473  Bit Score: 137.39  E-value: 2.64e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  64 YDLSFRiagsEYELLLVMFFATDEINKNPYLLPNMSLMFSIIGgNCHDLLRSLDQEYAQIDGHMNFVnyfcyLDDSCAT- 142
Cdd:cd06364    29 EGFNFR----GFRWAQTMIFAIEEINNSPDLLPNITLGYRIYD-SCATISKALRAALALVNGQEETN-----LDERCSGg 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 143 -------GLTGpswkTSLKLAMHSSMplvffGPFNPN----------LRDHDRLPHVHQVAPKDTHLSHGMVSLMFHFRW 205
Cdd:cd06364    99 ppvaaviGESG----STLSIAVARTL-----GLFYIPqvsyfascacLSDKKQFPSFLRTIPSDYYQSRALAQLVKHFGW 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 206 TWIGLVISDDDQGIQFLSDLREESQRHGICLAFVNMIPEnmqiYMTRATIYDT--QIMTSSAKVVIIY---GDMNSTLEA 280
Cdd:cd06364   170 TWVGAIASDDDYGRNGIKAFLEEAEKLGICIAFSETIPR----TYSQEKILRIveVIKKSTAKVIVVFsseGDLEPLIKE 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 281 SFRRWEelgARRIWITTTQWdvITNKKDFTLNLFH---GTITFAHHKDEIPKFRNFMQTKKTAKYLVDiSHTILEWNY-F 356
Cdd:cd06364   246 LVRQNI---TGRQWIASEAW--ITSSLLATPEYFPvlgGTIGFAIRRGEIPGLKEFLLRVHPSKSPSN-PFVKEFWEEtF 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 357 NCSISKNSSKMGHFTFNN------TLQwTALHNY-DMALSDEGYNLYNAVYAVAHTYHEyILQQVESQ-----------K 418
Cdd:cd06364   320 NCSLSSSSKSNSSSSSRPpctgseNLE-NVQNPYtDVSQLRISYNVYKAVYAIAHALHD-LLQCEPGKgpfsngscadiK 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 419 KAKPkryftacQQVSSLMKTRVFMNPVGELVNMKHRENQCTEYDIfIIWNFPQGLGLK-VKVGSYLPCFPKSQQLHIADD 497
Cdd:cd06364   398 KVEP-------WQLLYYLKHVNFTTKFGEEVYFDENGDPVASYDI-INWQLSDDGTIQfVTVGYYDASAPSGEELVINES 469

                  ....
gi 1883538153 498 -LEW 500
Cdd:cd06364   470 kILW 473
PBP1_GPCR_family_C-like cd06350
ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory ...
75-374 5.99e-33

ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate; categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (m; Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The metabotropic glutamate receptors (mGluR) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. The mGluRs are coupled to G proteins and are thus distinct from the iGluRs which internally contain ligand-gated ion channels. The mGluR structure is divided into three regions: the extracellular region, the seven-spanning transmembrane region and the cytoplasmic region. The extracellular region is further divided into the ligand-binding domain (LBD) and the cysteine-rich domain. The LBD has sequence similarity to the LIVBP, which is a bacterial periplasmic protein (PBP), as well as to the extracellular region of both iGluR and the gamma-aminobutyric acid (GABA)b receptor. iGluRs are divided into three main subtypes based on pharmacological profile: NMDA, AMPA, and kainate receptors. All family C GPCRs have a large extracellular N terminus that contain a domain with homology to bacterial periplasmic amino acid-binding proteins.


Pssm-ID: 380573  Cd Length: 350  Bit Score: 130.88  E-value: 5.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  75 YELLLVMFFATDEINKNPYLLPNMSLMFsIIGGNCHDLLRSLDQEYAqidghmNFVNYFCYLDDSCATGLTGP------- 147
Cdd:cd06350    27 VQLVEAMIYAIEEINNDSSLLPNVTLGY-DIRDTCSSSSVALESSLE------FLLDNGIKLLANSNGQNIGPpnivavi 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 148 ---SWKTSL---KLAMHSSMPLVFFGPFNPNLRDHDRLPHVHQVAPKDTHLSHGMVSLMFHFRWTWIGLVISDDDQGIQF 221
Cdd:cd06350   100 gaaSSSVSIavaNLLGLFKIPQISYASTSPELSDKIRYPYFLRTVPSDTLQAKAIADLLKHFNWNYVSTVYSDDDYGRSG 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 222 LSDLREESQRHGICLAFVNMIPENmqiymTRATIYDTQI----MTSSAKVVIIYGDMNSTLEAsfrrWEELGAR----RI 293
Cdd:cd06350   180 IEAFEREAKERGICIAQTIVIPEN-----STEDEIKRIIdklkSSPNAKVVVLFLTESDAREL----LKEAKRRnltgFT 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 294 WITTTQW---DVITNKkdfTLNLFHGTITFAHHKDEIPKFRNFMQTKktAKYLVD---------------ISHTILEWNY 355
Cdd:cd06350   251 WIGSDGWgdsLVILEG---YEDVLGGAIGVVPRSKEIPGFDDYLKSY--APYVIDavyatvkfdengdgnGGYDIVNLQR 325
                         330
                  ....*....|....*....
gi 1883538153 356 FNCSISKNsSKMGHFTFNN 374
Cdd:cd06350   326 TGTGNYEY-VEVGTWDSNS 343
7tmC_mGluR_group2 cd15284
metabotropic glutamate receptors in group 2, member of the class C family of ...
597-831 7.33e-33

metabotropic glutamate receptors in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 2 include mGluR 2 and 3. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320411  Cd Length: 254  Bit Score: 127.66  E-value: 7.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 597 TILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSVSTVLAKTITVVMAF 676
Cdd:cd15284    17 TLFVIGVFIKHNNTPLVKASGRELCYILLFGVFLCYCMTFIFIAKPSPAICTLRRLGLGTSFAVCYSALLTKTNRIARIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 677 KLTTPG-RRMRGMmmtgAPKLVIPIC---TLIQLVLCGIWLVTSPPFIDRDIQSEHGKIVIL-CNKGSvVAFHVVLGYLG 751
Cdd:cd15284    97 SGVKDGaQRPRFI----SPSSQVFIClalISVQLLVVSVWLLVEAPGTRRYTLPEKRETVILkCNVRD-SSMLISLTYDV 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 752 SLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAG--LLMCIFVPKCYV 829
Cdd:cd15284   172 VLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGfvVLGCLFAPKVHI 251

                  ..
gi 1883538153 830 IL 831
Cdd:cd15284   252 IL 253
7tmC_mGluR3 cd15448
metabotropic glutamate receptor 3 in group 2, member of the class C family of ...
597-831 7.94e-31

metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 2 include mGluR 2 and 3. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320564  Cd Length: 254  Bit Score: 121.98  E-value: 7.94e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 597 TILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSVSTVLAKTITVVMAF 676
Cdd:cd15448    17 TCMVITVFIKHNNTPLVKASGRELCYILLFGVFLSYCMTFFFIAKPSPVICTLRRLGLGTSFAVCYSALLTKTNCIARIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 677 KLTTPGRRMRGMMmtgAPKLVIPIC---TLIQLVLCGIWLVTSPPFIDRDIQSEHGKIVIL-CN-KGSvvAFHVVLGYLG 751
Cdd:cd15448    97 DGVKNGAQRPKFI---SPSSQVFIClslILVQIVVVSVWLILEAPGTRRYTLPEKRETVILkCNvKDS--SMLISLTYDV 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 752 SLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAG--LLMCIFVPKCYV 829
Cdd:cd15448   172 VLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGfvVLGCLFAPKVHI 251

                  ..
gi 1883538153 830 IL 831
Cdd:cd15448   252 IL 253
7tmC_mGluR6 cd15453
metabotropic glutamate receptor 6 in group 3, member of the class C family of ...
597-843 1.30e-30

metabotropic glutamate receptor 6 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320569 [Multi-domain]  Cd Length: 273  Bit Score: 121.68  E-value: 1.30e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 597 TILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSVSTVLAKTITVVMAF 676
Cdd:cd15453    17 TTTVVITFVRFNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAFRRLFLGLGTTLSYSALLTKTNRIYRIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 677 KlttpgrrmRGMMMTGAPKLVIPICTLI--------QLVLCGIWLVTSPP--FID----RDIQSEHGKIVILCNKgSVVA 742
Cdd:cd15453    97 E--------QGKRSVTPPPFISPTSQLVitfsltslQVVGVIAWLGAQPPhsVIDyeeqRTVDPEQARGVLKCDM-SDLS 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 743 FHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRG---KVMVVVEVFSI---LASSA 816
Cdd:cd15453   168 LIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQsaeKIYIQTTTLTVslsLSASV 247
                         250       260
                  ....*....|....*....|....*..
gi 1883538153 817 GLLMcIFVPKCYVILIRPDSNfIQNHK 843
Cdd:cd15453   248 SLGM-LYVPKTYVILFHPEQN-VQKRK 272
7tmC_mGluR8 cd15454
metabotropic glutamate receptor 8 in group 3, member of the class C family of ...
586-837 2.30e-30

metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320570 [Multi-domain]  Cd Length: 311  Bit Score: 122.05  E-value: 2.30e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 586 LGCMALSFsaitilVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSVSTV 665
Cdd:cd15454    12 LGIIATTF------VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYAITFLMIATPDTGICSFRRVFLGLGMCFSYAAL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 666 LAKTITVVMAFKlttpgrrmRGMMMTGAPKLVIPICTL--------IQLVLCGIWLVTSPPFI------DRDIQSEHGKI 731
Cdd:cd15454    86 LTKTNRIHRIFE--------QGKKSVTAPKFISPASQLvitfslisVQLLGVFVWFAVDPPHTivdygeQRTLDPEKARG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 732 VILCNKgSVVAFHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHST-----RGKVMVVV 806
Cdd:cd15454   158 VLKCDI-SDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTaqsaeRMYIQTTT 236
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1883538153 807 EVFSILASSAGLLMCIFVPKCYVILIRPDSN 837
Cdd:cd15454   237 LTISMSLSASVSLGMLYMPKVYIIIFHPEQN 267
7tmC_TAS1R cd15046
type 1 taste receptors, member of the class C of seven-transmembrane G protein-coupled ...
586-831 2.80e-30

type 1 taste receptors, member of the class C of seven-transmembrane G protein-coupled receptors; This subfamily represents the type I taste receptors (TAS1Rs) that belongs to the class C family of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320174 [Multi-domain]  Cd Length: 253  Bit Score: 120.32  E-value: 2.80e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 586 LGCMALSFSAITILVLVTFvkykDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSVSTV 665
Cdd:cd15046    10 AALGLLSTLAILVIFWRNF----NTPVVRSAGGPMCFLMLTLLLVAYMSVPVYFGPPKVSTCLLRQALFPLCFTVCLACI 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 666 LAKTITVVMAFKLTT--PGRRMRGMMMTGaPKLVIPICTLIQLVLCGIWLVTSPPFIDRDIQSEHGKIVILCNKGSVVAF 743
Cdd:cd15046    86 AVRSFQIVCIFKMASrfPRAYSYWVKYHG-PYVSIAFITVLKMVIVVIGMLATPPSPTTDTDPDPKITIVSCNPNYRNSS 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 744 HVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAGLLMCIF 823
Cdd:cd15046   165 LFNTSLDLLLSVVCFSFSYMGKDLPTNYNEAKFITFSLTFYFTSWISFCTFMLAYSGVLVTIVDLLATLLSLLAFSLGYF 244

                  ....*...
gi 1883538153 824 VPKCYVIL 831
Cdd:cd15046   245 LPKCYIIL 252
7tmC_mGluR5 cd15450
metabotropic glutamate receptor 5 in group 1, member of the class C family of ...
597-831 1.55e-29

metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors; Group 1 mGluRs includes mGluR1 and mGluR5, as well as their closely related invertebrate receptors. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320566  Cd Length: 250  Bit Score: 118.16  E-value: 1.55e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 597 TILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSVSTVLAKT--ITVVM 674
Cdd:cd15450    17 TLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTnrIARIL 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 675 AFKLTTPGRRMRGMMMTGAPKLVIPICTLIQLVLCGIWLVTSPPFIDRDIQSEHgKIVILCNKGSvVAFHVVLGYLGSLA 754
Cdd:cd15450    97 AGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIR-EVYLICNTTN-LGVVTPLGYNGLLI 174
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1883538153 755 LGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVveVFSILASSAGLLMCIFVPKCYVIL 831
Cdd:cd15450   175 LSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITM--CFSVSLSATVALGCMFVPKVYIIL 249
7tmC_mGluR7 cd15451
metabotropic glutamate receptor 7 in group 3, member of the class C family of ...
597-843 5.29e-28

metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320567  Cd Length: 307  Bit Score: 115.12  E-value: 5.29e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 597 TILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSVSTVLAKTITVVMAF 676
Cdd:cd15451    17 TIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRIFLGLGMCISYAALLTKTNRIYRIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 677 KlttpgrrmRGMMMTGAPKLVIPICTL--------IQLVLCGIWLVTSPP--FIDRD----IQSEHGKIVILCNkgsVVA 742
Cdd:cd15451    97 E--------QGKKSVTAPRLISPTSQLaitsslisVQLLGVLIWFAVDPPniIIDYDeqktMNPEQARGVLKCD---ITD 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 743 FHVV--LGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRG---KVMVVVEVFSI---LAS 814
Cdd:cd15451   166 LQIIcsLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQsaeKLYIQTTTLTIsmnLSA 245
                         250       260
                  ....*....|....*....|....*....
gi 1883538153 815 SAGLLMcIFVPKCYVILIRPDSNfIQNHK 843
Cdd:cd15451   246 SVALGM-LYMPKVYIIIFHPELN-VQKRK 272
PBP1_mGluR cd06362
ligand binding domain of metabotropic glutamate receptors (mGluR); Ligand binding domain of ...
81-410 8.68e-28

ligand binding domain of metabotropic glutamate receptors (mGluR); Ligand binding domain of the metabotropic glutamate receptors (mGluR), which are members of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses. mGluRs bind to glutamate and function as an excitatory neurotransmitter; they are involved in learning, memory, anxiety, and the perception of pain. Eight subtypes of mGluRs have been cloned so far, and are classified into three groups according to their sequence similarities, transduction mechanisms, and pharmacological profiles. Group I is composed of mGlu1R and mGlu5R that both stimulate PLC hydrolysis. Group II includes mGlu2R and mGlu3R, which inhibit adenylyl cyclase, as do mGlu4R, mGlu6R, mGlu7R, and mGlu8R, which form group III.


Pssm-ID: 380585 [Multi-domain]  Cd Length: 460  Bit Score: 117.78  E-value: 8.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  81 MFFATDEINKNPYLLPNMSLMFSIIGGnCHD----LLRSLDQEYAQIdGHMNFVNYFCYLDDSCAT----------GLTG 146
Cdd:cd06362    36 MLFAIDEINSRPDLLPNITLGFVILDD-CSSdttaLEQALHFIRDSL-LSQESAGFCQCSDDPPNLdesfqfydvvGVIG 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 147 PsWKTSLKLAMHS-----SMPLVFFGPFNPNLRDHDRLPHVHQVAPKDTHLSHGMVSLMFHFRWTWIGLVISDDDQGIQF 221
Cdd:cd06362   114 A-ESSSVSIQVANllrlfKIPQISYASTSDELSDKERYPYFLRTVPSDSFQAKAIVDILLHFNWTYVSVVYSEGSYGEEG 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 222 LSDLREESQRHGICLAFVNMIPENMqiymtRATIYDTQIMT----SSAKVVIIY---GDMNSTLEASFRRweELGARRIW 294
Cdd:cd06362   193 YKAFKKLARKAGICIAESERISQDS-----DEKDYDDVIQKllqkKNARVVVLFadqEDIRGLLRAAKRL--GASGRFIW 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 295 ITTTQWDVITNKKDFTLNLFHGTITFAHHKDEIPKFRNFMQTkktakyLVDISHTILEW------NYFNCSisknsskmg 368
Cdd:cd06362   266 LGSDGWGTNIDDLKGNEDVALGALTVQPYSEEVPRFDDYFKS------LTPSNNTRNPWfrefwqELFQCS--------- 330
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1883538153 369 hftFNNTLQWTALHNYDMALSDEGYN-------LYNAVYAVAHTYHEYI 410
Cdd:cd06362   331 ---FRPSRENSCNDDKLLINKSEGYKqeskvsfVIDAVYAFAHALHKMH 376
ANF_receptor pfam01094
Receptor family ligand binding region; This family includes extracellular ligand binding ...
78-408 1.61e-27

Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.


Pssm-ID: 460062 [Multi-domain]  Cd Length: 347  Bit Score: 114.79  E-value: 1.61e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  78 LLVMFFATDEINKNPYLLPNMSLMFSIIGGNCHD---LLRSLDQEYAQIDGhmnFVNYFCyldDSCATGLTgpswktslK 154
Cdd:pfam01094   3 LLAVRLAVEDINADPGLLPGTKLEYIILDTCCDPslaLAAALDLLKGEVVA---IIGPSC---SSVASAVA--------S 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 155 LAMHSSMPLVFFGPFNPNLRDHDRLPHVHQVAPKDTHLSHGMVSLMFHFRWTWIGLVISDDDQGIQFLSDLREESQRHGI 234
Cdd:pfam01094  69 LANEWKVPLISYGSTSPALSDLNRYPTFLRTTPSDTSQADAIVDILKHFGWKRVALIYSDDDYGESGLQALEDALRERGI 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 235 CLAFVNMIPENMQIymtrATIYDT--QIMTSSAKVVII--YGDMNSTLEASFRRWEELGARRIWITTTQW-DVITNKKDF 309
Cdd:pfam01094 149 RVAYKAVIPPAQDD----DEIARKllKEVKSRARVIVVccSSETARRLLKAARELGMMGEGYVWIATDGLtTSLVILNPS 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 310 TLNLFHGTITFAHHKDEIPKFRNFMQTKKTAKylvdishtilewnyfncsiSKNSSKMGHFTFNNTLQwtalhnydmals 389
Cdd:pfam01094 225 TLEAAGGVLGFRLHPPDSPEFSEFFWEKLSDE-------------------KELYENLGGLPVSYGAL------------ 273
                         330
                  ....*....|....*....
gi 1883538153 390 degynLYNAVYAVAHTYHE 408
Cdd:pfam01094 274 -----AYDAVYLLAHALHN 287
7tmC_mGluR1 cd15449
metabotropic glutamate receptor 1 in group 1, member of the class C family of ...
579-831 3.71e-26

metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors; Group 1 mGluRs includes mGluR1 and mGluR5, as well as their closely related invertebrate receptors. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320565  Cd Length: 250  Bit Score: 108.18  E-value: 3.71e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 579 EDPLGMALGCMALsfsAITILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLF 658
Cdd:cd15449     2 ESIIAVAFSCLGI---LVTMFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 659 TVSVSTVLAKT--ITVVMAFKLTTPGRRMRGMMMTGAPKLVIPICTLIQLVLCGIWLVTSPPFIDRDIQSEHgKIVILCN 736
Cdd:cd15449    79 AMCYSALVTKTnrIARILAGSKKKICTRKPRFMSAWAQVVIASILISVQLTLVVTLIIMEPPMPILSYPSIK-EVYLICN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 737 KgSVVAFHVVLGYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKvmVVVEVFSILASSA 816
Cdd:cd15449   158 T-SNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK--IITTCFAVSLSVT 234
                         250
                  ....*....|....*
gi 1883538153 817 GLLMCIFVPKCYVIL 831
Cdd:cd15449   235 VALGCMFTPKMYIII 249
7tmC_TAS1R2a-like cd15287
type 1 taste receptor subtype 2a and similar proteins, member of the class C of ...
595-831 6.43e-26

type 1 taste receptor subtype 2a and similar proteins, member of the class C of seven-transmembrane G protein-coupled receptors; This group includes TAS1R2a and its similar proteins found in fish. They are members of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320414  Cd Length: 252  Bit Score: 107.46  E-value: 6.43e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 595 AITILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSVSTVLAKTITVVM 674
Cdd:cd15287    15 GLTLAVSVLFAINYNTPVVRSAGGPMCFLILGCLSLCSVSVFFYFGKPTVASCILRYFPFLLFYTVCLACFVVRSFQIVC 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 675 AFKLTTPGRRMRGMMMTGAPK-LVIPICTLIQLVLCGIWLVTSPPFIDRDIQSEHGKIVILCNkGSVVAFHVVLGYLGSL 753
Cdd:cd15287    95 IFKIAAKFPKLHSWWVKYHGQwLLIAVAFVIQALLLITGFSFSPPKPYNDTSWYPDKIILSCD-INLKATSMSLVLLLSL 173
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1883538153 754 ALGSFTLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGKVMVVVEVFSILASSAGLLMCIFVPKCYVIL 831
Cdd:cd15287   174 CCLCFIFSYMGKDLPKNYNEAKAITFCLLLLILTWIIFATEYMLYRGKYIQLLNALAVLSSLYSFLLWYFLPKCYIII 251
PBP1_taste_receptor cd06363
ligand-binding domain of the T1R taste receptor; Ligand-binding domain of the T1R taste ...
75-494 3.01e-23

ligand-binding domain of the T1R taste receptor; Ligand-binding domain of the T1R taste receptor. The T1R is a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptors, GABAb receptors, the calcium-sensing receptor (CaSR), the V2R pheromone receptors, and a small group of uncharacterized orphan receptors.


Pssm-ID: 380586 [Multi-domain]  Cd Length: 418  Bit Score: 103.16  E-value: 3.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  75 YELLLVMFFATDEINKNPYLLPNMSLMFSI-----IGGNCHDLLRSLDQE-YAQIDGHMNFVNYfcyldDSCATGLTGP- 147
Cdd:cd06363    42 YHLAQAMRFAVEEINNSSDLLPGVTLGYEIfdtcsDAVNFRPTLSFLSQNgSHDIEVQCNYTNY-----QPRVVAVIGPd 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 148 -SWKTSL--KLAMHSSMPLVFFGPFNPNLRDHDRLPHVHQVAPKDTHLSHGMVSLMFHFRWTWIGLVISDDDQGIQFLSD 224
Cdd:cd06363   117 sSELALTtaKLLGFFLMPQISYGASSEELSNKLLYPSFLRTVPSDKYQVEAMVQLLQEFGWNWVAFLGSDDEYGQDGLQL 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 225 LREESQRHGICLAFVNMIPENMQiymTRATIYDT--QIMTSSAKVVIIYGdmNSTLEASFrrWEELGARRI----WITTT 298
Cdd:cd06363   197 FSEKAANTGICVAYQGLIPTDTD---PKPKYQDIlkKINQTKVNVVVVFA--PKQAAKAF--FEEVIRQNLtgkvWIASE 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 299 QW---DVITNKKDFTLnlfHGT-ITFAHHKDEIPKFRNFmqTKKTAkylvdishtilewnyfncsisknsskmghftfnn 374
Cdd:cd06363   270 AWslnDTVTSLPGIQS---IGTvLGFAIQTGTLPGFQEF--IYAFA---------------------------------- 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 375 tlqwtalhnydmalsdegYNLYNAVYAVAHTYHEyILQ----QVESQKKAKPKRYFTACQQVS-SLMKTRVFMNPVGelv 449
Cdd:cd06363   311 ------------------FSVYAAVYAVAHALHN-LLGcnsgACPKGRVVYPWQLLEELKKVNfTLLNQTIRFDENG--- 368
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1883538153 450 nmkhreNQCTEYDIfIIWNFPQGLGLKVKVGSYlpcFPKSQQLHI 494
Cdd:cd06363   369 ------DPNFGYDI-VQWIWNNSSWTFEVVGSY---STYPIQLTI 403
7tmC_TAS1R2 cd15288
type 1 taste receptor subtype 2, member of the class C of seven-transmembrane G ...
590-831 1.32e-20

type 1 taste receptor subtype 2, member of the class C of seven-transmembrane G protein-coupled receptors; This group represents TAS1R2, which is a member of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320415  Cd Length: 254  Bit Score: 92.16  E-value: 1.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 590 ALSFSAiTILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPDQVTCILQQTTFGVLFTVSVSTVLAKT 669
Cdd:cd15288    11 ALGFLS-TLAILVIFGRHFQTPVVRSAGGRMCFLMLAPLLVAYVNVPVYVGIPTVFTCLCRQTLFPLCFTVCISCIAVRS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 670 ITVVMAFKLTTPGRRMRGMMMT-GAPKLVIPICTLIQLVLCGIWLVTSPPFIDRDIQSEHGKIVIL-CNKGSVVAFHVVL 747
Cdd:cd15288    90 FQIVCIFKMARRLPRAYSYWVKyNGPYVFVALITLLKVVIVVINVLAHPTAPTTRADPDDPQVMILqCNPNYRLALLFNT 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 748 GYLGSLALGSFTLAFLARNLPDTFNEAKFLTFSMLVF--CSVWI-TFLPVYhstRGKVMVVVEVFSILASSAGLLMCIFV 824
Cdd:cd15288   170 SLDLLLSVLGFCFAYMGKELPTNYNEAKFITLCMTFYfaSSVFLcTFMSVY---EGVLVTIFDALVTVINLLGISLGYFG 246

                  ....*..
gi 1883538153 825 PKCYVIL 831
Cdd:cd15288   247 PKCYMIL 253
PBP1_GPC6A-like cd06361
ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a ...
79-336 2.25e-19

ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor; This family includes the ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor, and its fish homolog, the 5.24 chemoreceptor. GPRC6A is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses.


Pssm-ID: 380584 [Multi-domain]  Cd Length: 401  Bit Score: 91.28  E-value: 2.25e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  79 LVMFFATDEINKNPyLLPNMSLMFSIIGgNCHDLLRSLDQEyaqidghMNFVNYFCYLDDSCATGLTGP----------- 147
Cdd:cd06361    39 LAMIHAIEMINNST-LLPGIKLGYEIYD-TCSDVTKALQAT-------LRLLSKFNSSNELLECDYTDYvppvkavigas 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 148 ----SWKTSLKLAMHSsMPLVFFGPFNPNLRDHDRLPHVHQVAPKDTHLSHGMVSLMFHFRWTWIGLVISDDDQGIQFLS 223
Cdd:cd06361   110 yseiSIAVARLLNLQL-IPQISYESSAPILSDKLRFPSFLRTVPSDFHQTKAMAKLISHFGWNWVGIIYTDDDYGRSALE 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 224 DLREESQRHGICLAFVNMIPEN-----MQIYMTRaTIyDTQIMTSSAKVVIIYGDmNSTLEASFRRWEELGARRIWITTT 298
Cdd:cd06361   189 SFIIQAEAENVCIAFKEVLPAYlsdptMNVRIND-TI-QTIQSSSQVNVVVLFLK-PSLVKKLFKEVIERNISKIWIASD 265
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1883538153 299 QWDV---ITNKKDftLNLFHGTITFAHHKDEIPKFRNFMQT 336
Cdd:cd06361   266 NWSTareILKMPN--INKVGKILGFTFKSGNISSFHNYLKN 304
NCD3G pfam07562
Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several ...
508-561 3.11e-19

Nine Cysteines Domain of family 3 GPCR; This conserved sequence contains several highly-conserved Cys residues that are predicted to form disulphide bridges. It is predicted to lie outside the cell membrane, tethered to the pfam00003 in several receptor proteins.


Pssm-ID: 462210  Cd Length: 53  Bit Score: 81.92  E-value: 3.11e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1883538153 508 PSSVCSVACTAGFRKIHQKETADCCFDCVQCLENEVSNeTDMEQCVRCPDNKYA 561
Cdd:pfam07562   1 PSSVCSESCPPGQRKSQQGGAPVCCWDCVPCPEGEISN-TDSDTCKKCPEGQWP 53
PBP1_glutamate_receptors-like cd06269
ligand-binding domain of family C G-protein couples receptors (GPCRs), membrane bound guanylyl ...
80-361 3.74e-15

ligand-binding domain of family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as natriuretic peptide receptors (NPRs), and N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of ionotropic glutamate rece; This CD represents the ligand-binding domain of the family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs), and the N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the ionotropic glutamate receptors, all of which are structurally similar and related to the periplasmic-binding fold type 1 family. The family C GPCRs consists of metabotropic glutamate receptor (mGluR), a calcium-sensing receptor (CaSR), gamma-aminobutyric acid receptor (GABAbR), the promiscuous L-alpha-amino acid receptor GPR6A, families of taste and pheromone receptors, and orphan receptors. Truncated splicing variants of the orphan receptors are not included in this CD. The family C GPCRs are activated by endogenous agonists such as amino acids, ions, and sugar based molecules. Their amino terminal ligand-binding region is homologous to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). The ionotropic glutamate receptors (iGluRs) have an integral ion channel and are subdivided into three major groups based on their pharmacology and structural similarities: NMDA receptors, AMPA receptors, and kainate receptors. The family of membrane bound guanylyl cyclases is further divided into three subfamilies: the ANP receptor (GC-A)/C-type natriuretic peptide receptor (GC-B), the heat-stable enterotoxin receptor (GC-C)/sensory organ specific membrane GCs such as retinal receptors (GC-E, GC-F), and olfactory receptors (GC-D and GC-G).


Pssm-ID: 380493 [Multi-domain]  Cd Length: 332  Bit Score: 77.46  E-value: 3.74e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  80 VMFFATDEINKNPYLLPNMSLMFSIIGGNCHD---LLRSLDQEYA-QIDGHMnfvnyfcylddscatGLTGPSWKTSL-K 154
Cdd:cd06269    21 AFELALSDVNSRPDLLPKTTLGLAIRDSECNPtqaLLSACDLLAAaKVVAIL---------------GPGCSASAAPVaN 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 155 LAMHSSMPLVFFGPFNPNLRDHDRLPHVHQVAPKDTHLSHGMVSLMFHFRWTWIGLVISDDDQGIQFLSDLREESQRHGI 234
Cdd:cd06269    86 LARHWDIPVLSYGATAPGLSDKSRYAYFLRTVPPDSKQADAMLALVRRLGWNKVVLIYSDDEYGEFGLEGLEELFQEKGG 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 235 CLAFVNMIPENMQIYMTRATiydTQIMTSSAKVVII--YGDMNSTLEASFRRWEELGARRIWITTTQW-DVITNKKDFTL 311
Cdd:cd06269   166 LITSRQSFDENKDDDLTKLL---RNLRDTEARVIILlaSPDTARSLMLEAKRLDMTSKDYVWFVIDGEaSSSDEHGDEAR 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1883538153 312 NLFHGTITFAHHKDEIPKFRNFMQTKKTAKYLVDISHTIL-EWNYFNCSIS 361
Cdd:cd06269   243 QAAEGAITVTLIFPVVKEFLKFSMELKLKSSKRKQGLNEEyELNNFAAFFY 293
7tmC_GABA-B-like cd15047
gamma-aminobutyric acid type B receptor and related proteins, member of the class C family of ...
581-826 1.08e-10

gamma-aminobutyric acid type B receptor and related proteins, member of the class C family of seven-transmembrane G protein-coupled receptors; The type B receptor for gamma-aminobutyric acid, GABA-B, is activated by its endogenous ligand GABA, the principal inhibitory neurotransmitter. The functional GABA-B receptor is an obligatory heterodimer composed of two related subunits, GABA-B1, which is primarily involved in GABA ligand binding, and GABA-B2, which is responsible for both G-protein coupling and trafficking of the heterodimer to the plasma membrane. Activation of GABA-B couples to G(i/o)-type G proteins, which in turn modulate three major downstream effectors: adenylate cyclase, voltage-sensitive Ca2+ channels, and inwardly-rectifying K+ channels. Consequently, GABA-B receptor produces slow and sustained inhibitory responses by decreased neurotransmitter release via inhibition of Ca2+ channels and by postsynaptic hyperpolarization via the activation of K+ channels through the G-protein beta-gamma dimer. The GABA-B is expressed in both pre- and postsynaptic sites of glutamatergic and GABAergic neurons in the brain where it regulates synaptic activity. Thus, the GABA-B receptor agonist, baclofen, is used to treat muscle tightness and cramping caused by spasticity in multiple sclerosis patients. Moreover, GABA-B antagonists improves cognitive performance in mammals, while GABA-B agonists suppress cognitive behavior. In most of the class C family members, the extracellular Venus-flytrap domain in the N-terminus is connected to the seven-transmembrane (7TM) via a cysteine-rich domain (CRD). However, in the GABA-B receptor, the CRD is absent in both subunits and the Venus-flytrap ligand-binding domain is directly connected to the 7TM via a 10-15 amino acids linker, suggesting that GABA-B receptor may utilize a different activation mechanism. Also included in this group are orphan receptors, GPR156 and GPR158, which are closely related to the GABA-B receptor family.


Pssm-ID: 320175  Cd Length: 263  Bit Score: 62.96  E-value: 1.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 581 PLGMALGCMALSFSAITILVLVTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGH---PDQVTCILQQTTFGVL 657
Cdd:cd15047     1 PLFIVFTVLSGIGILLALVFLIFNIKFRKNRVIKMSSPLFNNLILLGCILCYISVILFGLDdskPSSFLCTARPWLLSIG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 658 FTVSVSTVLAKTITVVMAFKlttpGRRMRGMMMTGApKLVIPICTL--IQLVLCGIWLVTSPP-------FIDRDIQSEH 728
Cdd:cd15047    81 FTLVFGALFAKTWRIYRIFT----NKKLKRIVIKDK-QLLKIVGILllIDIIILILWTIVDPLkptrvlvLSEISDDVKY 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 729 GKIVILC-NKGSVVAFHVVLGYLGS-LALGSFtLAFLARNLPDT-FNEAKFLTFSM--LVFCSVwiTFLPVYHSTRGK-- 801
Cdd:cd15047   156 EYVVHCCsSSNGIIWLGILLAYKGLlLLFGCF-LAWKTRNVDIEeFNESKYIGISIynVLFLSV--IGVPLSFVLTDSpd 232
                         250       260
                  ....*....|....*....|....*
gi 1883538153 802 VMVVVEVFSILASSAGLLMCIFVPK 826
Cdd:cd15047   233 TSYLIISAAILFCTTATLCLLFVPK 257
PBP1_mGluR_groupII cd06375
ligand binding domain of the group II metabotropic glutamate receptor; Ligand binding domain ...
78-407 9.98e-10

ligand binding domain of the group II metabotropic glutamate receptor; Ligand binding domain of the group II metabotropic glutamate receptor, a family that contains mGlu2R and mGlu3R, all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes


Pssm-ID: 380598 [Multi-domain]  Cd Length: 462  Bit Score: 61.76  E-value: 9.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  78 LLVMFFATDEINKNPYLLPNMSLMFSII---GGNCHDLLRSLDQEYAQIDgHMNFVNYFCYLDDSCAT---------GLT 145
Cdd:cd06375    37 LEAMLFAIDRINRDPHLLPGVRLGVHILdtcSRDTYALEQSLEFVRASLT-KVDDSEYMCPDDGSYAIqedsplpiaGVI 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 146 GPSWKT-SLKLA-----MHssMPLVFFGPFNPNLRDHDRLPHVHQVAPKDTHLSHGMVSLMFHFRWTWIGLVISDDDQGI 219
Cdd:cd06375   116 GGSYSSvSIQVAnllrlFQ--IPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGE 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 220 QFLSDLREESQRHGICLAFVNMIPENMQiymtrATIYDTQI----MTSSAKVVIIY---GDMNSTLEASFRrweeLGARR 292
Cdd:cd06375   194 TGIEAFEQEARLRNICIATAEKVGRSAD-----RKSFDGVIrellQKPNARVVVLFtrsDDARELLAAAKR----LNASF 264
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 293 IWITTTQWDVITNKKDFTLNLFHGTITFAHHKDEIPKFRNFMQTkktakyLVDISHTILEW------NYFNCSisknssk 366
Cdd:cd06375   265 TWVASDGWGAQESIVKGSEDVAEGAITLELASHPIPDFDRYFQS------LTPYNNHRNPWfrdfweQKFQCS------- 331
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1883538153 367 mghftFNNTLQWTALHNYDMALSDEGYN-------LYNAVYAVAHTYH 407
Cdd:cd06375   332 -----LQNKSQAASVSDKHLSIDSSNYEqeskimfVVNAVYAMAHALH 374
PBP1_mGluR_groupIII cd06376
ligand-binding domain of the group III metabotropic glutamate receptor; Ligand-binding domain ...
81-407 6.47e-09

ligand-binding domain of the group III metabotropic glutamate receptor; Ligand-binding domain of the group III metabotropic glutamate receptor, a family which contains mGlu4R, mGluR6R, mGluR7, and mGluR8; all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes.


Pssm-ID: 380599 [Multi-domain]  Cd Length: 467  Bit Score: 59.05  E-value: 6.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  81 MFFATDEINKNPYLLPNMSLMFSIIGgNCHDLLRSLDQEyaqidghMNFVNYFCYLDDS---CATG----LTGPSWKTSL 153
Cdd:cd06376    40 MLYALDQINSDPDLLPNVTLGARILD-TCSRDTYALEQS-------LTFVQALIQKDTSdvrCTNGdppvFVKPEKVVGV 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 154 KLAMHSS-------------MPLVFFGPFNPNLRDHDRLPHVHQVAPKDTHLSHGMVSLMFHFRWTWIGLVISDDD---Q 217
Cdd:cd06376   112 IGASASSvsimvanilrlfqIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGNygeK 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 218 GIQFLSDLREESQrhGICLAFVNMIPenmqiYMTRATIYDTQIM----TSSAKVVIIYGDMNST---LEASFRrwEELGA 290
Cdd:cd06376   192 GVESFVQISREAG--GVCIAQSEKIP-----RERRTGDFDKIIKrlleTPNARAVVIFADEDDIrrvLAAAKR--ANKTG 262
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 291 RRIWITTTQWDVITNKKDFTLNLFHGTITFAHHKDEIPKFRNFMQTKKTAKYLVDISHTILEWNYFNCSISKNSSKMGHF 370
Cdd:cd06376   263 HFLWVGSDSWGAKISPVLQQEDVAEGAITILPKRASIEGFDAYFTSRTLENNRRNVWFAEFWEENFNCKLTSSGSKKEDT 342
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1883538153 371 TFNNTLQwtalhnyDMALSDEGYN-------LYNAVYAVAHTYH 407
Cdd:cd06376   343 LRKCTGQ-------ERIGRDSGYEqegkvqfVVDAVYAMAHALH 379
7tmC_GPR158-like cd15293
orphan GPR158 and similar proteins, member of the class C family of seven-transmembrane G ...
583-831 6.36e-08

orphan GPR158 and similar proteins, member of the class C family of seven-transmembrane G protein-coupled receptors; This group includes orphan receptors GPR158, GPR158-like (also called GPR179) and similar proteins. These orphan receptors are closely related to the type B receptor for gamma-aminobutyric acid (GABA-B), which is activated by its endogenous ligand GABA, the principal inhibitory neurotransmitter. The functional GABA-B receptor is an obligatory heterodimer composed of two related subunits, GABA-B1, which is primarily involved in GABA ligand binding, and GABA-B2, which is responsible for both G-protein coupling and trafficking of the heterodimer to the plasma membrane. Activation of GABA-B couples to G(i/o)-type G proteins, which in turn modulate three major downstream effectors: adenylate cyclase, voltage-sensitive Ca2+ channels, and inwardly-rectifying K+ channels. Consequently, GABA-B receptor produces slow and sustained inhibitory responses by decreased neurotransmitter release via inhibition of Ca2+ channels and by postsynaptic hyperpolarization via the activation of K+ channels through the G-protein beta-gamma dimer. The GABA-B is expressed in both pre- and postsynaptic sites of glutamatergic and GABAergic neurons in the brain where it regulates synaptic activity. Thus, the GABA-B receptor agonist, baclofen, is used to treat muscle tightness and cramping caused by spasticity in multiple sclerosis patients. Moreover, GABA-B antagonists improves cognitive performance in mammals, while GABA-B agonists suppress cognitive behavior. In most of the class C family members, the extracellular Venus-flytrap domain in the N-terminus is connected to the seven-transmembrane (7TM) via a cysteine-rich domain (CRD). However, in the GABA-B receptor, the CRD is absent in both subunits and the Venus-flytrap ligand-binding domain is directly connected to the 7TM via a 10-15 amino acids linker, suggesting that GABA-B receptor may utilize a different activation mechanism.


Pssm-ID: 320420  Cd Length: 252  Bit Score: 54.53  E-value: 6.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 583 GMALGCMALSFSAITILVLVTFvKYKDTPIVKANNRILSYILLISLVFcfLCSLLFIGH--PDQVTCILQQTTFGVLFTV 660
Cdd:cd15293     4 IAVLAVQAICILLCLVLALVVF-RFRKVKVIKAASPILLELILFGALL--LYFPVFILYfePSVFRCILRPWFRHLGFAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 661 SVSTVLAKTITVVMAFKLttpgRRMRGMMMTGAP--KLVIPICtLIQLVLCGIWLVTSPPFIDRDIQSEHGKI-VILCNk 737
Cdd:cd15293    81 VYGALILKTYRILVVFRS----RSARRVHLTDRDllKRLGLIV-LVVLGYLAAWTAVNPPNVEVGLTLTSSGLkFNVCS- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 738 gSVVAFHVVLGY-LGSLALGSFtLAFLARNLPDTFNEAKFLTFSMLVFCSVWITFLPVYHSTRGK----VMVVVEVFSIL 812
Cdd:cd15293   155 -LDWWDYVMAIAeLLFLLWGVY-LCYAVRKAPSAFNESRYISLAIYNELLLSVIFNIIRFFLLPSlhpdLLFLLFFLHTQ 232
                         250
                  ....*....|....*....
gi 1883538153 813 ASSAGLLMCIFVPKCYVIL 831
Cdd:cd15293   233 LTVTVTLLLIFGPKFYLVL 251
PBP1_ABC_transporter_GPCR_C-like cd04509
Family C of G-protein coupled receptors and their close homologs, the type 1 ...
81-300 1.03e-06

Family C of G-protein coupled receptors and their close homologs, the type 1 periplasmic-binding proteins of ATP-binding cassette transporter-like systems; This CD includes members of the family C of G-protein coupled receptors and their close homologs, the type 1 periplasmic-binding proteins of ATP-binding cassette transporter-like systems. The family C GPCR includes glutamate/glycine-gated ion channels such as the NMDA receptor, G-protein-coupled receptors, metabotropic glutamate, GABA-B, calcium sensing, pheromone receptors, and atrial natriuretic peptide-guanylate cyclase receptors. The glutamate receptors that form cation-selective ion channels, iGluR, can be classified into three different subgroups according to their binding-affinity for the agonists NMDA (N-methyl-D-asparate), AMPA (alpha-amino-3-dihydro-5-methyl-3-oxo-4-isoxazolepropionic acid), and kainate. L-glutamate is a major neurotransmitter in the brain of vertebrates and acts through either mGluRs or iGluRs. mGluRs subunits possess seven transmembrane segments and a large N-terminal extracellular domain. ABC-type leucine-isoleucine-valine binding protein (LIVBP) is a bacterial periplasmic binding protein that has homology with the amino-terminal domain of the glutamate-receptor ion channels (iGluRs). The extracellular regions of iGluRs are made of two PBP-like domains in tandem, a LIVBP-like domain that constitutes the N terminus (included in this model) followed by a domain related to lysine-arginine-ornithine-binding protein (LAOBP) that belongs to the type 2 periplasmic binding fold protein superfamily. The uncharacterized periplasmic components of various ABC-type transport systems are also included in this family.


Pssm-ID: 380490  Cd Length: 306  Bit Score: 51.54  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  81 MFFATDEINKNPYLLPNMSLMFSIIGGNCHDllrsldqEYAqIDGHMNFVN--YFCYLDDSCATGLTGPSWKTSLKLAM- 157
Cdd:cd04509    33 MEQALDDINADPNLLPNNTLGIVIYDDCCDP-------KQA-LEQSNKFVNdlIQKDTSDVRCTNGEPPVFVKPEGIKGv 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 158 --HSS---------------MPLVFFGPFNPNLRDHDRLPHVHQVAPKDTHLSHGMVSLMFHFRWTWIGLVISDDDQGIQ 220
Cdd:cd04509   105 igHLCssvtipvsnilelfgIPQITYAATAPELSDDRGYQLFLRVVPLDSDQAPAMADIVKEKVWQYVSIVHDEGQYGEG 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 221 FLSDLREESQRHGICLAFVNMIPENmqiymtRATI-YDTQIM----TSSAKVVIIYG---DMNSTLEASfRRWEELGaRR 292
Cdd:cd04509   185 GARAFQDGLKKGGLCIAFSDGITAG------EKTKdFDRLVArlkkENNIRFVVYFGyhpEMGQILRAA-RRAGLVG-KF 256

                  ....*...
gi 1883538153 293 IWITTTQW 300
Cdd:cd04509   257 QFMGSDGW 264
PBP1_mGluR_groupI cd06374
ligand binding domain of the group I metabotropic glutamate receptor; Ligand binding domain of ...
80-407 1.79e-05

ligand binding domain of the group I metabotropic glutamate receptor; Ligand binding domain of the group I metabotropic glutamate receptor, a family containing mGlu1R and mGlu5R, all of which stimulate phospholipase C (PLC) hydrolysis. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes.


Pssm-ID: 380597 [Multi-domain]  Cd Length: 474  Bit Score: 48.11  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153  80 VMFFATDEINKNPYLLPNMSLmfsiiGGNCHD--------LLRSLD---QEYAQIDGHMNFVNyfCYLDDSCA------- 141
Cdd:cd06374    46 AMFRTLDKINKDPNLLPNITL-----GIEIRDscwyspvaLEQSIEfirDSVASVEDEKDTQN--TPDPTPLSppenrkp 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 142 -TGLTGPSwKTSLKLAMHS-----SMPLVFFGPFNPNLRDHDRLPHVHQVAPKDTHLSHGMVSLMFHFRWTWIGLVISDD 215
Cdd:cd06374   119 iVGVIGPG-SSSVTIQVQNllqlfHIPQIGYSATSIDLSDKSLYKYFLRVVPSDYLQARAMLDIVKRYNWTYVSTVHTEG 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 216 DQGIQFLSDLREESQRHGICLAFVNMIPENMQIYMTRATIYDTQIMTSSAKVVIIY--GDMNSTLEASFRRweeLGARR- 292
Cdd:cd06374   198 NYGESGIEAFKELAAEEGICIAHSDKIYSNAGEEEFDRLLRKLMNTPNKARVVVCFceGETVRGLLKAMRR---LNATGh 274
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 293 -IWITTTQW----DVITNKKDftlnLFHGTITFAHHKDEIPKFRNFMQTkktakyLVDISHTILEW------NYFNCSIS 361
Cdd:cd06374   275 fLLIGSDGWadrkDVVEGYED----EAAGGITIKIHSPEVESFDEYYFN------LKPETNSRNPWfrefwqHRFDCRLP 344
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1883538153 362 knsskmGHFTFNNTLQWTALHNydmALSDEGYN-------LYNAVYAVAHTYH 407
Cdd:cd06374   345 ------GHPDENPYFKKCCTGE---ESLLGNYVqdsklgfVINAIYAMAHALH 388
PBP1_GABAb_receptor_plant cd19990
periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close ...
162-334 2.50e-05

periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants; This group includes the ligand-binding domain of Arabidopsis thaliana glutamate receptors, which have sequence similarity with animal ionotropic glutamate receptor and its close homologs in other plants. The ligand-binding domain of GABAb receptors are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and, like glutamate and other transmitters, acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb receptor or GABAbR). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha-i proteins, and activation causes a decrease in calcium, an increase in potassium membrane conductance, and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release, for example.


Pssm-ID: 380645 [Multi-domain]  Cd Length: 373  Bit Score: 47.61  E-value: 2.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 162 PLVFFGPFNPNLrDHDRLPHVHQVAPKDTHLSHGMVSLMFHFRWTWIGLVISDDDQG---IQFLSD-LREESQRHGICLA 237
Cdd:cd19990    90 PIISFSATSPTL-SSLRWPFFIRMTHNDSSQMKAIAAIVQSYGWRRVVLIYEDDDYGsgiIPYLSDaLQEVGSRIEYRVA 168
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1883538153 238 FVNMIPENMqiymtratIYD--TQIMTSSAKVVIIYgdMNSTLeAS--FRRWEELGARR---IWITTtqwDVITN----K 306
Cdd:cd19990   169 LPPSSPEDS--------IEEelIKLKSMQSRVFVVH--MSSLL-ASrlFQEAKKLGMMEkgyVWIVT---DGITNlldsL 234
                         170       180
                  ....*....|....*....|....*...
gi 1883538153 307 KDFTLNLFHGTITFAHHKDEIPKFRNFM 334
Cdd:cd19990   235 DSSTISSMQGVIGIKTYIPESSEFQDFK 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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